Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Transcription factor GATA-6

Gene

Gata6

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Transcriptional activator that regulates SEMA3C and PLXNA2 (PubMed:19666519). May regulate genes that protect epithelial cells from bacterial infection (By similarity). Involved in gene regulation specifically in the gastric epithelium (By similarity). Involved in bone morphogenetic protein (BMP)-mediated cardiac-specific gene expression (PubMed:15329343). Binds to BMP response element (BMPRE) DNA sequences within cardiac activating regions (PubMed:15329343).By similarity2 Publications

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri384 – 408GATA-type 1PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri438 – 462GATA-type 2PROSITE-ProRule annotationAdd BLAST25

GO - Molecular functioni

GO - Biological processi

  • animal organ formation Source: MGI
  • cardiac muscle cell differentiation Source: MGI
  • cardiac muscle hypertrophy in response to stress Source: MGI
  • cardiac muscle tissue development Source: MGI
  • cardiac vascular smooth muscle cell differentiation Source: MGI
  • cellular response to BMP stimulus Source: MGI
  • cellular response to gonadotropin stimulus Source: MGI
  • cellular response to hypoxia Source: MGI
  • Clara cell differentiation Source: MGI
  • endodermal cell differentiation Source: MGI
  • endodermal cell fate determination Source: MGI
  • epithelial cell differentiation Source: MGI
  • intestinal epithelial cell differentiation Source: MGI
  • in utero embryonic development Source: MGI
  • liver development Source: MGI
  • lung saccule development Source: MGI
  • male gonad development Source: Ensembl
  • negative regulation of apoptotic process Source: MGI
  • negative regulation of pri-miRNA transcription by RNA polymerase II Source: MGI
  • negative regulation of transcription, DNA-templated Source: MGI
  • negative regulation of transcription by RNA polymerase II Source: MGI
  • negative regulation of transforming growth factor beta1 production Source: MGI
  • negative regulation of transforming growth factor beta2 production Source: MGI
  • outflow tract septum morphogenesis Source: MGI
  • pancreas development Source: MGI
  • pancreatic A cell differentiation Source: MGI
  • phospholipid metabolic process Source: MGI
  • positive regulation of angiogenesis Source: MGI
  • positive regulation of apoptotic process Source: MGI
  • positive regulation of BMP signaling pathway Source: MGI
  • positive regulation of cardiac muscle cell apoptotic process Source: MGI
  • positive regulation of cardiac muscle cell proliferation Source: MGI
  • positive regulation of cardiac muscle myoblast proliferation Source: MGI
  • positive regulation of cardioblast differentiation Source: BHF-UCL
  • positive regulation of cell cycle arrest Source: MGI
  • positive regulation of transcription, DNA-templated Source: MGI
  • positive regulation of transcription by RNA polymerase II Source: MGI
  • regulation of gene expression Source: MGI
  • response to drug Source: MGI
  • response to estrogen Source: MGI
  • response to growth factor Source: MGI
  • smooth muscle cell differentiation Source: MGI
  • transcription by RNA polymerase II Source: MGI
  • tube morphogenesis Source: MGI
  • type B pancreatic cell differentiation Source: MGI
  • Type II pneumocyte differentiation Source: MGI

Keywordsi

Molecular functionActivator, DNA-binding
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-MMU-5683826 Surfactant metabolism
R-MMU-983231 Factors involved in megakaryocyte development and platelet production

Names & Taxonomyi

Protein namesi
Recommended name:
Transcription factor GATA-6
Alternative name(s):
GATA-binding factor 6
Gene namesi
Name:Gata6
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 18

Organism-specific databases

MGIiMGI:107516 Gata6

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000834241 – 589Transcription factor GATA-6Add BLAST589

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei266PhosphoserineBy similarity1
Cross-linki423Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linki467Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linki478Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity

Keywords - PTMi

Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

PaxDbiQ61169
PeptideAtlasiQ61169
PRIDEiQ61169

PTM databases

iPTMnetiQ61169
PhosphoSitePlusiQ61169

Expressioni

Tissue specificityi

Expressed in myocardium, vascular smooth muscle, gut epithelium, and osteoclasts.

Gene expression databases

BgeeiENSMUSG00000005836
CleanExiMM_GATA6
GenevisibleiQ61169 MM

Interactioni

Subunit structurei

Interacts with LMCD1.1 Publication

GO - Molecular functioni

  • protein kinase binding Source: MGI
  • RNA polymerase II repressing transcription factor binding Source: BHF-UCL
  • transcription factor binding Source: MGI

Protein-protein interaction databases

BioGridi199843, 11 interactors
IntActiQ61169, 2 interactors
MINTiQ61169
STRINGi10090.ENSMUSP00000041774

Structurei

3D structure databases

ProteinModelPortaliQ61169
SMRiQ61169
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi173 – 183Poly-AlaAdd BLAST11
Compositional biasi322 – 328Poly-His7
Compositional biasi443 – 447Poly-Thr5

Domaini

The GATA-type zinc fingers mediate interaction with LMCD1.1 Publication

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri384 – 408GATA-type 1PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri438 – 462GATA-type 2PROSITE-ProRule annotationAdd BLAST25

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1601 Eukaryota
COG5641 LUCA
GeneTreeiENSGT00760000119221
HOGENOMiHOG000047700
HOVERGENiHBG051703
InParanoidiQ61169
KOiK17897
OMAiGAHPGWP
OrthoDBiEOG091G0AUR
PhylomeDBiQ61169
TreeFamiTF315391

Family and domain databases

Gene3Di3.30.50.10, 2 hits
InterProiView protein in InterPro
IPR008013 GATA_N
IPR016375 TF_GATA_4/5/6
IPR000679 Znf_GATA
IPR013088 Znf_NHR/GATA
PfamiView protein in Pfam
PF00320 GATA, 2 hits
PF05349 GATA-N, 1 hit
PIRSFiPIRSF003028 TF_GATA_4/5/6, 1 hit
PRINTSiPR00619 GATAZNFINGER
SMARTiView protein in SMART
SM00401 ZnF_GATA, 2 hits
PROSITEiView protein in PROSITE
PS00344 GATA_ZN_FINGER_1, 2 hits
PS50114 GATA_ZN_FINGER_2, 2 hits

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative initiation. AlignAdd to basket

Isoform 1 (identifier: Q61169-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MALTDGGWCL PKRFGAAAAD AGDSGPFPAR EPSSPLSPIS SSSSSCSRGG
60 70 80 90 100
DRGPCGASNC RTPQLDAEAV AGPPGRSLLL SPYASHPFAA AHGAAAPGVA
110 120 130 140 150
GPGSALSTWE DLLLFTDLDQ AATASKLLWS SRGAKLSPFA AEQPEEMYQT
160 170 180 190 200
LAALSSQGPA AYDGAPGGFV HSAAAAAAAA AAASSPVYVP TTRVGSMLSG
210 220 230 240 250
LPYLQGAGSG PSNHAGGAGA HPGWSQASAD SPPYGGGGAA GGGAAGPGGA
260 270 280 290 300
GSATAHASAR FPYSPSPPMA NGAARDPGGY VAAGGTGAGS VSGGGGSLAA
310 320 330 340 350
MGGREHQYSS LSAARPLNGT YHHHHHHHPT YSPYMAAPLT PAWPAGPFET
360 370 380 390 400
PVLHSLQGRA GAPLPVPRGP STDLLEDLSE SRECVNCGSI QTPLWRRDGT
410 420 430 440 450
GHYLCNACGL YSKMNGLSRP LIKPQKRVPS SRRLGLSCAN CHTTTTTLWR
460 470 480 490 500
RNAEGEPVCN ACGLYMKLHG VPRPLAMKKE GIQTRKRKPK NINKSKACSG
510 520 530 540 550
NSSGSVPMTP TSSSSNSDDC TKNTSPSTQA TTSGVGASVM SAVGENANPE
560 570 580
NSDLKYSGQD GLYIGVSLSS PAEVTSSVRQ DSWCALALA
Length:589
Mass (Da):59,307
Last modified:November 25, 2008 - v3
Checksum:i1A55474DA65EC6ED
GO
Isoform 2 (identifier: Q61169-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-146: Missing.

Note: Produced by alternative initiation at Met-147 of isoform 1.
Show »
Length:443
Mass (Da):44,702
Checksum:i27B98CD21D42D223
GO

Sequence cautioni

The sequence AAB37426 differs from that shown. Reason: Frameshift at positions 360 and 368.Curated
The sequence AAC52841 differs from that shown. Reason: Frameshift at position 572.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti297S → T in AAB37426 (PubMed:8660897).Curated1
Sequence conflicti416G → A in AAC52841 (PubMed:8812463).Curated1
Sequence conflicti536G → R in AAC52841 (PubMed:8812463).Curated1
Sequence conflicti538Missing in AAC52841 (PubMed:8812463).Curated1
Sequence conflicti546N → K in AAC52841 (PubMed:8812463).Curated1
Sequence conflicti589A → V in AAB37426 (PubMed:8660897).Curated1
Sequence conflicti589A → V in AAD55267 (Ref. 2) Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0357791 – 146Missing in isoform 2. 2 PublicationsAdd BLAST146

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
S82462 mRNA Translation: AAB37426.1 Frameshift.
AF179425 mRNA Translation: AAD55267.1
AK142381 mRNA Translation: BAE25049.1
CH466592 Genomic DNA Translation: EDL22985.1
U51335 mRNA Translation: AAC52841.1 Frameshift.
CCDSiCCDS29059.1 [Q61169-1]
RefSeqiNP_034388.2, NM_010258.3 [Q61169-1]
UniGeneiMm.329287

Genome annotation databases

EnsembliENSMUST00000047762; ENSMUSP00000041774; ENSMUSG00000005836 [Q61169-1]
GeneIDi14465
KEGGimmu:14465
UCSCiuc008ebj.1 mouse [Q61169-1]

Keywords - Coding sequence diversityi

Alternative initiation

Similar proteinsi

Entry informationi

Entry nameiGATA6_MOUSE
AccessioniPrimary (citable) accession number: Q61169
Secondary accession number(s): P97729, Q3UQJ2, Q9QZK3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 25, 2008
Last modified: June 20, 2018
This is version 156 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health