##gff-version 3 Q61165 UniProtKB Chain 1 820 . . . ID=PRO_0000052348;Note=Sodium/hydrogen exchanger 1 Q61165 UniProtKB Topological domain 1 102 . . . Note=Extracellular;Ontology_term=ECO:0000305;evidence=ECO:0000305 Q61165 UniProtKB Transmembrane 103 125 . . . Note=Helical%3B Name%3D1;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P19634 Q61165 UniProtKB Topological domain 126 134 . . . Note=Cytoplasmic;Ontology_term=ECO:0000305;evidence=ECO:0000305 Q61165 UniProtKB Transmembrane 135 152 . . . Note=Helical%3B Name%3D2;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P19634 Q61165 UniProtKB Topological domain 153 162 . . . Note=Extracellular;Ontology_term=ECO:0000305;evidence=ECO:0000305 Q61165 UniProtKB Transmembrane 163 180 . . . Note=Helical%3B Name%3D3;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P19634 Q61165 UniProtKB Topological domain 181 190 . . . Note=Cytoplasmic;Ontology_term=ECO:0000305;evidence=ECO:0000305 Q61165 UniProtKB Transmembrane 191 219 . . . Note=Helical%3B Name%3D4;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P19634 Q61165 UniProtKB Topological domain 220 226 . . . Note=Extracellular;Ontology_term=ECO:0000305;evidence=ECO:0000305 Q61165 UniProtKB Transmembrane 227 253 . . . Note=Helical%3B Name%3D5;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P19634 Q61165 UniProtKB Topological domain 254 256 . . . Note=Cytoplasmic;Ontology_term=ECO:0000305;evidence=ECO:0000305 Q61165 UniProtKB Transmembrane 257 287 . . . Note=Helical%3B Name%3D6;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P19634 Q61165 UniProtKB Topological domain 288 291 . . . Note=Extracellular;Ontology_term=ECO:0000305;evidence=ECO:0000305 Q61165 UniProtKB Transmembrane 292 326 . . . Note=Helical%3B Name%3D7;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P19634 Q61165 UniProtKB Topological domain 327 332 . . . Note=Cytoplasmic;Ontology_term=ECO:0000305;evidence=ECO:0000305 Q61165 UniProtKB Transmembrane 333 345 . . . Note=Helical%3B Name%3D8;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P19634 Q61165 UniProtKB Topological domain 346 354 . . . Note=Extracellular;Ontology_term=ECO:0000305;evidence=ECO:0000305 Q61165 UniProtKB Transmembrane 355 375 . . . Note=Helical%3B Name%3D9;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P19634 Q61165 UniProtKB Topological domain 376 377 . . . Note=Cytoplasmic;Ontology_term=ECO:0000305;evidence=ECO:0000305 Q61165 UniProtKB Transmembrane 378 408 . . . Note=Helical%3B Name%3D10;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P19634 Q61165 UniProtKB Topological domain 409 414 . . . Note=Extracellular;Ontology_term=ECO:0000305;evidence=ECO:0000305 Q61165 UniProtKB Transmembrane 415 442 . . . Note=Helical%3B Name%3D11;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P19634 Q61165 UniProtKB Topological domain 443 448 . . . Note=Cytoplasmic;Ontology_term=ECO:0000305;evidence=ECO:0000305 Q61165 UniProtKB Transmembrane 449 473 . . . Note=Helical%3B Name%3D12;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P19634 Q61165 UniProtKB Topological domain 474 479 . . . Note=Extracellular;Ontology_term=ECO:0000305;evidence=ECO:0000305 Q61165 UniProtKB Transmembrane 480 509 . . . Note=Helical%3B Name%3D13;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P19634 Q61165 UniProtKB Topological domain 510 820 . . . Note=Cytoplasmic;Ontology_term=ECO:0000305;evidence=ECO:0000305 Q61165 UniProtKB Region 40 74 . . . Note=Disordered;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite Q61165 UniProtKB Region 507 549 . . . Note=Interaction with TESC;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P19634 Q61165 UniProtKB Region 513 520 . . . Note=PI(4%2C5)P2-binding region;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P26431 Q61165 UniProtKB Region 519 549 . . . Note=Interaction with CHP2;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P19634 Q61165 UniProtKB Region 544 549 . . . Note=Confers pH-dependent PI(4%2C5)P2 binding;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P19634 Q61165 UniProtKB Region 556 564 . . . Note=PI(4%2C5)P2-binding region;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P26431 Q61165 UniProtKB Region 637 820 . . . Note=Interaction with CALM1;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P19634 Q61165 UniProtKB Region 637 820 . . . Note=Interaction with TESC;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P19634 Q61165 UniProtKB Region 688 691 . . . Note=Interaction with PPP3CA;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P19634 Q61165 UniProtKB Region 719 724 . . . Note=Interaction with PPP3CA;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P19634 Q61165 UniProtKB Region 748 820 . . . Note=Disordered;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite Q61165 UniProtKB Compositional bias 777 799 . . . Note=Polar residues;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite Q61165 UniProtKB Site 165 165 . . . Note=Channel pore-lining;Ontology_term=ECO:0000250;evidence=ECO:0000250 Q61165 UniProtKB Modified residue 603 603 . . . Note=Phosphoserine;Ontology_term=ECO:0007744,ECO:0007744;evidence=ECO:0007744|PubMed:17242355,ECO:0007744|PubMed:21183079;Dbxref=PMID:17242355,PMID:21183079 Q61165 UniProtKB Modified residue 606 606 . . . Note=Phosphoserine;Ontology_term=ECO:0007744;evidence=ECO:0007744|PubMed:21183079;Dbxref=PMID:21183079 Q61165 UniProtKB Modified residue 607 607 . . . Note=Phosphothreonine;Ontology_term=ECO:0007744;evidence=ECO:0007744|PubMed:21183079;Dbxref=PMID:21183079 Q61165 UniProtKB Modified residue 609 609 . . . Note=Phosphoserine;Ontology_term=ECO:0007744,ECO:0007744;evidence=ECO:0007744|PubMed:17242355,ECO:0007744|PubMed:21183079;Dbxref=PMID:17242355,PMID:21183079 Q61165 UniProtKB Modified residue 652 652 . . . Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P19634 Q61165 UniProtKB Modified residue 697 697 . . . Note=Phosphoserine;Ontology_term=ECO:0007744,ECO:0007744,ECO:0007744;evidence=ECO:0007744|PubMed:19131326,ECO:0007744|PubMed:19144319,ECO:0007744|PubMed:21183079;Dbxref=PMID:19131326,PMID:19144319,PMID:21183079 Q61165 UniProtKB Modified residue 701 701 . . . Note=Phosphoserine;Ontology_term=ECO:0007744;evidence=ECO:0007744|PubMed:21183079;Dbxref=PMID:21183079 Q61165 UniProtKB Modified residue 707 707 . . . Note=Phosphoserine;Ontology_term=ECO:0007744,ECO:0007744,ECO:0007744;evidence=ECO:0007744|PubMed:17242355,ECO:0007744|PubMed:19144319,ECO:0007744|PubMed:21183079;Dbxref=PMID:17242355,PMID:19144319,PMID:21183079 Q61165 UniProtKB Modified residue 727 727 . . . Note=Phosphoserine;Ontology_term=ECO:0007744;evidence=ECO:0007744|PubMed:21183079;Dbxref=PMID:21183079 Q61165 UniProtKB Modified residue 730 730 . . . Note=Phosphoserine;Ontology_term=ECO:0007744;evidence=ECO:0007744|PubMed:21183079;Dbxref=PMID:21183079 Q61165 UniProtKB Modified residue 733 733 . . . Note=Phosphoserine;Ontology_term=ECO:0007744;evidence=ECO:0007744|PubMed:21183079;Dbxref=PMID:21183079 Q61165 UniProtKB Modified residue 755 755 . . . Note=Phosphothreonine;Ontology_term=ECO:0007744;evidence=ECO:0007744|PubMed:21183079;Dbxref=PMID:21183079 Q61165 UniProtKB Modified residue 784 784 . . . Note=Phosphothreonine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P19634 Q61165 UniProtKB Modified residue 790 790 . . . Note=Phosphoserine;Ontology_term=ECO:0007744;evidence=ECO:0007744|PubMed:21183079;Dbxref=PMID:21183079 Q61165 UniProtKB Modified residue 792 792 . . . Note=Phosphoserine;Ontology_term=ECO:0007744;evidence=ECO:0007744|PubMed:21183079;Dbxref=PMID:21183079 Q61165 UniProtKB Modified residue 801 801 . . . Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P26431 Q61165 UniProtKB Natural variant 442 820 . . . Note=In swe. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:9335342;Dbxref=PMID:9335342