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Protein

Tyrosine-protein phosphatase non-receptor type 18

Gene

Ptpn18

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

May be involved in growth and differentiation of hematopoietic cells.

Catalytic activityi

Protein tyrosine phosphate + H2O = protein tyrosine + phosphate.PROSITE-ProRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei197SubstrateBy similarity1
Active sitei229Phosphocysteine intermediatePROSITE-ProRule annotation1
Binding sitei276SubstrateBy similarity1

GO - Molecular functioni

  • non-membrane spanning protein tyrosine phosphatase activity Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protein phosphatase

Enzyme and pathway databases

ReactomeiR-MMU-8863795. Downregulation of ERBB2 signaling.

Names & Taxonomyi

Protein namesi
Recommended name:
Tyrosine-protein phosphatase non-receptor type 18 (EC:3.1.3.48)
Alternative name(s):
Fetal liver phosphatase 1
Short name:
FLP-1
PTP-K1
Gene namesi
Name:Ptpn18
Synonyms:Flp1, Ptpk1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 1

Organism-specific databases

MGIiMGI:108410. Ptpn18.

Subcellular locationi

  • Nucleus 1 Publication
  • Cytoplasm 1 Publication

GO - Cellular componenti

  • cytoplasm Source: MGI
  • nucleus Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000947741 – 453Tyrosine-protein phosphatase non-receptor type 18Add BLAST453

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei381PhosphotyrosineCombined sources1
Modified residuei419PhosphotyrosineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ61152.
MaxQBiQ61152.
PaxDbiQ61152.
PeptideAtlasiQ61152.
PRIDEiQ61152.

PTM databases

iPTMnetiQ61152.
PhosphoSitePlusiQ61152.

Miscellaneous databases

PMAP-CutDBQ61152.

Expressioni

Tissue specificityi

Highest expression in bone marrow. Also expressed in kidney, lung, ovary, spleen, thymus and lymph node.3 Publications

Developmental stagei

Expressed in the embryo from day 15.5.

Gene expression databases

BgeeiENSMUSG00000026126.
ExpressionAtlasiQ61152. baseline and differential.
GenevisibleiQ61152. MM.

Interactioni

Subunit structurei

Interacts with PSTPIP1.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
Pstpip1P978143EBI-7074223,EBI-7484574
Pstpip2Q99M157EBI-7074223,EBI-8653964

Protein-protein interaction databases

IntActiQ61152. 2 interactors.
MINTiMINT-157346.
STRINGi10090.ENSMUSP00000027302.

Structurei

3D structure databases

ProteinModelPortaliQ61152.
SMRiQ61152.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini26 – 291Tyrosine-protein phosphatasePROSITE-ProRule annotationAdd BLAST266

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni229 – 235Substrate bindingBy similarity7

Sequence similaritiesi

Contains 1 tyrosine-protein phosphatase domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG0789. Eukaryota.
COG5599. LUCA.
GeneTreeiENSGT00770000120452.
HOGENOMiHOG000115776.
HOVERGENiHBG053419.
InParanoidiQ61152.
KOiK18024.
OMAiNCAPLYD.
OrthoDBiEOG091G0B5O.
PhylomeDBiQ61152.
TreeFamiTF351977.

Family and domain databases

Gene3Di3.90.190.10. 1 hit.
InterProiIPR029021. Prot-tyrosine_phosphatase-like.
IPR000242. PTPase_domain.
IPR016130. Tyr_Pase_AS.
IPR003595. Tyr_Pase_cat.
IPR000387. TYR_PHOSPHATASE_dom.
[Graphical view]
PfamiPF00102. Y_phosphatase. 1 hit.
[Graphical view]
PRINTSiPR00700. PRTYPHPHTASE.
SMARTiSM00194. PTPc. 1 hit.
SM00404. PTPc_motif. 1 hit.
[Graphical view]
SUPFAMiSSF52799. SSF52799. 1 hit.
PROSITEiPS00383. TYR_PHOSPHATASE_1. 1 hit.
PS50056. TYR_PHOSPHATASE_2. 1 hit.
PS50055. TYR_PHOSPHATASE_PTP. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q61152-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSRHTDLVRS FLEQLEARDY REGAILAREF SDIKARSVAW KSEGVCSTKA
60 70 80 90 100
GSRLGNTNKN RYKDVVAYDE TRVILSLLQE EGHGDYINAN FIRGIDGSQA
110 120 130 140 150
YIATQGPLPH TLLDFWRLVW EFGVKVILMA CQETENGRRK CERYWAREQE
160 170 180 190 200
PLKAGPFCIT LTKETTLNAD ITLRTLQVTF QKEFRSVHQL QYMSWPDHGV
210 220 230 240 250
PSSSDHILTM VEEARCLQGL GPGPLCVHCS AGCGRTGVLC AVDYVRQLLL
260 270 280 290 300
TQTIPPNFSL FQVVLEMRKQ RPAAVQTEEQ YRFLYHTVAQ LFSRTLQDTS
310 320 330 340 350
PHYQNLKENC APICKEAFSL RTSSALPATS RPPGGVLRSI SVPAPPTLPM
360 370 380 390 400
ADTYAVVQKR GASAGTGPGP RAPTSTDTPI YSQVAPRAQR PVAHTEDAQG
410 420 430 440 450
TTALRRVPAD QNSSGPDAYE EVTDGAQTGG LGFNLRIGRP KGPRDPPAEW

TRV
Length:453
Mass (Da):50,202
Last modified:November 1, 1996 - v1
Checksum:i88AD7E73CE8136B0
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti11F → L in AAC52991 (PubMed:8977243).Curated1
Sequence conflicti57T → M in AAH08512 (PubMed:15489334).Curated1
Sequence conflicti95I → T in AAH08512 (PubMed:15489334).Curated1
Sequence conflicti184F → S in AAH08512 (PubMed:15489334).Curated1
Sequence conflicti362 – 368ASAGTGP → LRRHRA in AAC52991 (PubMed:8977243).Curated7
Sequence conflicti365G → V in AAH08512 (PubMed:15489334).Curated1
Sequence conflicti374T → N in AAH08512 (PubMed:15489334).Curated1
Sequence conflicti401T → I in AAH08512 (PubMed:15489334).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U49853 mRNA. Translation: AAB18623.1.
U35124 mRNA. Translation: AAB82736.1.
U52523 mRNA. Translation: AAC52991.1.
AK144353 mRNA. Translation: BAE25845.1.
BC008512 mRNA. Translation: AAH08512.1.
CCDSiCCDS14867.1.
RefSeqiNP_035336.2. NM_011206.2.
UniGeneiMm.361.

Genome annotation databases

EnsembliENSMUST00000027302; ENSMUSP00000027302; ENSMUSG00000026126.
GeneIDi19253.
KEGGimmu:19253.
UCSCiuc007aos.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U49853 mRNA. Translation: AAB18623.1.
U35124 mRNA. Translation: AAB82736.1.
U52523 mRNA. Translation: AAC52991.1.
AK144353 mRNA. Translation: BAE25845.1.
BC008512 mRNA. Translation: AAH08512.1.
CCDSiCCDS14867.1.
RefSeqiNP_035336.2. NM_011206.2.
UniGeneiMm.361.

3D structure databases

ProteinModelPortaliQ61152.
SMRiQ61152.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ61152. 2 interactors.
MINTiMINT-157346.
STRINGi10090.ENSMUSP00000027302.

PTM databases

iPTMnetiQ61152.
PhosphoSitePlusiQ61152.

Proteomic databases

EPDiQ61152.
MaxQBiQ61152.
PaxDbiQ61152.
PeptideAtlasiQ61152.
PRIDEiQ61152.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000027302; ENSMUSP00000027302; ENSMUSG00000026126.
GeneIDi19253.
KEGGimmu:19253.
UCSCiuc007aos.1. mouse.

Organism-specific databases

CTDi26469.
MGIiMGI:108410. Ptpn18.

Phylogenomic databases

eggNOGiKOG0789. Eukaryota.
COG5599. LUCA.
GeneTreeiENSGT00770000120452.
HOGENOMiHOG000115776.
HOVERGENiHBG053419.
InParanoidiQ61152.
KOiK18024.
OMAiNCAPLYD.
OrthoDBiEOG091G0B5O.
PhylomeDBiQ61152.
TreeFamiTF351977.

Enzyme and pathway databases

ReactomeiR-MMU-8863795. Downregulation of ERBB2 signaling.

Miscellaneous databases

PMAP-CutDBQ61152.
PROiQ61152.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000026126.
ExpressionAtlasiQ61152. baseline and differential.
GenevisibleiQ61152. MM.

Family and domain databases

Gene3Di3.90.190.10. 1 hit.
InterProiIPR029021. Prot-tyrosine_phosphatase-like.
IPR000242. PTPase_domain.
IPR016130. Tyr_Pase_AS.
IPR003595. Tyr_Pase_cat.
IPR000387. TYR_PHOSPHATASE_dom.
[Graphical view]
PfamiPF00102. Y_phosphatase. 1 hit.
[Graphical view]
PRINTSiPR00700. PRTYPHPHTASE.
SMARTiSM00194. PTPc. 1 hit.
SM00404. PTPc_motif. 1 hit.
[Graphical view]
SUPFAMiSSF52799. SSF52799. 1 hit.
PROSITEiPS00383. TYR_PHOSPHATASE_1. 1 hit.
PS50056. TYR_PHOSPHATASE_2. 1 hit.
PS50055. TYR_PHOSPHATASE_PTP. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiPTN18_MOUSE
AccessioniPrimary (citable) accession number: Q61152
Secondary accession number(s): Q4JFH4, Q62404, Q922E3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 24, 2006
Last sequence update: November 1, 1996
Last modified: November 30, 2016
This is version 125 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.