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Protein

Interleukin-10 receptor subunit beta

Gene

Il10rb

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Shared cell surface receptor required for the activation of five class 2 cytokines: IL10, IL22, IL26, IL28, and IFNL1. The IFNLR1/IL10RB dimer is a receptor for the cytokine ligands IFNL2 and IFNL3 and mediates their antiviral activity. The ligand/receptor complex stimulate the activation of the JAK/STAT signaling pathway leading to the expression of IFN-stimulated genes (ISG), which contribute to the antiviral state (By similarity).By similarity

GO - Molecular functioni

  • interleukin-10 receptor activity Source: MGI

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Receptor

Keywords - Biological processi

Antiviral defense

Names & Taxonomyi

Protein namesi
Recommended name:
Interleukin-10 receptor subunit beta
Short name:
IL-10 receptor subunit beta
Short name:
IL-10R subunit beta
Short name:
IL-10RB
Alternative name(s):
Cytokine receptor class-II member 4
Cytokine receptor family 2 member 4
Short name:
CRF2-4
Interleukin-10 receptor subunit 2
Short name:
IL-10R subunit 2
Short name:
IL-10R2
CD_antigen: CDw210b
Gene namesi
Name:Il10rb
Synonyms:Crfb4
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Unplaced

Organism-specific databases

MGIiMGI:109380. Il10rb.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini20 – 220ExtracellularSequence analysisAdd BLAST201
Transmembranei221 – 241HelicalSequence analysisAdd BLAST21
Topological domaini242 – 349CytoplasmicSequence analysisAdd BLAST108

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 19Sequence analysisAdd BLAST19
ChainiPRO_000001101520 – 349Interleukin-10 receptor subunit betaAdd BLAST330

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi49N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi66 ↔ 74By similarity
Glycosylationi102N-linked (GlcNAc...)Sequence analysis1
Glycosylationi161N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi188 ↔ 209By similarity
Glycosylationi199N-linked (GlcNAc...)Sequence analysis1
Modified residuei299PhosphoserineCombined sources1

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

MaxQBiQ61190.
PaxDbiQ61190.
PRIDEiQ61190.

PTM databases

iPTMnetiQ61190.
PhosphoSitePlusiQ61190.

Expressioni

Gene expression databases

CleanExiMM_IL10RB.

Interactioni

Subunit structurei

Heterodimer with IFNLR1.By similarity

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000023691.

Structurei

3D structure databases

ProteinModelPortaliQ61190.
SMRiQ61190.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini23 – 111Fibronectin type-III 1PROSITE-ProRule annotationAdd BLAST89
Domaini112 – 215Fibronectin type-III 2PROSITE-ProRule annotationAdd BLAST104

Sequence similaritiesi

Belongs to the type II cytokine receptor family.Curated
Contains 2 fibronectin type-III domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IER7. Eukaryota.
ENOG410YTBJ. LUCA.
HOVERGENiHBG052057.
InParanoidiQ61190.

Family and domain databases

CDDicd00063. FN3. 2 hits.
Gene3Di2.60.40.10. 1 hit.
InterProiIPR003961. FN3_dom.
IPR013783. Ig-like_fold.
IPR015373. Interferon/interleukin_rcp_dom.
[Graphical view]
PfamiPF09294. Interfer-bind. 1 hit.
PF01108. Tissue_fac. 1 hit.
[Graphical view]
SMARTiSM00060. FN3. 2 hits.
[Graphical view]
SUPFAMiSSF49265. SSF49265. 2 hits.
PROSITEiPS50853. FN3. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q61190-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAPCVAGWLG GFLLVPALGM IPPPEKVRMN SVNFKNILQW EVPAFPKTNL
60 70 80 90 100
TFTAQYESYR SFQDHCKRTA STQCDFSHLS KYGDYTVRVR AELADEHSEW
110 120 130 140 150
VNVTFCPVED TIIGPPEMQI ESLAESLHLR FSAPQIENEP ETWTLKNIYD
160 170 180 190 200
SWAYRVQYWK NGTNEKFQVV SPYDSEVLRN LEPWTTYCIQ VQGFLLDQNR
210 220 230 240 250
TGEWSEPICE RTGNDEITPS WIVAIILIVS VLVVFLFLLG CFVVLWLIYK
260 270 280 290 300
KTKHTFRSGT SLPQHLKEFL GHPHHSTFLL FSFPPPEEAE VFDKLSIISE
310 320 330 340
ESEGSKQSPE DNCASEPPSD PGPRELESKD EAPSPPHDDP KLLTSTSEV
Length:349
Mass (Da):39,774
Last modified:November 1, 1996 - v1
Checksum:i58BA4F6B86330A39
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U53696 mRNA. Translation: AAC53062.1.
UniGeneiMm.4154.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U53696 mRNA. Translation: AAC53062.1.
UniGeneiMm.4154.

3D structure databases

ProteinModelPortaliQ61190.
SMRiQ61190.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000023691.

PTM databases

iPTMnetiQ61190.
PhosphoSitePlusiQ61190.

Proteomic databases

MaxQBiQ61190.
PaxDbiQ61190.
PRIDEiQ61190.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Organism-specific databases

MGIiMGI:109380. Il10rb.

Phylogenomic databases

eggNOGiENOG410IER7. Eukaryota.
ENOG410YTBJ. LUCA.
HOVERGENiHBG052057.
InParanoidiQ61190.

Miscellaneous databases

ChiTaRSiIl10rb. mouse.
PROiQ61190.
SOURCEiSearch...

Gene expression databases

CleanExiMM_IL10RB.

Family and domain databases

CDDicd00063. FN3. 2 hits.
Gene3Di2.60.40.10. 1 hit.
InterProiIPR003961. FN3_dom.
IPR013783. Ig-like_fold.
IPR015373. Interferon/interleukin_rcp_dom.
[Graphical view]
PfamiPF09294. Interfer-bind. 1 hit.
PF01108. Tissue_fac. 1 hit.
[Graphical view]
SMARTiSM00060. FN3. 2 hits.
[Graphical view]
SUPFAMiSSF49265. SSF49265. 2 hits.
PROSITEiPS50853. FN3. 2 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiI10R2_MOUSE
AccessioniPrimary (citable) accession number: Q61190
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: November 1, 1996
Last modified: November 30, 2016
This is version 126 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.