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Q61125 (BKRB1_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 116. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
B1 bradykinin receptor

Short name=B1R
Short name=BK-1 receptor
Gene names
Name:Bdkrb1
Synonyms:Bdkrb
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length334 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

This is a receptor for bradykinin. Could be a factor in chronic pain and inflammation.

Subcellular location

Cell membrane; Multi-pass membrane protein.

Tissue specificity

Expressed in heart, liver and lung.

Induction

By lipopolysaccharide (LPS) in heart, liver and lung five hours after treatment. Ref.1

Sequence similarities

Belongs to the G-protein coupled receptor 1 family. Bradykinin receptor subfamily. BDKRB1 sub-subfamily.

Ontologies

Keywords
   Cellular componentCell membrane
Membrane
   DomainTransmembrane
Transmembrane helix
   Molecular functionG-protein coupled receptor
Receptor
Transducer
   PTMDisulfide bond
Glycoprotein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processcell migration

Inferred from electronic annotation. Source: Ensembl

inflammatory response

Inferred from electronic annotation. Source: Ensembl

negative regulation of blood pressure

Inferred from electronic annotation. Source: Ensembl

negative regulation of cell growth

Inferred from electronic annotation. Source: Ensembl

negative regulation of protein phosphorylation

Inferred from electronic annotation. Source: Ensembl

positive regulation of leukocyte migration

Inferred from electronic annotation. Source: Ensembl

positive regulation of release of sequestered calcium ion into cytosol

Inferred from electronic annotation. Source: Ensembl

protein kinase C-activating G-protein coupled receptor signaling pathway

Inferred from electronic annotation. Source: Ensembl

response to lipopolysaccharide

Inferred from direct assay Ref.1. Source: MGI

response to mechanical stimulus

Inferred from electronic annotation. Source: InterPro

sensory perception of pain

Inferred from electronic annotation. Source: Ensembl

   Cellular_componentintegral component of membrane

Inferred from electronic annotation. Source: UniProtKB-KW

neuron projection

Inferred from electronic annotation. Source: Ensembl

plasma membrane

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionbradykinin receptor activity

Inferred from electronic annotation. Source: Ensembl

peptide binding

Inferred from direct assay Ref.1. Source: MGI

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 334334B1 bradykinin receptor
PRO_0000069184

Regions

Topological domain1 – 4141Extracellular Potential
Transmembrane42 – 6221Helical; Name=1; Potential
Topological domain63 – 8018Cytoplasmic Potential
Transmembrane81 – 10121Helical; Name=2; Potential
Topological domain102 – 11817Extracellular Potential
Transmembrane119 – 13921Helical; Name=3; Potential
Topological domain140 – 16122Cytoplasmic Potential
Transmembrane162 – 18221Helical; Name=4; Potential
Topological domain183 – 21432Extracellular Potential
Transmembrane215 – 23521Helical; Name=5; Potential
Topological domain236 – 25823Cytoplasmic Potential
Transmembrane259 – 27921Helical; Name=6; Potential
Topological domain280 – 30223Extracellular Potential
Transmembrane303 – 32321Helical; Name=7; Potential
Topological domain324 – 33411Cytoplasmic Potential

Amino acid modifications

Glycosylation131N-linked (GlcNAc...) Potential
Glycosylation211N-linked (GlcNAc...) Potential
Glycosylation1921N-linked (GlcNAc...) Potential
Disulfide bond117 ↔ 196 By similarity

Experimental info

Sequence conflict2161L → V in AAD00029. Ref.2
Sequence conflict2601L → P Ref.2
Sequence conflict263 – 2653VAS → SSL Ref.2
Sequence conflict331 – 3344LGTL → WELYKRCTSLKNAVLPSRKE LFQLSCWN in AAD00029. Ref.2

Sequences

Sequence LengthMass (Da)Tools
Q61125 [UniParc].

Last modified November 1, 1996. Version 1.
Checksum: 77C806203AC5C6CC

FASTA33437,886
        10         20         30         40         50         60 
MASQASLKLQ PSNQSQQAPP NITSCEGAPE AWDLLCRVLP GFVITVCFFG LLGNLLVLSF 

        70         80         90        100        110        120 
FLLPWRRWWQ QRRQRLTIAE IYLANLAASD LVFVLGLPFW AENVGNRFNW PFGSDLCRVV 

       130        140        150        160        170        180 
SGVIKANLFI SIFLVVAISQ DRYRLLVYPM TSWGNRRRRQ AQVTCLLIWV AGGLLSTPTF 

       190        200        210        220        230        240 
LLRSVKVVPD LNISACILLF PHEAWHFVRM VELNVLGFLL PLAAILYFNF HILASLRGQK 

       250        260        270        280        290        300 
EASRTRCGGP KDSKTMGLIL TLVASFLVCW APYHFFAFLD FLVQVRVIQD CFWKELTDLG 

       310        320        330 
LQLANFFAFV NSCLNPLIYV FAGRLFKTRV LGTL 

« Hide

References

[1]"Molecular cloning and functional characterization of a mouse bradykinin B1 receptor gene."
Pesquero J.B., Pesquero J.L., Oliveira S.M., Roscher A.A., Metzger R., Ganten D., Bader M.
Biochem. Biophys. Res. Commun. 220:219-225(1996) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], INDUCTION.
Strain: 129/SvJ.
[2]"Novel pharmacological selectivity of the cloned murine B1 bradykinin receptor."
Yanagawa T., Prado G.N., Paquet J.L., Bestian S., Cousins B., Navarro J.
Submitted (JAN-1996) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
U47281 Genomic DNA. Translation: AAA99778.1.
U44436 Genomic DNA. Translation: AAD00029.1.
PIRJC4681.
RefSeqNP_031565.1. NM_007539.2.
UniGeneMm.377078.

3D structure databases

ProteinModelPortalQ61125.
SMRQ61125. Positions 46-334.
ModBaseSearch...
MobiDBSearch...

Chemistry

BindingDBQ61125.
ChEMBLCHEMBL1250407.
GuidetoPHARMACOLOGY41.

Protein family/group databases

GPCRDBSearch...

Proteomic databases

PRIDEQ61125.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000041229; ENSMUSP00000045335; ENSMUSG00000041347.
ENSMUST00000182899; ENSMUSP00000138118; ENSMUSG00000041347.
GeneID12061.
KEGGmmu:12061.
UCSCuc007oyn.1. mouse.

Organism-specific databases

CTD623.
MGIMGI:88144. Bdkrb1.

Phylogenomic databases

eggNOGNOG327312.
GeneTreeENSGT00720000108671.
HOGENOMHOG000010314.
HOVERGENHBG103183.
InParanoidQ61125.
KOK03915.
OMAPYHFFAF.
OrthoDBEOG7K9K36.
PhylomeDBQ61125.
TreeFamTF330024.

Gene expression databases

ArrayExpressQ61125.
BgeeQ61125.
CleanExMM_BDKRB1.
GenevestigatorQ61125.

Family and domain databases

Gene3D1.20.1070.10. 1 hit.
InterProIPR001186. Brdyknn_1_rcpt.
IPR000496. Brdyknn_rcpt.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PfamPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSPR00425. BRADYKININR.
PR00993. BRADYKINNB1R.
PR00237. GPCRRHODOPSN.
PROSITEPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio280369.
PROQ61125.
SOURCESearch...

Entry information

Entry nameBKRB1_MOUSE
AccessionPrimary (citable) accession number: Q61125
Secondary accession number(s): Q9Z1F4
Entry history
Integrated into UniProtKB/Swiss-Prot: April 27, 2001
Last sequence update: November 1, 1996
Last modified: April 16, 2014
This is version 116 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

7-transmembrane G-linked receptors

List of 7-transmembrane G-linked receptor entries