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Q61176

- ARGI1_MOUSE

UniProt

Q61176 - ARGI1_MOUSE

Protein

Arginase-1

Gene

Arg1

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 121 (01 Oct 2014)
      Sequence version 1 (01 Nov 1997)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    L-arginine + H2O = L-ornithine + urea.

    Cofactori

    Binds 2 manganese ions per subunit.PROSITE-ProRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi101 – 1011Manganese 1PROSITE-ProRule annotation
    Metal bindingi124 – 1241Manganese 1PROSITE-ProRule annotation
    Metal bindingi124 – 1241Manganese 2PROSITE-ProRule annotation
    Metal bindingi126 – 1261Manganese 2PROSITE-ProRule annotation
    Metal bindingi128 – 1281Manganese 1PROSITE-ProRule annotation
    Binding sitei183 – 1831SubstrateBy similarity
    Metal bindingi232 – 2321Manganese 1PROSITE-ProRule annotation
    Metal bindingi232 – 2321Manganese 2PROSITE-ProRule annotation
    Metal bindingi234 – 2341Manganese 2PROSITE-ProRule annotation

    GO - Molecular functioni

    1. arginase activity Source: MGI
    2. manganese ion binding Source: Ensembl

    GO - Biological processi

    1. arginine metabolic process Source: UniProtKB-KW
    2. cellular response to dexamethasone stimulus Source: Ensembl
    3. cellular response to glucagon stimulus Source: Ensembl
    4. cellular response to hydrogen peroxide Source: Ensembl
    5. cellular response to interleukin-4 Source: Ensembl
    6. cellular response to lipopolysaccharide Source: Ensembl
    7. cellular response to transforming growth factor beta stimulus Source: Ensembl
    8. collagen biosynthetic process Source: Ensembl
    9. liver development Source: Ensembl
    10. lung development Source: Ensembl
    11. mammary gland involution Source: Ensembl
    12. maternal process involved in female pregnancy Source: Ensembl
    13. positive regulation of endothelial cell proliferation Source: Ensembl
    14. protein homotrimerization Source: Ensembl
    15. regulation of L-arginine import Source: Ensembl
    16. response to amine Source: Ensembl
    17. response to amino acid Source: Ensembl
    18. response to axon injury Source: Ensembl
    19. response to cadmium ion Source: Ensembl
    20. response to drug Source: Ensembl
    21. response to herbicide Source: Ensembl
    22. response to manganese ion Source: Ensembl
    23. response to methylmercury Source: Ensembl
    24. response to selenium ion Source: Ensembl
    25. response to vitamin A Source: Ensembl
    26. response to vitamin E Source: Ensembl
    27. response to zinc ion Source: Ensembl
    28. urea cycle Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Hydrolase

    Keywords - Biological processi

    Arginine metabolism, Urea cycle

    Keywords - Ligandi

    Manganese, Metal-binding

    Enzyme and pathway databases

    SABIO-RKQ61176.
    UniPathwayiUPA00158; UER00270.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Arginase-1 (EC:3.5.3.1)
    Alternative name(s):
    Liver-type arginase
    Type I arginase
    Gene namesi
    Name:Arg1
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 10

    Organism-specific databases

    MGIiMGI:88070. Arg1.

    Subcellular locationi

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell
    2. extracellular space Source: Ensembl
    3. neuronal cell body Source: Ensembl
    4. neuron projection Source: Ensembl

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 323323Arginase-1PRO_0000173694Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei7 – 71Phosphoserine1 Publication
    Modified residuei17 – 171N6-succinyllysine1 Publication
    Modified residuei72 – 721Phosphoserine1 Publication
    Modified residuei75 – 751N6-succinyllysine1 Publication
    Modified residuei281 – 2811Phosphothreonine1 Publication

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    MaxQBiQ61176.
    PaxDbiQ61176.
    PRIDEiQ61176.

    2D gel databases

    SWISS-2DPAGEQ61176.

    PTM databases

    PhosphoSiteiQ61176.

    Expressioni

    Gene expression databases

    BgeeiQ61176.
    CleanExiMM_ARG1.
    GenevestigatoriQ61176.

    Interactioni

    Subunit structurei

    Homotrimer.By similarity

    Protein-protein interaction databases

    BioGridi198190. 1 interaction.
    IntActiQ61176. 4 interactions.
    MINTiMINT-1854942.

    Structurei

    3D structure databases

    ProteinModelPortaliQ61176.
    SMRiQ61176. Positions 6-313.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni126 – 1305Substrate bindingBy similarity
    Regioni137 – 1393Substrate bindingBy similarity

    Sequence similaritiesi

    Belongs to the arginase family.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiCOG0010.
    GeneTreeiENSGT00530000063082.
    HOGENOMiHOG000204319.
    HOVERGENiHBG003030.
    InParanoidiQ61176.
    KOiK01476.
    OMAiKEQECDV.
    OrthoDBiEOG747PJ5.
    PhylomeDBiQ61176.
    TreeFamiTF300034.

    Family and domain databases

    Gene3Di3.40.800.10. 1 hit.
    InterProiIPR014033. Arginase.
    IPR006035. Ureohydrolase.
    IPR023696. Ureohydrolase_domain.
    IPR020855. Ureohydrolase_Mn_BS.
    [Graphical view]
    PANTHERiPTHR11358. PTHR11358. 1 hit.
    PfamiPF00491. Arginase. 1 hit.
    [Graphical view]
    PIRSFiPIRSF036979. Arginase. 1 hit.
    PRINTSiPR00116. ARGINASE.
    TIGRFAMsiTIGR01229. rocF_arginase. 1 hit.
    PROSITEiPS01053. ARGINASE_1. 1 hit.
    PS51409. ARGINASE_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q61176-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSSKPKSLEI IGAPFSKGQP RGGVEKGPAA LRKAGLLEKL KETEYDVRDH    50
    GDLAFVDVPN DSSFQIVKNP RSVGKANEEL AGVVAEVQKN GRVSVVLGGD 100
    HSLAVGSISG HARVHPDLCV IWVDAHTDIN TPLTTSSGNL HGQPVSFLLK 150
    ELKGKFPDVP GFSWVTPCIS AKDIVYIGLR DVDPGEHYII KTLGIKYFSM 200
    TEVDKLGIGK VMEETFSYLL GRKKRPIHLS FDVDGLDPAF TPATGTPVLG 250
    GLSYREGLYI TEEIYKTGLL SGLDIMEVNP TLGKTAEEVK STVNTAVALT 300
    LACFGTQREG NHKPGTDYLK PPK 323
    Length:323
    Mass (Da):34,808
    Last modified:November 1, 1997 - v1
    Checksum:i6D0231978AC1B977
    GO

    Sequence cautioni

    The sequence BAE28901.1 differs from that shown. Reason: Erroneous initiation.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti109 – 1091S → T in BAE28901. (PubMed:16141072)Curated
    Sequence conflicti306 – 3061T → A in CAJ18381. 1 PublicationCurated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U51805 mRNA. Translation: AAA98611.1.
    AK149471 mRNA. Translation: BAE28901.1. Different initiation.
    AK171417 mRNA. Translation: BAE42440.1.
    CT010173 mRNA. Translation: CAJ18381.1.
    BC013341 mRNA. Translation: AAH13341.1.
    BC050005 mRNA. Translation: AAH50005.2.
    CCDSiCCDS48523.1.
    RefSeqiNP_031508.1. NM_007482.3.
    UniGeneiMm.154144.

    Genome annotation databases

    EnsembliENSMUST00000020161; ENSMUSP00000020161; ENSMUSG00000019987.
    GeneIDi11846.
    KEGGimmu:11846.
    UCSCiuc007erg.2. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U51805 mRNA. Translation: AAA98611.1 .
    AK149471 mRNA. Translation: BAE28901.1 . Different initiation.
    AK171417 mRNA. Translation: BAE42440.1 .
    CT010173 mRNA. Translation: CAJ18381.1 .
    BC013341 mRNA. Translation: AAH13341.1 .
    BC050005 mRNA. Translation: AAH50005.2 .
    CCDSi CCDS48523.1.
    RefSeqi NP_031508.1. NM_007482.3.
    UniGenei Mm.154144.

    3D structure databases

    ProteinModelPortali Q61176.
    SMRi Q61176. Positions 6-313.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 198190. 1 interaction.
    IntActi Q61176. 4 interactions.
    MINTi MINT-1854942.

    PTM databases

    PhosphoSitei Q61176.

    2D gel databases

    SWISS-2DPAGE Q61176.

    Proteomic databases

    MaxQBi Q61176.
    PaxDbi Q61176.
    PRIDEi Q61176.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000020161 ; ENSMUSP00000020161 ; ENSMUSG00000019987 .
    GeneIDi 11846.
    KEGGi mmu:11846.
    UCSCi uc007erg.2. mouse.

    Organism-specific databases

    CTDi 383.
    MGIi MGI:88070. Arg1.

    Phylogenomic databases

    eggNOGi COG0010.
    GeneTreei ENSGT00530000063082.
    HOGENOMi HOG000204319.
    HOVERGENi HBG003030.
    InParanoidi Q61176.
    KOi K01476.
    OMAi KEQECDV.
    OrthoDBi EOG747PJ5.
    PhylomeDBi Q61176.
    TreeFami TF300034.

    Enzyme and pathway databases

    UniPathwayi UPA00158 ; UER00270 .
    SABIO-RK Q61176.

    Miscellaneous databases

    ChiTaRSi ARG1. mouse.
    NextBioi 279807.
    PROi Q61176.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q61176.
    CleanExi MM_ARG1.
    Genevestigatori Q61176.

    Family and domain databases

    Gene3Di 3.40.800.10. 1 hit.
    InterProi IPR014033. Arginase.
    IPR006035. Ureohydrolase.
    IPR023696. Ureohydrolase_domain.
    IPR020855. Ureohydrolase_Mn_BS.
    [Graphical view ]
    PANTHERi PTHR11358. PTHR11358. 1 hit.
    Pfami PF00491. Arginase. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF036979. Arginase. 1 hit.
    PRINTSi PR00116. ARGINASE.
    TIGRFAMsi TIGR01229. rocF_arginase. 1 hit.
    PROSITEi PS01053. ARGINASE_1. 1 hit.
    PS51409. ARGINASE_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Chieko H.
      Submitted (MAR-1996) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: C57BL/6 X CBA.
      Tissue: Liver.
    2. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6J.
      Tissue: Liver.
    3. "Cloning of mouse full open reading frames in Gateway(R) system entry vector (pDONR201)."
      Ebert L., Muenstermann E., Schatten R., Henze S., Bohn E., Mollenhauer J., Wiemann S., Schick M., Korn B.
      Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: FVB/N.
      Tissue: Liver and Mammary gland.
    5. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-7; SER-72 AND THR-281, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Liver.
    6. "SIRT5-mediated lysine desuccinylation impacts diverse metabolic pathways."
      Park J., Chen Y., Tishkoff D.X., Peng C., Tan M., Dai L., Xie Z., Zhang Y., Zwaans B.M., Skinner M.E., Lombard D.B., Zhao Y.
      Mol. Cell 50:919-930(2013) [PubMed] [Europe PMC] [Abstract]
      Cited for: SUCCINYLATION [LARGE SCALE ANALYSIS] AT LYS-17 AND LYS-75, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Liver.

    Entry informationi

    Entry nameiARGI1_MOUSE
    AccessioniPrimary (citable) accession number: Q61176
    Secondary accession number(s): Q3TB74
    , Q3UEL0, Q4FK78, Q80VI4
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1997
    Last sequence update: November 1, 1997
    Last modified: October 1, 2014
    This is version 121 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3