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Q61179

- IRF9_MOUSE

UniProt

Q61179 - IRF9_MOUSE

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Protein
Interferon regulatory factor 9
Gene
Irf9, Isgf3g
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Transcription factor that mediates signaling by type I IFNs (IFN-alpha and IFN-beta). Following type I IFN binding to cell surface receptors, Jak kinases (TYK2 and JAK1) are activated, leading to tyrosine phosphorylation of STAT1 and STAT2. IRF9/ISGF3G associateswith the phosphorylated STAT1:STAT2 dimer to form a complex termed ISGF3 transcription factor, that enters the nucleus. ISGF3 binds to the IFN stimulated response element (ISRE) to activate the transcription of interferon stimulated genes, which drive the cell in an antiviral state.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi9 – 116108IRF tryptophan pentad repeat
Add
BLAST

GO - Molecular functioni

  1. protein binding Source: IntAct
  2. regulatory region DNA binding Source: InterPro
  3. sequence-specific DNA binding transcription factor activity Source: InterPro

GO - Biological processi

  1. transcription, DNA-templated Source: UniProtKB-KW
  2. type I interferon biosynthetic process Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

Activator

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Enzyme and pathway databases

ReactomeiREACT_198622. Interferon alpha/beta signaling.
REACT_198660. Interferon gamma signaling.

Names & Taxonomyi

Protein namesi
Recommended name:
Interferon regulatory factor 9
Short name:
IRF-9
Alternative name(s):
IFN-alpha-responsive transcription factor subunit
ISGF3 p48 subunit
Interferon-stimulated gene factor 3 gamma
Short name:
ISGF-3 gamma
Transcriptional regulator ISGF3 subunit gamma
Gene namesi
Name:Irf9
Synonyms:Isgf3g
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 14

Organism-specific databases

MGIiMGI:107587. Irf9.

Subcellular locationi

GO - Cellular componenti

  1. nucleus Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 399399Interferon regulatory factor 9
PRO_0000154568Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei393 – 3931Phosphoserine1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ61179.
PRIDEiQ61179.

PTM databases

PhosphoSiteiQ61179.

Expressioni

Inductioni

By IFN-alpha and IFN-beta. Upon stimulation the regulatory phosphorylated alpha and beta subunits assemble with the gamma subunit and translocate from the cytoplasm to the nucleus.

Gene expression databases

ArrayExpressiQ61179.
BgeeiQ61179.
CleanExiMM_IRF9.
GenevestigatoriQ61179.

Interactioni

Subunit structurei

Interacts with STAT2 in the cytoplasm. Forms the interferon-stimulated gene factor 3 complex (ISGF3) with the heterodimer STAT1:STAT2; upon stimulation.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
Stat2Q9QXJ29EBI-646653,EBI-646643

Protein-protein interaction databases

BioGridi200811. 8 interactions.
IntActiQ61179. 2 interactions.
STRINGi10090.ENSMUSP00000120525.

Structurei

3D structure databases

ProteinModelPortaliQ61179.
SMRiQ61179. Positions 11-116, 204-379.

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi165 – 1706Poly-Gly

Sequence similaritiesi

Belongs to the IRF family.

Phylogenomic databases

eggNOGiNOG43166.
GeneTreeiENSGT00740000114956.
HOGENOMiHOG000010107.
HOVERGENiHBG003072.
InParanoidiQ61179.
KOiK04693.
PhylomeDBiQ61179.

Family and domain databases

Gene3Di1.10.10.10. 1 hit.
2.60.200.10. 1 hit.
InterProiIPR019817. Interferon_reg_fac_CS.
IPR001346. Interferon_reg_fact_DNA-bd_dom.
IPR019471. Interferon_reg_factor-3.
IPR017855. SMAD_dom-like.
IPR008984. SMAD_FHA_domain.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PfamiPF00605. IRF. 1 hit.
PF10401. IRF-3. 1 hit.
[Graphical view]
PRINTSiPR00267. INTFRNREGFCT.
SMARTiSM00348. IRF. 1 hit.
[Graphical view]
SUPFAMiSSF49879. SSF49879. 1 hit.
PROSITEiPS00601. IRF_1. 1 hit.
PS51507. IRF_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q61179-1 [UniParc]FASTAAdd to Basket

« Hide

MASGKVRCTR KLRSWIVEQV ESGHFPGVCW DDAAKTMFRI PWKHAGKQDF    50
REDQDAAIFK AWALFKEKHK DGDIGHPAVW KTRLRCALNK SSEFEEVPER 100
GRMDVAEPYK VYRILPAGTL PNQPRNQKSP CKRSISCVSP EREENMENGR 150
TNGVVNHSDS GSNIGGGGNG SNRSDSNSNC NSELEEGAGT TEATIREDPV 200
FLEHQLPLNS DYSLLLTFIY GGRVVGKTQV HSLDCRLVAE RSDSESSMEQ 250
VEFPKPDPLE PTQHLLNQLD RGVLVASNSR GLFVQRLCPI PISWNAPEAP 300
PGPGPHLLPS NKCVELFKTT YFCRDLAQYF QGQGPPPKFQ ATLHFWEESP 350
GSSHSQENLI TVQMEQAFAR HLLEKIPEEE KAALFLLQHT EQSPSALGH 399
Length:399
Mass (Da):44,610
Last modified:November 1, 1997 - v1
Checksum:i92F9481ACEB669BD
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U51992 mRNA. Translation: AAC52494.1.
BC005435 mRNA. Translation: AAH05435.1.
BC012968 mRNA. Translation: AAH12968.1.
CCDSiCCDS27119.1.
PIRiJC4592.
RefSeqiNP_001152889.1. NM_001159417.1.
NP_001152890.1. NM_001159418.1.
NP_032420.1. NM_008394.3.
UniGeneiMm.2032.

Genome annotation databases

EnsembliENSMUST00000130697; ENSMUSP00000120359; ENSMUSG00000002325.
GeneIDi16391.
KEGGimmu:16391.
UCSCiuc007tzl.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U51992 mRNA. Translation: AAC52494.1 .
BC005435 mRNA. Translation: AAH05435.1 .
BC012968 mRNA. Translation: AAH12968.1 .
CCDSi CCDS27119.1.
PIRi JC4592.
RefSeqi NP_001152889.1. NM_001159417.1.
NP_001152890.1. NM_001159418.1.
NP_032420.1. NM_008394.3.
UniGenei Mm.2032.

3D structure databases

ProteinModelPortali Q61179.
SMRi Q61179. Positions 11-116, 204-379.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 200811. 8 interactions.
IntActi Q61179. 2 interactions.
STRINGi 10090.ENSMUSP00000120525.

PTM databases

PhosphoSitei Q61179.

Proteomic databases

PaxDbi Q61179.
PRIDEi Q61179.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000130697 ; ENSMUSP00000120359 ; ENSMUSG00000002325 .
GeneIDi 16391.
KEGGi mmu:16391.
UCSCi uc007tzl.2. mouse.

Organism-specific databases

CTDi 10379.
MGIi MGI:107587. Irf9.

Phylogenomic databases

eggNOGi NOG43166.
GeneTreei ENSGT00740000114956.
HOGENOMi HOG000010107.
HOVERGENi HBG003072.
InParanoidi Q61179.
KOi K04693.
PhylomeDBi Q61179.

Enzyme and pathway databases

Reactomei REACT_198622. Interferon alpha/beta signaling.
REACT_198660. Interferon gamma signaling.

Miscellaneous databases

ChiTaRSi IRF9. mouse.
NextBioi 289533.
PROi Q61179.
SOURCEi Search...

Gene expression databases

ArrayExpressi Q61179.
Bgeei Q61179.
CleanExi MM_IRF9.
Genevestigatori Q61179.

Family and domain databases

Gene3Di 1.10.10.10. 1 hit.
2.60.200.10. 1 hit.
InterProi IPR019817. Interferon_reg_fac_CS.
IPR001346. Interferon_reg_fact_DNA-bd_dom.
IPR019471. Interferon_reg_factor-3.
IPR017855. SMAD_dom-like.
IPR008984. SMAD_FHA_domain.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view ]
Pfami PF00605. IRF. 1 hit.
PF10401. IRF-3. 1 hit.
[Graphical view ]
PRINTSi PR00267. INTFRNREGFCT.
SMARTi SM00348. IRF. 1 hit.
[Graphical view ]
SUPFAMi SSF49879. SSF49879. 1 hit.
PROSITEi PS00601. IRF_1. 1 hit.
PS51507. IRF_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Structure of mouse interferon stimulated gene factor 3 gamma (ISGF3 gamma/p48) cDNA and chromosomal localization of the gene."
    Suhara W., Yoneyama M., Yonekawa H., Takashi F.
    J. Biochem. 119:231-234(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: FVB/N.
    Tissue: Mammary gland.
  3. "Possible involvement of the transcription factor ISGF3 gamma in virus-induced expression of the IFN-beta gene."
    Kawakami T., Matsumoto M., Sato M., Harada H., Taniguchi T., Kitagawa M.
    FEBS Lett. 358:225-229(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1-87.
  4. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-393, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Liver.
  5. "Multiple functions of the IKK-related kinase IKKepsilon in interferon-mediated antiviral immunity."
    Tenoever B.R., Ng S.L., Chua M.A., McWhirter S.M., Garcia-Sastre A., Maniatis T.
    Science 315:1274-1278(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION IN THE ISGF3 COMPLEX.

Entry informationi

Entry nameiIRF9_MOUSE
AccessioniPrimary (citable) accession number: Q61179
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1997
Last modified: September 3, 2014
This is version 118 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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