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Q61220 (NELL2_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified March 19, 2014. Version 116. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Protein kinase C-binding protein NELL2
Alternative name(s):
MEL91 protein
NEL-like protein 2
Gene names
Name:Nell2
Synonyms:Mel91
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length819 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Subcellular location

Secreted By similarity.

Sequence similarities

Contains 6 EGF-like domains.

Contains 1 laminin G-like domain.

Contains 2 VWFC domains.

Caution

It is uncertain whether Met-1 or Met-4 is the initiator.

Ontologies

Keywords
   Cellular componentSecreted
   DomainEGF-like domain
Repeat
Signal
   LigandCalcium
   PTMDisulfide bond
Glycoprotein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Cellular_componentextracellular region

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functioncalcium ion binding

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2424 Potential
Chain25 – 819795Protein kinase C-binding protein NELL2
PRO_0000007667

Regions

Domain67 – 231165Laminin G-like
Domain275 – 33460VWFC 1
Domain400 – 44243EGF-like 1
Domain443 – 48442EGF-like 2; calcium-binding Potential
Domain485 – 52541EGF-like 3; calcium-binding Potential
Domain526 – 55631EGF-like 4
Domain558 – 60447EGF-like 5; calcium-binding Potential
Domain605 – 64036EGF-like 6; calcium-binding Potential
Domain701 – 75959VWFC 2

Amino acid modifications

Glycosylation561N-linked (GlcNAc...) Potential
Glycosylation2281N-linked (GlcNAc...) Potential
Glycosylation2961N-linked (GlcNAc...) Potential
Glycosylation3011N-linked (GlcNAc...) Potential
Glycosylation5201N-linked (GlcNAc...) Potential
Glycosylation6181N-linked (GlcNAc...) Potential
Glycosylation6381N-linked (GlcNAc...) Potential
Disulfide bond404 ↔ 416 By similarity
Disulfide bond410 ↔ 425 By similarity
Disulfide bond427 ↔ 441 By similarity
Disulfide bond447 ↔ 460 By similarity
Disulfide bond454 ↔ 469 By similarity
Disulfide bond471 ↔ 483 By similarity
Disulfide bond489 ↔ 502 By similarity
Disulfide bond496 ↔ 511 By similarity
Disulfide bond513 ↔ 524 By similarity
Disulfide bond528 ↔ 538 By similarity
Disulfide bond532 ↔ 544 By similarity
Disulfide bond546 ↔ 555 By similarity
Disulfide bond562 ↔ 575 By similarity
Disulfide bond569 ↔ 584 By similarity
Disulfide bond586 ↔ 603 By similarity
Disulfide bond609 ↔ 622 By similarity
Disulfide bond616 ↔ 631 By similarity
Disulfide bond633 ↔ 639 By similarity

Experimental info

Sequence conflict811F → L in AAB02924. Ref.1
Sequence conflict1831S → F in AAB02924. Ref.1
Sequence conflict1871P → A in AAB02924. Ref.1
Sequence conflict3521V → A in AAB02924. Ref.1
Sequence conflict4231A → V in AAB02924. Ref.1
Sequence conflict4701I → V in AAB02924. Ref.1
Sequence conflict4921N → T in AAB02924. Ref.1
Sequence conflict6681C → W in AAB02924. Ref.1
Sequence conflict6871V → D in AAB02924. Ref.1

Sequences

Sequence LengthMass (Da)Tools
Q61220 [UniParc].

Last modified September 18, 2013. Version 3.
Checksum: 530ECD363029571D

FASTA81991,432
        10         20         30         40         50         60 
MHAMESRVLL RTFCVILGLG AVWGLGVDPS LQIDVLTELE LGESTDGVRQ VPGLHNGTKA 

        70         80         90        100        110        120 
FLFQESPRSI KASTATAERF FQKLRNKHEF TILVTLKQIH LNSGVILSIH HLDHRYLELE 

       130        140        150        160        170        180 
SSGHRNEIRL HYRSGTHRPH TEVFPYILAD AKWHKLSLAF SASHLILHID CNKIYERVVE 

       190        200        210        220        230        240 
MPSTDLPLGT TFWLGQRNNA HGYFKGIMQD VHVLVMPQGF IAQCPDLNRT CPTCNDFHGL 

       250        260        270        280        290        300 
VQKIMELQDI LSKTSAKLSR AEQRMNRLDQ CYCERTCTVK GTTYRESESW TDGCKNCTCL 

       310        320        330        340        350        360 
NGTIQCETLV CPAPDCPPKS APAYVDGKCC KECKSTCQFQ GRSYFEGERN TVYSSSGMCV 

       370        380        390        400        410        420 
LYECKDQTMK LVENIGCPPL DCPESHQIAL SHSCCKVCKG YDFCSEKHTC MENSVCRNLN 

       430        440        450        460        470        480 
DRAVCSCRDG FRALREDNAY CEDIDECAEG RHYCRENTMC VNTPGSFMCI CKTGYIRIDD 

       490        500        510        520        530        540 
YSCTEHDECL TNQHNCDENA LCFNTVGGHN CVCKPGYTGN GTTCKAFCKD GCRNGGACIA 

       550        560        570        580        590        600 
ANVCACPQGF TGPSCETDID ECSEGFVQCD SRANCINLPG WYHCECRDGY HDNGMFAPGG 

       610        620        630        640        650        660 
ESCEDIDECG TGRHSCTNDT ICFNLDGGYD CRCPHGKNCT GDCVHEGKVK HTGQIWVLEN 

       670        680        690        700        710        720 
DRCSVCSCQT GFVMCRRMVC DCENPTVDLS CCPECDPRLS SQCLHQNGET VYNSGDTWVQ 

       730        740        750        760        770        780 
DCRQCRCLQG EVDCWPLACP EVECEFSVLP ENECCPRCVT DPCQADTIRN DITKTCLDEM 

       790        800        810 
NVVRFTGSSW IKHGTECTLC QCKNGHLCCS VDPQCLQEL 

« Hide

References

« Hide 'large scale' references
[1]Elkins D.A., Rossi J.
Submitted (MAY-1996) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]"Lineage-specific biology revealed by a finished genome assembly of the mouse."
Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X., Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y., Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S. expand/collapse author list , Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R., Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K., Eichler E.E., Ponting C.P.
PLoS Biol. 7:E1000112-E1000112(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: C57BL/6J.
[3]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: C57BL/6.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
U59230 mRNA. Translation: AAB02924.1.
AC109198 Genomic DNA. No translation available.
AC163991 Genomic DNA. No translation available.
AC164402 Genomic DNA. No translation available.
BC051968 mRNA. Translation: AAH51968.1.
RefSeqXP_006521226.1. XM_006521163.1.
UniGeneMm.3959.

3D structure databases

ProteinModelPortalQ61220.
ModBaseSearch...
MobiDBSearch...

Proteomic databases

PaxDbQ61220.
PRIDEQ61220.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000075275; ENSMUSP00000074751; ENSMUSG00000022454.
ENSMUST00000166170; ENSMUSP00000131665; ENSMUSG00000022454.
GeneID54003.
KEGGmmu:54003.
UCSCuc007xjq.1. mouse.

Organism-specific databases

CTD4753.
MGIMGI:1858510. Nell2.

Phylogenomic databases

eggNOGNOG253557.
GeneTreeENSGT00710000106739.
HOVERGENHBG004805.
OMADTICFNL.
OrthoDBEOG71VSRX.
TreeFamTF323325.

Gene expression databases

CleanExMM_NELL2.
GenevestigatorQ61220.

Family and domain databases

Gene3D2.60.120.200. 1 hit.
InterProIPR008985. ConA-like_lec_gl_sf.
IPR013320. ConA-like_subgrp.
IPR000742. EG-like_dom.
IPR001881. EGF-like_Ca-bd_dom.
IPR013032. EGF-like_CS.
IPR000152. EGF-type_Asp/Asn_hydroxyl_site.
IPR018097. EGF_Ca-bd_CS.
IPR024731. EGF_dom_MSP1-like.
IPR009030. Growth_fac_rcpt_N_dom.
IPR001791. Laminin_G.
IPR001007. VWF_C.
[Graphical view]
PfamPF12947. EGF_3. 1 hit.
PF07645. EGF_CA. 3 hits.
PF02210. Laminin_G_2. 1 hit.
PF00093. VWC. 2 hits.
[Graphical view]
SMARTSM00181. EGF. 2 hits.
SM00179. EGF_CA. 3 hits.
SM00282. LamG. 1 hit.
SM00210. TSPN. 1 hit.
SM00214. VWC. 3 hits.
[Graphical view]
SUPFAMSSF49899. SSF49899. 1 hit.
SSF57184. SSF57184. 2 hits.
PROSITEPS00010. ASX_HYDROXYL. 3 hits.
PS00022. EGF_1. 1 hit.
PS01186. EGF_2. 4 hits.
PS50026. EGF_3. 6 hits.
PS01187. EGF_CA. 3 hits.
PS01208. VWFC_1. 2 hits.
PS50184. VWFC_2. 3 hits.
[Graphical view]
ProtoNetSearch...

Other

NextBio310889.
PROQ61220.
SOURCESearch...

Entry information

Entry nameNELL2_MOUSE
AccessionPrimary (citable) accession number: Q61220
Secondary accession number(s): Q80UM5
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: September 18, 2013
Last modified: March 19, 2014
This is version 116 of the entry and version 3 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot