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Protein

Protein kinase C-binding protein NELL2

Gene

Nell2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Required for neuron survival through the modulation of MAPK pathways (By similarity). Involved in the regulation of hypothalamic GNRH secretion and the control of puberty (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Ligandi

Calcium

Names & Taxonomyi

Protein namesi
Recommended name:
Protein kinase C-binding protein NELL2
Alternative name(s):
MEL91 protein
NEL-like protein 2
Gene namesi
Name:Nell2
Synonyms:Mel91
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 15

Organism-specific databases

MGIiMGI:1858510. Nell2.

Subcellular locationi

  • Secreted By similarity

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 24Sequence analysisAdd BLAST24
ChainiPRO_000000766725 – 819Protein kinase C-binding protein NELL2Add BLAST795

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi56N-linked (GlcNAc...)Sequence analysis1
Glycosylationi228N-linked (GlcNAc...)Sequence analysis1
Glycosylationi296N-linked (GlcNAc...)Sequence analysis1
Glycosylationi301N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi404 ↔ 416PROSITE-ProRule annotation
Disulfide bondi410 ↔ 425PROSITE-ProRule annotation
Disulfide bondi427 ↔ 441PROSITE-ProRule annotation
Disulfide bondi447 ↔ 460PROSITE-ProRule annotation
Disulfide bondi454 ↔ 469PROSITE-ProRule annotation
Disulfide bondi471 ↔ 483PROSITE-ProRule annotation
Disulfide bondi489 ↔ 502PROSITE-ProRule annotation
Disulfide bondi496 ↔ 511PROSITE-ProRule annotation
Disulfide bondi513 ↔ 524PROSITE-ProRule annotation
Glycosylationi520N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi528 ↔ 538PROSITE-ProRule annotation
Disulfide bondi532 ↔ 544PROSITE-ProRule annotation
Disulfide bondi546 ↔ 555PROSITE-ProRule annotation
Disulfide bondi562 ↔ 575PROSITE-ProRule annotation
Disulfide bondi569 ↔ 584PROSITE-ProRule annotation
Disulfide bondi586 ↔ 603PROSITE-ProRule annotation
Disulfide bondi609 ↔ 622PROSITE-ProRule annotation
Disulfide bondi616 ↔ 631PROSITE-ProRule annotation
Glycosylationi618N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi633 ↔ 639PROSITE-ProRule annotation
Glycosylationi638N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ61220.
PeptideAtlasiQ61220.
PRIDEiQ61220.

PTM databases

PhosphoSitePlusiQ61220.

Expressioni

Gene expression databases

BgeeiENSMUSG00000022454.
CleanExiMM_NELL2.
GenevisibleiQ61220. MM.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000074751.

Structurei

3D structure databases

ProteinModelPortaliQ61220.
SMRiQ61220.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini67 – 231Laminin G-likeAdd BLAST165
Domaini275 – 334VWFC 1PROSITE-ProRule annotationAdd BLAST60
Domaini400 – 442EGF-like 1PROSITE-ProRule annotationAdd BLAST43
Domaini443 – 484EGF-like 2; calcium-bindingPROSITE-ProRule annotationAdd BLAST42
Domaini485 – 525EGF-like 3; calcium-bindingPROSITE-ProRule annotationAdd BLAST41
Domaini526 – 556EGF-like 4PROSITE-ProRule annotationAdd BLAST31
Domaini558 – 604EGF-like 5; calcium-bindingPROSITE-ProRule annotationAdd BLAST47
Domaini605 – 640EGF-like 6; calcium-bindingPROSITE-ProRule annotationAdd BLAST36
Domaini701 – 759VWFC 2PROSITE-ProRule annotationAdd BLAST59

Sequence similaritiesi

Contains 6 EGF-like domains.PROSITE-ProRule annotation
Contains 1 laminin G-like domain.Curated
Contains 2 VWFC domains.PROSITE-ProRule annotation

Keywords - Domaini

EGF-like domain, Repeat, Signal

Phylogenomic databases

eggNOGiENOG410IR7C. Eukaryota.
ENOG410XSZA. LUCA.
GeneTreeiENSGT00810000125439.
HOGENOMiHOG000217920.
HOVERGENiHBG004805.
InParanoidiQ61220.
OMAiSHHPHTE.
OrthoDBiEOG091G01DI.
TreeFamiTF323325.

Family and domain databases

Gene3Di2.60.120.200. 1 hit.
InterProiIPR013320. ConA-like_dom.
IPR001881. EGF-like_Ca-bd_dom.
IPR013032. EGF-like_CS.
IPR000742. EGF-like_dom.
IPR000152. EGF-type_Asp/Asn_hydroxyl_site.
IPR018097. EGF_Ca-bd_CS.
IPR024731. EGF_dom.
IPR009030. Growth_fac_rcpt_.
IPR001791. Laminin_G.
IPR001007. VWF_dom.
[Graphical view]
PfamiPF12947. EGF_3. 1 hit.
PF07645. EGF_CA. 3 hits.
PF02210. Laminin_G_2. 1 hit.
PF00093. VWC. 2 hits.
[Graphical view]
SMARTiSM00181. EGF. 6 hits.
SM00179. EGF_CA. 5 hits.
SM00282. LamG. 1 hit.
SM00210. TSPN. 1 hit.
SM00214. VWC. 4 hits.
SM00215. VWC_out. 2 hits.
[Graphical view]
SUPFAMiSSF49899. SSF49899. 1 hit.
SSF57184. SSF57184. 2 hits.
PROSITEiPS00010. ASX_HYDROXYL. 3 hits.
PS00022. EGF_1. 1 hit.
PS01186. EGF_2. 4 hits.
PS50026. EGF_3. 6 hits.
PS01187. EGF_CA. 3 hits.
PS01208. VWFC_1. 2 hits.
PS50184. VWFC_2. 3 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q61220-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MHAMESRVLL RTFCVILGLG AVWGLGVDPS LQIDVLTELE LGESTDGVRQ
60 70 80 90 100
VPGLHNGTKA FLFQESPRSI KASTATAERF FQKLRNKHEF TILVTLKQIH
110 120 130 140 150
LNSGVILSIH HLDHRYLELE SSGHRNEIRL HYRSGTHRPH TEVFPYILAD
160 170 180 190 200
AKWHKLSLAF SASHLILHID CNKIYERVVE MPSTDLPLGT TFWLGQRNNA
210 220 230 240 250
HGYFKGIMQD VHVLVMPQGF IAQCPDLNRT CPTCNDFHGL VQKIMELQDI
260 270 280 290 300
LSKTSAKLSR AEQRMNRLDQ CYCERTCTVK GTTYRESESW TDGCKNCTCL
310 320 330 340 350
NGTIQCETLV CPAPDCPPKS APAYVDGKCC KECKSTCQFQ GRSYFEGERN
360 370 380 390 400
TVYSSSGMCV LYECKDQTMK LVENIGCPPL DCPESHQIAL SHSCCKVCKG
410 420 430 440 450
YDFCSEKHTC MENSVCRNLN DRAVCSCRDG FRALREDNAY CEDIDECAEG
460 470 480 490 500
RHYCRENTMC VNTPGSFMCI CKTGYIRIDD YSCTEHDECL TNQHNCDENA
510 520 530 540 550
LCFNTVGGHN CVCKPGYTGN GTTCKAFCKD GCRNGGACIA ANVCACPQGF
560 570 580 590 600
TGPSCETDID ECSEGFVQCD SRANCINLPG WYHCECRDGY HDNGMFAPGG
610 620 630 640 650
ESCEDIDECG TGRHSCTNDT ICFNLDGGYD CRCPHGKNCT GDCVHEGKVK
660 670 680 690 700
HTGQIWVLEN DRCSVCSCQT GFVMCRRMVC DCENPTVDLS CCPECDPRLS
710 720 730 740 750
SQCLHQNGET VYNSGDTWVQ DCRQCRCLQG EVDCWPLACP EVECEFSVLP
760 770 780 790 800
ENECCPRCVT DPCQADTIRN DITKTCLDEM NVVRFTGSSW IKHGTECTLC
810
QCKNGHLCCS VDPQCLQEL
Length:819
Mass (Da):91,432
Last modified:September 18, 2013 - v3
Checksum:i530ECD363029571D
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti81F → L in AAB02924 (Ref. 1) Curated1
Sequence conflicti183S → F in AAB02924 (Ref. 1) Curated1
Sequence conflicti187P → A in AAB02924 (Ref. 1) Curated1
Sequence conflicti352V → A in AAB02924 (Ref. 1) Curated1
Sequence conflicti423A → V in AAB02924 (Ref. 1) Curated1
Sequence conflicti470I → V in AAB02924 (Ref. 1) Curated1
Sequence conflicti492N → T in AAB02924 (Ref. 1) Curated1
Sequence conflicti668C → W in AAB02924 (Ref. 1) Curated1
Sequence conflicti687V → D in AAB02924 (Ref. 1) Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U59230 mRNA. Translation: AAB02924.1.
AC109198 Genomic DNA. No translation available.
AC163991 Genomic DNA. No translation available.
AC164402 Genomic DNA. No translation available.
BC051968 mRNA. Translation: AAH51968.1.
CCDSiCCDS27775.1.
RefSeqiNP_001276582.1. NM_001289653.1.
XP_006521226.1. XM_006521163.2.
XP_011243995.1. XM_011245693.1.
UniGeneiMm.3959.

Genome annotation databases

EnsembliENSMUST00000075275; ENSMUSP00000074751; ENSMUSG00000022454.
ENSMUST00000166170; ENSMUSP00000131665; ENSMUSG00000022454.
GeneIDi54003.
KEGGimmu:54003.
UCSCiuc007xjq.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U59230 mRNA. Translation: AAB02924.1.
AC109198 Genomic DNA. No translation available.
AC163991 Genomic DNA. No translation available.
AC164402 Genomic DNA. No translation available.
BC051968 mRNA. Translation: AAH51968.1.
CCDSiCCDS27775.1.
RefSeqiNP_001276582.1. NM_001289653.1.
XP_006521226.1. XM_006521163.2.
XP_011243995.1. XM_011245693.1.
UniGeneiMm.3959.

3D structure databases

ProteinModelPortaliQ61220.
SMRiQ61220.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000074751.

PTM databases

PhosphoSitePlusiQ61220.

Proteomic databases

PaxDbiQ61220.
PeptideAtlasiQ61220.
PRIDEiQ61220.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000075275; ENSMUSP00000074751; ENSMUSG00000022454.
ENSMUST00000166170; ENSMUSP00000131665; ENSMUSG00000022454.
GeneIDi54003.
KEGGimmu:54003.
UCSCiuc007xjq.2. mouse.

Organism-specific databases

CTDi4753.
MGIiMGI:1858510. Nell2.

Phylogenomic databases

eggNOGiENOG410IR7C. Eukaryota.
ENOG410XSZA. LUCA.
GeneTreeiENSGT00810000125439.
HOGENOMiHOG000217920.
HOVERGENiHBG004805.
InParanoidiQ61220.
OMAiSHHPHTE.
OrthoDBiEOG091G01DI.
TreeFamiTF323325.

Miscellaneous databases

PROiQ61220.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000022454.
CleanExiMM_NELL2.
GenevisibleiQ61220. MM.

Family and domain databases

Gene3Di2.60.120.200. 1 hit.
InterProiIPR013320. ConA-like_dom.
IPR001881. EGF-like_Ca-bd_dom.
IPR013032. EGF-like_CS.
IPR000742. EGF-like_dom.
IPR000152. EGF-type_Asp/Asn_hydroxyl_site.
IPR018097. EGF_Ca-bd_CS.
IPR024731. EGF_dom.
IPR009030. Growth_fac_rcpt_.
IPR001791. Laminin_G.
IPR001007. VWF_dom.
[Graphical view]
PfamiPF12947. EGF_3. 1 hit.
PF07645. EGF_CA. 3 hits.
PF02210. Laminin_G_2. 1 hit.
PF00093. VWC. 2 hits.
[Graphical view]
SMARTiSM00181. EGF. 6 hits.
SM00179. EGF_CA. 5 hits.
SM00282. LamG. 1 hit.
SM00210. TSPN. 1 hit.
SM00214. VWC. 4 hits.
SM00215. VWC_out. 2 hits.
[Graphical view]
SUPFAMiSSF49899. SSF49899. 1 hit.
SSF57184. SSF57184. 2 hits.
PROSITEiPS00010. ASX_HYDROXYL. 3 hits.
PS00022. EGF_1. 1 hit.
PS01186. EGF_2. 4 hits.
PS50026. EGF_3. 6 hits.
PS01187. EGF_CA. 3 hits.
PS01208. VWFC_1. 2 hits.
PS50184. VWFC_2. 3 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiNELL2_MOUSE
AccessioniPrimary (citable) accession number: Q61220
Secondary accession number(s): Q80UM5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: September 18, 2013
Last modified: November 2, 2016
This is version 138 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Caution

It is uncertain whether Met-1 or Met-4 is the initiator.Curated

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.