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Q61220 (NELL2_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified May 1, 2013. Version 108. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Protein kinase C-binding protein NELL2
Alternative name(s):
MEL91 protein
NEL-like protein 2
Gene names
Name:Nell2
Synonyms:Mel91
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length816 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Subcellular location

Secreted By similarity.

Sequence similarities

Contains 6 EGF-like domains.

Contains 1 laminin G-like domain.

Contains 2 VWFC domains.

Sequence caution

The sequence AAB02924.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.

Ontologies

Keywords
   Cellular componentSecreted
   DomainEGF-like domain
Repeat
Signal
   LigandCalcium
   PTMDisulfide bond
Glycoprotein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Cellular_componentextracellular region

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functioncalcium ion binding

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2121 Potential
Chain22 – 816795Protein kinase C-binding protein NELL2
PRO_0000007667

Regions

Domain64 – 228165Laminin G-like
Domain272 – 33160VWFC 1
Domain397 – 43943EGF-like 1
Domain440 – 48142EGF-like 2; calcium-binding Potential
Domain482 – 52241EGF-like 3; calcium-binding Potential
Domain523 – 55331EGF-like 4
Domain555 – 60147EGF-like 5; calcium-binding Potential
Domain602 – 63736EGF-like 6; calcium-binding Potential
Domain698 – 75659VWFC 2

Amino acid modifications

Glycosylation531N-linked (GlcNAc...) Potential
Glycosylation2251N-linked (GlcNAc...) Potential
Glycosylation2931N-linked (GlcNAc...) Potential
Glycosylation2981N-linked (GlcNAc...) Potential
Glycosylation5171N-linked (GlcNAc...) Potential
Glycosylation6151N-linked (GlcNAc...) Potential
Glycosylation6351N-linked (GlcNAc...) Potential
Disulfide bond401 ↔ 413 By similarity
Disulfide bond407 ↔ 422 By similarity
Disulfide bond424 ↔ 438 By similarity
Disulfide bond444 ↔ 457 By similarity
Disulfide bond451 ↔ 466 By similarity
Disulfide bond468 ↔ 480 By similarity
Disulfide bond486 ↔ 499 By similarity
Disulfide bond493 ↔ 508 By similarity
Disulfide bond510 ↔ 521 By similarity
Disulfide bond525 ↔ 535 By similarity
Disulfide bond529 ↔ 541 By similarity
Disulfide bond543 ↔ 552 By similarity
Disulfide bond559 ↔ 572 By similarity
Disulfide bond566 ↔ 581 By similarity
Disulfide bond583 ↔ 600 By similarity
Disulfide bond606 ↔ 619 By similarity
Disulfide bond613 ↔ 628 By similarity
Disulfide bond630 ↔ 636 By similarity

Sequences

Sequence LengthMass (Da)Tools
Q61220 [UniParc].

Last modified November 1, 1997. Version 2.
Checksum: 5BDD0A946F87E74D

FASTA81691,164
        10         20         30         40         50         60 
MESRVLLRTF CVILGLGAVW GLGVDPSLQI DVLTELELGE STDGVRQVPG LHNGTKAFLF 

        70         80         90        100        110        120 
QESPRSIKAS TATAERFLQK LRNKHEFTIL VTLKQIHLNS GVILSIHHLD HRYLELESSG 

       130        140        150        160        170        180 
HRNEIRLHYR SGTHRPHTEV FPYILADAKW HKLSLAFSAS HLILHIDCNK IYERVVEMPF 

       190        200        210        220        230        240 
TDLALGTTFW LGQRNNAHGY FKGIMQDVHV LVMPQGFIAQ CPDLNRTCPT CNDFHGLVQK 

       250        260        270        280        290        300 
IMELQDILSK TSAKLSRAEQ RMNRLDQCYC ERTCTVKGTT YRESESWTDG CKNCTCLNGT 

       310        320        330        340        350        360 
IQCETLVCPA PDCPPKSAPA YVDGKCCKEC KSTCQFQGRS YFEGERNTAY SSSGMCVLYE 

       370        380        390        400        410        420 
CKDQTMKLVE NIGCPPLDCP ESHQIALSHS CCKVCKGYDF CSEKHTCMEN SVCRNLNDRV 

       430        440        450        460        470        480 
VCSCRDGFRA LREDNAYCED IDECAEGRHY CRENTMCVNT PGSFMCVCKT GYIRIDDYSC 

       490        500        510        520        530        540 
TEHDECLTTQ HNCDENALCF NTVGGHNCVC KPGYTGNGTT CKAFCKDGCR NGGACIAANV 

       550        560        570        580        590        600 
CACPQGFTGP SCETDIDECS EGFVQCDSRA NCINLPGWYH CECRDGYHDN GMFAPGGESC 

       610        620        630        640        650        660 
EDIDECGTGR HSCTNDTICF NLDGGYDCRC PHGKNCTGDC VHEGKVKHTG QIWVLENDRC 

       670        680        690        700        710        720 
SVCSWQTGFV MCRRMVCDCE NPTDDLSCCP ECDPRLSSQC LHQNGETVYN SGDTWVQDCR 

       730        740        750        760        770        780 
QCRCLQGEVD CWPLACPEVE CEFSVLPENE CCPRCVTDPC QADTIRNDIT KTCLDEMNVV 

       790        800        810 
RFTGSSWIKH GTECTLCQCK NGHLCCSVDP QCLQEL

« Hide

References

[1]Elkins D.A., Rossi J.
Submitted (MAY-1996) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		U59230 mRNA. Translation: AAB02924.1. Different initiation.
IPIIPI00224524.
UniGeneMm.3959.

3D structure databases

ProteinModelPortalQ61220.
SMRQ61220. Positions 23-48, 374-636.
ModBaseSearch...

Proteomic databases

PaxDbQ61220.
PRIDEQ61220.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Organism-specific databases

MGIMGI:1858510. Nell2.

Phylogenomic databases

eggNOGNOG253557.
HOVERGENHBG004805.

Gene expression databases

CleanExMM_NELL2.
GenevestigatorQ61220.
GermOnlineENSMUSG00000022454. Mus musculus.

Family and domain databases

Gene3D2.60.120.200. 1 hit.
InterProIPR026823. cEGF.
IPR008985. ConA-like_lec_gl_sf.
IPR013320. ConA-like_subgrp.
IPR000742. EG-like_dom.
IPR001881. EGF-like_Ca-bd.
IPR013032. EGF-like_CS.
IPR000152. EGF-type_Asp/Asn_hydroxyl_site.
IPR018097. EGF_Ca-bd_CS.
IPR001791. Laminin_G.
IPR001007. VWF_C.
[Graphical view]
PfamPF12662. cEGF. 1 hit.
PF07645. EGF_CA. 2 hits.
PF02210. Laminin_G_2. 1 hit.
PF00093. VWC. 2 hits.
[Graphical view]
SMARTSM00181. EGF. 2 hits.
SM00179. EGF_CA. 3 hits.
SM00282. LamG. 1 hit.
SM00210. TSPN. 1 hit.
SM00214. VWC. 2 hits.
[Graphical view]
SUPFAMSSF49899. ConA_like_lec_gl. 1 hit.
PROSITEPS00010. ASX_HYDROXYL. 3 hits.
PS00022. EGF_1. 1 hit.
PS01186. EGF_2. 3 hits.
PS50026. EGF_3. 6 hits.
PS01187. EGF_CA. 3 hits.
PS50025. LAM_G_DOMAIN. False negative.
PS01208. VWFC_1. 2 hits.
PS50184. VWFC_2. 2 hits.
[Graphical view]
ProtoNetSearch...

Other

SOURCESearch...

Entry information

Entry nameNELL2_MOUSE
AccessionPrimary (citable) accession number: Q61220
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1997
Last modified: May 1, 2013
This is version 108 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

SIMILARITY comments

Index of protein domains and families

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