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Protein

Type I iodothyronine deiodinase

Gene

Dio1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Responsible for the deiodination of T4 (3,5,3',5'-tetraiodothyronine) into T3 (3,5,3'-triiodothyronine) and of T3 into T2 (3,3'-diiodothyronine).

Catalytic activityi

3,5,3'-triiodo-L-thyronine + iodide + A + H+ = L-thyroxine + AH2.PROSITE-ProRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei1261

GO - Molecular functioni

  • selenium binding Source: MGI
  • thyroxine 5'-deiodinase activity Source: UniProtKB

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase
Biological processThyroid hormones biosynthesis

Enzyme and pathway databases

BioCyciMetaCyc:MONOMER-16138.
BRENDAi1.97.1.10. 3474.
SABIO-RKiQ61153.

Names & Taxonomyi

Protein namesi
Recommended name:
Type I iodothyronine deiodinase (EC:1.21.99.4)
Alternative name(s):
5DI
DIOI
Type 1 DI
Type-I 5'-deiodinase
Gene namesi
Name:Dio1
Synonyms:Itdi1, Txdi1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Unplaced

Organism-specific databases

MGIiMGI:94896. Dio1.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei13 – 33HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001543121 – 257Type I iodothyronine deiodinaseAdd BLAST257

Proteomic databases

MaxQBiQ61153.
PaxDbiQ61153.
PRIDEiQ61153.

PTM databases

iPTMnetiQ61153.
PhosphoSitePlusiQ61153.

Expressioni

Gene expression databases

CleanExiMM_DIO1.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000081007.

Structurei

3D structure databases

ProteinModelPortaliQ61153.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the iodothyronine deiodinase family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IWHX. Eukaryota.
ENOG4112999. LUCA.
HOGENOMiHOG000169547.
HOVERGENiHBG000099.
InParanoidiQ61153.
KOiK01562.
PhylomeDBiQ61153.
TreeFamiTF329721.

Family and domain databases

InterProiView protein in InterPro
IPR000643. Iodothyronine_deiodinase.
IPR008261. Iodothyronine_deiodinase_AS.
IPR027252. Iodothyronine_deiodinase_I/III.
IPR036249. Thioredoxin-like_sf.
PANTHERiPTHR11781. PTHR11781. 1 hit.
PfamiView protein in Pfam
PF00837. T4_deiodinase. 1 hit.
PIRSFiPIRSF001330. IOD. 1 hit.
PIRSF500144. IODI_III. 1 hit.
SUPFAMiSSF52833. SSF52833. 1 hit.
PROSITEiView protein in PROSITE
PS01205. T4_DEIODINASE. 1 hit.

Sequencei

Sequence statusi: Complete.

Q61153-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGLPQLWLWL KRLVIFLQVA LEVAVGKVLM TLFPGRVKQS ILAMGQKTGM
60 70 80 90 100
ARNPRFAPDN WVPTFFSIQY FWFVLKVRWQ RLEDRAEFGG LAPNCTVVCL
110 120 130 140 150
SGQKCNIWDF IQGSRPLVLN FGSCTUPSFL LKFDQFKRLV DDFASTADFL
160 170 180 190 200
IIYIEEAHAT DGWAFKNNVD IRQHRSLQER VRAARLLLAR SPQCPVVVDT
210 220 230 240 250
MQNQSSQLYA ALPERLYVIQ EGRICYKGKA GPWNYNPEEV RAVLEKLCTP

PRHVPQL
Length:257
Mass (Da):29,568
Last modified:February 26, 2008 - v3
Checksum:iDF569BDFF7A4257A
GO

Sequence cautioni

The sequence AAB00228 differs from that shown. Reason: Erroneous termination at position 126. Translated as Sec.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti167N → K in AAB00228 (PubMed:7476994).Curated1
Sequence conflicti171I → V in AAB00228 (PubMed:7476994).Curated1
Sequence conflicti186L → M in AAB00228 (PubMed:7476994).Curated1
Sequence conflicti186L → M in AAH89608 (PubMed:15489334).Curated1
Sequence conflicti193Q → R in AAH19786 (PubMed:15489334).Curated1
Sequence conflicti225C → R in AAH19786 (PubMed:15489334).Curated1
Sequence conflicti240V → L in AAB00228 (PubMed:7476994).Curated1

Non-standard residue

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Non-standard residuei126Selenocysteine1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U49861 mRNA. Translation: AAB00228.1. Sequence problems.
BC019786 mRNA. Translation: AAH19786.1.
BC089608 mRNA. Translation: AAH89608.1.
CCDSiCCDS18436.1.
RefSeqiNP_031886.3. NM_007860.4.
UniGeneiMm.148342.

Genome annotation databases

GeneIDi13370.
KEGGimmu:13370.
UCSCiuc008tzq.1. mouse.

Keywords - Coding sequence diversityi

Selenocysteine

Similar proteinsi

Entry informationi

Entry nameiIOD1_MOUSE
AccessioniPrimary (citable) accession number: Q61153
Secondary accession number(s): Q05CY5, Q5FW63
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: February 26, 2008
Last modified: October 25, 2017
This is version 130 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families