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Q61139

- PCSK7_MOUSE

UniProt

Q61139 - PCSK7_MOUSE

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Protein
Proprotein convertase subtilisin/kexin type 7
Gene
Pcsk7, Pc7
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at transcript leveli

Functioni

Likely to represent a ubiquitous endoprotease activity within constitutive secretory pathways and capable of cleavage at the RXXX[KR]R consensus motif.

Catalytic activityi

Release of mature proteins from their proproteins by cleavage of Arg-Xaa-Xaa-Xaa-Yaa-Arg-|-Zaa bonds, where Xaa can be any amino acid and Yaa is Arg or Lys.

Cofactori

Calcium By similarity.

Enzyme regulationi

Inhibited by zinc and copper By similarity.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei140 – 1412Cleavage; by autolysis By similarity
Active sitei186 – 1861Charge relay system By similarity
Active sitei227 – 2271Charge relay system By similarity
Active sitei405 – 4051Charge relay system By similarity

GO - Molecular functioni

  1. peptidase activity Source: MGI
  2. serine-type endopeptidase activity Source: RefGenome

GO - Biological processi

  1. protein processing Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protease, Serine protease

Enzyme and pathway databases

ReactomeiREACT_206713. NGF processing.

Protein family/group databases

MEROPSiS08.077.

Names & Taxonomyi

Protein namesi
Recommended name:
Proprotein convertase subtilisin/kexin type 7 (EC:3.4.21.-)
Alternative name(s):
Prohormone convertase 7
Proprotein convertase 7
Short name:
PC7
Subtilisin-like proprotein convertase 7
Short name:
SPC7
Subtilisin/kexin-like protease PC7
Gene namesi
Name:Pcsk7
Synonyms:Pc7
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 9

Organism-specific databases

MGIiMGI:107421. Pcsk7.

Subcellular locationi

Golgi apparatustrans-Golgi network membrane; Single-pass type I membrane protein By similarity
Note: Seems to be localized intracellularly to the trans Golgi network By similarity.

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini141 – 666526Extracellular Reviewed prediction
Add
BLAST
Transmembranei667 – 68721Helical; Reviewed prediction
Add
BLAST
Topological domaini688 – 77083Cytoplasmic Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. Golgi apparatus Source: RefGenome
  2. endoplasmic reticulum lumen Source: Reactome
  3. integral component of Golgi membrane Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Golgi apparatus, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 3636 By similarity
Add
BLAST
Propeptidei37 – 140104 By similarity
PRO_0000027116Add
BLAST
Chaini141 – 770630Proprotein convertase subtilisin/kexin type 7
PRO_0000027117Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi166 – 1661N-linked (GlcNAc...) Reviewed prediction
Glycosylationi174 – 1741N-linked (GlcNAc...) Reviewed prediction
Glycosylationi240 – 2401N-linked (GlcNAc...) Reviewed prediction
Glycosylationi510 – 5101N-linked (GlcNAc...) Reviewed prediction

Keywords - PTMi

Cleavage on pair of basic residues, Glycoprotein, Zymogen

Proteomic databases

PRIDEiQ61139.

PTM databases

PhosphoSiteiQ61139.

Expressioni

Tissue specificityi

Widely expressed. Expressed in brain, lung, muscle, heart, liver, kidney, spleen and thymus.

Developmental stagei

Ubiquitously expressed at constitutive levels during embryogenesis.1 Publication

Gene expression databases

BgeeiQ61139.
CleanExiMM_PCSK7.
GenevestigatoriQ61139.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000047508.

Structurei

3D structure databases

ProteinModelPortaliQ61139.
SMRiQ61139. Positions 146-614.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini480 – 616137Homo B/P
Add
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni141 – 472332Catalytic
Add
BLAST

Sequence similaritiesi

Belongs to the peptidase S8 family.
Contains 1 homo B/P domain.

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG4935.
GeneTreeiENSGT00750000117689.
HOGENOMiHOG000192536.
HOVERGENiHBG008705.
InParanoidiQ922W4.
KOiK08673.
OMAiSGPCHWP.
OrthoDBiEOG73JKV3.
TreeFamiTF314277.

Family and domain databases

Gene3Di2.60.120.260. 1 hit.
3.40.50.200. 1 hit.
InterProiIPR008979. Galactose-bd-like.
IPR000209. Peptidase_S8/S53_dom.
IPR022398. Peptidase_S8_His-AS.
IPR023828. Peptidase_S8_Ser-AS.
IPR015500. Peptidase_S8_subtilisin-rel.
IPR009020. Prot_inh_propept.
IPR002884. PrprotnconvertsP.
[Graphical view]
PANTHERiPTHR10795. PTHR10795. 1 hit.
PfamiPF01483. P_proprotein. 1 hit.
PF00082. Peptidase_S8. 1 hit.
[Graphical view]
PRINTSiPR00723. SUBTILISIN.
SUPFAMiSSF49785. SSF49785. 1 hit.
SSF52743. SSF52743. 1 hit.
SSF54897. SSF54897. 1 hit.
PROSITEiPS00137. SUBTILASE_HIS. 1 hit.
PS00138. SUBTILASE_SER. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q61139-1 [UniParc]FASTAAdd to Basket

« Hide

MPKGRQKVPH LDAHLGLPIC LWLELAIFFL VPQVMGLSEA GGLDILGTGG    50
LSWAVHLDSL EGERKEESLT QQADAVAQAA GLVNAGRIGE LQGHYLFVQP 100
TGHRQAMEVE AMRQQAEAVL ARHEAVRWHS EQTLLKRAKR SIHFNDPKYP 150
QQWHLNNRRS PGRDINVTGV WERNVTGRGV TVVVVDDGVE HTVQDIAPNY 200
SPEGSYDLNS NDPDPMPHPD EENGNHHGTR CAGEIAAVPN NSFCAVGVAY 250
GSRIAGIRVL DGPLTDSMEA VAFNKHYQIN DIYSCSWGPD DDGKTVDGPH 300
QLGKAALQHG VMAGRQGFGS IFVVASGNGG QHNDNCNYDG YANSIYTVTI 350
GAVDEEGRMP FYAEECASML AVTFSGGDKM LRSIVTTDWD LQKGTGCTEG 400
HTGTSAAAPL AAGMIALMLQ VRPCLTWRDV QHIIVFTAIQ YEDHHADWLT 450
NEAGFSHSHQ HGFGLLNAWR LVNAAKIWTS VPYLASYVSP MLKENKAVPR 500
SPHSLEVLWN VSRTDLEMSG LKTLEHVAVT VSITHPRRGS LELKLFCPSG 550
MMSLIGAPRS MDSDPNGFNA WTFSTVRCWG ERARGVYRLV IRDVGDEPLQ 600
MGILQQWQLT LYGSMWSPVD IKDRQSLLES AMSGKYLHDG FTLPCPPGLK 650
IPEEDGYTIT PNTLKTLVLV GCFSVFWTIY YMLEVCLSQR NKASTHGCRK 700
GCCPWAPRRQ NSKDAGTALE SMPLCSSKDL DGVDSEHGDC TTASSFLAPE 750
LDCPPHQPPD LLQGKSGQIC 770
Length:770
Mass (Da):84,358
Last modified:June 28, 2011 - v2
Checksum:iE612EB6B7A0E6BFA
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti191 – 1933HTV → THR in AAB09725. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U48830 mRNA. Translation: AAB09725.1.
AK148416 mRNA. Translation: BAE28541.1.
AK165389 mRNA. Translation: BAE38156.1.
CH466522 Genomic DNA. Translation: EDL25666.1.
BC006730 mRNA. Translation: AAH06730.1.
U75902 Genomic DNA. Translation: AAB51126.1.
CCDSiCCDS40609.1.
RefSeqiNP_001268863.1. NM_001281934.1.
NP_032820.2. NM_008794.2.
UniGeneiMm.283283.
Mm.3255.

Genome annotation databases

EnsembliENSMUST00000039059; ENSMUSP00000047508; ENSMUSG00000035382.
GeneIDi18554.
KEGGimmu:18554.
UCSCiuc009pgp.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U48830 mRNA. Translation: AAB09725.1 .
AK148416 mRNA. Translation: BAE28541.1 .
AK165389 mRNA. Translation: BAE38156.1 .
CH466522 Genomic DNA. Translation: EDL25666.1 .
BC006730 mRNA. Translation: AAH06730.1 .
U75902 Genomic DNA. Translation: AAB51126.1 .
CCDSi CCDS40609.1.
RefSeqi NP_001268863.1. NM_001281934.1.
NP_032820.2. NM_008794.2.
UniGenei Mm.283283.
Mm.3255.

3D structure databases

ProteinModelPortali Q61139.
SMRi Q61139. Positions 146-614.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 10090.ENSMUSP00000047508.

Protein family/group databases

MEROPSi S08.077.

PTM databases

PhosphoSitei Q61139.

Proteomic databases

PRIDEi Q61139.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000039059 ; ENSMUSP00000047508 ; ENSMUSG00000035382 .
GeneIDi 18554.
KEGGi mmu:18554.
UCSCi uc009pgp.1. mouse.

Organism-specific databases

CTDi 9159.
MGIi MGI:107421. Pcsk7.

Phylogenomic databases

eggNOGi COG4935.
GeneTreei ENSGT00750000117689.
HOGENOMi HOG000192536.
HOVERGENi HBG008705.
InParanoidi Q922W4.
KOi K08673.
OMAi SGPCHWP.
OrthoDBi EOG73JKV3.
TreeFami TF314277.

Enzyme and pathway databases

Reactomei REACT_206713. NGF processing.

Miscellaneous databases

NextBioi 294372.
PROi Q61139.
SOURCEi Search...

Gene expression databases

Bgeei Q61139.
CleanExi MM_PCSK7.
Genevestigatori Q61139.

Family and domain databases

Gene3Di 2.60.120.260. 1 hit.
3.40.50.200. 1 hit.
InterProi IPR008979. Galactose-bd-like.
IPR000209. Peptidase_S8/S53_dom.
IPR022398. Peptidase_S8_His-AS.
IPR023828. Peptidase_S8_Ser-AS.
IPR015500. Peptidase_S8_subtilisin-rel.
IPR009020. Prot_inh_propept.
IPR002884. PrprotnconvertsP.
[Graphical view ]
PANTHERi PTHR10795. PTHR10795. 1 hit.
Pfami PF01483. P_proprotein. 1 hit.
PF00082. Peptidase_S8. 1 hit.
[Graphical view ]
PRINTSi PR00723. SUBTILISIN.
SUPFAMi SSF49785. SSF49785. 1 hit.
SSF52743. SSF52743. 1 hit.
SSF54897. SSF54897. 1 hit.
PROSITEi PS00137. SUBTILASE_HIS. 1 hit.
PS00138. SUBTILASE_SER. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "SPC4, SPC6, and the novel protease SPC7 are coexpressed with bone morphogenetic proteins at distinct sites during embryogenesis."
    Constam D.B., Calfon M., Robertson E.J.
    J. Cell Biol. 134:181-191(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], DEVELOPMENTAL STAGE.
    Strain: C57BL/6.
    Tissue: Embryo.
  2. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Spleen.
  3. Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
    Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: FVB/N.
    Tissue: Mammary tumor.
  5. Ebihara M., Meerabux J., Young B.D.
    Submitted (OCT-1996) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-384.

Entry informationi

Entry nameiPCSK7_MOUSE
AccessioniPrimary (citable) accession number: Q61139
Secondary accession number(s): O08577, Q922W4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 11, 2001
Last sequence update: June 28, 2011
Last modified: September 3, 2014
This is version 129 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. Peptidase families
    Classification of peptidase families and list of entries
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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