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Q61220

- NELL2_MOUSE

UniProt

Q61220 - NELL2_MOUSE

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Protein

Protein kinase C-binding protein NELL2

Gene

Nell2

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

  1. calcium ion binding Source: InterPro
Complete GO annotation...

Keywords - Ligandi

Calcium

Names & Taxonomyi

Protein namesi
Recommended name:
Protein kinase C-binding protein NELL2
Alternative name(s):
MEL91 protein
NEL-like protein 2
Gene namesi
Name:Nell2
Synonyms:Mel91
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 15

Organism-specific databases

MGIiMGI:1858510. Nell2.

Subcellular locationi

Secreted By similarity

GO - Cellular componenti

  1. extracellular region Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2424Sequence AnalysisAdd
BLAST
Chaini25 – 819795Protein kinase C-binding protein NELL2PRO_0000007667Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi56 – 561N-linked (GlcNAc...)Sequence Analysis
Glycosylationi228 – 2281N-linked (GlcNAc...)Sequence Analysis
Glycosylationi296 – 2961N-linked (GlcNAc...)Sequence Analysis
Glycosylationi301 – 3011N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi404 ↔ 416PROSITE-ProRule annotation
Disulfide bondi410 ↔ 425PROSITE-ProRule annotation
Disulfide bondi427 ↔ 441PROSITE-ProRule annotation
Disulfide bondi447 ↔ 460PROSITE-ProRule annotation
Disulfide bondi454 ↔ 469PROSITE-ProRule annotation
Disulfide bondi471 ↔ 483PROSITE-ProRule annotation
Disulfide bondi489 ↔ 502PROSITE-ProRule annotation
Disulfide bondi496 ↔ 511PROSITE-ProRule annotation
Disulfide bondi513 ↔ 524PROSITE-ProRule annotation
Glycosylationi520 – 5201N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi528 ↔ 538PROSITE-ProRule annotation
Disulfide bondi532 ↔ 544PROSITE-ProRule annotation
Disulfide bondi546 ↔ 555PROSITE-ProRule annotation
Disulfide bondi562 ↔ 575PROSITE-ProRule annotation
Disulfide bondi569 ↔ 584PROSITE-ProRule annotation
Disulfide bondi586 ↔ 603PROSITE-ProRule annotation
Disulfide bondi609 ↔ 622PROSITE-ProRule annotation
Disulfide bondi616 ↔ 631PROSITE-ProRule annotation
Glycosylationi618 – 6181N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi633 ↔ 639PROSITE-ProRule annotation
Glycosylationi638 – 6381N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ61220.
PRIDEiQ61220.

Expressioni

Gene expression databases

CleanExiMM_NELL2.
ExpressionAtlasiQ61220. baseline and differential.
GenevestigatoriQ61220.

Structurei

3D structure databases

ProteinModelPortaliQ61220.
SMRiQ61220. Positions 377-639.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini67 – 231165Laminin G-likeAdd
BLAST
Domaini275 – 33460VWFC 1PROSITE-ProRule annotationAdd
BLAST
Domaini400 – 44243EGF-like 1PROSITE-ProRule annotationAdd
BLAST
Domaini443 – 48442EGF-like 2; calcium-bindingPROSITE-ProRule annotationAdd
BLAST
Domaini485 – 52541EGF-like 3; calcium-bindingPROSITE-ProRule annotationAdd
BLAST
Domaini526 – 55631EGF-like 4PROSITE-ProRule annotationAdd
BLAST
Domaini558 – 60447EGF-like 5; calcium-bindingPROSITE-ProRule annotationAdd
BLAST
Domaini605 – 64036EGF-like 6; calcium-bindingPROSITE-ProRule annotationAdd
BLAST
Domaini701 – 75959VWFC 2PROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 6 EGF-like domains.PROSITE-ProRule annotation
Contains 1 laminin G-like domain.Curated
Contains 2 VWFC domains.PROSITE-ProRule annotation

Keywords - Domaini

EGF-like domain, Repeat, Signal

Phylogenomic databases

eggNOGiNOG253557.
GeneTreeiENSGT00770000120551.
HOVERGENiHBG004805.
InParanoidiQ61220.
OMAiDTICFNL.
OrthoDBiEOG71VSRX.
TreeFamiTF323325.

Family and domain databases

Gene3Di2.60.120.200. 1 hit.
InterProiIPR013320. ConA-like_dom.
IPR000742. EG-like_dom.
IPR001881. EGF-like_Ca-bd_dom.
IPR013032. EGF-like_CS.
IPR000152. EGF-type_Asp/Asn_hydroxyl_site.
IPR018097. EGF_Ca-bd_CS.
IPR024731. EGF_dom_MSP1-like.
IPR009030. Growth_fac_rcpt_N_dom.
IPR001791. Laminin_G.
IPR001007. VWF_C.
[Graphical view]
PfamiPF12947. EGF_3. 1 hit.
PF07645. EGF_CA. 3 hits.
PF02210. Laminin_G_2. 1 hit.
PF00093. VWC. 2 hits.
[Graphical view]
SMARTiSM00181. EGF. 2 hits.
SM00179. EGF_CA. 3 hits.
SM00282. LamG. 1 hit.
SM00210. TSPN. 1 hit.
SM00214. VWC. 3 hits.
[Graphical view]
SUPFAMiSSF49899. SSF49899. 1 hit.
SSF57184. SSF57184. 2 hits.
PROSITEiPS00010. ASX_HYDROXYL. 3 hits.
PS00022. EGF_1. 1 hit.
PS01186. EGF_2. 4 hits.
PS50026. EGF_3. 6 hits.
PS01187. EGF_CA. 3 hits.
PS01208. VWFC_1. 2 hits.
PS50184. VWFC_2. 3 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q61220-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MHAMESRVLL RTFCVILGLG AVWGLGVDPS LQIDVLTELE LGESTDGVRQ
60 70 80 90 100
VPGLHNGTKA FLFQESPRSI KASTATAERF FQKLRNKHEF TILVTLKQIH
110 120 130 140 150
LNSGVILSIH HLDHRYLELE SSGHRNEIRL HYRSGTHRPH TEVFPYILAD
160 170 180 190 200
AKWHKLSLAF SASHLILHID CNKIYERVVE MPSTDLPLGT TFWLGQRNNA
210 220 230 240 250
HGYFKGIMQD VHVLVMPQGF IAQCPDLNRT CPTCNDFHGL VQKIMELQDI
260 270 280 290 300
LSKTSAKLSR AEQRMNRLDQ CYCERTCTVK GTTYRESESW TDGCKNCTCL
310 320 330 340 350
NGTIQCETLV CPAPDCPPKS APAYVDGKCC KECKSTCQFQ GRSYFEGERN
360 370 380 390 400
TVYSSSGMCV LYECKDQTMK LVENIGCPPL DCPESHQIAL SHSCCKVCKG
410 420 430 440 450
YDFCSEKHTC MENSVCRNLN DRAVCSCRDG FRALREDNAY CEDIDECAEG
460 470 480 490 500
RHYCRENTMC VNTPGSFMCI CKTGYIRIDD YSCTEHDECL TNQHNCDENA
510 520 530 540 550
LCFNTVGGHN CVCKPGYTGN GTTCKAFCKD GCRNGGACIA ANVCACPQGF
560 570 580 590 600
TGPSCETDID ECSEGFVQCD SRANCINLPG WYHCECRDGY HDNGMFAPGG
610 620 630 640 650
ESCEDIDECG TGRHSCTNDT ICFNLDGGYD CRCPHGKNCT GDCVHEGKVK
660 670 680 690 700
HTGQIWVLEN DRCSVCSCQT GFVMCRRMVC DCENPTVDLS CCPECDPRLS
710 720 730 740 750
SQCLHQNGET VYNSGDTWVQ DCRQCRCLQG EVDCWPLACP EVECEFSVLP
760 770 780 790 800
ENECCPRCVT DPCQADTIRN DITKTCLDEM NVVRFTGSSW IKHGTECTLC
810
QCKNGHLCCS VDPQCLQEL
Length:819
Mass (Da):91,432
Last modified:September 18, 2013 - v3
Checksum:i530ECD363029571D
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti81 – 811F → L in AAB02924. 1 PublicationCurated
Sequence conflicti183 – 1831S → F in AAB02924. 1 PublicationCurated
Sequence conflicti187 – 1871P → A in AAB02924. 1 PublicationCurated
Sequence conflicti352 – 3521V → A in AAB02924. 1 PublicationCurated
Sequence conflicti423 – 4231A → V in AAB02924. 1 PublicationCurated
Sequence conflicti470 – 4701I → V in AAB02924. 1 PublicationCurated
Sequence conflicti492 – 4921N → T in AAB02924. 1 PublicationCurated
Sequence conflicti668 – 6681C → W in AAB02924. 1 PublicationCurated
Sequence conflicti687 – 6871V → D in AAB02924. 1 PublicationCurated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U59230 mRNA. Translation: AAB02924.1.
AC109198 Genomic DNA. No translation available.
AC163991 Genomic DNA. No translation available.
AC164402 Genomic DNA. No translation available.
BC051968 mRNA. Translation: AAH51968.1.
CCDSiCCDS27775.1.
RefSeqiNP_001276582.1. NM_001289653.1.
XP_006521226.1. XM_006521163.1.
UniGeneiMm.3959.

Genome annotation databases

EnsembliENSMUST00000075275; ENSMUSP00000074751; ENSMUSG00000022454.
ENSMUST00000166170; ENSMUSP00000131665; ENSMUSG00000022454.
GeneIDi54003.
KEGGimmu:54003.
UCSCiuc007xjq.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U59230 mRNA. Translation: AAB02924.1 .
AC109198 Genomic DNA. No translation available.
AC163991 Genomic DNA. No translation available.
AC164402 Genomic DNA. No translation available.
BC051968 mRNA. Translation: AAH51968.1 .
CCDSi CCDS27775.1.
RefSeqi NP_001276582.1. NM_001289653.1.
XP_006521226.1. XM_006521163.1.
UniGenei Mm.3959.

3D structure databases

ProteinModelPortali Q61220.
SMRi Q61220. Positions 377-639.
ModBasei Search...
MobiDBi Search...

Proteomic databases

PaxDbi Q61220.
PRIDEi Q61220.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000075275 ; ENSMUSP00000074751 ; ENSMUSG00000022454 .
ENSMUST00000166170 ; ENSMUSP00000131665 ; ENSMUSG00000022454 .
GeneIDi 54003.
KEGGi mmu:54003.
UCSCi uc007xjq.1. mouse.

Organism-specific databases

CTDi 4753.
MGIi MGI:1858510. Nell2.

Phylogenomic databases

eggNOGi NOG253557.
GeneTreei ENSGT00770000120551.
HOVERGENi HBG004805.
InParanoidi Q61220.
OMAi DTICFNL.
OrthoDBi EOG71VSRX.
TreeFami TF323325.

Miscellaneous databases

NextBioi 310889.
PROi Q61220.
SOURCEi Search...

Gene expression databases

CleanExi MM_NELL2.
ExpressionAtlasi Q61220. baseline and differential.
Genevestigatori Q61220.

Family and domain databases

Gene3Di 2.60.120.200. 1 hit.
InterProi IPR013320. ConA-like_dom.
IPR000742. EG-like_dom.
IPR001881. EGF-like_Ca-bd_dom.
IPR013032. EGF-like_CS.
IPR000152. EGF-type_Asp/Asn_hydroxyl_site.
IPR018097. EGF_Ca-bd_CS.
IPR024731. EGF_dom_MSP1-like.
IPR009030. Growth_fac_rcpt_N_dom.
IPR001791. Laminin_G.
IPR001007. VWF_C.
[Graphical view ]
Pfami PF12947. EGF_3. 1 hit.
PF07645. EGF_CA. 3 hits.
PF02210. Laminin_G_2. 1 hit.
PF00093. VWC. 2 hits.
[Graphical view ]
SMARTi SM00181. EGF. 2 hits.
SM00179. EGF_CA. 3 hits.
SM00282. LamG. 1 hit.
SM00210. TSPN. 1 hit.
SM00214. VWC. 3 hits.
[Graphical view ]
SUPFAMi SSF49899. SSF49899. 1 hit.
SSF57184. SSF57184. 2 hits.
PROSITEi PS00010. ASX_HYDROXYL. 3 hits.
PS00022. EGF_1. 1 hit.
PS01186. EGF_2. 4 hits.
PS50026. EGF_3. 6 hits.
PS01187. EGF_CA. 3 hits.
PS01208. VWFC_1. 2 hits.
PS50184. VWFC_2. 3 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Elkins D.A., Rossi J.
    Submitted (MAY-1996) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6.

Entry informationi

Entry nameiNELL2_MOUSE
AccessioniPrimary (citable) accession number: Q61220
Secondary accession number(s): Q80UM5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: September 18, 2013
Last modified: November 26, 2014
This is version 123 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Caution

It is uncertain whether Met-1 or Met-4 is the initiator.Curated

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3