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Protein

B1 bradykinin receptor

Gene

Bdkrb1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

This is a receptor for bradykinin. Could be a factor in chronic pain and inflammation.

GO - Molecular functioni

  • bradykinin receptor activity Source: Ensembl
  • peptide binding Source: MGI

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

ReactomeiREACT_319210. Peptide ligand-binding receptors.
REACT_331048. G alpha (i) signalling events.
REACT_347934. G alpha (q) signalling events.

Names & Taxonomyi

Protein namesi
Recommended name:
B1 bradykinin receptor
Short name:
B1R
Short name:
BK-1 receptor
Gene namesi
Name:Bdkrb1
Synonyms:Bdkrb
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589 Componenti: Chromosome 12

Organism-specific databases

MGIiMGI:88144. Bdkrb1.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 4141ExtracellularSequence AnalysisAdd
BLAST
Transmembranei42 – 6221Helical; Name=1Sequence AnalysisAdd
BLAST
Topological domaini63 – 8018CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei81 – 10121Helical; Name=2Sequence AnalysisAdd
BLAST
Topological domaini102 – 11817ExtracellularSequence AnalysisAdd
BLAST
Transmembranei119 – 13921Helical; Name=3Sequence AnalysisAdd
BLAST
Topological domaini140 – 16122CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei162 – 18221Helical; Name=4Sequence AnalysisAdd
BLAST
Topological domaini183 – 21432ExtracellularSequence AnalysisAdd
BLAST
Transmembranei215 – 23521Helical; Name=5Sequence AnalysisAdd
BLAST
Topological domaini236 – 25823CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei259 – 27921Helical; Name=6Sequence AnalysisAdd
BLAST
Topological domaini280 – 30223ExtracellularSequence AnalysisAdd
BLAST
Transmembranei303 – 32321Helical; Name=7Sequence AnalysisAdd
BLAST
Topological domaini324 – 33411CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 334334B1 bradykinin receptorPRO_0000069184Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi13 – 131N-linked (GlcNAc...)Sequence Analysis
Glycosylationi21 – 211N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi117 ↔ 196PROSITE-ProRule annotation
Glycosylationi192 – 1921N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PRIDEiQ61125.

Expressioni

Tissue specificityi

Expressed in heart, liver and lung.

Inductioni

By lipopolysaccharide (LPS) in heart, liver and lung five hours after treatment.1 Publication

Gene expression databases

BgeeiQ61125.
CleanExiMM_BDKRB1.
ExpressionAtlasiQ61125. baseline and differential.
GenevestigatoriQ61125.

Interactioni

Structurei

3D structure databases

ProteinModelPortaliQ61125.
SMRiQ61125. Positions 46-334.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family. Bradykinin receptor subfamily. BDKRB1 sub-subfamily.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG327312.
GeneTreeiENSGT00760000119055.
HOGENOMiHOG000010314.
HOVERGENiHBG103183.
InParanoidiQ61125.
KOiK03915.
OMAiPYHFFAF.
OrthoDBiEOG7K9K36.
PhylomeDBiQ61125.
TreeFamiTF330024.

Family and domain databases

InterProiIPR001186. Brdyknn_1_rcpt.
IPR000496. Brdyknn_rcpt.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00425. BRADYKININR.
PR00993. BRADYKINNB1R.
PR00237. GPCRRHODOPSN.
PROSITEiPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q61125-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MASQASLKLQ PSNQSQQAPP NITSCEGAPE AWDLLCRVLP GFVITVCFFG
60 70 80 90 100
LLGNLLVLSF FLLPWRRWWQ QRRQRLTIAE IYLANLAASD LVFVLGLPFW
110 120 130 140 150
AENVGNRFNW PFGSDLCRVV SGVIKANLFI SIFLVVAISQ DRYRLLVYPM
160 170 180 190 200
TSWGNRRRRQ AQVTCLLIWV AGGLLSTPTF LLRSVKVVPD LNISACILLF
210 220 230 240 250
PHEAWHFVRM VELNVLGFLL PLAAILYFNF HILASLRGQK EASRTRCGGP
260 270 280 290 300
KDSKTMGLIL TLVASFLVCW APYHFFAFLD FLVQVRVIQD CFWKELTDLG
310 320 330
LQLANFFAFV NSCLNPLIYV FAGRLFKTRV LGTL
Length:334
Mass (Da):37,886
Last modified:November 1, 1996 - v1
Checksum:i77C806203AC5C6CC
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti216 – 2161L → V in AAD00029 (Ref. 2) Curated
Sequence conflicti260 – 2601L → P (Ref. 2) Curated
Sequence conflicti263 – 2653VAS → SSL (Ref. 2) Curated
Sequence conflicti331 – 3344LGTL → WELYKRCTSLKNAVLPSRKE LFQLSCWN in AAD00029 (Ref. 2) Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U47281 Genomic DNA. Translation: AAA99778.1.
U44436 Genomic DNA. Translation: AAD00029.1.
CCDSiCCDS26155.1.
PIRiJC4681.
RefSeqiNP_031565.1. NM_007539.2.
UniGeneiMm.377078.

Genome annotation databases

EnsembliENSMUST00000041229; ENSMUSP00000045335; ENSMUSG00000041347.
ENSMUST00000182899; ENSMUSP00000138118; ENSMUSG00000041347.
GeneIDi12061.
KEGGimmu:12061.
UCSCiuc007oyn.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U47281 Genomic DNA. Translation: AAA99778.1.
U44436 Genomic DNA. Translation: AAD00029.1.
CCDSiCCDS26155.1.
PIRiJC4681.
RefSeqiNP_031565.1. NM_007539.2.
UniGeneiMm.377078.

3D structure databases

ProteinModelPortaliQ61125.
SMRiQ61125. Positions 46-334.
ModBaseiSearch...
MobiDBiSearch...

Chemistry

BindingDBiQ61125.
ChEMBLiCHEMBL1250407.
GuidetoPHARMACOLOGYi41.

Protein family/group databases

GPCRDBiSearch...

Proteomic databases

PRIDEiQ61125.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000041229; ENSMUSP00000045335; ENSMUSG00000041347.
ENSMUST00000182899; ENSMUSP00000138118; ENSMUSG00000041347.
GeneIDi12061.
KEGGimmu:12061.
UCSCiuc007oyn.1. mouse.

Organism-specific databases

CTDi623.
MGIiMGI:88144. Bdkrb1.

Phylogenomic databases

eggNOGiNOG327312.
GeneTreeiENSGT00760000119055.
HOGENOMiHOG000010314.
HOVERGENiHBG103183.
InParanoidiQ61125.
KOiK03915.
OMAiPYHFFAF.
OrthoDBiEOG7K9K36.
PhylomeDBiQ61125.
TreeFamiTF330024.

Enzyme and pathway databases

ReactomeiREACT_319210. Peptide ligand-binding receptors.
REACT_331048. G alpha (i) signalling events.
REACT_347934. G alpha (q) signalling events.

Miscellaneous databases

NextBioi280369.
PROiQ61125.
SOURCEiSearch...

Gene expression databases

BgeeiQ61125.
CleanExiMM_BDKRB1.
ExpressionAtlasiQ61125. baseline and differential.
GenevestigatoriQ61125.

Family and domain databases

InterProiIPR001186. Brdyknn_1_rcpt.
IPR000496. Brdyknn_rcpt.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00425. BRADYKININR.
PR00993. BRADYKINNB1R.
PR00237. GPCRRHODOPSN.
PROSITEiPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Molecular cloning and functional characterization of a mouse bradykinin B1 receptor gene."
    Pesquero J.B., Pesquero J.L., Oliveira S.M., Roscher A.A., Metzger R., Ganten D., Bader M.
    Biochem. Biophys. Res. Commun. 220:219-225(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], INDUCTION.
    Strain: 129/SvJ.
  2. "Novel pharmacological selectivity of the cloned murine B1 bradykinin receptor."
    Yanagawa T., Prado G.N., Paquet J.L., Bestian S., Cousins B., Navarro J.
    Submitted (JAN-1996) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

Entry informationi

Entry nameiBKRB1_MOUSE
AccessioniPrimary (citable) accession number: Q61125
Secondary accession number(s): Q9Z1F4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 27, 2001
Last sequence update: November 1, 1996
Last modified: April 1, 2015
This is version 123 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.