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Q61224

- 5HT1D_MOUSE

UniProt

Q61224 - 5HT1D_MOUSE

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Protein

5-hydroxytryptamine receptor 1D

Gene
Htr1d, Gpcr14
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at transcript leveli

Functioni

G-protein coupled receptor for 5-hydroxytryptamine (serotonin). Also functions as a receptor for various alkaloids and psychoactive substances. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling inhibits adenylate cyclase activity. Regulates the release of 5-hydroxytryptamine in the brain, and thereby affects neural activity. May also play a role in regulating the release of other neurotransmitters. May play a role in vasoconstriction.

GO - Molecular functioni

  1. serotonin binding Source: MGI
  2. serotonin receptor activity Source: MGI

GO - Biological processi

  1. adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway Source: UniProtKB
  2. intestine smooth muscle contraction Source: Ensembl
  3. regulation of behavior Source: InterPro
  4. regulation of locomotion Source: InterPro
  5. response to toxic substance Source: MGI
  6. serotonin receptor signaling pathway Source: GOC
  7. synaptic transmission Source: InterPro
  8. vasoconstriction Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Names & Taxonomyi

Protein namesi
Recommended name:
5-hydroxytryptamine receptor 1D
Short name:
5-HT-1D
Short name:
5-HT1D
Alternative name(s):
Serotonin receptor 1D
Gene namesi
Name:Htr1d
Synonyms:Gpcr14
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 4

Organism-specific databases

MGIiMGI:96276. Htr1d.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 3535Extracellular By similarityAdd
BLAST
Transmembranei36 – 6126Helical; Name=1; By similarityAdd
BLAST
Topological domaini62 – 7211Cytoplasmic By similarityAdd
BLAST
Transmembranei73 – 9523Helical; Name=2; By similarityAdd
BLAST
Topological domaini96 – 10914Extracellular By similarityAdd
BLAST
Transmembranei110 – 13122Helical; Name=3; By similarityAdd
BLAST
Topological domaini132 – 15120Cytoplasmic By similarityAdd
BLAST
Transmembranei152 – 17322Helical; Name=4; By similarityAdd
BLAST
Topological domaini174 – 19118Extracellular By similarityAdd
BLAST
Transmembranei192 – 21423Helical; Name=5; By similarityAdd
BLAST
Topological domaini215 – 29985Cytoplasmic By similarityAdd
BLAST
Transmembranei300 – 32324Helical; Name=6; By similarityAdd
BLAST
Topological domaini324 – 3329Extracellular By similarity
Transmembranei333 – 35725Helical; Name=7; By similarityAdd
BLAST
Topological domaini358 – 37417Cytoplasmic By similarityAdd
BLAST

GO - Cellular componenti

  1. integral component of plasma membrane Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Disruption phenotypei

No visible phenotype. Depending on the task, mutant mice show improved motor coordination, especially in avoiding hind limb slips when crossing a narrow beam and in climbing onto a horizontal hanging wire.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 3743745-hydroxytryptamine receptor 1DPRO_0000068928Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi5 – 51N-linked (GlcNAc...) Reviewed prediction
Glycosylationi17 – 171N-linked (GlcNAc...) Reviewed prediction
Glycosylationi21 – 211N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi108 ↔ 185 By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PRIDEiQ61224.

PTM databases

PhosphoSiteiQ61224.

Expressioni

Tissue specificityi

Detected in the motor column in spinal cord, and in several cranial motor nuclei, including nucleus ambiguous, oculomotoris, trochelaris and abducens. Detected in gamma motor neurons in the lumbar spinal cord. Detected in proprioceptive sensory neurons in dorsal root ganglia.1 Publication

Gene expression databases

BgeeiQ61224.
CleanExiMM_HTR1D.
GenevestigatoriQ61224.

Interactioni

Subunit structurei

Homodimer. Heterodimer with HTR1B By similarity.

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000112840.

Structurei

3D structure databases

ProteinModelPortaliQ61224.
SMRiQ61224. Positions 35-371.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni111 – 12010Agonist binding By similarity
Regioni311 – 3155Agonist binding By similarity

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi132 – 1343DRY motif; important for ligand-induced conformation changes By similarity
Motifi349 – 3535NPxxY motif; important for ligand-induced conformation changes and signaling By similarity

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG249628.
GeneTreeiENSGT00750000117301.
HOGENOMiHOG000239242.
HOVERGENiHBG106962.
InParanoidiQ8BUW7.
KOiK04153.
OMAiCRDSCWI.
OrthoDBiEOG7NCV3Q.
TreeFamiTF316350.

Family and domain databases

Gene3Di1.20.1070.10. 2 hits.
InterProiIPR000505. 5HT1D_rcpt.
IPR002231. 5HT_rcpt.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PANTHERiPTHR24247:SF17. PTHR24247:SF17. 1 hit.
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00514. 5HT1DRECEPTR.
PR01101. 5HTRECEPTOR.
PR00237. GPCRRHODOPSN.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q61224-1 [UniParc]FASTAAdd to Basket

« Hide

MSPPNQSLEG LPQEASNRSL NVTGAWDPEV LQALRISLVV VLSVITLATV    50
LSNAFVLTTI LLTKKLHTPA NYLIGSLATT DLLVSILVMP ISIAYTTTRT 100
WNFGQILCDI WVSSDITCCT ASILHLCVIA LDRYWAITDA LEYSKRRTAG 150
HAAAMIAAVW IISICISIPP LFWRQATAHE EMSDCLVNTS QISYTIYSTC 200
GAFYIPSILL IILYGRIYVA ARSRILNPPS LYGKRFTTAQ LITGSAGSSL 250
CSLNPSLHES HTHTVGSPLF FNQVKIKLAD SILERKRISA ARERKATKTL 300
GIILGAFIIC WLPFFVVSLV LPICRDSCWI HPALFDFFTW LGYLNSLINP 350
VIYTVFNEDF RQAFQKVVHF RKIS 374
Length:374
Mass (Da):41,594
Last modified:July 27, 2011 - v2
Checksum:i2FE947DF7DBEF14D
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti3 – 31P → L in CAA64395. 1 Publication
Sequence conflicti22 – 221V → A in CAA64395. 1 Publication
Sequence conflicti22 – 221V → A in EDL29938. 1 Publication
Sequence conflicti22 – 221V → A in EDL29939. 1 Publication
Sequence conflicti22 – 221V → A in AAI03533. 1 Publication
Sequence conflicti22 – 221V → A in AAI03536. 1 Publication
Sequence conflicti22 – 221V → A in AAI03537. 1 Publication
Sequence conflicti373 – 3731I → A in CAA64395. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X94908 Genomic DNA. Translation: CAA64395.1.
AK082016 mRNA. Translation: BAC38393.1.
AL670673 Genomic DNA. Translation: CAM21107.1.
CH466552 Genomic DNA. Translation: EDL29938.1.
CH466552 Genomic DNA. Translation: EDL29939.1.
BC103532 mRNA. Translation: AAI03533.1.
BC103535 mRNA. Translation: AAI03536.1.
BC103536 mRNA. Translation: AAI03537.1.
L20335 mRNA. Translation: AAA16847.1.
CCDSiCCDS18806.1.
PIRiF48909.
RefSeqiNP_001272411.1. NM_001285482.1.
NP_001272412.1. NM_001285483.1.
NP_001272413.1. NM_001285484.1.
NP_032335.2. NM_008309.5.
XP_006538639.1. XM_006538576.1.
XP_006538640.1. XM_006538577.1.
XP_006538641.1. XM_006538578.1.
UniGeneiMm.40573.

Genome annotation databases

EnsembliENSMUST00000088677; ENSMUSP00000086052; ENSMUSG00000070687.
ENSMUST00000117699; ENSMUSP00000112840; ENSMUSG00000070687.
ENSMUST00000121571; ENSMUSP00000112402; ENSMUSG00000070687.
GeneIDi15552.
KEGGimmu:15552.
UCSCiuc008vic.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X94908 Genomic DNA. Translation: CAA64395.1 .
AK082016 mRNA. Translation: BAC38393.1 .
AL670673 Genomic DNA. Translation: CAM21107.1 .
CH466552 Genomic DNA. Translation: EDL29938.1 .
CH466552 Genomic DNA. Translation: EDL29939.1 .
BC103532 mRNA. Translation: AAI03533.1 .
BC103535 mRNA. Translation: AAI03536.1 .
BC103536 mRNA. Translation: AAI03537.1 .
L20335 mRNA. Translation: AAA16847.1 .
CCDSi CCDS18806.1.
PIRi F48909.
RefSeqi NP_001272411.1. NM_001285482.1.
NP_001272412.1. NM_001285483.1.
NP_001272413.1. NM_001285484.1.
NP_032335.2. NM_008309.5.
XP_006538639.1. XM_006538576.1.
XP_006538640.1. XM_006538577.1.
XP_006538641.1. XM_006538578.1.
UniGenei Mm.40573.

3D structure databases

ProteinModelPortali Q61224.
SMRi Q61224. Positions 35-371.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 10090.ENSMUSP00000112840.

Chemistry

BindingDBi Q61224.
ChEMBLi CHEMBL4297.
GuidetoPHARMACOLOGYi 3.

Protein family/group databases

GPCRDBi Search...

PTM databases

PhosphoSitei Q61224.

Proteomic databases

PRIDEi Q61224.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000088677 ; ENSMUSP00000086052 ; ENSMUSG00000070687 .
ENSMUST00000117699 ; ENSMUSP00000112840 ; ENSMUSG00000070687 .
ENSMUST00000121571 ; ENSMUSP00000112402 ; ENSMUSG00000070687 .
GeneIDi 15552.
KEGGi mmu:15552.
UCSCi uc008vic.2. mouse.

Organism-specific databases

CTDi 3352.
MGIi MGI:96276. Htr1d.

Phylogenomic databases

eggNOGi NOG249628.
GeneTreei ENSGT00750000117301.
HOGENOMi HOG000239242.
HOVERGENi HBG106962.
InParanoidi Q8BUW7.
KOi K04153.
OMAi CRDSCWI.
OrthoDBi EOG7NCV3Q.
TreeFami TF316350.

Miscellaneous databases

NextBioi 288488.
PROi Q61224.
SOURCEi Search...

Gene expression databases

Bgeei Q61224.
CleanExi MM_HTR1D.
Genevestigatori Q61224.

Family and domain databases

Gene3Di 1.20.1070.10. 2 hits.
InterProi IPR000505. 5HT1D_rcpt.
IPR002231. 5HT_rcpt.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view ]
PANTHERi PTHR24247:SF17. PTHR24247:SF17. 1 hit.
Pfami PF00001. 7tm_1. 1 hit.
[Graphical view ]
PRINTSi PR00514. 5HT1DRECEPTR.
PR01101. 5HTRECEPTOR.
PR00237. GPCRRHODOPSN.
PROSITEi PS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Sequence and functional analysis of cloned guinea pig and rat serotonin 5-HT1D receptors: common pharmacological features within the 5-HT1D receptor subfamily."
    Wurch T., Palmier C., Colpaert F.C., Pauwels P.J.
    J. Neurochem. 68:410-418(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: NMRI.
    Tissue: Brain.
  2. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Head.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  4. Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
    Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  6. "Identification, chromosomal location, and genome organization of mammalian G-protein-coupled receptors."
    Wilkie T.M., Chen Y., Gilbert D.J., Moore K.J., Yu L., Simon M.I., Copeland N.G., Jenkins N.A.
    Genomics 18:175-184(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 135-306.
    Tissue: Testis.
  7. "Sensorimotor function is modulated by the serotonin receptor 1d, a novel marker for gamma motor neurons."
    Enjin A., Leao K.E., Mikulovic S., Le Merre P., Tourtellotte W.G., Kullander K.
    Mol. Cell. Neurosci. 49:322-332(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: DISRUPTION PHENOTYPE, TISSUE SPECIFICITY.

Entry informationi

Entry namei5HT1D_MOUSE
AccessioniPrimary (citable) accession number: Q61224
Secondary accession number(s): Q3ZB48, Q61615, Q8BUW7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: July 27, 2011
Last modified: July 9, 2014
This is version 113 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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