Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Transcriptional repressor CTCF

Gene

Ctcf

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Chromatin binding factor that binds to DNA sequence specific sites. Involved in transcriptional regulation by binding to chromatin insulators and preventing interaction between promoter and nearby enhancers and silencers. Acts as transcriptional repressor binding to promoters of vertebrate MYC gene and BAG1 gene. Also binds to the PLK and PIM1 promoters. Acts as a transcriptional activator of APP. Regulates APOA1/C3/A4/A5 gene cluster and controls MHC class II gene expression. Plays an essential role in oocyte and preimplantation embryo development by activating or repressing transcription. Seems to act as tumor suppressor. Plays a critical role in the epigenetic regulation. Participates in the allele-specific gene expression at the imprinted IGF2/H19 gene locus. On the maternal allele, binding within the H19 imprinting control region (ICR) mediates maternally inherited higher-order chromatin conformation to restrict enhancer access to IGF2. Plays a critical role in gene silencing over considerable distances in the genome. Preferentially interacts with unmethylated DNA, preventing spreading of CpG methylation and maintaining methylation-free zones. Inversely, binding to target sites is prevented by CpG methylation. Plays a important role in chromatin remodeling. Can dimerize when it is bound to different DNA sequences, mediating long-range chromatin looping (By similarity). Mediates interchromosomal association between IGF2/H19 and WSB1/NF1 and may direct distant DNA segments to a common transcription factory. Causes local loss of histone acetylation and gain of histone methylation in the beta-globin locus, without affecting transcription. When bound to chromatin, it provides an anchor point for nucleosomes positioning. Seems to be essential for homologous X-chromosome pairing. May participate with Tsix in establishing a regulatable epigenetic switch for X chromosome inactivation. May play a role in preventing the propagation of stable methylation at the escape genes from X-inactivation. Involved in sister chromatid cohesion. Associates with both centromeres and chromosomal arms during metaphase and required for cohesin localization to CTCF sites. Regulates asynchronous replication of IGF2/H19.By similarity7 Publications

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri266 – 28823C2H2-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri294 – 31623C2H2-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri322 – 34524C2H2-type 3PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri351 – 37323C2H2-type 4PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri379 – 40123C2H2-type 5PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri407 – 43024C2H2-type 6PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri437 – 46024C2H2-type 7PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri467 – 48923C2H2-type 8PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri495 – 51723C2H2-type 9PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri523 – 54624C2H2-type 10PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri555 – 57723C2H2-type 11; atypicalPROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

GO - Biological processi

  • chromatin modification Source: UniProtKB-KW
  • chromosome segregation Source: UniProtKB-KW
  • DNA methylation Source: MGI
  • dosage compensation by inactivation of X chromosome Source: MGI
  • maintenance of DNA methylation Source: MGI
  • negative regulation of gene expression Source: UniProtKB
  • negative regulation of transcription, DNA-templated Source: MGI
  • negative regulation of transcription from RNA polymerase II promoter Source: MGI
  • nucleosome positioning Source: MGI
  • positive regulation of gene expression Source: UniProtKB
  • positive regulation of transcription, DNA-templated Source: MGI
  • positive regulation of transcription from RNA polymerase II promoter Source: GOC
  • regulation of gene expression, epigenetic Source: MGI
  • regulation of gene expression by genetic imprinting Source: MGI
  • regulation of histone acetylation Source: UniProtKB
  • regulation of histone methylation Source: UniProtKB
  • regulation of molecular function, epigenetic Source: MGI
  • regulation of transcription, DNA-templated Source: MGI
  • transcription from RNA polymerase II promoter Source: GOC
Complete GO annotation...

Keywords - Molecular functioni

Activator, Chromatin regulator, Repressor

Keywords - Biological processi

Chromosome partition, Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Transcriptional repressor CTCF
Alternative name(s):
11-zinc finger protein
CCCTC-binding factor
CTCFL paralog
Gene namesi
Name:Ctcf
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589 Componenti: Chromosome 8

Organism-specific databases

MGIiMGI:109447. Ctcf.

Subcellular locationi

  • Nucleusnucleoplasm 1 Publication
  • Chromosome By similarity
  • Chromosomecentromere By similarity

  • Note: May translocate to the nucleolus upon cell differentiation. Associates with both centromeres and chromosomal arms during metaphase. Associates with the H19 ICR in mitotic chromosomes. May be preferentially excluded from heterochromatin during interphase (By similarity).By similarity

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Centromere, Chromosome, Nucleus

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Mutagenesisi74 – 741K → R: No sumoylation. 1 Publication
Mutagenesisi698 – 6981K → R: No sumoylation. 1 Publication

Keywords - Diseasei

Tumor suppressor

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 736736Transcriptional repressor CTCFPRO_0000047229Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei1 – 11N-acetylmethionineBy similarity
Cross-linki74 – 74Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO)
Modified residuei289 – 2891PhosphothreonineBy similarity
Modified residuei317 – 3171PhosphothreonineBy similarity
Modified residuei374 – 3741PhosphothreonineBy similarity
Modified residuei402 – 4021PhosphoserineBy similarity
Modified residuei609 – 6091PhosphoserineBy similarity
Modified residuei610 – 6101PhosphoserineBy similarity
Modified residuei612 – 6121PhosphoserineBy similarity
Cross-linki698 – 698Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO)

Post-translational modificationi

Sumoylated on Lys-74 and Lys-698; sumoylation of CTCF contributes to the repressive function of CTCF on the MYC P2 promoter.1 Publication

Keywords - PTMi

Acetylation, Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

MaxQBiQ61164.
PaxDbiQ61164.
PRIDEiQ61164.

Expressioni

Gene expression databases

BgeeiQ61164.
CleanExiMM_CTCF.
ExpressionAtlasiQ61164. baseline and differential.
GenevisibleiQ61164. MM.

Interactioni

Subunit structurei

Interacts with CHD8.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
Chd8Q09XV53EBI-932785,EBI-1169080

Protein-protein interaction databases

BioGridi198963. 20 interactions.
DIPiDIP-38020N.
IntActiQ61164. 15 interactions.
MINTiMINT-4092474.
STRINGi10090.ENSMUSP00000005841.

Structurei

3D structure databases

ProteinModelPortaliQ61164.
SMRiQ61164. Positions 263-591.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi635 – 67642Pro-richAdd
BLAST

Sequence similaritiesi

Belongs to the CTCF zinc-finger protein family.Curated
Contains 11 C2H2-type zinc fingers.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri266 – 28823C2H2-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri294 – 31623C2H2-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri322 – 34524C2H2-type 3PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri351 – 37323C2H2-type 4PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri379 – 40123C2H2-type 5PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri407 – 43024C2H2-type 6PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri437 – 46024C2H2-type 7PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri467 – 48923C2H2-type 8PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri495 – 51723C2H2-type 9PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri523 – 54624C2H2-type 10PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri555 – 57723C2H2-type 11; atypicalPROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiCOG5048.
GeneTreeiENSGT00530000063079.
HOGENOMiHOG000276534.
HOVERGENiHBG000350.
InParanoidiQ61164.
OMAiGVQMVMM.
OrthoDBiEOG71K632.
PhylomeDBiQ61164.
TreeFamiTF106430.

Family and domain databases

Gene3Di3.30.160.60. 9 hits.
InterProiIPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF00096. zf-C2H2. 1 hit.
[Graphical view]
SMARTiSM00355. ZnF_C2H2. 11 hits.
[Graphical view]
PROSITEiPS00028. ZINC_FINGER_C2H2_1. 8 hits.
PS50157. ZINC_FINGER_C2H2_2. 11 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q61164-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEGEAVEAIV EESETFIKGK ERKTYQRRRE GGQEEDACHL PQNQTDGGEV
60 70 80 90 100
VQDVNSSVQM VMMEQLDPTL LQMKTEVMEG TVAPEAEAAV DDTQIITLQV
110 120 130 140 150
VNMEEQPINI GELQLVQVPV PVTVPVATTS VEELQGAYEN EVSKEGLAES
160 170 180 190 200
EPMICHTLPL PEGFQVVKVG ANGEVETLEQ GELPPQEDSS WQKDPDYQPP
210 220 230 240 250
AKKTKKTKKS KLRYTEEGKD VDVSVYDFEE EQQEGLLSEV NAEKVVGNMK
260 270 280 290 300
PPKPTKIKKK GVKKTFQCEL CSYTCPRRSN LDRHMKSHTD ERPHKCHLCG
310 320 330 340 350
RAFRTVTLLR NHLNTHTGTR PHKCPDCDMA FVTSGELVRH RRYKHTHEKP
360 370 380 390 400
FKCSMCDYAS VEVSKLKRHI RSHTGERPFQ CSLCSYASRD TYKLKRHMRT
410 420 430 440 450
HSGEKPYECY ICHARFTQSG TMKMHILQKH TENVAKFHCP HCDTVIARKS
460 470 480 490 500
DLGVHLRKQH SYIEQGKKCR YCDAVFHERY ALIQHQKSHK NEKRFKCDQC
510 520 530 540 550
DYACRQERHM IMHKRTHTGE KPYACSHCDK TFRQKQLLDM HFKRYHDPNF
560 570 580 590 600
VPAAFVCSKC GKTFTRRNTM ARHADNCAGP DGVEGENGGE TKKSKRGRKR
610 620 630 640 650
KMRSKKEDSS DSEENAEPDL DDNEEEEEPA VEIEPEPEPQ PQPPPPPQPV
660 670 680 690 700
APAPPPAKKR RGRPPGRTNQ PKQNQPTAII QVEDQNTGAI ENIIVEVKKE
710 720 730
PDAEPAEGEE EEAQAATTDA PNGDLTPEMI LSMMDR
Length:736
Mass (Da):83,745
Last modified:April 23, 2003 - v2
Checksum:i7C49D4A7BDCFEFA1
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti38 – 381C → S in AAC52928 (PubMed:8649389).Curated
Sequence conflicti257 – 2571I → K in AAH37456 (PubMed:15489334).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U51037 mRNA. Translation: AAC52928.1.
BC037456 mRNA. Translation: AAH37456.1.
BC046398 mRNA. Translation: AAH46398.1.
BC049131 mRNA. Translation: AAH49131.1.
BC058240 mRNA. Translation: AAH58240.1.
AK076192 mRNA. Translation: BAC36245.1.
CCDSiCCDS22606.1.
RefSeqiNP_851839.1. NM_181322.3.
XP_006530711.1. XM_006530648.2.
UniGeneiMm.269474.

Genome annotation databases

EnsembliENSMUST00000005841; ENSMUSP00000005841; ENSMUSG00000005698.
GeneIDi13018.
KEGGimmu:13018.
UCSCiuc009ndm.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U51037 mRNA. Translation: AAC52928.1.
BC037456 mRNA. Translation: AAH37456.1.
BC046398 mRNA. Translation: AAH46398.1.
BC049131 mRNA. Translation: AAH49131.1.
BC058240 mRNA. Translation: AAH58240.1.
AK076192 mRNA. Translation: BAC36245.1.
CCDSiCCDS22606.1.
RefSeqiNP_851839.1. NM_181322.3.
XP_006530711.1. XM_006530648.2.
UniGeneiMm.269474.

3D structure databases

ProteinModelPortaliQ61164.
SMRiQ61164. Positions 263-591.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi198963. 20 interactions.
DIPiDIP-38020N.
IntActiQ61164. 15 interactions.
MINTiMINT-4092474.
STRINGi10090.ENSMUSP00000005841.

Proteomic databases

MaxQBiQ61164.
PaxDbiQ61164.
PRIDEiQ61164.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000005841; ENSMUSP00000005841; ENSMUSG00000005698.
GeneIDi13018.
KEGGimmu:13018.
UCSCiuc009ndm.2. mouse.

Organism-specific databases

CTDi10664.
MGIiMGI:109447. Ctcf.

Phylogenomic databases

eggNOGiCOG5048.
GeneTreeiENSGT00530000063079.
HOGENOMiHOG000276534.
HOVERGENiHBG000350.
InParanoidiQ61164.
OMAiGVQMVMM.
OrthoDBiEOG71K632.
PhylomeDBiQ61164.
TreeFamiTF106430.

Miscellaneous databases

ChiTaRSiCtcf. mouse.
NextBioi282878.
PROiQ61164.
SOURCEiSearch...

Gene expression databases

BgeeiQ61164.
CleanExiMM_CTCF.
ExpressionAtlasiQ61164. baseline and differential.
GenevisibleiQ61164. MM.

Family and domain databases

Gene3Di3.30.160.60. 9 hits.
InterProiIPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF00096. zf-C2H2. 1 hit.
[Graphical view]
SMARTiSM00355. ZnF_C2H2. 11 hits.
[Graphical view]
PROSITEiPS00028. ZINC_FINGER_C2H2_1. 8 hits.
PS50157. ZINC_FINGER_C2H2_2. 11 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "An exceptionally conserved transcriptional repressor, CTCF, employs different combinations of zinc fingers to bind diverged promoter sequences of avian and mammalian c-myc oncogenes."
    Filippova G.N., Fagerlie S., Klenova E.M., Myers C., Dehner Y., Goodwin G., Neiman P.E., Collins S.J., Lobanenkov V.V.
    Mol. Cell. Biol. 16:2802-2813(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], SUBCELLULAR LOCATION.
    Strain: BDF1.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Brain, Mammary gland and Olfactory epithelium.
  3. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-201.
    Strain: C57BL/6J.
    Tissue: Extraembryonic tissue and Placenta.
  4. "CTCF, a candidate trans-acting factor for X-inactivation choice."
    Chao W., Huynh K.D., Spencer R.J., Davidow L.S., Lee J.T.
    Science 295:345-347(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
  5. "Boundaries between chromosomal domains of X inactivation and escape bind CTCF and lack CpG methylation during early development."
    Filippova G.N., Cheng M.K., Moore J.M., Truong J.-P., Hu Y.J., Nguyen D.K., Tsuchiya K.D., Disteche C.M.
    Dev. Cell 8:31-42(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
  6. "CTCF mediates long-range chromatin looping and local histone modification in the beta-globin locus."
    Splinter E., Heath H., Kooren J., Palstra R.-J., Klous P., Grosveld F., Galjart N., de Laat W.
    Genes Dev. 20:2349-2354(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
  7. "CTCF-dependent chromatin insulator is linked to epigenetic remodeling."
    Ishihara K., Oshimura M., Nakao M.
    Mol. Cell 23:733-742(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH CHD8.
  8. "CTCF mediates interchromosomal colocalization between Igf2/H19 and Wsb1/Nf1."
    Ling J.Q., Li T., Hu J.F., Vu T.H., Chen H.L., Qiu X.W., Cherry A.M., Hoffman A.R.
    Science 312:269-272(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
  9. "CTCF regulates asynchronous replication of the imprinted H19/Igf2 domain."
    Bergstroem R., Whitehead J., Kurukuti S., Ohlsson R.
    Cell Cycle 6:450-454(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
  10. "Evidence that homologous X-chromosome pairing requires transcription and Ctcf protein."
    Xu N., Donohoe M.E., Silva S.S., Lee J.T.
    Nat. Genet. 39:1390-1396(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
  11. "Maternal depletion of CTCF reveals multiple functions during oocyte and preimplantation embryo development."
    Wan L.-B., Pan H., Hannenhalli S., Cheng Y., Ma J., Fedoriw A., Lobanenkov V., Latham K.E., Schultz R.M., Bartolomei M.S.
    Development 135:2729-2738(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
  12. "The CTCF insulator protein is posttranslationally modified by SUMO."
    MacPherson M.J., Beatty L.G., Zhou W., Du M., Sadowski P.D.
    Mol. Cell. Biol. 29:714-725(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUMOYLATION AT LYS-74 AND LYS-698, MUTAGENESIS OF LYS-74 AND LYS-698.

Entry informationi

Entry nameiCTCF_MOUSE
AccessioniPrimary (citable) accession number: Q61164
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 23, 2003
Last sequence update: April 23, 2003
Last modified: July 22, 2015
This is version 134 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.