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Q61205

- PA1B3_MOUSE

UniProt

Q61205 - PA1B3_MOUSE

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Protein

Platelet-activating factor acetylhydrolase IB subunit gamma

Gene

Pafah1b3

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Inactivates paf by removing the acetyl group at the sn-2 position. This is a catalytic subunit. Plays an important role during the development of brain.

Catalytic activityi

1-alkyl-2-acetyl-sn-glycero-3-phosphocholine + H2O = 1-alkyl-sn-glycero-3-phosphocholine + acetate.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei48 – 481By similarity
Active sitei193 – 1931By similarity
Active sitei196 – 1961By similarity

GO - Molecular functioni

  1. 1-alkyl-2-acetylglycerophosphocholine esterase activity Source: UniProtKB-EC

GO - Biological processi

  1. brain development Source: Ensembl
  2. lipid catabolic process Source: UniProtKB-KW
  3. spermatogenesis Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Lipid degradation, Lipid metabolism

Names & Taxonomyi

Protein namesi
Recommended name:
Platelet-activating factor acetylhydrolase IB subunit gamma (EC:3.1.1.47)
Alternative name(s):
PAF acetylhydrolase 29 kDa subunit
Short name:
PAF-AH 29 kDa subunit
PAF-AH subunit gamma
Short name:
PAFAH subunit gamma
Gene namesi
Name:Pafah1b3
Synonyms:Pafahg
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 7

Organism-specific databases

MGIiMGI:108414. Pafah1b3.

Subcellular locationi

GO - Cellular componenti

  1. cytoplasm Source: MGI
  2. cytosol Source: Ensembl
  3. extracellular vesicular exosome Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11RemovedBy similarity
Chaini2 – 232231Platelet-activating factor acetylhydrolase IB subunit gammaPRO_0000058156Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylserineBy similarity

Keywords - PTMi

Acetylation

Proteomic databases

MaxQBiQ61205.
PaxDbiQ61205.
PRIDEiQ61205.

2D gel databases

REPRODUCTION-2DPAGEQ61205.

PTM databases

PhosphoSiteiQ61205.

Expressioni

Developmental stagei

Expressed already by the time of neurulation. By E10.5, expression is abundant in the developing central and peripheral nervous systems. Major sites include the neuroepithelium of the fore-, mid-, and hindbrain, the spinal cord, the dorsal root, and cranial ganglia. In adult brain, expression is greatly diminished.

Gene expression databases

BgeeiQ61205.
ExpressionAtlasiQ61205. baseline and differential.
GenevestigatoriQ61205.

Interactioni

Subunit structurei

Cytosolic PAF-AH IB is formed of three subunits of 45 kDa (alpha), 30 kDa (beta) and 29 kDa (gamma). The catalytic activity of the enzyme resides in the beta and gamma subunits, whereas the alpha subunit has regulatory activity. Trimer formation is not essential for the catalytic activity.

Binary interactionsi

WithEntry#Exp.IntActNotes
Pafah1b1P630052EBI-1007637,EBI-917499

Protein-protein interaction databases

BioGridi202017. 2 interactions.
IntActiQ61205. 2 interactions.
MINTiMINT-4106434.

Structurei

3D structure databases

ProteinModelPortaliQ61205.
SMRiQ61205. Positions 6-208.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiNOG69837.
GeneTreeiENSGT00390000016520.
HOGENOMiHOG000232143.
HOVERGENiHBG053477.
InParanoidiQ61205.
KOiK16795.
OMAiFAPLHCL.
PhylomeDBiQ61205.
TreeFamiTF323955.

Family and domain databases

Gene3Di3.40.50.1110. 1 hit.
InterProiIPR013831. SGNH_hydro-type_esterase_dom.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q61205-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSGEGENPAS KPTPVQDVQG DGRWMSLHHR FVADSKDKEP EVVFIGDSLV
60 70 80 90 100
QLMHQCEIWR ELFSPLHALN FGIGGDSTQH VLWRLENGEL EHIRPKIVVV
110 120 130 140 150
WVGTNNHSHT AEQVTGGIKA IVQLVNKLQP QARVVVLGLL PRGQHPNPLR
160 170 180 190 200
EKNRQVNELV RAALAGYPRA HFLDADPGFV HSDGTISHHD MYDYLHLSRL
210 220 230
GYTPVCRALH SLLLRLLAQD QGQGIPLPET AS
Length:232
Mass (Da):25,853
Last modified:November 1, 1996 - v1
Checksum:i5D3C63E2A611670B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U57746 mRNA. Translation: AAC52996.1.
BC067015 mRNA. Translation: AAH67015.1.
CCDSiCCDS20979.1.
RefSeqiNP_032802.1. NM_008776.2.
UniGeneiMm.597.

Genome annotation databases

EnsembliENSMUST00000005583; ENSMUSP00000005583; ENSMUSG00000005447.
GeneIDi18476.
KEGGimmu:18476.
UCSCiuc009fsf.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U57746 mRNA. Translation: AAC52996.1 .
BC067015 mRNA. Translation: AAH67015.1 .
CCDSi CCDS20979.1.
RefSeqi NP_032802.1. NM_008776.2.
UniGenei Mm.597.

3D structure databases

ProteinModelPortali Q61205.
SMRi Q61205. Positions 6-208.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 202017. 2 interactions.
IntActi Q61205. 2 interactions.
MINTi MINT-4106434.

PTM databases

PhosphoSitei Q61205.

2D gel databases

REPRODUCTION-2DPAGE Q61205.

Proteomic databases

MaxQBi Q61205.
PaxDbi Q61205.
PRIDEi Q61205.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000005583 ; ENSMUSP00000005583 ; ENSMUSG00000005447 .
GeneIDi 18476.
KEGGi mmu:18476.
UCSCi uc009fsf.1. mouse.

Organism-specific databases

CTDi 5050.
MGIi MGI:108414. Pafah1b3.

Phylogenomic databases

eggNOGi NOG69837.
GeneTreei ENSGT00390000016520.
HOGENOMi HOG000232143.
HOVERGENi HBG053477.
InParanoidi Q61205.
KOi K16795.
OMAi FAPLHCL.
PhylomeDBi Q61205.
TreeFami TF323955.

Miscellaneous databases

NextBioi 294174.
PROi Q61205.
SOURCEi Search...

Gene expression databases

Bgeei Q61205.
ExpressionAtlasi Q61205. baseline and differential.
Genevestigatori Q61205.

Family and domain databases

Gene3Di 3.40.50.1110. 1 hit.
InterProi IPR013831. SGNH_hydro-type_esterase_dom.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Platelet-activating factor acetylhydrolase expression and activity suggest a link between neuronal migration and platelet-activating factor."
    Albrecht U., Abu-Issa R., Raetz B., Hattori M., Aoki J., Arai H., Inoue K., Eichele G.
    Dev. Biol. 180:579-593(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: BALB/c.
    Tissue: Brain.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6.
    Tissue: Brain.

Entry informationi

Entry nameiPA1B3_MOUSE
AccessioniPrimary (citable) accession number: Q61205
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: November 1, 1996
Last modified: October 29, 2014
This is version 108 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3