Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

Q61169

- GATA6_MOUSE

UniProt

Q61169 - GATA6_MOUSE

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

Transcription factor GATA-6

Gene

Gata6

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Transcriptional activator that regulates SEMA3C and PLXNA2. Involved in gene regulation specifically in the gastric epithelium (By similarity). Involved in bone morphogenetic protein (BMP)-mediated cardiac-specific gene expression (PubMed:15329343). Binds to BMP response element (BMPRE) DNA sequences within cardiac activating regions (PubMed:15329343).By similarity2 Publications

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri384 – 40825GATA-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri438 – 46225GATA-type 2PROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

  1. chromatin binding Source: MGI
  2. DNA binding Source: MGI
  3. RNA polymerase II core promoter sequence-specific DNA binding Source: MGI
  4. RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity Source: MGI
  5. RNA polymerase II repressing transcription factor binding Source: BHF-UCL
  6. sequence-specific DNA binding Source: MGI
  7. sequence-specific DNA binding transcription factor activity Source: MGI
  8. transcription factor binding Source: MGI
  9. zinc ion binding Source: InterPro

GO - Biological processi

  1. cardiac muscle cell differentiation Source: BHF-UCL
  2. cardiac muscle hypertrophy in response to stress Source: MGI
  3. cardiac muscle tissue development Source: MGI
  4. cardiac vascular smooth muscle cell differentiation Source: Ensembl
  5. cellular response to BMP stimulus Source: MGI
  6. cellular response to gonadotropin stimulus Source: MGI
  7. cellular response to hypoxia Source: Ensembl
  8. Clara cell differentiation Source: MGI
  9. endodermal cell differentiation Source: MGI
  10. endodermal cell fate determination Source: MGI
  11. epithelial cell differentiation Source: MGI
  12. intestinal epithelial cell differentiation Source: MGI
  13. in utero embryonic development Source: MGI
  14. liver development Source: MGI
  15. lung saccule development Source: MGI
  16. male gonad development Source: Ensembl
  17. negative regulation of apoptotic process Source: Ensembl
  18. negative regulation of transcription from RNA polymerase II promoter Source: Ensembl
  19. negative regulation of transforming growth factor beta1 production Source: Ensembl
  20. negative regulation of transforming growth factor beta2 production Source: Ensembl
  21. organ formation Source: MGI
  22. outflow tract septum morphogenesis Source: Ensembl
  23. pancreas development Source: MGI
  24. pancreatic A cell differentiation Source: MGI
  25. phospholipid metabolic process Source: MGI
  26. positive regulation of angiogenesis Source: Ensembl
  27. positive regulation of cardiac muscle cell proliferation Source: MGI
  28. positive regulation of cardioblast differentiation Source: BHF-UCL
  29. positive regulation of cell cycle arrest Source: Ensembl
  30. positive regulation of transcription, DNA-templated Source: MGI
  31. positive regulation of transcription from RNA polymerase II promoter Source: BHF-UCL
  32. regulation of gene expression Source: MGI
  33. response to drug Source: Ensembl
  34. response to estrogen Source: MGI
  35. tube morphogenesis Source: MGI
  36. type B pancreatic cell differentiation Source: MGI
  37. Type II pneumocyte differentiation Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

Activator

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Enzyme and pathway databases

ReactomeiREACT_198649. Factors involved in megakaryocyte development and platelet production.

Names & Taxonomyi

Protein namesi
Recommended name:
Transcription factor GATA-6
Alternative name(s):
GATA-binding factor 6
Gene namesi
Name:Gata6
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 18

Organism-specific databases

MGIiMGI:107516. Gata6.

Subcellular locationi

Nucleus 1 Publication

GO - Cellular componenti

  1. nucleus Source: MGI
  2. transcription factor complex Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 589589Transcription factor GATA-6PRO_0000083424Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei266 – 2661PhosphoserineBy similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

PRIDEiQ61169.

PTM databases

PhosphoSiteiQ61169.

Expressioni

Tissue specificityi

Expressed in myocardium, vascular smooth muscle, gut epithelium, and osteoclasts.

Gene expression databases

BgeeiQ61169.
CleanExiMM_GATA6.
ExpressionAtlasiQ61169. baseline and differential.
GenevestigatoriQ61169.

Interactioni

Subunit structurei

Interacts with LMCD1.1 Publication

Protein-protein interaction databases

BioGridi199843. 12 interactions.
IntActiQ61169. 2 interactions.
MINTiMINT-1782188.
STRINGi10090.ENSMUSP00000041774.

Structurei

3D structure databases

ProteinModelPortaliQ61169.
SMRiQ61169. Positions 380-488.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi173 – 18311Poly-AlaAdd
BLAST
Compositional biasi322 – 3287Poly-His
Compositional biasi443 – 4475Poly-Thr

Domaini

The GATA-type zinc fingers mediate interaction with LMCD1.1 Publication

Sequence similaritiesi

Contains 2 GATA-type zinc fingers.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri384 – 40825GATA-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri438 – 46225GATA-type 2PROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiCOG5641.
GeneTreeiENSGT00760000119221.
HOGENOMiHOG000047700.
HOVERGENiHBG051703.
InParanoidiQ61169.
KOiK17897.
OMAiGAHPGWP.
OrthoDBiEOG7CCBRF.
PhylomeDBiQ61169.
TreeFamiTF315391.

Family and domain databases

Gene3Di3.30.50.10. 2 hits.
InterProiIPR008013. GATA_N.
IPR028437. TF_GATA_6.
IPR000679. Znf_GATA.
IPR013088. Znf_NHR/GATA.
[Graphical view]
PANTHERiPTHR10071:SF23. PTHR10071:SF23. 1 hit.
PfamiPF00320. GATA. 2 hits.
PF05349. GATA-N. 1 hit.
[Graphical view]
PRINTSiPR00619. GATAZNFINGER.
SMARTiSM00401. ZnF_GATA. 2 hits.
[Graphical view]
PROSITEiPS00344. GATA_ZN_FINGER_1. 2 hits.
PS50114. GATA_ZN_FINGER_2. 2 hits.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative initiation. Align

Isoform 1 (identifier: Q61169-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MALTDGGWCL PKRFGAAAAD AGDSGPFPAR EPSSPLSPIS SSSSSCSRGG
60 70 80 90 100
DRGPCGASNC RTPQLDAEAV AGPPGRSLLL SPYASHPFAA AHGAAAPGVA
110 120 130 140 150
GPGSALSTWE DLLLFTDLDQ AATASKLLWS SRGAKLSPFA AEQPEEMYQT
160 170 180 190 200
LAALSSQGPA AYDGAPGGFV HSAAAAAAAA AAASSPVYVP TTRVGSMLSG
210 220 230 240 250
LPYLQGAGSG PSNHAGGAGA HPGWSQASAD SPPYGGGGAA GGGAAGPGGA
260 270 280 290 300
GSATAHASAR FPYSPSPPMA NGAARDPGGY VAAGGTGAGS VSGGGGSLAA
310 320 330 340 350
MGGREHQYSS LSAARPLNGT YHHHHHHHPT YSPYMAAPLT PAWPAGPFET
360 370 380 390 400
PVLHSLQGRA GAPLPVPRGP STDLLEDLSE SRECVNCGSI QTPLWRRDGT
410 420 430 440 450
GHYLCNACGL YSKMNGLSRP LIKPQKRVPS SRRLGLSCAN CHTTTTTLWR
460 470 480 490 500
RNAEGEPVCN ACGLYMKLHG VPRPLAMKKE GIQTRKRKPK NINKSKACSG
510 520 530 540 550
NSSGSVPMTP TSSSSNSDDC TKNTSPSTQA TTSGVGASVM SAVGENANPE
560 570 580
NSDLKYSGQD GLYIGVSLSS PAEVTSSVRQ DSWCALALA
Length:589
Mass (Da):59,307
Last modified:November 25, 2008 - v3
Checksum:i1A55474DA65EC6ED
GO
Isoform 2 (identifier: Q61169-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-146: Missing.

Note: Produced by alternative initiation at Met-147 of isoform 1.

Show »
Length:443
Mass (Da):44,702
Checksum:i27B98CD21D42D223
GO

Sequence cautioni

The sequence AAB37426.1 differs from that shown. Reason: Frameshift at positions 360 and 368. Curated
The sequence AAC52841.1 differs from that shown. Reason: Frameshift at position 572. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti297 – 2971S → T in AAB37426. (PubMed:8660897)Curated
Sequence conflicti416 – 4161G → A in AAC52841. (PubMed:8812463)Curated
Sequence conflicti536 – 5361G → R in AAC52841. (PubMed:8812463)Curated
Sequence conflicti538 – 5381Missing in AAC52841. (PubMed:8812463)Curated
Sequence conflicti546 – 5461N → K in AAC52841. (PubMed:8812463)Curated
Sequence conflicti589 – 5891A → V in AAB37426. (PubMed:8660897)Curated
Sequence conflicti589 – 5891A → V in AAD55267. 1 PublicationCurated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 146146Missing in isoform 2. 2 PublicationsVSP_035779Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
S82462 mRNA. Translation: AAB37426.1. Frameshift.
AF179425 mRNA. Translation: AAD55267.1.
AK142381 mRNA. Translation: BAE25049.1.
CH466592 Genomic DNA. Translation: EDL22985.1.
U51335 mRNA. Translation: AAC52841.1. Frameshift.
CCDSiCCDS29059.1. [Q61169-1]
RefSeqiNP_034388.2. NM_010258.3. [Q61169-1]
UniGeneiMm.329287.

Genome annotation databases

EnsembliENSMUST00000047762; ENSMUSP00000041774; ENSMUSG00000005836. [Q61169-1]
GeneIDi14465.
KEGGimmu:14465.
UCSCiuc008ebj.1. mouse. [Q61169-1]

Keywords - Coding sequence diversityi

Alternative initiation

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
S82462 mRNA. Translation: AAB37426.1 . Frameshift.
AF179425 mRNA. Translation: AAD55267.1 .
AK142381 mRNA. Translation: BAE25049.1 .
CH466592 Genomic DNA. Translation: EDL22985.1 .
U51335 mRNA. Translation: AAC52841.1 . Frameshift.
CCDSi CCDS29059.1. [Q61169-1 ]
RefSeqi NP_034388.2. NM_010258.3. [Q61169-1 ]
UniGenei Mm.329287.

3D structure databases

ProteinModelPortali Q61169.
SMRi Q61169. Positions 380-488.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 199843. 12 interactions.
IntActi Q61169. 2 interactions.
MINTi MINT-1782188.
STRINGi 10090.ENSMUSP00000041774.

PTM databases

PhosphoSitei Q61169.

Proteomic databases

PRIDEi Q61169.

Protocols and materials databases

DNASUi 14465.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000047762 ; ENSMUSP00000041774 ; ENSMUSG00000005836 . [Q61169-1 ]
GeneIDi 14465.
KEGGi mmu:14465.
UCSCi uc008ebj.1. mouse. [Q61169-1 ]

Organism-specific databases

CTDi 2627.
MGIi MGI:107516. Gata6.

Phylogenomic databases

eggNOGi COG5641.
GeneTreei ENSGT00760000119221.
HOGENOMi HOG000047700.
HOVERGENi HBG051703.
InParanoidi Q61169.
KOi K17897.
OMAi GAHPGWP.
OrthoDBi EOG7CCBRF.
PhylomeDBi Q61169.
TreeFami TF315391.

Enzyme and pathway databases

Reactomei REACT_198649. Factors involved in megakaryocyte development and platelet production.

Miscellaneous databases

NextBioi 286112.
PROi Q61169.
SOURCEi Search...

Gene expression databases

Bgeei Q61169.
CleanExi MM_GATA6.
ExpressionAtlasi Q61169. baseline and differential.
Genevestigatori Q61169.

Family and domain databases

Gene3Di 3.30.50.10. 2 hits.
InterProi IPR008013. GATA_N.
IPR028437. TF_GATA_6.
IPR000679. Znf_GATA.
IPR013088. Znf_NHR/GATA.
[Graphical view ]
PANTHERi PTHR10071:SF23. PTHR10071:SF23. 1 hit.
Pfami PF00320. GATA. 2 hits.
PF05349. GATA-N. 1 hit.
[Graphical view ]
PRINTSi PR00619. GATAZNFINGER.
SMARTi SM00401. ZnF_GATA. 2 hits.
[Graphical view ]
PROSITEi PS00344. GATA_ZN_FINGER_1. 2 hits.
PS50114. GATA_ZN_FINGER_2. 2 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "GATA-6: a zinc finger transcription factor that is expressed in multiple cell lineages derived from lateral mesoderm."
    Morrisey E.E., Ip H.S., Lu M.M., Parmacek M.S.
    Dev. Biol. 177:309-322(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
    Tissue: Heart.
  2. Katsuoka F., Motohashi H., Yamamoto M.
    Submitted (AUG-1999) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
    Strain: C57BL/6 X DBA/2.
    Tissue: Heart.
  3. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Strain: C57BL/6J.
    Tissue: Lung.
  4. Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
    Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "The gene for transcription factor GATA-6 resides on mouse chromosome 18 and is expressed in myocardium and vascular smooth muscle."
    Narita N., Heikinheimo M., Bielinska M., White R.A., Wilson D.B.
    Genomics 36:345-348(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 384-589 (ISOFORM 1).
    Strain: BALB/c.
    Tissue: Heart.
  6. "The human and mouse GATA-6 genes utilize two promoters and two initiation codons."
    Brewer A., Gove C., Davies A., McNulty C., Barrow D., Koutsourakis M., Farzaneh F., Pizzey J., Bomford A., Patient R.
    J. Biol. Chem. 274:38004-38016(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: ALTERNATIVE INITIATION.
  7. "SMAD-mediated modulation of YY1 activity regulates the BMP response and cardiac-specific expression of a GATA4/5/6-dependent chick Nkx2.5 enhancer."
    Lee K.H., Evans S., Ruan T.Y., Lassar A.B.
    Development 131:4709-4723(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, DNA-BINDING.
  8. "LMCD1/Dyxin is a novel transcriptional cofactor that restricts GATA6 function by inhibiting DNA binding."
    Rath N., Wang Z., Lu M.M., Morrisey E.E.
    Mol. Cell. Biol. 25:8864-8873(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBCELLULAR LOCATION, INTERACTION WITH LMCD1, DOMAIN GATA-TYPE ZINC-FINGER.
  9. "GATA6 mutations cause human cardiac outflow tract defects by disrupting semaphorin-plexin signaling."
    Kodo K., Nishizawa T., Furutani M., Arai S., Yamamura E., Joo K., Takahashi T., Matsuoka R., Yamagishi H.
    Proc. Natl. Acad. Sci. U.S.A. 106:13933-13938(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.

Entry informationi

Entry nameiGATA6_MOUSE
AccessioniPrimary (citable) accession number: Q61169
Secondary accession number(s): P97729, Q3UQJ2, Q9QZK3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 25, 2008
Last modified: October 29, 2014
This is version 126 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3