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Q61205

- PA1B3_MOUSE

UniProt

Q61205 - PA1B3_MOUSE

Protein

Platelet-activating factor acetylhydrolase IB subunit gamma

Gene

Pafah1b3

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 107 (01 Oct 2014)
      Sequence version 1 (01 Nov 1996)
      Previous versions | rss
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    Functioni

    Inactivates paf by removing the acetyl group at the sn-2 position. This is a catalytic subunit. Plays an important role during the development of brain.

    Catalytic activityi

    1-alkyl-2-acetyl-sn-glycero-3-phosphocholine + H2O = 1-alkyl-sn-glycero-3-phosphocholine + acetate.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei48 – 481By similarity
    Active sitei193 – 1931By similarity
    Active sitei196 – 1961By similarity

    GO - Molecular functioni

    1. 1-alkyl-2-acetylglycerophosphocholine esterase activity Source: UniProtKB-EC
    2. protein binding Source: IntAct

    GO - Biological processi

    1. brain development Source: Ensembl
    2. lipid catabolic process Source: UniProtKB-KW
    3. spermatogenesis Source: MGI

    Keywords - Molecular functioni

    Hydrolase

    Keywords - Biological processi

    Lipid degradation, Lipid metabolism

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Platelet-activating factor acetylhydrolase IB subunit gamma (EC:3.1.1.47)
    Alternative name(s):
    PAF acetylhydrolase 29 kDa subunit
    Short name:
    PAF-AH 29 kDa subunit
    PAF-AH subunit gamma
    Short name:
    PAFAH subunit gamma
    Gene namesi
    Name:Pafah1b3
    Synonyms:Pafahg
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 7

    Organism-specific databases

    MGIiMGI:108414. Pafah1b3.

    Subcellular locationi

    GO - Cellular componenti

    1. cytoplasm Source: MGI
    2. cytosol Source: Ensembl

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Initiator methioninei1 – 11RemovedBy similarity
    Chaini2 – 232231Platelet-activating factor acetylhydrolase IB subunit gammaPRO_0000058156Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei2 – 21N-acetylserineBy similarity

    Keywords - PTMi

    Acetylation

    Proteomic databases

    MaxQBiQ61205.
    PaxDbiQ61205.
    PRIDEiQ61205.

    2D gel databases

    REPRODUCTION-2DPAGEQ61205.

    PTM databases

    PhosphoSiteiQ61205.

    Expressioni

    Developmental stagei

    Expressed already by the time of neurulation. By E10.5, expression is abundant in the developing central and peripheral nervous systems. Major sites include the neuroepithelium of the fore-, mid-, and hindbrain, the spinal cord, the dorsal root, and cranial ganglia. In adult brain, expression is greatly diminished.

    Gene expression databases

    ArrayExpressiQ61205.
    BgeeiQ61205.
    GenevestigatoriQ61205.

    Interactioni

    Subunit structurei

    Cytosolic PAF-AH IB is formed of three subunits of 45 kDa (alpha), 30 kDa (beta) and 29 kDa (gamma). The catalytic activity of the enzyme resides in the beta and gamma subunits, whereas the alpha subunit has regulatory activity. Trimer formation is not essential for the catalytic activity.

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    Pafah1b1P630052EBI-1007637,EBI-917499

    Protein-protein interaction databases

    BioGridi202017. 2 interactions.
    IntActiQ61205. 2 interactions.
    MINTiMINT-4106434.

    Structurei

    3D structure databases

    ProteinModelPortaliQ61205.
    SMRiQ61205. Positions 6-208.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Phylogenomic databases

    eggNOGiNOG69837.
    GeneTreeiENSGT00390000016520.
    HOGENOMiHOG000232143.
    HOVERGENiHBG053477.
    InParanoidiQ61205.
    KOiK16795.
    OMAiFAPLHCL.
    PhylomeDBiQ61205.
    TreeFamiTF323955.

    Family and domain databases

    Gene3Di3.40.50.1110. 1 hit.
    InterProiIPR013831. SGNH_hydro-type_esterase_dom.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q61205-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSGEGENPAS KPTPVQDVQG DGRWMSLHHR FVADSKDKEP EVVFIGDSLV    50
    QLMHQCEIWR ELFSPLHALN FGIGGDSTQH VLWRLENGEL EHIRPKIVVV 100
    WVGTNNHSHT AEQVTGGIKA IVQLVNKLQP QARVVVLGLL PRGQHPNPLR 150
    EKNRQVNELV RAALAGYPRA HFLDADPGFV HSDGTISHHD MYDYLHLSRL 200
    GYTPVCRALH SLLLRLLAQD QGQGIPLPET AS 232
    Length:232
    Mass (Da):25,853
    Last modified:November 1, 1996 - v1
    Checksum:i5D3C63E2A611670B
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U57746 mRNA. Translation: AAC52996.1.
    BC067015 mRNA. Translation: AAH67015.1.
    CCDSiCCDS20979.1.
    RefSeqiNP_032802.1. NM_008776.2.
    UniGeneiMm.597.

    Genome annotation databases

    EnsembliENSMUST00000005583; ENSMUSP00000005583; ENSMUSG00000005447.
    GeneIDi18476.
    KEGGimmu:18476.
    UCSCiuc009fsf.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U57746 mRNA. Translation: AAC52996.1 .
    BC067015 mRNA. Translation: AAH67015.1 .
    CCDSi CCDS20979.1.
    RefSeqi NP_032802.1. NM_008776.2.
    UniGenei Mm.597.

    3D structure databases

    ProteinModelPortali Q61205.
    SMRi Q61205. Positions 6-208.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 202017. 2 interactions.
    IntActi Q61205. 2 interactions.
    MINTi MINT-4106434.

    PTM databases

    PhosphoSitei Q61205.

    2D gel databases

    REPRODUCTION-2DPAGE Q61205.

    Proteomic databases

    MaxQBi Q61205.
    PaxDbi Q61205.
    PRIDEi Q61205.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000005583 ; ENSMUSP00000005583 ; ENSMUSG00000005447 .
    GeneIDi 18476.
    KEGGi mmu:18476.
    UCSCi uc009fsf.1. mouse.

    Organism-specific databases

    CTDi 5050.
    MGIi MGI:108414. Pafah1b3.

    Phylogenomic databases

    eggNOGi NOG69837.
    GeneTreei ENSGT00390000016520.
    HOGENOMi HOG000232143.
    HOVERGENi HBG053477.
    InParanoidi Q61205.
    KOi K16795.
    OMAi FAPLHCL.
    PhylomeDBi Q61205.
    TreeFami TF323955.

    Miscellaneous databases

    NextBioi 294174.
    PROi Q61205.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q61205.
    Bgeei Q61205.
    Genevestigatori Q61205.

    Family and domain databases

    Gene3Di 3.40.50.1110. 1 hit.
    InterProi IPR013831. SGNH_hydro-type_esterase_dom.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Platelet-activating factor acetylhydrolase expression and activity suggest a link between neuronal migration and platelet-activating factor."
      Albrecht U., Abu-Issa R., Raetz B., Hattori M., Aoki J., Arai H., Inoue K., Eichele G.
      Dev. Biol. 180:579-593(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: BALB/c.
      Tissue: Brain.
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6.
      Tissue: Brain.

    Entry informationi

    Entry nameiPA1B3_MOUSE
    AccessioniPrimary (citable) accession number: Q61205
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 15, 1998
    Last sequence update: November 1, 1996
    Last modified: October 1, 2014
    This is version 107 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3