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Q61153

- IOD1_MOUSE

UniProt

Q61153 - IOD1_MOUSE

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Protein

Type I iodothyronine deiodinase

Gene

Dio1

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli

Functioni

Responsible for the deiodination of T4 (3,5,3',5'-tetraiodothyronine) into T3 (3,5,3'-triiodothyronine) and of T3 into T2 (3,3'-diiodothyronine).

Catalytic activityi

3,5,3'-triiodo-L-thyronine + iodide + A + H+ = L-thyroxine + AH2.PROSITE-ProRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei126 – 1261

GO - Molecular functioni

  1. selenium binding Source: MGI
  2. thyroxine 5'-deiodinase activity Source: UniProtKB

GO - Biological processi

  1. hormone biosynthetic process Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Thyroid hormones biosynthesis

Enzyme and pathway databases

BioCyciMetaCyc:MONOMER-16138.
ReactomeiREACT_210325. Regulation of thyroid hormone activity.
SABIO-RKQ61153.

Names & Taxonomyi

Protein namesi
Recommended name:
Type I iodothyronine deiodinase (EC:1.97.1.10)
Alternative name(s):
5DI
DIOI
Type 1 DI
Type-I 5'-deiodinase
Gene namesi
Name:Dio1
Synonyms:Itdi1, Txdi1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 4

Organism-specific databases

MGIiMGI:94896. Dio1.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei13 – 3321HelicalSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. endoplasmic reticulum Source: UniProtKB-KW
  2. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 257257Type I iodothyronine deiodinasePRO_0000154312Add
BLAST

Proteomic databases

MaxQBiQ61153.
PaxDbiQ61153.
PRIDEiQ61153.

Expressioni

Gene expression databases

BgeeiQ61153.
CleanExiMM_DIO1.
ExpressionAtlasiQ61153. baseline and differential.
GenevestigatoriQ61153.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000081007.

Structurei

3D structure databases

ProteinModelPortaliQ61153.
SMRiQ61153. Positions 85-246.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the iodothyronine deiodinase family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG67608.
GeneTreeiENSGT00730000110840.
HOGENOMiHOG000169547.
HOVERGENiHBG000099.
InParanoidiQ61153.
KOiK01562.
OrthoDBiEOG751NHS.
PhylomeDBiQ61153.
TreeFamiTF329721.

Family and domain databases

Gene3Di3.40.30.10. 1 hit.
InterProiIPR000643. Iodothyronine_deiodinase.
IPR008261. Iodothyronine_deiodinase_AS.
IPR027252. Iodothyronine_deiodinase_I/III.
IPR012336. Thioredoxin-like_fold.
[Graphical view]
PANTHERiPTHR11781. PTHR11781. 1 hit.
PfamiPF00837. T4_deiodinase. 1 hit.
[Graphical view]
PIRSFiPIRSF001330. IOD. 1 hit.
PIRSF500144. IODI_III. 1 hit.
SUPFAMiSSF52833. SSF52833. 1 hit.
PROSITEiPS01205. T4_DEIODINASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q61153-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MGLPQLWLWL KRLVIFLQVA LEVAVGKVLM TLFPGRVKQS ILAMGQKTGM
60 70 80 90 100
ARNPRFAPDN WVPTFFSIQY FWFVLKVRWQ RLEDRAEFGG LAPNCTVVCL
110 120 130 140 150
SGQKCNIWDF IQGSRPLVLN FGSCTUPSFL LKFDQFKRLV DDFASTADFL
160 170 180 190 200
IIYIEEAHAT DGWAFKNNVD IRQHRSLQER VRAARLLLAR SPQCPVVVDT
210 220 230 240 250
MQNQSSQLYA ALPERLYVIQ EGRICYKGKA GPWNYNPEEV RAVLEKLCTP

PRHVPQL
Length:257
Mass (Da):29,568
Last modified:February 26, 2008 - v3
Checksum:iDF569BDFF7A4257A
GO

Sequence cautioni

The sequence AAB00228.1 differs from that shown. Reason: Erroneous termination at position 126. Translated as Sec.Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti167 – 1671N → K in AAB00228. (PubMed:7476994)Curated
Sequence conflicti171 – 1711I → V in AAB00228. (PubMed:7476994)Curated
Sequence conflicti186 – 1861L → M in AAB00228. (PubMed:7476994)Curated
Sequence conflicti186 – 1861L → M in AAH89608. (PubMed:15489334)Curated
Sequence conflicti193 – 1931Q → R in AAH19786. (PubMed:15489334)Curated
Sequence conflicti225 – 2251C → R in AAH19786. (PubMed:15489334)Curated
Sequence conflicti240 – 2401V → L in AAB00228. (PubMed:7476994)Curated

Non-standard residue

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Non-standard residuei126 – 1261Selenocysteine

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U49861 mRNA. Translation: AAB00228.1. Sequence problems.
BC019786 mRNA. Translation: AAH19786.1.
BC089608 mRNA. Translation: AAH89608.1.
CCDSiCCDS18436.1.
RefSeqiNP_031886.3. NM_007860.3.
UniGeneiMm.148342.

Genome annotation databases

EnsembliENSMUST00000082426; ENSMUSP00000081007; ENSMUSG00000034785.
ENSMUST00000150974; ENSMUSP00000117751; ENSMUSG00000034785.
GeneIDi13370.
KEGGimmu:13370.
UCSCiuc008tzq.1. mouse.

Keywords - Coding sequence diversityi

Selenocysteine

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U49861 mRNA. Translation: AAB00228.1 . Sequence problems.
BC019786 mRNA. Translation: AAH19786.1 .
BC089608 mRNA. Translation: AAH89608.1 .
CCDSi CCDS18436.1.
RefSeqi NP_031886.3. NM_007860.3.
UniGenei Mm.148342.

3D structure databases

ProteinModelPortali Q61153.
SMRi Q61153. Positions 85-246.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 10090.ENSMUSP00000081007.

Proteomic databases

MaxQBi Q61153.
PaxDbi Q61153.
PRIDEi Q61153.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000082426 ; ENSMUSP00000081007 ; ENSMUSG00000034785 .
ENSMUST00000150974 ; ENSMUSP00000117751 ; ENSMUSG00000034785 .
GeneIDi 13370.
KEGGi mmu:13370.
UCSCi uc008tzq.1. mouse.

Organism-specific databases

CTDi 1733.
MGIi MGI:94896. Dio1.

Phylogenomic databases

eggNOGi NOG67608.
GeneTreei ENSGT00730000110840.
HOGENOMi HOG000169547.
HOVERGENi HBG000099.
InParanoidi Q61153.
KOi K01562.
OrthoDBi EOG751NHS.
PhylomeDBi Q61153.
TreeFami TF329721.

Enzyme and pathway databases

BioCyci MetaCyc:MONOMER-16138.
Reactomei REACT_210325. Regulation of thyroid hormone activity.
SABIO-RK Q61153.

Miscellaneous databases

ChiTaRSi Dio1. mouse.
NextBioi 283716.
PROi Q61153.
SOURCEi Search...

Gene expression databases

Bgeei Q61153.
CleanExi MM_DIO1.
ExpressionAtlasi Q61153. baseline and differential.
Genevestigatori Q61153.

Family and domain databases

Gene3Di 3.40.30.10. 1 hit.
InterProi IPR000643. Iodothyronine_deiodinase.
IPR008261. Iodothyronine_deiodinase_AS.
IPR027252. Iodothyronine_deiodinase_I/III.
IPR012336. Thioredoxin-like_fold.
[Graphical view ]
PANTHERi PTHR11781. PTHR11781. 1 hit.
Pfami PF00837. T4_deiodinase. 1 hit.
[Graphical view ]
PIRSFi PIRSF001330. IOD. 1 hit.
PIRSF500144. IODI_III. 1 hit.
SUPFAMi SSF52833. SSF52833. 1 hit.
PROSITEi PS01205. T4_DEIODINASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Structural and functional differences in the dio1 gene in mice with inherited type 1 deiodinase deficiency."
    Maia A.L., Berry M.J., Sabbag R., Harney J.W., Larsen P.R.
    Mol. Endocrinol. 9:969-980(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: C57BL/6J.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: FVB/N.
    Tissue: Liver.

Entry informationi

Entry nameiIOD1_MOUSE
AccessioniPrimary (citable) accession number: Q61153
Secondary accession number(s): Q05CY5, Q5FW63
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: February 26, 2008
Last modified: November 26, 2014
This is version 112 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3