Q61124 (CLN3_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Battenin

Alternative name(s):
Protein CLN3

Gene names

Name:

Cln3

Organism

Mus musculus (Mouse) [Reference proteome]

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length	438 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Involved in microtubule-dependent, anterograde transport of late endosomes and lysosomes By similarity.
Subunit structure	Interacts with DCTN1 and KIF3A By similarity. Interacts with RAB7A and RILP By similarity.
Subcellular location	Lysosome membrane; Multi-pass membrane protein By similarity. Late endosome By similarity.
Sequence similarities	Belongs to the battenin family.

Ontologies

Keywords
Biological process	Transport
Cellular component	Endosome Lysosome Membrane
Domain	Transmembrane Transmembrane helix
PTM	Glycoprotein Lipoprotein Methylation Phosphoprotein Prenylation
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	amyloid precursor protein catabolic process Inferred from sequence or structural similarity. Source: UniProtKB arginine transport Inferred from sequence or structural similarity. Source: UniProtKB associative learning Inferred from mutant phenotype PubMed 15885820. Source: MGI autophagic vacuole fusion Inferred from mutant phenotype PubMed 16714284. Source: MGI cellular amino acid metabolic process Inferred from mutant phenotype PubMed 12763292. Source: MGI cytosolic calcium ion homeostasis Inferred from direct assay PubMed 17189291. Source: MGI galactosylceramide metabolic process Inferred from sequence or structural similarity. Source: UniProtKB globoside metabolic process Inferred from sequence or structural similarity. Source: UniProtKB glucosylceramide metabolic process Inferred from sequence or structural similarity. Source: UniProtKB ionotropic glutamate receptor signaling pathway Inferred from mutant phenotype PubMed 16483786. Source: MGI lysosomal lumen acidification Inferred from sequence or structural similarity. Source: UniProtKB lysosomal lumen pH elevation Inferred from sequence or structural similarity. Source: UniProtKB negative regulation of catalytic activity Inferred from mutant phenotype PubMed 17868323. Source: MGI negative regulation of macroautophagy Inferred from mutant phenotype PubMed 16714284. Source: MGI negative regulation of neuron apoptotic process Inferred from direct assay PubMed 17189291. Source: MGI negative regulation of proteolysis Inferred from mutant phenotype PubMed 10527801. Source: MGI neuromuscular process controlling balance Inferred from mutant phenotype PubMed 16483786. Source: MGI neurotransmitter metabolic process Inferred from mutant phenotype PubMed 16239221. Source: MGI protein processing Inferred from mutant phenotype PubMed 15588329. Source: MGI receptor-mediated endocytosis Inferred from sequence or structural similarity. Source: UniProtKB regulation of action potential Inferred from mutant phenotype PubMed 16412658. Source: MGI regulation of gene expression Inferred from sequence orthology PubMed 17868323. Source: MGI sphingomyelin metabolic process Inferred from sequence or structural similarity. Source: UniProtKB vacuolar transport Inferred from Biological aspect of Ancestor. Source: RefGenome vesicle transport along microtubule Inferred from sequence or structural similarity. Source: UniProtKB
Cellular_component	Golgi membrane Inferred from sequence or structural similarity. Source: UniProtKB Golgi stack Inferred from sequence or structural similarity. Source: UniProtKB autophagic vacuole Inferred from direct assay PubMed 16714284. Source: MGI caveola Inferred from sequence or structural similarity. Source: UniProtKB cytoplasmic vesicle part Inferred from direct assay PubMed 17189291. Source: MGI early endosome Inferred from sequence or structural similarity. Source: UniProtKB integral to endoplasmic reticulum membrane Inferred from sequence or structural similarity. Source: UniProtKB late endosome Inferred from direct assay PubMed 15588329. Source: MGI lysosomal membrane Inferred from sequence or structural similarity. Source: UniProtKB neuron projection Inferred from sequence or structural similarity. Source: UniProtKB nucleus Inferred from sequence or structural similarity. Source: UniProtKB synaptic vesicle Inferred from sequence or structural similarity. Source: UniProtKB trans-Golgi network Inferred from sequence or structural similarity. Source: UniProtKB
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 435	435	Battenin		PRO_0000089859
	Propeptide	436 – 438	3	Removed in mature form By similarity		PRO_0000422292
Regions
	Transmembrane	38 – 58	21	Helical; Potential
	Transmembrane	99 – 119	21	Helical; Potential
	Transmembrane	128 – 148	21	Helical; Potential
	Transmembrane	187 – 207	21	Helical; Potential
	Transmembrane	212 – 232	21	Helical; Potential
	Transmembrane	278 – 298	21	Helical; Potential
	Transmembrane	358 – 378	21	Helical; Potential
	Transmembrane	407 – 427	21	Helical; Potential
Amino acid modifications
	Modified residue	14	1	Phosphoserine Ref.5
	Modified residue	435	1	Cysteine methyl ester By similarity
	Lipidation	435	1	S-farnesyl cysteine By similarity
	Glycosylation	71	1	N-linked (GlcNAc...) Potential
	Glycosylation	85	1	N-linked (GlcNAc...) Potential
	Glycosylation	310	1	N-linked (GlcNAc...) Potential
Experimental info
	Sequence conflict	79	1	P → R in AAC52957. Ref.1
	Sequence conflict	120	1	H → Y in AAB07595. Ref.2
	Sequence conflict	237	1	L → W in AAC52957. Ref.1
	Sequence conflict	317 – 318	2	QQ → HE in AAC52957. Ref.1
	Sequence conflict	380	1	Y → H in AAC52957. Ref.1

Sequences

	Sequence		Length	Mass (Da)
	Q61124 [UniParc]. Last modified July 27, 2011. Version 2. Checksum: 2A06D2CE4728C1AC	FASTA	438	47,657
	10 20 30 40 50 60 MGSSAGSWRR LEDSEREETD SEPQAPRLDS RSVLWKNAVG FWILGLCNNF SYVVMLSAAH 70 80 90 100 110 120 DILKQEQASG NQSHVEPGPT PTPHNSSSRF DCNSISTAAV LLADILPTLV IKLLAPLGLH 130 140 150 160 170 180 LLPYSPRVLV SGVCSAGSFV LVAFSQSVGL SLCGVVLASI SSGLGEVTFL SLTAFYPSAV 190 200 210 220 230 240 ISWWSSGTGG AGLLGSLSYL GLTQAGLSPQ HTLLSMLGIP VLLLASYFLL LTSPEPLDPG 250 260 270 280 290 300 GENEAETAAR QPLIGTETPE SKPGASWDLS LQERWTVFKG LLWYIIPLVL VYFAEYFINQ 310 320 330 340 350 360 GLFELLFFRN TSLSHAQQYR WYQMLYQAGV FASRSSLQCC RIRFTWVLAL LQCLNLALLL 370 380 390 400 410 420 ADVCLNFLPS IYLIFIIILY EGLLGGAAYV NTFHNIALET SDKHREFAME AACISDTLGI 430 SLSGVLALPL HDFLCHLP

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Isolation and chromosomal mapping of a mouse homolog of the Batten disease gene CLN3." Lee R.L., Johnson K.R., Lerner T.J. Genomics 35:617-619(1996) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Teratocarcinoma.
[2]	"Cross-species homology of the CLN3 gene." Taschner P.E.M., de Vos N., Breuning M.H. Neuropediatrics 28:18-20(1997) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Strain: BALB/c. Tissue: Liver.
[3]	"Immunochemical localization of the Batten disease (CLN3) protein in retina." Katz M.L., Gao C.-L., Prabhakaram M., Shibuya H., Liu P.-C., Johnson G.S. Submitted (MAR-1997) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Strain: C57BL/6.
[4]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: FVB/N. Tissue: Colon and Mammary tumor.
[5]	"The phagosomal proteome in interferon-gamma-activated macrophages." Trost M., English L., Lemieux S., Courcelles M., Desjardins M., Thibault P. Immunity 30:143-154(2009) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-14, MASS SPECTROMETRY. Tissue: Macrophage.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	U47106 mRNA. Translation: AAC52957.1. U68064 mRNA. Translation: AAB07595.1. U92811 mRNA. Translation: AAB69983.1. BC058753 mRNA. Translation: AAH58753.1. BC080759 mRNA. Translation: AAH80759.1.
IPI	IPI00331157.
RefSeq	NP_001139783.1. NM_001146311.1. NP_034037.3. NM_009907.3.
UniGene	Mm.268930.
3D structure databases
ProteinModelPortal	Q61124.
ModBase	Search...
Protein-protein interaction databases
STRING	10090.ENSMUSP00000081636.
PTM databases
PhosphoSite	Q61124.
Proteomic databases
PRIDE	Q61124.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSMUST00000032962; ENSMUSP00000032962; ENSMUSG00000030720. ENSMUST00000084589; ENSMUSP00000081636; ENSMUSG00000030720. ENSMUST00000116269; ENSMUSP00000111973; ENSMUSG00000030720.
GeneID	12752.
KEGG	mmu:12752.
Organism-specific databases
CTD	1201.
MGI	MGI:107537. Cln3.
Phylogenomic databases
eggNOG	NOG325947.
GeneTree	ENSGT00390000003249.
HOGENOM	HOG000164765.
HOVERGEN	HBG017297.
InParanoid	O35934.
KO	K12389.
OMA	NYGYVVM.
OrthoDB	EOG4TF0KG.
Gene expression databases
ArrayExpress	Q61124.
Bgee	Q61124.
Genevestigator	Q61124.
GermOnline	ENSMUSG00000030720. Mus musculus.
Family and domain databases
InterPro	IPR003492. Battenin_disease_Cln3. IPR018460. Battenin_disease_Cln3_subgr. IPR016196. MFS_dom_general_subst_transpt. [Graphical view]
PANTHER	PTHR10981. PTHR10981. 1 hit.
Pfam	PF02487. CLN3. 1 hit. [Graphical view]
PIRSF	PIRSF015974. CLN3_BTN1. 1 hit.
PRINTS	PR01315. BATTENIN.
SUPFAM	SSF103473. MFS_gen_substrate_transporter. 1 hit.
ProtoNet	Search...
Other
NextBio	282088.
SOURCE	Search...

Entry information

Entry name

CLN3_MOUSE

Accession

Primary (citable) accession number: Q61124
Secondary accession number(s): O35934, P70400

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1997
Last sequence update:	July 27, 2011
Last modified:	May 1, 2013
This is version 92 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program