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Protein

Melatonin receptor type 1A

Gene

Mtnr1a

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

High affinity receptor for melatonin. Likely to mediate the reproductive and circadian actions of melatonin. The activity of this receptor is mediated by pertussis toxin sensitive G proteins that inhibit adenylate cyclase activity (By similarity).By similarity

GO - Molecular functioni

  • hormone binding Source: MGI
  • melatonin receptor activity Source: MGI
  • organic cyclic compound binding Source: MGI

GO - Biological processi

  • circadian rhythm Source: MGI
  • positive regulation of cGMP biosynthetic process Source: MGI

Keywordsi

Molecular functionG-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

ReactomeiR-MMU-373076 Class A/1 (Rhodopsin-like receptors)
R-MMU-418594 G alpha (i) signalling events

Names & Taxonomyi

Protein namesi
Recommended name:
Melatonin receptor type 1A
Short name:
Mel-1A-R
Short name:
Mel1a receptor
Gene namesi
Name:Mtnr1a
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 8

Organism-specific databases

MGIiMGI:102967 Mtnr1a

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 32ExtracellularSequence analysisAdd BLAST32
Transmembranei33 – 53Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini54 – 66CytoplasmicSequence analysisAdd BLAST13
Transmembranei67 – 87Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini88 – 105ExtracellularSequence analysisAdd BLAST18
Transmembranei106 – 126Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini127 – 145CytoplasmicSequence analysisAdd BLAST19
Transmembranei146 – 166Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini167 – 190ExtracellularSequence analysisAdd BLAST24
Transmembranei191 – 211Helical; Name=5Sequence analysisAdd BLAST21
Topological domaini212 – 243CytoplasmicSequence analysisAdd BLAST32
Transmembranei244 – 264Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini265 – 277ExtracellularSequence analysisAdd BLAST13
Transmembranei278 – 298Helical; Name=7Sequence analysisAdd BLAST21
Topological domaini299 – 353CytoplasmicSequence analysisAdd BLAST55

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000698631 – 353Melatonin receptor type 1AAdd BLAST353

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi4N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi10N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi103 ↔ 180PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ61184
PRIDEiQ61184

PTM databases

iPTMnetiQ61184

Expressioni

Gene expression databases

BgeeiENSMUSG00000054764
CleanExiMM_MTNR1A
ExpressionAtlasiQ61184 baseline and differential
GenevisibleiQ61184 MM

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000069872

Structurei

3D structure databases

ProteinModelPortaliQ61184
SMRiQ61184
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IHFY Eukaryota
ENOG4111ZZV LUCA
GeneTreeiENSGT00440000033318
HOGENOMiHOG000037953
HOVERGENiHBG052528
InParanoidiQ61184
KOiK04285
OMAiHDVRNFV
OrthoDBiEOG091G0GO0
PhylomeDBiQ61184
TreeFamiTF331693

Family and domain databases

InterProiView protein in InterPro
IPR000276 GPCR_Rhodpsn
IPR017452 GPCR_Rhodpsn_7TM
IPR002278 Mel_1A/1B_rcpt
IPR027459 Mel_rcpt_1
IPR000025 Melatonin_rcpt
PANTHERiPTHR43962 PTHR43962, 1 hit
PfamiView protein in Pfam
PF00001 7tm_1, 1 hit
PRINTSiPR00237 GPCRRHODOPSN
PR01149 MELATONIN1AR
PR00857 MELATONINR
SMARTiView protein in SMART
SM01381 7TM_GPCR_Srsx, 1 hit
PROSITEiView protein in PROSITE
PS00237 G_PROTEIN_RECEP_F1_1, 1 hit
PS50262 G_PROTEIN_RECEP_F1_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q61184-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKGNVSELLN ATQQAPGGGE GGRPRPSWLA STLAFILIFT IVVDILGNLL
60 70 80 90 100
VILSVYRNKK LRNSGNIFVV SLAVADLVVA VYPYPLVLTS ILNNGWNLGY
110 120 130 140 150
LHCQVSAFLM GLSVIGSIFN ITGIAMNRYC YICHSLKYDK IYSNKNSLCY
160 170 180 190 200
VFLIWMLTLI AIMPNLQTGT LQYDPRIYSC TFTQSVSSAY TIAVVVFHFI
210 220 230 240 250
VPMIIVIFCY LRIWVLVLQV RRRVKPDNKP KLKPQDFRNF VTMFVVFVLF
260 270 280 290 300
AICWAPLNLI GLIVASDPAT MVPRIPEWLF VASYYLAYFN SCLNAIIYGL
310 320 330 340 350
LNQNFRKEYK KIIVSLCTAK MFFVESSNEE ADKIKCKPSP LIPNNNLIKV

DSV
Length:353
Mass (Da):39,837
Last modified:November 1, 1997 - v1
Checksum:i0975C2FD41B54C74
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U52222 mRNA Translation: AAB08755.1
CCDSiCCDS22273.1
RefSeqiNP_032665.1, NM_008639.2
UniGeneiMm.5133

Genome annotation databases

EnsembliENSMUST00000067984; ENSMUSP00000069872; ENSMUSG00000054764
GeneIDi17773
KEGGimmu:17773
UCSCiuc009loq.1 mouse

Similar proteinsi

Entry informationi

Entry nameiMTR1A_MOUSE
AccessioniPrimary (citable) accession number: Q61184
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1997
Last modified: April 25, 2018
This is version 130 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health