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Q61152

- PTN18_MOUSE

UniProt

Q61152 - PTN18_MOUSE

Protein

Tyrosine-protein phosphatase non-receptor type 18

Gene

Ptpn18

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 109 (01 Oct 2014)
      Sequence version 1 (01 Nov 1996)
      Previous versions | rss
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    Functioni

    May be involved in growth and differentiation of hematopoietic cells.

    Catalytic activityi

    Protein tyrosine phosphate + H2O = protein tyrosine + phosphate.PROSITE-ProRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei197 – 1971SubstrateBy similarity
    Active sitei229 – 2291Phosphocysteine intermediatePROSITE-ProRule annotation
    Binding sitei276 – 2761SubstrateBy similarity

    GO - Molecular functioni

    1. non-membrane spanning protein tyrosine phosphatase activity Source: MGI
    2. protein binding Source: IntAct

    GO - Biological processi

    1. peptidyl-tyrosine dephosphorylation Source: GOC

    Keywords - Molecular functioni

    Hydrolase, Protein phosphatase

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Tyrosine-protein phosphatase non-receptor type 18 (EC:3.1.3.48)
    Alternative name(s):
    Fetal liver phosphatase 1
    Short name:
    FLP-1
    PTP-K1
    Gene namesi
    Name:Ptpn18
    Synonyms:Flp1, Ptpk1
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 1

    Organism-specific databases

    MGIiMGI:108410. Ptpn18.

    Subcellular locationi

    Nucleus 1 Publication. Cytoplasm 1 Publication

    GO - Cellular componenti

    1. cytoplasm Source: MGI
    2. nucleus Source: MGI

    Keywords - Cellular componenti

    Cytoplasm, Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 453453Tyrosine-protein phosphatase non-receptor type 18PRO_0000094774Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei381 – 3811Phosphotyrosine2 Publications
    Modified residuei419 – 4191Phosphotyrosine1 Publication

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    PaxDbiQ61152.
    PRIDEiQ61152.

    PTM databases

    PhosphoSiteiQ61152.

    Miscellaneous databases

    PMAP-CutDBQ61152.

    Expressioni

    Tissue specificityi

    Highest expression in bone marrow. Also expressed in kidney, lung, ovary, spleen, thymus and lymph node.3 Publications

    Developmental stagei

    Expressed in the embryo from day 15.5.

    Gene expression databases

    BgeeiQ61152.
    GenevestigatoriQ61152.

    Interactioni

    Subunit structurei

    Interacts with PSTPIP1.1 Publication

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    Pstpip1P978143EBI-7074223,EBI-7484574
    Pstpip2Q99M157EBI-7074223,EBI-8653964

    Protein-protein interaction databases

    IntActiQ61152. 2 interactions.
    MINTiMINT-157346.
    STRINGi10090.ENSMUSP00000027302.

    Structurei

    3D structure databases

    ProteinModelPortaliQ61152.
    SMRiQ61152. Positions 25-292.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini26 – 291266Tyrosine-protein phosphatasePROSITE-ProRule annotationAdd
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni229 – 2357Substrate bindingBy similarity

    Sequence similaritiesi

    Contains 1 tyrosine-protein phosphatase domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiCOG5599.
    GeneTreeiENSGT00750000117233.
    HOGENOMiHOG000115776.
    HOVERGENiHBG053419.
    InParanoidiQ61152.
    KOiK18024.
    OMAiNCAPLYD.
    OrthoDBiEOG744T8Z.
    PhylomeDBiQ61152.
    TreeFamiTF351977.

    Family and domain databases

    Gene3Di3.90.190.10. 1 hit.
    InterProiIPR029021. Prot-tyrosine_phosphatase-like.
    IPR000387. Tyr/Dual-sp_Pase.
    IPR016130. Tyr_Pase_AS.
    IPR000242. Tyr_Pase_rcpt/non-rcpt.
    [Graphical view]
    PfamiPF00102. Y_phosphatase. 1 hit.
    [Graphical view]
    PRINTSiPR00700. PRTYPHPHTASE.
    SMARTiSM00194. PTPc. 1 hit.
    [Graphical view]
    SUPFAMiSSF52799. SSF52799. 1 hit.
    PROSITEiPS00383. TYR_PHOSPHATASE_1. 1 hit.
    PS50056. TYR_PHOSPHATASE_2. 1 hit.
    PS50055. TYR_PHOSPHATASE_PTP. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q61152-1 [UniParc]FASTAAdd to Basket

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    MSRHTDLVRS FLEQLEARDY REGAILAREF SDIKARSVAW KSEGVCSTKA    50
    GSRLGNTNKN RYKDVVAYDE TRVILSLLQE EGHGDYINAN FIRGIDGSQA 100
    YIATQGPLPH TLLDFWRLVW EFGVKVILMA CQETENGRRK CERYWAREQE 150
    PLKAGPFCIT LTKETTLNAD ITLRTLQVTF QKEFRSVHQL QYMSWPDHGV 200
    PSSSDHILTM VEEARCLQGL GPGPLCVHCS AGCGRTGVLC AVDYVRQLLL 250
    TQTIPPNFSL FQVVLEMRKQ RPAAVQTEEQ YRFLYHTVAQ LFSRTLQDTS 300
    PHYQNLKENC APICKEAFSL RTSSALPATS RPPGGVLRSI SVPAPPTLPM 350
    ADTYAVVQKR GASAGTGPGP RAPTSTDTPI YSQVAPRAQR PVAHTEDAQG 400
    TTALRRVPAD QNSSGPDAYE EVTDGAQTGG LGFNLRIGRP KGPRDPPAEW 450
    TRV 453
    Length:453
    Mass (Da):50,202
    Last modified:November 1, 1996 - v1
    Checksum:i88AD7E73CE8136B0
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti11 – 111F → L in AAC52991. (PubMed:8977243)Curated
    Sequence conflicti57 – 571T → M in AAH08512. (PubMed:15489334)Curated
    Sequence conflicti95 – 951I → T in AAH08512. (PubMed:15489334)Curated
    Sequence conflicti184 – 1841F → S in AAH08512. (PubMed:15489334)Curated
    Sequence conflicti362 – 3687ASAGTGP → LRRHRA in AAC52991. (PubMed:8977243)Curated
    Sequence conflicti365 – 3651G → V in AAH08512. (PubMed:15489334)Curated
    Sequence conflicti374 – 3741T → N in AAH08512. (PubMed:15489334)Curated
    Sequence conflicti401 – 4011T → I in AAH08512. (PubMed:15489334)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U49853 mRNA. Translation: AAB18623.1.
    U35124 mRNA. Translation: AAB82736.1.
    U52523 mRNA. Translation: AAC52991.1.
    AK144353 mRNA. Translation: BAE25845.1.
    BC008512 mRNA. Translation: AAH08512.1.
    CCDSiCCDS14867.1.
    RefSeqiNP_035336.2. NM_011206.2.
    UniGeneiMm.361.

    Genome annotation databases

    EnsembliENSMUST00000027302; ENSMUSP00000027302; ENSMUSG00000026126.
    GeneIDi19253.
    KEGGimmu:19253.
    UCSCiuc007aos.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U49853 mRNA. Translation: AAB18623.1 .
    U35124 mRNA. Translation: AAB82736.1 .
    U52523 mRNA. Translation: AAC52991.1 .
    AK144353 mRNA. Translation: BAE25845.1 .
    BC008512 mRNA. Translation: AAH08512.1 .
    CCDSi CCDS14867.1.
    RefSeqi NP_035336.2. NM_011206.2.
    UniGenei Mm.361.

    3D structure databases

    ProteinModelPortali Q61152.
    SMRi Q61152. Positions 25-292.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    IntActi Q61152. 2 interactions.
    MINTi MINT-157346.
    STRINGi 10090.ENSMUSP00000027302.

    PTM databases

    PhosphoSitei Q61152.

    Proteomic databases

    PaxDbi Q61152.
    PRIDEi Q61152.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000027302 ; ENSMUSP00000027302 ; ENSMUSG00000026126 .
    GeneIDi 19253.
    KEGGi mmu:19253.
    UCSCi uc007aos.1. mouse.

    Organism-specific databases

    CTDi 26469.
    MGIi MGI:108410. Ptpn18.

    Phylogenomic databases

    eggNOGi COG5599.
    GeneTreei ENSGT00750000117233.
    HOGENOMi HOG000115776.
    HOVERGENi HBG053419.
    InParanoidi Q61152.
    KOi K18024.
    OMAi NCAPLYD.
    OrthoDBi EOG744T8Z.
    PhylomeDBi Q61152.
    TreeFami TF351977.

    Miscellaneous databases

    NextBioi 296096.
    PMAP-CutDB Q61152.
    PROi Q61152.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q61152.
    Genevestigatori Q61152.

    Family and domain databases

    Gene3Di 3.90.190.10. 1 hit.
    InterProi IPR029021. Prot-tyrosine_phosphatase-like.
    IPR000387. Tyr/Dual-sp_Pase.
    IPR016130. Tyr_Pase_AS.
    IPR000242. Tyr_Pase_rcpt/non-rcpt.
    [Graphical view ]
    Pfami PF00102. Y_phosphatase. 1 hit.
    [Graphical view ]
    PRINTSi PR00700. PRTYPHPHTASE.
    SMARTi SM00194. PTPc. 1 hit.
    [Graphical view ]
    SUPFAMi SSF52799. SSF52799. 1 hit.
    PROSITEi PS00383. TYR_PHOSPHATASE_1. 1 hit.
    PS50056. TYR_PHOSPHATASE_2. 1 hit.
    PS50055. TYR_PHOSPHATASE_PTP. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "A novel protein tyrosine phosphatase expressed in lin(lo)CD34(hi)Sca(hi) hematopoietic progenitor cells."
      Cheng J., Daimaru L., Fennie C., Lasky L.A.
      Blood 88:1156-1167(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
      Tissue: Embryo.
    2. "Cloning and characterization of PTP-K1, a novel nonreceptor protein tyrosine phosphatase highly expressed in bone marrow."
      Huang K., Sommers C.L., Grinberg A., Kozak C.A., Love P.E.
      Oncogene 13:1567-1573(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
      Tissue: Kidney.
    3. "Cloning and characterization of fetal liver phosphatase 1, a nuclear protein tyrosine phosphatase isolated from hematopoietic stem cells."
      Dosil M., Leibman N., Lemischka I.R.
      Blood 88:4510-4525(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
      Strain: C57BL/6.
      Tissue: Fetal liver.
    4. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6J.
      Tissue: Intestinal mucosa.
    5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: Czech II.
      Tissue: Mammary tumor.
    6. "PSTPIP: a tyrosine phosphorylated cleavage furrow-associated protein that is a substrate for a PEST tyrosine phosphatase."
      Spencer S., Dowbenko D., Cheng J., Li W., Brush J., Utzig S., Simanis V., Lasky L.A.
      J. Cell Biol. 138:845-860(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH PSTPIP1.
    7. "Quantitative time-resolved phosphoproteomic analysis of mast cell signaling."
      Cao L., Yu K., Banh C., Nguyen V., Ritz A., Raphael B.J., Kawakami Y., Kawakami T., Salomon A.R.
      J. Immunol. 179:5864-5876(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-381 AND TYR-419, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Mast cell.
    8. "The phagosomal proteome in interferon-gamma-activated macrophages."
      Trost M., English L., Lemieux S., Courcelles M., Desjardins M., Thibault P.
      Immunity 30:143-154(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-381, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiPTN18_MOUSE
    AccessioniPrimary (citable) accession number: Q61152
    Secondary accession number(s): Q4JFH4, Q62404, Q922E3
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 24, 2006
    Last sequence update: November 1, 1996
    Last modified: October 1, 2014
    This is version 109 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3