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Q61143

- TRPC6_MOUSE

UniProt

Q61143 - TRPC6_MOUSE

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Protein

Short transient receptor potential channel 6

Gene

Trpc6

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Thought to form a receptor-activated non-selective calcium permeant cation channel. Probably is operated by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases or G-protein coupled receptors. Activated by diacylglycerol (DAG) in a membrane-delimited fashion, independently of protein kinase C. Seems not to be activated by intracellular calcium store depletion.

GO - Molecular functioni

  1. inositol 1,4,5 trisphosphate binding Source: Ensembl
  2. ion channel activity Source: MGI
  3. store-operated calcium channel activity Source: MGI

GO - Biological processi

  1. aging Source: Ensembl
  2. cellular response to hydrogen peroxide Source: Ensembl
  3. cellular response to hypoxia Source: Ensembl
  4. positive regulation of calcium ion transport Source: MGI
  5. positive regulation of cytosolic calcium ion concentration Source: MGI
  6. positive regulation of ion transmembrane transporter activity Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

Calcium channel, Ion channel

Keywords - Biological processi

Calcium transport, Ion transport, Transport

Keywords - Ligandi

Calcium

Enzyme and pathway databases

ReactomeiREACT_219232. Effects of PIP2 hydrolysis.
REACT_227667. Elevation of cytosolic Ca2+ levels.
REACT_227861. TRP channels.

Names & Taxonomyi

Protein namesi
Recommended name:
Short transient receptor potential channel 6
Short name:
TrpC6
Alternative name(s):
Calcium entry channel
Transient receptor protein 6
Short name:
TRP-6
Gene namesi
Name:Trpc6
Synonyms:Trp6, Trrp6
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 9

Organism-specific databases

MGIiMGI:109523. Trpc6.

Subcellular locationi

GO - Cellular componenti

  1. integral component of plasma membrane Source: MGI
  2. plasma membrane Source: MGI
  3. slit diaphragm Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 930930Short transient receptor potential channel 6PRO_0000215323Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi560 – 5601N-linked (GlcNAc...)Sequence Analysis
Modified residuei814 – 8141PhosphoserineBy similarity

Post-translational modificationi

Phosphorylated by FYN, leading to an increase of TRPC6 channel activity.1 Publication
N-glycosylated.

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbiQ61143.
PRIDEiQ61143.

PTM databases

PhosphoSiteiQ61143.

Expressioni

Tissue specificityi

Lung and brain.

Gene expression databases

BgeeiQ61143.
GenevestigatoriQ61143.

Interactioni

Subunit structurei

Interacts with MX1 and RNF24.By similarity

Protein-protein interaction databases

DIPiDIP-60893N.

Structurei

3D structure databases

ProteinModelPortaliQ61143.
SMRiQ61143. Positions 99-253.
ModBaseiSearch...
MobiDBiSearch...

Topological domain

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 437437CytoplasmicSequence AnalysisAdd
BLAST
Topological domaini459 – 48628ExtracellularSequence AnalysisAdd
BLAST
Topological domaini508 – 52013CytoplasmicSequence AnalysisAdd
BLAST
Topological domaini542 – 59150ExtracellularSequence AnalysisAdd
BLAST
Topological domaini613 – 63523CytoplasmicSequence AnalysisAdd
BLAST
Topological domaini657 – 70549ExtracellularSequence AnalysisAdd
BLAST
Topological domaini727 – 930204CytoplasmicSequence AnalysisAdd
BLAST

Transmembrane

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei438 – 45821HelicalSequence AnalysisAdd
BLAST
Transmembranei487 – 50721HelicalSequence AnalysisAdd
BLAST
Transmembranei521 – 54121HelicalSequence AnalysisAdd
BLAST
Transmembranei592 – 61221HelicalSequence AnalysisAdd
BLAST
Transmembranei636 – 65621HelicalSequence AnalysisAdd
BLAST
Transmembranei706 – 72621HelicalSequence AnalysisAdd
BLAST

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati96 – 12530ANK 1Add
BLAST
Repeati131 – 16030ANK 2Add
BLAST
Repeati162 – 18827ANK 3Add
BLAST
Repeati217 – 24630ANK 4Add
BLAST

Sequence similaritiesi

Contains 4 ANK repeats.PROSITE-ProRule annotation

Keywords - Domaini

ANK repeat, Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG254238.
GeneTreeiENSGT00760000119180.
HOGENOMiHOG000020590.
HOVERGENiHBG068337.
InParanoidiQ61143.
KOiK04969.
OMAiNRGPAYM.
OrthoDBiEOG77HDD1.
TreeFamiTF313147.

Family and domain databases

Gene3Di1.25.40.20. 1 hit.
InterProiIPR002110. Ankyrin_rpt.
IPR020683. Ankyrin_rpt-contain_dom.
IPR005821. Ion_trans_dom.
IPR004729. TRP_channel.
IPR013555. TRP_dom.
IPR005462. TRPC6_channel.
IPR002153. TRPC_channel.
[Graphical view]
PANTHERiPTHR10117. PTHR10117. 1 hit.
PTHR10117:SF7. PTHR10117:SF7. 1 hit.
PfamiPF12796. Ank_2. 1 hit.
PF00520. Ion_trans. 1 hit.
PF08344. TRP_2. 1 hit.
[Graphical view]
PRINTSiPR01097. TRNSRECEPTRP.
PR01647. TRPCHANNEL6.
SMARTiSM00248. ANK. 3 hits.
[Graphical view]
SUPFAMiSSF48403. SSF48403. 1 hit.
TIGRFAMsiTIGR00870. trp. 1 hit.
PROSITEiPS50297. ANK_REP_REGION. 2 hits.
PS50088. ANK_REPEAT. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q61143-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSQSPRFVTR RGGSLKAAPG AGTRRNESQD YLLMDELGDD GYPQLPLPPY
60 70 80 90 100
GYYPSFRGNE NRLTHRRQTI LREKGRRLAN RGPAYMFNDH STSLSIEEER
110 120 130 140 150
FLDAAEYGNI PVVRKMLEEC HSLNVNCVDY MGQNALQLAV ANEHLEITEL
160 170 180 190 200
LLKKENLSRV GDALLLAISK GYVRIVEAIL NHPAFAEGKR LATSPSQSEL
210 220 230 240 250
QQDDFYAYDE DGTRFSHDVT PIILAAHCQE YEIVHTLLRK GARIERPHDY
260 270 280 290 300
FCKCTECSQK QKHDSFSHSR SRINAYKGLA SPAYLSLSSE DPVMTALELS
310 320 330 340 350
NELAVLANIE KEFKNDYRKL SMQCKDFVVG LLDLCRNTEE VEAILNGDAE
360 370 380 390 400
TRQPGDFGRP NLSRLKLAIK YEVKKFVAHP NCQQQLLSIW YENLSGLRQQ
410 420 430 440 450
TMAVKFLVVL AVAIGLPFLA LIYWCAPCSK MGKILRGPFM KFVAHAASFT
460 470 480 490 500
IFLGLLVMNA ADRFEGTKLL PNETSTDNAR QLFRMKTSCF SWMEMLIISW
510 520 530 540 550
VIGMIWAECK EIWTQGPKEY LFELWNMLDF GMLAIFAASF IARFMAFWHA
560 570 580 590 600
SKAQSIIDAN DTLKDLTKVT LGDNVKYYNL ARIKWDPTDP QIISEGLYAI
610 620 630 640 650
AVVLSFSRIA YILPANESFG PLQISLGRTV KDIFKFMVIF IMVFVAFMIG
660 670 680 690 700
MFNLYSYYIG AKQNEAFTTV EESFKTLFWA IFGLSEVKSV VINYNHKFIE
710 720 730 740 750
NIGYVLYGVY NVTMVIVLLN MLIAMINSSF QEIEDDADVE WKFARAKLWF
760 770 780 790 800
SYFEEGRTLP VPFNLVPSPK SLLYLLLKFK KWMCELIQGQ KQGFQEDAEM
810 820 830 840 850
NKRNEEKKFG ISGSHEDLSK FSLDKNQLAH NKQSSTRSSE DYHLNSFSNP
860 870 880 890 900
PRQYQKIMKR LIKRYVLQAQ IDKESDEVNE GELKEIKQDI SSLRYELLEE
910 920 930
KSQNTEDLAE LIRKLGERLS LEPKLEESRR
Length:930
Mass (Da):106,681
Last modified:July 27, 2011 - v3
Checksum:i9501C8D50FF33430
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti3 – 5654Missing(PubMed:10050885)CuratedAdd
BLAST
Sequence conflicti105 – 1051A → V in AAC06146. (PubMed:9368034)Curated
Sequence conflicti114 – 1141R → W in AAC06146. (PubMed:9368034)Curated
Sequence conflicti134 – 1341N → D in AAC64394. (PubMed:10050885)Curated
Sequence conflicti184 – 1841A → S in AAC06146. (PubMed:9368034)Curated
Sequence conflicti371 – 3711Y → D in AAC06146. (PubMed:9368034)Curated
Sequence conflicti436 – 4372RG → PR in AAC06146. (PubMed:9368034)Curated
Sequence conflicti905 – 9051T → S in AAC06146. (PubMed:9368034)Curated

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U49069 mRNA. Translation: AAC06146.1.
AF057748 mRNA. Translation: AAC64394.1.
CH466522 Genomic DNA. Translation: EDL24958.1.
BC141131 mRNA. Translation: AAI41132.1.
CCDSiCCDS22815.1.
RefSeqiNP_038866.2. NM_013838.2.
XP_006509913.1. XM_006509850.1.
UniGeneiMm.325086.

Genome annotation databases

EnsembliENSMUST00000050433; ENSMUSP00000057965; ENSMUSG00000031997.
GeneIDi22068.
KEGGimmu:22068.
UCSCiuc009odl.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U49069 mRNA. Translation: AAC06146.1 .
AF057748 mRNA. Translation: AAC64394.1 .
CH466522 Genomic DNA. Translation: EDL24958.1 .
BC141131 mRNA. Translation: AAI41132.1 .
CCDSi CCDS22815.1.
RefSeqi NP_038866.2. NM_013838.2.
XP_006509913.1. XM_006509850.1.
UniGenei Mm.325086.

3D structure databases

ProteinModelPortali Q61143.
SMRi Q61143. Positions 99-253.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

DIPi DIP-60893N.

Chemistry

ChEMBLi CHEMBL1795081.
GuidetoPHARMACOLOGYi 491.

PTM databases

PhosphoSitei Q61143.

Proteomic databases

PaxDbi Q61143.
PRIDEi Q61143.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000050433 ; ENSMUSP00000057965 ; ENSMUSG00000031997 .
GeneIDi 22068.
KEGGi mmu:22068.
UCSCi uc009odl.1. mouse.

Organism-specific databases

CTDi 7225.
MGIi MGI:109523. Trpc6.

Phylogenomic databases

eggNOGi NOG254238.
GeneTreei ENSGT00760000119180.
HOGENOMi HOG000020590.
HOVERGENi HBG068337.
InParanoidi Q61143.
KOi K04969.
OMAi NRGPAYM.
OrthoDBi EOG77HDD1.
TreeFami TF313147.

Enzyme and pathway databases

Reactomei REACT_219232. Effects of PIP2 hydrolysis.
REACT_227667. Elevation of cytosolic Ca2+ levels.
REACT_227861. TRP channels.

Miscellaneous databases

NextBioi 301892.
PROi Q61143.
SOURCEi Search...

Gene expression databases

Bgeei Q61143.
Genevestigatori Q61143.

Family and domain databases

Gene3Di 1.25.40.20. 1 hit.
InterProi IPR002110. Ankyrin_rpt.
IPR020683. Ankyrin_rpt-contain_dom.
IPR005821. Ion_trans_dom.
IPR004729. TRP_channel.
IPR013555. TRP_dom.
IPR005462. TRPC6_channel.
IPR002153. TRPC_channel.
[Graphical view ]
PANTHERi PTHR10117. PTHR10117. 1 hit.
PTHR10117:SF7. PTHR10117:SF7. 1 hit.
Pfami PF12796. Ank_2. 1 hit.
PF00520. Ion_trans. 1 hit.
PF08344. TRP_2. 1 hit.
[Graphical view ]
PRINTSi PR01097. TRNSRECEPTRP.
PR01647. TRPCHANNEL6.
SMARTi SM00248. ANK. 3 hits.
[Graphical view ]
SUPFAMi SSF48403. SSF48403. 1 hit.
TIGRFAMsi TIGR00870. trp. 1 hit.
PROSITEi PS50297. ANK_REP_REGION. 2 hits.
PS50088. ANK_REPEAT. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning and expression of a novel mammalian homolog of Drosophila transient receptor potential (Trp) involved in calcium entry secondary to activation of receptors coupled by the Gq class of G protein."
    Boulay G., Zhu X., Peyton M., Jiang M., Hurst R., Stefani E., Birnbaumer L.
    J. Biol. Chem. 272:29672-29680(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Brain.
  2. "Search for oncogenic regulators in an autocrine tumor model using differential display PCR: identification of novel candidate genes including the calcium channel mtrp6."
    Buess M., Engler O., Hirsch H.H., Moroni C.
    Oncogene 18:1487-1494(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: DBA/2.
  3. Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
    Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Embryo.
  5. "trp, a novel mammalian gene family essential for agonist-activated capacitative Ca2+ entry."
    Zhu X., Jiang M., Peyton M., Boulay G., Hurst R., Stefani E., Birnbaumer L.
    Cell 85:661-671(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 631-739.
    Tissue: Brain.
  6. Cited for: PHOSPHORYLATION BY FYN.

Entry informationi

Entry nameiTRPC6_MOUSE
AccessioniPrimary (citable) accession number: Q61143
Secondary accession number(s): B9EIW2, Q9Z2J1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: July 27, 2011
Last modified: October 29, 2014
This is version 132 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3