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Q61151

- 2A5E_MOUSE

UniProt

Q61151 - 2A5E_MOUSE

Protein

Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit epsilon isoform

Gene

Ppp2r5e

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 101 (01 Oct 2014)
      Sequence version 3 (19 Jul 2005)
      Previous versions | rss
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    Functioni

    The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. Interacts with cyclin G in vitro.

    GO - Molecular functioni

    1. protein phosphatase type 2A regulator activity Source: InterPro

    GO - Biological processi

    1. signal transduction Source: InterPro

    Enzyme and pathway databases

    ReactomeiREACT_198961. Resolution of Sister Chromatid Cohesion.
    REACT_203336. Degradation of beta-catenin by the destruction complex.
    REACT_207679. Separation of Sister Chromatids.
    REACT_216784. disassembly of the destruction complex and recruitment of AXIN to the membrane.
    REACT_218396. Beta-catenin phosphorylation cascade.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit epsilon isoform
    Alternative name(s):
    PP2A B subunit isoform B'-epsilon
    PP2A B subunit isoform B56-epsilon
    PP2A B subunit isoform PR61-epsilon
    PP2A B subunit isoform R5-epsilon
    Gene namesi
    Name:Ppp2r5e
    Synonyms:Kiaa4006
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 12

    Organism-specific databases

    MGIiMGI:1349473. Ppp2r5e.

    Subcellular locationi

    Cytoplasm By similarity

    GO - Cellular componenti

    1. cytoplasm Source: MGI
    2. intracellular membrane-bounded organelle Source: Ensembl
    3. protein phosphatase type 2A complex Source: InterPro

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Initiator methioninei1 – 11RemovedBy similarity
    Chaini2 – 467466Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit epsilon isoformPRO_0000071455Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei2 – 21N-acetylserineBy similarity
    Modified residuei30 – 301PhosphoserineBy similarity
    Modified residuei32 – 321PhosphoserineBy similarity
    Modified residuei34 – 341PhosphoserineBy similarity

    Keywords - PTMi

    Acetylation, Phosphoprotein

    Proteomic databases

    MaxQBiQ61151.
    PaxDbiQ61151.
    PRIDEiQ61151.

    PTM databases

    PhosphoSiteiQ61151.

    Expressioni

    Gene expression databases

    BgeeiQ61151.
    GenevestigatoriQ61151.

    Interactioni

    Subunit structurei

    PP2A consists of a common heterodimeric core enzyme, composed of a 36 kDa catalytic subunit (subunit C) and a 65 kDa constant regulatory subunit (PR65 or subunit A), that associates with a variety of regulatory subunits. Proteins that associate with the core dimer include three families of regulatory subunits B (the R2/B/PR55/B55, R3/B''/PR72/PR130/PR59 and R5/B'/B56 families), the 48 kDa variable regulatory subunit, viral proteins, and cell signaling molecules. Interacts with SGOL1. Found in a complex with at least ARL2, PPP2CB; PPP2R1A, PPP2R2A, PPP2R5E and TBCD By similarity.By similarity

    Protein-protein interaction databases

    IntActiQ61151. 3 interactions.
    MINTiMINT-4114181.

    Structurei

    3D structure databases

    ProteinModelPortaliQ61151.
    SMRiQ61151. Positions 51-423.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Phylogenomic databases

    eggNOGiNOG264925.
    GeneTreeiENSGT00550000074525.
    HOGENOMiHOG000067326.
    HOVERGENiHBG000009.
    InParanoidiQ61151.
    KOiK11584.
    OMAiTEQAYPE.
    OrthoDBiEOG7C2R2S.
    PhylomeDBiQ61151.
    TreeFamiTF105556.

    Family and domain databases

    InterProiIPR016024. ARM-type_fold.
    IPR002554. PP2A_B56.
    [Graphical view]
    PANTHERiPTHR10257. PTHR10257. 1 hit.
    PfamiPF01603. B56. 1 hit.
    [Graphical view]
    PIRSFiPIRSF028043. PP2A_B56. 1 hit.
    SUPFAMiSSF48371. SSF48371. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q61151-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSSAPTTPPS VDKVDGFSRK SVRKARQKRS QSSSQFRSQG KPIELTPLPL    50
    LKDVPTSEQP ELFLKKLQQC CVIFDFMDTL SDLKMKEYKR STLNELVDYI 100
    TISRGCLTEQ TYPEVVRMVS CNIFRTLPPS DSNEFDPEED EPTLEASWPH 150
    LQLVYEFFIR FLESQEFQPS IAKKYIDQKF VLQLLELFDS EDPRERDYLK 200
    TVLHRIYGKF LGLRAFIRKQ INNIFLRFVY ETEHFNGVAE LLEILGSIIN 250
    GFALPLKAEH KQFLVKVLIP LHTVRSLSLF HAQLAYCIVQ FLEKDPSLTE 300
    PVIRGLMKFW PKTCSQKEVM FLGELEEILD VIEPSQFVKI QEPLFKQIAK 350
    CVSSPHFQVA ERALYYWNNE YIMSLIEENS NVILPIMFSS LYRISKEHWN 400
    PAIVALVYNV LKAFMEMNST MFDELTATYK SDRQREKKKE KEREELWKKL 450
    EDLELKRGLR RDGIIPT 467
    Length:467
    Mass (Da):54,713
    Last modified:July 19, 2005 - v3
    Checksum:i77DA129F9A4EC6AC
    GO

    Sequence cautioni

    The sequence AAB37234.1 differs from that shown. Reason: Frameshift at positions 162, 180 and 185.
    The sequence BAD90335.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti74 – 741F → C in AAB37234. (PubMed:8887688)Curated
    Sequence conflicti162 – 1621L → W in AAB37234. (PubMed:8887688)Curated
    Sequence conflicti388 – 3881F → S in AAB37234. (PubMed:8887688)Curated
    Sequence conflicti409 – 4091N → T in AAB37234. (PubMed:8887688)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK088366 mRNA. Translation: BAC40306.1.
    AK132432 mRNA. Translation: BAE21166.1.
    BC085149 mRNA. Translation: AAH85149.1.
    AK220163 mRNA. Translation: BAD90335.1. Different initiation.
    U49728 mRNA. Translation: AAB37234.1. Frameshift.
    CCDSiCCDS25983.1.
    RefSeqiNP_036154.1. NM_012024.2.
    XP_006515988.1. XM_006515925.1.
    UniGeneiMm.259626.
    Mm.440646.

    Genome annotation databases

    EnsembliENSMUST00000021447; ENSMUSP00000021447; ENSMUSG00000021051.
    GeneIDi26932.
    KEGGimmu:26932.
    UCSCiuc007nxe.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK088366 mRNA. Translation: BAC40306.1 .
    AK132432 mRNA. Translation: BAE21166.1 .
    BC085149 mRNA. Translation: AAH85149.1 .
    AK220163 mRNA. Translation: BAD90335.1 . Different initiation.
    U49728 mRNA. Translation: AAB37234.1 . Frameshift.
    CCDSi CCDS25983.1.
    RefSeqi NP_036154.1. NM_012024.2.
    XP_006515988.1. XM_006515925.1.
    UniGenei Mm.259626.
    Mm.440646.

    3D structure databases

    ProteinModelPortali Q61151.
    SMRi Q61151. Positions 51-423.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    IntActi Q61151. 3 interactions.
    MINTi MINT-4114181.

    PTM databases

    PhosphoSitei Q61151.

    Proteomic databases

    MaxQBi Q61151.
    PaxDbi Q61151.
    PRIDEi Q61151.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000021447 ; ENSMUSP00000021447 ; ENSMUSG00000021051 .
    GeneIDi 26932.
    KEGGi mmu:26932.
    UCSCi uc007nxe.1. mouse.

    Organism-specific databases

    CTDi 5529.
    MGIi MGI:1349473. Ppp2r5e.
    Rougei Search...

    Phylogenomic databases

    eggNOGi NOG264925.
    GeneTreei ENSGT00550000074525.
    HOGENOMi HOG000067326.
    HOVERGENi HBG000009.
    InParanoidi Q61151.
    KOi K11584.
    OMAi TEQAYPE.
    OrthoDBi EOG7C2R2S.
    PhylomeDBi Q61151.
    TreeFami TF105556.

    Enzyme and pathway databases

    Reactomei REACT_198961. Resolution of Sister Chromatid Cohesion.
    REACT_203336. Degradation of beta-catenin by the destruction complex.
    REACT_207679. Separation of Sister Chromatids.
    REACT_216784. disassembly of the destruction complex and recruitment of AXIN to the membrane.
    REACT_218396. Beta-catenin phosphorylation cascade.

    Miscellaneous databases

    NextBioi 304835.
    PROi Q61151.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q61151.
    Genevestigatori Q61151.

    Family and domain databases

    InterProi IPR016024. ARM-type_fold.
    IPR002554. PP2A_B56.
    [Graphical view ]
    PANTHERi PTHR10257. PTHR10257. 1 hit.
    Pfami PF01603. B56. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF028043. PP2A_B56. 1 hit.
    SUPFAMi SSF48371. SSF48371. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6J and NOD.
      Tissue: Skin and Thymus.
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6.
      Tissue: Brain.
    3. "Prediction of the coding sequences of mouse homologues of KIAA gene: II. The complete nucleotide sequences of 400 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries."
      Okazaki N., Kikuno R., Ohara R., Inamoto S., Aizawa H., Yuasa S., Nakajima D., Nagase T., Ohara O., Koga H.
      DNA Res. 10:35-48(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-436.
      Tissue: Embryonic tail.
    4. "p53-dependent association between cyclin G and the B' subunit of protein phosphatase 2A."
      Okamoto K., Kamibayashi C., Serrano M., Prives C., Mumby M.C., Beach D.
      Mol. Cell. Biol. 16:6593-6602(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 51-437.
      Tissue: Embryonic fibroblast.

    Entry informationi

    Entry namei2A5E_MOUSE
    AccessioniPrimary (citable) accession number: Q61151
    Secondary accession number(s): Q3V1I5, Q571M6, Q8C2M2
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 30, 2000
    Last sequence update: July 19, 2005
    Last modified: October 1, 2014
    This is version 101 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3