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Q61153

- IOD1_MOUSE

UniProt

Q61153 - IOD1_MOUSE

Protein

Type I iodothyronine deiodinase

Gene

Dio1

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 110 (01 Oct 2014)
      Sequence version 3 (26 Feb 2008)
      Previous versions | rss
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    Functioni

    Responsible for the deiodination of T4 (3,5,3',5'-tetraiodothyronine) into T3 (3,5,3'-triiodothyronine) and of T3 into T2 (3,3'-diiodothyronine).

    Catalytic activityi

    3,5,3'-triiodo-L-thyronine + iodide + A + H+ = L-thyroxine + AH2.PROSITE-ProRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei126 – 1261

    GO - Molecular functioni

    1. selenium binding Source: MGI
    2. thyroxine 5'-deiodinase activity Source: UniProtKB

    GO - Biological processi

    1. hormone biosynthetic process Source: UniProtKB-KW

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Biological processi

    Thyroid hormones biosynthesis

    Enzyme and pathway databases

    BioCyciMetaCyc:MONOMER-16138.
    ReactomeiREACT_210325. Regulation of thyroid hormone activity.
    SABIO-RKQ61153.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Type I iodothyronine deiodinase (EC:1.97.1.10)
    Alternative name(s):
    5DI
    DIOI
    Type 1 DI
    Type-I 5'-deiodinase
    Gene namesi
    Name:Dio1
    Synonyms:Itdi1, Txdi1
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 4

    Organism-specific databases

    MGIiMGI:94896. Dio1.

    Subcellular locationi

    GO - Cellular componenti

    1. endoplasmic reticulum membrane Source: UniProtKB-SubCell
    2. integral component of membrane Source: UniProtKB-KW

    Keywords - Cellular componenti

    Endoplasmic reticulum, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 257257Type I iodothyronine deiodinasePRO_0000154312Add
    BLAST

    Proteomic databases

    MaxQBiQ61153.
    PaxDbiQ61153.
    PRIDEiQ61153.

    Expressioni

    Gene expression databases

    ArrayExpressiQ61153.
    BgeeiQ61153.
    CleanExiMM_DIO1.
    GenevestigatoriQ61153.

    Interactioni

    Protein-protein interaction databases

    STRINGi10090.ENSMUSP00000081007.

    Structurei

    3D structure databases

    ProteinModelPortaliQ61153.
    ModBaseiSearch...
    MobiDBiSearch...

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei13 – 3321HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the iodothyronine deiodinase family.Curated

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG67608.
    GeneTreeiENSGT00740000115645.
    HOGENOMiHOG000169547.
    HOVERGENiHBG000099.
    InParanoidiQ61153.
    KOiK01562.
    OrthoDBiEOG751NHS.
    PhylomeDBiQ61153.
    TreeFamiTF329721.

    Family and domain databases

    Gene3Di3.40.30.10. 1 hit.
    InterProiIPR000643. Iodothyronine_deiodinase.
    IPR008261. Iodothyronine_deiodinase_AS.
    IPR027252. Iodothyronine_deiodinase_I/III.
    IPR012336. Thioredoxin-like_fold.
    [Graphical view]
    PANTHERiPTHR11781. PTHR11781. 1 hit.
    PfamiPF00837. T4_deiodinase. 1 hit.
    [Graphical view]
    PIRSFiPIRSF001330. IOD. 1 hit.
    PIRSF500144. IODI_III. 1 hit.
    SUPFAMiSSF52833. SSF52833. 1 hit.
    PROSITEiPS01205. T4_DEIODINASE. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q61153-1 [UniParc]FASTAAdd to Basket

    « Hide

    MGLPQLWLWL KRLVIFLQVA LEVAVGKVLM TLFPGRVKQS ILAMGQKTGM    50
    ARNPRFAPDN WVPTFFSIQY FWFVLKVRWQ RLEDRAEFGG LAPNCTVVCL 100
    SGQKCNIWDF IQGSRPLVLN FGSCTUPSFL LKFDQFKRLV DDFASTADFL 150
    IIYIEEAHAT DGWAFKNNVD IRQHRSLQER VRAARLLLAR SPQCPVVVDT 200
    MQNQSSQLYA ALPERLYVIQ EGRICYKGKA GPWNYNPEEV RAVLEKLCTP 250
    PRHVPQL 257
    Length:257
    Mass (Da):29,568
    Last modified:February 26, 2008 - v3
    Checksum:iDF569BDFF7A4257A
    GO

    Sequence cautioni

    The sequence AAB00228.1 differs from that shown. Reason: Erroneous termination at position 126. Translated as Sec.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti167 – 1671N → K in AAB00228. (PubMed:7476994)Curated
    Sequence conflicti171 – 1711I → V in AAB00228. (PubMed:7476994)Curated
    Sequence conflicti186 – 1861L → M in AAB00228. (PubMed:7476994)Curated
    Sequence conflicti186 – 1861L → M in AAH89608. (PubMed:15489334)Curated
    Sequence conflicti193 – 1931Q → R in AAH19786. (PubMed:15489334)Curated
    Sequence conflicti225 – 2251C → R in AAH19786. (PubMed:15489334)Curated
    Sequence conflicti240 – 2401V → L in AAB00228. (PubMed:7476994)Curated

    Non-standard residue

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Non-standard residuei126 – 1261Selenocysteine

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U49861 mRNA. Translation: AAB00228.1. Sequence problems.
    BC019786 mRNA. Translation: AAH19786.1.
    BC089608 mRNA. Translation: AAH89608.1.
    CCDSiCCDS18436.1.
    RefSeqiNP_031886.3. NM_007860.3.
    UniGeneiMm.148342.

    Genome annotation databases

    EnsembliENSMUST00000082426; ENSMUSP00000081007; ENSMUSG00000034785.
    ENSMUST00000150974; ENSMUSP00000117751; ENSMUSG00000034785.
    GeneIDi13370.
    KEGGimmu:13370.
    UCSCiuc008tzq.1. mouse.

    Keywords - Coding sequence diversityi

    Selenocysteine

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U49861 mRNA. Translation: AAB00228.1 . Sequence problems.
    BC019786 mRNA. Translation: AAH19786.1 .
    BC089608 mRNA. Translation: AAH89608.1 .
    CCDSi CCDS18436.1.
    RefSeqi NP_031886.3. NM_007860.3.
    UniGenei Mm.148342.

    3D structure databases

    ProteinModelPortali Q61153.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 10090.ENSMUSP00000081007.

    Proteomic databases

    MaxQBi Q61153.
    PaxDbi Q61153.
    PRIDEi Q61153.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000082426 ; ENSMUSP00000081007 ; ENSMUSG00000034785 .
    ENSMUST00000150974 ; ENSMUSP00000117751 ; ENSMUSG00000034785 .
    GeneIDi 13370.
    KEGGi mmu:13370.
    UCSCi uc008tzq.1. mouse.

    Organism-specific databases

    CTDi 1733.
    MGIi MGI:94896. Dio1.

    Phylogenomic databases

    eggNOGi NOG67608.
    GeneTreei ENSGT00740000115645.
    HOGENOMi HOG000169547.
    HOVERGENi HBG000099.
    InParanoidi Q61153.
    KOi K01562.
    OrthoDBi EOG751NHS.
    PhylomeDBi Q61153.
    TreeFami TF329721.

    Enzyme and pathway databases

    BioCyci MetaCyc:MONOMER-16138.
    Reactomei REACT_210325. Regulation of thyroid hormone activity.
    SABIO-RK Q61153.

    Miscellaneous databases

    NextBioi 283716.
    PROi Q61153.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q61153.
    Bgeei Q61153.
    CleanExi MM_DIO1.
    Genevestigatori Q61153.

    Family and domain databases

    Gene3Di 3.40.30.10. 1 hit.
    InterProi IPR000643. Iodothyronine_deiodinase.
    IPR008261. Iodothyronine_deiodinase_AS.
    IPR027252. Iodothyronine_deiodinase_I/III.
    IPR012336. Thioredoxin-like_fold.
    [Graphical view ]
    PANTHERi PTHR11781. PTHR11781. 1 hit.
    Pfami PF00837. T4_deiodinase. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF001330. IOD. 1 hit.
    PIRSF500144. IODI_III. 1 hit.
    SUPFAMi SSF52833. SSF52833. 1 hit.
    PROSITEi PS01205. T4_DEIODINASE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Structural and functional differences in the dio1 gene in mice with inherited type 1 deiodinase deficiency."
      Maia A.L., Berry M.J., Sabbag R., Harney J.W., Larsen P.R.
      Mol. Endocrinol. 9:969-980(1995) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: C57BL/6J.
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: FVB/N.
      Tissue: Liver.

    Entry informationi

    Entry nameiIOD1_MOUSE
    AccessioniPrimary (citable) accession number: Q61153
    Secondary accession number(s): Q05CY5, Q5FW63
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 15, 1998
    Last sequence update: February 26, 2008
    Last modified: October 1, 2014
    This is version 110 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3