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Q61125

- BKRB1_MOUSE

UniProt

Q61125 - BKRB1_MOUSE

Protein

B1 bradykinin receptor

Gene

Bdkrb1

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 119 (01 Oct 2014)
      Sequence version 1 (01 Nov 1996)
      Previous versions | rss
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    Functioni

    This is a receptor for bradykinin. Could be a factor in chronic pain and inflammation.

    GO - Molecular functioni

    1. bradykinin receptor activity Source: Ensembl
    2. peptide binding Source: MGI

    GO - Biological processi

    1. cell migration Source: Ensembl
    2. inflammatory response Source: Ensembl
    3. negative regulation of blood pressure Source: Ensembl
    4. negative regulation of cell growth Source: Ensembl
    5. negative regulation of protein phosphorylation Source: Ensembl
    6. positive regulation of leukocyte migration Source: Ensembl
    7. positive regulation of release of sequestered calcium ion into cytosol Source: Ensembl
    8. protein kinase C-activating G-protein coupled receptor signaling pathway Source: Ensembl
    9. response to lipopolysaccharide Source: MGI
    10. response to mechanical stimulus Source: InterPro
    11. sensory perception of pain Source: Ensembl

    Keywords - Molecular functioni

    G-protein coupled receptor, Receptor, Transducer

    Enzyme and pathway databases

    ReactomeiREACT_207651. G alpha (q) signalling events.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    B1 bradykinin receptor
    Short name:
    B1R
    Short name:
    BK-1 receptor
    Gene namesi
    Name:Bdkrb1
    Synonyms:Bdkrb
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 12

    Organism-specific databases

    MGIiMGI:88144. Bdkrb1.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. neuron projection Source: Ensembl
    3. plasma membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cell membrane, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 334334B1 bradykinin receptorPRO_0000069184Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi13 – 131N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi21 – 211N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi117 ↔ 196PROSITE-ProRule annotation
    Glycosylationi192 – 1921N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    PRIDEiQ61125.

    Expressioni

    Tissue specificityi

    Expressed in heart, liver and lung.

    Inductioni

    By lipopolysaccharide (LPS) in heart, liver and lung five hours after treatment.1 Publication

    Gene expression databases

    ArrayExpressiQ61125.
    BgeeiQ61125.
    CleanExiMM_BDKRB1.
    GenevestigatoriQ61125.

    Interactioni

    Structurei

    3D structure databases

    ProteinModelPortaliQ61125.
    SMRiQ61125. Positions 46-334.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 4141ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini63 – 8018CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini102 – 11817ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini140 – 16122CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini183 – 21432ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini236 – 25823CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini280 – 30223ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini324 – 33411CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei42 – 6221Helical; Name=1Sequence AnalysisAdd
    BLAST
    Transmembranei81 – 10121Helical; Name=2Sequence AnalysisAdd
    BLAST
    Transmembranei119 – 13921Helical; Name=3Sequence AnalysisAdd
    BLAST
    Transmembranei162 – 18221Helical; Name=4Sequence AnalysisAdd
    BLAST
    Transmembranei215 – 23521Helical; Name=5Sequence AnalysisAdd
    BLAST
    Transmembranei259 – 27921Helical; Name=6Sequence AnalysisAdd
    BLAST
    Transmembranei303 – 32321Helical; Name=7Sequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the G-protein coupled receptor 1 family. Bradykinin receptor subfamily. BDKRB1 sub-subfamily.PROSITE-ProRule annotation

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG327312.
    GeneTreeiENSGT00720000108671.
    HOGENOMiHOG000010314.
    HOVERGENiHBG103183.
    InParanoidiQ61125.
    KOiK03915.
    OMAiPYHFFAF.
    OrthoDBiEOG7K9K36.
    PhylomeDBiQ61125.
    TreeFamiTF330024.

    Family and domain databases

    Gene3Di1.20.1070.10. 1 hit.
    InterProiIPR001186. Brdyknn_1_rcpt.
    IPR000496. Brdyknn_rcpt.
    IPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    [Graphical view]
    PfamiPF00001. 7tm_1. 1 hit.
    [Graphical view]
    PRINTSiPR00425. BRADYKININR.
    PR00993. BRADYKINNB1R.
    PR00237. GPCRRHODOPSN.
    PROSITEiPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q61125-1 [UniParc]FASTAAdd to Basket

    « Hide

    MASQASLKLQ PSNQSQQAPP NITSCEGAPE AWDLLCRVLP GFVITVCFFG    50
    LLGNLLVLSF FLLPWRRWWQ QRRQRLTIAE IYLANLAASD LVFVLGLPFW 100
    AENVGNRFNW PFGSDLCRVV SGVIKANLFI SIFLVVAISQ DRYRLLVYPM 150
    TSWGNRRRRQ AQVTCLLIWV AGGLLSTPTF LLRSVKVVPD LNISACILLF 200
    PHEAWHFVRM VELNVLGFLL PLAAILYFNF HILASLRGQK EASRTRCGGP 250
    KDSKTMGLIL TLVASFLVCW APYHFFAFLD FLVQVRVIQD CFWKELTDLG 300
    LQLANFFAFV NSCLNPLIYV FAGRLFKTRV LGTL 334
    Length:334
    Mass (Da):37,886
    Last modified:November 1, 1996 - v1
    Checksum:i77C806203AC5C6CC
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti216 – 2161L → V in AAD00029. 1 PublicationCurated
    Sequence conflicti260 – 2601L → P1 PublicationCurated
    Sequence conflicti263 – 2653VAS → SSL1 PublicationCurated
    Sequence conflicti331 – 3344LGTL → WELYKRCTSLKNAVLPSRKE LFQLSCWN in AAD00029. 1 PublicationCurated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U47281 Genomic DNA. Translation: AAA99778.1.
    U44436 Genomic DNA. Translation: AAD00029.1.
    CCDSiCCDS26155.1.
    PIRiJC4681.
    RefSeqiNP_031565.1. NM_007539.2.
    UniGeneiMm.377078.

    Genome annotation databases

    EnsembliENSMUST00000041229; ENSMUSP00000045335; ENSMUSG00000041347.
    ENSMUST00000182899; ENSMUSP00000138118; ENSMUSG00000041347.
    GeneIDi12061.
    KEGGimmu:12061.
    UCSCiuc007oyn.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U47281 Genomic DNA. Translation: AAA99778.1 .
    U44436 Genomic DNA. Translation: AAD00029.1 .
    CCDSi CCDS26155.1.
    PIRi JC4681.
    RefSeqi NP_031565.1. NM_007539.2.
    UniGenei Mm.377078.

    3D structure databases

    ProteinModelPortali Q61125.
    SMRi Q61125. Positions 46-334.
    ModBasei Search...
    MobiDBi Search...

    Chemistry

    BindingDBi Q61125.
    ChEMBLi CHEMBL1250407.
    GuidetoPHARMACOLOGYi 41.

    Protein family/group databases

    GPCRDBi Search...

    Proteomic databases

    PRIDEi Q61125.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000041229 ; ENSMUSP00000045335 ; ENSMUSG00000041347 .
    ENSMUST00000182899 ; ENSMUSP00000138118 ; ENSMUSG00000041347 .
    GeneIDi 12061.
    KEGGi mmu:12061.
    UCSCi uc007oyn.1. mouse.

    Organism-specific databases

    CTDi 623.
    MGIi MGI:88144. Bdkrb1.

    Phylogenomic databases

    eggNOGi NOG327312.
    GeneTreei ENSGT00720000108671.
    HOGENOMi HOG000010314.
    HOVERGENi HBG103183.
    InParanoidi Q61125.
    KOi K03915.
    OMAi PYHFFAF.
    OrthoDBi EOG7K9K36.
    PhylomeDBi Q61125.
    TreeFami TF330024.

    Enzyme and pathway databases

    Reactomei REACT_207651. G alpha (q) signalling events.

    Miscellaneous databases

    NextBioi 280369.
    PROi Q61125.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q61125.
    Bgeei Q61125.
    CleanExi MM_BDKRB1.
    Genevestigatori Q61125.

    Family and domain databases

    Gene3Di 1.20.1070.10. 1 hit.
    InterProi IPR001186. Brdyknn_1_rcpt.
    IPR000496. Brdyknn_rcpt.
    IPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    [Graphical view ]
    Pfami PF00001. 7tm_1. 1 hit.
    [Graphical view ]
    PRINTSi PR00425. BRADYKININR.
    PR00993. BRADYKINNB1R.
    PR00237. GPCRRHODOPSN.
    PROSITEi PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Molecular cloning and functional characterization of a mouse bradykinin B1 receptor gene."
      Pesquero J.B., Pesquero J.L., Oliveira S.M., Roscher A.A., Metzger R., Ganten D., Bader M.
      Biochem. Biophys. Res. Commun. 220:219-225(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], INDUCTION.
      Strain: 129/SvJ.
    2. "Novel pharmacological selectivity of the cloned murine B1 bradykinin receptor."
      Yanagawa T., Prado G.N., Paquet J.L., Bestian S., Cousins B., Navarro J.
      Submitted (JAN-1996) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

    Entry informationi

    Entry nameiBKRB1_MOUSE
    AccessioniPrimary (citable) accession number: Q61125
    Secondary accession number(s): Q9Z1F4
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 27, 2001
    Last sequence update: November 1, 1996
    Last modified: October 1, 2014
    This is version 119 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. 7-transmembrane G-linked receptors
      List of 7-transmembrane G-linked receptor entries
    2. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3