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Protein

Ral guanine nucleotide dissociation stimulator-like 2

Gene

Rgl2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Probable guanine nucleotide exchange factor. Putative effector of Ras and/or Rap. Associates with the GTP-bound form of Rap 1A and H-Ras in vitro.

GO - Molecular functioni

  • Rho guanyl-nucleotide exchange factor activity Source: MGI

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Guanine-nucleotide releasing factor

Enzyme and pathway databases

BRENDAi6.2.1.3. 3474.

Names & Taxonomyi

Protein namesi
Recommended name:
Ral guanine nucleotide dissociation stimulator-like 2
Short name:
RalGDS-like 2
Alternative name(s):
RalGDS-like factor
Ras-associated protein RAB2L
Gene namesi
Name:Rgl2
Synonyms:Rab2l, Rlf
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 17

Organism-specific databases

MGIiMGI:107483. Rgl2.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000688891 – 778Ral guanine nucleotide dissociation stimulator-like 2Add BLAST778

Proteomic databases

MaxQBiQ61193.
PaxDbiQ61193.
PeptideAtlasiQ61193.
PRIDEiQ61193.

PTM databases

iPTMnetiQ61193.
PhosphoSitePlusiQ61193.

Expressioni

Gene expression databases

BgeeiENSMUSG00000041354.
CleanExiMM_RLF.
ExpressionAtlasiQ61193. baseline and differential.
GenevisibleiQ61193. MM.

Interactioni

Subunit structurei

Interacts with SAMD9.By similarity

Protein-protein interaction databases

IntActiQ61193. 3 interactors.
MINTiMINT-1582342.
STRINGi10090.ENSMUSP00000041082.

Structurei

Secondary structure

1778
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi52 – 62Combined sources11
Beta strandi65 – 74Combined sources10
Beta strandi87 – 95Combined sources9
Helixi97 – 104Combined sources8
Helixi109 – 112Combined sources4
Helixi116 – 123Combined sources8
Helixi124 – 126Combined sources3
Helixi130 – 142Combined sources13
Turni143 – 146Combined sources4
Helixi149 – 169Combined sources21
Helixi171 – 173Combined sources3
Helixi176 – 178Combined sources3
Helixi179 – 192Combined sources14
Helixi205 – 213Combined sources9
Helixi236 – 241Combined sources6
Helixi244 – 260Combined sources17
Helixi264 – 267Combined sources4
Turni269 – 271Combined sources3
Turni273 – 276Combined sources4
Helixi285 – 305Combined sources21
Beta strandi308 – 310Combined sources3
Beta strandi312 – 314Combined sources3
Beta strandi318 – 320Combined sources3
Helixi325 – 344Combined sources20
Helixi348 – 359Combined sources12
Helixi361 – 364Combined sources4
Helixi367 – 371Combined sources5
Helixi375 – 385Combined sources11
Turni398 – 400Combined sources3
Helixi433 – 445Combined sources13
Helixi457 – 477Combined sources21
Helixi486 – 494Combined sources9
Helixi500 – 510Combined sources11
Beta strandi650 – 657Combined sources8
Beta strandi660 – 662Combined sources3
Beta strandi668 – 672Combined sources5
Helixi680 – 687Combined sources8
Turni688 – 691Combined sources4
Beta strandi698 – 702Combined sources5
Turni703 – 706Combined sources4
Helixi719 – 722Combined sources4
Beta strandi727 – 733Combined sources7

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1RLFNMR-A646-735[»]
4JGWX-ray2.30A/B50-514[»]
5CM8X-ray2.60A50-514[»]
5CM9X-ray2.60A/B50-514[»]
ProteinModelPortaliQ61193.
SMRiQ61193.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ61193.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini88 – 212N-terminal Ras-GEFPROSITE-ProRule annotationAdd BLAST125
Domaini243 – 513Ras-GEFPROSITE-ProRule annotationAdd BLAST271
Domaini649 – 736Ras-associatingPROSITE-ProRule annotationAdd BLAST88

Sequence similaritiesi

Contains 1 N-terminal Ras-GEF domain.PROSITE-ProRule annotation
Contains 1 Ras-associating domain.PROSITE-ProRule annotation
Contains 1 Ras-GEF domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiENOG410KDSG. Eukaryota.
ENOG4110VI4. LUCA.
GeneTreeiENSGT00860000133700.
HOGENOMiHOG000231592.
HOVERGENiHBG005864.
InParanoidiQ61193.
KOiK17636.
OMAiNLVPSQC.
OrthoDBiEOG091G0761.
PhylomeDBiQ61193.
TreeFamiTF315204.

Family and domain databases

CDDicd00155. RasGEF. 1 hit.
cd06224. REM. 1 hit.
Gene3Di1.10.840.10. 1 hit.
InterProiIPR000159. RA_dom.
IPR000651. Ras-like_Gua-exchang_fac_N.
IPR019804. Ras_G-nucl-exch_fac_CS.
IPR023578. Ras_GEF_dom.
IPR001895. RASGEF_cat_dom.
IPR029071. Ubiquitin-rel_dom.
[Graphical view]
PfamiPF00788. RA. 1 hit.
PF00617. RasGEF. 1 hit.
PF00618. RasGEF_N. 1 hit.
[Graphical view]
SMARTiSM00314. RA. 1 hit.
SM00147. RasGEF. 1 hit.
SM00229. RasGEFN. 1 hit.
[Graphical view]
SUPFAMiSSF48366. SSF48366. 1 hit.
SSF54236. SSF54236. 1 hit.
PROSITEiPS50200. RA. 1 hit.
PS00720. RASGEF. 1 hit.
PS50009. RASGEF_CAT. 1 hit.
PS50212. RASGEF_NTER. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q61193-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLPRPLRLLL DTTPPGGVVL SSFRSRDPEE GGDPGGRAVG GGQEEEDEEE
60 70 80 90 100
EEASVSVWDE EEDGATFTVT SRQYRPLDPL APLPPPRSSR RLRAGTLEAL
110 120 130 140 150
VRHLLDARTA GADMMFTPAL LATHRAFTST PALFGLVADR LEALESHPPG
160 170 180 190 200
ELERTTGVAI SVLSTWLASH PEDFGSEVKG QLDRLESFLL RTGYAAREGV
210 220 230 240 250
VGGSADLIRN LRARVDPRAP DLPKPLALPG DSPADPTDVL VFLADHLAEQ
260 270 280 290 300
LTLLDAELFL NLIPSQCLGG LWGHRDRPGH SHLCPSVRAT VTQFNKVAGA
310 320 330 340 350
VVSSVLGATS IGEGPREVTV RPLRPPQRAR LLEKWIRVAE ECRLLRNFSS
360 370 380 390 400
VYAVVSALQS SPIHRLRAAW GETTRDSLRV FSSLCQIFSE EDNYSQSREL
410 420 430 440 450
LMQEVKPQPP VEPHSKKAPR SGFRGGGVVP YLGTFLKDLV MLDAASKDEL
460 470 480 490 500
ENGYINFDKR RKEFAILSEL LRLQKECRGY DLRPNSDIQQ WLQGLQPLTE
510 520 530 540 550
AQSHRVSCEV EPPGTSDSPA ARTPRPTLVI TQWTEVLGSV GGPTPLVSWD
560 570 580 590 600
RPSVGGDEVP GTPAPLLTRL AQHMKWPSVS SLDSALESSP SLHSPADPGH
610 620 630 640 650
LSPPASSPRP SRGHRRSASC GSPLSGNTGE GTSRSAGCGG GVSGPGSSDC
660 670 680 690 700
RIIRVQMELG EDGSVYKSIL VTSQDKAPSV ISRVLKKNNR DSAVASEFEL
710 720 730 740 750
VQLLPGDREL TIPHSANVFY AMDGASHDFL LRQRRRPSAA TPGSHSGPSA
760 770
SGTPPSEGGG GSFPRIKATG RKIARALF
Length:778
Mass (Da):83,826
Last modified:June 20, 2001 - v2
Checksum:iB23CB882A5416564
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti147H → Y in AAC52724 (PubMed:8710374).Curated1
Sequence conflicti402M → T in AAC52724 (PubMed:8710374).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U54639 mRNA. Translation: AAC52724.1.
AF110520 Genomic DNA. Translation: AAC97974.1.
AF100956 Genomic DNA. Translation: AAC69894.1.
BC068121 mRNA. Translation: AAH68121.1.
CCDSiCCDS28635.1.
PIRiPC4379.
RefSeqiNP_033085.2. NM_009059.2.
UniGeneiMm.43777.

Genome annotation databases

EnsembliENSMUST00000047503; ENSMUSP00000041082; ENSMUSG00000041354.
GeneIDi19732.
KEGGimmu:19732.
UCSCiuc008cag.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U54639 mRNA. Translation: AAC52724.1.
AF110520 Genomic DNA. Translation: AAC97974.1.
AF100956 Genomic DNA. Translation: AAC69894.1.
BC068121 mRNA. Translation: AAH68121.1.
CCDSiCCDS28635.1.
PIRiPC4379.
RefSeqiNP_033085.2. NM_009059.2.
UniGeneiMm.43777.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1RLFNMR-A646-735[»]
4JGWX-ray2.30A/B50-514[»]
5CM8X-ray2.60A50-514[»]
5CM9X-ray2.60A/B50-514[»]
ProteinModelPortaliQ61193.
SMRiQ61193.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ61193. 3 interactors.
MINTiMINT-1582342.
STRINGi10090.ENSMUSP00000041082.

PTM databases

iPTMnetiQ61193.
PhosphoSitePlusiQ61193.

Proteomic databases

MaxQBiQ61193.
PaxDbiQ61193.
PeptideAtlasiQ61193.
PRIDEiQ61193.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000047503; ENSMUSP00000041082; ENSMUSG00000041354.
GeneIDi19732.
KEGGimmu:19732.
UCSCiuc008cag.1. mouse.

Organism-specific databases

CTDi5863.
MGIiMGI:107483. Rgl2.

Phylogenomic databases

eggNOGiENOG410KDSG. Eukaryota.
ENOG4110VI4. LUCA.
GeneTreeiENSGT00860000133700.
HOGENOMiHOG000231592.
HOVERGENiHBG005864.
InParanoidiQ61193.
KOiK17636.
OMAiNLVPSQC.
OrthoDBiEOG091G0761.
PhylomeDBiQ61193.
TreeFamiTF315204.

Enzyme and pathway databases

BRENDAi6.2.1.3. 3474.

Miscellaneous databases

EvolutionaryTraceiQ61193.
PROiQ61193.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000041354.
CleanExiMM_RLF.
ExpressionAtlasiQ61193. baseline and differential.
GenevisibleiQ61193. MM.

Family and domain databases

CDDicd00155. RasGEF. 1 hit.
cd06224. REM. 1 hit.
Gene3Di1.10.840.10. 1 hit.
InterProiIPR000159. RA_dom.
IPR000651. Ras-like_Gua-exchang_fac_N.
IPR019804. Ras_G-nucl-exch_fac_CS.
IPR023578. Ras_GEF_dom.
IPR001895. RASGEF_cat_dom.
IPR029071. Ubiquitin-rel_dom.
[Graphical view]
PfamiPF00788. RA. 1 hit.
PF00617. RasGEF. 1 hit.
PF00618. RasGEF_N. 1 hit.
[Graphical view]
SMARTiSM00314. RA. 1 hit.
SM00147. RasGEF. 1 hit.
SM00229. RasGEFN. 1 hit.
[Graphical view]
SUPFAMiSSF48366. SSF48366. 1 hit.
SSF54236. SSF54236. 1 hit.
PROSITEiPS50200. RA. 1 hit.
PS00720. RASGEF. 1 hit.
PS50009. RASGEF_CAT. 1 hit.
PS50212. RASGEF_NTER. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiRGL2_MOUSE
AccessioniPrimary (citable) accession number: Q61193
Secondary accession number(s): Q9QUJ2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1999
Last sequence update: June 20, 2001
Last modified: November 30, 2016
This is version 149 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.