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Q61140

- BCAR1_MOUSE

UniProt

Q61140 - BCAR1_MOUSE

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Protein
Breast cancer anti-estrogen resistance protein 1
Gene
Bcar1, Cas, Crkas
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Docking protein which plays a central coordinating role for tyrosine kinase-based signaling related to cell adhesion. Implicated in induction of cell migration By similarity. Has been shown to be essential in cardiovascular development during embryogenesis.

GO - Molecular functioni

  1. protein binding Source: UniProtKB
  2. signal transducer activity Source: InterPro

GO - Biological processi

  1. B cell receptor signaling pathway Source: UniProtKB
  2. G-protein coupled receptor signaling pathway Source: UniProtKB
  3. actin filament organization Source: UniProtKB
  4. antigen receptor-mediated signaling pathway Source: UniProtKB
  5. cell adhesion Source: UniProtKB-KW
  6. cell chemotaxis Source: Ensembl
  7. cell migration Source: UniProtKB
  8. cellular response to hepatocyte growth factor stimulus Source: Ensembl
  9. epidermal growth factor receptor signaling pathway Source: UniProtKB
  10. hepatocyte growth factor receptor signaling pathway Source: Ensembl
  11. insulin receptor signaling pathway Source: UniProtKB
  12. integrin-mediated signaling pathway Source: UniProtKB
  13. neurotrophin TRK receptor signaling pathway Source: UniProtKB
  14. platelet-derived growth factor receptor signaling pathway Source: UniProtKB
  15. positive regulation of cell migration Source: UniProtKB
  16. positive regulation of endothelial cell migration Source: Ensembl
  17. vascular endothelial growth factor receptor signaling pathway Source: Ensembl
Complete GO annotation...

Keywords - Biological processi

Cell adhesion

Names & Taxonomyi

Protein namesi
Recommended name:
Breast cancer anti-estrogen resistance protein 1
Alternative name(s):
CRK-associated substrate
p130cas
Gene namesi
Name:Bcar1
Synonyms:Cas, Crkas
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 8

Organism-specific databases

MGIiMGI:108091. Bcar1.

Subcellular locationi

Cell junctionfocal adhesion By similarity. Cytoplasm By similarity
Note: Unphosphorylated form localizes in the cytoplasm and can move to the membrane upon tyrosine phosphorylation By similarity.

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB
  2. focal adhesion Source: UniProtKB
  3. lamellipodium Source: MGI
  4. plasma membrane Source: Ensembl
  5. ruffle Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cell junction, Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 874874Breast cancer anti-estrogen resistance protein 1
PRO_0000064855Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei1 – 11N-acetylmethionine By similarity
Modified residuei132 – 1321Phosphotyrosine1 Publication
Modified residuei143 – 1431Phosphoserine By similarity
Modified residuei253 – 2531Phosphotyrosine; by ABL1 By similarity
Modified residuei273 – 2731Phosphothreonine By similarity
Modified residuei296 – 2961Phosphoserine By similarity
Modified residuei366 – 3661Phosphotyrosine1 Publication
Modified residuei376 – 3761Phosphotyrosine1 Publication
Modified residuei414 – 4141Phosphotyrosine1 Publication
Modified residuei432 – 4321Phosphoserine By similarity
Modified residuei441 – 4411Phosphoserine By similarity
Modified residuei643 – 6431Phosphoserine By similarity

Post-translational modificationi

PTK2/FAK1 activation mediates phosphorylation at the YDYVHL motif; phosphorylation is most likely catalyzed by SRC family members. SRC-family kinases are recruited to the phosphorylated sites and can phosphorylate other tyrosine residues. Tyrosine phosphorylation is triggered by integrin mediated adhesion of cells to the extracellular matrix By similarity.
Dephosphorylated by PTPN14 at Tyr-132 By similarity.

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

MaxQBiQ61140.
PaxDbiQ61140.
PRIDEiQ61140.

PTM databases

PhosphoSiteiQ61140.

Expressioni

Gene expression databases

BgeeiQ61140.
CleanExiMM_BCAR1.
GenevestigatoriQ61140.

Interactioni

Subunit structurei

Forms complexes in vivo with PTK2/FAK1, adapter protein CRKL and LYN kinase. Can heterodimerize with NEDD9. Interacts with activated CSPG4. Interacts with BMX, INPPL1/SHIP2 and PEAK1 By similarity. Part of a collagen stimulated complex involved in cell migration composed of CDC42, CRK, TNK2 and BCAR1/p130cas By similarity. Interacts with BCAR3, the interaction regulates adhesion-dependent serine phosphorylation. Interacts with NPHP1, PTK2B/PYK2 and SH2D3C.6 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
Nphp1Q9QY532EBI-77088,EBI-77230
Ptk2P341523EBI-77088,EBI-77070
PTPN1P180315EBI-77088,EBI-968788From a different organism.
Srcin1Q9QWI62EBI-77088,EBI-775592

Protein-protein interaction databases

BioGridi198886. 6 interactions.
IntActiQ61140. 14 interactions.
MINTiMINT-100691.

Structurei

3D structure databases

ProteinModelPortaliQ61140.
SMRiQ61140. Positions 5-71, 454-614, 743-874.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini6 – 2621SH3
Add
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni119 – 420302Substrate for kinases By similarity
Add
BLAST
Regioni750 – 80051Divergent helix-loop-helix motif
Add
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi639 – 6479SH3-binding Reviewed prediction

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi74 – 8714Pro-rich
Add
BLAST
Compositional biasi426 – 618193Ser-rich
Add
BLAST

Domaini

Contains a central domain (substrate domain) containing multiple potential SH2-binding sites and a C-terminal domain containing a divergent helix-loop-helix (HLH) motif. The SH2-binding sites putatively bind CRK, NCK and ABL SH2 domains. The HLH motif is absolutely required for the induction of pseudohyphal growth in yeast and mediates heterodimerization with NEDD9.
A serine-rich region promotes activation of the serum response element (SRE) By similarity.
The SH3 domain is necessary for the localization of the protein to focal adhesions and interacts with one proline-rich region of PTK2/FAK1.

Sequence similaritiesi

Belongs to the CAS family.
Contains 1 SH3 domain.

Keywords - Domaini

SH3 domain, SH3-binding

Phylogenomic databases

eggNOGiNOG82196.
GeneTreeiENSGT00490000043324.
HOGENOMiHOG000261698.
HOVERGENiHBG004354.
KOiK05726.
OMAiFAKAKPF.
OrthoDBiEOG7QRQTD.
TreeFamiTF328782.

Family and domain databases

InterProiIPR028848. BCAR1.
IPR021901. CAS_DUF3513.
IPR014928. Serine_rich.
IPR001452. SH3_domain.
IPR013315. Spectrin_alpha_SH3.
[Graphical view]
PANTHERiPTHR10654:SF5. PTHR10654:SF5. 1 hit.
PfamiPF12026. DUF3513. 1 hit.
PF08824. Serine_rich. 1 hit.
PF00018. SH3_1. 1 hit.
[Graphical view]
PRINTSiPR00452. SH3DOMAIN.
PR01887. SPECTRNALPHA.
SMARTiSM00326. SH3. 1 hit.
[Graphical view]
SUPFAMiSSF50044. SSF50044. 1 hit.
PROSITEiPS50002. SH3. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform Cas-B (identifier: Q61140-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MTVPNVLAKA LYDNVAESPD ELSFRKGDIM TVLERDTQGL DGWWLCSLHG    50
RQGIVPGNRL KILVGMYDKK PVGPGPGPPA TPPQPQPSLP QGVHAPVPPA 100
SQYSPMLPTA YQPQSDNVYL VPTPSKTQQG LYQAPGPNPQ FQSPPAKQTS 150
TFSKQTPHHS FPSPATDLYQ VPPGPGSPAQ DIYQVPPSAG IGHDIYQVPP 200
SLDTRGWEGT KPPAKVVVPT RVGQGYVYEA AQTEQDEYDT PRHLLAPGPQ 250
DIYDVPPVRG LLPNQYGQEV YDTPPMAVKG PNGRDPLLDV YDVPPSVEKG 300
LLSSSHHSVY DVPPSVSKDV PDGPLLREET YDVPPAFAKP KPFDPTRHPL 350
ILAAPPPDSP AAEDVYDVPP PAPDLYDVPP GLRRPGPGTL YDVPRERVLP 400
PEVADGSVVD DGVYAVPPPA EREAPTDGKR LSASSTGSTR SSQSASSLEV 450
VVPGREPLEL EVAVESLARL QQGVSTTVAH LLDLVGSASG PGGWRGTSEP 500
QEPPAQDLKA AVAAVHGAVH ELLEFARGAV SNATHTSDRT LHAKLSRQLQ 550
KMEDVYQTLV VHGQVLDSGR GSPGFTPEDL DRLVACSRAV PEDAKQLASF 600
LHGNASLLFR RTKAPGPGPE GSSSLHPNPT DKASSIQSRP LPSPPKFTSQ 650
DSPDGQYENS EGGWMEDYDY VHLQGKEEFE KTQKELLERG NIMRQGKGQL 700
ELQQLKQFER LEQEVSRPID HDLANWTPAQ PLVPGRTGGL GPSDRQLLLF 750
YLEQCEANLT TLTDAVDAFF TAVATNQPPK IFVAHSKFVI LSAHKLVFIG 800
DTLSRQAKAA DVRSQVTHYS NLLCDLLRGI VATTKAAALQ YPSPSAAQDM 850
VDRVKELGHS TQQFRRVLGQ LAAA 874
Length:874
Mass (Da):94,285
Last modified:July 27, 2011 - v2
Checksum:i81E56BC7AD87B095
GO
Isoform Cas-A (identifier: Q61140-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-4: MTVP → MKYL

Show »
Length:874
Mass (Da):94,392
Checksum:i25B8F5D1D61CC8B1
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 44MTVP → MKYL in isoform Cas-A.
VSP_004134

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti72 – 721V → A in AAA93381. 1 Publication
Sequence conflicti72 – 721V → A in AAA93248. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U48853 mRNA. Translation: AAA93381.1.
U28151 mRNA. Translation: AAA93248.1.
AK145863 mRNA. Translation: BAE26705.1.
BC057578 mRNA. Translation: AAH57578.1.
CCDSiCCDS52675.1. [Q61140-1]
RefSeqiNP_001185768.1. NM_001198839.1. [Q61140-2]
NP_034084.2. NM_009954.3. [Q61140-1]
UniGeneiMm.3758.

Genome annotation databases

EnsembliENSMUST00000166232; ENSMUSP00000129584; ENSMUSG00000031955. [Q61140-1]
GeneIDi12927.
KEGGimmu:12927.
UCSCiuc009nmt.2. mouse. [Q61140-2]
uc009nmu.2. mouse. [Q61140-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U48853 mRNA. Translation: AAA93381.1 .
U28151 mRNA. Translation: AAA93248.1 .
AK145863 mRNA. Translation: BAE26705.1 .
BC057578 mRNA. Translation: AAH57578.1 .
CCDSi CCDS52675.1. [Q61140-1 ]
RefSeqi NP_001185768.1. NM_001198839.1. [Q61140-2 ]
NP_034084.2. NM_009954.3. [Q61140-1 ]
UniGenei Mm.3758.

3D structure databases

ProteinModelPortali Q61140.
SMRi Q61140. Positions 5-71, 454-614, 743-874.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 198886. 6 interactions.
IntActi Q61140. 14 interactions.
MINTi MINT-100691.

PTM databases

PhosphoSitei Q61140.

Proteomic databases

MaxQBi Q61140.
PaxDbi Q61140.
PRIDEi Q61140.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000166232 ; ENSMUSP00000129584 ; ENSMUSG00000031955 . [Q61140-1 ]
GeneIDi 12927.
KEGGi mmu:12927.
UCSCi uc009nmt.2. mouse. [Q61140-2 ]
uc009nmu.2. mouse. [Q61140-1 ]

Organism-specific databases

CTDi 9564.
MGIi MGI:108091. Bcar1.

Phylogenomic databases

eggNOGi NOG82196.
GeneTreei ENSGT00490000043324.
HOGENOMi HOG000261698.
HOVERGENi HBG004354.
KOi K05726.
OMAi FAKAKPF.
OrthoDBi EOG7QRQTD.
TreeFami TF328782.

Miscellaneous databases

NextBioi 282588.
PROi Q61140.
SOURCEi Search...

Gene expression databases

Bgeei Q61140.
CleanExi MM_BCAR1.
Genevestigatori Q61140.

Family and domain databases

InterProi IPR028848. BCAR1.
IPR021901. CAS_DUF3513.
IPR014928. Serine_rich.
IPR001452. SH3_domain.
IPR013315. Spectrin_alpha_SH3.
[Graphical view ]
PANTHERi PTHR10654:SF5. PTHR10654:SF5. 1 hit.
Pfami PF12026. DUF3513. 1 hit.
PF08824. Serine_rich. 1 hit.
PF00018. SH3_1. 1 hit.
[Graphical view ]
PRINTSi PR00452. SH3DOMAIN.
PR01887. SPECTRNALPHA.
SMARTi SM00326. SH3. 1 hit.
[Graphical view ]
SUPFAMi SSF50044. SSF50044. 1 hit.
PROSITEi PS50002. SH3. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Interaction between focal adhesion kinase and Crk-associated tyrosine kinase substrate p130Cas."
    Polte T.R., Hanks S.K.
    Proc. Natl. Acad. Sci. U.S.A. 92:10678-10682(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS CAS-A AND CAS-B), INTERACTION WITH PTK2/FAK1.
    Tissue: Embryo.
  2. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Placenta.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6.
  4. "AND-34, a novel p130Cas-binding thymic stromal cell protein regulated by adhesion and inflammatory cytokines."
    Cai D., Clayton L.K., Smolyar A., Lerner A.
    J. Immunol. 163:2104-2112(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH BCAR3.
  5. "Crk-associated substrate p130(Cas) interacts with nephrocystin and both proteins localize to cell-cell contacts of polarized epithelial cells."
    Donaldson J.C., Dempsey P.J., Reddy S., Bouton A.H., Coffey R.J., Hanks S.K.
    Exp. Cell Res. 256:168-178(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH NPHP1.
  6. "p130Cas regulates the activity of AND-34, a novel Ral, Rap1, and R-Ras guanine nucleotide exchange factor."
    Gotoh T., Cai D., Tian X., Feig L.A., Lerner A.
    J. Biol. Chem. 275:30118-30123(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH BCAR3.
  7. "Chat, a Cas/HEF1-associated adaptor protein that integrates multiple signaling pathways."
    Sakakibara A., Hattori S.
    J. Biol. Chem. 275:6404-6410(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH SH2D3C.
  8. "A novel hematopoietic adaptor protein, Chat-H, positively regulates T cell receptor-mediated interleukin-2 production by Jurkat cells."
    Sakakibara A., Hattori S., Nakamura S., Katagiri T.
    J. Biol. Chem. 278:6012-6017(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH SH2D3C.
    Tissue: Spleen.
  9. "Immunoaffinity profiling of tyrosine phosphorylation in cancer cells."
    Rush J., Moritz A., Lee K.A., Guo A., Goss V.L., Spek E.J., Zhang H., Zha X.-M., Polakiewicz R.D., Comb M.J.
    Nat. Biotechnol. 23:94-101(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-132; TYR-366; TYR-376 AND TYR-414, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  10. "Large-scale identification and evolution indexing of tyrosine phosphorylation sites from murine brain."
    Ballif B.A., Carey G.R., Sunyaev S.R., Gygi S.P.
    J. Proteome Res. 7:311-318(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Brain.
  11. "Large scale localization of protein phosphorylation by use of electron capture dissociation mass spectrometry."
    Sweet S.M., Bailey C.M., Cunningham D.L., Heath J.K., Cooper H.J.
    Mol. Cell. Proteomics 8:904-912(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-253, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Embryonic fibroblast.

Entry informationi

Entry nameiBCAR1_MOUSE
AccessioniPrimary (citable) accession number: Q61140
Secondary accession number(s): Q60869, Q6PFF9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: July 27, 2011
Last modified: July 9, 2014
This is version 135 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi