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Protein

Proprotein convertase subtilisin/kexin type 7

Gene

Pcsk7

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Serine endoprotease that processes various proproteins by cleavage at paired basic amino acids, recognizing the RXXX[KR]R consensus motif. Likely functions in the constitutive secretory pathway.

Cofactori

Ca2+By similarity

Enzyme regulationi

Inhibited by zinc and copper.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei186Charge relay systemBy similarity1
Active sitei227Charge relay systemBy similarity1
Active sitei405Charge relay systemBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase, Protease, Serine protease

Protein family/group databases

MEROPSiS08.077

Names & Taxonomyi

Protein namesi
Recommended name:
Proprotein convertase subtilisin/kexin type 7 (EC:3.4.21.-)
Alternative name(s):
Prohormone convertase 7
Proprotein convertase 7
Short name:
PC7
Subtilisin-like proprotein convertase 7
Short name:
SPC7
Subtilisin/kexin-like protease PC7
Gene namesi
Name:Pcsk7
Synonyms:Pc7
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 9

Organism-specific databases

MGIiMGI:107421 Pcsk7

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini141 – 666ExtracellularSequence analysisAdd BLAST526
Transmembranei667 – 687HelicalSequence analysisAdd BLAST21
Topological domaini688 – 770CytoplasmicSequence analysisAdd BLAST83

Keywords - Cellular componenti

Golgi apparatus, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 36By similarityAdd BLAST36
PropeptideiPRO_000002711637 – 140By similarityAdd BLAST104
ChainiPRO_0000027117141 – 770Proprotein convertase subtilisin/kexin type 7Add BLAST630

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi166N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi174N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi240N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi510N-linked (GlcNAc...) asparagineSequence analysis1

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei140 – 141Cleavage; by autolysisBy similarity2

Keywords - PTMi

Cleavage on pair of basic residues, Glycoprotein, Zymogen

Proteomic databases

PaxDbiQ61139
PRIDEiQ61139

PTM databases

iPTMnetiQ61139
PhosphoSitePlusiQ61139

Expressioni

Tissue specificityi

Widely expressed. Expressed in brain, lung, muscle, heart, liver, kidney, spleen and thymus.

Developmental stagei

Ubiquitously expressed at constitutive levels during embryogenesis.1 Publication

Gene expression databases

BgeeiENSMUSG00000035382
CleanExiMM_PCSK7
ExpressionAtlasiQ61139 baseline and differential
GenevisibleiQ61139 MM

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000047508

Structurei

3D structure databases

ProteinModelPortaliQ61139
SMRiQ61139
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini181 – 473Peptidase S8Add BLAST293
Domaini480 – 617P/Homo BPROSITE-ProRule annotationAdd BLAST138

Sequence similaritiesi

Belongs to the peptidase S8 family.Curated

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3525 Eukaryota
COG1404 LUCA
COG4935 LUCA
GeneTreeiENSGT00750000117358
HOGENOMiHOG000192536
HOVERGENiHBG008705
InParanoidiQ61139
KOiK08673
OMAiEVLWNVS
OrthoDBiEOG091G01XU
TreeFamiTF314277

Family and domain databases

CDDicd04059 Peptidases_S8_Protein_converta, 1 hit
Gene3Di2.60.120.260, 1 hit
3.30.70.850, 1 hit
3.40.50.200, 1 hit
InterProiView protein in InterPro
IPR008979 Galactose-bd-like_sf
IPR034182 Kexin/furin
IPR002884 P_dom
IPR000209 Peptidase_S8/S53_dom
IPR036852 Peptidase_S8/S53_dom_sf
IPR022398 Peptidase_S8_His-AS
IPR023828 Peptidase_S8_Ser-AS
IPR015500 Peptidase_S8_subtilisin-rel
IPR032815 S8_pro-domain
IPR038466 S8_pro-domain_sf
PfamiView protein in Pfam
PF01483 P_proprotein, 1 hit
PF00082 Peptidase_S8, 1 hit
PF16470 S8_pro-domain, 1 hit
PRINTSiPR00723 SUBTILISIN
SUPFAMiSSF49785 SSF49785, 1 hit
SSF52743 SSF52743, 1 hit
PROSITEiView protein in PROSITE
PS51829 P_HOMO_B, 1 hit
PS00137 SUBTILASE_HIS, 1 hit
PS00138 SUBTILASE_SER, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q61139-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPKGRQKVPH LDAHLGLPIC LWLELAIFFL VPQVMGLSEA GGLDILGTGG
60 70 80 90 100
LSWAVHLDSL EGERKEESLT QQADAVAQAA GLVNAGRIGE LQGHYLFVQP
110 120 130 140 150
TGHRQAMEVE AMRQQAEAVL ARHEAVRWHS EQTLLKRAKR SIHFNDPKYP
160 170 180 190 200
QQWHLNNRRS PGRDINVTGV WERNVTGRGV TVVVVDDGVE HTVQDIAPNY
210 220 230 240 250
SPEGSYDLNS NDPDPMPHPD EENGNHHGTR CAGEIAAVPN NSFCAVGVAY
260 270 280 290 300
GSRIAGIRVL DGPLTDSMEA VAFNKHYQIN DIYSCSWGPD DDGKTVDGPH
310 320 330 340 350
QLGKAALQHG VMAGRQGFGS IFVVASGNGG QHNDNCNYDG YANSIYTVTI
360 370 380 390 400
GAVDEEGRMP FYAEECASML AVTFSGGDKM LRSIVTTDWD LQKGTGCTEG
410 420 430 440 450
HTGTSAAAPL AAGMIALMLQ VRPCLTWRDV QHIIVFTAIQ YEDHHADWLT
460 470 480 490 500
NEAGFSHSHQ HGFGLLNAWR LVNAAKIWTS VPYLASYVSP MLKENKAVPR
510 520 530 540 550
SPHSLEVLWN VSRTDLEMSG LKTLEHVAVT VSITHPRRGS LELKLFCPSG
560 570 580 590 600
MMSLIGAPRS MDSDPNGFNA WTFSTVRCWG ERARGVYRLV IRDVGDEPLQ
610 620 630 640 650
MGILQQWQLT LYGSMWSPVD IKDRQSLLES AMSGKYLHDG FTLPCPPGLK
660 670 680 690 700
IPEEDGYTIT PNTLKTLVLV GCFSVFWTIY YMLEVCLSQR NKASTHGCRK
710 720 730 740 750
GCCPWAPRRQ NSKDAGTALE SMPLCSSKDL DGVDSEHGDC TTASSFLAPE
760 770
LDCPPHQPPD LLQGKSGQIC
Length:770
Mass (Da):84,358
Last modified:June 28, 2011 - v2
Checksum:iE612EB6B7A0E6BFA
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti191 – 193HTV → THR in AAB09725 (PubMed:8698813).Curated3

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U48830 mRNA Translation: AAB09725.1
AK148416 mRNA Translation: BAE28541.1
AK165389 mRNA Translation: BAE38156.1
CH466522 Genomic DNA Translation: EDL25666.1
BC006730 mRNA Translation: AAH06730.1
U75902 Genomic DNA Translation: AAB51126.1
CCDSiCCDS40609.1
RefSeqiNP_001268863.1, NM_001281934.1
NP_032820.2, NM_008794.2
XP_017168699.1, XM_017313210.1
UniGeneiMm.283283
Mm.3255

Genome annotation databases

EnsembliENSMUST00000039059; ENSMUSP00000047508; ENSMUSG00000035382
ENSMUST00000216672; ENSMUSP00000150393; ENSMUSG00000035382
GeneIDi18554
KEGGimmu:18554
UCSCiuc009pgp.1 mouse

Similar proteinsi

Entry informationi

Entry nameiPCSK7_MOUSE
AccessioniPrimary (citable) accession number: Q61139
Secondary accession number(s): O08577, Q922W4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 11, 2001
Last sequence update: June 28, 2011
Last modified: March 28, 2018
This is version 159 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health