Tyrosine-protein phosphatase non-receptor type 18

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Q61152 (PTN18_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified April 3, 2013. Version 98. History...

Clusters with 100%, 90%, 50% identity |

Documents (2) |

Third-party data

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Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents Customize order

Names and origin

Protein names

Recommended name:
Tyrosine-protein phosphatase non-receptor type 18
EC=3.1.3.48

Alternative name(s):
Fetal liver phosphatase 1
Short name=FLP-1
PTP-K1

Gene names

Name:	Ptpn18
Synonyms:	Flp1, Ptpk1

Organism

Mus musculus (Mouse) [Reference proteome]

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length	453 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	May be involved in growth and differentiation of hematopoietic cells.
Catalytic activity	Protein tyrosine phosphate + H₂O = protein tyrosine + phosphate.
Subunit structure	Interacts with PSTPIP1. Ref.6
Subcellular location	Nucleus. Cytoplasm Ref.3.
Tissue specificity	Highest expression in bone marrow. Also expressed in kidney, lung, ovary, spleen, thymus and lymph node. Ref.1 Ref.2 Ref.3
Developmental stage	Expressed in the embryo from day 15.5.
Sequence similarities	Belongs to the protein-tyrosine phosphatase family. Non-receptor class 4 subfamily. Contains 1 tyrosine-protein phosphatase domain.

Ontologies

Keywords
Cellular component	Cytoplasm Nucleus
Molecular function	Hydrolase Protein phosphatase
PTM	Phosphoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Cellular_component	cytoplasm Inferred from direct assay Ref.2. Source: MGI nucleus Inferred from direct assay Ref.2. Source: MGI
Molecular_function	non-membrane spanning protein tyrosine phosphatase activity Inferred from direct assay Ref.2. Source: MGI
Complete GO annotation...

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – 453

453

Tyrosine-protein phosphatase non-receptor type 18

PRO_0000094774

Regions

Domain

26 – 291

266

Tyrosine-protein phosphatase

Region

229 – 235

Substrate binding By similarity

Sites

Active site

229

Phosphocysteine intermediate By similarity

Binding site

197

Substrate By similarity

Binding site

276

Substrate By similarity

Amino acid modifications

Modified residue

381

Phosphotyrosine Ref.7

Modified residue

419

Phosphotyrosine Ref.7

Experimental info

Sequence conflict

F → L in AAC52991. Ref.3

Sequence conflict

T → M in AAH08512. Ref.5

Sequence conflict

I → T in AAH08512. Ref.5

Sequence conflict

184

F → S in AAH08512. Ref.5

Sequence conflict

362 – 368

ASAGTGP → LRRHRA in AAC52991. Ref.3

Sequence conflict

365

G → V in AAH08512. Ref.5

Sequence conflict

374

T → N in AAH08512. Ref.5

Sequence conflict

401

T → I in AAH08512. Ref.5

Sequences

Sequence

Length

Mass (Da)

Tools

Q61152 [UniParc].

Last modified November 1, 1996. Version 1.
Checksum: 88AD7E73CE8136B0
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FASTA

453

50,202

        10         20         30         40         50         60 
MSRHTDLVRS FLEQLEARDY REGAILAREF SDIKARSVAW KSEGVCSTKA GSRLGNTNKN 

        70         80         90        100        110        120 
RYKDVVAYDE TRVILSLLQE EGHGDYINAN FIRGIDGSQA YIATQGPLPH TLLDFWRLVW 

       130        140        150        160        170        180 
EFGVKVILMA CQETENGRRK CERYWAREQE PLKAGPFCIT LTKETTLNAD ITLRTLQVTF 

       190        200        210        220        230        240 
QKEFRSVHQL QYMSWPDHGV PSSSDHILTM VEEARCLQGL GPGPLCVHCS AGCGRTGVLC 

       250        260        270        280        290        300 
AVDYVRQLLL TQTIPPNFSL FQVVLEMRKQ RPAAVQTEEQ YRFLYHTVAQ LFSRTLQDTS 

       310        320        330        340        350        360 
PHYQNLKENC APICKEAFSL RTSSALPATS RPPGGVLRSI SVPAPPTLPM ADTYAVVQKR 

       370        380        390        400        410        420 
GASAGTGPGP RAPTSTDTPI YSQVAPRAQR PVAHTEDAQG TTALRRVPAD QNSSGPDAYE 

       430        440        450 
EVTDGAQTGG LGFNLRIGRP KGPRDPPAEW TRV

« Hide

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"A novel protein tyrosine phosphatase expressed in lin(lo)CD34(hi)Sca(hi) hematopoietic progenitor cells." Cheng J., Daimaru L., Fennie C., Lasky L.A. Blood 88:1156-1167(1996) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY. Tissue: Embryo.
[2]	"Cloning and characterization of PTP-K1, a novel nonreceptor protein tyrosine phosphatase highly expressed in bone marrow." Huang K., Sommers C.L., Grinberg A., Kozak C.A., Love P.E. Oncogene 13:1567-1573(1996) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY. Tissue: Kidney.
[3]	"Cloning and characterization of fetal liver phosphatase 1, a nuclear protein tyrosine phosphatase isolated from hematopoietic stem cells." Dosil M., Leibman N., Lemischka I.R. Blood 88:4510-4525(1996) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], SUBCELLULAR LOCATION, TISSUE SPECIFICITY. Strain: C57BL/6. Tissue: Fetal liver.
[4]	"The transcriptional landscape of the mammalian genome." Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. Hayashizaki Y. Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: C57BL/6J. Tissue: Intestinal mucosa.
[5]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: Czech II. Tissue: Mammary tumor.
[6]	"PSTPIP: a tyrosine phosphorylated cleavage furrow-associated protein that is a substrate for a PEST tyrosine phosphatase." Spencer S., Dowbenko D., Cheng J., Li W., Brush J., Utzig S., Simanis V., Lasky L.A. J. Cell Biol. 138:845-860(1997) [PubMed] [Europe PMC] [Abstract] Cited for: INTERACTION WITH PSTPIP1.
[7]	"Quantitative time-resolved phosphoproteomic analysis of mast cell signaling." Cao L., Yu K., Banh C., Nguyen V., Ritz A., Raphael B.J., Kawakami Y., Kawakami T., Salomon A.R. J. Immunol. 179:5864-5876(2007) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-381 AND TYR-419, MASS SPECTROMETRY. Tissue: Mast cell.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	U49853 mRNA. Translation: AAB18623.1. U35124 mRNA. Translation: AAB82736.1. U52523 mRNA. Translation: AAC52991.1. AK144353 mRNA. Translation: BAE25845.1. BC008512 mRNA. Translation: AAH08512.1.
IPI	IPI00117861.
RefSeq	NP_035336.2. NM_011206.2.
UniGene	Mm.361.
3D structure databases
ProteinModelPortal	Q61152.
SMR	Q61152. Positions 10-292.
ModBase	Search...
Protein-protein interaction databases
MINT	MINT-157346.
STRING	10090.ENSMUSP00000027302.
PTM databases
PhosphoSite	Q61152.
Proteomic databases
PaxDb	Q61152.
PRIDE	Q61152.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSMUST00000027302; ENSMUSP00000027302; ENSMUSG00000026126.
GeneID	19253.
KEGG	mmu:19253.
UCSC	uc007aos.1. mouse.
Organism-specific databases
CTD	26469.
MGI	MGI:108410. Ptpn18.
Phylogenomic databases
eggNOG	COG5599.
GeneTree	ENSGT00700000104095.
HOGENOM	HOG000115776.
HOVERGEN	HBG053419.
InParanoid	Q61152.
KO	K01104.
OMA	GLGFNLR.
OrthoDB	EOG4X0MSD.
Gene expression databases
Bgee	Q61152.
Genevestigator	Q61152.
GermOnline	ENSMUSG00000026126. Mus musculus.
Family and domain databases
InterPro	IPR000387. Tyr/Dual-sp_Pase. IPR016130. Tyr_Pase_AS. IPR000242. Tyr_Pase_rcpt/non-rcpt. [Graphical view]
Pfam	PF00102. Y_phosphatase. 1 hit. [Graphical view]
PRINTS	PR00700. PRTYPHPHTASE.
SMART	SM00194. PTPc. 1 hit. [Graphical view]
PROSITE	PS00383. TYR_PHOSPHATASE_1. 1 hit. PS50056. TYR_PHOSPHATASE_2. 1 hit. PS50055. TYR_PHOSPHATASE_PTP. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	296096.
PMAP-CutDB	Q61152.
SOURCE	Search...

Entry information

Entry name

PTN18_MOUSE

Accession

Primary (citable) accession number: Q61152
Secondary accession number(s): Q4JFH4, Q62404, Q922E3

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 24, 2006
Last sequence update:	November 1, 1996
Last modified:	April 3, 2013
This is version 98 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Relevant documents

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

SIMILARITY comments

Index of protein domains and families

Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents

Preferred order of sections

Names and origin

Protein attributes

General annotation (Comments)

Ontologies

Sequence annotation (Features)

Molecule processing

Regions

Sites

Amino acid modifications

Experimental info

Sequences

References

Cross-references

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Gene expression databases

Family and domain databases

Other

Entry information

Relevant documents