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Protein

B1 bradykinin receptor

Gene

Bdkrb1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

This is a receptor for bradykinin. Could be a factor in chronic pain and inflammation.

GO - Molecular functioni

  • bradykinin receptor activity Source: Ensembl
  • peptide binding Source: MGI

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

ReactomeiR-MMU-375276. Peptide ligand-binding receptors.
R-MMU-416476. G alpha (q) signalling events.
R-MMU-418594. G alpha (i) signalling events.

Names & Taxonomyi

Protein namesi
Recommended name:
B1 bradykinin receptor
Short name:
B1R
Short name:
BK-1 receptor
Gene namesi
Name:Bdkrb1
Synonyms:Bdkrb
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 12

Organism-specific databases

MGIiMGI:88144. Bdkrb1.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 41ExtracellularSequence analysisAdd BLAST41
Transmembranei42 – 62Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini63 – 80CytoplasmicSequence analysisAdd BLAST18
Transmembranei81 – 101Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini102 – 118ExtracellularSequence analysisAdd BLAST17
Transmembranei119 – 139Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini140 – 161CytoplasmicSequence analysisAdd BLAST22
Transmembranei162 – 182Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini183 – 214ExtracellularSequence analysisAdd BLAST32
Transmembranei215 – 235Helical; Name=5Sequence analysisAdd BLAST21
Topological domaini236 – 258CytoplasmicSequence analysisAdd BLAST23
Transmembranei259 – 279Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini280 – 302ExtracellularSequence analysisAdd BLAST23
Transmembranei303 – 323Helical; Name=7Sequence analysisAdd BLAST21
Topological domaini324 – 334CytoplasmicSequence analysisAdd BLAST11

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Chemistry databases

ChEMBLiCHEMBL1250407.
GuidetoPHARMACOLOGYi41.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000691841 – 334B1 bradykinin receptorAdd BLAST334

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi13N-linked (GlcNAc...)Sequence analysis1
Glycosylationi21N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi117 ↔ 196PROSITE-ProRule annotation
Glycosylationi192N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ61125.
PRIDEiQ61125.

PTM databases

PhosphoSitePlusiQ61125.

Expressioni

Tissue specificityi

Expressed in heart, liver and lung.

Inductioni

By lipopolysaccharide (LPS) in heart, liver and lung five hours after treatment.1 Publication

Gene expression databases

BgeeiENSMUSG00000041347.
CleanExiMM_BDKRB1.
ExpressionAtlasiQ61125. baseline and differential.
GenevisibleiQ61125. MM.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000045335.

Chemistry databases

BindingDBiQ61125.

Structurei

3D structure databases

ProteinModelPortaliQ61125.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family. Bradykinin receptor subfamily. BDKRB1 sub-subfamily.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3656. Eukaryota.
ENOG410XRW9. LUCA.
GeneTreeiENSGT00760000119055.
HOGENOMiHOG000010314.
HOVERGENiHBG103183.
InParanoidiQ61125.
KOiK03915.
OMAiFNCHILA.
OrthoDBiEOG091G0D52.
PhylomeDBiQ61125.
TreeFamiTF330024.

Family and domain databases

InterProiIPR001186. Brdyknn_1_rcpt.
IPR000496. Brdyknn_rcpt.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00425. BRADYKININR.
PR00993. BRADYKINNB1R.
PR00237. GPCRRHODOPSN.
PROSITEiPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q61125-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MASQASLKLQ PSNQSQQAPP NITSCEGAPE AWDLLCRVLP GFVITVCFFG
60 70 80 90 100
LLGNLLVLSF FLLPWRRWWQ QRRQRLTIAE IYLANLAASD LVFVLGLPFW
110 120 130 140 150
AENVGNRFNW PFGSDLCRVV SGVIKANLFI SIFLVVAISQ DRYRLLVYPM
160 170 180 190 200
TSWGNRRRRQ AQVTCLLIWV AGGLLSTPTF LLRSVKVVPD LNISACILLF
210 220 230 240 250
PHEAWHFVRM VELNVLGFLL PLAAILYFNF HILASLRGQK EASRTRCGGP
260 270 280 290 300
KDSKTMGLIL TLVASFLVCW APYHFFAFLD FLVQVRVIQD CFWKELTDLG
310 320 330
LQLANFFAFV NSCLNPLIYV FAGRLFKTRV LGTL
Length:334
Mass (Da):37,886
Last modified:November 1, 1996 - v1
Checksum:i77C806203AC5C6CC
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti216L → V in AAD00029 (Ref. 2) Curated1
Sequence conflicti260L → P (Ref. 2) Curated1
Sequence conflicti263 – 265VAS → SSL (Ref. 2) Curated3
Sequence conflicti331 – 334LGTL → WELYKRCTSLKNAVLPSRKE LFQLSCWN in AAD00029 (Ref. 2) Curated4

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U47281 Genomic DNA. Translation: AAA99778.1.
U44436 Genomic DNA. Translation: AAD00029.1.
CCDSiCCDS26155.1.
PIRiJC4681.
RefSeqiNP_031565.1. NM_007539.2.
UniGeneiMm.377078.

Genome annotation databases

EnsembliENSMUST00000041229; ENSMUSP00000045335; ENSMUSG00000041347.
ENSMUST00000182899; ENSMUSP00000138118; ENSMUSG00000041347.
GeneIDi12061.
KEGGimmu:12061.
UCSCiuc007oyn.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U47281 Genomic DNA. Translation: AAA99778.1.
U44436 Genomic DNA. Translation: AAD00029.1.
CCDSiCCDS26155.1.
PIRiJC4681.
RefSeqiNP_031565.1. NM_007539.2.
UniGeneiMm.377078.

3D structure databases

ProteinModelPortaliQ61125.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000045335.

Chemistry databases

BindingDBiQ61125.
ChEMBLiCHEMBL1250407.
GuidetoPHARMACOLOGYi41.

Protein family/group databases

GPCRDBiSearch...

PTM databases

PhosphoSitePlusiQ61125.

Proteomic databases

PaxDbiQ61125.
PRIDEiQ61125.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000041229; ENSMUSP00000045335; ENSMUSG00000041347.
ENSMUST00000182899; ENSMUSP00000138118; ENSMUSG00000041347.
GeneIDi12061.
KEGGimmu:12061.
UCSCiuc007oyn.1. mouse.

Organism-specific databases

CTDi623.
MGIiMGI:88144. Bdkrb1.

Phylogenomic databases

eggNOGiKOG3656. Eukaryota.
ENOG410XRW9. LUCA.
GeneTreeiENSGT00760000119055.
HOGENOMiHOG000010314.
HOVERGENiHBG103183.
InParanoidiQ61125.
KOiK03915.
OMAiFNCHILA.
OrthoDBiEOG091G0D52.
PhylomeDBiQ61125.
TreeFamiTF330024.

Enzyme and pathway databases

ReactomeiR-MMU-375276. Peptide ligand-binding receptors.
R-MMU-416476. G alpha (q) signalling events.
R-MMU-418594. G alpha (i) signalling events.

Miscellaneous databases

PROiQ61125.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000041347.
CleanExiMM_BDKRB1.
ExpressionAtlasiQ61125. baseline and differential.
GenevisibleiQ61125. MM.

Family and domain databases

InterProiIPR001186. Brdyknn_1_rcpt.
IPR000496. Brdyknn_rcpt.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00425. BRADYKININR.
PR00993. BRADYKINNB1R.
PR00237. GPCRRHODOPSN.
PROSITEiPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiBKRB1_MOUSE
AccessioniPrimary (citable) accession number: Q61125
Secondary accession number(s): Q9Z1F4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 27, 2001
Last sequence update: November 1, 1996
Last modified: November 2, 2016
This is version 132 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.