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Q61224

- 5HT1D_MOUSE

UniProt

Q61224 - 5HT1D_MOUSE

Protein

5-hydroxytryptamine receptor 1D

Gene

Htr1d

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 114 (01 Oct 2014)
      Sequence version 2 (27 Jul 2011)
      Previous versions | rss
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    Functioni

    G-protein coupled receptor for 5-hydroxytryptamine (serotonin). Also functions as a receptor for various alkaloids and psychoactive substances. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling inhibits adenylate cyclase activity. Regulates the release of 5-hydroxytryptamine in the brain, and thereby affects neural activity. May also play a role in regulating the release of other neurotransmitters. May play a role in vasoconstriction.

    GO - Molecular functioni

    1. serotonin binding Source: MGI
    2. serotonin receptor activity Source: MGI

    GO - Biological processi

    1. adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway Source: UniProtKB
    2. intestine smooth muscle contraction Source: Ensembl
    3. regulation of behavior Source: InterPro
    4. regulation of locomotion Source: InterPro
    5. response to toxic substance Source: MGI
    6. serotonin receptor signaling pathway Source: GOC
    7. synaptic transmission Source: InterPro
    8. vasoconstriction Source: InterPro

    Keywords - Molecular functioni

    G-protein coupled receptor, Receptor, Transducer

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    5-hydroxytryptamine receptor 1D
    Short name:
    5-HT-1D
    Short name:
    5-HT1D
    Alternative name(s):
    Serotonin receptor 1D
    Gene namesi
    Name:Htr1d
    Synonyms:Gpcr14
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 4

    Organism-specific databases

    MGIiMGI:96276. Htr1d.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of plasma membrane Source: UniProtKB

    Keywords - Cellular componenti

    Cell membrane, Membrane

    Pathology & Biotechi

    Disruption phenotypei

    No visible phenotype. Depending on the task, mutant mice show improved motor coordination, especially in avoiding hind limb slips when crossing a narrow beam and in climbing onto a horizontal hanging wire.1 Publication

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 3743745-hydroxytryptamine receptor 1DPRO_0000068928Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi5 – 51N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi17 – 171N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi21 – 211N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi108 ↔ 185PROSITE-ProRule annotation

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    PRIDEiQ61224.

    PTM databases

    PhosphoSiteiQ61224.

    Expressioni

    Tissue specificityi

    Detected in the motor column in spinal cord, and in several cranial motor nuclei, including nucleus ambiguous, oculomotoris, trochelaris and abducens. Detected in gamma motor neurons in the lumbar spinal cord. Detected in proprioceptive sensory neurons in dorsal root ganglia.1 Publication

    Gene expression databases

    BgeeiQ61224.
    CleanExiMM_HTR1D.
    GenevestigatoriQ61224.

    Interactioni

    Subunit structurei

    Homodimer. Heterodimer with HTR1B By similarity.By similarity

    Protein-protein interaction databases

    STRINGi10090.ENSMUSP00000112840.

    Structurei

    3D structure databases

    ProteinModelPortaliQ61224.
    SMRiQ61224. Positions 35-371.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 3535ExtracellularBy similarityAdd
    BLAST
    Topological domaini62 – 7211CytoplasmicBy similarityAdd
    BLAST
    Topological domaini96 – 10914ExtracellularBy similarityAdd
    BLAST
    Topological domaini132 – 15120CytoplasmicBy similarityAdd
    BLAST
    Topological domaini174 – 19118ExtracellularBy similarityAdd
    BLAST
    Topological domaini215 – 29985CytoplasmicBy similarityAdd
    BLAST
    Topological domaini324 – 3329ExtracellularBy similarity
    Topological domaini358 – 37417CytoplasmicBy similarityAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei36 – 6126Helical; Name=1By similarityAdd
    BLAST
    Transmembranei73 – 9523Helical; Name=2By similarityAdd
    BLAST
    Transmembranei110 – 13122Helical; Name=3By similarityAdd
    BLAST
    Transmembranei152 – 17322Helical; Name=4By similarityAdd
    BLAST
    Transmembranei192 – 21423Helical; Name=5By similarityAdd
    BLAST
    Transmembranei300 – 32324Helical; Name=6By similarityAdd
    BLAST
    Transmembranei333 – 35725Helical; Name=7By similarityAdd
    BLAST

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni111 – 12010Agonist bindingBy similarity
    Regioni311 – 3155Agonist bindingBy similarity

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi132 – 1343DRY motif; important for ligand-induced conformation changesBy similarity
    Motifi349 – 3535NPxxY motif; important for ligand-induced conformation changes and signalingBy similarity

    Sequence similaritiesi

    Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG249628.
    GeneTreeiENSGT00750000117301.
    HOGENOMiHOG000239242.
    HOVERGENiHBG106962.
    InParanoidiQ8BUW7.
    KOiK04153.
    OMAiCRDSCWI.
    OrthoDBiEOG7NCV3Q.
    TreeFamiTF316350.

    Family and domain databases

    Gene3Di1.20.1070.10. 2 hits.
    InterProiIPR000505. 5HT1D_rcpt.
    IPR002231. 5HT_rcpt.
    IPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    [Graphical view]
    PANTHERiPTHR24247:SF17. PTHR24247:SF17. 1 hit.
    PfamiPF00001. 7tm_1. 1 hit.
    [Graphical view]
    PRINTSiPR00514. 5HT1DRECEPTR.
    PR01101. 5HTRECEPTOR.
    PR00237. GPCRRHODOPSN.
    PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
    PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q61224-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSPPNQSLEG LPQEASNRSL NVTGAWDPEV LQALRISLVV VLSVITLATV    50
    LSNAFVLTTI LLTKKLHTPA NYLIGSLATT DLLVSILVMP ISIAYTTTRT 100
    WNFGQILCDI WVSSDITCCT ASILHLCVIA LDRYWAITDA LEYSKRRTAG 150
    HAAAMIAAVW IISICISIPP LFWRQATAHE EMSDCLVNTS QISYTIYSTC 200
    GAFYIPSILL IILYGRIYVA ARSRILNPPS LYGKRFTTAQ LITGSAGSSL 250
    CSLNPSLHES HTHTVGSPLF FNQVKIKLAD SILERKRISA ARERKATKTL 300
    GIILGAFIIC WLPFFVVSLV LPICRDSCWI HPALFDFFTW LGYLNSLINP 350
    VIYTVFNEDF RQAFQKVVHF RKIS 374
    Length:374
    Mass (Da):41,594
    Last modified:July 27, 2011 - v2
    Checksum:i2FE947DF7DBEF14D
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti3 – 31P → L in CAA64395. (PubMed:8978753)Curated
    Sequence conflicti22 – 221V → A in CAA64395. (PubMed:8978753)Curated
    Sequence conflicti22 – 221V → A in EDL29938. 1 PublicationCurated
    Sequence conflicti22 – 221V → A in EDL29939. 1 PublicationCurated
    Sequence conflicti22 – 221V → A in AAI03533. (PubMed:15489334)Curated
    Sequence conflicti22 – 221V → A in AAI03536. (PubMed:15489334)Curated
    Sequence conflicti22 – 221V → A in AAI03537. (PubMed:15489334)Curated
    Sequence conflicti373 – 3731I → A in CAA64395. (PubMed:8978753)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X94908 Genomic DNA. Translation: CAA64395.1.
    AK082016 mRNA. Translation: BAC38393.1.
    AL670673 Genomic DNA. Translation: CAM21107.1.
    CH466552 Genomic DNA. Translation: EDL29938.1.
    CH466552 Genomic DNA. Translation: EDL29939.1.
    BC103532 mRNA. Translation: AAI03533.1.
    BC103535 mRNA. Translation: AAI03536.1.
    BC103536 mRNA. Translation: AAI03537.1.
    L20335 mRNA. Translation: AAA16847.1.
    CCDSiCCDS18806.1.
    PIRiF48909.
    RefSeqiNP_001272411.1. NM_001285482.1.
    NP_001272412.1. NM_001285483.1.
    NP_001272413.1. NM_001285484.1.
    NP_032335.2. NM_008309.5.
    XP_006538639.1. XM_006538576.1.
    XP_006538640.1. XM_006538577.1.
    XP_006538641.1. XM_006538578.1.
    UniGeneiMm.40573.

    Genome annotation databases

    EnsembliENSMUST00000088677; ENSMUSP00000086052; ENSMUSG00000070687.
    ENSMUST00000117699; ENSMUSP00000112840; ENSMUSG00000070687.
    ENSMUST00000121571; ENSMUSP00000112402; ENSMUSG00000070687.
    GeneIDi15552.
    KEGGimmu:15552.
    UCSCiuc008vic.2. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X94908 Genomic DNA. Translation: CAA64395.1 .
    AK082016 mRNA. Translation: BAC38393.1 .
    AL670673 Genomic DNA. Translation: CAM21107.1 .
    CH466552 Genomic DNA. Translation: EDL29938.1 .
    CH466552 Genomic DNA. Translation: EDL29939.1 .
    BC103532 mRNA. Translation: AAI03533.1 .
    BC103535 mRNA. Translation: AAI03536.1 .
    BC103536 mRNA. Translation: AAI03537.1 .
    L20335 mRNA. Translation: AAA16847.1 .
    CCDSi CCDS18806.1.
    PIRi F48909.
    RefSeqi NP_001272411.1. NM_001285482.1.
    NP_001272412.1. NM_001285483.1.
    NP_001272413.1. NM_001285484.1.
    NP_032335.2. NM_008309.5.
    XP_006538639.1. XM_006538576.1.
    XP_006538640.1. XM_006538577.1.
    XP_006538641.1. XM_006538578.1.
    UniGenei Mm.40573.

    3D structure databases

    ProteinModelPortali Q61224.
    SMRi Q61224. Positions 35-371.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 10090.ENSMUSP00000112840.

    Chemistry

    BindingDBi Q61224.
    ChEMBLi CHEMBL4297.
    GuidetoPHARMACOLOGYi 3.

    Protein family/group databases

    GPCRDBi Search...

    PTM databases

    PhosphoSitei Q61224.

    Proteomic databases

    PRIDEi Q61224.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000088677 ; ENSMUSP00000086052 ; ENSMUSG00000070687 .
    ENSMUST00000117699 ; ENSMUSP00000112840 ; ENSMUSG00000070687 .
    ENSMUST00000121571 ; ENSMUSP00000112402 ; ENSMUSG00000070687 .
    GeneIDi 15552.
    KEGGi mmu:15552.
    UCSCi uc008vic.2. mouse.

    Organism-specific databases

    CTDi 3352.
    MGIi MGI:96276. Htr1d.

    Phylogenomic databases

    eggNOGi NOG249628.
    GeneTreei ENSGT00750000117301.
    HOGENOMi HOG000239242.
    HOVERGENi HBG106962.
    InParanoidi Q8BUW7.
    KOi K04153.
    OMAi CRDSCWI.
    OrthoDBi EOG7NCV3Q.
    TreeFami TF316350.

    Miscellaneous databases

    NextBioi 288488.
    PROi Q61224.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q61224.
    CleanExi MM_HTR1D.
    Genevestigatori Q61224.

    Family and domain databases

    Gene3Di 1.20.1070.10. 2 hits.
    InterProi IPR000505. 5HT1D_rcpt.
    IPR002231. 5HT_rcpt.
    IPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    [Graphical view ]
    PANTHERi PTHR24247:SF17. PTHR24247:SF17. 1 hit.
    Pfami PF00001. 7tm_1. 1 hit.
    [Graphical view ]
    PRINTSi PR00514. 5HT1DRECEPTR.
    PR01101. 5HTRECEPTOR.
    PR00237. GPCRRHODOPSN.
    PROSITEi PS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
    PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Sequence and functional analysis of cloned guinea pig and rat serotonin 5-HT1D receptors: common pharmacological features within the 5-HT1D receptor subfamily."
      Wurch T., Palmier C., Colpaert F.C., Pauwels P.J.
      J. Neurochem. 68:410-418(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: NMRI.
      Tissue: Brain.
    2. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6J.
      Tissue: Head.
    3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: C57BL/6J.
    4. Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
      Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    6. "Identification, chromosomal location, and genome organization of mammalian G-protein-coupled receptors."
      Wilkie T.M., Chen Y., Gilbert D.J., Moore K.J., Yu L., Simon M.I., Copeland N.G., Jenkins N.A.
      Genomics 18:175-184(1993) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 135-306.
      Tissue: Testis.
    7. "Sensorimotor function is modulated by the serotonin receptor 1d, a novel marker for gamma motor neurons."
      Enjin A., Leao K.E., Mikulovic S., Le Merre P., Tourtellotte W.G., Kullander K.
      Mol. Cell. Neurosci. 49:322-332(2012) [PubMed] [Europe PMC] [Abstract]
      Cited for: DISRUPTION PHENOTYPE, TISSUE SPECIFICITY.

    Entry informationi

    Entry namei5HT1D_MOUSE
    AccessioniPrimary (citable) accession number: Q61224
    Secondary accession number(s): Q3ZB48, Q61615, Q8BUW7
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1997
    Last sequence update: July 27, 2011
    Last modified: October 1, 2014
    This is version 114 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. 7-transmembrane G-linked receptors
      List of 7-transmembrane G-linked receptor entries
    2. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3