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Q61152 (PTN18_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 108. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Interactions·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Tyrosine-protein phosphatase non-receptor type 18

EC=3.1.3.48
Alternative name(s):
Fetal liver phosphatase 1
Short name=FLP-1
PTP-K1
Gene names
Name:Ptpn18
Synonyms:Flp1, Ptpk1
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length453 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

May be involved in growth and differentiation of hematopoietic cells.

Catalytic activity

Protein tyrosine phosphate + H2O = protein tyrosine + phosphate.

Subunit structure

Interacts with PSTPIP1. Ref.6

Subcellular location

Nucleus. Cytoplasm Ref.3.

Tissue specificity

Highest expression in bone marrow. Also expressed in kidney, lung, ovary, spleen, thymus and lymph node. Ref.1 Ref.2 Ref.3

Developmental stage

Expressed in the embryo from day 15.5.

Sequence similarities

Belongs to the protein-tyrosine phosphatase family. Non-receptor class 4 subfamily.

Contains 1 tyrosine-protein phosphatase domain.

Binary interactions

With

Entry

#Exp.

IntAct

Notes

Pstpip1P978143EBI-7074223,EBI-7484574
Pstpip2Q99M157EBI-7074223,EBI-8653964

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 453453Tyrosine-protein phosphatase non-receptor type 18
PRO_0000094774

Regions

Domain26 – 291266Tyrosine-protein phosphatase
Region229 – 2357Substrate binding By similarity

Sites

Active site2291Phosphocysteine intermediate By similarity
Binding site1971Substrate By similarity
Binding site2761Substrate By similarity

Amino acid modifications

Modified residue3811Phosphotyrosine Ref.7 Ref.8
Modified residue4191Phosphotyrosine Ref.7

Experimental info

Sequence conflict111F → L in AAC52991. Ref.3
Sequence conflict571T → M in AAH08512. Ref.5
Sequence conflict951I → T in AAH08512. Ref.5
Sequence conflict1841F → S in AAH08512. Ref.5
Sequence conflict362 – 3687ASAGTGP → LRRHRA in AAC52991. Ref.3
Sequence conflict3651G → V in AAH08512. Ref.5
Sequence conflict3741T → N in AAH08512. Ref.5
Sequence conflict4011T → I in AAH08512. Ref.5

Sequences

Sequence LengthMass (Da)Tools
Q61152 [UniParc].

Last modified November 1, 1996. Version 1.
Checksum: 88AD7E73CE8136B0

FASTA45350,202
        10         20         30         40         50         60 
MSRHTDLVRS FLEQLEARDY REGAILAREF SDIKARSVAW KSEGVCSTKA GSRLGNTNKN 

        70         80         90        100        110        120 
RYKDVVAYDE TRVILSLLQE EGHGDYINAN FIRGIDGSQA YIATQGPLPH TLLDFWRLVW 

       130        140        150        160        170        180 
EFGVKVILMA CQETENGRRK CERYWAREQE PLKAGPFCIT LTKETTLNAD ITLRTLQVTF 

       190        200        210        220        230        240 
QKEFRSVHQL QYMSWPDHGV PSSSDHILTM VEEARCLQGL GPGPLCVHCS AGCGRTGVLC 

       250        260        270        280        290        300 
AVDYVRQLLL TQTIPPNFSL FQVVLEMRKQ RPAAVQTEEQ YRFLYHTVAQ LFSRTLQDTS 

       310        320        330        340        350        360 
PHYQNLKENC APICKEAFSL RTSSALPATS RPPGGVLRSI SVPAPPTLPM ADTYAVVQKR 

       370        380        390        400        410        420 
GASAGTGPGP RAPTSTDTPI YSQVAPRAQR PVAHTEDAQG TTALRRVPAD QNSSGPDAYE 

       430        440        450 
EVTDGAQTGG LGFNLRIGRP KGPRDPPAEW TRV 

« Hide

References

« Hide 'large scale' references
[1]"A novel protein tyrosine phosphatase expressed in lin(lo)CD34(hi)Sca(hi) hematopoietic progenitor cells."
Cheng J., Daimaru L., Fennie C., Lasky L.A.
Blood 88:1156-1167(1996) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
Tissue: Embryo.
[2]"Cloning and characterization of PTP-K1, a novel nonreceptor protein tyrosine phosphatase highly expressed in bone marrow."
Huang K., Sommers C.L., Grinberg A., Kozak C.A., Love P.E.
Oncogene 13:1567-1573(1996) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
Tissue: Kidney.
[3]"Cloning and characterization of fetal liver phosphatase 1, a nuclear protein tyrosine phosphatase isolated from hematopoietic stem cells."
Dosil M., Leibman N., Lemischka I.R.
Blood 88:4510-4525(1996) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
Strain: C57BL/6.
Tissue: Fetal liver.
[4]"The transcriptional landscape of the mammalian genome."
Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. expand/collapse author list , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: C57BL/6J.
Tissue: Intestinal mucosa.
[5]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: Czech II.
Tissue: Mammary tumor.
[6]"PSTPIP: a tyrosine phosphorylated cleavage furrow-associated protein that is a substrate for a PEST tyrosine phosphatase."
Spencer S., Dowbenko D., Cheng J., Li W., Brush J., Utzig S., Simanis V., Lasky L.A.
J. Cell Biol. 138:845-860(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: INTERACTION WITH PSTPIP1.
[7]"Quantitative time-resolved phosphoproteomic analysis of mast cell signaling."
Cao L., Yu K., Banh C., Nguyen V., Ritz A., Raphael B.J., Kawakami Y., Kawakami T., Salomon A.R.
J. Immunol. 179:5864-5876(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-381 AND TYR-419, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
Tissue: Mast cell.
[8]"The phagosomal proteome in interferon-gamma-activated macrophages."
Trost M., English L., Lemieux S., Courcelles M., Desjardins M., Thibault P.
Immunity 30:143-154(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-381, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
U49853 mRNA. Translation: AAB18623.1.
U35124 mRNA. Translation: AAB82736.1.
U52523 mRNA. Translation: AAC52991.1.
AK144353 mRNA. Translation: BAE25845.1.
BC008512 mRNA. Translation: AAH08512.1.
CCDSCCDS14867.1.
RefSeqNP_035336.2. NM_011206.2.
UniGeneMm.361.

3D structure databases

ProteinModelPortalQ61152.
SMRQ61152. Positions 25-292.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

IntActQ61152. 2 interactions.
MINTMINT-157346.
STRING10090.ENSMUSP00000027302.

PTM databases

PhosphoSiteQ61152.

Proteomic databases

PaxDbQ61152.
PRIDEQ61152.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000027302; ENSMUSP00000027302; ENSMUSG00000026126.
GeneID19253.
KEGGmmu:19253.
UCSCuc007aos.1. mouse.

Organism-specific databases

CTD26469.
MGIMGI:108410. Ptpn18.

Phylogenomic databases

eggNOGCOG5599.
GeneTreeENSGT00750000117233.
HOGENOMHOG000115776.
HOVERGENHBG053419.
InParanoidQ61152.
KOK18024.
OMANCAPLYD.
OrthoDBEOG744T8Z.
PhylomeDBQ61152.
TreeFamTF351977.

Gene expression databases

BgeeQ61152.
GenevestigatorQ61152.

Family and domain databases

Gene3D3.90.190.10. 1 hit.
InterProIPR029021. Prot-tyrosine_phosphatase-like.
IPR000387. Tyr/Dual-sp_Pase.
IPR016130. Tyr_Pase_AS.
IPR000242. Tyr_Pase_rcpt/non-rcpt.
[Graphical view]
PfamPF00102. Y_phosphatase. 1 hit.
[Graphical view]
PRINTSPR00700. PRTYPHPHTASE.
SMARTSM00194. PTPc. 1 hit.
[Graphical view]
SUPFAMSSF52799. SSF52799. 1 hit.
PROSITEPS00383. TYR_PHOSPHATASE_1. 1 hit.
PS50056. TYR_PHOSPHATASE_2. 1 hit.
PS50055. TYR_PHOSPHATASE_PTP. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio296096.
PMAP-CutDBQ61152.
PROQ61152.
SOURCESearch...

Entry information

Entry namePTN18_MOUSE
AccessionPrimary (citable) accession number: Q61152
Secondary accession number(s): Q4JFH4, Q62404, Q922E3
Entry history
Integrated into UniProtKB/Swiss-Prot: January 24, 2006
Last sequence update: November 1, 1996
Last modified: July 9, 2014
This is version 108 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot