Short transient receptor potential channel 6

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Q61143 (TRPC6_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified May 1, 2013. Version 118. History...

Clusters with 100%, 90%, 50% identity |

Documents (2) |

Third-party data

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Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents Customize order

Names and origin

Protein names

Recommended name:
Short transient receptor potential channel 6
Short name=TrpC6

Alternative name(s):
Calcium entry channel
Transient receptor protein 6
Short name=TRP-6

Gene names

Name:	Trpc6
Synonyms:	Trp6, Trrp6

Organism

Mus musculus (Mouse) [Reference proteome]

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length	930 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Thought to form a receptor-activated non-selective calcium permeant cation channel. Probably is operated by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases or G-protein coupled receptors. Activated by diacylglycerol (DAG) in a membrane-delimited fashion, independently of protein kinase C. Seems not to be activated by intracellular calcium store depletion.
Subunit structure	Interacts with MX1 and RNF24 By similarity.
Subcellular location	Membrane; Multi-pass membrane protein Probable.
Tissue specificity	Lung and brain.
Post-translational modification	Phosphorylated by FYN, leading to an increase of TRPC6 channel activity. Ref.6 N-glycosylated.
Sequence similarities	Belongs to the transient receptor (TC 1.A.4) family. STrpC subfamily. TRPC6 sub-subfamily. [View classification] Contains 4 ANK repeats.

Ontologies

Keywords
Biological process	Calcium transport Ion transport Transport
Cellular component	Membrane
Domain	ANK repeat Repeat Transmembrane Transmembrane helix
Ligand	Calcium
Molecular function	Calcium channel Ion channel
PTM	Glycoprotein Phosphoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	elevation of cytosolic calcium ion concentration Inferred from direct assay Ref.1. Source: MGI positive regulation of calcium ion transport Inferred from sequence orthology PubMed 10998353. Source: MGI positive regulation of ion transmembrane transporter activity Inferred from sequence orthology PubMed 10998353. Source: MGI
Cellular_component	integral to plasma membrane Inferred from sequence alignment Ref.1. Source: MGI slit diaphragm Inferred from direct assay PubMed 15924139. Source: MGI
Molecular_function	inositol 1,4,5 trisphosphate binding Inferred from electronic annotation. Source: Compara store-operated calcium channel activity Inferred from direct assay Ref.5. Source: MGI
Complete GO annotation...

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – 930

930

Short transient receptor potential channel 6

PRO_0000215323

Regions

Topological domain

1 – 437

437

Cytoplasmic Potential

Transmembrane

438 – 458

Helical; Potential

Topological domain

459 – 486

Extracellular Potential

Transmembrane

487 – 507

Helical; Potential

Topological domain

508 – 520

Cytoplasmic Potential

Transmembrane

521 – 541

Helical; Potential

Topological domain

542 – 591

Extracellular Potential

Transmembrane

592 – 612

Helical; Potential

Topological domain

613 – 635

Cytoplasmic Potential

Transmembrane

636 – 656

Helical; Potential

Topological domain

657 – 705

Extracellular Potential

Transmembrane

706 – 726

Helical; Potential

Topological domain

727 – 930

204

Cytoplasmic Potential

Repeat

96 – 125

ANK 1

Repeat

131 – 160

ANK 2

Repeat

162 – 188

ANK 3

Repeat

217 – 246

ANK 4

Amino acid modifications

Modified residue

814

Phosphoserine By similarity

Glycosylation

560

N-linked (GlcNAc...) Potential

Experimental info

Sequence conflict

3 – 56

Missing Ref.2

Sequence conflict

105

A → V in AAC06146. Ref.1

Sequence conflict

114

R → W in AAC06146. Ref.1

Sequence conflict

134

N → D in AAC64394. Ref.2

Sequence conflict

184

A → S in AAC06146. Ref.1

Sequence conflict

371

Y → D in AAC06146. Ref.1

Sequence conflict

436 – 437

RG → PR in AAC06146. Ref.1

Sequence conflict

905

T → S in AAC06146. Ref.1

Sequences

Sequence

Length

Mass (Da)

Tools

Q61143 [UniParc].

Last modified July 27, 2011. Version 3.
Checksum: 9501C8D50FF33430
Show »

FASTA

930

106,681

        10         20         30         40         50         60 
MSQSPRFVTR RGGSLKAAPG AGTRRNESQD YLLMDELGDD GYPQLPLPPY GYYPSFRGNE 

        70         80         90        100        110        120 
NRLTHRRQTI LREKGRRLAN RGPAYMFNDH STSLSIEEER FLDAAEYGNI PVVRKMLEEC 

       130        140        150        160        170        180 
HSLNVNCVDY MGQNALQLAV ANEHLEITEL LLKKENLSRV GDALLLAISK GYVRIVEAIL 

       190        200        210        220        230        240 
NHPAFAEGKR LATSPSQSEL QQDDFYAYDE DGTRFSHDVT PIILAAHCQE YEIVHTLLRK 

       250        260        270        280        290        300 
GARIERPHDY FCKCTECSQK QKHDSFSHSR SRINAYKGLA SPAYLSLSSE DPVMTALELS 

       310        320        330        340        350        360 
NELAVLANIE KEFKNDYRKL SMQCKDFVVG LLDLCRNTEE VEAILNGDAE TRQPGDFGRP 

       370        380        390        400        410        420 
NLSRLKLAIK YEVKKFVAHP NCQQQLLSIW YENLSGLRQQ TMAVKFLVVL AVAIGLPFLA 

       430        440        450        460        470        480 
LIYWCAPCSK MGKILRGPFM KFVAHAASFT IFLGLLVMNA ADRFEGTKLL PNETSTDNAR 

       490        500        510        520        530        540 
QLFRMKTSCF SWMEMLIISW VIGMIWAECK EIWTQGPKEY LFELWNMLDF GMLAIFAASF 

       550        560        570        580        590        600 
IARFMAFWHA SKAQSIIDAN DTLKDLTKVT LGDNVKYYNL ARIKWDPTDP QIISEGLYAI 

       610        620        630        640        650        660 
AVVLSFSRIA YILPANESFG PLQISLGRTV KDIFKFMVIF IMVFVAFMIG MFNLYSYYIG 

       670        680        690        700        710        720 
AKQNEAFTTV EESFKTLFWA IFGLSEVKSV VINYNHKFIE NIGYVLYGVY NVTMVIVLLN 

       730        740        750        760        770        780 
MLIAMINSSF QEIEDDADVE WKFARAKLWF SYFEEGRTLP VPFNLVPSPK SLLYLLLKFK 

       790        800        810        820        830        840 
KWMCELIQGQ KQGFQEDAEM NKRNEEKKFG ISGSHEDLSK FSLDKNQLAH NKQSSTRSSE 

       850        860        870        880        890        900 
DYHLNSFSNP PRQYQKIMKR LIKRYVLQAQ IDKESDEVNE GELKEIKQDI SSLRYELLEE 

       910        920        930 
KSQNTEDLAE LIRKLGERLS LEPKLEESRR

« Hide

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Cloning and expression of a novel mammalian homolog of Drosophila transient receptor potential (Trp) involved in calcium entry secondary to activation of receptors coupled by the Gq class of G protein." Boulay G., Zhu X., Peyton M., Jiang M., Hurst R., Stefani E., Birnbaumer L. J. Biol. Chem. 272:29672-29680(1997) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Brain.
[2]	"Search for oncogenic regulators in an autocrine tumor model using differential display PCR: identification of novel candidate genes including the calcium channel mtrp6." Buess M., Engler O., Hirsch H.H., Moroni C. Oncogene 18:1487-1494(1999) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Strain: DBA/2.
[3]	Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C. Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Embryo.
[5]	"trp, a novel mammalian gene family essential for agonist-activated capacitative Ca2+ entry." Zhu X., Jiang M., Peyton M., Boulay G., Hurst R., Stefani E., Birnbaumer L. Cell 85:661-671(1996) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 631-739. Tissue: Brain.
[6]	"Regulation of TRPC6 channel activity by tyrosine phosphorylation." Hisatsune C., Kuroda Y., Nakamura K., Inoue T., Nakamura T., Michikawa T., Mizutani A., Mikoshiba K. J. Biol. Chem. 279:18887-18894(2004) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION BY FYN.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	U49069 mRNA. Translation: AAC06146.1. AF057748 mRNA. Translation: AAC64394.1. CH466522 Genomic DNA. Translation: EDL24958.1. BC141131 mRNA. Translation: AAI41132.1.
IPI	IPI00117824.
RefSeq	NP_038866.2. NM_013838.2.
UniGene	Mm.325086.
3D structure databases
ProteinModelPortal	Q61143.
SMR	Q61143. Positions 99-253.
ModBase	Search...
PTM databases
PhosphoSite	Q61143.
Proteomic databases
PaxDb	Q61143.
PRIDE	Q61143.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSMUST00000050433; ENSMUSP00000057965; ENSMUSG00000031997.
GeneID	22068.
KEGG	mmu:22068.
Organism-specific databases
CTD	7225.
MGI	MGI:109523. Trpc6.
Phylogenomic databases
eggNOG	NOG254238.
GeneTree	ENSGT00680000099764.
HOGENOM	HOG000020590.
HOVERGEN	HBG068337.
InParanoid	Q61143.
KO	K04969.
OMA	NRGPAYM.
Gene expression databases
Bgee	Q61143.
Genevestigator	Q61143.
GermOnline	ENSMUSG00000031997. Mus musculus.
Family and domain databases
Gene3D	1.25.40.20. 1 hit.
InterPro	IPR002110. Ankyrin_rpt. IPR020683. Ankyrin_rpt-contain_dom. IPR005821. Ion_trans_dom. IPR004729. TRP_channel. IPR013555. TRP_dom. IPR005462. TRPC6_channel. IPR002153. TRPC_channel. [Graphical view]
PANTHER	PTHR10117. PTHR10117. 1 hit. PTHR10117:SF7. PTHR10117:SF7. 1 hit.
Pfam	PF12796. Ank_2. 1 hit. PF00520. Ion_trans. 1 hit. PF08344. TRP_2. 1 hit. [Graphical view]
PRINTS	PR01097. TRNSRECEPTRP. PR01647. TRPCHANNEL6.
SMART	SM00248. ANK. 3 hits. [Graphical view]
SUPFAM	SSF48403. ANK. 1 hit.
TIGRFAMs	TIGR00870. trp. 1 hit.
PROSITE	PS50297. ANK_REP_REGION. 2 hits. PS50088. ANK_REPEAT. 1 hit. [Graphical view]
ProtoNet	Search...
Other
ChEMBL	CHEMBL1795081.
NextBio	301892.
SOURCE	Search...

Entry information

Entry name

TRPC6_MOUSE

Accession

Primary (citable) accession number: Q61143
Secondary accession number(s): B9EIW2, Q9Z2J1

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 30, 2000
Last sequence update:	July 27, 2011
Last modified:	May 1, 2013
This is version 118 of the entry and version 3 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Relevant documents

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

SIMILARITY comments

Index of protein domains and families

Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents

Preferred order of sections

Names and origin

Protein attributes

General annotation (Comments)

Ontologies

Sequence annotation (Features)

Molecule processing

Regions

Amino acid modifications

Experimental info

Sequences

References

Cross-references

Sequence databases

3D structure databases

PTM databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Gene expression databases

Family and domain databases

Other

Entry information

Relevant documents