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Q61220

- NELL2_MOUSE

UniProt

Q61220 - NELL2_MOUSE

Protein

Protein kinase C-binding protein NELL2

Gene

Nell2

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 121 (01 Oct 2014)
      Sequence version 3 (18 Sep 2013)
      Previous versions | rss
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    Functioni

    GO - Molecular functioni

    1. calcium ion binding Source: InterPro

    Keywords - Ligandi

    Calcium

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Protein kinase C-binding protein NELL2
    Alternative name(s):
    MEL91 protein
    NEL-like protein 2
    Gene namesi
    Name:Nell2
    Synonyms:Mel91
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 15

    Organism-specific databases

    MGIiMGI:1858510. Nell2.

    Subcellular locationi

    Secreted By similarity

    GO - Cellular componenti

    1. extracellular region Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Secreted

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2424Sequence AnalysisAdd
    BLAST
    Chaini25 – 819795Protein kinase C-binding protein NELL2PRO_0000007667Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi56 – 561N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi228 – 2281N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi296 – 2961N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi301 – 3011N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi404 ↔ 416PROSITE-ProRule annotation
    Disulfide bondi410 ↔ 425PROSITE-ProRule annotation
    Disulfide bondi427 ↔ 441PROSITE-ProRule annotation
    Disulfide bondi447 ↔ 460PROSITE-ProRule annotation
    Disulfide bondi454 ↔ 469PROSITE-ProRule annotation
    Disulfide bondi471 ↔ 483PROSITE-ProRule annotation
    Disulfide bondi489 ↔ 502PROSITE-ProRule annotation
    Disulfide bondi496 ↔ 511PROSITE-ProRule annotation
    Disulfide bondi513 ↔ 524PROSITE-ProRule annotation
    Glycosylationi520 – 5201N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi528 ↔ 538PROSITE-ProRule annotation
    Disulfide bondi532 ↔ 544PROSITE-ProRule annotation
    Disulfide bondi546 ↔ 555PROSITE-ProRule annotation
    Disulfide bondi562 ↔ 575PROSITE-ProRule annotation
    Disulfide bondi569 ↔ 584PROSITE-ProRule annotation
    Disulfide bondi586 ↔ 603PROSITE-ProRule annotation
    Disulfide bondi609 ↔ 622PROSITE-ProRule annotation
    Disulfide bondi616 ↔ 631PROSITE-ProRule annotation
    Glycosylationi618 – 6181N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi633 ↔ 639PROSITE-ProRule annotation
    Glycosylationi638 – 6381N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    PaxDbiQ61220.
    PRIDEiQ61220.

    Expressioni

    Gene expression databases

    CleanExiMM_NELL2.
    GenevestigatoriQ61220.

    Structurei

    3D structure databases

    ProteinModelPortaliQ61220.
    SMRiQ61220. Positions 377-639.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini67 – 231165Laminin G-likeAdd
    BLAST
    Domaini275 – 33460VWFC 1PROSITE-ProRule annotationAdd
    BLAST
    Domaini400 – 44243EGF-like 1PROSITE-ProRule annotationAdd
    BLAST
    Domaini443 – 48442EGF-like 2; calcium-bindingPROSITE-ProRule annotationAdd
    BLAST
    Domaini485 – 52541EGF-like 3; calcium-bindingPROSITE-ProRule annotationAdd
    BLAST
    Domaini526 – 55631EGF-like 4PROSITE-ProRule annotationAdd
    BLAST
    Domaini558 – 60447EGF-like 5; calcium-bindingPROSITE-ProRule annotationAdd
    BLAST
    Domaini605 – 64036EGF-like 6; calcium-bindingPROSITE-ProRule annotationAdd
    BLAST
    Domaini701 – 75959VWFC 2PROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Contains 6 EGF-like domains.PROSITE-ProRule annotation
    Contains 1 laminin G-like domain.Curated
    Contains 2 VWFC domains.PROSITE-ProRule annotation

    Keywords - Domaini

    EGF-like domain, Repeat, Signal

    Phylogenomic databases

    eggNOGiNOG253557.
    GeneTreeiENSGT00750000117321.
    HOVERGENiHBG004805.
    OMAiDTICFNL.
    OrthoDBiEOG71VSRX.
    TreeFamiTF323325.

    Family and domain databases

    Gene3Di2.60.120.200. 1 hit.
    InterProiIPR008985. ConA-like_lec_gl_sf.
    IPR013320. ConA-like_subgrp.
    IPR000742. EG-like_dom.
    IPR001881. EGF-like_Ca-bd_dom.
    IPR013032. EGF-like_CS.
    IPR000152. EGF-type_Asp/Asn_hydroxyl_site.
    IPR018097. EGF_Ca-bd_CS.
    IPR024731. EGF_dom_MSP1-like.
    IPR009030. Growth_fac_rcpt_N_dom.
    IPR001791. Laminin_G.
    IPR001007. VWF_C.
    [Graphical view]
    PfamiPF12947. EGF_3. 1 hit.
    PF07645. EGF_CA. 3 hits.
    PF02210. Laminin_G_2. 1 hit.
    PF00093. VWC. 2 hits.
    [Graphical view]
    SMARTiSM00181. EGF. 2 hits.
    SM00179. EGF_CA. 3 hits.
    SM00282. LamG. 1 hit.
    SM00210. TSPN. 1 hit.
    SM00214. VWC. 3 hits.
    [Graphical view]
    SUPFAMiSSF49899. SSF49899. 1 hit.
    SSF57184. SSF57184. 2 hits.
    PROSITEiPS00010. ASX_HYDROXYL. 3 hits.
    PS00022. EGF_1. 1 hit.
    PS01186. EGF_2. 4 hits.
    PS50026. EGF_3. 6 hits.
    PS01187. EGF_CA. 3 hits.
    PS01208. VWFC_1. 2 hits.
    PS50184. VWFC_2. 3 hits.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q61220-1 [UniParc]FASTAAdd to Basket

    « Hide

    MHAMESRVLL RTFCVILGLG AVWGLGVDPS LQIDVLTELE LGESTDGVRQ    50
    VPGLHNGTKA FLFQESPRSI KASTATAERF FQKLRNKHEF TILVTLKQIH 100
    LNSGVILSIH HLDHRYLELE SSGHRNEIRL HYRSGTHRPH TEVFPYILAD 150
    AKWHKLSLAF SASHLILHID CNKIYERVVE MPSTDLPLGT TFWLGQRNNA 200
    HGYFKGIMQD VHVLVMPQGF IAQCPDLNRT CPTCNDFHGL VQKIMELQDI 250
    LSKTSAKLSR AEQRMNRLDQ CYCERTCTVK GTTYRESESW TDGCKNCTCL 300
    NGTIQCETLV CPAPDCPPKS APAYVDGKCC KECKSTCQFQ GRSYFEGERN 350
    TVYSSSGMCV LYECKDQTMK LVENIGCPPL DCPESHQIAL SHSCCKVCKG 400
    YDFCSEKHTC MENSVCRNLN DRAVCSCRDG FRALREDNAY CEDIDECAEG 450
    RHYCRENTMC VNTPGSFMCI CKTGYIRIDD YSCTEHDECL TNQHNCDENA 500
    LCFNTVGGHN CVCKPGYTGN GTTCKAFCKD GCRNGGACIA ANVCACPQGF 550
    TGPSCETDID ECSEGFVQCD SRANCINLPG WYHCECRDGY HDNGMFAPGG 600
    ESCEDIDECG TGRHSCTNDT ICFNLDGGYD CRCPHGKNCT GDCVHEGKVK 650
    HTGQIWVLEN DRCSVCSCQT GFVMCRRMVC DCENPTVDLS CCPECDPRLS 700
    SQCLHQNGET VYNSGDTWVQ DCRQCRCLQG EVDCWPLACP EVECEFSVLP 750
    ENECCPRCVT DPCQADTIRN DITKTCLDEM NVVRFTGSSW IKHGTECTLC 800
    QCKNGHLCCS VDPQCLQEL 819
    Length:819
    Mass (Da):91,432
    Last modified:September 18, 2013 - v3
    Checksum:i530ECD363029571D
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti81 – 811F → L in AAB02924. 1 PublicationCurated
    Sequence conflicti183 – 1831S → F in AAB02924. 1 PublicationCurated
    Sequence conflicti187 – 1871P → A in AAB02924. 1 PublicationCurated
    Sequence conflicti352 – 3521V → A in AAB02924. 1 PublicationCurated
    Sequence conflicti423 – 4231A → V in AAB02924. 1 PublicationCurated
    Sequence conflicti470 – 4701I → V in AAB02924. 1 PublicationCurated
    Sequence conflicti492 – 4921N → T in AAB02924. 1 PublicationCurated
    Sequence conflicti668 – 6681C → W in AAB02924. 1 PublicationCurated
    Sequence conflicti687 – 6871V → D in AAB02924. 1 PublicationCurated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U59230 mRNA. Translation: AAB02924.1.
    AC109198 Genomic DNA. No translation available.
    AC163991 Genomic DNA. No translation available.
    AC164402 Genomic DNA. No translation available.
    BC051968 mRNA. Translation: AAH51968.1.
    CCDSiCCDS27775.1.
    RefSeqiNP_001276582.1. NM_001289653.1.
    XP_006521226.1. XM_006521163.1.
    UniGeneiMm.3959.

    Genome annotation databases

    EnsembliENSMUST00000075275; ENSMUSP00000074751; ENSMUSG00000022454.
    ENSMUST00000166170; ENSMUSP00000131665; ENSMUSG00000022454.
    GeneIDi54003.
    KEGGimmu:54003.
    UCSCiuc007xjq.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U59230 mRNA. Translation: AAB02924.1 .
    AC109198 Genomic DNA. No translation available.
    AC163991 Genomic DNA. No translation available.
    AC164402 Genomic DNA. No translation available.
    BC051968 mRNA. Translation: AAH51968.1 .
    CCDSi CCDS27775.1.
    RefSeqi NP_001276582.1. NM_001289653.1.
    XP_006521226.1. XM_006521163.1.
    UniGenei Mm.3959.

    3D structure databases

    ProteinModelPortali Q61220.
    SMRi Q61220. Positions 377-639.
    ModBasei Search...
    MobiDBi Search...

    Proteomic databases

    PaxDbi Q61220.
    PRIDEi Q61220.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000075275 ; ENSMUSP00000074751 ; ENSMUSG00000022454 .
    ENSMUST00000166170 ; ENSMUSP00000131665 ; ENSMUSG00000022454 .
    GeneIDi 54003.
    KEGGi mmu:54003.
    UCSCi uc007xjq.1. mouse.

    Organism-specific databases

    CTDi 4753.
    MGIi MGI:1858510. Nell2.

    Phylogenomic databases

    eggNOGi NOG253557.
    GeneTreei ENSGT00750000117321.
    HOVERGENi HBG004805.
    OMAi DTICFNL.
    OrthoDBi EOG71VSRX.
    TreeFami TF323325.

    Miscellaneous databases

    NextBioi 310889.
    PROi Q61220.
    SOURCEi Search...

    Gene expression databases

    CleanExi MM_NELL2.
    Genevestigatori Q61220.

    Family and domain databases

    Gene3Di 2.60.120.200. 1 hit.
    InterProi IPR008985. ConA-like_lec_gl_sf.
    IPR013320. ConA-like_subgrp.
    IPR000742. EG-like_dom.
    IPR001881. EGF-like_Ca-bd_dom.
    IPR013032. EGF-like_CS.
    IPR000152. EGF-type_Asp/Asn_hydroxyl_site.
    IPR018097. EGF_Ca-bd_CS.
    IPR024731. EGF_dom_MSP1-like.
    IPR009030. Growth_fac_rcpt_N_dom.
    IPR001791. Laminin_G.
    IPR001007. VWF_C.
    [Graphical view ]
    Pfami PF12947. EGF_3. 1 hit.
    PF07645. EGF_CA. 3 hits.
    PF02210. Laminin_G_2. 1 hit.
    PF00093. VWC. 2 hits.
    [Graphical view ]
    SMARTi SM00181. EGF. 2 hits.
    SM00179. EGF_CA. 3 hits.
    SM00282. LamG. 1 hit.
    SM00210. TSPN. 1 hit.
    SM00214. VWC. 3 hits.
    [Graphical view ]
    SUPFAMi SSF49899. SSF49899. 1 hit.
    SSF57184. SSF57184. 2 hits.
    PROSITEi PS00010. ASX_HYDROXYL. 3 hits.
    PS00022. EGF_1. 1 hit.
    PS01186. EGF_2. 4 hits.
    PS50026. EGF_3. 6 hits.
    PS01187. EGF_CA. 3 hits.
    PS01208. VWFC_1. 2 hits.
    PS50184. VWFC_2. 3 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Elkins D.A., Rossi J.
      Submitted (MAY-1996) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: C57BL/6J.
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6.

    Entry informationi

    Entry nameiNELL2_MOUSE
    AccessioniPrimary (citable) accession number: Q61220
    Secondary accession number(s): Q80UM5
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1997
    Last sequence update: September 18, 2013
    Last modified: October 1, 2014
    This is version 121 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Caution

    It is uncertain whether Met-1 or Met-4 is the initiator.Curated

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3