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Q61216

- MRE11_MOUSE

UniProt

Q61216 - MRE11_MOUSE

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Protein
Double-strand break repair protein MRE11A
Gene
Mre11a, Mre11
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Component of the MRN complex, which plays a central role in double-strand break (DSB) repair, DNA recombination, maintenance of telomere integrity and meiosis. The complex possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity, which are provided by MRE11A. RAD50 may be required to bind DNA ends and hold them in close proximity. This could facilitate searches for short or long regions of sequence homology in the recombining DNA templates, and may also stimulate the activity of DNA ligases and/or restrict the nuclease activity of MRE11A to prevent nucleolytic degradation past a given point. The complex may also be required for DNA damage signaling via activation of the ATM kinase. In telomeres the MRN complex may modulate t-loop formation By similarity.

Cofactori

Manganese By similarity.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei129 – 1291Proton donor By similarity

GO - Molecular functioni

  1. 3'-5' exonuclease activity Source: RefGenome
  2. ATP-dependent DNA helicase activity Source: Ensembl
  3. DNA binding Source: Ensembl
  4. endonuclease activity Source: RefGenome
  5. manganese ion binding Source: InterPro

GO - Biological processi

  1. base-excision repair Source: RefGenome
  2. cell proliferation Source: MGI
  3. cellular response to DNA damage stimulus Source: MGI
  4. chromosome organization Source: MGI
  5. double-strand break repair Source: MGI
  6. intra-S DNA damage checkpoint Source: MGI
  7. mitotic G2 DNA damage checkpoint Source: MGI
  8. negative regulation of DNA endoreduplication Source: Ensembl
  9. nucleic acid phosphodiester bond hydrolysis Source: GOC
  10. nucleotide-excision repair Source: RefGenome
  11. positive regulation of kinase activity Source: Ensembl
  12. positive regulation of protein autophosphorylation Source: Ensembl
  13. sister chromatid cohesion Source: Ensembl
  14. synapsis Source: MGI
  15. telomere maintenance Source: RefGenome
Complete GO annotation...

Keywords - Molecular functioni

Endonuclease, Exonuclease, Hydrolase, Nuclease

Keywords - Biological processi

DNA damage, DNA repair, Meiosis

Keywords - Ligandi

Manganese

Enzyme and pathway databases

ReactomeiREACT_188819. DNA Damage/Telomere Stress Induced Senescence.
REACT_196447. IRF3-mediated induction of type I IFN.

Names & Taxonomyi

Protein namesi
Recommended name:
Double-strand break repair protein MRE11A
Short name:
MmMRE11A
Alternative name(s):
Meiotic recombination 11 homolog 1
Short name:
MRE11 homolog 1
Meiotic recombination 11 homolog A
Short name:
MRE11 homolog A
Gene namesi
Name:Mre11a
Synonyms:Mre11
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 9

Organism-specific databases

MGIiMGI:1100512. Mre11a.

Subcellular locationi

Nucleus By similarity
Note: Localizes to discrete nuclear foci after treatment with genotoxic agents By similarity.

GO - Cellular componenti

  1. Mre11 complex Source: RefGenome
  2. chromatin Source: RefGenome
  3. chromosome, telomeric region Source: Ensembl
  4. nucleus Source: MGI
  5. site of double-strand break Source: RefGenome
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11Removed By similarity
Chaini2 – 706705Double-strand break repair protein MRE11A
PRO_0000138674Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylserine By similarity
Modified residuei2 – 21Phosphoserine1 Publication
Modified residuei648 – 6481Phosphoserine By similarity
Modified residuei686 – 6861Phosphoserine By similarity
Modified residuei699 – 6991Phosphoserine By similarity

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

MaxQBiQ61216.
PaxDbiQ61216.
PRIDEiQ61216.

PTM databases

PhosphoSiteiQ61216.

Miscellaneous databases

PMAP-CutDBQ61216.

Expressioni

Gene expression databases

ArrayExpressiQ61216.
BgeeiQ61216.
GenevestigatoriQ61216.

Interactioni

Subunit structurei

Component of the MRN complex composed of two heterodimers RAD50/MRE11A associated with a single NBN. Component of the BASC complex, at least composed of BRCA1, MSH2, MSH6, MLH1, ATM, BLM, RAD50, MRE11A and NBN. Interacts with DCLRE1C/Artemis and DCLRE1B/Apollo By similarity. Interacts with ATF2 By similarity.

Protein-protein interaction databases

BioGridi201486. 4 interactions.
DIPiDIP-46803N.
IntActiQ61216. 4 interactions.

Structurei

3D structure databases

ProteinModelPortaliQ61216.
SMRiQ61216. Positions 8-400.

Family & Domainsi

Sequence similaritiesi

Belongs to the MRE11/RAD32 family.

Phylogenomic databases

eggNOGiCOG0420.
GeneTreeiENSGT00390000017288.
HOGENOMiHOG000216581.
HOVERGENiHBG052508.
InParanoidiQ61216.
KOiK10865.
OMAiQVTMLRP.
OrthoDBiEOG7VB2F1.
PhylomeDBiQ61216.
TreeFamiTF101105.

Family and domain databases

Gene3Di3.60.21.10. 2 hits.
InterProiIPR004843. Calcineurin-like_PHP_apaH.
IPR003701. DNA_repair_Mre11.
IPR029052. Metallo-depent_PP-like.
IPR007281. Mre11_DNA-bd.
[Graphical view]
PANTHERiPTHR10139. PTHR10139. 1 hit.
PfamiPF00149. Metallophos. 1 hit.
PF04152. Mre11_DNA_bind. 1 hit.
[Graphical view]
PIRSFiPIRSF000882. DSB_repair_MRE11. 1 hit.
SUPFAMiSSF56300. SSF56300. 2 hits.
TIGRFAMsiTIGR00583. mre11. 1 hit.

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q61216-1) [UniParc]FASTAAdd to Basket

Also known as: A

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MSPTDPLDDE DTFKILVATD IHLGFMEKDA VRGNDTFVTF DEILRLALEN    50
EVDFILLGGD LFHENKPSRK TLHSCLELLR KYCMGDRPVQ FEVISDQSVN 100
FGFSKFPWVN YQDGNLNISI PVFSIHGNHD DPTGADALCA LDVLSCAGFV 150
NHFGRSMSVE KVDISPVLLQ KGSTKLALYG LGSIPDERLY RMFVNKKVTM 200
LRPKEDENSW FNLFVIHQNR SKHGNTNFIP EQFLDDFIDL VIWGHEHECK 250
IGPIKNEQQL FYVSQPGSSV VTSLSPGEAV KKHVGLLRIK GRKMNMQKLP 300
LRTVRRFFIE DVVLANHPNL FNPDNPKVTQ AIQSFCLEKI EEMLDSAERE 350
RLGNPQQPGK PLIRLRVDYS GGFEPFNVLR FSQKFVDRVA NPKDVIHFFR 400
HREQKGKTGE EINFGMLITK PASEGATLRV EDLVKQYFQT AEKNVQLSLL 450
TERGMGEAVQ EFVDKEEKDA IEELVKYQLE KTQRFLKERH IDALEDKIDE 500
EVRRFRESRQ RNTNEEDDEV REAMSRARAL RSQSETSTSA FSAEDLSFDT 550
SEQTANDSDD SLSAVPSRGR GRGRGRRGAR GQSSAPRGGS QRGRDTGLEI 600
TTRGRSSKAT SSTSRNMSII DAFRSTRQQP SRNVAPKNYS ETIEVDDSDE 650
DDIFPTNSRA DQRWSGTTSS KRMSQSQTAK GVDFESDEDD DDDPFMSSSC 700
PRRNRR 706
Length:706
Mass (Da):80,223
Last modified:November 1, 1996 - v1
Checksum:i0F12F51902FC179A
GO
Isoform 2 (identifier: Q61216-2) [UniParc]FASTAAdd to Basket

Also known as: B

The sequence of this isoform differs from the canonical sequence as follows:
     340-366: Missing.

Show »
Length:679
Mass (Da):77,094
Checksum:i3ACDE474E0425430
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei340 – 36627Missing in isoform 2.
VSP_003263Add
BLAST

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U58987 mRNA. Translation: AAB04955.1.
U60318 mRNA. Translation: AAB03664.1.
BC065144 mRNA. Translation: AAH65144.1.
CCDSiCCDS22827.1. [Q61216-1]
RefSeqiNP_061206.1. NM_018736.2. [Q61216-1]
XP_006510111.1. XM_006510048.1. [Q61216-1]
XP_006510112.1. XM_006510049.1. [Q61216-2]
XP_006510113.1. XM_006510050.1. [Q61216-2]
UniGeneiMm.149071.

Genome annotation databases

EnsembliENSMUST00000034405; ENSMUSP00000034405; ENSMUSG00000031928. [Q61216-1]
ENSMUST00000115632; ENSMUSP00000111295; ENSMUSG00000031928. [Q61216-2]
GeneIDi17535.
KEGGimmu:17535.
UCSCiuc009ofc.1. mouse. [Q61216-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U58987 mRNA. Translation: AAB04955.1 .
U60318 mRNA. Translation: AAB03664.1 .
BC065144 mRNA. Translation: AAH65144.1 .
CCDSi CCDS22827.1. [Q61216-1 ]
RefSeqi NP_061206.1. NM_018736.2. [Q61216-1 ]
XP_006510111.1. XM_006510048.1. [Q61216-1 ]
XP_006510112.1. XM_006510049.1. [Q61216-2 ]
XP_006510113.1. XM_006510050.1. [Q61216-2 ]
UniGenei Mm.149071.

3D structure databases

ProteinModelPortali Q61216.
SMRi Q61216. Positions 8-400.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 201486. 4 interactions.
DIPi DIP-46803N.
IntActi Q61216. 4 interactions.

PTM databases

PhosphoSitei Q61216.

Proteomic databases

MaxQBi Q61216.
PaxDbi Q61216.
PRIDEi Q61216.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000034405 ; ENSMUSP00000034405 ; ENSMUSG00000031928 . [Q61216-1 ]
ENSMUST00000115632 ; ENSMUSP00000111295 ; ENSMUSG00000031928 . [Q61216-2 ]
GeneIDi 17535.
KEGGi mmu:17535.
UCSCi uc009ofc.1. mouse. [Q61216-1 ]

Organism-specific databases

CTDi 4361.
MGIi MGI:1100512. Mre11a.

Phylogenomic databases

eggNOGi COG0420.
GeneTreei ENSGT00390000017288.
HOGENOMi HOG000216581.
HOVERGENi HBG052508.
InParanoidi Q61216.
KOi K10865.
OMAi QVTMLRP.
OrthoDBi EOG7VB2F1.
PhylomeDBi Q61216.
TreeFami TF101105.

Enzyme and pathway databases

Reactomei REACT_188819. DNA Damage/Telomere Stress Induced Senescence.
REACT_196447. IRF3-mediated induction of type I IFN.

Miscellaneous databases

NextBioi 292160.
PMAP-CutDB Q61216.
PROi Q61216.
SOURCEi Search...

Gene expression databases

ArrayExpressi Q61216.
Bgeei Q61216.
Genevestigatori Q61216.

Family and domain databases

Gene3Di 3.60.21.10. 2 hits.
InterProi IPR004843. Calcineurin-like_PHP_apaH.
IPR003701. DNA_repair_Mre11.
IPR029052. Metallo-depent_PP-like.
IPR007281. Mre11_DNA-bd.
[Graphical view ]
PANTHERi PTHR10139. PTHR10139. 1 hit.
Pfami PF00149. Metallophos. 1 hit.
PF04152. Mre11_DNA_bind. 1 hit.
[Graphical view ]
PIRSFi PIRSF000882. DSB_repair_MRE11. 1 hit.
SUPFAMi SSF56300. SSF56300. 2 hits.
TIGRFAMsi TIGR00583. mre11. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Oshiumi H., Shinohara A., Ogawa H.
    Submitted (MAY-1996) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2).
    Strain: CD-1.
    Tissue: Testis.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Strain: C57BL/6.
    Tissue: Retina.
  3. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-2, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Liver.

Entry informationi

Entry nameiMRE11_MOUSE
AccessioniPrimary (citable) accession number: Q61216
Secondary accession number(s): Q62430
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 26, 2001
Last sequence update: November 1, 1996
Last modified: September 3, 2014
This is version 115 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi