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Q61125

- BKRB1_MOUSE

UniProt

Q61125 - BKRB1_MOUSE

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Protein

B1 bradykinin receptor

Gene

Bdkrb1

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli

Functioni

This is a receptor for bradykinin. Could be a factor in chronic pain and inflammation.

GO - Molecular functioni

  1. bradykinin receptor activity Source: Ensembl
  2. peptide binding Source: MGI

GO - Biological processi

  1. cell migration Source: Ensembl
  2. inflammatory response Source: Ensembl
  3. negative regulation of blood pressure Source: Ensembl
  4. negative regulation of cell growth Source: Ensembl
  5. negative regulation of protein phosphorylation Source: Ensembl
  6. positive regulation of leukocyte migration Source: Ensembl
  7. positive regulation of release of sequestered calcium ion into cytosol Source: Ensembl
  8. protein kinase C-activating G-protein coupled receptor signaling pathway Source: Ensembl
  9. response to lipopolysaccharide Source: MGI
  10. response to mechanical stimulus Source: InterPro
  11. sensory perception of pain Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

ReactomeiREACT_207651. G alpha (q) signalling events.

Names & Taxonomyi

Protein namesi
Recommended name:
B1 bradykinin receptor
Short name:
B1R
Short name:
BK-1 receptor
Gene namesi
Name:Bdkrb1
Synonyms:Bdkrb
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 12

Organism-specific databases

MGIiMGI:88144. Bdkrb1.

Subcellular locationi

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. neuron projection Source: Ensembl
  3. plasma membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 334334B1 bradykinin receptorPRO_0000069184Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi13 – 131N-linked (GlcNAc...)Sequence Analysis
Glycosylationi21 – 211N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi117 ↔ 196PROSITE-ProRule annotation
Glycosylationi192 – 1921N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PRIDEiQ61125.

Expressioni

Tissue specificityi

Expressed in heart, liver and lung.

Inductioni

By lipopolysaccharide (LPS) in heart, liver and lung five hours after treatment.1 Publication

Gene expression databases

BgeeiQ61125.
CleanExiMM_BDKRB1.
ExpressionAtlasiQ61125. baseline and differential.
GenevestigatoriQ61125.

Interactioni

Structurei

3D structure databases

ProteinModelPortaliQ61125.
SMRiQ61125. Positions 46-334.
ModBaseiSearch...
MobiDBiSearch...

Topological domain

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 4141ExtracellularSequence AnalysisAdd
BLAST
Topological domaini63 – 8018CytoplasmicSequence AnalysisAdd
BLAST
Topological domaini102 – 11817ExtracellularSequence AnalysisAdd
BLAST
Topological domaini140 – 16122CytoplasmicSequence AnalysisAdd
BLAST
Topological domaini183 – 21432ExtracellularSequence AnalysisAdd
BLAST
Topological domaini236 – 25823CytoplasmicSequence AnalysisAdd
BLAST
Topological domaini280 – 30223ExtracellularSequence AnalysisAdd
BLAST
Topological domaini324 – 33411CytoplasmicSequence AnalysisAdd
BLAST

Transmembrane

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei42 – 6221Helical; Name=1Sequence AnalysisAdd
BLAST
Transmembranei81 – 10121Helical; Name=2Sequence AnalysisAdd
BLAST
Transmembranei119 – 13921Helical; Name=3Sequence AnalysisAdd
BLAST
Transmembranei162 – 18221Helical; Name=4Sequence AnalysisAdd
BLAST
Transmembranei215 – 23521Helical; Name=5Sequence AnalysisAdd
BLAST
Transmembranei259 – 27921Helical; Name=6Sequence AnalysisAdd
BLAST
Transmembranei303 – 32321Helical; Name=7Sequence AnalysisAdd
BLAST

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family. Bradykinin receptor subfamily. BDKRB1 sub-subfamily.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG327312.
GeneTreeiENSGT00760000119055.
HOGENOMiHOG000010314.
HOVERGENiHBG103183.
InParanoidiQ61125.
KOiK03915.
OMAiPYHFFAF.
OrthoDBiEOG7K9K36.
PhylomeDBiQ61125.
TreeFamiTF330024.

Family and domain databases

Gene3Di1.20.1070.10. 1 hit.
InterProiIPR001186. Brdyknn_1_rcpt.
IPR000496. Brdyknn_rcpt.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00425. BRADYKININR.
PR00993. BRADYKINNB1R.
PR00237. GPCRRHODOPSN.
PROSITEiPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q61125-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MASQASLKLQ PSNQSQQAPP NITSCEGAPE AWDLLCRVLP GFVITVCFFG
60 70 80 90 100
LLGNLLVLSF FLLPWRRWWQ QRRQRLTIAE IYLANLAASD LVFVLGLPFW
110 120 130 140 150
AENVGNRFNW PFGSDLCRVV SGVIKANLFI SIFLVVAISQ DRYRLLVYPM
160 170 180 190 200
TSWGNRRRRQ AQVTCLLIWV AGGLLSTPTF LLRSVKVVPD LNISACILLF
210 220 230 240 250
PHEAWHFVRM VELNVLGFLL PLAAILYFNF HILASLRGQK EASRTRCGGP
260 270 280 290 300
KDSKTMGLIL TLVASFLVCW APYHFFAFLD FLVQVRVIQD CFWKELTDLG
310 320 330
LQLANFFAFV NSCLNPLIYV FAGRLFKTRV LGTL
Length:334
Mass (Da):37,886
Last modified:November 1, 1996 - v1
Checksum:i77C806203AC5C6CC
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti216 – 2161L → V in AAD00029. 1 PublicationCurated
Sequence conflicti260 – 2601L → P1 PublicationCurated
Sequence conflicti263 – 2653VAS → SSL1 PublicationCurated
Sequence conflicti331 – 3344LGTL → WELYKRCTSLKNAVLPSRKE LFQLSCWN in AAD00029. 1 PublicationCurated

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U47281 Genomic DNA. Translation: AAA99778.1.
U44436 Genomic DNA. Translation: AAD00029.1.
CCDSiCCDS26155.1.
PIRiJC4681.
RefSeqiNP_031565.1. NM_007539.2.
UniGeneiMm.377078.

Genome annotation databases

EnsembliENSMUST00000041229; ENSMUSP00000045335; ENSMUSG00000041347.
ENSMUST00000182899; ENSMUSP00000138118; ENSMUSG00000041347.
GeneIDi12061.
KEGGimmu:12061.
UCSCiuc007oyn.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U47281 Genomic DNA. Translation: AAA99778.1 .
U44436 Genomic DNA. Translation: AAD00029.1 .
CCDSi CCDS26155.1.
PIRi JC4681.
RefSeqi NP_031565.1. NM_007539.2.
UniGenei Mm.377078.

3D structure databases

ProteinModelPortali Q61125.
SMRi Q61125. Positions 46-334.
ModBasei Search...
MobiDBi Search...

Chemistry

BindingDBi Q61125.
ChEMBLi CHEMBL1250407.
GuidetoPHARMACOLOGYi 41.

Protein family/group databases

GPCRDBi Search...

Proteomic databases

PRIDEi Q61125.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000041229 ; ENSMUSP00000045335 ; ENSMUSG00000041347 .
ENSMUST00000182899 ; ENSMUSP00000138118 ; ENSMUSG00000041347 .
GeneIDi 12061.
KEGGi mmu:12061.
UCSCi uc007oyn.1. mouse.

Organism-specific databases

CTDi 623.
MGIi MGI:88144. Bdkrb1.

Phylogenomic databases

eggNOGi NOG327312.
GeneTreei ENSGT00760000119055.
HOGENOMi HOG000010314.
HOVERGENi HBG103183.
InParanoidi Q61125.
KOi K03915.
OMAi PYHFFAF.
OrthoDBi EOG7K9K36.
PhylomeDBi Q61125.
TreeFami TF330024.

Enzyme and pathway databases

Reactomei REACT_207651. G alpha (q) signalling events.

Miscellaneous databases

NextBioi 280369.
PROi Q61125.
SOURCEi Search...

Gene expression databases

Bgeei Q61125.
CleanExi MM_BDKRB1.
ExpressionAtlasi Q61125. baseline and differential.
Genevestigatori Q61125.

Family and domain databases

Gene3Di 1.20.1070.10. 1 hit.
InterProi IPR001186. Brdyknn_1_rcpt.
IPR000496. Brdyknn_rcpt.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view ]
Pfami PF00001. 7tm_1. 1 hit.
[Graphical view ]
PRINTSi PR00425. BRADYKININR.
PR00993. BRADYKINNB1R.
PR00237. GPCRRHODOPSN.
PROSITEi PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Molecular cloning and functional characterization of a mouse bradykinin B1 receptor gene."
    Pesquero J.B., Pesquero J.L., Oliveira S.M., Roscher A.A., Metzger R., Ganten D., Bader M.
    Biochem. Biophys. Res. Commun. 220:219-225(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], INDUCTION.
    Strain: 129/SvJ.
  2. "Novel pharmacological selectivity of the cloned murine B1 bradykinin receptor."
    Yanagawa T., Prado G.N., Paquet J.L., Bestian S., Cousins B., Navarro J.
    Submitted (JAN-1996) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

Entry informationi

Entry nameiBKRB1_MOUSE
AccessioniPrimary (citable) accession number: Q61125
Secondary accession number(s): Q9Z1F4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 27, 2001
Last sequence update: November 1, 1996
Last modified: October 29, 2014
This is version 120 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3