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Q61151

- 2A5E_MOUSE

UniProt

Q61151 - 2A5E_MOUSE

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Protein
Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit epsilon isoform
Gene
Ppp2r5e, Kiaa4006
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at transcript leveli

Functioni

The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. Interacts with cyclin G in vitro.

GO - Molecular functioni

  1. protein phosphatase type 2A regulator activity Source: InterPro
Complete GO annotation...

GO - Biological processi

  1. signal transduction Source: InterPro
Complete GO annotation...

Enzyme and pathway databases

ReactomeiREACT_198961. Resolution of Sister Chromatid Cohesion.
REACT_203336. Degradation of beta-catenin by the destruction complex.
REACT_207679. Separation of Sister Chromatids.
REACT_216784. disassembly of the destruction complex and recruitment of AXIN to the membrane.
REACT_218396. Beta-catenin phosphorylation cascade.

Names & Taxonomyi

Protein namesi
Recommended name:
Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit epsilon isoform
Alternative name(s):
PP2A B subunit isoform B'-epsilon
PP2A B subunit isoform B56-epsilon
PP2A B subunit isoform PR61-epsilon
PP2A B subunit isoform R5-epsilon
Gene namesi
Name:Ppp2r5e
Synonyms:Kiaa4006
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 12

Organism-specific databases

MGIiMGI:1349473. Ppp2r5e.

Subcellular locationi

Cytoplasm By similarity

GO - Cellular componenti

  1. cytoplasm Source: MGI
  2. intracellular membrane-bounded organelle Source: Ensembl
  3. protein phosphatase type 2A complex Source: InterPro
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11Removed By similarity
Chaini2 – 467466Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit epsilon isoform
PRO_0000071455Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylserine By similarity
Modified residuei30 – 301Phosphoserine By similarity
Modified residuei32 – 321Phosphoserine By similarity
Modified residuei34 – 341Phosphoserine By similarity

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

MaxQBiQ61151.
PaxDbiQ61151.
PRIDEiQ61151.

PTM databases

PhosphoSiteiQ61151.

Expressioni

Gene expression databases

BgeeiQ61151.
GenevestigatoriQ61151.

Interactioni

Subunit structurei

PP2A consists of a common heterodimeric core enzyme, composed of a 36 kDa catalytic subunit (subunit C) and a 65 kDa constant regulatory subunit (PR65 or subunit A), that associates with a variety of regulatory subunits. Proteins that associate with the core dimer include three families of regulatory subunits B (the R2/B/PR55/B55, R3/B''/PR72/PR130/PR59 and R5/B'/B56 families), the 48 kDa variable regulatory subunit, viral proteins, and cell signaling molecules. Interacts with SGOL1. Found in a complex with at least ARL2, PPP2CB; PPP2R1A, PPP2R2A, PPP2R5E and TBCD By similarity.

Protein-protein interaction databases

IntActiQ61151. 3 interactions.
MINTiMINT-4114181.

Structurei

3D structure databases

ProteinModelPortaliQ61151.
SMRiQ61151. Positions 51-423.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiNOG264925.
GeneTreeiENSGT00550000074525.
HOGENOMiHOG000067326.
HOVERGENiHBG000009.
InParanoidiQ61151.
KOiK11584.
OMAiTEQAYPE.
OrthoDBiEOG7C2R2S.
PhylomeDBiQ61151.
TreeFamiTF105556.

Family and domain databases

InterProiIPR016024. ARM-type_fold.
IPR002554. PP2A_B56.
[Graphical view]
PANTHERiPTHR10257. PTHR10257. 1 hit.
PfamiPF01603. B56. 1 hit.
[Graphical view]
PIRSFiPIRSF028043. PP2A_B56. 1 hit.
SUPFAMiSSF48371. SSF48371. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q61151-1 [UniParc]FASTAAdd to Basket

« Hide

MSSAPTTPPS VDKVDGFSRK SVRKARQKRS QSSSQFRSQG KPIELTPLPL    50
LKDVPTSEQP ELFLKKLQQC CVIFDFMDTL SDLKMKEYKR STLNELVDYI 100
TISRGCLTEQ TYPEVVRMVS CNIFRTLPPS DSNEFDPEED EPTLEASWPH 150
LQLVYEFFIR FLESQEFQPS IAKKYIDQKF VLQLLELFDS EDPRERDYLK 200
TVLHRIYGKF LGLRAFIRKQ INNIFLRFVY ETEHFNGVAE LLEILGSIIN 250
GFALPLKAEH KQFLVKVLIP LHTVRSLSLF HAQLAYCIVQ FLEKDPSLTE 300
PVIRGLMKFW PKTCSQKEVM FLGELEEILD VIEPSQFVKI QEPLFKQIAK 350
CVSSPHFQVA ERALYYWNNE YIMSLIEENS NVILPIMFSS LYRISKEHWN 400
PAIVALVYNV LKAFMEMNST MFDELTATYK SDRQREKKKE KEREELWKKL 450
EDLELKRGLR RDGIIPT 467
Length:467
Mass (Da):54,713
Last modified:July 19, 2005 - v3
Checksum:i77DA129F9A4EC6AC
GO

Sequence cautioni

The sequence AAB37234.1 differs from that shown. Reason: Frameshift at positions 162, 180 and 185.
The sequence BAD90335.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti74 – 741F → C in AAB37234. 1 Publication
Sequence conflicti162 – 1621L → W in AAB37234. 1 Publication
Sequence conflicti388 – 3881F → S in AAB37234. 1 Publication
Sequence conflicti409 – 4091N → T in AAB37234. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK088366 mRNA. Translation: BAC40306.1.
AK132432 mRNA. Translation: BAE21166.1.
BC085149 mRNA. Translation: AAH85149.1.
AK220163 mRNA. Translation: BAD90335.1. Different initiation.
U49728 mRNA. Translation: AAB37234.1. Frameshift.
CCDSiCCDS25983.1.
RefSeqiNP_036154.1. NM_012024.2.
XP_006515988.1. XM_006515925.1.
UniGeneiMm.259626.
Mm.440646.

Genome annotation databases

EnsembliENSMUST00000021447; ENSMUSP00000021447; ENSMUSG00000021051.
GeneIDi26932.
KEGGimmu:26932.
UCSCiuc007nxe.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK088366 mRNA. Translation: BAC40306.1 .
AK132432 mRNA. Translation: BAE21166.1 .
BC085149 mRNA. Translation: AAH85149.1 .
AK220163 mRNA. Translation: BAD90335.1 . Different initiation.
U49728 mRNA. Translation: AAB37234.1 . Frameshift.
CCDSi CCDS25983.1.
RefSeqi NP_036154.1. NM_012024.2.
XP_006515988.1. XM_006515925.1.
UniGenei Mm.259626.
Mm.440646.

3D structure databases

ProteinModelPortali Q61151.
SMRi Q61151. Positions 51-423.
ModBasei Search...

Protein-protein interaction databases

IntActi Q61151. 3 interactions.
MINTi MINT-4114181.

PTM databases

PhosphoSitei Q61151.

Proteomic databases

MaxQBi Q61151.
PaxDbi Q61151.
PRIDEi Q61151.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000021447 ; ENSMUSP00000021447 ; ENSMUSG00000021051 .
GeneIDi 26932.
KEGGi mmu:26932.
UCSCi uc007nxe.1. mouse.

Organism-specific databases

CTDi 5529.
MGIi MGI:1349473. Ppp2r5e.
Rougei Search...

Phylogenomic databases

eggNOGi NOG264925.
GeneTreei ENSGT00550000074525.
HOGENOMi HOG000067326.
HOVERGENi HBG000009.
InParanoidi Q61151.
KOi K11584.
OMAi TEQAYPE.
OrthoDBi EOG7C2R2S.
PhylomeDBi Q61151.
TreeFami TF105556.

Enzyme and pathway databases

Reactomei REACT_198961. Resolution of Sister Chromatid Cohesion.
REACT_203336. Degradation of beta-catenin by the destruction complex.
REACT_207679. Separation of Sister Chromatids.
REACT_216784. disassembly of the destruction complex and recruitment of AXIN to the membrane.
REACT_218396. Beta-catenin phosphorylation cascade.

Miscellaneous databases

NextBioi 304835.
PROi Q61151.
SOURCEi Search...

Gene expression databases

Bgeei Q61151.
Genevestigatori Q61151.

Family and domain databases

InterProi IPR016024. ARM-type_fold.
IPR002554. PP2A_B56.
[Graphical view ]
PANTHERi PTHR10257. PTHR10257. 1 hit.
Pfami PF01603. B56. 1 hit.
[Graphical view ]
PIRSFi PIRSF028043. PP2A_B56. 1 hit.
SUPFAMi SSF48371. SSF48371. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J and NOD.
    Tissue: Skin and Thymus.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6.
    Tissue: Brain.
  3. "Prediction of the coding sequences of mouse homologues of KIAA gene: II. The complete nucleotide sequences of 400 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries."
    Okazaki N., Kikuno R., Ohara R., Inamoto S., Aizawa H., Yuasa S., Nakajima D., Nagase T., Ohara O., Koga H.
    DNA Res. 10:35-48(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-436.
    Tissue: Embryonic tail.
  4. "p53-dependent association between cyclin G and the B' subunit of protein phosphatase 2A."
    Okamoto K., Kamibayashi C., Serrano M., Prives C., Mumby M.C., Beach D.
    Mol. Cell. Biol. 16:6593-6602(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 51-437.
    Tissue: Embryonic fibroblast.

Entry informationi

Entry namei2A5E_MOUSE
AccessioniPrimary (citable) accession number: Q61151
Secondary accession number(s): Q3V1I5, Q571M6, Q8C2M2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: July 19, 2005
Last modified: September 3, 2014
This is version 100 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi