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Q61152

- PTN18_MOUSE

UniProt

Q61152 - PTN18_MOUSE

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Protein

Tyrosine-protein phosphatase non-receptor type 18

Gene

Ptpn18

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

May be involved in growth and differentiation of hematopoietic cells.

Catalytic activityi

Protein tyrosine phosphate + H2O = protein tyrosine + phosphate.PROSITE-ProRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei197 – 1971SubstrateBy similarity
Active sitei229 – 2291Phosphocysteine intermediatePROSITE-ProRule annotation
Binding sitei276 – 2761SubstrateBy similarity

GO - Molecular functioni

  1. non-membrane spanning protein tyrosine phosphatase activity Source: MGI

GO - Biological processi

  1. peptidyl-tyrosine dephosphorylation Source: GOC
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protein phosphatase

Names & Taxonomyi

Protein namesi
Recommended name:
Tyrosine-protein phosphatase non-receptor type 18 (EC:3.1.3.48)
Alternative name(s):
Fetal liver phosphatase 1
Short name:
FLP-1
PTP-K1
Gene namesi
Name:Ptpn18
Synonyms:Flp1, Ptpk1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 1

Organism-specific databases

MGIiMGI:108410. Ptpn18.

Subcellular locationi

Nucleus 1 Publication. Cytoplasm 1 Publication

GO - Cellular componenti

  1. cytoplasm Source: MGI
  2. nucleus Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 453453Tyrosine-protein phosphatase non-receptor type 18PRO_0000094774Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei381 – 3811Phosphotyrosine2 Publications
Modified residuei419 – 4191Phosphotyrosine1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ61152.
PaxDbiQ61152.
PRIDEiQ61152.

PTM databases

PhosphoSiteiQ61152.

Miscellaneous databases

PMAP-CutDBQ61152.

Expressioni

Tissue specificityi

Highest expression in bone marrow. Also expressed in kidney, lung, ovary, spleen, thymus and lymph node.3 Publications

Developmental stagei

Expressed in the embryo from day 15.5.

Gene expression databases

BgeeiQ61152.
ExpressionAtlasiQ61152. baseline and differential.
GenevestigatoriQ61152.

Interactioni

Subunit structurei

Interacts with PSTPIP1.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
Pstpip1P978143EBI-7074223,EBI-7484574
Pstpip2Q99M157EBI-7074223,EBI-8653964

Protein-protein interaction databases

IntActiQ61152. 2 interactions.
MINTiMINT-157346.
STRINGi10090.ENSMUSP00000027302.

Structurei

3D structure databases

ProteinModelPortaliQ61152.
SMRiQ61152. Positions 25-292.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini26 – 291266Tyrosine-protein phosphatasePROSITE-ProRule annotationAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni229 – 2357Substrate bindingBy similarity

Sequence similaritiesi

Contains 1 tyrosine-protein phosphatase domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiCOG5599.
GeneTreeiENSGT00760000118836.
HOGENOMiHOG000115776.
HOVERGENiHBG053419.
InParanoidiQ61152.
KOiK18024.
OMAiNCAPLYD.
OrthoDBiEOG744T8Z.
PhylomeDBiQ61152.
TreeFamiTF351977.

Family and domain databases

Gene3Di3.90.190.10. 1 hit.
InterProiIPR029021. Prot-tyrosine_phosphatase-like.
IPR000387. Tyr/Dual-sp_Pase.
IPR016130. Tyr_Pase_AS.
IPR000242. Tyr_Pase_rcpt/non-rcpt.
[Graphical view]
PfamiPF00102. Y_phosphatase. 1 hit.
[Graphical view]
PRINTSiPR00700. PRTYPHPHTASE.
SMARTiSM00194. PTPc. 1 hit.
[Graphical view]
SUPFAMiSSF52799. SSF52799. 1 hit.
PROSITEiPS00383. TYR_PHOSPHATASE_1. 1 hit.
PS50056. TYR_PHOSPHATASE_2. 1 hit.
PS50055. TYR_PHOSPHATASE_PTP. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q61152-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSRHTDLVRS FLEQLEARDY REGAILAREF SDIKARSVAW KSEGVCSTKA
60 70 80 90 100
GSRLGNTNKN RYKDVVAYDE TRVILSLLQE EGHGDYINAN FIRGIDGSQA
110 120 130 140 150
YIATQGPLPH TLLDFWRLVW EFGVKVILMA CQETENGRRK CERYWAREQE
160 170 180 190 200
PLKAGPFCIT LTKETTLNAD ITLRTLQVTF QKEFRSVHQL QYMSWPDHGV
210 220 230 240 250
PSSSDHILTM VEEARCLQGL GPGPLCVHCS AGCGRTGVLC AVDYVRQLLL
260 270 280 290 300
TQTIPPNFSL FQVVLEMRKQ RPAAVQTEEQ YRFLYHTVAQ LFSRTLQDTS
310 320 330 340 350
PHYQNLKENC APICKEAFSL RTSSALPATS RPPGGVLRSI SVPAPPTLPM
360 370 380 390 400
ADTYAVVQKR GASAGTGPGP RAPTSTDTPI YSQVAPRAQR PVAHTEDAQG
410 420 430 440 450
TTALRRVPAD QNSSGPDAYE EVTDGAQTGG LGFNLRIGRP KGPRDPPAEW

TRV
Length:453
Mass (Da):50,202
Last modified:November 1, 1996 - v1
Checksum:i88AD7E73CE8136B0
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti11 – 111F → L in AAC52991. (PubMed:8977243)Curated
Sequence conflicti57 – 571T → M in AAH08512. (PubMed:15489334)Curated
Sequence conflicti95 – 951I → T in AAH08512. (PubMed:15489334)Curated
Sequence conflicti184 – 1841F → S in AAH08512. (PubMed:15489334)Curated
Sequence conflicti362 – 3687ASAGTGP → LRRHRA in AAC52991. (PubMed:8977243)Curated
Sequence conflicti365 – 3651G → V in AAH08512. (PubMed:15489334)Curated
Sequence conflicti374 – 3741T → N in AAH08512. (PubMed:15489334)Curated
Sequence conflicti401 – 4011T → I in AAH08512. (PubMed:15489334)Curated

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U49853 mRNA. Translation: AAB18623.1.
U35124 mRNA. Translation: AAB82736.1.
U52523 mRNA. Translation: AAC52991.1.
AK144353 mRNA. Translation: BAE25845.1.
BC008512 mRNA. Translation: AAH08512.1.
CCDSiCCDS14867.1.
RefSeqiNP_035336.2. NM_011206.2.
UniGeneiMm.361.

Genome annotation databases

EnsembliENSMUST00000027302; ENSMUSP00000027302; ENSMUSG00000026126.
GeneIDi19253.
KEGGimmu:19253.
UCSCiuc007aos.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U49853 mRNA. Translation: AAB18623.1 .
U35124 mRNA. Translation: AAB82736.1 .
U52523 mRNA. Translation: AAC52991.1 .
AK144353 mRNA. Translation: BAE25845.1 .
BC008512 mRNA. Translation: AAH08512.1 .
CCDSi CCDS14867.1.
RefSeqi NP_035336.2. NM_011206.2.
UniGenei Mm.361.

3D structure databases

ProteinModelPortali Q61152.
SMRi Q61152. Positions 25-292.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

IntActi Q61152. 2 interactions.
MINTi MINT-157346.
STRINGi 10090.ENSMUSP00000027302.

PTM databases

PhosphoSitei Q61152.

Proteomic databases

MaxQBi Q61152.
PaxDbi Q61152.
PRIDEi Q61152.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000027302 ; ENSMUSP00000027302 ; ENSMUSG00000026126 .
GeneIDi 19253.
KEGGi mmu:19253.
UCSCi uc007aos.1. mouse.

Organism-specific databases

CTDi 26469.
MGIi MGI:108410. Ptpn18.

Phylogenomic databases

eggNOGi COG5599.
GeneTreei ENSGT00760000118836.
HOGENOMi HOG000115776.
HOVERGENi HBG053419.
InParanoidi Q61152.
KOi K18024.
OMAi NCAPLYD.
OrthoDBi EOG744T8Z.
PhylomeDBi Q61152.
TreeFami TF351977.

Miscellaneous databases

NextBioi 296096.
PMAP-CutDB Q61152.
PROi Q61152.
SOURCEi Search...

Gene expression databases

Bgeei Q61152.
ExpressionAtlasi Q61152. baseline and differential.
Genevestigatori Q61152.

Family and domain databases

Gene3Di 3.90.190.10. 1 hit.
InterProi IPR029021. Prot-tyrosine_phosphatase-like.
IPR000387. Tyr/Dual-sp_Pase.
IPR016130. Tyr_Pase_AS.
IPR000242. Tyr_Pase_rcpt/non-rcpt.
[Graphical view ]
Pfami PF00102. Y_phosphatase. 1 hit.
[Graphical view ]
PRINTSi PR00700. PRTYPHPHTASE.
SMARTi SM00194. PTPc. 1 hit.
[Graphical view ]
SUPFAMi SSF52799. SSF52799. 1 hit.
PROSITEi PS00383. TYR_PHOSPHATASE_1. 1 hit.
PS50056. TYR_PHOSPHATASE_2. 1 hit.
PS50055. TYR_PHOSPHATASE_PTP. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "A novel protein tyrosine phosphatase expressed in lin(lo)CD34(hi)Sca(hi) hematopoietic progenitor cells."
    Cheng J., Daimaru L., Fennie C., Lasky L.A.
    Blood 88:1156-1167(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
    Tissue: Embryo.
  2. "Cloning and characterization of PTP-K1, a novel nonreceptor protein tyrosine phosphatase highly expressed in bone marrow."
    Huang K., Sommers C.L., Grinberg A., Kozak C.A., Love P.E.
    Oncogene 13:1567-1573(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
    Tissue: Kidney.
  3. "Cloning and characterization of fetal liver phosphatase 1, a nuclear protein tyrosine phosphatase isolated from hematopoietic stem cells."
    Dosil M., Leibman N., Lemischka I.R.
    Blood 88:4510-4525(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
    Strain: C57BL/6.
    Tissue: Fetal liver.
  4. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Intestinal mucosa.
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: Czech II.
    Tissue: Mammary tumor.
  6. "PSTPIP: a tyrosine phosphorylated cleavage furrow-associated protein that is a substrate for a PEST tyrosine phosphatase."
    Spencer S., Dowbenko D., Cheng J., Li W., Brush J., Utzig S., Simanis V., Lasky L.A.
    J. Cell Biol. 138:845-860(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH PSTPIP1.
  7. "Quantitative time-resolved phosphoproteomic analysis of mast cell signaling."
    Cao L., Yu K., Banh C., Nguyen V., Ritz A., Raphael B.J., Kawakami Y., Kawakami T., Salomon A.R.
    J. Immunol. 179:5864-5876(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-381 AND TYR-419, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Mast cell.
  8. "The phagosomal proteome in interferon-gamma-activated macrophages."
    Trost M., English L., Lemieux S., Courcelles M., Desjardins M., Thibault P.
    Immunity 30:143-154(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-381, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiPTN18_MOUSE
AccessioniPrimary (citable) accession number: Q61152
Secondary accession number(s): Q4JFH4, Q62404, Q922E3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 24, 2006
Last sequence update: November 1, 1996
Last modified: October 29, 2014
This is version 110 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3