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Q61139

- PCSK7_MOUSE

UniProt

Q61139 - PCSK7_MOUSE

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Protein

Proprotein convertase subtilisin/kexin type 7

Gene

Pcsk7

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli

Functioni

Likely to represent a ubiquitous endoprotease activity within constitutive secretory pathways and capable of cleavage at the RXXX[KR]R consensus motif.

Catalytic activityi

Release of mature proteins from their proproteins by cleavage of Arg-Xaa-Xaa-Xaa-Yaa-Arg-|-Zaa bonds, where Xaa can be any amino acid and Yaa is Arg or Lys.

Cofactori

Calcium.By similarity

Enzyme regulationi

Inhibited by zinc and copper.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei140 – 1412Cleavage; by autolysisBy similarity
Active sitei186 – 1861Charge relay systemBy similarity
Active sitei227 – 2271Charge relay systemBy similarity
Active sitei405 – 4051Charge relay systemBy similarity

GO - Molecular functioni

  1. peptidase activity Source: MGI
  2. serine-type endopeptidase activity Source: RefGenome

GO - Biological processi

  1. protein processing Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protease, Serine protease

Enzyme and pathway databases

ReactomeiREACT_206713. NGF processing.

Protein family/group databases

MEROPSiS08.077.

Names & Taxonomyi

Protein namesi
Recommended name:
Proprotein convertase subtilisin/kexin type 7 (EC:3.4.21.-)
Alternative name(s):
Prohormone convertase 7
Proprotein convertase 7
Short name:
PC7
Subtilisin-like proprotein convertase 7
Short name:
SPC7
Subtilisin/kexin-like protease PC7
Gene namesi
Name:Pcsk7
Synonyms:Pc7
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 9

Organism-specific databases

MGIiMGI:107421. Pcsk7.

Subcellular locationi

Golgi apparatustrans-Golgi network membrane By similarity; Single-pass type I membrane protein By similarity
Note: Seems to be localized intracellularly to the trans Golgi network.By similarity

GO - Cellular componenti

  1. endoplasmic reticulum lumen Source: Reactome
  2. Golgi apparatus Source: RefGenome
  3. integral component of Golgi membrane Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Golgi apparatus, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 3636By similarityAdd
BLAST
Propeptidei37 – 140104By similarityPRO_0000027116Add
BLAST
Chaini141 – 770630Proprotein convertase subtilisin/kexin type 7PRO_0000027117Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi166 – 1661N-linked (GlcNAc...)Sequence Analysis
Glycosylationi174 – 1741N-linked (GlcNAc...)Sequence Analysis
Glycosylationi240 – 2401N-linked (GlcNAc...)Sequence Analysis
Glycosylationi510 – 5101N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Cleavage on pair of basic residues, Glycoprotein, Zymogen

Proteomic databases

PRIDEiQ61139.

PTM databases

PhosphoSiteiQ61139.

Expressioni

Tissue specificityi

Widely expressed. Expressed in brain, lung, muscle, heart, liver, kidney, spleen and thymus.

Developmental stagei

Ubiquitously expressed at constitutive levels during embryogenesis.1 Publication

Gene expression databases

BgeeiQ61139.
CleanExiMM_PCSK7.
GenevestigatoriQ61139.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000047508.

Structurei

3D structure databases

ProteinModelPortaliQ61139.
SMRiQ61139. Positions 146-614.
ModBaseiSearch...
MobiDBiSearch...

Topological domain

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini141 – 666526ExtracellularSequence AnalysisAdd
BLAST
Topological domaini688 – 77083CytoplasmicSequence AnalysisAdd
BLAST

Transmembrane

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei667 – 68721HelicalSequence AnalysisAdd
BLAST

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini181 – 473293Peptidase S8Add
BLAST

Sequence similaritiesi

Belongs to the peptidase S8 family.Curated
Contains 1 peptidase S8 domain.Curated

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG4935.
GeneTreeiENSGT00750000117358.
HOGENOMiHOG000192536.
HOVERGENiHBG008705.
InParanoidiQ61139.
KOiK08673.
OMAiSGPCHWP.
OrthoDBiEOG73JKV3.
TreeFamiTF314277.

Family and domain databases

Gene3Di2.60.120.260. 1 hit.
3.40.50.200. 1 hit.
InterProiIPR008979. Galactose-bd-like.
IPR000209. Peptidase_S8/S53_dom.
IPR022398. Peptidase_S8_His-AS.
IPR023828. Peptidase_S8_Ser-AS.
IPR015500. Peptidase_S8_subtilisin-rel.
IPR009020. Prot_inh_propept.
IPR002884. PrprotnconvertsP.
[Graphical view]
PANTHERiPTHR10795. PTHR10795. 1 hit.
PfamiPF01483. P_proprotein. 1 hit.
PF00082. Peptidase_S8. 1 hit.
[Graphical view]
PRINTSiPR00723. SUBTILISIN.
SUPFAMiSSF49785. SSF49785. 1 hit.
SSF52743. SSF52743. 1 hit.
SSF54897. SSF54897. 1 hit.
PROSITEiPS00137. SUBTILASE_HIS. 1 hit.
PS00138. SUBTILASE_SER. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q61139-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MPKGRQKVPH LDAHLGLPIC LWLELAIFFL VPQVMGLSEA GGLDILGTGG
60 70 80 90 100
LSWAVHLDSL EGERKEESLT QQADAVAQAA GLVNAGRIGE LQGHYLFVQP
110 120 130 140 150
TGHRQAMEVE AMRQQAEAVL ARHEAVRWHS EQTLLKRAKR SIHFNDPKYP
160 170 180 190 200
QQWHLNNRRS PGRDINVTGV WERNVTGRGV TVVVVDDGVE HTVQDIAPNY
210 220 230 240 250
SPEGSYDLNS NDPDPMPHPD EENGNHHGTR CAGEIAAVPN NSFCAVGVAY
260 270 280 290 300
GSRIAGIRVL DGPLTDSMEA VAFNKHYQIN DIYSCSWGPD DDGKTVDGPH
310 320 330 340 350
QLGKAALQHG VMAGRQGFGS IFVVASGNGG QHNDNCNYDG YANSIYTVTI
360 370 380 390 400
GAVDEEGRMP FYAEECASML AVTFSGGDKM LRSIVTTDWD LQKGTGCTEG
410 420 430 440 450
HTGTSAAAPL AAGMIALMLQ VRPCLTWRDV QHIIVFTAIQ YEDHHADWLT
460 470 480 490 500
NEAGFSHSHQ HGFGLLNAWR LVNAAKIWTS VPYLASYVSP MLKENKAVPR
510 520 530 540 550
SPHSLEVLWN VSRTDLEMSG LKTLEHVAVT VSITHPRRGS LELKLFCPSG
560 570 580 590 600
MMSLIGAPRS MDSDPNGFNA WTFSTVRCWG ERARGVYRLV IRDVGDEPLQ
610 620 630 640 650
MGILQQWQLT LYGSMWSPVD IKDRQSLLES AMSGKYLHDG FTLPCPPGLK
660 670 680 690 700
IPEEDGYTIT PNTLKTLVLV GCFSVFWTIY YMLEVCLSQR NKASTHGCRK
710 720 730 740 750
GCCPWAPRRQ NSKDAGTALE SMPLCSSKDL DGVDSEHGDC TTASSFLAPE
760 770
LDCPPHQPPD LLQGKSGQIC
Length:770
Mass (Da):84,358
Last modified:June 28, 2011 - v2
Checksum:iE612EB6B7A0E6BFA
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti191 – 1933HTV → THR in AAB09725. (PubMed:8698813)Curated

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U48830 mRNA. Translation: AAB09725.1.
AK148416 mRNA. Translation: BAE28541.1.
AK165389 mRNA. Translation: BAE38156.1.
CH466522 Genomic DNA. Translation: EDL25666.1.
BC006730 mRNA. Translation: AAH06730.1.
U75902 Genomic DNA. Translation: AAB51126.1.
CCDSiCCDS40609.1.
RefSeqiNP_001268863.1. NM_001281934.1.
NP_032820.2. NM_008794.2.
UniGeneiMm.283283.
Mm.3255.

Genome annotation databases

EnsembliENSMUST00000039059; ENSMUSP00000047508; ENSMUSG00000035382.
GeneIDi18554.
KEGGimmu:18554.
UCSCiuc009pgp.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U48830 mRNA. Translation: AAB09725.1 .
AK148416 mRNA. Translation: BAE28541.1 .
AK165389 mRNA. Translation: BAE38156.1 .
CH466522 Genomic DNA. Translation: EDL25666.1 .
BC006730 mRNA. Translation: AAH06730.1 .
U75902 Genomic DNA. Translation: AAB51126.1 .
CCDSi CCDS40609.1.
RefSeqi NP_001268863.1. NM_001281934.1.
NP_032820.2. NM_008794.2.
UniGenei Mm.283283.
Mm.3255.

3D structure databases

ProteinModelPortali Q61139.
SMRi Q61139. Positions 146-614.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 10090.ENSMUSP00000047508.

Protein family/group databases

MEROPSi S08.077.

PTM databases

PhosphoSitei Q61139.

Proteomic databases

PRIDEi Q61139.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000039059 ; ENSMUSP00000047508 ; ENSMUSG00000035382 .
GeneIDi 18554.
KEGGi mmu:18554.
UCSCi uc009pgp.1. mouse.

Organism-specific databases

CTDi 9159.
MGIi MGI:107421. Pcsk7.

Phylogenomic databases

eggNOGi COG4935.
GeneTreei ENSGT00750000117358.
HOGENOMi HOG000192536.
HOVERGENi HBG008705.
InParanoidi Q61139.
KOi K08673.
OMAi SGPCHWP.
OrthoDBi EOG73JKV3.
TreeFami TF314277.

Enzyme and pathway databases

Reactomei REACT_206713. NGF processing.

Miscellaneous databases

NextBioi 294372.
PROi Q61139.
SOURCEi Search...

Gene expression databases

Bgeei Q61139.
CleanExi MM_PCSK7.
Genevestigatori Q61139.

Family and domain databases

Gene3Di 2.60.120.260. 1 hit.
3.40.50.200. 1 hit.
InterProi IPR008979. Galactose-bd-like.
IPR000209. Peptidase_S8/S53_dom.
IPR022398. Peptidase_S8_His-AS.
IPR023828. Peptidase_S8_Ser-AS.
IPR015500. Peptidase_S8_subtilisin-rel.
IPR009020. Prot_inh_propept.
IPR002884. PrprotnconvertsP.
[Graphical view ]
PANTHERi PTHR10795. PTHR10795. 1 hit.
Pfami PF01483. P_proprotein. 1 hit.
PF00082. Peptidase_S8. 1 hit.
[Graphical view ]
PRINTSi PR00723. SUBTILISIN.
SUPFAMi SSF49785. SSF49785. 1 hit.
SSF52743. SSF52743. 1 hit.
SSF54897. SSF54897. 1 hit.
PROSITEi PS00137. SUBTILASE_HIS. 1 hit.
PS00138. SUBTILASE_SER. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "SPC4, SPC6, and the novel protease SPC7 are coexpressed with bone morphogenetic proteins at distinct sites during embryogenesis."
    Constam D.B., Calfon M., Robertson E.J.
    J. Cell Biol. 134:181-191(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], DEVELOPMENTAL STAGE.
    Strain: C57BL/6.
    Tissue: Embryo.
  2. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Spleen.
  3. Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
    Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: FVB/N.
    Tissue: Mammary tumor.
  5. Ebihara M., Meerabux J., Young B.D.
    Submitted (OCT-1996) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-384.

Entry informationi

Entry nameiPCSK7_MOUSE
AccessioniPrimary (citable) accession number: Q61139
Secondary accession number(s): O08577, Q922W4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 11, 2001
Last sequence update: June 28, 2011
Last modified: October 29, 2014
This is version 131 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. Peptidase families
    Classification of peptidase families and list of entries
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3