Platelet-activating factor acetylhydrolase IB subunit gamma

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Q61205 (PA1B3_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified April 3, 2013. Version 96. History...

Clusters with 100%, 90%, 50% identity |

Documents (2) |

Third-party data

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Names·Attributes·General annotation·Ontologies·Interactions·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents Customize order

Names and origin

Protein names

Recommended name:
Platelet-activating factor acetylhydrolase IB subunit gamma
EC=3.1.1.47

Alternative name(s):
PAF acetylhydrolase 29 kDa subunit
Short name=PAF-AH 29 kDa subunit
PAF-AH subunit gamma
Short name=PAFAH subunit gamma

Gene names

Name:	Pafah1b3
Synonyms:	Pafahg

Organism

Mus musculus (Mouse) [Reference proteome]

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length	232 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Inactivates paf by removing the acetyl group at the sn-2 position. This is a catalytic subunit. Plays an important role during the development of brain.
Catalytic activity	1-alkyl-2-acetyl-sn-glycero-3-phosphocholine + H₂O = 1-alkyl-sn-glycero-3-phosphocholine + acetate.
Subunit structure	Cytosolic PAF-AH IB is formed of three subunits of 45 kDa (alpha), 30 kDa (beta) and 29 kDa (gamma). The catalytic activity of the enzyme resides in the beta and gamma subunits, whereas the alpha subunit has regulatory activity. Trimer formation is not essential for the catalytic activity.
Subcellular location	Cytoplasm.
Developmental stage	Expressed already by the time of neurulation. By E10.5, expression is abundant in the developing central and peripheral nervous systems. Major sites include the neuroepithelium of the fore-, mid-, and hindbrain, the spinal cord, the dorsal root, and cranial ganglia. In adult brain, expression is greatly diminished.
Sequence similarities	Belongs to the 'GDSL' lipolytic enzyme family. Platelet-activating factor acetylhydrolase IB beta/gamma subunits subfamily.

Ontologies

Keywords
Biological process	Lipid degradation Lipid metabolism
Cellular component	Cytoplasm
Molecular function	Hydrolase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	brain development Inferred from electronic annotation. Source: Compara lipid catabolic process Inferred from electronic annotation. Source: UniProtKB-KW spermatogenesis Inferred from mutant phenotype PubMed 12551946. Source: MGI
Cellular_component	cytoplasm Inferred from direct assay PubMed 12551946. Source: MGI cytosol Inferred from electronic annotation. Source: Compara
Molecular_function	1-alkyl-2-acetylglycerophosphocholine esterase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Binary interactions

With	Entry	#Exp.	IntAct	Notes
Pafah1b1	P63005	2	EBI-1007637,EBI-917499

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – 232

232

Platelet-activating factor acetylhydrolase IB subunit gamma

PRO_0000058156

Sites

Active site

By similarity

Active site

193

By similarity

Active site

196

By similarity

Sequences

Sequence

Length

Mass (Da)

Tools

Q61205 [UniParc].

Last modified November 1, 1996. Version 1.
Checksum: 5D3C63E2A611670B
Show »

FASTA

232

25,853

        10         20         30         40         50         60 
MSGEGENPAS KPTPVQDVQG DGRWMSLHHR FVADSKDKEP EVVFIGDSLV QLMHQCEIWR 

        70         80         90        100        110        120 
ELFSPLHALN FGIGGDSTQH VLWRLENGEL EHIRPKIVVV WVGTNNHSHT AEQVTGGIKA 

       130        140        150        160        170        180 
IVQLVNKLQP QARVVVLGLL PRGQHPNPLR EKNRQVNELV RAALAGYPRA HFLDADPGFV 

       190        200        210        220        230 
HSDGTISHHD MYDYLHLSRL GYTPVCRALH SLLLRLLAQD QGQGIPLPET AS

« Hide

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Platelet-activating factor acetylhydrolase expression and activity suggest a link between neuronal migration and platelet-activating factor." Albrecht U., Abu-Issa R., Raetz B., Hattori M., Aoki J., Arai H., Inoue K., Eichele G. Dev. Biol. 180:579-593(1996) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Strain: BALB/c. Tissue: Brain.
[2]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: C57BL/6. Tissue: Brain.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	U57746 mRNA. Translation: AAC52996.1. BC067015 mRNA. Translation: AAH67015.1.
IPI	IPI00118819.
RefSeq	NP_032802.1. NM_008776.2.
UniGene	Mm.597.
3D structure databases
ProteinModelPortal	Q61205.
SMR	Q61205. Positions 6-208.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q61205. 1 interaction.
PTM databases
PhosphoSite	Q61205.
2D gel databases
REPRODUCTION-2DPAGE	Q61205.
Proteomic databases
PaxDb	Q61205.
PRIDE	Q61205.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSMUST00000005583; ENSMUSP00000005583; ENSMUSG00000005447.
GeneID	18476.
KEGG	mmu:18476.
Organism-specific databases
CTD	5050.
MGI	MGI:108414. Pafah1b3.
Phylogenomic databases
eggNOG	NOG69837.
GeneTree	ENSGT00390000016520.
HOGENOM	HOG000232143.
HOVERGEN	HBG053477.
InParanoid	Q61205.
KO	K16795.
OMA	FAPLHCL.
OrthoDB	EOG45QHF4.
Gene expression databases
ArrayExpress	Q61205.
Bgee	Q61205.
Genevestigator	Q61205.
GermOnline	ENSMUSG00000005447. Mus musculus.
Family and domain databases
Gene3D	3.40.50.1110. 1 hit.
InterPro	IPR013831. SGNH_hydro-type_esterase_dom. [Graphical view]
PROSITE	PS01098. LIPASE_GDSL_SER. False negative. [Graphical view]
ProtoNet	Search...
Other
NextBio	294174.
SOURCE	Search...

Entry information

Entry name

PA1B3_MOUSE

Accession

Primary (citable) accession number: Q61205

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 15, 1998
Last sequence update:	November 1, 1996
Last modified:	April 3, 2013
This is version 96 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Relevant documents

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

SIMILARITY comments

Index of protein domains and families

Names·Attributes·General annotation·Ontologies·Interactions·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents

Preferred order of sections

Names and origin

Protein attributes

General annotation (Comments)

Ontologies

Binary interactions

With

Entry

#Exp.

IntAct

Notes

Sequence annotation (Features)

Molecule processing

Sites

Sequences

References

Cross-references

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

2D gel databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Gene expression databases

Family and domain databases

Other

Entry information

Relevant documents