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Q61207 (SAP_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 131. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Sulfated glycoprotein 1

Short name=SGP-1
Alternative name(s):
Prosaposin
Gene names
Name:Psap
Synonyms:Sgp1
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length557 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Subcellular location

Secretedextracellular space.

Sequence similarities

Contains 2 saposin A-type domains.

Contains 4 saposin B-type domains.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 1616 By similarity
Chain17 – 557541Sulfated glycoprotein 1
PRO_0000031626

Regions

Domain18 – 5841Saposin A-type 1
Domain59 – 14284Saposin B-type 1
Domain193 – 27785Saposin B-type 2
Domain313 – 39482Saposin B-type 3
Domain438 – 51982Saposin B-type 4
Domain521 – 55737Saposin A-type 2

Amino acid modifications

Glycosylation801N-linked (GlcNAc...) Ref.7
Glycosylation2141N-linked (GlcNAc...) Potential
Glycosylation3341N-linked (GlcNAc...) Ref.7
Glycosylation4591N-linked (GlcNAc...) Potential
Disulfide bond63 ↔ 138 By similarity
Disulfide bond66 ↔ 132 By similarity
Disulfide bond94 ↔ 106 By similarity
Disulfide bond197 ↔ 273 By similarity
Disulfide bond200 ↔ 267 By similarity
Disulfide bond229 ↔ 240 By similarity
Disulfide bond317 ↔ 390 By similarity
Disulfide bond320 ↔ 384 By similarity
Disulfide bond348 ↔ 359 By similarity
Disulfide bond442 ↔ 515 By similarity
Disulfide bond445 ↔ 509 By similarity
Disulfide bond473 ↔ 484 By similarity

Experimental info

Sequence conflict831Q → E in AAB31059. Ref.2
Sequence conflict1581I → V in AAA92567. Ref.4
Sequence conflict1601Missing in AAB31059. Ref.2
Sequence conflict171 – 1722MS → SA in AAA92567. Ref.4
Sequence conflict2441V → L in AAB31059. Ref.2
Sequence conflict2541M → I in AAA92567. Ref.4
Sequence conflict2551L → W in AAB31059. Ref.2
Sequence conflict260 – 2623Missing Ref.4
Sequence conflict3071N → D in AAB31059. Ref.2
Sequence conflict3221F → L in AAB31059. Ref.2
Sequence conflict349 – 3502AL → GV in AAB22175. Ref.1
Sequence conflict3671G → D in AAA92567. Ref.4
Sequence conflict3701L → Q in AAB31059. Ref.2
Sequence conflict3731I → D in AAA92567. Ref.4
Sequence conflict3911A → T Ref.4
Sequence conflict3931R → L Ref.4
Sequence conflict4061A → R Ref.2
Sequence conflict4061A → R Ref.4
Sequence conflict4301P → R in AAB31059. Ref.2
Sequence conflict4451C → F in AAA92567. Ref.4
Sequence conflict4481L → P in AAB02695. Ref.5

Sequences

Sequence LengthMass (Da)Tools
Q61207 [UniParc].

Last modified December 15, 1998. Version 2.
Checksum: 134593E20499E35E

FASTA55761,422
        10         20         30         40         50         60 
MYALALFASL LATALTSPVQ DPKTCSGGSA VLCRDVKTAV DCGAVKHCQQ MVWSKPTAKS 

        70         80         90        100        110        120 
LPCDICKTVV TEAGNLLKDN ATQEEILHYL EKTCEWIHDS SLSASCKEVV DSYLPVILDM 

       130        140        150        160        170        180 
IKGEMSNPGE VCSALNLCQS LQEYLAEQNQ KQLESNKIPE VDMARVVAPF MSNIPLLLYP 

       190        200        210        220        230        240 
QDHPRSQPQP KANEDVCQDC MKLVSDVQTA VKTNSSFIQG FVDHVKEDCD RLGPGVSDIC 

       250        260        270        280        290        300 
KNYVDQYSEV CVQMLMHMQD QQPKEICVLA GFCNEVKRVP MKTLVPATET IKNILPALEM 

       310        320        330        340        350        360 
MDPYEQNLVQ AHNVILCQTC QFVMNKFSEL IVNNATEELL VKGLSNACAL LPDPARTKCQ 

       370        380        390        400        410        420 
EVVGTFGPSL LDIFIHEVNP SSLCGVIGLC AARPELVEAL EQPAPAIVSA LLKEPTPPKQ 

       430        440        450        460        470        480 
PAQPKQSALP AHVPPQKNGG FCEVCKKLVL YLEHNLEKNS TKEEILAALE KGCSFLPDPY 

       490        500        510        520        530        540 
QKQCDDFVAE YEPLLLEILV EVMDPGFVCS KIGVCPSAYK LLLGTEKCVW GPSYWCQNME 

       550 
TAARCNAVDH CKRHVWN 

« Hide

References

« Hide 'large scale' references
[1]"The primary structure of mouse saposin."
Tsuda M., Sakiyama T., Endo H., Kitagawa T.
Biochem. Biophys. Res. Commun. 184:1266-1272(1992) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Liver.
[2]"Murine prosaposin: expression in the reproductive system of a gene implicated in human genetic diseases."
Sprecher-Levy H., Orr-Urtreger A., Lonai P., Horowitz M.
Cell. Mol. Biol. 39:287-299(1993) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE.
[3]Erratum
Sprecher-Levy H., Orr-Urtreger A., Lonai P., Horowitz M.
Cell. Mol. Biol. 40:233-233(1994) [PubMed] [Europe PMC] [Abstract]
[4]"Expression of SGP-1 mRNA in preimplantation mouse embryos."
Cao Q.P., Crain W.R.
Dev. Genet. 17:263-271(1995) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[5]Zhao Q.Q., Hay N.N., Morales C.R.
Submitted (MAY-1996) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE.
Strain: BALB/c.
Tissue: Liver.
[6]Lubec G., Kang S.U.
Submitted (APR-2007) to UniProtKB
Cited for: PROTEIN SEQUENCE OF 68-78 AND 463-482, IDENTIFICATION BY MASS SPECTROMETRY.
Strain: C57BL/6.
Tissue: Brain.
[7]"Mass-spectrometric identification and relative quantification of N-linked cell surface glycoproteins."
Wollscheid B., Bausch-Fluck D., Henderson C., O'Brien R., Bibel M., Schiess R., Aebersold R., Watts J.D.
Nat. Biotechnol. 27:378-386(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-80 AND ASN-334.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
S36200 mRNA. Translation: AAB22175.1.
S71616 mRNA. Translation: AAB31059.1.
U27340 mRNA. Translation: AAA92567.1.
U57999 Genomic DNA. Translation: AAB02695.1.
CCDSCCDS35911.1.
PIRJH0604.
RefSeqNP_001139592.1. NM_001146120.1.
NP_001139593.1. NM_001146121.1.
NP_001139594.1. NM_001146122.1.
NP_001139595.1. NM_001146123.1.
NP_001139596.1. NM_001146124.1.
NP_035309.3. NM_011179.3.
UniGeneMm.277498.

3D structure databases

ProteinModelPortalQ61207.
SMRQ61207. Positions 60-139, 195-274, 315-391, 439-517.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

IntActQ61207. 5 interactions.
MINTMINT-1734080.

PTM databases

PhosphoSiteQ61207.

Proteomic databases

MaxQBQ61207.
PaxDbQ61207.
PRIDEQ61207.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000179238; ENSMUSP00000137476; ENSMUSG00000004207.
GeneID19156.
KEGGmmu:19156.
UCSCuc007fen.2. mouse.

Organism-specific databases

CTD5660.
MGIMGI:97783. Psap.

Phylogenomic databases

eggNOGNOG269151.
GeneTreeENSGT00530000063434.
HOGENOMHOG000049216.
HOVERGENHBG002617.
InParanoidQ61207.
KOK12382.
PhylomeDBQ61207.

Gene expression databases

ArrayExpressQ61207.
BgeeQ61207.
CleanExMM_PSAP.
GenevestigatorQ61207.

Family and domain databases

Gene3D1.10.225.10. 4 hits.
InterProIPR003119. SapA.
IPR007856. SapB_1.
IPR008138. SapB_2.
IPR008373. Saposin.
IPR011001. Saposin-like.
IPR021165. Saposin_chordata.
IPR008139. SaposinB.
[Graphical view]
PfamPF02199. SapA. 2 hits.
PF05184. SapB_1. 4 hits.
PF03489. SapB_2. 4 hits.
[Graphical view]
PIRSFPIRSF002431. Saposin. 1 hit.
PRINTSPR01797. SAPOSIN.
SMARTSM00162. SAPA. 2 hits.
SM00741. SapB. 4 hits.
[Graphical view]
SUPFAMSSF47862. SSF47862. 3 hits.
PROSITEPS51110. SAP_A. 2 hits.
PS50015. SAP_B. 4 hits.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSPSAP. mouse.
NextBio295806.
PROQ61207.
SOURCESearch...

Entry information

Entry nameSAP_MOUSE
AccessionPrimary (citable) accession number: Q61207
Secondary accession number(s): Q60861, Q64006, Q64219
Entry history
Integrated into UniProtKB/Swiss-Prot: December 15, 1998
Last sequence update: December 15, 1998
Last modified: July 9, 2014
This is version 131 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot