Reviewed,
UniProtKB/Swiss-Prot Q61143 (TRPC6_MOUSE)
Last modified
November 25, 2008.
Version 80.
History...
Clusters with 100%,
90%,
50% identity |
Documents (2) |
Third-party data |
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Names and origin
| Protein names | Recommended name: Short transient receptor potential channel 6 Short name=TrpC6 Alternative name(s): Calcium entry channel | ||||
| Gene names |
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| Organism | Mus musculus (Mouse) | ||||
| Taxonomic identifier | 10090 [NCBI] | ||||
| Taxonomic lineage | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus |
Protein attributes
| Sequence length | 930 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is not processed. |
| Protein existence | Evidence at transcript level. |
General annotation (Comments)
| Function | Thought to form a receptor-activated non-selective calcium permeant cation channel. Probably is operated by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases or G-protein coupled receptors. Activated by diacylglycerol (DAG) in a membrane-delimited fashion, independently of protein kinase C. Seems not to be activated by intracellular calcium store depletion. |
| Subcellular location | Membrane; Multi-pass membrane proteinProbable. |
| Tissue specificity | Lung and brain. |
| Post-translational modification | N-glycosylated. |
| Sequence similarities | Belongs to the transient receptor family. STrpC subfamily. Contains 3 ANK repeats. |
Ontologies
Keywords | |
|---|---|
| Biological process | Calcium transport Ion transport Transport |
| Cellular component | Membrane |
| Domain | ANK repeat Repeat Transmembrane |
| Ligand | Calcium |
| Molecular function | Calcium channel Ionic channel |
| PTM | Glycoprotein Phosphoprotein |
Gene Ontology (GO) | |
| Biological process | calcium ion transport Inferred from electronic annotation. Source: InterPro elevation of cytosolic calcium ion concentration Ref.1Inferred from direct assay. Source: MGI |
| Cellular component | integral to membrane Inferred from electronic annotation. Source: InterPro |
| Molecular function | calcium ion binding Inferred from electronic annotation. Source: UniProtKB-KW store-operated calcium channel activity Ref.3Inferred from direct assay. Source: MGI |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 930 | 930 | Short transient receptor potential channel 6 | PRO_0000215323 | |||||
Regions | |||||||||
| Topological domain | 1 – 437 | 437 | Cytoplasmic Potential | ||||||
| Transmembrane | 438 – 458 | 21 | Potential | ||||||
| Topological domain | 459 – 486 | 28 | Extracellular Potential | ||||||
| Transmembrane | 487 – 507 | 21 | Potential | ||||||
| Topological domain | 508 – 520 | 13 | Cytoplasmic Potential | ||||||
| Transmembrane | 521 – 541 | 21 | Potential | ||||||
| Topological domain | 542 – 591 | 50 | Extracellular Potential | ||||||
| Transmembrane | 592 – 612 | 21 | Potential | ||||||
| Topological domain | 613 – 635 | 23 | Cytoplasmic Potential | ||||||
| Transmembrane | 636 – 656 | 21 | Potential | ||||||
| Topological domain | 657 – 705 | 49 | Extracellular Potential | ||||||
| Transmembrane | 706 – 726 | 21 | Potential | ||||||
| Topological domain | 727 – 930 | 204 | Cytoplasmic Potential | ||||||
| Repeat | 131 – 160 | 30 | ANK 1 | ||||||
| Repeat | 162 – 188 | 27 | ANK 2 | ||||||
| Repeat | 217 – 246 | 30 | ANK 3 | ||||||
Amino acid modifications | |||||||||
| Modified residue | 69 | 1 | Phosphothreonine By similarity | ||||||
| Modified residue | 814 | 1 | Phosphoserine By similarity | ||||||
| Modified residue | 838 | 1 | Phosphoserine By similarity | ||||||
| Glycosylation | 560 | 1 | N-linked (GlcNAc...) Potential | ||||||
Experimental info | |||||||||
| Sequence conflict | 3 – 56 | 54 | Missing Ref.2 | ||||||
| Sequence conflict | 105 | 1 | V → A in AAC64394. Ref.2 | ||||||
| Sequence conflict | 114 | 1 | W → R in AAC64394. Ref.2 | ||||||
| Sequence conflict | 134 | 1 | N → D in AAC64394. Ref.2 | ||||||
| Sequence conflict | 184 | 1 | S → A in AAC64394. Ref.2 | ||||||
| Sequence conflict | 371 | 1 | D → Y in AAC64394. Ref.2 | ||||||
| Sequence conflict | 436 – 437 | 2 | PR → RG in AAC64394. Ref.2 | ||||||
| Sequence conflict | 905 | 1 | S → T in AAC64394. Ref.2 | ||||||
Sequences
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References
| [1] | "Cloning and expression of a novel mammalian homolog of Drosophila transient receptor potential (Trp) involved in calcium entry secondary to activation of receptors coupled by the Gq class of G protein." Boulay G., Zhu X., Peyton M., Jiang M., Hurst R., Stefani E., Birnbaumer L. J. Biol. Chem. 272:29672-29680(1997) [PubMed: 9368034] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Brain. |
| [2] | "Search for oncogenic regulators in an autocrine tumor model using differential display PCR: identification of novel candidate genes including the calcium channel mtrp6." Buess M., Engler O., Hirsch H.H., Moroni C. Oncogene 18:1487-1494(1999) [PubMed: 10050885] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Strain: DBA/2. |
| [3] | "trp, a novel mammalian gene family essential for agonist-activated capacitative Ca2+ entry." Zhu X., Jiang M., Peyton M., Boulay G., Hurst R., Stefani E., Birnbaumer L. Cell 85:661-671(1996) [PubMed: 8646775] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 631-739. Tissue: Brain. |
| + | Additional computationally mapped references. |
Cross-references
Sequence databases | |
|---|---|
| U49069 mRNA. Translation: AAC06146.1. AF057748 mRNA. Translation: AAC64394.1. | |
| UniGene | Mm.325086 |
3D structure databases | |
| ModBase | Search... |
PTM databases | |
| PhosphoSite | Q61143. |
Genome annotation databases | |
| Ensembl | ENSMUSG00000031997. Mus musculus. [Contig view] |
Organism-specific databases | |
| MGI | MGI:109523. Trpc6. |
Phylogenomic databases | |
| HOGENOM | Q61143. |
| HOVERGEN | Q61143. |
Gene expression databases | |
| ArrayExpress | Q61143. |
| GermOnline | ENSMUSG00000031997. Mus musculus. |
Family and domain databases | |
| InterPro | IPR002110. ANK. IPR005821. Ion_trans. IPR002153. Trans_rcpt. IPR013555. TRP_2. IPR004729. TRP_channel. IPR005462. TRP_channel6. [Graphical view] |
| Gene3D | G3DSA:1.25.40.20. ANK. 1 hit. |
| Pfam | PF00023. Ank. 3 hits. PF00520. Ion_trans. 1 hit. PF08344. TRP_2. 1 hit. [Graphical view] |
| PRINTS | PR01097. TRNSRECEPTRP. PR01647. TRPCHANNEL6. |
| SMART | SM00248. ANK. 3 hits. [Graphical view] |
| TIGRFAMs | TIGR00870. trp. 1 hit. |
| PROSITE | PS50297. ANK_REP_REGION. 1 hit. PS50088. ANK_REPEAT. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Other Resources | |
| LinkHub | Q61143. |
| SOURCE | Search... |
Entry information
| Entry name | TRPC6_MOUSE | ||||||||
| Accession | Primary (citable) accession number: Q61143 Secondary accession number(s): Q9Z2J1 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | HPI (Human Proteome Initiative) | ||||||||
Relevant documents
| MGD cross-references Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot |
| SIMILARITY comments Index of protein domains and families |

Clusters with


