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Q61169

- GATA6_MOUSE

UniProt

Q61169 - GATA6_MOUSE

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Protein
Transcription factor GATA-6
Gene
Gata6
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Transcriptional activator that regulates SEMA3C and PLXNA2. Involved in gene regulation specifically in the gastric epithelium By similarity.1 Publication

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri384 – 40825GATA-type 1
Add
BLAST
Zinc fingeri438 – 46225GATA-type 2
Add
BLAST

GO - Molecular functioni

  1. DNA binding Source: MGI
  2. RNA polymerase II core promoter sequence-specific DNA binding Source: MGI
  3. RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity Source: MGI
  4. RNA polymerase II repressing transcription factor binding Source: BHF-UCL
  5. chromatin binding Source: MGI
  6. protein binding Source: UniProtKB
  7. sequence-specific DNA binding Source: MGI
  8. sequence-specific DNA binding transcription factor activity Source: MGI
  9. transcription factor binding Source: MGI
  10. zinc ion binding Source: InterPro

GO - Biological processi

  1. Clara cell differentiation Source: MGI
  2. Type II pneumocyte differentiation Source: MGI
  3. cardiac muscle cell differentiation Source: BHF-UCL
  4. cardiac muscle hypertrophy in response to stress Source: MGI
  5. cardiac muscle tissue development Source: MGI
  6. cardiac vascular smooth muscle cell differentiation Source: Ensembl
  7. cellular response to BMP stimulus Source: MGI
  8. cellular response to gonadotropin stimulus Source: MGI
  9. cellular response to hypoxia Source: Ensembl
  10. endodermal cell differentiation Source: MGI
  11. endodermal cell fate determination Source: MGI
  12. epithelial cell differentiation Source: MGI
  13. in utero embryonic development Source: MGI
  14. intestinal epithelial cell differentiation Source: MGI
  15. liver development Source: MGI
  16. lung saccule development Source: MGI
  17. male gonad development Source: Ensembl
  18. negative regulation of apoptotic process Source: Ensembl
  19. negative regulation of transcription from RNA polymerase II promoter Source: Ensembl
  20. negative regulation of transforming growth factor beta1 production Source: Ensembl
  21. negative regulation of transforming growth factor beta2 production Source: Ensembl
  22. organ formation Source: MGI
  23. outflow tract septum morphogenesis Source: Ensembl
  24. pancreas development Source: MGI
  25. pancreatic A cell differentiation Source: MGI
  26. phospholipid metabolic process Source: MGI
  27. positive regulation of angiogenesis Source: Ensembl
  28. positive regulation of cardiac muscle cell proliferation Source: MGI
  29. positive regulation of cardioblast differentiation Source: BHF-UCL
  30. positive regulation of cell cycle arrest Source: Ensembl
  31. positive regulation of transcription from RNA polymerase II promoter Source: BHF-UCL
  32. positive regulation of transcription, DNA-templated Source: MGI
  33. regulation of gene expression Source: MGI
  34. response to drug Source: Ensembl
  35. response to estrogen Source: MGI
  36. tube morphogenesis Source: MGI
  37. type B pancreatic cell differentiation Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

Activator

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Enzyme and pathway databases

ReactomeiREACT_198649. Factors involved in megakaryocyte development and platelet production.

Names & Taxonomyi

Protein namesi
Recommended name:
Transcription factor GATA-6
Alternative name(s):
GATA-binding factor 6
Gene namesi
Name:Gata6
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 18

Organism-specific databases

MGIiMGI:107516. Gata6.

Subcellular locationi

Nucleus 1 Publication

GO - Cellular componenti

  1. nucleus Source: MGI
  2. transcription factor complex Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 589589Transcription factor GATA-6
PRO_0000083424Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei266 – 2661Phosphoserine By similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

PRIDEiQ61169.

PTM databases

PhosphoSiteiQ61169.

Expressioni

Tissue specificityi

Expressed in myocardium, vascular smooth muscle, gut epithelium, and osteoclasts.

Gene expression databases

ArrayExpressiQ61169.
BgeeiQ61169.
CleanExiMM_GATA6.
GenevestigatoriQ61169.

Interactioni

Subunit structurei

Interacts with LMCD1.1 Publication

Protein-protein interaction databases

BioGridi199843. 12 interactions.
IntActiQ61169. 2 interactions.
MINTiMINT-1782188.
STRINGi10090.ENSMUSP00000041774.

Structurei

3D structure databases

ProteinModelPortaliQ61169.
SMRiQ61169. Positions 380-488.

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi173 – 18311Poly-Ala
Add
BLAST
Compositional biasi322 – 3287Poly-His
Compositional biasi443 – 4475Poly-Thr

Domaini

The GATA-type zinc fingers mediate interaction with LMCD1.1 Publication

Sequence similaritiesi

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiCOG5641.
GeneTreeiENSGT00750000117615.
HOGENOMiHOG000047700.
HOVERGENiHBG051703.
InParanoidiQ3UQJ2.
KOiK17897.
OMAiGAHPGWP.
OrthoDBiEOG7CCBRF.
PhylomeDBiQ61169.
TreeFamiTF315391.

Family and domain databases

Gene3Di3.30.50.10. 2 hits.
InterProiIPR008013. GATA_N.
IPR028437. TF_GATA_6.
IPR000679. Znf_GATA.
IPR013088. Znf_NHR/GATA.
[Graphical view]
PANTHERiPTHR10071:SF23. PTHR10071:SF23. 1 hit.
PfamiPF00320. GATA. 2 hits.
PF05349. GATA-N. 1 hit.
[Graphical view]
PRINTSiPR00619. GATAZNFINGER.
SMARTiSM00401. ZnF_GATA. 2 hits.
[Graphical view]
PROSITEiPS00344. GATA_ZN_FINGER_1. 2 hits.
PS50114. GATA_ZN_FINGER_2. 2 hits.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative initiation. Align

Isoform 1 (identifier: Q61169-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MALTDGGWCL PKRFGAAAAD AGDSGPFPAR EPSSPLSPIS SSSSSCSRGG    50
DRGPCGASNC RTPQLDAEAV AGPPGRSLLL SPYASHPFAA AHGAAAPGVA 100
GPGSALSTWE DLLLFTDLDQ AATASKLLWS SRGAKLSPFA AEQPEEMYQT 150
LAALSSQGPA AYDGAPGGFV HSAAAAAAAA AAASSPVYVP TTRVGSMLSG 200
LPYLQGAGSG PSNHAGGAGA HPGWSQASAD SPPYGGGGAA GGGAAGPGGA 250
GSATAHASAR FPYSPSPPMA NGAARDPGGY VAAGGTGAGS VSGGGGSLAA 300
MGGREHQYSS LSAARPLNGT YHHHHHHHPT YSPYMAAPLT PAWPAGPFET 350
PVLHSLQGRA GAPLPVPRGP STDLLEDLSE SRECVNCGSI QTPLWRRDGT 400
GHYLCNACGL YSKMNGLSRP LIKPQKRVPS SRRLGLSCAN CHTTTTTLWR 450
RNAEGEPVCN ACGLYMKLHG VPRPLAMKKE GIQTRKRKPK NINKSKACSG 500
NSSGSVPMTP TSSSSNSDDC TKNTSPSTQA TTSGVGASVM SAVGENANPE 550
NSDLKYSGQD GLYIGVSLSS PAEVTSSVRQ DSWCALALA 589
Length:589
Mass (Da):59,307
Last modified:November 25, 2008 - v3
Checksum:i1A55474DA65EC6ED
GO
Isoform 2 (identifier: Q61169-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-146: Missing.

Note: Produced by alternative initiation at Met-147 of isoform 1.

Show »
Length:443
Mass (Da):44,702
Checksum:i27B98CD21D42D223
GO

Sequence cautioni

The sequence AAB37426.1 differs from that shown. Reason: Frameshift at positions 360 and 368.
The sequence AAC52841.1 differs from that shown. Reason: Frameshift at position 572.

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 146146Missing in isoform 2.
VSP_035779Add
BLAST

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti297 – 2971S → T in AAB37426. 1 Publication
Sequence conflicti416 – 4161G → A in AAC52841. 1 Publication
Sequence conflicti536 – 5361G → R in AAC52841. 1 Publication
Sequence conflicti538 – 5381Missing in AAC52841. 1 Publication
Sequence conflicti546 – 5461N → K in AAC52841. 1 Publication
Sequence conflicti589 – 5891A → V in AAB37426. 1 Publication
Sequence conflicti589 – 5891A → V in AAD55267. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
S82462 mRNA. Translation: AAB37426.1. Frameshift.
AF179425 mRNA. Translation: AAD55267.1.
AK142381 mRNA. Translation: BAE25049.1.
CH466592 Genomic DNA. Translation: EDL22985.1.
U51335 mRNA. Translation: AAC52841.1. Frameshift.
CCDSiCCDS29059.1. [Q61169-1]
RefSeqiNP_034388.2. NM_010258.3. [Q61169-1]
UniGeneiMm.329287.

Genome annotation databases

EnsembliENSMUST00000047762; ENSMUSP00000041774; ENSMUSG00000005836. [Q61169-1]
GeneIDi14465.
KEGGimmu:14465.
UCSCiuc008ebj.1. mouse. [Q61169-1]

Keywords - Coding sequence diversityi

Alternative initiation

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
S82462 mRNA. Translation: AAB37426.1 . Frameshift.
AF179425 mRNA. Translation: AAD55267.1 .
AK142381 mRNA. Translation: BAE25049.1 .
CH466592 Genomic DNA. Translation: EDL22985.1 .
U51335 mRNA. Translation: AAC52841.1 . Frameshift.
CCDSi CCDS29059.1. [Q61169-1 ]
RefSeqi NP_034388.2. NM_010258.3. [Q61169-1 ]
UniGenei Mm.329287.

3D structure databases

ProteinModelPortali Q61169.
SMRi Q61169. Positions 380-488.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 199843. 12 interactions.
IntActi Q61169. 2 interactions.
MINTi MINT-1782188.
STRINGi 10090.ENSMUSP00000041774.

PTM databases

PhosphoSitei Q61169.

Proteomic databases

PRIDEi Q61169.

Protocols and materials databases

DNASUi 14465.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000047762 ; ENSMUSP00000041774 ; ENSMUSG00000005836 . [Q61169-1 ]
GeneIDi 14465.
KEGGi mmu:14465.
UCSCi uc008ebj.1. mouse. [Q61169-1 ]

Organism-specific databases

CTDi 2627.
MGIi MGI:107516. Gata6.

Phylogenomic databases

eggNOGi COG5641.
GeneTreei ENSGT00750000117615.
HOGENOMi HOG000047700.
HOVERGENi HBG051703.
InParanoidi Q3UQJ2.
KOi K17897.
OMAi GAHPGWP.
OrthoDBi EOG7CCBRF.
PhylomeDBi Q61169.
TreeFami TF315391.

Enzyme and pathway databases

Reactomei REACT_198649. Factors involved in megakaryocyte development and platelet production.

Miscellaneous databases

NextBioi 286112.
PROi Q61169.
SOURCEi Search...

Gene expression databases

ArrayExpressi Q61169.
Bgeei Q61169.
CleanExi MM_GATA6.
Genevestigatori Q61169.

Family and domain databases

Gene3Di 3.30.50.10. 2 hits.
InterProi IPR008013. GATA_N.
IPR028437. TF_GATA_6.
IPR000679. Znf_GATA.
IPR013088. Znf_NHR/GATA.
[Graphical view ]
PANTHERi PTHR10071:SF23. PTHR10071:SF23. 1 hit.
Pfami PF00320. GATA. 2 hits.
PF05349. GATA-N. 1 hit.
[Graphical view ]
PRINTSi PR00619. GATAZNFINGER.
SMARTi SM00401. ZnF_GATA. 2 hits.
[Graphical view ]
PROSITEi PS00344. GATA_ZN_FINGER_1. 2 hits.
PS50114. GATA_ZN_FINGER_2. 2 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "GATA-6: a zinc finger transcription factor that is expressed in multiple cell lineages derived from lateral mesoderm."
    Morrisey E.E., Ip H.S., Lu M.M., Parmacek M.S.
    Dev. Biol. 177:309-322(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
    Tissue: Heart.
  2. Katsuoka F., Motohashi H., Yamamoto M.
    Submitted (AUG-1999) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
    Strain: C57BL/6 X DBA/2.
    Tissue: Heart.
  3. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Strain: C57BL/6J.
    Tissue: Lung.
  4. Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
    Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "The gene for transcription factor GATA-6 resides on mouse chromosome 18 and is expressed in myocardium and vascular smooth muscle."
    Narita N., Heikinheimo M., Bielinska M., White R.A., Wilson D.B.
    Genomics 36:345-348(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 384-589 (ISOFORM 1).
    Strain: BALB/c.
    Tissue: Heart.
  6. "The human and mouse GATA-6 genes utilize two promoters and two initiation codons."
    Brewer A., Gove C., Davies A., McNulty C., Barrow D., Koutsourakis M., Farzaneh F., Pizzey J., Bomford A., Patient R.
    J. Biol. Chem. 274:38004-38016(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: ALTERNATIVE INITIATION.
  7. "LMCD1/Dyxin is a novel transcriptional cofactor that restricts GATA6 function by inhibiting DNA binding."
    Rath N., Wang Z., Lu M.M., Morrisey E.E.
    Mol. Cell. Biol. 25:8864-8873(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBCELLULAR LOCATION, INTERACTION WITH LMCD1, DOMAIN GATA-TYPE ZINC-FINGER.
  8. "GATA6 mutations cause human cardiac outflow tract defects by disrupting semaphorin-plexin signaling."
    Kodo K., Nishizawa T., Furutani M., Arai S., Yamamura E., Joo K., Takahashi T., Matsuoka R., Yamagishi H.
    Proc. Natl. Acad. Sci. U.S.A. 106:13933-13938(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.

Entry informationi

Entry nameiGATA6_MOUSE
AccessioniPrimary (citable) accession number: Q61169
Secondary accession number(s): P97729, Q3UQJ2, Q9QZK3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 25, 2008
Last modified: September 3, 2014
This is version 124 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi