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Q61207

- SAP_MOUSE

UniProt

Q61207 - SAP_MOUSE

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Protein

Sulfated glycoprotein 1

Gene
Psap, Sgp1
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

GO - Biological processi

  1. cellular response to organic substance Source: MGI
  2. developmental growth Source: MGI
  3. epithelial cell differentiation involved in prostate gland development Source: MGI
  4. prostate gland growth Source: MGI
  5. regulation of lipid metabolic process Source: MGI
  6. regulation of MAPK cascade Source: MGI
  7. sphingolipid metabolic process Source: InterPro
Complete GO annotation...

Enzyme and pathway databases

ReactomeiREACT_199008. Glycosphingolipid metabolism.

Names & Taxonomyi

Protein namesi
Recommended name:
Sulfated glycoprotein 1
Short name:
SGP-1
Alternative name(s):
Prosaposin
Gene namesi
Name:Psap
Synonyms:Sgp1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 10

Organism-specific databases

MGIiMGI:97783. Psap.

Subcellular locationi

GO - Cellular componenti

  1. extracellular space Source: UniProtKB-SubCell
  2. Golgi apparatus Source: Ensembl
  3. lysosome Source: InterPro
  4. mitochondrion Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1616 By similarityAdd
BLAST
Chaini17 – 557541Sulfated glycoprotein 1PRO_0000031626Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi63 ↔ 138 By similarity
Disulfide bondi66 ↔ 132 By similarity
Glycosylationi80 – 801N-linked (GlcNAc...)1 Publication
Disulfide bondi94 ↔ 106 By similarity
Disulfide bondi197 ↔ 273 By similarity
Disulfide bondi200 ↔ 267 By similarity
Glycosylationi214 – 2141N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi229 ↔ 240 By similarity
Disulfide bondi317 ↔ 390 By similarity
Disulfide bondi320 ↔ 384 By similarity
Glycosylationi334 – 3341N-linked (GlcNAc...)1 Publication
Disulfide bondi348 ↔ 359 By similarity
Disulfide bondi442 ↔ 515 By similarity
Disulfide bondi445 ↔ 509 By similarity
Glycosylationi459 – 4591N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi473 ↔ 484 By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

MaxQBiQ61207.
PaxDbiQ61207.
PRIDEiQ61207.

PTM databases

PhosphoSiteiQ61207.

Expressioni

Gene expression databases

ArrayExpressiQ61207.
BgeeiQ61207.
CleanExiMM_PSAP.
GenevestigatoriQ61207.

Interactioni

Protein-protein interaction databases

IntActiQ61207. 5 interactions.
MINTiMINT-1734080.

Structurei

3D structure databases

ProteinModelPortaliQ61207.
SMRiQ61207. Positions 60-139, 195-274, 315-391, 439-517.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini18 – 5841Saposin A-type 1Add
BLAST
Domaini59 – 14284Saposin B-type 1Add
BLAST
Domaini193 – 27785Saposin B-type 2Add
BLAST
Domaini313 – 39482Saposin B-type 3Add
BLAST
Domaini438 – 51982Saposin B-type 4Add
BLAST
Domaini521 – 55737Saposin A-type 2Add
BLAST

Sequence similaritiesi

Keywords - Domaini

Repeat, Signal

Phylogenomic databases

eggNOGiNOG269151.
GeneTreeiENSGT00530000063434.
HOGENOMiHOG000049216.
HOVERGENiHBG002617.
InParanoidiQ61207.
KOiK12382.
PhylomeDBiQ61207.

Family and domain databases

Gene3Di1.10.225.10. 4 hits.
InterProiIPR003119. SapA.
IPR007856. SapB_1.
IPR008138. SapB_2.
IPR008373. Saposin.
IPR011001. Saposin-like.
IPR021165. Saposin_chordata.
IPR008139. SaposinB.
[Graphical view]
PfamiPF02199. SapA. 2 hits.
PF05184. SapB_1. 4 hits.
PF03489. SapB_2. 4 hits.
[Graphical view]
PIRSFiPIRSF002431. Saposin. 1 hit.
PRINTSiPR01797. SAPOSIN.
SMARTiSM00162. SAPA. 2 hits.
SM00741. SapB. 4 hits.
[Graphical view]
SUPFAMiSSF47862. SSF47862. 3 hits.
PROSITEiPS51110. SAP_A. 2 hits.
PS50015. SAP_B. 4 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q61207-1 [UniParc]FASTAAdd to Basket

« Hide

MYALALFASL LATALTSPVQ DPKTCSGGSA VLCRDVKTAV DCGAVKHCQQ    50
MVWSKPTAKS LPCDICKTVV TEAGNLLKDN ATQEEILHYL EKTCEWIHDS 100
SLSASCKEVV DSYLPVILDM IKGEMSNPGE VCSALNLCQS LQEYLAEQNQ 150
KQLESNKIPE VDMARVVAPF MSNIPLLLYP QDHPRSQPQP KANEDVCQDC 200
MKLVSDVQTA VKTNSSFIQG FVDHVKEDCD RLGPGVSDIC KNYVDQYSEV 250
CVQMLMHMQD QQPKEICVLA GFCNEVKRVP MKTLVPATET IKNILPALEM 300
MDPYEQNLVQ AHNVILCQTC QFVMNKFSEL IVNNATEELL VKGLSNACAL 350
LPDPARTKCQ EVVGTFGPSL LDIFIHEVNP SSLCGVIGLC AARPELVEAL 400
EQPAPAIVSA LLKEPTPPKQ PAQPKQSALP AHVPPQKNGG FCEVCKKLVL 450
YLEHNLEKNS TKEEILAALE KGCSFLPDPY QKQCDDFVAE YEPLLLEILV 500
EVMDPGFVCS KIGVCPSAYK LLLGTEKCVW GPSYWCQNME TAARCNAVDH 550
CKRHVWN 557
Length:557
Mass (Da):61,422
Last modified:December 15, 1998 - v2
Checksum:i134593E20499E35E
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti83 – 831Q → E in AAB31059. 1 Publication
Sequence conflicti158 – 1581I → V in AAA92567. 1 Publication
Sequence conflicti160 – 1601Missing in AAB31059. 1 Publication
Sequence conflicti171 – 1722MS → SA in AAA92567. 1 Publication
Sequence conflicti244 – 2441V → L in AAB31059. 1 Publication
Sequence conflicti254 – 2541M → I in AAA92567. 1 Publication
Sequence conflicti255 – 2551L → W in AAB31059. 1 Publication
Sequence conflicti260 – 2623Missing1 Publication
Sequence conflicti307 – 3071N → D in AAB31059. 1 Publication
Sequence conflicti322 – 3221F → L in AAB31059. 1 Publication
Sequence conflicti349 – 3502AL → GV in AAB22175. 1 Publication
Sequence conflicti367 – 3671G → D in AAA92567. 1 Publication
Sequence conflicti370 – 3701L → Q in AAB31059. 1 Publication
Sequence conflicti373 – 3731I → D in AAA92567. 1 Publication
Sequence conflicti391 – 3911A → T1 Publication
Sequence conflicti393 – 3931R → L1 Publication
Sequence conflicti406 – 4061A → R1 Publication
Sequence conflicti406 – 4061A → R1 Publication
Sequence conflicti430 – 4301P → R in AAB31059. 1 Publication
Sequence conflicti445 – 4451C → F in AAA92567. 1 Publication
Sequence conflicti448 – 4481L → P in AAB02695. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
S36200 mRNA. Translation: AAB22175.1.
S71616 mRNA. Translation: AAB31059.1.
U27340 mRNA. Translation: AAA92567.1.
U57999 Genomic DNA. Translation: AAB02695.1.
CCDSiCCDS35911.1.
PIRiJH0604.
RefSeqiNP_001139592.1. NM_001146120.1.
NP_001139593.1. NM_001146121.1.
NP_001139594.1. NM_001146122.1.
NP_001139595.1. NM_001146123.1.
NP_001139596.1. NM_001146124.1.
NP_035309.3. NM_011179.3.
UniGeneiMm.277498.

Genome annotation databases

EnsembliENSMUST00000179238; ENSMUSP00000137476; ENSMUSG00000004207.
GeneIDi19156.
KEGGimmu:19156.
UCSCiuc007fen.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
S36200 mRNA. Translation: AAB22175.1 .
S71616 mRNA. Translation: AAB31059.1 .
U27340 mRNA. Translation: AAA92567.1 .
U57999 Genomic DNA. Translation: AAB02695.1 .
CCDSi CCDS35911.1.
PIRi JH0604.
RefSeqi NP_001139592.1. NM_001146120.1.
NP_001139593.1. NM_001146121.1.
NP_001139594.1. NM_001146122.1.
NP_001139595.1. NM_001146123.1.
NP_001139596.1. NM_001146124.1.
NP_035309.3. NM_011179.3.
UniGenei Mm.277498.

3D structure databases

ProteinModelPortali Q61207.
SMRi Q61207. Positions 60-139, 195-274, 315-391, 439-517.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

IntActi Q61207. 5 interactions.
MINTi MINT-1734080.

PTM databases

PhosphoSitei Q61207.

Proteomic databases

MaxQBi Q61207.
PaxDbi Q61207.
PRIDEi Q61207.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000179238 ; ENSMUSP00000137476 ; ENSMUSG00000004207 .
GeneIDi 19156.
KEGGi mmu:19156.
UCSCi uc007fen.2. mouse.

Organism-specific databases

CTDi 5660.
MGIi MGI:97783. Psap.

Phylogenomic databases

eggNOGi NOG269151.
GeneTreei ENSGT00530000063434.
HOGENOMi HOG000049216.
HOVERGENi HBG002617.
InParanoidi Q61207.
KOi K12382.
PhylomeDBi Q61207.

Enzyme and pathway databases

Reactomei REACT_199008. Glycosphingolipid metabolism.

Miscellaneous databases

ChiTaRSi PSAP. mouse.
NextBioi 295806.
PROi Q61207.
SOURCEi Search...

Gene expression databases

ArrayExpressi Q61207.
Bgeei Q61207.
CleanExi MM_PSAP.
Genevestigatori Q61207.

Family and domain databases

Gene3Di 1.10.225.10. 4 hits.
InterProi IPR003119. SapA.
IPR007856. SapB_1.
IPR008138. SapB_2.
IPR008373. Saposin.
IPR011001. Saposin-like.
IPR021165. Saposin_chordata.
IPR008139. SaposinB.
[Graphical view ]
Pfami PF02199. SapA. 2 hits.
PF05184. SapB_1. 4 hits.
PF03489. SapB_2. 4 hits.
[Graphical view ]
PIRSFi PIRSF002431. Saposin. 1 hit.
PRINTSi PR01797. SAPOSIN.
SMARTi SM00162. SAPA. 2 hits.
SM00741. SapB. 4 hits.
[Graphical view ]
SUPFAMi SSF47862. SSF47862. 3 hits.
PROSITEi PS51110. SAP_A. 2 hits.
PS50015. SAP_B. 4 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Liver.
  2. "Murine prosaposin: expression in the reproductive system of a gene implicated in human genetic diseases."
    Sprecher-Levy H., Orr-Urtreger A., Lonai P., Horowitz M.
    Cell. Mol. Biol. 39:287-299(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
  3. Erratum
    Sprecher-Levy H., Orr-Urtreger A., Lonai P., Horowitz M.
    Cell. Mol. Biol. 40:233-233(1994) [PubMed] [Europe PMC] [Abstract]
  4. "Expression of SGP-1 mRNA in preimplantation mouse embryos."
    Cao Q.P., Crain W.R.
    Dev. Genet. 17:263-271(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  5. Zhao Q.Q., Hay N.N., Morales C.R.
    Submitted (MAY-1996) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: BALB/c.
    Tissue: Liver.
  6. Lubec G., Kang S.U.
    Submitted (APR-2007) to UniProtKB
    Cited for: PROTEIN SEQUENCE OF 68-78 AND 463-482, IDENTIFICATION BY MASS SPECTROMETRY.
    Strain: C57BL/6.
    Tissue: Brain.
  7. "Mass-spectrometric identification and relative quantification of N-linked cell surface glycoproteins."
    Wollscheid B., Bausch-Fluck D., Henderson C., O'Brien R., Bibel M., Schiess R., Aebersold R., Watts J.D.
    Nat. Biotechnol. 27:378-386(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-80 AND ASN-334.

Entry informationi

Entry nameiSAP_MOUSE
AccessioniPrimary (citable) accession number: Q61207
Secondary accession number(s): Q60861, Q64006, Q64219
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 15, 1998
Last sequence update: December 15, 1998
Last modified: September 3, 2014
This is version 132 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi