Reviewed,
UniProtKB/Swiss-Prot Q61216 (MRE11_MOUSE)
Last modified
February 9, 2010.
Version 78.
History...
Clusters with 100%,
90%,
50% identity |
Documents (2) |
Third-party data |
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Names and origin
| Protein names | Recommended name: Double-strand break repair protein MRE11A Short name=MmMRE11A Alternative name(s): Meiotic recombination 11 homolog A Short name=MRE11 homolog A Meiotic recombination 11 homolog 1 Short name=MRE11 homolog 1 | ||||
| Gene names |
| ||||
| Organism | Mus musculus (Mouse) | ||||
| Taxonomic identifier | 10090 [NCBI] | ||||
| Taxonomic lineage | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus |
Protein attributes
| Sequence length | 706 AA. |
| Sequence status | Complete. |
| Protein existence | Evidence at transcript level. |
General annotation (Comments)
| Function | Component of the MRN complex, which plays a central role in double-strand break (DSB) repair, DNA recombination, maintenance of telomere integrity and meiosis. The complex possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity, which are provided by MRE11A. RAD50 may be required to bind DNA ends and hold them in close proximity. This could facilitate searches for short or long regions of sequence homology in the recombining DNA templates, and may also stimulate the activity of DNA ligases and/or restrict the nuclease activity of MRE11A to prevent nucleolytic degradation past a given point. The complex may also be required for DNA damage signaling via activation of the ATM kinase. In telomeres the MRN complex may modulate t-loop formation By similarity. |
| Cofactor | Manganese By similarity. |
| Subunit structure | Component of the MRN complex composed of two heterodimers RAD50/MRE11A associated with a single NBN. Component of the BASC complex, at least composed of BRCA1, MSH2, MSH6, MLH1, ATM, BLM, RAD50, MRE11A and NBN. Interacts with DCLRE1C/Artemis By similarity. |
| Subcellular location | Nucleus By similarity. Note: Localizes to discrete nuclear foci after treatment with genotoxic agents By similarity. |
| Post-translational modification | Phosphorylated upon DNA damage, probably by ATM or ATR By similarity. |
| Sequence similarities | Belongs to the MRE11/RAD32 family. |
Ontologies
| Keywords | |
|---|---|
| Biological process | DNA damage DNA repair Meiosis |
| Cellular component | Nucleus |
| Coding sequence diversity | Alternative splicing |
| Ligand | Manganese |
| Molecular function | Endonuclease Exonuclease Hydrolase Nuclease |
| PTM | Phosphoprotein |
| Gene Ontology (GO) | |
| Biological process | double-strand break repair Inferred from electronic annotation. Source: InterPro meiosisInferred from electronic annotation. Source: UniProtKB-KW |
| Molecular function | endonuclease activity Inferred from electronic annotation. Source: UniProtKB-KW exonuclease activityInferred from electronic annotation. Source: UniProtKB-KW manganese ion bindingInferred from electronic annotation. Source: UniProtKB-KW |
| Complete GO annotation... | |
Alternative products
| This entry describes 2 isoforms produced by alternative splicing. [Align] [Select] | ||||||
| Isoform 1 (identifier: Q61216-1) Also known as: A; This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. | ||||||
| Isoform 2 (identifier: Q61216-2) Also known as: B; The sequence of this isoform differs from the canonical sequence as follows: 340-366: Missing. |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 706 | 706 | Double-strand break repair protein MRE11A | PRO_0000138674 | |||||
Sites | |||||||||
| Active site | 129 | 1 | Proton donor By similarity | ||||||
Amino acid modifications | |||||||||
| Modified residue | 74 | 1 | Phosphoserine By similarity | ||||||
| Modified residue | 648 | 1 | Phosphoserine By similarity | ||||||
| Modified residue | 676 | 1 | Phosphoserine By similarity | ||||||
| Modified residue | 686 | 1 | Phosphoserine By similarity | ||||||
Natural variations | |||||||||
| Alternative sequence | 340 – 366 | 27 | Missing in isoform 2. | VSP_003263 | |||||
Sequences
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References
| « Hide 'large scale' references | |
| [1] | Oshiumi H., Shinohara A., Ogawa H. Submitted (MAY-1996) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2). Strain: CD-1. Tissue: Testis. |
| [2] | "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1). Strain: C57BL/6. Tissue: Retina. |
| + | Additional computationally mapped references. |
Cross-references
Sequence databases | |
|---|---|
| EMBL GenBank DDBJ | U58987 mRNA. Translation: AAB04955.1. U60318 mRNA. Translation: AAB03664.1. BC065144 mRNA. Translation: AAH65144.1. |
| IPI | IPI00118853. IPI00283379. |
| RefSeq | NP_061206.1. |
| UniGene | Mm.149071 |
3D structure databases | |
| SMR | Q61216. Positions 13-295. |
| ModBase | Search... |
Protein-protein interaction databases | |
| IntAct | Q61216. 3 interactions. |
| STRING | Q61216. |
PTM databases | |
| PhosphoSite | Q61216. |
Proteomic databases | |
| PRIDE | Q61216. |
Genome annotation databases | |
| Ensembl | ENSMUST00000034405; ENSMUSP00000034405; ENSMUSG00000031928; Mus musculus. [Genome view] ENSMUST00000115632; ENSMUSP00000111295; ENSMUSG00000031928; Mus musculus. [Genome view] |
| GeneID | 17535. |
| KEGG | mmu:17535. |
| UCSC | uc009ofc.1. mouse. uc009ofd.1. mouse. |
Organism-specific databases | |
| CTD | 17535. |
| MGI | MGI:1100512. Mre11a. |
Phylogenomic databases | |
| HOGENOM | HBG596413. |
| HOVERGEN | Q61216. |
| InParanoid | Q61216. |
| OMA | GEAVKKH. |
| PhylomeDB | Q61216. |
Gene expression databases | |
| ArrayExpress | Q61216. |
| Bgee | Q61216. |
| Genevestigator | Q61216. |
| GermOnline | ENSMUSG00000031928. Mus musculus. |
Family and domain databases | |
| InterPro | IPR003701. DNA_repair. IPR004843. M-pesterase. IPR007281. Mre11_DNA_bd. [Graphical view] |
| PANTHER | PTHR10139. DNA_repair. 1 hit. |
| Pfam | PF00149. Metallophos. 1 hit. PF04152. Mre11_DNA_bind. 1 hit. [Graphical view] |
| PIRSF | PIRSF000882. DSB_repair_MRE11. 1 hit. |
| TIGRFAMs | TIGR00583. mre11. 1 hit. |
| ProtoNet | Search... |
Other Resources | |
| NextBio | 292160. |
| PMAP-CutDB | Q61216. |
| SOURCE | Search... |
Entry information
| Entry name | MRE11_MOUSE | ||||||||
| Accession | Primary (citable) accession number: Q61216 Secondary accession number(s): Q62430 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | HPI (Human Proteome Initiative) | ||||||||
Relevant documents
| MGD cross-references Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot |
| SIMILARITY comments Index of protein domains and families |

Clusters with


