SubmitCancel

Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

Q61143

- TRPC6_MOUSE

UniProt

Q61143 - TRPC6_MOUSE

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein
Short transient receptor potential channel 6
Gene
Trpc6, Trp6, Trrp6
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Thought to form a receptor-activated non-selective calcium permeant cation channel. Probably is operated by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases or G-protein coupled receptors. Activated by diacylglycerol (DAG) in a membrane-delimited fashion, independently of protein kinase C. Seems not to be activated by intracellular calcium store depletion.

GO - Molecular functioni

  1. inositol 1,4,5 trisphosphate binding Source: Ensembl
  2. ion channel activity Source: MGI
  3. protein binding Source: MGI
  4. store-operated calcium channel activity Source: MGI
Complete GO annotation...

GO - Biological processi

  1. aging Source: Ensembl
  2. cellular response to hydrogen peroxide Source: Ensembl
  3. cellular response to hypoxia Source: Ensembl
  4. positive regulation of calcium ion transport Source: MGI
  5. positive regulation of cytosolic calcium ion concentration Source: MGI
  6. positive regulation of ion transmembrane transporter activity Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

Calcium channel, Ion channel

Keywords - Biological processi

Calcium transport, Ion transport, Transport

Keywords - Ligandi

Calcium

Enzyme and pathway databases

ReactomeiREACT_219232. Effects of PIP2 hydrolysis.
REACT_227667. Elevation of cytosolic Ca2+ levels.
REACT_227861. TRP channels.

Names & Taxonomyi

Protein namesi
Recommended name:
Short transient receptor potential channel 6
Short name:
TrpC6
Alternative name(s):
Calcium entry channel
Transient receptor protein 6
Short name:
TRP-6
Gene namesi
Name:Trpc6
Synonyms:Trp6, Trrp6
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 9

Organism-specific databases

MGIiMGI:109523. Trpc6.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 437437Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei438 – 45821Helical; Reviewed prediction
Add
BLAST
Topological domaini459 – 48628Extracellular Reviewed prediction
Add
BLAST
Transmembranei487 – 50721Helical; Reviewed prediction
Add
BLAST
Topological domaini508 – 52013Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei521 – 54121Helical; Reviewed prediction
Add
BLAST
Topological domaini542 – 59150Extracellular Reviewed prediction
Add
BLAST
Transmembranei592 – 61221Helical; Reviewed prediction
Add
BLAST
Topological domaini613 – 63523Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei636 – 65621Helical; Reviewed prediction
Add
BLAST
Topological domaini657 – 70549Extracellular Reviewed prediction
Add
BLAST
Transmembranei706 – 72621Helical; Reviewed prediction
Add
BLAST
Topological domaini727 – 930204Cytoplasmic Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. integral component of plasma membrane Source: MGI
  2. plasma membrane Source: MGI
  3. slit diaphragm Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 930930Short transient receptor potential channel 6
PRO_0000215323Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi560 – 5601N-linked (GlcNAc...) Reviewed prediction
Modified residuei814 – 8141Phosphoserine By similarity

Post-translational modificationi

Phosphorylated by FYN, leading to an increase of TRPC6 channel activity.1 Publication
N-glycosylated.

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbiQ61143.
PRIDEiQ61143.

PTM databases

PhosphoSiteiQ61143.

Expressioni

Tissue specificityi

Lung and brain.

Gene expression databases

BgeeiQ61143.
GenevestigatoriQ61143.

Interactioni

Subunit structurei

Interacts with MX1 and RNF24 By similarity.

Structurei

3D structure databases

ProteinModelPortaliQ61143.
SMRiQ61143. Positions 99-253.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati96 – 12530ANK 1
Add
BLAST
Repeati131 – 16030ANK 2
Add
BLAST
Repeati162 – 18827ANK 3
Add
BLAST
Repeati217 – 24630ANK 4
Add
BLAST

Sequence similaritiesi

Contains 4 ANK repeats.

Keywords - Domaini

ANK repeat, Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG254238.
GeneTreeiENSGT00680000099764.
HOGENOMiHOG000020590.
HOVERGENiHBG068337.
InParanoidiQ61143.
KOiK04969.
OMAiNRGPAYM.
OrthoDBiEOG77HDD1.
TreeFamiTF313147.

Family and domain databases

Gene3Di1.25.40.20. 1 hit.
InterProiIPR002110. Ankyrin_rpt.
IPR020683. Ankyrin_rpt-contain_dom.
IPR005821. Ion_trans_dom.
IPR004729. TRP_channel.
IPR013555. TRP_dom.
IPR005462. TRPC6_channel.
IPR002153. TRPC_channel.
[Graphical view]
PANTHERiPTHR10117. PTHR10117. 1 hit.
PTHR10117:SF7. PTHR10117:SF7. 1 hit.
PfamiPF12796. Ank_2. 1 hit.
PF00520. Ion_trans. 1 hit.
PF08344. TRP_2. 1 hit.
[Graphical view]
PRINTSiPR01097. TRNSRECEPTRP.
PR01647. TRPCHANNEL6.
SMARTiSM00248. ANK. 3 hits.
[Graphical view]
SUPFAMiSSF48403. SSF48403. 1 hit.
TIGRFAMsiTIGR00870. trp. 1 hit.
PROSITEiPS50297. ANK_REP_REGION. 2 hits.
PS50088. ANK_REPEAT. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q61143-1 [UniParc]FASTAAdd to Basket

« Hide

MSQSPRFVTR RGGSLKAAPG AGTRRNESQD YLLMDELGDD GYPQLPLPPY    50
GYYPSFRGNE NRLTHRRQTI LREKGRRLAN RGPAYMFNDH STSLSIEEER 100
FLDAAEYGNI PVVRKMLEEC HSLNVNCVDY MGQNALQLAV ANEHLEITEL 150
LLKKENLSRV GDALLLAISK GYVRIVEAIL NHPAFAEGKR LATSPSQSEL 200
QQDDFYAYDE DGTRFSHDVT PIILAAHCQE YEIVHTLLRK GARIERPHDY 250
FCKCTECSQK QKHDSFSHSR SRINAYKGLA SPAYLSLSSE DPVMTALELS 300
NELAVLANIE KEFKNDYRKL SMQCKDFVVG LLDLCRNTEE VEAILNGDAE 350
TRQPGDFGRP NLSRLKLAIK YEVKKFVAHP NCQQQLLSIW YENLSGLRQQ 400
TMAVKFLVVL AVAIGLPFLA LIYWCAPCSK MGKILRGPFM KFVAHAASFT 450
IFLGLLVMNA ADRFEGTKLL PNETSTDNAR QLFRMKTSCF SWMEMLIISW 500
VIGMIWAECK EIWTQGPKEY LFELWNMLDF GMLAIFAASF IARFMAFWHA 550
SKAQSIIDAN DTLKDLTKVT LGDNVKYYNL ARIKWDPTDP QIISEGLYAI 600
AVVLSFSRIA YILPANESFG PLQISLGRTV KDIFKFMVIF IMVFVAFMIG 650
MFNLYSYYIG AKQNEAFTTV EESFKTLFWA IFGLSEVKSV VINYNHKFIE 700
NIGYVLYGVY NVTMVIVLLN MLIAMINSSF QEIEDDADVE WKFARAKLWF 750
SYFEEGRTLP VPFNLVPSPK SLLYLLLKFK KWMCELIQGQ KQGFQEDAEM 800
NKRNEEKKFG ISGSHEDLSK FSLDKNQLAH NKQSSTRSSE DYHLNSFSNP 850
PRQYQKIMKR LIKRYVLQAQ IDKESDEVNE GELKEIKQDI SSLRYELLEE 900
KSQNTEDLAE LIRKLGERLS LEPKLEESRR 930
Length:930
Mass (Da):106,681
Last modified:July 27, 2011 - v3
Checksum:i9501C8D50FF33430
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti3 – 5654Missing1 Publication
Add
BLAST
Sequence conflicti105 – 1051A → V in AAC06146. 1 Publication
Sequence conflicti114 – 1141R → W in AAC06146. 1 Publication
Sequence conflicti134 – 1341N → D in AAC64394. 1 Publication
Sequence conflicti184 – 1841A → S in AAC06146. 1 Publication
Sequence conflicti371 – 3711Y → D in AAC06146. 1 Publication
Sequence conflicti436 – 4372RG → PR in AAC06146. 1 Publication
Sequence conflicti905 – 9051T → S in AAC06146. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U49069 mRNA. Translation: AAC06146.1.
AF057748 mRNA. Translation: AAC64394.1.
CH466522 Genomic DNA. Translation: EDL24958.1.
BC141131 mRNA. Translation: AAI41132.1.
CCDSiCCDS22815.1.
RefSeqiNP_038866.2. NM_013838.2.
XP_006509913.1. XM_006509850.1.
UniGeneiMm.325086.

Genome annotation databases

EnsembliENSMUST00000050433; ENSMUSP00000057965; ENSMUSG00000031997.
GeneIDi22068.
KEGGimmu:22068.
UCSCiuc009odl.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U49069 mRNA. Translation: AAC06146.1 .
AF057748 mRNA. Translation: AAC64394.1 .
CH466522 Genomic DNA. Translation: EDL24958.1 .
BC141131 mRNA. Translation: AAI41132.1 .
CCDSi CCDS22815.1.
RefSeqi NP_038866.2. NM_013838.2.
XP_006509913.1. XM_006509850.1.
UniGenei Mm.325086.

3D structure databases

ProteinModelPortali Q61143.
SMRi Q61143. Positions 99-253.
ModBasei Search...

Chemistry

ChEMBLi CHEMBL1795081.
GuidetoPHARMACOLOGYi 491.

PTM databases

PhosphoSitei Q61143.

Proteomic databases

PaxDbi Q61143.
PRIDEi Q61143.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000050433 ; ENSMUSP00000057965 ; ENSMUSG00000031997 .
GeneIDi 22068.
KEGGi mmu:22068.
UCSCi uc009odl.1. mouse.

Organism-specific databases

CTDi 7225.
MGIi MGI:109523. Trpc6.

Phylogenomic databases

eggNOGi NOG254238.
GeneTreei ENSGT00680000099764.
HOGENOMi HOG000020590.
HOVERGENi HBG068337.
InParanoidi Q61143.
KOi K04969.
OMAi NRGPAYM.
OrthoDBi EOG77HDD1.
TreeFami TF313147.

Enzyme and pathway databases

Reactomei REACT_219232. Effects of PIP2 hydrolysis.
REACT_227667. Elevation of cytosolic Ca2+ levels.
REACT_227861. TRP channels.

Miscellaneous databases

NextBioi 301892.
PROi Q61143.
SOURCEi Search...

Gene expression databases

Bgeei Q61143.
Genevestigatori Q61143.

Family and domain databases

Gene3Di 1.25.40.20. 1 hit.
InterProi IPR002110. Ankyrin_rpt.
IPR020683. Ankyrin_rpt-contain_dom.
IPR005821. Ion_trans_dom.
IPR004729. TRP_channel.
IPR013555. TRP_dom.
IPR005462. TRPC6_channel.
IPR002153. TRPC_channel.
[Graphical view ]
PANTHERi PTHR10117. PTHR10117. 1 hit.
PTHR10117:SF7. PTHR10117:SF7. 1 hit.
Pfami PF12796. Ank_2. 1 hit.
PF00520. Ion_trans. 1 hit.
PF08344. TRP_2. 1 hit.
[Graphical view ]
PRINTSi PR01097. TRNSRECEPTRP.
PR01647. TRPCHANNEL6.
SMARTi SM00248. ANK. 3 hits.
[Graphical view ]
SUPFAMi SSF48403. SSF48403. 1 hit.
TIGRFAMsi TIGR00870. trp. 1 hit.
PROSITEi PS50297. ANK_REP_REGION. 2 hits.
PS50088. ANK_REPEAT. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning and expression of a novel mammalian homolog of Drosophila transient receptor potential (Trp) involved in calcium entry secondary to activation of receptors coupled by the Gq class of G protein."
    Boulay G., Zhu X., Peyton M., Jiang M., Hurst R., Stefani E., Birnbaumer L.
    J. Biol. Chem. 272:29672-29680(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Brain.
  2. "Search for oncogenic regulators in an autocrine tumor model using differential display PCR: identification of novel candidate genes including the calcium channel mtrp6."
    Buess M., Engler O., Hirsch H.H., Moroni C.
    Oncogene 18:1487-1494(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: DBA/2.
  3. Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
    Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Embryo.
  5. "trp, a novel mammalian gene family essential for agonist-activated capacitative Ca2+ entry."
    Zhu X., Jiang M., Peyton M., Boulay G., Hurst R., Stefani E., Birnbaumer L.
    Cell 85:661-671(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 631-739.
    Tissue: Brain.
  6. Cited for: PHOSPHORYLATION BY FYN.

Entry informationi

Entry nameiTRPC6_MOUSE
AccessioniPrimary (citable) accession number: Q61143
Secondary accession number(s): B9EIW2, Q9Z2J1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: July 27, 2011
Last modified: September 3, 2014
This is version 130 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi