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Protein

Arginase-1

Gene

Arg1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Catalytic activityi

L-arginine + H2O = L-ornithine + urea.By similarity

Cofactori

Mn2+PROSITE-ProRule annotationNote: Binds 2 manganese ions per subunit.PROSITE-ProRule annotation

Pathwayi: urea cycle

This protein is involved in step 1 of the subpathway that synthesizes L-ornithine and urea from L-arginine.By similarity
Proteins known to be involved in this subpathway in this organism are:
  1. Arginase-2, mitochondrial (Arg2), Arginase-1 (Arg1), Arginase (Arg2)
This subpathway is part of the pathway urea cycle, which is itself part of Nitrogen metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes L-ornithine and urea from L-arginine, the pathway urea cycle and in Nitrogen metabolism.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi101Manganese 1PROSITE-ProRule annotation1
Metal bindingi124Manganese 1PROSITE-ProRule annotation1
Metal bindingi124Manganese 2PROSITE-ProRule annotation1
Metal bindingi126Manganese 2PROSITE-ProRule annotation1
Metal bindingi128Manganese 1PROSITE-ProRule annotation1
Binding sitei183SubstrateBy similarity1
Metal bindingi232Manganese 1PROSITE-ProRule annotation1
Metal bindingi232Manganese 2PROSITE-ProRule annotation1
Metal bindingi234Manganese 2PROSITE-ProRule annotation1
Binding sitei246SubstrateBy similarity1
Binding sitei277SubstrateBy similarity1

GO - Molecular functioni

  • arginase activity Source: MGI
  • manganese ion binding Source: Ensembl

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Arginine metabolism, Urea cycle

Keywords - Ligandi

Manganese, Metal-binding

Enzyme and pathway databases

BRENDAi3.5.3.1. 3474.
ReactomeiR-MMU-6798695. Neutrophil degranulation.
R-MMU-70635. Urea cycle.
SABIO-RKQ61176.
UniPathwayiUPA00158; UER00270.

Names & Taxonomyi

Protein namesi
Recommended name:
Arginase-1 (EC:3.5.3.1By similarity)
Alternative name(s):
Liver-type arginase
Type I arginase
Gene namesi
Name:Arg1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 10

Organism-specific databases

MGIiMGI:88070. Arg1.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001736941 – 323Arginase-1Add BLAST323

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei7PhosphoserineCombined sources1
Modified residuei17N6-succinyllysineCombined sources1
Modified residuei62PhosphoserineBy similarity1
Modified residuei72PhosphoserineCombined sources1
Modified residuei75N6-succinyllysineCombined sources1
Modified residuei163PhosphoserineCombined sources1
Modified residuei217PhosphoserineBy similarity1
Modified residuei281PhosphothreonineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ61176.
PaxDbiQ61176.
PeptideAtlasiQ61176.
PRIDEiQ61176.

2D gel databases

SWISS-2DPAGEQ61176.

PTM databases

iPTMnetiQ61176.
PhosphoSitePlusiQ61176.
SwissPalmiQ61176.

Expressioni

Gene expression databases

BgeeiENSMUSG00000019987.
CleanExiMM_ARG1.
GenevisibleiQ61176. MM.

Interactioni

Subunit structurei

Homotrimer.By similarity

Protein-protein interaction databases

BioGridi198190. 1 interactor.
IntActiQ61176. 4 interactors.
MINTiMINT-1854942.
STRINGi10090.ENSMUSP00000020161.

Structurei

3D structure databases

ProteinModelPortaliQ61176.
SMRiQ61176.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni126 – 130Substrate bindingBy similarity5
Regioni137 – 139Substrate bindingBy similarity3

Sequence similaritiesi

Belongs to the arginase family.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG2965. Eukaryota.
COG0010. LUCA.
GeneTreeiENSGT00530000063082.
HOGENOMiHOG000204319.
HOVERGENiHBG003030.
InParanoidiQ61176.
KOiK01476.
OMAiEQECDVK.
OrthoDBiEOG091G0A38.
PhylomeDBiQ61176.
TreeFamiTF300034.

Family and domain databases

Gene3Di3.40.800.10. 1 hit.
InterProiIPR014033. Arginase.
IPR006035. Ureohydrolase.
IPR023696. Ureohydrolase_domain.
IPR020855. Ureohydrolase_Mn_BS.
[Graphical view]
PfamiPF00491. Arginase. 1 hit.
[Graphical view]
PIRSFiPIRSF036979. Arginase. 1 hit.
PRINTSiPR00116. ARGINASE.
TIGRFAMsiTIGR01229. rocF_arginase. 1 hit.
PROSITEiPS01053. ARGINASE_1. 1 hit.
PS51409. ARGINASE_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q61176-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSSKPKSLEI IGAPFSKGQP RGGVEKGPAA LRKAGLLEKL KETEYDVRDH
60 70 80 90 100
GDLAFVDVPN DSSFQIVKNP RSVGKANEEL AGVVAEVQKN GRVSVVLGGD
110 120 130 140 150
HSLAVGSISG HARVHPDLCV IWVDAHTDIN TPLTTSSGNL HGQPVSFLLK
160 170 180 190 200
ELKGKFPDVP GFSWVTPCIS AKDIVYIGLR DVDPGEHYII KTLGIKYFSM
210 220 230 240 250
TEVDKLGIGK VMEETFSYLL GRKKRPIHLS FDVDGLDPAF TPATGTPVLG
260 270 280 290 300
GLSYREGLYI TEEIYKTGLL SGLDIMEVNP TLGKTAEEVK STVNTAVALT
310 320
LACFGTQREG NHKPGTDYLK PPK
Length:323
Mass (Da):34,808
Last modified:November 1, 1997 - v1
Checksum:i6D0231978AC1B977
GO

Sequence cautioni

The sequence BAE28901 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti109S → T in BAE28901 (PubMed:16141072).Curated1
Sequence conflicti306T → A in CAJ18381 (Ref. 3) Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U51805 mRNA. Translation: AAA98611.1.
AK149471 mRNA. Translation: BAE28901.1. Different initiation.
AK171417 mRNA. Translation: BAE42440.1.
CT010173 mRNA. Translation: CAJ18381.1.
BC013341 mRNA. Translation: AAH13341.1.
BC050005 mRNA. Translation: AAH50005.2.
CCDSiCCDS48523.1.
RefSeqiNP_031508.1. NM_007482.3.
UniGeneiMm.154144.

Genome annotation databases

EnsembliENSMUST00000020161; ENSMUSP00000020161; ENSMUSG00000019987.
GeneIDi11846.
KEGGimmu:11846.
UCSCiuc007erg.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U51805 mRNA. Translation: AAA98611.1.
AK149471 mRNA. Translation: BAE28901.1. Different initiation.
AK171417 mRNA. Translation: BAE42440.1.
CT010173 mRNA. Translation: CAJ18381.1.
BC013341 mRNA. Translation: AAH13341.1.
BC050005 mRNA. Translation: AAH50005.2.
CCDSiCCDS48523.1.
RefSeqiNP_031508.1. NM_007482.3.
UniGeneiMm.154144.

3D structure databases

ProteinModelPortaliQ61176.
SMRiQ61176.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi198190. 1 interactor.
IntActiQ61176. 4 interactors.
MINTiMINT-1854942.
STRINGi10090.ENSMUSP00000020161.

PTM databases

iPTMnetiQ61176.
PhosphoSitePlusiQ61176.
SwissPalmiQ61176.

2D gel databases

SWISS-2DPAGEQ61176.

Proteomic databases

MaxQBiQ61176.
PaxDbiQ61176.
PeptideAtlasiQ61176.
PRIDEiQ61176.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000020161; ENSMUSP00000020161; ENSMUSG00000019987.
GeneIDi11846.
KEGGimmu:11846.
UCSCiuc007erg.2. mouse.

Organism-specific databases

CTDi383.
MGIiMGI:88070. Arg1.

Phylogenomic databases

eggNOGiKOG2965. Eukaryota.
COG0010. LUCA.
GeneTreeiENSGT00530000063082.
HOGENOMiHOG000204319.
HOVERGENiHBG003030.
InParanoidiQ61176.
KOiK01476.
OMAiEQECDVK.
OrthoDBiEOG091G0A38.
PhylomeDBiQ61176.
TreeFamiTF300034.

Enzyme and pathway databases

UniPathwayiUPA00158; UER00270.
BRENDAi3.5.3.1. 3474.
ReactomeiR-MMU-6798695. Neutrophil degranulation.
R-MMU-70635. Urea cycle.
SABIO-RKQ61176.

Miscellaneous databases

ChiTaRSiArg1. mouse.
PROiQ61176.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000019987.
CleanExiMM_ARG1.
GenevisibleiQ61176. MM.

Family and domain databases

Gene3Di3.40.800.10. 1 hit.
InterProiIPR014033. Arginase.
IPR006035. Ureohydrolase.
IPR023696. Ureohydrolase_domain.
IPR020855. Ureohydrolase_Mn_BS.
[Graphical view]
PfamiPF00491. Arginase. 1 hit.
[Graphical view]
PIRSFiPIRSF036979. Arginase. 1 hit.
PRINTSiPR00116. ARGINASE.
TIGRFAMsiTIGR01229. rocF_arginase. 1 hit.
PROSITEiPS01053. ARGINASE_1. 1 hit.
PS51409. ARGINASE_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiARGI1_MOUSE
AccessioniPrimary (citable) accession number: Q61176
Secondary accession number(s): Q3TB74
, Q3UEL0, Q4FK78, Q80VI4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1997
Last modified: November 30, 2016
This is version 141 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.