Reviewed, UniProtKB/Swiss-Prot Q61184 (MTR1A_MOUSE)

Names and origin

Protein names

Recommended name:
    Melatonin receptor type 1A
Alternative name(s):
    Mel-1A-R
    Mel1a melatonin receptor

Gene names

Name:

Mtnr1a

Organism

Mus musculus (Mouse)

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus

Protein attributes

Sequence length	353 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Function	High affinity receptor for melatonin. Likely to mediates the reproductive and circadian actions of melatonin. The activity of this receptor is mediated by pertussis toxin sensitive G proteins that inhibit adenylate cyclase activity By similarity.
Subcellular location	Cell membrane; Multi-pass membrane protein.
Sequence similarities	Belongs to the G-protein coupled receptor 1 family.

Ontologies

Keywords
Cellular component	Cell membrane Membrane
Domain	Transmembrane
Molecular function	G-protein coupled receptor Receptor Transducer
PTM	Disulfide bond Glycoprotein
Gene Ontology (GO)
Biological process	G-protein coupled receptor protein signaling pathway Inferred from electronic annotation. Source: UniProtKB-KW circadian rhythm Traceable author statement. Source: MGI
Cellular component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW plasma membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	melatonin receptor activity Traceable author statement. Source: MGI
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 353	353	Melatonin receptor type 1A		PRO_0000069863
Regions
	Topological domain	1 – 32	32	Extracellular Potential
	Transmembrane	33 – 53	21	1 Potential
	Topological domain	54 – 66	13	Cytoplasmic Potential
	Transmembrane	67 – 87	21	2 Potential
	Topological domain	88 – 105	18	Extracellular Potential
	Transmembrane	106 – 126	21	3 Potential
	Topological domain	127 – 145	19	Cytoplasmic Potential
	Transmembrane	146 – 166	21	4 Potential
	Topological domain	167 – 190	24	Extracellular Potential
	Transmembrane	191 – 211	21	5 Potential
	Topological domain	212 – 243	32	Cytoplasmic Potential
	Transmembrane	244 – 264	21	6 Potential
	Topological domain	265 – 277	13	Extracellular Potential
	Transmembrane	278 – 298	21	7 Potential
	Topological domain	299 – 353	55	Cytoplasmic Potential
Amino acid modifications
	Glycosylation	4	1	N-linked (GlcNAc...) Potential
	Glycosylation	10	1	N-linked (GlcNAc...) Potential
	Disulfide bond	103 ↔ 180		By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q61184-1 [UniParc]. Last modified November 1, 1997. Version 1. Checksum: 0975C2FD41B54C74	FASTA	353	39,837
	10 20 30 40 50 60 MKGNVSELLN ATQQAPGGGE GGRPRPSWLA STLAFILIFT IVVDILGNLL VILSVYRNKK 70 80 90 100 110 120 LRNSGNIFVV SLAVADLVVA VYPYPLVLTS ILNNGWNLGY LHCQVSAFLM GLSVIGSIFN 130 140 150 160 170 180 ITGIAMNRYC YICHSLKYDK IYSNKNSLCY VFLIWMLTLI AIMPNLQTGT LQYDPRIYSC 190 200 210 220 230 240 TFTQSVSSAY TIAVVVFHFI VPMIIVIFCY LRIWVLVLQV RRRVKPDNKP KLKPQDFRNF 250 260 270 280 290 300 VTMFVVFVLF AICWAPLNLI GLIVASDPAT MVPRIPEWLF VASYYLAYFN SCLNAIIYGL 310 320 330 340 350 LNQNFRKEYK KIIVSLCTAK MFFVESSNEE ADKIKCKPSP LIPNNNLIKV DSV

References

[1]	"Structure, characterization, and expression of the gene encoding the mouse Mel1a melatonin receptor." Roca A.L., Godson C., Weaver D.R., Reppert S.M. Endocrinology 137:3469-3477(1996) [PubMed: 8754776] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Strain: BALB/c.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBLGenBankDDBJ	U52222 mRNA. Translation: AAB08755.1.
IPI	IPI00117937.
RefSeq	NP_032665.1.
UniGene	Mm.5133
3D structure databases
ModBase	Search...
Protein family/group databases
GPCRDB	Search...
Proteomic databases
PRIDE	Q61184.
Genome annotation databases
Ensembl	ENSMUSG00000054764. Mus musculus. [Contig view]
GeneID	17773.
KEGG	mmu:17773.
Organism-specific databases
MGI	MGI:102967. Mtnr1a.
Phylogenomic databases
HOGENOM	Q61184.
HOVERGEN	Q61184.
OMA	Q61184. YMAYFNS.
Gene expression databases
ArrayExpress	Q61184.
Bgee	Q61184.
CleanEx	MM_MTNR1A.
GermOnline	ENSMUSG00000054764. Mus musculus.
Family and domain databases
InterPro	IPR000276. 7TM_GPCR_Rhodpsn. IPR017452. GPCR_Rhodpsn_supfam. IPR002278. Mel_1A_rcpt. IPR000025. Melatonin_rcpt. [Graphical view]
Pfam	PF00001. 7tm_1. 1 hit. [Graphical view]
PRINTS	PR00237. GPCRRHODOPSN. PR01149. MELATONIN1AR. PR00857. MELATONINR.
PROSITE	PS00237. G_PROTEIN_RECEP_F1_1. 1 hit. PS50262. G_PROTEIN_RECEP_F1_2. 1 hit. [Graphical view]
ProtoNet	Search...
Other Resources
NextBio	292495.
SOURCE	Search...

Entry information

Entry name

MTR1A_MOUSE

Accession

Primary (citable) accession number: Q61184

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1997
Last sequence update:	November 1, 1997
Last modified:	June 16, 2009
This is version 63 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)