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Q61207

- SAP_MOUSE

UniProt

Q61207 - SAP_MOUSE

Protein

Sulfated glycoprotein 1

Gene

Psap

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 133 (01 Oct 2014)
      Sequence version 2 (15 Dec 1998)
      Previous versions | rss
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    Functioni

    GO - Biological processi

    1. cellular response to organic substance Source: MGI
    2. developmental growth Source: MGI
    3. epithelial cell differentiation involved in prostate gland development Source: MGI
    4. prostate gland growth Source: MGI
    5. regulation of lipid metabolic process Source: MGI
    6. regulation of MAPK cascade Source: MGI
    7. sphingolipid metabolic process Source: InterPro

    Enzyme and pathway databases

    ReactomeiREACT_199008. Glycosphingolipid metabolism.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Sulfated glycoprotein 1
    Short name:
    SGP-1
    Alternative name(s):
    Prosaposin
    Gene namesi
    Name:Psap
    Synonyms:Sgp1
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 10

    Organism-specific databases

    MGIiMGI:97783. Psap.

    Subcellular locationi

    GO - Cellular componenti

    1. extracellular space Source: UniProtKB-SubCell
    2. Golgi apparatus Source: Ensembl
    3. lysosome Source: InterPro
    4. mitochondrion Source: MGI

    Keywords - Cellular componenti

    Secreted

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 1616By similarityAdd
    BLAST
    Chaini17 – 557541Sulfated glycoprotein 1PRO_0000031626Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi63 ↔ 138PROSITE-ProRule annotation
    Disulfide bondi66 ↔ 132PROSITE-ProRule annotation
    Glycosylationi80 – 801N-linked (GlcNAc...)1 PublicationPROSITE-ProRule annotation
    Disulfide bondi94 ↔ 106PROSITE-ProRule annotation
    Disulfide bondi197 ↔ 273PROSITE-ProRule annotation
    Disulfide bondi200 ↔ 267PROSITE-ProRule annotation
    Glycosylationi214 – 2141N-linked (GlcNAc...)PROSITE-ProRule annotation
    Disulfide bondi229 ↔ 240PROSITE-ProRule annotation
    Disulfide bondi317 ↔ 390PROSITE-ProRule annotation
    Disulfide bondi320 ↔ 384PROSITE-ProRule annotation
    Glycosylationi334 – 3341N-linked (GlcNAc...)1 PublicationPROSITE-ProRule annotation
    Disulfide bondi348 ↔ 359PROSITE-ProRule annotation
    Disulfide bondi442 ↔ 515PROSITE-ProRule annotation
    Disulfide bondi445 ↔ 509PROSITE-ProRule annotation
    Glycosylationi459 – 4591N-linked (GlcNAc...)PROSITE-ProRule annotation
    Disulfide bondi473 ↔ 484PROSITE-ProRule annotation

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    MaxQBiQ61207.
    PaxDbiQ61207.
    PRIDEiQ61207.

    PTM databases

    PhosphoSiteiQ61207.

    Expressioni

    Gene expression databases

    ArrayExpressiQ61207.
    BgeeiQ61207.
    CleanExiMM_PSAP.
    GenevestigatoriQ61207.

    Interactioni

    Protein-protein interaction databases

    IntActiQ61207. 5 interactions.
    MINTiMINT-1734080.

    Structurei

    3D structure databases

    ProteinModelPortaliQ61207.
    SMRiQ61207. Positions 60-139, 195-274, 315-391, 439-517.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini18 – 5841Saposin A-type 1PROSITE-ProRule annotationAdd
    BLAST
    Domaini59 – 14284Saposin B-type 1PROSITE-ProRule annotationAdd
    BLAST
    Domaini193 – 27785Saposin B-type 2PROSITE-ProRule annotationAdd
    BLAST
    Domaini313 – 39482Saposin B-type 3PROSITE-ProRule annotationAdd
    BLAST
    Domaini438 – 51982Saposin B-type 4PROSITE-ProRule annotationAdd
    BLAST
    Domaini521 – 55737Saposin A-type 2PROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Contains 2 saposin A-type domains.PROSITE-ProRule annotation
    Contains 4 saposin B-type domains.PROSITE-ProRule annotation

    Keywords - Domaini

    Repeat, Signal

    Phylogenomic databases

    eggNOGiNOG269151.
    GeneTreeiENSGT00530000063434.
    HOGENOMiHOG000049216.
    HOVERGENiHBG002617.
    InParanoidiQ61207.
    KOiK12382.
    PhylomeDBiQ61207.

    Family and domain databases

    Gene3Di1.10.225.10. 4 hits.
    InterProiIPR003119. SapA.
    IPR007856. SapB_1.
    IPR008138. SapB_2.
    IPR008373. Saposin.
    IPR011001. Saposin-like.
    IPR021165. Saposin_chordata.
    IPR008139. SaposinB.
    [Graphical view]
    PfamiPF02199. SapA. 2 hits.
    PF05184. SapB_1. 4 hits.
    PF03489. SapB_2. 4 hits.
    [Graphical view]
    PIRSFiPIRSF002431. Saposin. 1 hit.
    PRINTSiPR01797. SAPOSIN.
    SMARTiSM00162. SAPA. 2 hits.
    SM00741. SapB. 4 hits.
    [Graphical view]
    SUPFAMiSSF47862. SSF47862. 3 hits.
    PROSITEiPS51110. SAP_A. 2 hits.
    PS50015. SAP_B. 4 hits.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q61207-1 [UniParc]FASTAAdd to Basket

    « Hide

    MYALALFASL LATALTSPVQ DPKTCSGGSA VLCRDVKTAV DCGAVKHCQQ    50
    MVWSKPTAKS LPCDICKTVV TEAGNLLKDN ATQEEILHYL EKTCEWIHDS 100
    SLSASCKEVV DSYLPVILDM IKGEMSNPGE VCSALNLCQS LQEYLAEQNQ 150
    KQLESNKIPE VDMARVVAPF MSNIPLLLYP QDHPRSQPQP KANEDVCQDC 200
    MKLVSDVQTA VKTNSSFIQG FVDHVKEDCD RLGPGVSDIC KNYVDQYSEV 250
    CVQMLMHMQD QQPKEICVLA GFCNEVKRVP MKTLVPATET IKNILPALEM 300
    MDPYEQNLVQ AHNVILCQTC QFVMNKFSEL IVNNATEELL VKGLSNACAL 350
    LPDPARTKCQ EVVGTFGPSL LDIFIHEVNP SSLCGVIGLC AARPELVEAL 400
    EQPAPAIVSA LLKEPTPPKQ PAQPKQSALP AHVPPQKNGG FCEVCKKLVL 450
    YLEHNLEKNS TKEEILAALE KGCSFLPDPY QKQCDDFVAE YEPLLLEILV 500
    EVMDPGFVCS KIGVCPSAYK LLLGTEKCVW GPSYWCQNME TAARCNAVDH 550
    CKRHVWN 557
    Length:557
    Mass (Da):61,422
    Last modified:December 15, 1998 - v2
    Checksum:i134593E20499E35E
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti83 – 831Q → E in AAB31059. (PubMed:8334382)Curated
    Sequence conflicti158 – 1581I → V in AAA92567. (PubMed:8565332)Curated
    Sequence conflicti160 – 1601Missing in AAB31059. (PubMed:8334382)Curated
    Sequence conflicti171 – 1722MS → SA in AAA92567. (PubMed:8565332)Curated
    Sequence conflicti244 – 2441V → L in AAB31059. (PubMed:8334382)Curated
    Sequence conflicti254 – 2541M → I in AAA92567. (PubMed:8565332)Curated
    Sequence conflicti255 – 2551L → W in AAB31059. (PubMed:8334382)Curated
    Sequence conflicti260 – 2623Missing(PubMed:8565332)Curated
    Sequence conflicti307 – 3071N → D in AAB31059. (PubMed:8334382)Curated
    Sequence conflicti322 – 3221F → L in AAB31059. (PubMed:8334382)Curated
    Sequence conflicti349 – 3502AL → GV in AAB22175. (PubMed:1590788)Curated
    Sequence conflicti367 – 3671G → D in AAA92567. (PubMed:8565332)Curated
    Sequence conflicti370 – 3701L → Q in AAB31059. (PubMed:8334382)Curated
    Sequence conflicti373 – 3731I → D in AAA92567. (PubMed:8565332)Curated
    Sequence conflicti391 – 3911A → T(PubMed:8565332)Curated
    Sequence conflicti393 – 3931R → L(PubMed:8565332)Curated
    Sequence conflicti406 – 4061A → R(PubMed:8334382)Curated
    Sequence conflicti406 – 4061A → R(PubMed:8565332)Curated
    Sequence conflicti430 – 4301P → R in AAB31059. (PubMed:8334382)Curated
    Sequence conflicti445 – 4451C → F in AAA92567. (PubMed:8565332)Curated
    Sequence conflicti448 – 4481L → P in AAB02695. 1 PublicationCurated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    S36200 mRNA. Translation: AAB22175.1.
    S71616 mRNA. Translation: AAB31059.1.
    U27340 mRNA. Translation: AAA92567.1.
    U57999 Genomic DNA. Translation: AAB02695.1.
    CCDSiCCDS35911.1.
    PIRiJH0604.
    RefSeqiNP_001139592.1. NM_001146120.1.
    NP_001139593.1. NM_001146121.1.
    NP_001139594.1. NM_001146122.1.
    NP_001139595.1. NM_001146123.1.
    NP_001139596.1. NM_001146124.1.
    NP_035309.3. NM_011179.3.
    UniGeneiMm.277498.

    Genome annotation databases

    EnsembliENSMUST00000179238; ENSMUSP00000137476; ENSMUSG00000004207.
    GeneIDi19156.
    KEGGimmu:19156.
    UCSCiuc007fen.2. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    S36200 mRNA. Translation: AAB22175.1 .
    S71616 mRNA. Translation: AAB31059.1 .
    U27340 mRNA. Translation: AAA92567.1 .
    U57999 Genomic DNA. Translation: AAB02695.1 .
    CCDSi CCDS35911.1.
    PIRi JH0604.
    RefSeqi NP_001139592.1. NM_001146120.1.
    NP_001139593.1. NM_001146121.1.
    NP_001139594.1. NM_001146122.1.
    NP_001139595.1. NM_001146123.1.
    NP_001139596.1. NM_001146124.1.
    NP_035309.3. NM_011179.3.
    UniGenei Mm.277498.

    3D structure databases

    ProteinModelPortali Q61207.
    SMRi Q61207. Positions 60-139, 195-274, 315-391, 439-517.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    IntActi Q61207. 5 interactions.
    MINTi MINT-1734080.

    PTM databases

    PhosphoSitei Q61207.

    Proteomic databases

    MaxQBi Q61207.
    PaxDbi Q61207.
    PRIDEi Q61207.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000179238 ; ENSMUSP00000137476 ; ENSMUSG00000004207 .
    GeneIDi 19156.
    KEGGi mmu:19156.
    UCSCi uc007fen.2. mouse.

    Organism-specific databases

    CTDi 5660.
    MGIi MGI:97783. Psap.

    Phylogenomic databases

    eggNOGi NOG269151.
    GeneTreei ENSGT00530000063434.
    HOGENOMi HOG000049216.
    HOVERGENi HBG002617.
    InParanoidi Q61207.
    KOi K12382.
    PhylomeDBi Q61207.

    Enzyme and pathway databases

    Reactomei REACT_199008. Glycosphingolipid metabolism.

    Miscellaneous databases

    ChiTaRSi PSAP. mouse.
    NextBioi 295806.
    PROi Q61207.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q61207.
    Bgeei Q61207.
    CleanExi MM_PSAP.
    Genevestigatori Q61207.

    Family and domain databases

    Gene3Di 1.10.225.10. 4 hits.
    InterProi IPR003119. SapA.
    IPR007856. SapB_1.
    IPR008138. SapB_2.
    IPR008373. Saposin.
    IPR011001. Saposin-like.
    IPR021165. Saposin_chordata.
    IPR008139. SaposinB.
    [Graphical view ]
    Pfami PF02199. SapA. 2 hits.
    PF05184. SapB_1. 4 hits.
    PF03489. SapB_2. 4 hits.
    [Graphical view ]
    PIRSFi PIRSF002431. Saposin. 1 hit.
    PRINTSi PR01797. SAPOSIN.
    SMARTi SM00162. SAPA. 2 hits.
    SM00741. SapB. 4 hits.
    [Graphical view ]
    SUPFAMi SSF47862. SSF47862. 3 hits.
    PROSITEi PS51110. SAP_A. 2 hits.
    PS50015. SAP_B. 4 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Liver.
    2. "Murine prosaposin: expression in the reproductive system of a gene implicated in human genetic diseases."
      Sprecher-Levy H., Orr-Urtreger A., Lonai P., Horowitz M.
      Cell. Mol. Biol. 39:287-299(1993) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE.
    3. Erratum
      Sprecher-Levy H., Orr-Urtreger A., Lonai P., Horowitz M.
      Cell. Mol. Biol. 40:233-233(1994) [PubMed] [Europe PMC] [Abstract]
    4. "Expression of SGP-1 mRNA in preimplantation mouse embryos."
      Cao Q.P., Crain W.R.
      Dev. Genet. 17:263-271(1995) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    5. Zhao Q.Q., Hay N.N., Morales C.R.
      Submitted (MAY-1996) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: BALB/c.
      Tissue: Liver.
    6. Lubec G., Kang S.U.
      Submitted (APR-2007) to UniProtKB
      Cited for: PROTEIN SEQUENCE OF 68-78 AND 463-482, IDENTIFICATION BY MASS SPECTROMETRY.
      Strain: C57BL/6.
      Tissue: Brain.
    7. "Mass-spectrometric identification and relative quantification of N-linked cell surface glycoproteins."
      Wollscheid B., Bausch-Fluck D., Henderson C., O'Brien R., Bibel M., Schiess R., Aebersold R., Watts J.D.
      Nat. Biotechnol. 27:378-386(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-80 AND ASN-334.

    Entry informationi

    Entry nameiSAP_MOUSE
    AccessioniPrimary (citable) accession number: Q61207
    Secondary accession number(s): Q60861, Q64006, Q64219
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 15, 1998
    Last sequence update: December 15, 1998
    Last modified: October 1, 2014
    This is version 133 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3