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Protein

Melatonin receptor type 1A

Gene

Mtnr1a

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

High affinity receptor for melatonin. Likely to mediates the reproductive and circadian actions of melatonin. The activity of this receptor is mediated by pertussis toxin sensitive G proteins that inhibit adenylate cyclase activity (By similarity).By similarity

GO - Molecular functioni

  • hormone binding Source: MGI
  • melatonin receptor activity Source: MGI
  • organic cyclic compound binding Source: MGI

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

ReactomeiR-MMU-373076. Class A/1 (Rhodopsin-like receptors).
R-MMU-418594. G alpha (i) signalling events.

Names & Taxonomyi

Protein namesi
Recommended name:
Melatonin receptor type 1A
Short name:
Mel-1A-R
Short name:
Mel1a receptor
Gene namesi
Name:Mtnr1a
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 8

Organism-specific databases

MGIiMGI:102967. Mtnr1a.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 3232ExtracellularSequence analysisAdd
BLAST
Transmembranei33 – 5321Helical; Name=1Sequence analysisAdd
BLAST
Topological domaini54 – 6613CytoplasmicSequence analysisAdd
BLAST
Transmembranei67 – 8721Helical; Name=2Sequence analysisAdd
BLAST
Topological domaini88 – 10518ExtracellularSequence analysisAdd
BLAST
Transmembranei106 – 12621Helical; Name=3Sequence analysisAdd
BLAST
Topological domaini127 – 14519CytoplasmicSequence analysisAdd
BLAST
Transmembranei146 – 16621Helical; Name=4Sequence analysisAdd
BLAST
Topological domaini167 – 19024ExtracellularSequence analysisAdd
BLAST
Transmembranei191 – 21121Helical; Name=5Sequence analysisAdd
BLAST
Topological domaini212 – 24332CytoplasmicSequence analysisAdd
BLAST
Transmembranei244 – 26421Helical; Name=6Sequence analysisAdd
BLAST
Topological domaini265 – 27713ExtracellularSequence analysisAdd
BLAST
Transmembranei278 – 29821Helical; Name=7Sequence analysisAdd
BLAST
Topological domaini299 – 35355CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 353353Melatonin receptor type 1APRO_0000069863Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi4 – 41N-linked (GlcNAc...)Sequence analysis
Glycosylationi10 – 101N-linked (GlcNAc...)Sequence analysis
Disulfide bondi103 ↔ 180PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ61184.
PRIDEiQ61184.

Expressioni

Gene expression databases

BgeeiQ61184.
CleanExiMM_MTNR1A.
ExpressionAtlasiQ61184. baseline and differential.
GenevisibleiQ61184. MM.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000069872.

Structurei

3D structure databases

ProteinModelPortaliQ61184.
SMRiQ61184. Positions 42-315.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IHFY. Eukaryota.
ENOG4111ZZV. LUCA.
GeneTreeiENSGT00440000033318.
HOGENOMiHOG000037953.
HOVERGENiHBG052528.
InParanoidiQ61184.
KOiK04285.
OMAiHFLVPMI.
OrthoDBiEOG7MD4Q5.
PhylomeDBiQ61184.
TreeFamiTF331693.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR002278. Mel_1A_rcpt.
IPR000025. Melatonin_rcpt.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR01149. MELATONIN1AR.
PR00857. MELATONINR.
SMARTiSM01381. 7TM_GPCR_Srsx. 1 hit.
[Graphical view]
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q61184-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKGNVSELLN ATQQAPGGGE GGRPRPSWLA STLAFILIFT IVVDILGNLL
60 70 80 90 100
VILSVYRNKK LRNSGNIFVV SLAVADLVVA VYPYPLVLTS ILNNGWNLGY
110 120 130 140 150
LHCQVSAFLM GLSVIGSIFN ITGIAMNRYC YICHSLKYDK IYSNKNSLCY
160 170 180 190 200
VFLIWMLTLI AIMPNLQTGT LQYDPRIYSC TFTQSVSSAY TIAVVVFHFI
210 220 230 240 250
VPMIIVIFCY LRIWVLVLQV RRRVKPDNKP KLKPQDFRNF VTMFVVFVLF
260 270 280 290 300
AICWAPLNLI GLIVASDPAT MVPRIPEWLF VASYYLAYFN SCLNAIIYGL
310 320 330 340 350
LNQNFRKEYK KIIVSLCTAK MFFVESSNEE ADKIKCKPSP LIPNNNLIKV

DSV
Length:353
Mass (Da):39,837
Last modified:November 1, 1997 - v1
Checksum:i0975C2FD41B54C74
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U52222 mRNA. Translation: AAB08755.1.
CCDSiCCDS22273.1.
RefSeqiNP_032665.1. NM_008639.2.
UniGeneiMm.5133.

Genome annotation databases

EnsembliENSMUST00000067984; ENSMUSP00000069872; ENSMUSG00000054764.
GeneIDi17773.
KEGGimmu:17773.
UCSCiuc009loq.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U52222 mRNA. Translation: AAB08755.1.
CCDSiCCDS22273.1.
RefSeqiNP_032665.1. NM_008639.2.
UniGeneiMm.5133.

3D structure databases

ProteinModelPortaliQ61184.
SMRiQ61184. Positions 42-315.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000069872.

Protein family/group databases

GPCRDBiSearch...

Proteomic databases

PaxDbiQ61184.
PRIDEiQ61184.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000067984; ENSMUSP00000069872; ENSMUSG00000054764.
GeneIDi17773.
KEGGimmu:17773.
UCSCiuc009loq.1. mouse.

Organism-specific databases

CTDi4543.
MGIiMGI:102967. Mtnr1a.

Phylogenomic databases

eggNOGiENOG410IHFY. Eukaryota.
ENOG4111ZZV. LUCA.
GeneTreeiENSGT00440000033318.
HOGENOMiHOG000037953.
HOVERGENiHBG052528.
InParanoidiQ61184.
KOiK04285.
OMAiHFLVPMI.
OrthoDBiEOG7MD4Q5.
PhylomeDBiQ61184.
TreeFamiTF331693.

Enzyme and pathway databases

ReactomeiR-MMU-373076. Class A/1 (Rhodopsin-like receptors).
R-MMU-418594. G alpha (i) signalling events.

Miscellaneous databases

PROiQ61184.
SOURCEiSearch...

Gene expression databases

BgeeiQ61184.
CleanExiMM_MTNR1A.
ExpressionAtlasiQ61184. baseline and differential.
GenevisibleiQ61184. MM.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR002278. Mel_1A_rcpt.
IPR000025. Melatonin_rcpt.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR01149. MELATONIN1AR.
PR00857. MELATONINR.
SMARTiSM01381. 7TM_GPCR_Srsx. 1 hit.
[Graphical view]
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Structure, characterization, and expression of the gene encoding the mouse Mel1a melatonin receptor."
    Roca A.L., Godson C., Weaver D.R., Reppert S.M.
    Endocrinology 137:3469-3477(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: BALB/cJ.

Entry informationi

Entry nameiMTR1A_MOUSE
AccessioniPrimary (citable) accession number: Q61184
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1997
Last modified: July 6, 2016
This is version 119 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.