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Protein

Short transient receptor potential channel 6

Gene

Trpc6

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Thought to form a receptor-activated non-selective calcium permeant cation channel. Probably is operated by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases or G-protein coupled receptors. Activated by diacylglycerol (DAG) in a membrane-delimited fashion, independently of protein kinase C. Seems not to be activated by intracellular calcium store depletion.By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionCalcium channel, Ion channel
Biological processCalcium transport, Ion transport, Transport
LigandCalcium

Enzyme and pathway databases

ReactomeiR-MMU-114508 Effects of PIP2 hydrolysis
R-MMU-139853 Elevation of cytosolic Ca2+ levels
R-MMU-3295583 TRP channels

Names & Taxonomyi

Protein namesi
Recommended name:
Short transient receptor potential channel 6By similarity
Short name:
TrpC61 Publication
Alternative name(s):
Calcium entry channel
Transient receptor protein 6
Short name:
TRP-6
Gene namesi
Name:Trpc61 PublicationImported
Synonyms:Trp6, Trrp6
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 9

Organism-specific databases

MGIiMGI:109523 Trpc6

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 437CytoplasmicSequence analysisAdd BLAST437
Transmembranei438 – 458HelicalSequence analysisAdd BLAST21
Topological domaini459 – 486ExtracellularSequence analysisAdd BLAST28
Transmembranei487 – 507HelicalSequence analysisAdd BLAST21
Topological domaini508 – 520CytoplasmicSequence analysisAdd BLAST13
Transmembranei521 – 541HelicalSequence analysisAdd BLAST21
Topological domaini542 – 591ExtracellularSequence analysisAdd BLAST50
Transmembranei592 – 612HelicalSequence analysisAdd BLAST21
Topological domaini613 – 635CytoplasmicSequence analysisAdd BLAST23
Transmembranei636 – 656HelicalSequence analysisAdd BLAST21
Topological domaini657 – 705ExtracellularSequence analysisAdd BLAST49
Transmembranei706 – 726HelicalSequence analysisAdd BLAST21
Topological domaini727 – 930CytoplasmicSequence analysisAdd BLAST204

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Chemistry databases

ChEMBLiCHEMBL1795081
GuidetoPHARMACOLOGYi491

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002153231 – 930Short transient receptor potential channel 6Add BLAST930

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi560N-linked (GlcNAc...) asparagineSequence analysis1
Modified residuei814PhosphoserineCombined sources1

Post-translational modificationi

Phosphorylated by FYN, leading to an increase of TRPC6 channel activity.1 Publication
N-glycosylated.

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

MaxQBiQ61143
PaxDbiQ61143
PRIDEiQ61143

PTM databases

iPTMnetiQ61143
PhosphoSitePlusiQ61143

Expressioni

Tissue specificityi

Lung and brain.

Gene expression databases

BgeeiENSMUSG00000031997
ExpressionAtlasiQ61143 baseline and differential
GenevisibleiQ61143 MM

Interactioni

Subunit structurei

Homodimer; forms channel complex. Interacts with MX1 and RNF24.By similarity

Binary interactionsi

WithEntry#Exp.IntActNotes
ORAI1Q96D312EBI-15563578,EBI-2291476From Homo sapiens.

GO - Molecular functioni

Protein-protein interaction databases

BioGridi204332, 1 interactor
DIPiDIP-60893N
IntActiQ61143, 3 interactors
STRINGi10090.ENSMUSP00000057965

Structurei

3D structure databases

ProteinModelPortaliQ61143
SMRiQ61143
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati96 – 125ANK 1Add BLAST30
Repeati131 – 160ANK 2Add BLAST30
Repeati162 – 188ANK 3Add BLAST27
Repeati217 – 246ANK 4Add BLAST30

Sequence similaritiesi

Keywords - Domaini

ANK repeat, Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3609 Eukaryota
ENOG410XQ0Y LUCA
GeneTreeiENSGT00760000119180
HOGENOMiHOG000020590
HOVERGENiHBG068337
InParanoidiQ61143
KOiK04969
OMAiNRGPAYM
OrthoDBiEOG091G01FB
TreeFamiTF313147

Family and domain databases

CDDicd00204 ANK, 1 hit
Gene3Di1.25.40.20, 1 hit
InterProiView protein in InterPro
IPR002110 Ankyrin_rpt
IPR020683 Ankyrin_rpt-contain_dom
IPR036770 Ankyrin_rpt-contain_sf
IPR005821 Ion_trans_dom
IPR004729 TRP_channel
IPR013555 TRP_dom
IPR005462 TRPC6_channel
IPR002153 TRPC_channel
PANTHERiPTHR10117 PTHR10117, 1 hit
PTHR10117:SF7 PTHR10117:SF7, 1 hit
PfamiView protein in Pfam
PF12796 Ank_2, 1 hit
PF00520 Ion_trans, 1 hit
PF08344 TRP_2, 1 hit
PRINTSiPR01097 TRNSRECEPTRP
PR01647 TRPCHANNEL6
SMARTiView protein in SMART
SM00248 ANK, 3 hits
SUPFAMiSSF48403 SSF48403, 1 hit
TIGRFAMsiTIGR00870 trp, 1 hit
PROSITEiView protein in PROSITE
PS50297 ANK_REP_REGION, 2 hits
PS50088 ANK_REPEAT, 1 hit

Sequencei

Sequence statusi: Complete.

Q61143-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSQSPRFVTR RGGSLKAAPG AGTRRNESQD YLLMDELGDD GYPQLPLPPY
60 70 80 90 100
GYYPSFRGNE NRLTHRRQTI LREKGRRLAN RGPAYMFNDH STSLSIEEER
110 120 130 140 150
FLDAAEYGNI PVVRKMLEEC HSLNVNCVDY MGQNALQLAV ANEHLEITEL
160 170 180 190 200
LLKKENLSRV GDALLLAISK GYVRIVEAIL NHPAFAEGKR LATSPSQSEL
210 220 230 240 250
QQDDFYAYDE DGTRFSHDVT PIILAAHCQE YEIVHTLLRK GARIERPHDY
260 270 280 290 300
FCKCTECSQK QKHDSFSHSR SRINAYKGLA SPAYLSLSSE DPVMTALELS
310 320 330 340 350
NELAVLANIE KEFKNDYRKL SMQCKDFVVG LLDLCRNTEE VEAILNGDAE
360 370 380 390 400
TRQPGDFGRP NLSRLKLAIK YEVKKFVAHP NCQQQLLSIW YENLSGLRQQ
410 420 430 440 450
TMAVKFLVVL AVAIGLPFLA LIYWCAPCSK MGKILRGPFM KFVAHAASFT
460 470 480 490 500
IFLGLLVMNA ADRFEGTKLL PNETSTDNAR QLFRMKTSCF SWMEMLIISW
510 520 530 540 550
VIGMIWAECK EIWTQGPKEY LFELWNMLDF GMLAIFAASF IARFMAFWHA
560 570 580 590 600
SKAQSIIDAN DTLKDLTKVT LGDNVKYYNL ARIKWDPTDP QIISEGLYAI
610 620 630 640 650
AVVLSFSRIA YILPANESFG PLQISLGRTV KDIFKFMVIF IMVFVAFMIG
660 670 680 690 700
MFNLYSYYIG AKQNEAFTTV EESFKTLFWA IFGLSEVKSV VINYNHKFIE
710 720 730 740 750
NIGYVLYGVY NVTMVIVLLN MLIAMINSSF QEIEDDADVE WKFARAKLWF
760 770 780 790 800
SYFEEGRTLP VPFNLVPSPK SLLYLLLKFK KWMCELIQGQ KQGFQEDAEM
810 820 830 840 850
NKRNEEKKFG ISGSHEDLSK FSLDKNQLAH NKQSSTRSSE DYHLNSFSNP
860 870 880 890 900
PRQYQKIMKR LIKRYVLQAQ IDKESDEVNE GELKEIKQDI SSLRYELLEE
910 920 930
KSQNTEDLAE LIRKLGERLS LEPKLEESRR
Length:930
Mass (Da):106,681
Last modified:July 27, 2011 - v3
Checksum:i9501C8D50FF33430
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti3 – 56Missing (PubMed:10050885).CuratedAdd BLAST54
Sequence conflicti105A → V in AAC06146 (PubMed:9368034).Curated1
Sequence conflicti114R → W in AAC06146 (PubMed:9368034).Curated1
Sequence conflicti134N → D in AAC64394 (PubMed:10050885).Curated1
Sequence conflicti184A → S in AAC06146 (PubMed:9368034).Curated1
Sequence conflicti371Y → D in AAC06146 (PubMed:9368034).Curated1
Sequence conflicti436 – 437RG → PR in AAC06146 (PubMed:9368034).Curated2
Sequence conflicti905T → S in AAC06146 (PubMed:9368034).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U49069 mRNA Translation: AAC06146.1
AF057748 mRNA Translation: AAC64394.1
CH466522 Genomic DNA Translation: EDL24958.1
BC141131 mRNA Translation: AAI41132.1
CCDSiCCDS22815.1
RefSeqiNP_038866.2, NM_013838.2
XP_006509913.1, XM_006509850.3
UniGeneiMm.325086

Genome annotation databases

EnsembliENSMUST00000050433; ENSMUSP00000057965; ENSMUSG00000031997
GeneIDi22068
KEGGimmu:22068
UCSCiuc009odl.1 mouse

Similar proteinsi

Entry informationi

Entry nameiTRPC6_MOUSE
AccessioniPrimary (citable) accession number: Q61143
Secondary accession number(s): B9EIW2, Q9Z2J1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: July 27, 2011
Last modified: June 20, 2018
This is version 163 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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