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Q61124

- CLN3_MOUSE

UniProt

Q61124 - CLN3_MOUSE

Protein

Battenin

Gene

Cln3

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 104 (01 Oct 2014)
      Sequence version 2 (27 Jul 2011)
      Previous versions | rss
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    Functioni

    Involved in microtubule-dependent, anterograde transport of late endosomes and lysosomes.By similarity

    GO - Molecular functioni

    1. calcium-dependent protein binding Source: MGI
    2. protein binding Source: MGI

    GO - Biological processi

    1. action potential Source: MGI
    2. amino acid transport Source: MGI
    3. amyloid precursor protein catabolic process Source: UniProtKB
    4. arginine transport Source: UniProtKB
    5. associative learning Source: MGI
    6. autophagic vacuole fusion Source: MGI
    7. cellular amino acid metabolic process Source: MGI
    8. ceramide metabolic process Source: UniProtKB
    9. cytosolic calcium ion homeostasis Source: MGI
    10. galactosylceramide metabolic process Source: UniProtKB
    11. globoside metabolic process Source: UniProtKB
    12. glucosylceramide metabolic process Source: UniProtKB
    13. ionotropic glutamate receptor signaling pathway Source: MGI
    14. lysosomal lumen acidification Source: UniProtKB
    15. lysosomal lumen pH elevation Source: UniProtKB
    16. lysosome organization Source: MGI
    17. macroautophagy Source: MGI
    18. membrane organization Source: MGI
    19. negative regulation of apoptotic process Source: UniProtKB
    20. negative regulation of catalytic activity Source: MGI
    21. negative regulation of macroautophagy Source: MGI
    22. negative regulation of neuron apoptotic process Source: MGI
    23. negative regulation of proteolysis Source: MGI
    24. neuromuscular process controlling balance Source: MGI
    25. neurotransmitter metabolic process Source: MGI
    26. protein processing Source: MGI
    27. receptor-mediated endocytosis Source: UniProtKB
    28. regulation of gene expression Source: MGI
    29. sphingomyelin metabolic process Source: UniProtKB
    30. vacuolar transport Source: RefGenome
    31. vesicle transport along microtubule Source: UniProtKB

    Keywords - Biological processi

    Transport

    Protein family/group databases

    TCDBi2.A.57.5.1. the equilibrative nucleoside transporter (ent) family.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Battenin
    Alternative name(s):
    Protein CLN3
    Gene namesi
    Name:Cln3
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 7

    Organism-specific databases

    MGIiMGI:107537. Cln3.

    Subcellular locationi

    Lysosome membrane By similarity; Multi-pass membrane protein By similarity. Late endosome By similarity

    GO - Cellular componenti

    1. autophagic vacuole Source: MGI
    2. caveola Source: UniProtKB
    3. cytoplasm Source: UniProtKB
    4. cytoplasmic vesicle Source: MGI
    5. early endosome Source: UniProtKB
    6. endoplasmic reticulum Source: UniProtKB
    7. Golgi apparatus Source: UniProtKB
    8. Golgi membrane Source: UniProtKB
    9. Golgi stack Source: UniProtKB
    10. integral component of endoplasmic reticulum membrane Source: UniProtKB
    11. integral component of membrane Source: UniProtKB
    12. integral component of organelle membrane Source: RefGenome
    13. late endosome Source: MGI
    14. lysosomal membrane Source: UniProtKB
    15. lysosome Source: MGI
    16. membrane raft Source: UniProtKB
    17. neuron projection Source: UniProtKB
    18. nucleus Source: UniProtKB
    19. plasma membrane Source: UniProtKB
    20. synaptic vesicle Source: UniProtKB
    21. trans-Golgi network Source: UniProtKB

    Keywords - Cellular componenti

    Endosome, Lysosome, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 435435BatteninPRO_0000089859Add
    BLAST
    Propeptidei436 – 4383Removed in mature formBy similarityPRO_0000422292

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei14 – 141Phosphoserine1 Publication
    Glycosylationi71 – 711N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi85 – 851N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi310 – 3101N-linked (GlcNAc...)Sequence Analysis
    Modified residuei435 – 4351Cysteine methyl esterBy similarity
    Lipidationi435 – 4351S-farnesyl cysteineBy similarity

    Keywords - PTMi

    Glycoprotein, Lipoprotein, Methylation, Phosphoprotein, Prenylation

    Proteomic databases

    PRIDEiQ61124.

    PTM databases

    PhosphoSiteiQ61124.

    Expressioni

    Gene expression databases

    ArrayExpressiQ61124.
    BgeeiQ61124.
    GenevestigatoriQ61124.

    Interactioni

    Subunit structurei

    Interacts with DCTN1 and KIF3A. Interacts with RAB7A and RILP.By similarity

    Protein-protein interaction databases

    STRINGi10090.ENSMUSP00000081636.

    Structurei

    3D structure databases

    ProteinModelPortaliQ61124.
    ModBaseiSearch...
    MobiDBiSearch...

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei38 – 5821HelicalSequence AnalysisAdd
    BLAST
    Transmembranei99 – 11921HelicalSequence AnalysisAdd
    BLAST
    Transmembranei128 – 14821HelicalSequence AnalysisAdd
    BLAST
    Transmembranei187 – 20721HelicalSequence AnalysisAdd
    BLAST
    Transmembranei212 – 23221HelicalSequence AnalysisAdd
    BLAST
    Transmembranei278 – 29821HelicalSequence AnalysisAdd
    BLAST
    Transmembranei358 – 37821HelicalSequence AnalysisAdd
    BLAST
    Transmembranei407 – 42721HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the battenin family.Curated

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG325947.
    GeneTreeiENSGT00390000003249.
    HOGENOMiHOG000164765.
    HOVERGENiHBG017297.
    InParanoidiO35934.
    KOiK12389.
    OMAiNYGYVVM.
    OrthoDBiEOG7N8ZZQ.
    TreeFamiTF314055.

    Family and domain databases

    InterProiIPR003492. Battenin_disease_Cln3.
    IPR018460. Battenin_disease_Cln3_subgr.
    IPR016196. MFS_dom_general_subst_transpt.
    [Graphical view]
    PANTHERiPTHR10981. PTHR10981. 1 hit.
    PfamiPF02487. CLN3. 1 hit.
    [Graphical view]
    PIRSFiPIRSF015974. CLN3_BTN1. 1 hit.
    PRINTSiPR01315. BATTENIN.
    SUPFAMiSSF103473. SSF103473. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q61124-1 [UniParc]FASTAAdd to Basket

    « Hide

    MGSSAGSWRR LEDSEREETD SEPQAPRLDS RSVLWKNAVG FWILGLCNNF    50
    SYVVMLSAAH DILKQEQASG NQSHVEPGPT PTPHNSSSRF DCNSISTAAV 100
    LLADILPTLV IKLLAPLGLH LLPYSPRVLV SGVCSAGSFV LVAFSQSVGL 150
    SLCGVVLASI SSGLGEVTFL SLTAFYPSAV ISWWSSGTGG AGLLGSLSYL 200
    GLTQAGLSPQ HTLLSMLGIP VLLLASYFLL LTSPEPLDPG GENEAETAAR 250
    QPLIGTETPE SKPGASWDLS LQERWTVFKG LLWYIIPLVL VYFAEYFINQ 300
    GLFELLFFRN TSLSHAQQYR WYQMLYQAGV FASRSSLQCC RIRFTWVLAL 350
    LQCLNLALLL ADVCLNFLPS IYLIFIIILY EGLLGGAAYV NTFHNIALET 400
    SDKHREFAME AACISDTLGI SLSGVLALPL HDFLCHLP 438
    Length:438
    Mass (Da):47,657
    Last modified:July 27, 2011 - v2
    Checksum:i2A06D2CE4728C1AC
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti79 – 791P → R in AAC52957. (PubMed:8812504)Curated
    Sequence conflicti120 – 1201H → Y in AAB07595. (PubMed:9151313)Curated
    Sequence conflicti237 – 2371L → W in AAC52957. (PubMed:8812504)Curated
    Sequence conflicti317 – 3182QQ → HE in AAC52957. (PubMed:8812504)Curated
    Sequence conflicti380 – 3801Y → H in AAC52957. (PubMed:8812504)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U47106 mRNA. Translation: AAC52957.1.
    U68064 mRNA. Translation: AAB07595.1.
    U92811 mRNA. Translation: AAB69983.1.
    BC058753 mRNA. Translation: AAH58753.1.
    BC080759 mRNA. Translation: AAH80759.1.
    CCDSiCCDS21833.1.
    RefSeqiNP_001139783.1. NM_001146311.1.
    NP_034037.3. NM_009907.3.
    XP_006507351.1. XM_006507288.1.
    XP_006507352.1. XM_006507289.1.
    XP_006507353.1. XM_006507290.1.
    XP_006507354.1. XM_006507291.1.
    XP_006507355.1. XM_006507292.1.
    XP_006507356.1. XM_006507293.1.
    XP_006507357.1. XM_006507294.1.
    XP_006507358.1. XM_006507295.1.
    UniGeneiMm.268930.

    Genome annotation databases

    EnsembliENSMUST00000032962; ENSMUSP00000032962; ENSMUSG00000030720.
    ENSMUST00000084589; ENSMUSP00000081636; ENSMUSG00000030720.
    ENSMUST00000116269; ENSMUSP00000111973; ENSMUSG00000030720.
    GeneIDi12752.
    KEGGimmu:12752.
    UCSCiuc009jrx.2. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U47106 mRNA. Translation: AAC52957.1 .
    U68064 mRNA. Translation: AAB07595.1 .
    U92811 mRNA. Translation: AAB69983.1 .
    BC058753 mRNA. Translation: AAH58753.1 .
    BC080759 mRNA. Translation: AAH80759.1 .
    CCDSi CCDS21833.1.
    RefSeqi NP_001139783.1. NM_001146311.1.
    NP_034037.3. NM_009907.3.
    XP_006507351.1. XM_006507288.1.
    XP_006507352.1. XM_006507289.1.
    XP_006507353.1. XM_006507290.1.
    XP_006507354.1. XM_006507291.1.
    XP_006507355.1. XM_006507292.1.
    XP_006507356.1. XM_006507293.1.
    XP_006507357.1. XM_006507294.1.
    XP_006507358.1. XM_006507295.1.
    UniGenei Mm.268930.

    3D structure databases

    ProteinModelPortali Q61124.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 10090.ENSMUSP00000081636.

    Protein family/group databases

    TCDBi 2.A.57.5.1. the equilibrative nucleoside transporter (ent) family.

    PTM databases

    PhosphoSitei Q61124.

    Proteomic databases

    PRIDEi Q61124.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000032962 ; ENSMUSP00000032962 ; ENSMUSG00000030720 .
    ENSMUST00000084589 ; ENSMUSP00000081636 ; ENSMUSG00000030720 .
    ENSMUST00000116269 ; ENSMUSP00000111973 ; ENSMUSG00000030720 .
    GeneIDi 12752.
    KEGGi mmu:12752.
    UCSCi uc009jrx.2. mouse.

    Organism-specific databases

    CTDi 1201.
    MGIi MGI:107537. Cln3.

    Phylogenomic databases

    eggNOGi NOG325947.
    GeneTreei ENSGT00390000003249.
    HOGENOMi HOG000164765.
    HOVERGENi HBG017297.
    InParanoidi O35934.
    KOi K12389.
    OMAi NYGYVVM.
    OrthoDBi EOG7N8ZZQ.
    TreeFami TF314055.

    Miscellaneous databases

    NextBioi 282088.
    PROi Q61124.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q61124.
    Bgeei Q61124.
    Genevestigatori Q61124.

    Family and domain databases

    InterProi IPR003492. Battenin_disease_Cln3.
    IPR018460. Battenin_disease_Cln3_subgr.
    IPR016196. MFS_dom_general_subst_transpt.
    [Graphical view ]
    PANTHERi PTHR10981. PTHR10981. 1 hit.
    Pfami PF02487. CLN3. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF015974. CLN3_BTN1. 1 hit.
    PRINTSi PR01315. BATTENIN.
    SUPFAMi SSF103473. SSF103473. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Isolation and chromosomal mapping of a mouse homolog of the Batten disease gene CLN3."
      Lee R.L., Johnson K.R., Lerner T.J.
      Genomics 35:617-619(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Teratocarcinoma.
    2. "Cross-species homology of the CLN3 gene."
      Taschner P.E.M., de Vos N., Breuning M.H.
      Neuropediatrics 28:18-20(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: BALB/c.
      Tissue: Liver.
    3. "Immunochemical localization of the Batten disease (CLN3) protein in retina."
      Katz M.L., Gao C.-L., Prabhakaram M., Shibuya H., Liu P.-C., Johnson G.S.
      Submitted (MAR-1997) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: C57BL/6.
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: FVB/N.
      Tissue: Colon and Mammary tumor.
    5. "The phagosomal proteome in interferon-gamma-activated macrophages."
      Trost M., English L., Lemieux S., Courcelles M., Desjardins M., Thibault P.
      Immunity 30:143-154(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-14, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiCLN3_MOUSE
    AccessioniPrimary (citable) accession number: Q61124
    Secondary accession number(s): O35934, P70400
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1997
    Last sequence update: July 27, 2011
    Last modified: October 1, 2014
    This is version 104 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3