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Q61143

- TRPC6_MOUSE

UniProt

Q61143 - TRPC6_MOUSE

Protein

Short transient receptor potential channel 6

Gene

Trpc6

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 131 (01 Oct 2014)
      Sequence version 3 (27 Jul 2011)
      Previous versions | rss
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    Functioni

    Thought to form a receptor-activated non-selective calcium permeant cation channel. Probably is operated by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases or G-protein coupled receptors. Activated by diacylglycerol (DAG) in a membrane-delimited fashion, independently of protein kinase C. Seems not to be activated by intracellular calcium store depletion.

    GO - Molecular functioni

    1. inositol 1,4,5 trisphosphate binding Source: Ensembl
    2. ion channel activity Source: MGI
    3. protein binding Source: MGI
    4. store-operated calcium channel activity Source: MGI

    GO - Biological processi

    1. aging Source: Ensembl
    2. cellular response to hydrogen peroxide Source: Ensembl
    3. cellular response to hypoxia Source: Ensembl
    4. positive regulation of calcium ion transport Source: MGI
    5. positive regulation of cytosolic calcium ion concentration Source: MGI
    6. positive regulation of ion transmembrane transporter activity Source: MGI

    Keywords - Molecular functioni

    Calcium channel, Ion channel

    Keywords - Biological processi

    Calcium transport, Ion transport, Transport

    Keywords - Ligandi

    Calcium

    Enzyme and pathway databases

    ReactomeiREACT_219232. Effects of PIP2 hydrolysis.
    REACT_227667. Elevation of cytosolic Ca2+ levels.
    REACT_227861. TRP channels.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Short transient receptor potential channel 6
    Short name:
    TrpC6
    Alternative name(s):
    Calcium entry channel
    Transient receptor protein 6
    Short name:
    TRP-6
    Gene namesi
    Name:Trpc6
    Synonyms:Trp6, Trrp6
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 9

    Organism-specific databases

    MGIiMGI:109523. Trpc6.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of plasma membrane Source: MGI
    2. plasma membrane Source: MGI
    3. slit diaphragm Source: MGI

    Keywords - Cellular componenti

    Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 930930Short transient receptor potential channel 6PRO_0000215323Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi560 – 5601N-linked (GlcNAc...)Sequence Analysis
    Modified residuei814 – 8141PhosphoserineBy similarity

    Post-translational modificationi

    Phosphorylated by FYN, leading to an increase of TRPC6 channel activity.1 Publication
    N-glycosylated.

    Keywords - PTMi

    Glycoprotein, Phosphoprotein

    Proteomic databases

    PaxDbiQ61143.
    PRIDEiQ61143.

    PTM databases

    PhosphoSiteiQ61143.

    Expressioni

    Tissue specificityi

    Lung and brain.

    Gene expression databases

    BgeeiQ61143.
    GenevestigatoriQ61143.

    Interactioni

    Subunit structurei

    Interacts with MX1 and RNF24.By similarity

    Protein-protein interaction databases

    DIPiDIP-60893N.

    Structurei

    3D structure databases

    ProteinModelPortaliQ61143.
    SMRiQ61143. Positions 99-253.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 437437CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini459 – 48628ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini508 – 52013CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini542 – 59150ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini613 – 63523CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini657 – 70549ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini727 – 930204CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei438 – 45821HelicalSequence AnalysisAdd
    BLAST
    Transmembranei487 – 50721HelicalSequence AnalysisAdd
    BLAST
    Transmembranei521 – 54121HelicalSequence AnalysisAdd
    BLAST
    Transmembranei592 – 61221HelicalSequence AnalysisAdd
    BLAST
    Transmembranei636 – 65621HelicalSequence AnalysisAdd
    BLAST
    Transmembranei706 – 72621HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Repeati96 – 12530ANK 1Add
    BLAST
    Repeati131 – 16030ANK 2Add
    BLAST
    Repeati162 – 18827ANK 3Add
    BLAST
    Repeati217 – 24630ANK 4Add
    BLAST

    Sequence similaritiesi

    Contains 4 ANK repeats.PROSITE-ProRule annotation

    Keywords - Domaini

    ANK repeat, Repeat, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG254238.
    GeneTreeiENSGT00680000099764.
    HOGENOMiHOG000020590.
    HOVERGENiHBG068337.
    InParanoidiQ61143.
    KOiK04969.
    OMAiNRGPAYM.
    OrthoDBiEOG77HDD1.
    TreeFamiTF313147.

    Family and domain databases

    Gene3Di1.25.40.20. 1 hit.
    InterProiIPR002110. Ankyrin_rpt.
    IPR020683. Ankyrin_rpt-contain_dom.
    IPR005821. Ion_trans_dom.
    IPR004729. TRP_channel.
    IPR013555. TRP_dom.
    IPR005462. TRPC6_channel.
    IPR002153. TRPC_channel.
    [Graphical view]
    PANTHERiPTHR10117. PTHR10117. 1 hit.
    PTHR10117:SF7. PTHR10117:SF7. 1 hit.
    PfamiPF12796. Ank_2. 1 hit.
    PF00520. Ion_trans. 1 hit.
    PF08344. TRP_2. 1 hit.
    [Graphical view]
    PRINTSiPR01097. TRNSRECEPTRP.
    PR01647. TRPCHANNEL6.
    SMARTiSM00248. ANK. 3 hits.
    [Graphical view]
    SUPFAMiSSF48403. SSF48403. 1 hit.
    TIGRFAMsiTIGR00870. trp. 1 hit.
    PROSITEiPS50297. ANK_REP_REGION. 2 hits.
    PS50088. ANK_REPEAT. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q61143-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSQSPRFVTR RGGSLKAAPG AGTRRNESQD YLLMDELGDD GYPQLPLPPY    50
    GYYPSFRGNE NRLTHRRQTI LREKGRRLAN RGPAYMFNDH STSLSIEEER 100
    FLDAAEYGNI PVVRKMLEEC HSLNVNCVDY MGQNALQLAV ANEHLEITEL 150
    LLKKENLSRV GDALLLAISK GYVRIVEAIL NHPAFAEGKR LATSPSQSEL 200
    QQDDFYAYDE DGTRFSHDVT PIILAAHCQE YEIVHTLLRK GARIERPHDY 250
    FCKCTECSQK QKHDSFSHSR SRINAYKGLA SPAYLSLSSE DPVMTALELS 300
    NELAVLANIE KEFKNDYRKL SMQCKDFVVG LLDLCRNTEE VEAILNGDAE 350
    TRQPGDFGRP NLSRLKLAIK YEVKKFVAHP NCQQQLLSIW YENLSGLRQQ 400
    TMAVKFLVVL AVAIGLPFLA LIYWCAPCSK MGKILRGPFM KFVAHAASFT 450
    IFLGLLVMNA ADRFEGTKLL PNETSTDNAR QLFRMKTSCF SWMEMLIISW 500
    VIGMIWAECK EIWTQGPKEY LFELWNMLDF GMLAIFAASF IARFMAFWHA 550
    SKAQSIIDAN DTLKDLTKVT LGDNVKYYNL ARIKWDPTDP QIISEGLYAI 600
    AVVLSFSRIA YILPANESFG PLQISLGRTV KDIFKFMVIF IMVFVAFMIG 650
    MFNLYSYYIG AKQNEAFTTV EESFKTLFWA IFGLSEVKSV VINYNHKFIE 700
    NIGYVLYGVY NVTMVIVLLN MLIAMINSSF QEIEDDADVE WKFARAKLWF 750
    SYFEEGRTLP VPFNLVPSPK SLLYLLLKFK KWMCELIQGQ KQGFQEDAEM 800
    NKRNEEKKFG ISGSHEDLSK FSLDKNQLAH NKQSSTRSSE DYHLNSFSNP 850
    PRQYQKIMKR LIKRYVLQAQ IDKESDEVNE GELKEIKQDI SSLRYELLEE 900
    KSQNTEDLAE LIRKLGERLS LEPKLEESRR 930
    Length:930
    Mass (Da):106,681
    Last modified:July 27, 2011 - v3
    Checksum:i9501C8D50FF33430
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti3 – 5654Missing(PubMed:10050885)CuratedAdd
    BLAST
    Sequence conflicti105 – 1051A → V in AAC06146. (PubMed:9368034)Curated
    Sequence conflicti114 – 1141R → W in AAC06146. (PubMed:9368034)Curated
    Sequence conflicti134 – 1341N → D in AAC64394. (PubMed:10050885)Curated
    Sequence conflicti184 – 1841A → S in AAC06146. (PubMed:9368034)Curated
    Sequence conflicti371 – 3711Y → D in AAC06146. (PubMed:9368034)Curated
    Sequence conflicti436 – 4372RG → PR in AAC06146. (PubMed:9368034)Curated
    Sequence conflicti905 – 9051T → S in AAC06146. (PubMed:9368034)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U49069 mRNA. Translation: AAC06146.1.
    AF057748 mRNA. Translation: AAC64394.1.
    CH466522 Genomic DNA. Translation: EDL24958.1.
    BC141131 mRNA. Translation: AAI41132.1.
    CCDSiCCDS22815.1.
    RefSeqiNP_038866.2. NM_013838.2.
    XP_006509913.1. XM_006509850.1.
    UniGeneiMm.325086.

    Genome annotation databases

    EnsembliENSMUST00000050433; ENSMUSP00000057965; ENSMUSG00000031997.
    GeneIDi22068.
    KEGGimmu:22068.
    UCSCiuc009odl.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U49069 mRNA. Translation: AAC06146.1 .
    AF057748 mRNA. Translation: AAC64394.1 .
    CH466522 Genomic DNA. Translation: EDL24958.1 .
    BC141131 mRNA. Translation: AAI41132.1 .
    CCDSi CCDS22815.1.
    RefSeqi NP_038866.2. NM_013838.2.
    XP_006509913.1. XM_006509850.1.
    UniGenei Mm.325086.

    3D structure databases

    ProteinModelPortali Q61143.
    SMRi Q61143. Positions 99-253.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    DIPi DIP-60893N.

    Chemistry

    ChEMBLi CHEMBL1795081.
    GuidetoPHARMACOLOGYi 491.

    PTM databases

    PhosphoSitei Q61143.

    Proteomic databases

    PaxDbi Q61143.
    PRIDEi Q61143.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000050433 ; ENSMUSP00000057965 ; ENSMUSG00000031997 .
    GeneIDi 22068.
    KEGGi mmu:22068.
    UCSCi uc009odl.1. mouse.

    Organism-specific databases

    CTDi 7225.
    MGIi MGI:109523. Trpc6.

    Phylogenomic databases

    eggNOGi NOG254238.
    GeneTreei ENSGT00680000099764.
    HOGENOMi HOG000020590.
    HOVERGENi HBG068337.
    InParanoidi Q61143.
    KOi K04969.
    OMAi NRGPAYM.
    OrthoDBi EOG77HDD1.
    TreeFami TF313147.

    Enzyme and pathway databases

    Reactomei REACT_219232. Effects of PIP2 hydrolysis.
    REACT_227667. Elevation of cytosolic Ca2+ levels.
    REACT_227861. TRP channels.

    Miscellaneous databases

    NextBioi 301892.
    PROi Q61143.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q61143.
    Genevestigatori Q61143.

    Family and domain databases

    Gene3Di 1.25.40.20. 1 hit.
    InterProi IPR002110. Ankyrin_rpt.
    IPR020683. Ankyrin_rpt-contain_dom.
    IPR005821. Ion_trans_dom.
    IPR004729. TRP_channel.
    IPR013555. TRP_dom.
    IPR005462. TRPC6_channel.
    IPR002153. TRPC_channel.
    [Graphical view ]
    PANTHERi PTHR10117. PTHR10117. 1 hit.
    PTHR10117:SF7. PTHR10117:SF7. 1 hit.
    Pfami PF12796. Ank_2. 1 hit.
    PF00520. Ion_trans. 1 hit.
    PF08344. TRP_2. 1 hit.
    [Graphical view ]
    PRINTSi PR01097. TRNSRECEPTRP.
    PR01647. TRPCHANNEL6.
    SMARTi SM00248. ANK. 3 hits.
    [Graphical view ]
    SUPFAMi SSF48403. SSF48403. 1 hit.
    TIGRFAMsi TIGR00870. trp. 1 hit.
    PROSITEi PS50297. ANK_REP_REGION. 2 hits.
    PS50088. ANK_REPEAT. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Cloning and expression of a novel mammalian homolog of Drosophila transient receptor potential (Trp) involved in calcium entry secondary to activation of receptors coupled by the Gq class of G protein."
      Boulay G., Zhu X., Peyton M., Jiang M., Hurst R., Stefani E., Birnbaumer L.
      J. Biol. Chem. 272:29672-29680(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Brain.
    2. "Search for oncogenic regulators in an autocrine tumor model using differential display PCR: identification of novel candidate genes including the calcium channel mtrp6."
      Buess M., Engler O., Hirsch H.H., Moroni C.
      Oncogene 18:1487-1494(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: DBA/2.
    3. Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
      Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Embryo.
    5. "trp, a novel mammalian gene family essential for agonist-activated capacitative Ca2+ entry."
      Zhu X., Jiang M., Peyton M., Boulay G., Hurst R., Stefani E., Birnbaumer L.
      Cell 85:661-671(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 631-739.
      Tissue: Brain.
    6. Cited for: PHOSPHORYLATION BY FYN.

    Entry informationi

    Entry nameiTRPC6_MOUSE
    AccessioniPrimary (citable) accession number: Q61143
    Secondary accession number(s): B9EIW2, Q9Z2J1
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 30, 2000
    Last sequence update: July 27, 2011
    Last modified: October 1, 2014
    This is version 131 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3