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Q61164

- CTCF_MOUSE

UniProt

Q61164 - CTCF_MOUSE

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Protein

Transcriptional repressor CTCF

Gene

Ctcf

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Chromatin binding factor that binds to DNA sequence specific sites. Involved in transcriptional regulation by binding to chromatin insulators and preventing interaction between promoter and nearby enhancers and silencers. Acts as transcriptional repressor binding to promoters of vertebrate MYC gene and BAG1 gene. Also binds to the PLK and PIM1 promoters. Acts as a transcriptional activator of APP. Regulates APOA1/C3/A4/A5 gene cluster and controls MHC class II gene expression. Plays an essential role in oocyte and preimplantation embryo development by activating or repressing transcription. Seems to act as tumor suppressor. Plays a critical role in the epigenetic regulation. Participates in the allele-specific gene expression at the imprinted IGF2/H19 gene locus. On the maternal allele, binding within the H19 imprinting control region (ICR) mediates maternally inherited higher-order chromatin conformation to restrict enhancer access to IGF2. Plays a critical role in gene silencing over considerable distances in the genome. Preferentially interacts with unmethylated DNA, preventing spreading of CpG methylation and maintaining methylation-free zones. Inversely, binding to target sites is prevented by CpG methylation. Plays a important role in chromatin remodeling. Can dimerize when it is bound to different DNA sequences, mediating long-range chromatin looping (By similarity). Mediates interchromosomal association between IGF2/H19 and WSB1/NF1 and may direct distant DNA segments to a common transcription factory. Causes local loss of histone acetylation and gain of histone methylation in the beta-globin locus, without affecting transcription. When bound to chromatin, it provides an anchor point for nucleosomes positioning. Seems to be essential for homologous X-chromosome pairing. May participate with Tsix in establishing a regulatable epigenetic switch for X chromosome inactivation. May play a role in preventing the propagation of stable methylation at the escape genes from X-inactivation. Involved in sister chromatid cohesion. Associates with both centromeres and chromosomal arms during metaphase and required for cohesin localization to CTCF sites. Regulates asynchronous replication of IGF2/H19.By similarity7 Publications

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri266 – 28823C2H2-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri294 – 31623C2H2-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri322 – 34524C2H2-type 3PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri351 – 37323C2H2-type 4PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri379 – 40123C2H2-type 5PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri407 – 43024C2H2-type 6PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri437 – 46024C2H2-type 7PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri467 – 48923C2H2-type 8PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri495 – 51723C2H2-type 9PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri523 – 54624C2H2-type 10PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri555 – 57723C2H2-type 11; atypicalPROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

  1. chromatin binding Source: MGI
  2. chromatin insulator sequence binding Source: Ensembl
  3. DNA binding Source: MGI
  4. metal ion binding Source: UniProtKB-KW
  5. RNA polymerase II core promoter proximal region sequence-specific DNA binding Source: Ensembl
  6. RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription Source: Ensembl

GO - Biological processi

  1. chromatin modification Source: UniProtKB-KW
  2. chromosome segregation Source: UniProtKB-KW
  3. DNA methylation Source: MGI
  4. dosage compensation by inactivation of X chromosome Source: MGI
  5. maintenance of DNA methylation Source: MGI
  6. negative regulation of gene expression Source: UniProtKB
  7. negative regulation of transcription from RNA polymerase II promoter Source: MGI
  8. nucleosome positioning Source: Ensembl
  9. positive regulation of gene expression Source: UniProtKB
  10. positive regulation of transcription, DNA-templated Source: Ensembl
  11. regulation of gene expression by genetic imprinting Source: MGI
  12. regulation of histone acetylation Source: UniProtKB
  13. regulation of histone methylation Source: UniProtKB
  14. regulation of molecular function, epigenetic Source: Ensembl
  15. regulation of transcription, DNA-templated Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

Activator, Chromatin regulator, Repressor

Keywords - Biological processi

Chromosome partition, Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Transcriptional repressor CTCF
Alternative name(s):
11-zinc finger protein
CCCTC-binding factor
CTCFL paralog
Gene namesi
Name:Ctcf
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 8

Organism-specific databases

MGIiMGI:109447. Ctcf.

Subcellular locationi

Nucleusnucleoplasm 1 Publication. Chromosome By similarity. Chromosomecentromere By similarity
Note: May translocate to the nucleolus upon cell differentiation. Associates with both centromeres and chromosomal arms during metaphase. Associates with the H19 ICR in mitotic chromosomes. May be preferentially excluded from heterochromatin during interphase (By similarity).By similarity

GO - Cellular componenti

  1. chromosome, centromeric region Source: UniProtKB-KW
  2. condensed chromosome Source: Ensembl
  3. nucleolus Source: Ensembl
  4. nucleoplasm Source: Ensembl
  5. nucleus Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Centromere, Chromosome, Nucleus

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Mutagenesisi74 – 741K → R: No sumoylation. 1 Publication
Mutagenesisi698 – 6981K → R: No sumoylation. 1 Publication

Keywords - Diseasei

Tumor suppressor

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 736736Transcriptional repressor CTCFPRO_0000047229Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei1 – 11N-acetylmethionineBy similarity
Cross-linki74 – 74Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO)
Modified residuei289 – 2891PhosphothreonineBy similarity
Modified residuei317 – 3171PhosphothreonineBy similarity
Modified residuei374 – 3741PhosphothreonineBy similarity
Modified residuei402 – 4021PhosphoserineBy similarity
Modified residuei609 – 6091PhosphoserineBy similarity
Modified residuei610 – 6101PhosphoserineBy similarity
Modified residuei612 – 6121PhosphoserineBy similarity
Cross-linki698 – 698Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO)

Post-translational modificationi

Sumoylated on Lys-74 and Lys-698; sumoylation of CTCF contributes to the repressive function of CTCF on the MYC P2 promoter.1 Publication

Keywords - PTMi

Acetylation, Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

MaxQBiQ61164.
PaxDbiQ61164.
PRIDEiQ61164.

Expressioni

Gene expression databases

BgeeiQ61164.
CleanExiMM_CTCF.
ExpressionAtlasiQ61164. baseline and differential.
GenevestigatoriQ61164.

Interactioni

Subunit structurei

Interacts with CHD8.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
Chd8Q09XV53EBI-932785,EBI-1169080

Protein-protein interaction databases

BioGridi198963. 21 interactions.
DIPiDIP-38020N.
IntActiQ61164. 14 interactions.
MINTiMINT-4092474.
STRINGi10090.ENSMUSP00000005841.

Structurei

3D structure databases

ProteinModelPortaliQ61164.
SMRiQ61164. Positions 263-591.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi635 – 67642Pro-richAdd
BLAST

Sequence similaritiesi

Belongs to the CTCF zinc-finger protein family.Curated
Contains 11 C2H2-type zinc fingers.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri266 – 28823C2H2-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri294 – 31623C2H2-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri322 – 34524C2H2-type 3PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri351 – 37323C2H2-type 4PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri379 – 40123C2H2-type 5PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri407 – 43024C2H2-type 6PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri437 – 46024C2H2-type 7PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri467 – 48923C2H2-type 8PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri495 – 51723C2H2-type 9PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri523 – 54624C2H2-type 10PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri555 – 57723C2H2-type 11; atypicalPROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiCOG5048.
GeneTreeiENSGT00530000063079.
HOGENOMiHOG000276534.
HOVERGENiHBG000350.
InParanoidiQ61164.
OMAiPPNQADG.
OrthoDBiEOG71K632.
PhylomeDBiQ61164.
TreeFamiTF106430.

Family and domain databases

Gene3Di3.30.160.60. 9 hits.
InterProiIPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF00096. zf-C2H2. 1 hit.
[Graphical view]
SMARTiSM00355. ZnF_C2H2. 11 hits.
[Graphical view]
PROSITEiPS00028. ZINC_FINGER_C2H2_1. 8 hits.
PS50157. ZINC_FINGER_C2H2_2. 11 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q61164-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MEGEAVEAIV EESETFIKGK ERKTYQRRRE GGQEEDACHL PQNQTDGGEV
60 70 80 90 100
VQDVNSSVQM VMMEQLDPTL LQMKTEVMEG TVAPEAEAAV DDTQIITLQV
110 120 130 140 150
VNMEEQPINI GELQLVQVPV PVTVPVATTS VEELQGAYEN EVSKEGLAES
160 170 180 190 200
EPMICHTLPL PEGFQVVKVG ANGEVETLEQ GELPPQEDSS WQKDPDYQPP
210 220 230 240 250
AKKTKKTKKS KLRYTEEGKD VDVSVYDFEE EQQEGLLSEV NAEKVVGNMK
260 270 280 290 300
PPKPTKIKKK GVKKTFQCEL CSYTCPRRSN LDRHMKSHTD ERPHKCHLCG
310 320 330 340 350
RAFRTVTLLR NHLNTHTGTR PHKCPDCDMA FVTSGELVRH RRYKHTHEKP
360 370 380 390 400
FKCSMCDYAS VEVSKLKRHI RSHTGERPFQ CSLCSYASRD TYKLKRHMRT
410 420 430 440 450
HSGEKPYECY ICHARFTQSG TMKMHILQKH TENVAKFHCP HCDTVIARKS
460 470 480 490 500
DLGVHLRKQH SYIEQGKKCR YCDAVFHERY ALIQHQKSHK NEKRFKCDQC
510 520 530 540 550
DYACRQERHM IMHKRTHTGE KPYACSHCDK TFRQKQLLDM HFKRYHDPNF
560 570 580 590 600
VPAAFVCSKC GKTFTRRNTM ARHADNCAGP DGVEGENGGE TKKSKRGRKR
610 620 630 640 650
KMRSKKEDSS DSEENAEPDL DDNEEEEEPA VEIEPEPEPQ PQPPPPPQPV
660 670 680 690 700
APAPPPAKKR RGRPPGRTNQ PKQNQPTAII QVEDQNTGAI ENIIVEVKKE
710 720 730
PDAEPAEGEE EEAQAATTDA PNGDLTPEMI LSMMDR
Length:736
Mass (Da):83,745
Last modified:April 23, 2003 - v2
Checksum:i7C49D4A7BDCFEFA1
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti38 – 381C → S in AAC52928. (PubMed:8649389)Curated
Sequence conflicti257 – 2571I → K in AAH37456. (PubMed:15489334)Curated

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U51037 mRNA. Translation: AAC52928.1.
BC037456 mRNA. Translation: AAH37456.1.
BC046398 mRNA. Translation: AAH46398.1.
BC049131 mRNA. Translation: AAH49131.1.
BC058240 mRNA. Translation: AAH58240.1.
AK076192 mRNA. Translation: BAC36245.1.
CCDSiCCDS22606.1.
RefSeqiNP_851839.1. NM_181322.3.
XP_006530711.1. XM_006530648.1.
UniGeneiMm.269474.

Genome annotation databases

EnsembliENSMUST00000005841; ENSMUSP00000005841; ENSMUSG00000005698.
GeneIDi13018.
KEGGimmu:13018.
UCSCiuc009ndm.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U51037 mRNA. Translation: AAC52928.1 .
BC037456 mRNA. Translation: AAH37456.1 .
BC046398 mRNA. Translation: AAH46398.1 .
BC049131 mRNA. Translation: AAH49131.1 .
BC058240 mRNA. Translation: AAH58240.1 .
AK076192 mRNA. Translation: BAC36245.1 .
CCDSi CCDS22606.1.
RefSeqi NP_851839.1. NM_181322.3.
XP_006530711.1. XM_006530648.1.
UniGenei Mm.269474.

3D structure databases

ProteinModelPortali Q61164.
SMRi Q61164. Positions 263-591.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 198963. 21 interactions.
DIPi DIP-38020N.
IntActi Q61164. 14 interactions.
MINTi MINT-4092474.
STRINGi 10090.ENSMUSP00000005841.

Proteomic databases

MaxQBi Q61164.
PaxDbi Q61164.
PRIDEi Q61164.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000005841 ; ENSMUSP00000005841 ; ENSMUSG00000005698 .
GeneIDi 13018.
KEGGi mmu:13018.
UCSCi uc009ndm.2. mouse.

Organism-specific databases

CTDi 10664.
MGIi MGI:109447. Ctcf.

Phylogenomic databases

eggNOGi COG5048.
GeneTreei ENSGT00530000063079.
HOGENOMi HOG000276534.
HOVERGENi HBG000350.
InParanoidi Q61164.
OMAi PPNQADG.
OrthoDBi EOG71K632.
PhylomeDBi Q61164.
TreeFami TF106430.

Miscellaneous databases

ChiTaRSi CTCF. mouse.
NextBioi 282878.
PROi Q61164.
SOURCEi Search...

Gene expression databases

Bgeei Q61164.
CleanExi MM_CTCF.
ExpressionAtlasi Q61164. baseline and differential.
Genevestigatori Q61164.

Family and domain databases

Gene3Di 3.30.160.60. 9 hits.
InterProi IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view ]
Pfami PF00096. zf-C2H2. 1 hit.
[Graphical view ]
SMARTi SM00355. ZnF_C2H2. 11 hits.
[Graphical view ]
PROSITEi PS00028. ZINC_FINGER_C2H2_1. 8 hits.
PS50157. ZINC_FINGER_C2H2_2. 11 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "An exceptionally conserved transcriptional repressor, CTCF, employs different combinations of zinc fingers to bind diverged promoter sequences of avian and mammalian c-myc oncogenes."
    Filippova G.N., Fagerlie S., Klenova E.M., Myers C., Dehner Y., Goodwin G., Neiman P.E., Collins S.J., Lobanenkov V.V.
    Mol. Cell. Biol. 16:2802-2813(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], SUBCELLULAR LOCATION.
    Strain: BDF1.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Brain, Mammary gland and Olfactory epithelium.
  3. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-201.
    Strain: C57BL/6J.
    Tissue: Extraembryonic tissue and Placenta.
  4. "CTCF, a candidate trans-acting factor for X-inactivation choice."
    Chao W., Huynh K.D., Spencer R.J., Davidow L.S., Lee J.T.
    Science 295:345-347(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
  5. "Boundaries between chromosomal domains of X inactivation and escape bind CTCF and lack CpG methylation during early development."
    Filippova G.N., Cheng M.K., Moore J.M., Truong J.-P., Hu Y.J., Nguyen D.K., Tsuchiya K.D., Disteche C.M.
    Dev. Cell 8:31-42(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
  6. "CTCF mediates long-range chromatin looping and local histone modification in the beta-globin locus."
    Splinter E., Heath H., Kooren J., Palstra R.-J., Klous P., Grosveld F., Galjart N., de Laat W.
    Genes Dev. 20:2349-2354(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
  7. "CTCF-dependent chromatin insulator is linked to epigenetic remodeling."
    Ishihara K., Oshimura M., Nakao M.
    Mol. Cell 23:733-742(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH CHD8.
  8. "CTCF mediates interchromosomal colocalization between Igf2/H19 and Wsb1/Nf1."
    Ling J.Q., Li T., Hu J.F., Vu T.H., Chen H.L., Qiu X.W., Cherry A.M., Hoffman A.R.
    Science 312:269-272(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
  9. "CTCF regulates asynchronous replication of the imprinted H19/Igf2 domain."
    Bergstroem R., Whitehead J., Kurukuti S., Ohlsson R.
    Cell Cycle 6:450-454(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
  10. "Evidence that homologous X-chromosome pairing requires transcription and Ctcf protein."
    Xu N., Donohoe M.E., Silva S.S., Lee J.T.
    Nat. Genet. 39:1390-1396(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
  11. "Maternal depletion of CTCF reveals multiple functions during oocyte and preimplantation embryo development."
    Wan L.-B., Pan H., Hannenhalli S., Cheng Y., Ma J., Fedoriw A., Lobanenkov V., Latham K.E., Schultz R.M., Bartolomei M.S.
    Development 135:2729-2738(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
  12. "The CTCF insulator protein is posttranslationally modified by SUMO."
    MacPherson M.J., Beatty L.G., Zhou W., Du M., Sadowski P.D.
    Mol. Cell. Biol. 29:714-725(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUMOYLATION AT LYS-74 AND LYS-698, MUTAGENESIS OF LYS-74 AND LYS-698.

Entry informationi

Entry nameiCTCF_MOUSE
AccessioniPrimary (citable) accession number: Q61164
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 23, 2003
Last sequence update: April 23, 2003
Last modified: October 29, 2014
This is version 127 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3