Short transient receptor potential channel 6

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Reviewed, UniProtKB/Swiss-Prot Q61143 (TRPC6_MOUSE)

Last modified November 25, 2008. Version 80. History...

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Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

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Names and origin

Protein names

Recommended name:
    Short transient receptor potential channel 6
      Short name=TrpC6
Alternative name(s):
    Calcium entry channel

Gene names

Name:	Trpc6
Synonyms:	Trp6, Trrp6

Organism

Mus musculus (Mouse)

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus

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Protein attributes

Sequence length	930 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at transcript level.

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General annotation (Comments)

Function	Thought to form a receptor-activated non-selective calcium permeant cation channel. Probably is operated by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases or G-protein coupled receptors. Activated by diacylglycerol (DAG) in a membrane-delimited fashion, independently of protein kinase C. Seems not to be activated by intracellular calcium store depletion.
Subcellular location	Membrane; Multi-pass membrane proteinProbable.
Tissue specificity	Lung and brain.
Post-translational modification	N-glycosylated.
Sequence similarities	Belongs to the transient receptor family. STrpC subfamily. Contains 3 ANK repeats.

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Ontologies

Keywords
Biological process	Calcium transport Ion transport Transport
Cellular component	Membrane
Domain	ANK repeat Repeat Transmembrane
Ligand	Calcium
Molecular function	Calcium channel Ionic channel
PTM	Glycoprotein Phosphoprotein
Gene Ontology (GO)
Biological process	calcium ion transport Inferred from electronic annotation. Source: InterPro elevation of cytosolic calcium ion concentration Ref.1 Inferred from direct assay. Source: MGI
Cellular component	integral to membrane Inferred from electronic annotation. Source: InterPro
Molecular function	calcium ion binding Inferred from electronic annotation. Source: UniProtKB-KW store-operated calcium channel activity Ref.3 Inferred from direct assay. Source: MGI
Complete GO annotation...

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Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – 930

930

Short transient receptor potential channel 6

PRO_0000215323

Regions

Topological domain

1 – 437

437

Cytoplasmic Potential

Transmembrane

438 – 458

Potential

Topological domain

459 – 486

Extracellular Potential

Transmembrane

487 – 507

Potential

Topological domain

508 – 520

Cytoplasmic Potential

Transmembrane

521 – 541

Potential

Topological domain

542 – 591

Extracellular Potential

Transmembrane

592 – 612

Potential

Topological domain

613 – 635

Cytoplasmic Potential

Transmembrane

636 – 656

Potential

Topological domain

657 – 705

Extracellular Potential

Transmembrane

706 – 726

Potential

Topological domain

727 – 930

204

Cytoplasmic Potential

Repeat

131 – 160

ANK 1

Repeat

162 – 188

ANK 2

Repeat

217 – 246

ANK 3

Amino acid modifications

Modified residue

Phosphothreonine By similarity

Modified residue

814

Phosphoserine By similarity

Modified residue

838

Phosphoserine By similarity

Glycosylation

560

N-linked (GlcNAc...) Potential

Experimental info

Sequence conflict

3 – 56

Missing Ref.2

Sequence conflict

105

V → A in AAC64394. Ref.2

Sequence conflict

114

W → R in AAC64394. Ref.2

Sequence conflict

134

N → D in AAC64394. Ref.2

Sequence conflict

184

S → A in AAC64394. Ref.2

Sequence conflict

371

D → Y in AAC64394. Ref.2

Sequence conflict

436 – 437

PR → RG in AAC64394. Ref.2

Sequence conflict

905

S → T in AAC64394. Ref.2

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Sequences

Sequence

Length

Mass (Da)

Tools

Q61143-1 [UniParc].

Last modified June 1, 1998. Version 2.
Checksum: CF21A426972732F3
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FASTA

930

106,733

        10         20         30         40         50         60 
MSQSPRFVTR RGGSLKAAPG AGTRRNESQD YLLMDELGDD GYPQLPLPPY GYYPSFRGNE 

        70         80         90        100        110        120 
NRLTHRRQTI LREKGRRLAN RGPAYMFNDH STSLSIEEER FLDAVEYGNI PVVWKMLEEC 

       130        140        150        160        170        180 
HSLNVNCVDY MGQNALQLAV ANEHLEITEL LLKKENLSRV GDALLLAISK GYVRIVEAIL 

       190        200        210        220        230        240 
NHPSFAEGKR LATSPSQSEL QQDDFYAYDE DGTRFSHDVT PIILAAHCQE YEIVHTLLRK 

       250        260        270        280        290        300 
GARIERPHDY FCKCTECSQK QKHDSFSHSR SRINAYKGLA SPAYLSLSSE DPVMTALELS 

       310        320        330        340        350        360 
NELAVLANIE KEFKNDYRKL SMQCKDFVVG LLDLCRNTEE VEAILNGDAE TRQPGDFGRP 

       370        380        390        400        410        420 
NLSRLKLAIK DEVKKFVAHP NCQQQLLSIW YENLSGLRQQ TMAVKFLVVL AVAIGLPFLA 

       430        440        450        460        470        480 
LIYWCAPCSK MGKILPRPFM KFVAHAASFT IFLGLLVMNA ADRFEGTKLL PNETSTDNAR 

       490        500        510        520        530        540 
QLFRMKTSCF SWMEMLIISW VIGMIWAECK EIWTQGPKEY LFELWNMLDF GMLAIFAASF 

       550        560        570        580        590        600 
IARFMAFWHA SKAQSIIDAN DTLKDLTKVT LGDNVKYYNL ARIKWDPTDP QIISEGLYAI 

       610        620        630        640        650        660 
AVVLSFSRIA YILPANESFG PLQISLGRTV KDIFKFMVIF IMVFVAFMIG MFNLYSYYIG 

       670        680        690        700        710        720 
AKQNEAFTTV EESFKTLFWA IFGLSEVKSV VINYNHKFIE NIGYVLYGVY NVTMVIVLLN 

       730        740        750        760        770        780 
MLIAMINSSF QEIEDDADVE WKFARAKLWF SYFEEGRTLP VPFNLVPSPK SLLYLLLKFK 

       790        800        810        820        830        840 
KWMCELIQGQ KQGFQEDAEM NKRNEEKKFG ISGSHEDLSK FSLDKNQLAH NKQSSTRSSE 

       850        860        870        880        890        900 
DYHLNSFSNP PRQYQKIMKR LIKRYVLQAQ IDKESDEVNE GELKEIKQDI SSLRYELLEE 

       910        920        930 
KSQNSEDLAE LIRKLGERLS LEPKLEESRR

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References

[1]	"Cloning and expression of a novel mammalian homolog of Drosophila transient receptor potential (Trp) involved in calcium entry secondary to activation of receptors coupled by the Gq class of G protein." Boulay G., Zhu X., Peyton M., Jiang M., Hurst R., Stefani E., Birnbaumer L. J. Biol. Chem. 272:29672-29680(1997) [PubMed: 9368034] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Brain.
[2]	"Search for oncogenic regulators in an autocrine tumor model using differential display PCR: identification of novel candidate genes including the calcium channel mtrp6." Buess M., Engler O., Hirsch H.H., Moroni C. Oncogene 18:1487-1494(1999) [PubMed: 10050885] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Strain: DBA/2.
[3]	"trp, a novel mammalian gene family essential for agonist-activated capacitative Ca2+ entry." Zhu X., Jiang M., Peyton M., Boulay G., Hurst R., Stefani E., Birnbaumer L. Cell 85:661-671(1996) [PubMed: 8646775] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 631-739. Tissue: Brain.
+	Additional computationally mapped references.

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Cross-references

Sequence databases
	U49069 mRNA. Translation: AAC06146.1. AF057748 mRNA. Translation: AAC64394.1.
UniGene	Mm.325086
3D structure databases
ModBase	Search...
PTM databases
PhosphoSite	Q61143.
Genome annotation databases
Ensembl	ENSMUSG00000031997. Mus musculus. [Contig view]
Organism-specific databases
MGI	MGI:109523. Trpc6.
Phylogenomic databases
HOGENOM	Q61143.
HOVERGEN	Q61143.
Gene expression databases
ArrayExpress	Q61143.
GermOnline	ENSMUSG00000031997. Mus musculus.
Family and domain databases
InterPro	IPR002110. ANK. IPR005821. Ion_trans. IPR002153. Trans_rcpt. IPR013555. TRP_2. IPR004729. TRP_channel. IPR005462. TRP_channel6. [Graphical view]
Gene3D	G3DSA:1.25.40.20. ANK. 1 hit.
Pfam	PF00023. Ank. 3 hits. PF00520. Ion_trans. 1 hit. PF08344. TRP_2. 1 hit. [Graphical view]
PRINTS	PR01097. TRNSRECEPTRP. PR01647. TRPCHANNEL6.
SMART	SM00248. ANK. 3 hits. [Graphical view]
TIGRFAMs	TIGR00870. trp. 1 hit.
PROSITE	PS50297. ANK_REP_REGION. 1 hit. PS50088. ANK_REPEAT. 1 hit. [Graphical view]
ProtoNet	Search...
Other Resources
LinkHub	Q61143.
SOURCE	Search...

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Entry information

Entry name

TRPC6_MOUSE

Accession

Primary (citable) accession number: Q61143
Secondary accession number(s): Q9Z2J1

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 30, 2000
Last sequence update:	June 1, 1998
Last modified:	November 25, 2008
This is version 80 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)

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Relevant documents

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

SIMILARITY comments

Index of protein domains and families

Names and origin

Protein attributes

General annotation (Comments)

Ontologies

Keywords

Gene Ontology (GO)

Sequence annotation (Features)

Molecule processing

Regions

Amino acid modifications

Experimental info

Sequences

References

Cross-references

Sequence databases

3D structure databases

PTM databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Gene expression databases

Family and domain databases

Other Resources

Entry information

Relevant documents