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Protein

Plastin-2

Gene

Lcp1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Actin-binding protein. Plays a role in the activation of T-cells in response to costimulation through TCR/CD3 and CD2 or CD28. Modulates the cell surface expression of IL2RA/CD25 and CD69.By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Calcium bindingi22 – 331PROSITE-ProRule annotationAdd BLAST12
Calcium bindingi62 – 732PROSITE-ProRule annotationAdd BLAST12

GO - Molecular functioni

  • actin filament binding Source: MGI
  • calcium ion binding Source: InterPro
  • GTPase binding Source: MGI
  • identical protein binding Source: MGI
  • integrin binding Source: MGI

GO - Biological processi

Keywordsi

Molecular functionActin-binding
LigandCalcium, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Plastin-2
Alternative name(s):
65 kDa macrophage protein
L-plastin
Lymphocyte cytosolic protein 1
Short name:
LCP-1
pp65
Gene namesi
Name:Lcp1
Synonyms:Pls2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 14

Organism-specific databases

MGIiMGI:104808 Lcp1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell junction, Cell membrane, Cell projection, Cytoplasm, Cytoskeleton, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00000737442 – 627Plastin-2Add BLAST626

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineBy similarity1
Modified residuei5PhosphoserineCombined sources1 Publication1
Modified residuei7Phosphoserine1 Publication1
Modified residuei28PhosphotyrosineBy similarity1
Modified residuei30PhosphoserineCombined sources1
Modified residuei76N6-acetyllysineBy similarity1
Modified residuei88N6-acetyllysineBy similarity1
Modified residuei124PhosphotyrosineBy similarity1
Modified residuei257PhosphoserineCombined sources1
Modified residuei290PhosphoserineBy similarity1
Modified residuei291PhosphothreonineBy similarity1
Modified residuei294N6-acetyllysineBy similarity1
Modified residuei297N6-acetyllysineBy similarity1
Modified residuei323PhosphoserineBy similarity1
Modified residuei353PhosphothreonineBy similarity1
Modified residuei361N6-acetyllysineBy similarity1
Modified residuei406PhosphoserineBy similarity1
Modified residuei472N6-acetyllysineBy similarity1
Modified residuei474PhosphoserineBy similarity1
Modified residuei542N6-acetyllysineBy similarity1
Modified residuei579N6-acetyllysineBy similarity1

Post-translational modificationi

Phosphorylated on a serine residue in response to costimulation through TCR/CD3 and CD2 or CD28. Serine phosphorylation promotes association with the actin cytoskeleton and targeting to peripheral cell projections (By similarity).By similarity

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiQ61233
MaxQBiQ61233
PaxDbiQ61233
PeptideAtlasiQ61233
PRIDEiQ61233

2D gel databases

COMPLUYEAST-2DPAGEiQ61233
REPRODUCTION-2DPAGEiQ61233

PTM databases

CarbonylDBiQ61233
iPTMnetiQ61233
PhosphoSitePlusiQ61233
SwissPalmiQ61233

Expressioni

Gene expression databases

BgeeiENSMUSG00000021998
CleanExiMM_LCP1
ExpressionAtlasiQ61233 baseline and differential
GenevisibleiQ61233 MM

Interactioni

Subunit structurei

Monomer (By similarity). Interacts with AIF1 (PubMed:14756805). Interacts with actin (By similarity).By similarity1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
Mapk14P478115EBI-309345,EBI-298727

GO - Molecular functioni

  • actin filament binding Source: MGI
  • GTPase binding Source: MGI
  • identical protein binding Source: MGI
  • integrin binding Source: MGI

Protein-protein interaction databases

BioGridi202256, 5 interactors
IntActiQ61233, 7 interactors
MINTiQ61233
STRINGi10090.ENSMUSP00000116271

Structurei

3D structure databases

ProteinModelPortaliQ61233
SMRiQ61233
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini9 – 44EF-hand 1PROSITE-ProRule annotationAdd BLAST36
Domaini49 – 84EF-hand 2PROSITE-ProRule annotationAdd BLAST36
Domaini120 – 236Calponin-homology (CH) 1PROSITE-ProRule annotationAdd BLAST117
Domaini264 – 375Calponin-homology (CH) 2PROSITE-ProRule annotationAdd BLAST112
Domaini394 – 503Calponin-homology (CH) 3PROSITE-ProRule annotationAdd BLAST110
Domaini515 – 624Calponin-homology (CH) 4PROSITE-ProRule annotationAdd BLAST110

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni106 – 379Actin-binding 1Add BLAST274
Regioni380 – 624Actin-binding 2Add BLAST245

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG0046 Eukaryota
COG5069 LUCA
GeneTreeiENSGT00390000005691
HOGENOMiHOG000213447
HOVERGENiHBG003082
InParanoidiQ61233
KOiK17276
OMAiMFDECKD
OrthoDBiEOG091G03YP
PhylomeDBiQ61233
TreeFamiTF300680

Family and domain databases

CDDicd00014 CH, 2 hits
cd00051 EFh, 1 hit
Gene3Di1.10.418.10, 4 hits
InterProiView protein in InterPro
IPR001589 Actinin_actin-bd_CS
IPR001715 CH-domain
IPR036872 CH_dom_sf
IPR011992 EF-hand-dom_pair
IPR018247 EF_Hand_1_Ca_BS
IPR002048 EF_hand_dom
PfamiView protein in Pfam
PF00307 CH, 4 hits
PF13499 EF-hand_7, 1 hit
SMARTiView protein in SMART
SM00033 CH, 4 hits
SM00054 EFh, 2 hits
SUPFAMiSSF47473 SSF47473, 1 hit
SSF47576 SSF47576, 1 hit
PROSITEiView protein in PROSITE
PS00019 ACTININ_1, 2 hits
PS00020 ACTININ_2, 2 hits
PS50021 CH, 4 hits
PS00018 EF_HAND_1, 2 hits
PS50222 EF_HAND_2, 2 hits

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q61233-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MARGSVSDEE MMELREAFAK VDTDGNGYIS CNELNDLFKA ACLPLPGYRV
60 70 80 90 100
REITENLMAT GDLDQDGKIS FDEFIKVFHG LKSTEVAKTF RKAINKKEGI
110 120 130 140 150
CAIGGTSEQS SVGTQHSYSE EEKYAFVNWI NKALENDPDC RHVIPMNPNT
160 170 180 190 200
DDLFNAVGDG IVLCKMINLS VPDTIDERTI NKKKLTPFTI QENLNLALNS
210 220 230 240 250
ASAIGCHVVN IGAEDLKEGK PYLVLGLLWQ VIKIGLFADI ELSRNEALIA
260 270 280 290 300
LLREGESLED LMKLSPEELL LRWANYHLEN AGCTKITNFS TDIKDSKAYY
310 320 330 340 350
HLLEQVAPKG DEEGIPAVVI DMSGLREKDD IQRAECMLQQ AERLGCRQFV
360 370 380 390 400
TATDVVRGNP KLNLAFIANL FNKYPALHKP ENQDIDWGAL EGETREERTF
410 420 430 440 450
RNWMNSLGVN PRVNHLYSDL SDALVIFQLY EKIKVPVDWN RVNKPPYPKL
460 470 480 490 500
GGNMKKLENC NYAVDLGKNQ AKFSLVGIAG QDLNEGNRTL TLALVWQLMR
510 520 530 540 550
RYTLNILEDI GGGQKVNDDI IVNWVNTTLK EAQKSSSIAS FKDPKISTSL
560 570 580 590 600
PVLDLIDAIQ PGSINYDLLK TENLDDEEKL NNAKYAISMA RKIGARVYAL
610 620
PEDLVEVNPK MVMTVFACLM GKGMKRV
Length:627
Mass (Da):70,149
Last modified:January 23, 2007 - v4
Checksum:iF0A1E6CA1C11A8E6
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti26N → K in BAC27208 (PubMed:16141072).Curated1
Sequence conflicti83S → T in BAA07085 (PubMed:7897227).Curated1
Sequence conflicti292D → H in BAA07085 (PubMed:7897227).Curated1
Sequence conflicti367 – 369IAN → ANL in BAA07085 (PubMed:7897227).Curated3
Sequence conflicti479A → G in BAA07085 (PubMed:7897227).Curated1
Sequence conflicti527T → M in BAA07085 (PubMed:7897227).Curated1
Sequence conflicti558A → S in BAB26141 (PubMed:16141072).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D37837 mRNA Translation: BAA07085.1
AK009211 mRNA Translation: BAB26141.1
AK030806 mRNA Translation: BAE20456.1
AK030987 mRNA Translation: BAC27205.1
AK030996 mRNA Translation: BAC27208.1
AK088202 mRNA Translation: BAC40207.1
AK149790 mRNA Translation: BAE29087.1
AK151155 mRNA Translation: BAE30161.1
AK152891 mRNA Translation: BAE31574.1
AK153082 mRNA Translation: BAE31707.1
AK153206 mRNA Translation: BAE31806.1
AK169728 mRNA Translation: BAE41332.1
AK169833 mRNA Translation: BAE41398.1
BC022943 mRNA Translation: AAH22943.1
CCDSiCCDS27276.1
PIRiI49445
RefSeqiNP_001234913.1, NM_001247984.1
NP_032905.2, NM_008879.4
XP_006518762.1, XM_006518699.1
XP_006518764.1, XM_006518701.3
XP_006518765.1, XM_006518702.3
XP_006518766.1, XM_006518703.3
XP_006518767.1, XM_006518704.1
XP_017171409.1, XM_017315920.1
UniGeneiMm.153911
Mm.484415

Genome annotation databases

EnsembliENSMUST00000124499; ENSMUSP00000121201; ENSMUSG00000021998
ENSMUST00000131802; ENSMUSP00000117137; ENSMUSG00000021998
ENSMUST00000145303; ENSMUSP00000116271; ENSMUSG00000021998
GeneIDi18826
KEGGimmu:18826
UCSCiuc007uqm.2 mouse

Similar proteinsi

Entry informationi

Entry nameiPLSL_MOUSE
AccessioniPrimary (citable) accession number: Q61233
Secondary accession number(s): Q3UE24, Q8R1X3, Q9CV77
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: January 23, 2007
Last modified: March 28, 2018
This is version 176 of the entry and version 4 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

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