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Protein

Platelet-activating factor acetylhydrolase IB subunit gamma

Gene

Pafah1b3

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Inactivates paf by removing the acetyl group at the sn-2 position. This is a catalytic subunit. Plays an important role during the development of brain.

Catalytic activityi

1-alkyl-2-acetyl-sn-glycero-3-phosphocholine + H2O = 1-alkyl-sn-glycero-3-phosphocholine + acetate.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei48By similarity1
Active sitei193By similarity1
Active sitei196By similarity1

GO - Molecular functioni

GO - Biological processi

  • brain development Source: GO_Central
  • lipid catabolic process Source: UniProtKB-KW
  • spermatogenesis Source: MGI

Keywordsi

Molecular functionHydrolase
Biological processLipid degradation, Lipid metabolism

Enzyme and pathway databases

BRENDAi3.1.1.47 3474
ReactomeiR-MMU-6811436 COPI-independent Golgi-to-ER retrograde traffic

Names & Taxonomyi

Protein namesi
Recommended name:
Platelet-activating factor acetylhydrolase IB subunit gamma (EC:3.1.1.47)
Alternative name(s):
PAF acetylhydrolase 29 kDa subunit
Short name:
PAF-AH 29 kDa subunit
PAF-AH subunit gamma
Short name:
PAFAH subunit gamma
Gene namesi
Name:Pafah1b3
Synonyms:Pafahg
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 7

Organism-specific databases

MGIiMGI:108414 Pafah1b3

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Chemistry databases

ChEMBLiCHEMBL3259482

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00000581562 – 232Platelet-activating factor acetylhydrolase IB subunit gammaAdd BLAST231

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylserineBy similarity1
Modified residuei2PhosphoserineBy similarity1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiQ61205
MaxQBiQ61205
PaxDbiQ61205
PRIDEiQ61205

2D gel databases

REPRODUCTION-2DPAGEiQ61205

PTM databases

iPTMnetiQ61205
PhosphoSitePlusiQ61205
SwissPalmiQ61205

Expressioni

Developmental stagei

Expressed already by the time of neurulation. By E10.5, expression is abundant in the developing central and peripheral nervous systems. Major sites include the neuroepithelium of the fore-, mid-, and hindbrain, the spinal cord, the dorsal root, and cranial ganglia. In adult brain, expression is greatly diminished.

Gene expression databases

BgeeiENSMUSG00000005447
ExpressionAtlasiQ61205 baseline and differential
GenevisibleiQ61205 MM

Interactioni

Subunit structurei

Cytosolic PAF-AH IB is formed of three subunits of 45 kDa (alpha), 30 kDa (beta) and 29 kDa (gamma). The catalytic activity of the enzyme resides in the beta and gamma subunits, whereas the alpha subunit has regulatory activity. Trimer formation is not essential for the catalytic activity.

Binary interactionsi

WithEntry#Exp.IntActNotes
Pafah1b1P630052EBI-1007637,EBI-917499

GO - Molecular functioni

Protein-protein interaction databases

BioGridi202017, 2 interactors
IntActiQ61205, 2 interactors
MINTiQ61205
STRINGi10090.ENSMUSP00000005583

Structurei

3D structure databases

ProteinModelPortaliQ61205
SMRiQ61205
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG1388 Eukaryota
ENOG410XRW4 LUCA
GeneTreeiENSGT00390000016520
HOGENOMiHOG000232143
HOVERGENiHBG053477
InParanoidiQ61205
KOiK16795
OMAiHQDMYDY
OrthoDBiEOG091G0OII
PhylomeDBiQ61205
TreeFamiTF323955

Family and domain databases

Gene3Di3.40.50.1110, 1 hit
InterProiView protein in InterPro
IPR013830 SGNH_hydro
IPR036514 SGNH_hydro_sf
PfamiView protein in Pfam
PF13472 Lipase_GDSL_2, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q61205-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSGEGENPAS KPTPVQDVQG DGRWMSLHHR FVADSKDKEP EVVFIGDSLV
60 70 80 90 100
QLMHQCEIWR ELFSPLHALN FGIGGDSTQH VLWRLENGEL EHIRPKIVVV
110 120 130 140 150
WVGTNNHSHT AEQVTGGIKA IVQLVNKLQP QARVVVLGLL PRGQHPNPLR
160 170 180 190 200
EKNRQVNELV RAALAGYPRA HFLDADPGFV HSDGTISHHD MYDYLHLSRL
210 220 230
GYTPVCRALH SLLLRLLAQD QGQGIPLPET AS
Length:232
Mass (Da):25,853
Last modified:November 1, 1996 - v1
Checksum:i5D3C63E2A611670B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U57746 mRNA Translation: AAC52996.1
BC067015 mRNA Translation: AAH67015.1
CCDSiCCDS20979.1
RefSeqiNP_032802.1, NM_008776.2
XP_017177515.1, XM_017322026.1
XP_017177516.1, XM_017322027.1
UniGeneiMm.597

Genome annotation databases

EnsembliENSMUST00000005583; ENSMUSP00000005583; ENSMUSG00000005447
GeneIDi18476
KEGGimmu:18476
UCSCiuc009fsf.1 mouse

Similar proteinsi

Entry informationi

Entry nameiPA1B3_MOUSE
AccessioniPrimary (citable) accession number: Q61205
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: November 1, 1996
Last modified: March 28, 2018
This is version 133 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health