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Q61147

- CERU_MOUSE

UniProt

Q61147 - CERU_MOUSE

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Protein

Ceruloplasmin

Gene
Cp
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at protein leveli

Functioni

Ceruloplasmin is a blue, copper-binding (6-7 atoms per molecule) glycoprotein. It has ferroxidase activity oxidizing Fe2+ to Fe3+ without releasing radical oxygen species. It is involved in iron transport across the cell membrane. Provides Cu2+ ions for the ascorbate-mediated deaminase degradation of the heparan sulfate chains of GPC1. May also play a role in fetal lung development or pulmonary antioxidant defense By similarity.

Catalytic activityi

4 Fe2+ + 4 H+ + O2 = 4 Fe3+ + 2 H2O.

Cofactori

Binds 6 copper ions per monomer By similarity.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi120 – 1201Copper 1; type 2 By similarity
Metal bindingi122 – 1221Copper 2; type 3 By similarity
Metal bindingi179 – 1791Copper 2; type 3 By similarity
Metal bindingi181 – 1811Copper 3; type 3 By similarity
Metal bindingi294 – 2941Copper 4; type 1 By similarity
Metal bindingi337 – 3371Copper 4; type 1 By similarity
Metal bindingi342 – 3421Copper 4; type 1 By similarity
Metal bindingi651 – 6511Copper 5; type 1 By similarity
Metal bindingi694 – 6941Copper 5; type 1 By similarity
Metal bindingi699 – 6991Copper 5; type 1 By similarity
Metal bindingi704 – 7041Copper 5; type 1 By similarity
Metal bindingi989 – 9891Copper 6; type 1 By similarity
Metal bindingi992 – 9921Copper 1; type 2 By similarity
Metal bindingi994 – 9941Copper 3; type 3 By similarity
Metal bindingi1034 – 10341Copper 3; type 3 By similarity
Metal bindingi1035 – 10351Copper 6; type 1 By similarity
Metal bindingi1036 – 10361Copper 2; type 3 By similarity
Metal bindingi1040 – 10401Copper 6; type 1 By similarity
Metal bindingi1045 – 10451Copper 6; type 1 By similarity

GO - Molecular functioni

  1. copper ion binding Source: MGI
  2. ferroxidase activity Source: MGI

GO - Biological processi

  1. cellular iron ion homeostasis Source: InterPro
  2. copper ion transport Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Copper transport, Ion transport, Transport

Keywords - Ligandi

Copper, Metal-binding

Enzyme and pathway databases

ReactomeiREACT_205755. Iron uptake and transport.

Names & Taxonomyi

Protein namesi
Recommended name:
Ceruloplasmin (EC:1.16.3.1)
Alternative name(s):
Ferroxidase
Gene namesi
Name:Cp
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 3

Organism-specific databases

MGIiMGI:88476. Cp.

Subcellular locationi

Secreted
Note: Colocalizes with GCP1 in secretory intracellular compartments By similarity.

GO - Cellular componenti

  1. extracellular space Source: MGI
  2. lysosomal membrane Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1919 By similarityAdd
BLAST
Chaini20 – 10611042CeruloplasminPRO_0000002913Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi138 – 1381N-linked (GlcNAc...)2 Publications
Disulfide bondi173 ↔ 199 By similarity
Glycosylationi226 – 2261N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi275 ↔ 356 By similarity
Glycosylationi396 – 3961N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi529 ↔ 555 By similarity
Glycosylationi583 – 5831N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi632 ↔ 713 By similarity
Glycosylationi757 – 7571N-linked (GlcNAc...)2 Publications
Disulfide bondi869 ↔ 895 By similarity
Glycosylationi921 – 9211N-linked (GlcNAc...) Reviewed prediction

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

MaxQBiQ61147.
PaxDbiQ61147.
PRIDEiQ61147.

PTM databases

PhosphoSiteiQ61147.

Expressioni

Tissue specificityi

Expressed in many tissues, including liver, eye and brain.1 Publication

Gene expression databases

ArrayExpressiQ61147.
BgeeiQ61147.
CleanExiMM_CP.
GenevestigatoriQ61147.

Interactioni

Protein-protein interaction databases

IntActiQ61147. 6 interactions.
MINTiMINT-4090622.

Structurei

3D structure databases

ProteinModelPortaliQ61147.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini20 – 356337F5/8 type A 1Add
BLAST
Domaini20 – 199180Plastocyanin-like 1Add
BLAST
Domaini208 – 356149Plastocyanin-like 2Add
BLAST
Domaini369 – 713345F5/8 type A 2Add
BLAST
Domaini369 – 555187Plastocyanin-like 3Add
BLAST
Domaini565 – 713149Plastocyanin-like 4Add
BLAST
Domaini725 – 1056332F5/8 type A 3Add
BLAST
Domaini725 – 895171Plastocyanin-like 5Add
BLAST
Domaini903 – 1056154Plastocyanin-like 6Add
BLAST

Sequence similaritiesi

Contains 3 F5/8 type A domains.

Keywords - Domaini

Repeat, Signal

Phylogenomic databases

eggNOGiNOG276067.
GeneTreeiENSGT00550000074552.
HOGENOMiHOG000231499.
HOVERGENiHBG003674.
KOiK13624.
OrthoDBiEOG7V49XN.
PhylomeDBiQ61147.
TreeFamiTF329807.

Family and domain databases

Gene3Di2.60.40.420. 6 hits.
InterProiIPR027150. CP.
IPR001117. Cu-oxidase.
IPR011706. Cu-oxidase_2.
IPR011707. Cu-oxidase_3.
IPR002355. Cu_oxidase_Cu_BS.
IPR008972. Cupredoxin.
[Graphical view]
PANTHERiPTHR10127:SF294. PTHR10127:SF294. 1 hit.
PfamiPF00394. Cu-oxidase. 1 hit.
PF07731. Cu-oxidase_2. 1 hit.
PF07732. Cu-oxidase_3. 3 hits.
[Graphical view]
SUPFAMiSSF49503. SSF49503. 6 hits.
PROSITEiPS00079. MULTICOPPER_OXIDASE1. 3 hits.
PS00080. MULTICOPPER_OXIDASE2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q61147-1 [UniParc]FASTAAdd to Basket

« Hide

MKFLLLSTFI FLYSSLALAR DKHYFIGITE AVWDYASGTE EKKLISVDTE     50
QSNFYLQNGP DRIGRKYKKA LYFEYTDGTF SKTIDKPAWL GFLGPVIKAE 100
VEDKVYVHLK NLASRIYTFH AHGVTYTKEY EGAVYPDNTT DFQRADDKVL 150
PGQQYVYVLH ANEPSPGEGD SNCVTRIYHS HVDAPKDIAS GLIGPLILCK 200
KGSLYKEKEK NIDQEFVLMF SVVDENLSWY LEDNIKTFCS EPEKVDKDNE 250
DFQESNRMYS INGYTFGSLP GLSMCAADRV KWYLFGMGNE VDVHSAFFHG 300
QALTSRNYQT DIINLFPATL IDAYMVAQNP GVWMLSCQNL NHLKAGLQAF 350
FQVRDCNKPS PEDNIQDRHV RHYYIAAEEV IWNYAPSGTD IFTGENLTAL 400
ESDSRVFFEQ GATRIGGSYK KMAYREYTDG SFTNRKQRGP DEEHLGILGP 450
VIWAEVGDTI KVTFHNKGQH PLSIQPMGVS FTAENEGTYY GPPGRSSQQA 500
ASHVAPKETF TYEWTVPKEM GPTYADPVCL SKMYYSGVDP TKDIFTGLIG 550
PMKICKKGSL LADGRQKDVD KEFYLFPTVF DENESLLLDD NIRMFTTAPD 600
QVDKEDEDFQ ESNKMHSMNG FMYGNQPGLN MCLGESIVWY LFSAGNEADV 650
HGIYFSGNTY LSKGERRDTA NLFPHKSLTL LMNPDTKGTF DVECLTTDHY 700
TGGMKQKYTV NQCQRQFEDF TVYLGERTYY VAAVEVEWDY SPSRAWEKEL 750
HHLQEQNVSN VFLDKEEFFI GSKYKKVVYR QFTDSSFREQ VKRRAEDEHL 800
GILGPPIHAN VGDKVKVVFK NMATRPYSIH AHGVKTESST VVPTLPGEVR 850
TYTWQIPERS GAGREDSACI PWAYYSTVDR VKDLYSGLIG PLIVCRKSYV 900
KVFSPKKKME FFLLFLVFDE NESWYLDDNI KTYSEHPEKV NKDNEEFLES 950
NKMHAINGKM FGNLQGLTMH VKDEVNWYVM GMGNEIDLHT VHFHGHSFQY 1000
KHRGVYSSDV FDLFPGTYQT LEMFPQTPGT WLLHCHVTDH VHAGMATTYT 1050
VLPVEQETKS G 1061
Length:1,061
Mass (Da):121,151
Last modified:December 4, 2007 - v2
Checksum:i16A2DAEA4F483886
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti354 – 3541R → Q in AAB07996. 1 Publication
Sequence conflicti361 – 3622PE → SK in AAB07996. 1 Publication
Sequence conflicti366 – 3683QDR → RGK in AAB07996. 1 Publication
Sequence conflicti389 – 3891T → I in AAB07996. 1 Publication
Sequence conflicti394 – 3963GEN → EEK in AAB07996. 1 Publication
Sequence conflicti400 – 4012LE → SG in AAB07996. 1 Publication
Sequence conflicti405 – 4051R → G in AAB07996. 1 Publication
Sequence conflicti437 – 4371Q → E in AAB07996. 1 Publication
Sequence conflicti471 – 4711P → H in AAB07996. 1 Publication
Sequence conflicti495 – 4951R → A in AAB07996. 1 Publication
Sequence conflicti537 – 5371G → A in AAB07996. 1 Publication
Sequence conflicti597 – 5971T → H in AAB07996. 1 Publication
Sequence conflicti627 – 6304PGLN → SWPH in AAB07996. 1 Publication
Sequence conflicti662 – 6621S → C in AAB07996. 1 Publication
Sequence conflicti666 – 6661R → E in AAB07996. 1 Publication
Sequence conflicti732 – 7321A → D in AAB07996. 1 Publication
Sequence conflicti796 – 7961E → EE in AAB07996. 1 Publication
Sequence conflicti850 – 8501R → A in AAB07996. 1 Publication
Sequence conflicti979 – 9791V → L in AAB07996. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U49430 mRNA. Translation: AAB07996.1.
BC062957 mRNA. Translation: AAH62957.1.
CCDSiCCDS38401.1.
RefSeqiNP_001263177.1. NM_001276248.1.
NP_031778.2. NM_007752.3.
UniGeneiMm.13787.

Genome annotation databases

EnsembliENSMUST00000091309; ENSMUSP00000088857; ENSMUSG00000003617.
GeneIDi12870.
KEGGimmu:12870.
UCSCiuc008orz.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U49430 mRNA. Translation: AAB07996.1 .
BC062957 mRNA. Translation: AAH62957.1 .
CCDSi CCDS38401.1.
RefSeqi NP_001263177.1. NM_001276248.1.
NP_031778.2. NM_007752.3.
UniGenei Mm.13787.

3D structure databases

ProteinModelPortali Q61147.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

IntActi Q61147. 6 interactions.
MINTi MINT-4090622.

PTM databases

PhosphoSitei Q61147.

Proteomic databases

MaxQBi Q61147.
PaxDbi Q61147.
PRIDEi Q61147.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000091309 ; ENSMUSP00000088857 ; ENSMUSG00000003617 .
GeneIDi 12870.
KEGGi mmu:12870.
UCSCi uc008orz.1. mouse.

Organism-specific databases

CTDi 1356.
MGIi MGI:88476. Cp.

Phylogenomic databases

eggNOGi NOG276067.
GeneTreei ENSGT00550000074552.
HOGENOMi HOG000231499.
HOVERGENi HBG003674.
KOi K13624.
OrthoDBi EOG7V49XN.
PhylomeDBi Q61147.
TreeFami TF329807.

Enzyme and pathway databases

Reactomei REACT_205755. Iron uptake and transport.

Miscellaneous databases

ChiTaRSi CP. mouse.
NextBioi 282456.
PROi Q61147.
SOURCEi Search...

Gene expression databases

ArrayExpressi Q61147.
Bgeei Q61147.
CleanExi MM_CP.
Genevestigatori Q61147.

Family and domain databases

Gene3Di 2.60.40.420. 6 hits.
InterProi IPR027150. CP.
IPR001117. Cu-oxidase.
IPR011706. Cu-oxidase_2.
IPR011707. Cu-oxidase_3.
IPR002355. Cu_oxidase_Cu_BS.
IPR008972. Cupredoxin.
[Graphical view ]
PANTHERi PTHR10127:SF294. PTHR10127:SF294. 1 hit.
Pfami PF00394. Cu-oxidase. 1 hit.
PF07731. Cu-oxidase_2. 1 hit.
PF07732. Cu-oxidase_3. 3 hits.
[Graphical view ]
SUPFAMi SSF49503. SSF49503. 6 hits.
PROSITEi PS00079. MULTICOPPER_OXIDASE1. 3 hits.
PS00080. MULTICOPPER_OXIDASE2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Ceruloplasmin gene expression in the murine central nervous system."
    Klomp L.W.J., Farhangrazi Z.S., Dugan L.L., Gitlin J.D.
    J. Clin. Invest. 98:207-215(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6.
    Tissue: Eye.
  3. "Proteome-wide characterization of N-glycosylation events by diagonal chromatography."
    Ghesquiere B., Van Damme J., Martens L., Vandekerckhove J., Gevaert K.
    J. Proteome Res. 5:2438-2447(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-138 AND ASN-757.
    Strain: C57BL/6.
    Tissue: Plasma.
  4. "Enhanced analysis of the mouse plasma proteome using cysteine-containing tryptic glycopeptides."
    Bernhard O.K., Kapp E.A., Simpson R.J.
    J. Proteome Res. 6:987-995(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-138 AND ASN-757.
    Strain: C57BL/6.
    Tissue: Plasma.

Entry informationi

Entry nameiCERU_MOUSE
AccessioniPrimary (citable) accession number: Q61147
Secondary accession number(s): Q6P5C8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: December 4, 2007
Last modified: September 3, 2014
This is version 115 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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