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Protein

Lysosomal-associated transmembrane protein 5

Gene

Laptm5

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

May have a special functional role during embryogenesis and in adult hematopoietic cells.1 Publication

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Transport

Protein family/group databases

TCDBi2.A.74.1.2. the 4 tms multidrug endosomal transporter (met) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Lysosomal-associated transmembrane protein 5
Alternative name(s):
Lysosomal-associated multitransmembrane protein 5
Retinoic acid-inducible E3 protein
Gene namesi
Name:Laptm5
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 4

Organism-specific databases

MGIiMGI:108046. Laptm5.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei21 – 4121HelicalSequence analysisAdd
BLAST
Transmembranei65 – 8521HelicalSequence analysisAdd
BLAST
Transmembranei92 – 11221HelicalSequence analysisAdd
BLAST
Transmembranei133 – 15321HelicalSequence analysisAdd
BLAST
Transmembranei183 – 20321HelicalSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Lysosome, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 261261Lysosomal-associated transmembrane protein 5PRO_0000084358Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei258 – 2581PhosphotyrosineCombined sources

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ61168.
MaxQBiQ61168.
PaxDbiQ61168.
PRIDEiQ61168.

PTM databases

iPTMnetiQ61168.
PhosphoSiteiQ61168.

Expressioni

Tissue specificityi

Preferentially expressed in adult hematopoietic tissues. High levels in lymphoid and myeloid tissues.1 Publication

Developmental stagei

During embryonic development it is expressed in both hematopoietic and nonhematopoietic tissues.

Inductioni

By retinoic acid. Likely target of the activated retinoic acid receptor alpha.

Gene expression databases

BgeeiQ61168.
CleanExiMM_LAPTM5.
ExpressionAtlasiQ61168. baseline and differential.
GenevisibleiQ61168. MM.

Interactioni

Subunit structurei

Binds to ubiquitin.

Protein-protein interaction databases

BioGridi201109. 2 interactions.
DIPiDIP-37698N.
IntActiQ61168. 2 interactions.
MINTiMINT-7895808.
STRINGi10090.ENSMUSP00000118415.

Structurei

3D structure databases

ProteinModelPortaliQ61168.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi245 – 25713Pro-richAdd
BLAST

Sequence similaritiesi

Belongs to the LAPTM4/LAPTM5 transporter family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IFZA. Eukaryota.
ENOG410YPPU. LUCA.
GeneTreeiENSGT00390000012862.
HOVERGENiHBG052307.
InParanoidiQ61168.
KOiK12387.
OMAiCVWRCYK.
OrthoDBiEOG7K9K3R.
TreeFamiTF330843.

Family and domain databases

InterProiIPR004687. LAPTM4/5.
IPR018396. LAPTM_4A/5.
IPR018397. Lysosomal-assoc_TM_prot5.
[Graphical view]
PANTHERiPTHR12479. PTHR12479. 2 hits.
PTHR12479:SF2. PTHR12479:SF2. 2 hits.
PfamiPF03821. Mtp. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00799. mtp. 1 hit.

Sequencei

Sequence statusi: Complete.

Q61168-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MASRAAPVRQ TCCCFNIRVA TIALAIYHIV MSVLLFIEHV VEVARGKVSC
60 70 80 90 100
RFFKMPYLRM ADLLSSFLLI GVLFIISISL LFGVVKNREK YLIPFLSLQI
110 120 130 140 150
MDFLLCLLTL LGSYIELPAY LKLARPRPGP SKVPLMTLQL LDFCLSILTL
160 170 180 190 200
CSSYMEVPTY LNFKSMNHMN YLPSQEGVPH SQFINMMLIF SVAFITVLIL
210 220 230 240 250
KVYMFKCVYT CYKFLKHMNS AMEDSSSKMF LKVALPSYEE ALSLPPKTPE
260
GDPAPPPYSE V
Length:261
Mass (Da):29,602
Last modified:November 1, 1996 - v1
Checksum:i70B3FA0AFE6743D1
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti56 – 561P → A in AAB48192 (PubMed:8839844).Curated
Sequence conflicti116 – 1161E → D in AAB48192 (PubMed:8839844).Curated
Sequence conflicti126 – 1261P → S in AAB48192 (PubMed:8839844).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U51239 mRNA. Translation: AAB08976.1.
U29539 mRNA. Translation: AAB48192.1.
BC020993 mRNA. Translation: AAH20993.1.
BC055057 mRNA. Translation: AAH55057.1.
CCDSiCCDS18712.1.
RefSeqiNP_034816.1. NM_010686.3.
UniGeneiMm.271868.

Genome annotation databases

EnsembliENSMUST00000151698; ENSMUSP00000118415; ENSMUSG00000028581.
GeneIDi16792.
KEGGimmu:16792.
UCSCiuc008uzv.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U51239 mRNA. Translation: AAB08976.1.
U29539 mRNA. Translation: AAB48192.1.
BC020993 mRNA. Translation: AAH20993.1.
BC055057 mRNA. Translation: AAH55057.1.
CCDSiCCDS18712.1.
RefSeqiNP_034816.1. NM_010686.3.
UniGeneiMm.271868.

3D structure databases

ProteinModelPortaliQ61168.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi201109. 2 interactions.
DIPiDIP-37698N.
IntActiQ61168. 2 interactions.
MINTiMINT-7895808.
STRINGi10090.ENSMUSP00000118415.

Protein family/group databases

TCDBi2.A.74.1.2. the 4 tms multidrug endosomal transporter (met) family.

PTM databases

iPTMnetiQ61168.
PhosphoSiteiQ61168.

Proteomic databases

EPDiQ61168.
MaxQBiQ61168.
PaxDbiQ61168.
PRIDEiQ61168.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000151698; ENSMUSP00000118415; ENSMUSG00000028581.
GeneIDi16792.
KEGGimmu:16792.
UCSCiuc008uzv.1. mouse.

Organism-specific databases

CTDi7805.
MGIiMGI:108046. Laptm5.

Phylogenomic databases

eggNOGiENOG410IFZA. Eukaryota.
ENOG410YPPU. LUCA.
GeneTreeiENSGT00390000012862.
HOVERGENiHBG052307.
InParanoidiQ61168.
KOiK12387.
OMAiCVWRCYK.
OrthoDBiEOG7K9K3R.
TreeFamiTF330843.

Miscellaneous databases

ChiTaRSiLaptm5. mouse.
PROiQ61168.
SOURCEiSearch...

Gene expression databases

BgeeiQ61168.
CleanExiMM_LAPTM5.
ExpressionAtlasiQ61168. baseline and differential.
GenevisibleiQ61168. MM.

Family and domain databases

InterProiIPR004687. LAPTM4/5.
IPR018396. LAPTM_4A/5.
IPR018397. Lysosomal-assoc_TM_prot5.
[Graphical view]
PANTHERiPTHR12479. PTHR12479. 2 hits.
PTHR12479:SF2. PTHR12479:SF2. 2 hits.
PfamiPF03821. Mtp. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00799. mtp. 1 hit.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "LAPTM5: a novel lysosomal-associated multispanning membrane protein preferentially expressed in hematopoietic cells."
    Adra C.N., Zhu S., Ko J.-L., Guillemot J.-C., Cuervo A.M., Kobayashi H., Horiuchi T., Lelias J.-M., Rowley J.D., Lim B.
    Genomics 35:328-337(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, INTERACTION WITH UBIQUITIN, SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
    Strain: Swiss Webster / NIH.
  2. "E3, a hematopoietic-specific transcript directly regulated by the retinoic acid receptor alpha."
    Scott L.M., Mueller L., Collins S.J.
    Blood 88:2517-2530(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: MDF1.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: FVB/N.
    Tissue: Colon and Mammary gland.
  4. "Quantitative time-resolved phosphoproteomic analysis of mast cell signaling."
    Cao L., Yu K., Banh C., Nguyen V., Ritz A., Raphael B.J., Kawakami Y., Kawakami T., Salomon A.R.
    J. Immunol. 179:5864-5876(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-258, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Mast cell.

Entry informationi

Entry nameiLAPM5_MOUSE
AccessioniPrimary (citable) accession number: Q61168
Secondary accession number(s): Q60923
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: November 1, 1996
Last modified: July 6, 2016
This is version 115 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.