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Q61153 (IOD1_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified May 1, 2013. Version 97. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Type I iodothyronine deiodinase
EC=1.97.1.10
Alternative name(s):
5DI
DIOI
Type 1 DI
Type-I 5'-deiodinase
Gene names
Name:Dio1
Synonyms:Itdi1, Txdi1
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length257 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Responsible for the deiodination of T4 (3,5,3',5'-tetraiodothyronine) into T3 (3,5,3'-triiodothyronine) and of T3 into T2 (3,3'-diiodothyronine).

Catalytic activity

3,5,3'-triiodo-L-thyronine + iodide + A + H+ = L-thyroxine + AH2.

Subcellular location

Endoplasmic reticulum membrane; Single-pass membrane protein By similarity.

Sequence similarities

Belongs to the iodothyronine deiodinase family.

Sequence caution

The sequence AAB00228.1 differs from that shown. Reason: Erroneous termination at position 126. Translated as Sec.

Ontologies

Keywords
   Biological processThyroid hormones biosynthesis
   Cellular componentEndoplasmic reticulum
Membrane
   Coding sequence diversitySelenocysteine
   DomainTransmembrane
Transmembrane helix
   Molecular functionOxidoreductase
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processhormone biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular_componentendoplasmic reticulum membrane

Inferred from electronic annotation. Source: UniProtKB-SubCell

integral to membrane

Inferred from electronic annotation. Source: UniProtKB-KW

   Molecular_functionselenium binding

Inferred from direct assay PubMed 8419134. Source: MGI

thyroxine 5'-deiodinase activity

Inferred from direct assay PubMed 12586753. Source: UniProtKB

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 257257Type I iodothyronine deiodinase
PRO_0000154312

Regions

Transmembrane13 – 3321Helical; Potential

Sites

Active site1261

Amino acid modifications

Non-standard residue1261Selenocysteine

Experimental info

Sequence conflict1671N → K in AAB00228. Ref.1
Sequence conflict1711I → V in AAB00228. Ref.1
Sequence conflict1861L → M in AAB00228. Ref.1
Sequence conflict1861L → M in AAH89608. Ref.2
Sequence conflict1931Q → R in AAH19786. Ref.2
Sequence conflict2251C → R in AAH19786. Ref.2
Sequence conflict2401V → L in AAB00228. Ref.1

Sequences

Sequence LengthMass (Da)Tools
Q61153 [UniParc].

Last modified February 26, 2008. Version 3.
Checksum: DF569BDFF7A4257A

FASTA25729,568
        10         20         30         40         50         60 
MGLPQLWLWL KRLVIFLQVA LEVAVGKVLM TLFPGRVKQS ILAMGQKTGM ARNPRFAPDN 

        70         80         90        100        110        120 
WVPTFFSIQY FWFVLKVRWQ RLEDRAEFGG LAPNCTVVCL SGQKCNIWDF IQGSRPLVLN 

       130        140        150        160        170        180 
FGSCTUPSFL LKFDQFKRLV DDFASTADFL IIYIEEAHAT DGWAFKNNVD IRQHRSLQER 

       190        200        210        220        230        240 
VRAARLLLAR SPQCPVVVDT MQNQSSQLYA ALPERLYVIQ EGRICYKGKA GPWNYNPEEV 

       250 
RAVLEKLCTP PRHVPQL

« Hide

References

« Hide 'large scale' references
[1]"Structural and functional differences in the dio1 gene in mice with inherited type 1 deiodinase deficiency."
Maia A.L., Berry M.J., Sabbag R., Harney J.W., Larsen P.R.
Mol. Endocrinol. 9:969-980(1995) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Strain: C57BL/6J.
[2]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: FVB/N.
Tissue: Liver.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		U49861 mRNA. Translation: AAB00228.1. Sequence problems.
BC019786 mRNA. Translation: AAH19786.1.
BC089608 mRNA. Translation: AAH89608.1.
IPIIPI00117862.
RefSeqNP_031886.3. NM_007860.3.
UniGeneMm.148342.

3D structure databases

ProteinModelPortalQ61153.
ModBaseSearch...

Protein-protein interaction databases

STRING10090.ENSMUSP00000081007.

Proteomic databases

PaxDbQ61153.
PRIDEQ61153.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000082426; ENSMUSP00000081007; ENSMUSG00000034785.
ENSMUST00000150974; ENSMUSP00000117751; ENSMUSG00000034785.
GeneID13370.
KEGGmmu:13370.
UCSCuc008tzq.1. mouse.

Organism-specific databases

CTD1733.
MGIMGI:94896. Dio1.

Phylogenomic databases

eggNOGNOG67608.
GeneTreeENSGT00680000100107.
HOGENOMHOG000169547.
HOVERGENHBG000099.
InParanoidQ61153.
KOK01562.
OrthoDBEOG40K80M.

Enzyme and pathway databases

BioCycMetaCyc:MONOMER-16138.
SABIO-RKQ61153.

Gene expression databases

ArrayExpressQ61153.
BgeeQ61153.
CleanExMM_DIO1.
GenevestigatorQ61153.
GermOnlineENSMUSG00000034785. Mus musculus.

Family and domain databases

Gene3D3.40.30.10. 1 hit.
InterProIPR000643. Iodothyronine_deiodinase.
IPR008261. Iodothyronine_deiodinase_AS.
IPR027252. Iodothyronine_deiodinase_I/III.
IPR012336. Thioredoxin-like_fold.
[Graphical view]
PANTHERPTHR11781. PTHR11781. 1 hit.
PfamPF00837. T4_deiodinase. 1 hit.
[Graphical view]
PIRSFPIRSF001330. IOD. 1 hit.
PIRSF500144. IODI_III. 1 hit.
PROSITEPS01205. T4_DEIODINASE. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio283716.
SOURCESearch...

Entry information

Entry nameIOD1_MOUSE
AccessionPrimary (citable) accession number: Q61153
Secondary accession number(s): Q05CY5, Q5FW63
Entry history
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: February 26, 2008
Last modified: May 1, 2013
This is version 97 of the entry and version 3 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

SIMILARITY comments

Index of protein domains and families

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