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Protein

Platelet-activating factor acetylhydrolase IB subunit beta

Gene

Pafah1b2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Inactivates PAF by removing the acetyl group at the sn-2 position. This is a catalytic subunit.

Catalytic activityi

1-alkyl-2-acetyl-sn-glycero-3-phosphocholine + H2O = 1-alkyl-sn-glycero-3-phosphocholine + acetate.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei48By similarity1
Active sitei193By similarity1
Active sitei196By similarity1

GO - Molecular functioni

GO - Biological processi

  • brain development Source: GO_Central
  • lipid catabolic process Source: UniProtKB-KW
  • positive regulation of macroautophagy Source: MGI
  • spermatogenesis Source: MGI

Keywordsi

Molecular functionHydrolase
Biological processLipid degradation, Lipid metabolism

Enzyme and pathway databases

BRENDAi3.1.1.47 3474
ReactomeiR-MMU-6798695 Neutrophil degranulation
R-MMU-6811436 COPI-independent Golgi-to-ER retrograde traffic

Names & Taxonomyi

Protein namesi
Recommended name:
Platelet-activating factor acetylhydrolase IB subunit beta (EC:3.1.1.47)
Alternative name(s):
PAF acetylhydrolase 30 kDa subunit
Short name:
PAF-AH 30 kDa subunit
PAF-AH subunit beta
Short name:
PAFAH subunit beta
Gene namesi
Name:Pafah1b2
Synonyms:Pafahb
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 9

Organism-specific databases

MGIiMGI:108415 Pafah1b2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Chemistry databases

ChEMBLiCHEMBL3259481

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00000581522 – 229Platelet-activating factor acetylhydrolase IB subunit betaAdd BLAST228

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylserineBy similarity1
Modified residuei2PhosphoserineBy similarity1
Modified residuei64PhosphoserineCombined sources1
Modified residuei220PhosphothreonineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiQ61206
MaxQBiQ61206
PaxDbiQ61206
PeptideAtlasiQ61206
PRIDEiQ61206

2D gel databases

REPRODUCTION-2DPAGEIPI00118821
Q61206
UCD-2DPAGEQ61206

PTM databases

iPTMnetiQ61206
PhosphoSitePlusiQ61206
SwissPalmiQ61206

Expressioni

Developmental stagei

Expressed already by the time of neurulation. By E10.5, expression is abundant in the developing central and peripheral nervous systems. Major sites include the neuroepithelium of the fore-, mid-, and hindbrain, the spinal cord, the dorsal root, and cranial ganglia.

Gene expression databases

BgeeiENSMUSG00000003131
ExpressionAtlasiQ61206 baseline and differential
GenevisibleiQ61206 MM

Interactioni

Subunit structurei

Cytosolic PAF-AH IB is formed of three subunits of 45 kDa (alpha), 30 kDa (beta) and 29 kDa (gamma). The catalytic activity of the enzyme resides in the beta and gamma subunits, whereas the alpha subunit has regulatory activity. Trimer formation is not essential for the catalytic activity.

Binary interactionsi

WithEntry#Exp.IntActNotes
NudcO356852EBI-7445518,EBI-911192

GO - Molecular functioni

Protein-protein interaction databases

BioGridi202016, 3 interactors
IntActiQ61206, 4 interactors
MINTiQ61206
STRINGi10090.ENSMUSP00000127851

Chemistry databases

BindingDBiQ61206

Structurei

3D structure databases

ProteinModelPortaliQ61206
SMRiQ61206
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiENOG410IMK6 Eukaryota
ENOG410XPWQ LUCA
GeneTreeiENSGT00390000016520
HOGENOMiHOG000232143
HOVERGENiHBG053477
InParanoidiQ61206
OMAiRGQQPNK
OrthoDBiEOG091G0OII
PhylomeDBiQ61206
TreeFamiTF323955

Family and domain databases

Gene3Di3.40.50.1110, 1 hit
InterProiView protein in InterPro
IPR013830 SGNH_hydro
IPR036514 SGNH_hydro_sf
PfamiView protein in Pfam
PF13472 Lipase_GDSL_2, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q61206-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSQGDSNPAA IPHAAEDIQG DDRWMSQHNR FVLDCKDKEP DVLFVGDSMV
60 70 80 90 100
QLMQQYEIWR ELFSPLHALN FGIGGDTTRH VLWRLKNGEL ENIKPKVIVV
110 120 130 140 150
WVGTNNHENT AEEVAGGIEA IVQLINTRQP QAKIIVLGLL PRGEKPNPLR
160 170 180 190 200
QKNAKVNQLL KVSLPKLANV QLLDIDGGFV HSDGAISCHD MFDFLHLTGG
210 220
GYAKICKPLH ELIMQLLEET PEEKQTTIA
Length:229
Mass (Da):25,581
Last modified:May 1, 2007 - v2
Checksum:iB4D24048621AB182
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti129 – 130QP → HA in AAC52997 (PubMed:8954729).Curated2
Sequence conflicti188C → W in AAH56211 (PubMed:15489334).Curated1
Sequence conflicti222E → G in AAC52997 (PubMed:8954729).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U57747 mRNA Translation: AAC52997.1
AK153424 mRNA Translation: BAE31983.1
BC002037 mRNA Translation: AAH02037.1
BC056211 mRNA Translation: AAH56211.1
CCDSiCCDS23139.1
RefSeqiNP_032801.2, NM_008775.3
XP_006510147.1, XM_006510084.3
XP_006510148.1, XM_006510085.1
XP_017168698.1, XM_017313209.1
UniGeneiMm.200859
Mm.381810

Genome annotation databases

EnsembliENSMUST00000172450; ENSMUSP00000127851; ENSMUSG00000003131
ENSMUST00000214179; ENSMUSP00000149819; ENSMUSG00000003131
GeneIDi18475
UCSCiuc009pgx.1 mouse

Similar proteinsi

Entry informationi

Entry nameiPA1B2_MOUSE
AccessioniPrimary (citable) accession number: Q61206
Secondary accession number(s): Q6PKE6, Q7TNP3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: May 1, 2007
Last modified: May 23, 2018
This is version 143 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

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