Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Q61190

- I10R2_MOUSE

UniProt

Q61190 - I10R2_MOUSE

Protein

Interleukin-10 receptor subunit beta

Gene

Il10rb

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 112 (01 Oct 2014)
      Sequence version 1 (01 Nov 1996)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Shared cell surface receptor required for the activation of five class 2 cytokines: IL10, IL22, IL26, IL28, and IFNL1. The IFNLR1/IL10RB dimer is a receptor for the cytokine ligands IFNL2 and IFNL3 and mediates their antiviral activity. The ligand/receptor complex stimulate the activation of the JAK/STAT signaling pathway leading to the expression of IFN-stimulated genes (ISG), which contribute to the antiviral state By similarity.By similarity

    GO - Molecular functioni

    1. interleukin-10 receptor activity Source: MGI
    2. protein binding Source: MGI

    GO - Biological processi

    1. cytokine-mediated signaling pathway Source: GOC

    Keywords - Molecular functioni

    Receptor

    Keywords - Biological processi

    Antiviral defense

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Interleukin-10 receptor subunit beta
    Short name:
    IL-10 receptor subunit beta
    Short name:
    IL-10R subunit beta
    Short name:
    IL-10RB
    Alternative name(s):
    Cytokine receptor class-II member 4
    Cytokine receptor family 2 member 4
    Short name:
    CRF2-4
    Interleukin-10 receptor subunit 2
    Short name:
    IL-10R subunit 2
    Short name:
    IL-10R2
    CD_antigen: CDw210b
    Gene namesi
    Name:Il10rb
    Synonyms:Crfb4
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Unplaced

    Organism-specific databases

    MGIiMGI:109380. Il10rb.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW

    Keywords - Cellular componenti

    Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 1919Sequence AnalysisAdd
    BLAST
    Chaini20 – 349330Interleukin-10 receptor subunit betaPRO_0000011015Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi49 – 491N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi66 ↔ 74By similarity
    Glycosylationi102 – 1021N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi161 – 1611N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi188 ↔ 209By similarity
    Glycosylationi199 – 1991N-linked (GlcNAc...)Sequence Analysis
    Modified residuei299 – 2991Phosphoserine1 Publication

    Keywords - PTMi

    Disulfide bond, Glycoprotein, Phosphoprotein

    Proteomic databases

    PRIDEiQ61190.

    PTM databases

    PhosphoSiteiQ61190.

    Expressioni

    Gene expression databases

    CleanExiMM_IL10RB.
    GenevestigatoriQ61190.

    Interactioni

    Subunit structurei

    Heterodimer with IFNLR1.By similarity

    Structurei

    3D structure databases

    ProteinModelPortaliQ61190.
    SMRiQ61190. Positions 20-220.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini20 – 220201ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini242 – 349108CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei221 – 24121HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini23 – 11189Fibronectin type-III 1PROSITE-ProRule annotationAdd
    BLAST
    Domaini112 – 215104Fibronectin type-III 2PROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Belongs to the type II cytokine receptor family.Curated
    Contains 2 fibronectin type-III domains.PROSITE-ProRule annotation

    Keywords - Domaini

    Repeat, Signal, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG47180.
    HOVERGENiHBG052057.
    InParanoidiQ61190.

    Family and domain databases

    Gene3Di2.60.40.10. 1 hit.
    InterProiIPR003961. Fibronectin_type3.
    IPR013783. Ig-like_fold.
    IPR015373. Interferon_alpha/beta_rcpt_bsu.
    [Graphical view]
    PfamiPF09294. Interfer-bind. 1 hit.
    PF01108. Tissue_fac. 1 hit.
    [Graphical view]
    SMARTiSM00060. FN3. 2 hits.
    [Graphical view]
    SUPFAMiSSF49265. SSF49265. 2 hits.
    PROSITEiPS50853. FN3. 2 hits.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q61190-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAPCVAGWLG GFLLVPALGM IPPPEKVRMN SVNFKNILQW EVPAFPKTNL    50
    TFTAQYESYR SFQDHCKRTA STQCDFSHLS KYGDYTVRVR AELADEHSEW 100
    VNVTFCPVED TIIGPPEMQI ESLAESLHLR FSAPQIENEP ETWTLKNIYD 150
    SWAYRVQYWK NGTNEKFQVV SPYDSEVLRN LEPWTTYCIQ VQGFLLDQNR 200
    TGEWSEPICE RTGNDEITPS WIVAIILIVS VLVVFLFLLG CFVVLWLIYK 250
    KTKHTFRSGT SLPQHLKEFL GHPHHSTFLL FSFPPPEEAE VFDKLSIISE 300
    ESEGSKQSPE DNCASEPPSD PGPRELESKD EAPSPPHDDP KLLTSTSEV 349
    Length:349
    Mass (Da):39,774
    Last modified:November 1, 1996 - v1
    Checksum:i58BA4F6B86330A39
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U53696 mRNA. Translation: AAC53062.1.
    UniGeneiMm.4154.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U53696 mRNA. Translation: AAC53062.1 .
    UniGenei Mm.4154.

    3D structure databases

    ProteinModelPortali Q61190.
    SMRi Q61190. Positions 20-220.
    ModBasei Search...
    MobiDBi Search...

    PTM databases

    PhosphoSitei Q61190.

    Proteomic databases

    PRIDEi Q61190.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Organism-specific databases

    MGIi MGI:109380. Il10rb.

    Phylogenomic databases

    eggNOGi NOG47180.
    HOVERGENi HBG052057.
    InParanoidi Q61190.

    Miscellaneous databases

    ChiTaRSi IL10RB. mouse.
    PROi Q61190.
    SOURCEi Search...

    Gene expression databases

    CleanExi MM_IL10RB.
    Genevestigatori Q61190.

    Family and domain databases

    Gene3Di 2.60.40.10. 1 hit.
    InterProi IPR003961. Fibronectin_type3.
    IPR013783. Ig-like_fold.
    IPR015373. Interferon_alpha/beta_rcpt_bsu.
    [Graphical view ]
    Pfami PF09294. Interfer-bind. 1 hit.
    PF01108. Tissue_fac. 1 hit.
    [Graphical view ]
    SMARTi SM00060. FN3. 2 hits.
    [Graphical view ]
    SUPFAMi SSF49265. SSF49265. 2 hits.
    PROSITEi PS50853. FN3. 2 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "CRF2-4: isolation of cDNA clones encoding the human and mouse proteins."
      Gibbs V.C., Pennica D.
      Gene 186:97-101(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    2. "The orphan receptor CRF2-4 is an essential subunit of the interleukin 10 receptor."
      Spencer S.D., Di Marco F., Hooley J., Pitts-Meek S., Bauer M., Ryan A.M., Sordat B., Gibbs V.C., Aguet M.
      J. Exp. Med. 187:571-578(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: CHARACTERIZATION.
    3. "The phagosomal proteome in interferon-gamma-activated macrophages."
      Trost M., English L., Lemieux S., Courcelles M., Desjardins M., Thibault P.
      Immunity 30:143-154(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-299, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiI10R2_MOUSE
    AccessioniPrimary (citable) accession number: Q61190
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 1, 2000
    Last sequence update: November 1, 1996
    Last modified: October 1, 2014
    This is version 112 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3