Reviewed, UniProtKB/Swiss-Prot Q61212 (NPY6R_MOUSE)

Names and origin

Protein names

Recommended name:
    Neuropeptide Y receptor type 6
      Short name=NPY6-R
Alternative name(s):
    Pancreatic polypeptide receptor 2
      Short name=PP2

Gene names

Name:	Npy6r
Synonyms:	Npy5r, Ppyr2, Y2b

Organism

Mus musculus (Mouse)

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus

Protein attributes

Sequence length	371 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Function	Receptor for neuropeptide Y and peptide YY. The rank order of affinity of this receptor for pancreatic polypeptides is NPY = PYY >= NPY (2-36) = [Leu-31, Pro-34] NPY > NPY (13-36) > PP. The activity of this receptor is mediated by G proteins that inhibits adenylate cyclase activity.
Subcellular location	Cell membrane; Multi-pass membrane protein.
Tissue specificity	Kidney and discrete regions of the hypothalamus including the suprachiasmatic nucleus, anterior hypothalamus, bed nucleus stria terminalis, and the ventromedial nucleus.
Developmental stage	Expressed in embryo at 7 dpc. Ref.2
Sequence similarities	Belongs to the G-protein coupled receptor 1 family.
Caution	Was originally called NPY5-R.

Ontologies

Keywords
Cellular component	Cell membrane Membrane
Domain	Transmembrane
Molecular function	G-protein coupled receptor Receptor Transducer
PTM	Disulfide bond Glycoprotein Lipoprotein Palmitate Phosphoprotein
Gene Ontology (GO)
Biological process	G-protein coupled receptor protein signaling pathway Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW plasma membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	peptide YY receptor activity Inferred from direct assay. Source: MGI
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 371	371	Neuropeptide Y receptor type 6		PRO_0000069943
Regions
	Topological domain	1 – 31	31	Extracellular Potential
	Transmembrane	32 – 52	21	1 Potential
	Topological domain	53 – 82	30	Cytoplasmic Potential
	Transmembrane	83 – 103	21	2 Potential
	Topological domain	104 – 111	8	Extracellular Potential
	Transmembrane	112 – 132	21	3 Potential
	Topological domain	133 – 150	18	Cytoplasmic Potential
	Transmembrane	151 – 171	21	4 Potential
	Topological domain	172 – 206	35	Extracellular Potential
	Transmembrane	207 – 227	21	5 Potential
	Topological domain	228 – 263	36	Cytoplasmic Potential
	Transmembrane	264 – 284	21	6 Potential
	Topological domain	285 – 297	13	Extracellular Potential
	Transmembrane	298 – 318	21	7 Potential
	Topological domain	319 – 371	53	Cytoplasmic Potential
Amino acid modifications
	Lipidation	336	1	S-palmitoyl cysteine Potential
	Glycosylation	11	1	N-linked (GlcNAc...) Potential
	Glycosylation	18	1	N-linked (GlcNAc...) Potential
	Glycosylation	182	1	N-linked (GlcNAc...) Potential
	Disulfide bond	109 ↔ 196		By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q61212-1 [UniParc]. Last modified November 1, 1997. Version 1. Checksum: E4AABB987CEB74B7	FASTA	371	42,714
	10 20 30 40 50 60 MEVLTNQPTP NKTSGKSNNS AFFYFESCQP PFLAILLLLI AYTVILIMGI FGNLSLIIII 70 80 90 100 110 120 FKKQREAQNV TNILIANLSL SDILVCVMCI PFTVIYTLMD HWVFGNTMCK LTSYVQSVSV 130 140 150 160 170 180 SVSIFSLVLI AIERYQLIVN PRGWKPRVAH AYWGIILIWL ISLTLSIPLF LSYHLTNEPF 190 200 210 220 230 240 HNLSLPTDIY THQVACVEIW PSKLNQLLFS TSLFMLQYFV PLGFILICYL KIVLCLRKRT 250 260 270 280 290 300 RQVDRRKENK SRLNENKRVN VMLISIVVTF GACWLPLNIF NVIFDWYHEM LMSCHHDLVF 310 320 330 340 350 360 VVCHLIAMVS TCINPLFYGF LNKNFQKDLM MLIHHCWCGE PQESYENIAM STMHTDESKG 370 SLKLAHIPTG I

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Cloning and expression of a novel neuropeptide Y receptor." Weinberg D.H., Sirinathsinghji D.J.S., Tan C.P., Shiao L.-L., Morin N., Rigby M.R., Heavens R.H., Rapoport D.R., Bayne M.L., Cascieri M.A., Strader C.D., Linemeyer D.L., Macneil D.J. J. Biol. Chem. 271:16435-16438(1996) [PubMed: 8663568] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: 129.
[2]	"Molecular characterization of a second mouse pancreatic polypeptide receptor and its inactivated human homologue." Gregor P., Feng Y., Decarr L.B., Cornfield L.J., McCaleb M.L. J. Biol. Chem. 271:27776-27781(1996) [PubMed: 8910373] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], DEVELOPMENTAL STAGE. Strain: 129/Sv.
[3]	"The transcriptional landscape of the mammalian genome." Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y. Science 309:1559-1563(2005) [PubMed: 16141072] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: C57BL/6J. Tissue: Ovary.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBLGenBankDDBJ	U58367 Genomic DNA. Translation: AAB18624.1. U59430 Genomic DNA. Translation: AAB19188.1. AK030279 mRNA. Translation: BAC26875.1.
IPI	IPI00118847.
RefSeq	NP_035065.1.
UniGene	Mm.57234
3D structure databases
ModBase	Search...
Protein family/group databases
GPCRDB	Search...
Genome annotation databases
Ensembl	ENSMUSG00000038071. Mus musculus. [Contig view]
GeneID	18169.
KEGG	mmu:18169.
Organism-specific databases
MGI	MGI:1098590. Npy6r.
Phylogenomic databases
HOGENOM	Q61212.
HOVERGEN	Q61212.
OMA	Q61212. LESSCAF.
Gene expression databases
ArrayExpress	Q61212.
Bgee	Q61212.
CleanEx	MM_NPY5R. MM_NPY6R.
GermOnline	ENSMUSG00000038071. Mus musculus.
Family and domain databases
InterPro	IPR000276. 7TM_GPCR_Rhodpsn. IPR017452. GPCR_Rhodpsn_supfam. IPR000986. NeuroY6_rcpt. IPR000611. NPY_rcpt. [Graphical view]
Pfam	PF00001. 7tm_1. 1 hit. [Graphical view]
PRINTS	PR00237. GPCRRHODOPSN. PR01017. NRPEPTIDEY6R. PR01012. NRPEPTIDEYR.
PROSITE	PS00237. G_PROTEIN_RECEP_F1_1. 1 hit. PS50262. G_PROTEIN_RECEP_F1_2. 1 hit. [Graphical view]
ProtoNet	Search...
Other Resources
NextBio	293462.
SOURCE	Search...

Entry information

Entry name

NPY6R_MOUSE

Accession

Primary (citable) accession number: Q61212

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1997
Last sequence update:	November 1, 1997
Last modified:	June 16, 2009
This is version 70 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)