Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

Q61190 (I10R2_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified June 11, 2014. Version 110. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Interleukin-10 receptor subunit beta

Short name=IL-10 receptor subunit beta
Short name=IL-10R subunit beta
Short name=IL-10RB
Alternative name(s):
Cytokine receptor class-II member 4
Cytokine receptor family 2 member 4
Short name=CRF2-4
Interleukin-10 receptor subunit 2
Short name=IL-10R subunit 2
Short name=IL-10R2
CD_antigen=CDw210b
Gene names
Name:Il10rb
Synonyms:Crfb4
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length349 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Shared cell surface receptor required for the activation of five class 2 cytokines: IL10, IL22, IL26, IL28, and IFNL1 By similarity.

Subcellular location

Membrane; Single-pass type I membrane protein.

Sequence similarities

Belongs to the type II cytokine receptor family.

Contains 2 fibronectin type-III domains.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 1919 Potential
Chain20 – 349330Interleukin-10 receptor subunit beta
PRO_0000011015

Regions

Topological domain20 – 220201Extracellular Potential
Transmembrane221 – 24121Helical; Potential
Topological domain242 – 349108Cytoplasmic Potential
Domain23 – 11189Fibronectin type-III 1
Domain112 – 215104Fibronectin type-III 2

Amino acid modifications

Modified residue2991Phosphoserine Ref.3
Glycosylation491N-linked (GlcNAc...) Potential
Glycosylation1021N-linked (GlcNAc...) Potential
Glycosylation1611N-linked (GlcNAc...) Potential
Glycosylation1991N-linked (GlcNAc...) Potential
Disulfide bond66 ↔ 74 By similarity
Disulfide bond188 ↔ 209 By similarity

Sequences

Sequence LengthMass (Da)Tools
Q61190 [UniParc].

Last modified November 1, 1996. Version 1.
Checksum: 58BA4F6B86330A39

FASTA34939,774
        10         20         30         40         50         60 
MAPCVAGWLG GFLLVPALGM IPPPEKVRMN SVNFKNILQW EVPAFPKTNL TFTAQYESYR 

        70         80         90        100        110        120 
SFQDHCKRTA STQCDFSHLS KYGDYTVRVR AELADEHSEW VNVTFCPVED TIIGPPEMQI 

       130        140        150        160        170        180 
ESLAESLHLR FSAPQIENEP ETWTLKNIYD SWAYRVQYWK NGTNEKFQVV SPYDSEVLRN 

       190        200        210        220        230        240 
LEPWTTYCIQ VQGFLLDQNR TGEWSEPICE RTGNDEITPS WIVAIILIVS VLVVFLFLLG 

       250        260        270        280        290        300 
CFVVLWLIYK KTKHTFRSGT SLPQHLKEFL GHPHHSTFLL FSFPPPEEAE VFDKLSIISE 

       310        320        330        340 
ESEGSKQSPE DNCASEPPSD PGPRELESKD EAPSPPHDDP KLLTSTSEV 

« Hide

References

« Hide 'large scale' references
[1]"CRF2-4: isolation of cDNA clones encoding the human and mouse proteins."
Gibbs V.C., Pennica D.
Gene 186:97-101(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]"The orphan receptor CRF2-4 is an essential subunit of the interleukin 10 receptor."
Spencer S.D., Di Marco F., Hooley J., Pitts-Meek S., Bauer M., Ryan A.M., Sordat B., Gibbs V.C., Aguet M.
J. Exp. Med. 187:571-578(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: CHARACTERIZATION.
[3]"The phagosomal proteome in interferon-gamma-activated macrophages."
Trost M., English L., Lemieux S., Courcelles M., Desjardins M., Thibault P.
Immunity 30:143-154(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-299, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
U53696 mRNA. Translation: AAC53062.1.
UniGeneMm.4154.

3D structure databases

ProteinModelPortalQ61190.
SMRQ61190. Positions 20-220.
ModBaseSearch...
MobiDBSearch...

PTM databases

PhosphoSiteQ61190.

Proteomic databases

PRIDEQ61190.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Organism-specific databases

MGIMGI:109380. Il10rb.

Phylogenomic databases

eggNOGNOG47180.
HOVERGENHBG052057.
InParanoidQ61190.

Gene expression databases

CleanExMM_IL10RB.
GenevestigatorQ61190.

Family and domain databases

Gene3D2.60.40.10. 1 hit.
InterProIPR003961. Fibronectin_type3.
IPR013783. Ig-like_fold.
IPR015373. Interferon_alpha/beta_rcpt_bsu.
[Graphical view]
PfamPF09294. Interfer-bind. 1 hit.
PF01108. Tissue_fac. 1 hit.
[Graphical view]
SMARTSM00060. FN3. 2 hits.
[Graphical view]
SUPFAMSSF49265. SSF49265. 2 hits.
PROSITEPS50853. FN3. 2 hits.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSIL10RB. mouse.
PROQ61190.
SOURCESearch...

Entry information

Entry nameI10R2_MOUSE
AccessionPrimary (citable) accession number: Q61190
Entry history
Integrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: November 1, 1996
Last modified: June 11, 2014
This is version 110 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot