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Q61124 (CLN3_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 103. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Battenin
Alternative name(s):
Protein CLN3
Gene names
Name:Cln3
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length438 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Involved in microtubule-dependent, anterograde transport of late endosomes and lysosomes By similarity.

Subunit structure

Interacts with DCTN1 and KIF3A By similarity. Interacts with RAB7A and RILP By similarity.

Subcellular location

Lysosome membrane; Multi-pass membrane protein By similarity. Late endosome By similarity.

Sequence similarities

Belongs to the battenin family.

Ontologies

Keywords
   Biological processTransport
   Cellular componentEndosome
Lysosome
Membrane
   DomainTransmembrane
Transmembrane helix
   PTMGlycoprotein
Lipoprotein
Methylation
Phosphoprotein
Prenylation
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processaction potential

Inferred from mutant phenotype PubMed 16412658. Source: MGI

amino acid transport

Inferred from mutant phenotype PubMed 16412658. Source: MGI

amyloid precursor protein catabolic process

Inferred from sequence or structural similarity. Source: UniProtKB

arginine transport

Inferred from sequence or structural similarity. Source: UniProtKB

associative learning

Inferred from mutant phenotype PubMed 15885820. Source: MGI

autophagic vacuole fusion

Inferred from mutant phenotype PubMed 16714284. Source: MGI

cellular amino acid metabolic process

Inferred from mutant phenotype PubMed 12763292. Source: MGI

ceramide metabolic process

Inferred from sequence or structural similarity. Source: UniProtKB

cytosolic calcium ion homeostasis

Inferred from direct assay PubMed 17189291. Source: MGI

galactosylceramide metabolic process

Inferred from sequence or structural similarity. Source: UniProtKB

globoside metabolic process

Inferred from sequence or structural similarity. Source: UniProtKB

glucosylceramide metabolic process

Inferred from sequence or structural similarity. Source: UniProtKB

ionotropic glutamate receptor signaling pathway

Inferred from mutant phenotype PubMed 16483786. Source: MGI

lysosomal lumen acidification

Inferred from sequence or structural similarity. Source: UniProtKB

lysosomal lumen pH elevation

Inferred from sequence or structural similarity. Source: UniProtKB

lysosome organization

Inferred from mutant phenotype PubMed 10191119PubMed 10440905PubMed 10527801PubMed 15588329. Source: MGI

macroautophagy

Inferred from mutant phenotype PubMed 16714284. Source: MGI

membrane organization

Inferred from mutant phenotype PubMed 15588329. Source: MGI

negative regulation of apoptotic process

Inferred from sequence or structural similarity. Source: UniProtKB

negative regulation of catalytic activity

Inferred from mutant phenotype PubMed 17868323. Source: MGI

negative regulation of macroautophagy

Inferred from mutant phenotype PubMed 16714284. Source: MGI

negative regulation of neuron apoptotic process

Inferred from direct assay PubMed 17189291. Source: MGI

negative regulation of proteolysis

Inferred from mutant phenotype PubMed 10527801. Source: MGI

neuromuscular process controlling balance

Inferred from mutant phenotype PubMed 16483786. Source: MGI

neurotransmitter metabolic process

Inferred from mutant phenotype PubMed 16239221. Source: MGI

protein processing

Inferred from mutant phenotype PubMed 15588329. Source: MGI

receptor-mediated endocytosis

Inferred from sequence or structural similarity. Source: UniProtKB

regulation of gene expression

Inferred from sequence orthology PubMed 17868323. Source: MGI

sphingomyelin metabolic process

Inferred from sequence or structural similarity. Source: UniProtKB

vacuolar transport

Inferred from Biological aspect of Ancestor. Source: RefGenome

vesicle transport along microtubule

Inferred from sequence or structural similarity. Source: UniProtKB

   Cellular_componentGolgi apparatus

Inferred from sequence or structural similarity. Source: UniProtKB

Golgi membrane

Inferred from sequence or structural similarity. Source: UniProtKB

Golgi stack

Inferred from sequence or structural similarity. Source: UniProtKB

autophagic vacuole

Inferred from direct assay PubMed 16714284. Source: MGI

caveola

Inferred from sequence or structural similarity. Source: UniProtKB

cytoplasm

Inferred from sequence or structural similarity. Source: UniProtKB

cytoplasmic vesicle

Inferred from direct assay PubMed 17189291. Source: MGI

early endosome

Inferred from sequence or structural similarity. Source: UniProtKB

endoplasmic reticulum

Inferred from sequence or structural similarity. Source: UniProtKB

integral component of endoplasmic reticulum membrane

Inferred from sequence or structural similarity. Source: UniProtKB

integral component of membrane

Inferred from sequence or structural similarity. Source: UniProtKB

integral component of organelle membrane

Inferred from Biological aspect of Ancestor. Source: RefGenome

late endosome

Inferred from direct assay PubMed 15588329. Source: MGI

lysosomal membrane

Inferred from sequence or structural similarity. Source: UniProtKB

lysosome

Inferred from direct assay PubMed 15588329PubMed 16714284. Source: MGI

membrane raft

Inferred from sequence or structural similarity. Source: UniProtKB

neuron projection

Inferred from sequence or structural similarity. Source: UniProtKB

nucleus

Inferred from sequence or structural similarity. Source: UniProtKB

plasma membrane

Inferred from sequence or structural similarity. Source: UniProtKB

synaptic vesicle

Inferred from sequence or structural similarity. Source: UniProtKB

trans-Golgi network

Inferred from sequence or structural similarity. Source: UniProtKB

   Molecular_functioncalcium-dependent protein binding

Inferred from physical interaction PubMed 17189291. Source: MGI

protein binding

Inferred from physical interaction PubMed 17189291. Source: MGI

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 435435Battenin
PRO_0000089859
Propeptide436 – 4383Removed in mature form By similarity
PRO_0000422292

Regions

Transmembrane38 – 5821Helical; Potential
Transmembrane99 – 11921Helical; Potential
Transmembrane128 – 14821Helical; Potential
Transmembrane187 – 20721Helical; Potential
Transmembrane212 – 23221Helical; Potential
Transmembrane278 – 29821Helical; Potential
Transmembrane358 – 37821Helical; Potential
Transmembrane407 – 42721Helical; Potential

Amino acid modifications

Modified residue141Phosphoserine Ref.5
Modified residue4351Cysteine methyl ester By similarity
Lipidation4351S-farnesyl cysteine By similarity
Glycosylation711N-linked (GlcNAc...) Potential
Glycosylation851N-linked (GlcNAc...) Potential
Glycosylation3101N-linked (GlcNAc...) Potential

Experimental info

Sequence conflict791P → R in AAC52957. Ref.1
Sequence conflict1201H → Y in AAB07595. Ref.2
Sequence conflict2371L → W in AAC52957. Ref.1
Sequence conflict317 – 3182QQ → HE in AAC52957. Ref.1
Sequence conflict3801Y → H in AAC52957. Ref.1

Sequences

Sequence LengthMass (Da)Tools
Q61124 [UniParc].

Last modified July 27, 2011. Version 2.
Checksum: 2A06D2CE4728C1AC

FASTA43847,657
        10         20         30         40         50         60 
MGSSAGSWRR LEDSEREETD SEPQAPRLDS RSVLWKNAVG FWILGLCNNF SYVVMLSAAH 

        70         80         90        100        110        120 
DILKQEQASG NQSHVEPGPT PTPHNSSSRF DCNSISTAAV LLADILPTLV IKLLAPLGLH 

       130        140        150        160        170        180 
LLPYSPRVLV SGVCSAGSFV LVAFSQSVGL SLCGVVLASI SSGLGEVTFL SLTAFYPSAV 

       190        200        210        220        230        240 
ISWWSSGTGG AGLLGSLSYL GLTQAGLSPQ HTLLSMLGIP VLLLASYFLL LTSPEPLDPG 

       250        260        270        280        290        300 
GENEAETAAR QPLIGTETPE SKPGASWDLS LQERWTVFKG LLWYIIPLVL VYFAEYFINQ 

       310        320        330        340        350        360 
GLFELLFFRN TSLSHAQQYR WYQMLYQAGV FASRSSLQCC RIRFTWVLAL LQCLNLALLL 

       370        380        390        400        410        420 
ADVCLNFLPS IYLIFIIILY EGLLGGAAYV NTFHNIALET SDKHREFAME AACISDTLGI 

       430 
SLSGVLALPL HDFLCHLP 

« Hide

References

« Hide 'large scale' references
[1]"Isolation and chromosomal mapping of a mouse homolog of the Batten disease gene CLN3."
Lee R.L., Johnson K.R., Lerner T.J.
Genomics 35:617-619(1996) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Teratocarcinoma.
[2]"Cross-species homology of the CLN3 gene."
Taschner P.E.M., de Vos N., Breuning M.H.
Neuropediatrics 28:18-20(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Strain: BALB/c.
Tissue: Liver.
[3]"Immunochemical localization of the Batten disease (CLN3) protein in retina."
Katz M.L., Gao C.-L., Prabhakaram M., Shibuya H., Liu P.-C., Johnson G.S.
Submitted (MAR-1997) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Strain: C57BL/6.
[4]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: FVB/N.
Tissue: Colon and Mammary tumor.
[5]"The phagosomal proteome in interferon-gamma-activated macrophages."
Trost M., English L., Lemieux S., Courcelles M., Desjardins M., Thibault P.
Immunity 30:143-154(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-14, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
U47106 mRNA. Translation: AAC52957.1.
U68064 mRNA. Translation: AAB07595.1.
U92811 mRNA. Translation: AAB69983.1.
BC058753 mRNA. Translation: AAH58753.1.
BC080759 mRNA. Translation: AAH80759.1.
CCDSCCDS21833.1.
RefSeqNP_001139783.1. NM_001146311.1.
NP_034037.3. NM_009907.3.
XP_006507351.1. XM_006507288.1.
XP_006507352.1. XM_006507289.1.
XP_006507353.1. XM_006507290.1.
XP_006507354.1. XM_006507291.1.
XP_006507355.1. XM_006507292.1.
XP_006507356.1. XM_006507293.1.
XP_006507357.1. XM_006507294.1.
XP_006507358.1. XM_006507295.1.
UniGeneMm.268930.

3D structure databases

ProteinModelPortalQ61124.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING10090.ENSMUSP00000081636.

Protein family/group databases

TCDB2.A.57.5.1. the equilibrative nucleoside transporter (ent) family.

PTM databases

PhosphoSiteQ61124.

Proteomic databases

PRIDEQ61124.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000032962; ENSMUSP00000032962; ENSMUSG00000030720.
ENSMUST00000084589; ENSMUSP00000081636; ENSMUSG00000030720.
ENSMUST00000116269; ENSMUSP00000111973; ENSMUSG00000030720.
GeneID12752.
KEGGmmu:12752.
UCSCuc009jrx.2. mouse.

Organism-specific databases

CTD1201.
MGIMGI:107537. Cln3.

Phylogenomic databases

eggNOGNOG325947.
GeneTreeENSGT00390000003249.
HOGENOMHOG000164765.
HOVERGENHBG017297.
InParanoidO35934.
KOK12389.
OMANYGYVVM.
OrthoDBEOG7N8ZZQ.
TreeFamTF314055.

Gene expression databases

ArrayExpressQ61124.
BgeeQ61124.
GenevestigatorQ61124.

Family and domain databases

InterProIPR003492. Battenin_disease_Cln3.
IPR018460. Battenin_disease_Cln3_subgr.
IPR016196. MFS_dom_general_subst_transpt.
[Graphical view]
PANTHERPTHR10981. PTHR10981. 1 hit.
PfamPF02487. CLN3. 1 hit.
[Graphical view]
PIRSFPIRSF015974. CLN3_BTN1. 1 hit.
PRINTSPR01315. BATTENIN.
SUPFAMSSF103473. SSF103473. 1 hit.
ProtoNetSearch...

Other

NextBio282088.
PROQ61124.
SOURCESearch...

Entry information

Entry nameCLN3_MOUSE
AccessionPrimary (citable) accession number: Q61124
Secondary accession number(s): O35934, P70400
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: July 27, 2011
Last modified: July 9, 2014
This is version 103 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot