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Q61133

- GSTT2_MOUSE

UniProt

Q61133 - GSTT2_MOUSE

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Protein

Glutathione S-transferase theta-2

Gene

Gstt2

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli

Functioni

Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles.

Catalytic activityi

RX + glutathione = HX + R-S-glutathione.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei40 – 401GlutathioneBy similarity

GO - Molecular functioni

  1. glutathione transferase activity Source: MGI

GO - Biological processi

  1. glutathione metabolic process Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

Transferase

Enzyme and pathway databases

ReactomeiREACT_215316. Glutathione conjugation.

Names & Taxonomyi

Protein namesi
Recommended name:
Glutathione S-transferase theta-2 (EC:2.5.1.18)
Alternative name(s):
GST class-theta-2
Gene namesi
Name:Gstt2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 10

Organism-specific databases

MGIiMGI:106188. Gstt2.

Subcellular locationi

GO - Cellular componenti

  1. cytosol Source: MGI
  2. nucleus Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11RemovedBy similarity
Chaini2 – 244243Glutathione S-transferase theta-2PRO_0000185941Add
BLAST

Proteomic databases

PaxDbiQ61133.
PRIDEiQ61133.

PTM databases

PhosphoSiteiQ61133.

Expressioni

Tissue specificityi

In liver, highest expression found in central vein limiting plate hepatocytes. Also expressed in interlobular bile duct epithelial cells. In lung, expressed in Clara cells and ciliated cells of the bronchiolar epithelium and in type II alveolar cells of the lung parenchyma.

Gene expression databases

CleanExiMM_GSTT2.
GenevestigatoriQ61133.

Interactioni

Subunit structurei

Homodimer.

Protein-protein interaction databases

IntActiQ61133. 2 interactions.
MINTiMINT-4120895.

Structurei

3D structure databases

ProteinModelPortaliQ61133.
SMRiQ61133. Positions 1-244.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini2 – 8281GST N-terminalAdd
BLAST
Domaini88 – 230143GST C-terminalAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni53 – 542Glutathione bindingBy similarity
Regioni66 – 672Glutathione bindingBy similarity

Sequence similaritiesi

Belongs to the GST superfamily. Theta family.Curated
Contains 1 GST C-terminal domain.Curated
Contains 1 GST N-terminal domain.Curated

Phylogenomic databases

eggNOGiCOG0625.
GeneTreeiENSGT00540000069741.
HOGENOMiHOG000125747.
HOVERGENiHBG051854.
InParanoidiQ61133.
KOiK00799.
OMAiGVPLWVQ.
OrthoDBiEOG7V1FRJ.
TreeFamiTF325759.

Family and domain databases

Gene3Di1.20.1050.10. 1 hit.
3.40.30.10. 1 hit.
InterProiIPR010987. Glutathione-S-Trfase_C-like.
IPR004045. Glutathione_S-Trfase_N.
IPR004046. GST_C.
IPR012336. Thioredoxin-like_fold.
[Graphical view]
PfamiPF00043. GST_C. 1 hit.
PF13417. GST_N_3. 1 hit.
[Graphical view]
SUPFAMiSSF47616. SSF47616. 1 hit.
SSF52833. SSF52833. 1 hit.
PROSITEiPS50405. GST_CTER. 1 hit.
PS50404. GST_NTER. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q61133-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MGLELYLDLL SQPSRAVYIF AKKNGIPFQT RTVDILKGQH MSEQFSQVNC
60 70 80 90 100
LNKVPVLKDG SFVLTESTAI LIYLSSKYQV ADHWYPADLQ ARAQVHEYLG
110 120 130 140 150
WHADNIRGTF GVLLWTKVLG PLIGVQVPQE KVERNRDRMV LVLQQLEDKF
160 170 180 190 200
LRDRAFLVGQ QVTLADLMSL EELMQPVALG YNLFEGRPQL TAWRERVEAF
210 220 230 240
LGAELCQEAH STILSILGQA AKKMLPVPPP EVHASMQLRI ARIP
Length:244
Mass (Da):27,634
Last modified:October 3, 2012 - v4
Checksum:i3F45D6E12DA3DF29
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti38 – 381Missing in AAB03533. (PubMed:8617493)Curated
Sequence conflicti67 – 671S → R in AAB03533. (PubMed:8617493)Curated
Sequence conflicti178 – 1781A → G in AAB03534. (PubMed:8617493)Curated
Sequence conflicti206 – 2061C → Y in AAB03534. (PubMed:8617493)Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U48419 Genomic DNA. Translation: AAB03533.1.
U48420 mRNA. Translation: AAB03534.1.
X98056 mRNA. Translation: CAA66666.1.
AK002392 mRNA. Translation: BAB22065.1.
AK158939 mRNA. Translation: BAE34734.1.
AC142499 Genomic DNA. No translation available.
CH466553 Genomic DNA. Translation: EDL31881.1.
BC012707 mRNA. Translation: AAH12707.1.
CCDSiCCDS48601.1.
PIRiS71879.
RefSeqiNP_034491.2. NM_010361.2.
XP_006513303.1. XM_006513240.1.
UniGeneiMm.24118.

Genome annotation databases

EnsembliENSMUST00000038257; ENSMUSP00000046324; ENSMUSG00000033318.
GeneIDi14872.
KEGGimmu:14872.
UCSCiuc011xgs.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U48419 Genomic DNA. Translation: AAB03533.1 .
U48420 mRNA. Translation: AAB03534.1 .
X98056 mRNA. Translation: CAA66666.1 .
AK002392 mRNA. Translation: BAB22065.1 .
AK158939 mRNA. Translation: BAE34734.1 .
AC142499 Genomic DNA. No translation available.
CH466553 Genomic DNA. Translation: EDL31881.1 .
BC012707 mRNA. Translation: AAH12707.1 .
CCDSi CCDS48601.1.
PIRi S71879.
RefSeqi NP_034491.2. NM_010361.2.
XP_006513303.1. XM_006513240.1.
UniGenei Mm.24118.

3D structure databases

ProteinModelPortali Q61133.
SMRi Q61133. Positions 1-244.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

IntActi Q61133. 2 interactions.
MINTi MINT-4120895.

PTM databases

PhosphoSitei Q61133.

Proteomic databases

PaxDbi Q61133.
PRIDEi Q61133.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000038257 ; ENSMUSP00000046324 ; ENSMUSG00000033318 .
GeneIDi 14872.
KEGGi mmu:14872.
UCSCi uc011xgs.1. mouse.

Organism-specific databases

CTDi 2953.
MGIi MGI:106188. Gstt2.

Phylogenomic databases

eggNOGi COG0625.
GeneTreei ENSGT00540000069741.
HOGENOMi HOG000125747.
HOVERGENi HBG051854.
InParanoidi Q61133.
KOi K00799.
OMAi GVPLWVQ.
OrthoDBi EOG7V1FRJ.
TreeFami TF325759.

Enzyme and pathway databases

Reactomei REACT_215316. Glutathione conjugation.

Miscellaneous databases

NextBioi 287141.
PROi Q61133.
SOURCEi Search...

Gene expression databases

CleanExi MM_GSTT2.
Genevestigatori Q61133.

Family and domain databases

Gene3Di 1.20.1050.10. 1 hit.
3.40.30.10. 1 hit.
InterProi IPR010987. Glutathione-S-Trfase_C-like.
IPR004045. Glutathione_S-Trfase_N.
IPR004046. GST_C.
IPR012336. Thioredoxin-like_fold.
[Graphical view ]
Pfami PF00043. GST_C. 1 hit.
PF13417. GST_N_3. 1 hit.
[Graphical view ]
SUPFAMi SSF47616. SSF47616. 1 hit.
SSF52833. SSF52833. 1 hit.
PROSITEi PS50405. GST_CTER. 1 hit.
PS50404. GST_NTER. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Characterization of a cDNA and gene encoding the mouse theta class glutathione transferase mGSTT2 and its localization to chromosome 10B5-C1."
    Whittington A.T., Webb G.C., Baker R.T., Board P.G.
    Genomics 33:105-111(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA].
    Strain: 129/Sv and C57BL/6 X CBA.
    Tissue: Liver.
  2. "The distribution of theta-class glutathione S-transferases in the liver and lung of mouse, rat and human."
    Mainwaring G.W., Williams S.M., Foster J.R., Tugwood J., Green T.
    Biochem. J. 318:297-303(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: C57BL/6 X C3H.
    Tissue: Liver and Lung.
  3. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Kidney and Visual cortex.
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  5. Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
    Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: Czech II.
    Tissue: Mammary tumor.

Entry informationi

Entry nameiGSTT2_MOUSE
AccessioniPrimary (citable) accession number: Q61133
Secondary accession number(s): Q61134, Q64472, Q91VB0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: October 3, 2012
Last modified: October 1, 2014
This is version 117 of the entry and version 4 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3