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Q61124

- CLN3_MOUSE

UniProt

Q61124 - CLN3_MOUSE

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Protein

Battenin

Gene

Cln3

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Involved in microtubule-dependent, anterograde transport of late endosomes and lysosomes.By similarity

GO - Molecular functioni

  1. calcium-dependent protein binding Source: MGI

GO - Biological processi

  1. action potential Source: MGI
  2. amino acid transport Source: MGI
  3. amyloid precursor protein catabolic process Source: UniProtKB
  4. arginine transport Source: UniProtKB
  5. associative learning Source: MGI
  6. autophagic vacuole fusion Source: MGI
  7. cellular amino acid metabolic process Source: MGI
  8. ceramide metabolic process Source: UniProtKB
  9. cytosolic calcium ion homeostasis Source: MGI
  10. galactosylceramide metabolic process Source: UniProtKB
  11. globoside metabolic process Source: UniProtKB
  12. glucosylceramide metabolic process Source: UniProtKB
  13. ionotropic glutamate receptor signaling pathway Source: MGI
  14. lysosomal lumen acidification Source: UniProtKB
  15. lysosomal lumen pH elevation Source: UniProtKB
  16. lysosome organization Source: MGI
  17. macroautophagy Source: MGI
  18. membrane organization Source: MGI
  19. negative regulation of apoptotic process Source: UniProtKB
  20. negative regulation of catalytic activity Source: MGI
  21. negative regulation of macroautophagy Source: MGI
  22. negative regulation of neuron apoptotic process Source: MGI
  23. negative regulation of proteolysis Source: MGI
  24. neuromuscular process controlling balance Source: MGI
  25. neurotransmitter metabolic process Source: MGI
  26. protein processing Source: MGI
  27. receptor-mediated endocytosis Source: UniProtKB
  28. regulation of gene expression Source: MGI
  29. sphingomyelin metabolic process Source: UniProtKB
  30. vacuolar transport Source: RefGenome
  31. vesicle transport along microtubule Source: UniProtKB
Complete GO annotation...

Keywords - Biological processi

Transport

Protein family/group databases

TCDBi2.A.57.5.1. the equilibrative nucleoside transporter (ent) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Battenin
Alternative name(s):
Protein CLN3
Gene namesi
Name:Cln3
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 7

Organism-specific databases

MGIiMGI:107537. Cln3.

Subcellular locationi

Lysosome membrane By similarity; Multi-pass membrane protein By similarity. Late endosome By similarity

GO - Cellular componenti

  1. autophagic vacuole Source: MGI
  2. caveola Source: UniProtKB
  3. cytoplasm Source: UniProtKB
  4. cytoplasmic vesicle Source: MGI
  5. early endosome Source: UniProtKB
  6. endoplasmic reticulum Source: UniProtKB
  7. Golgi apparatus Source: UniProtKB
  8. Golgi membrane Source: UniProtKB
  9. Golgi stack Source: UniProtKB
  10. integral component of endoplasmic reticulum membrane Source: UniProtKB
  11. integral component of membrane Source: UniProtKB
  12. integral component of organelle membrane Source: RefGenome
  13. late endosome Source: MGI
  14. lysosomal membrane Source: UniProtKB
  15. lysosome Source: MGI
  16. membrane raft Source: UniProtKB
  17. neuron projection Source: UniProtKB
  18. nucleus Source: UniProtKB
  19. plasma membrane Source: UniProtKB
  20. synaptic vesicle Source: UniProtKB
  21. trans-Golgi network Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Endosome, Lysosome, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 435435BatteninPRO_0000089859Add
BLAST
Propeptidei436 – 4383Removed in mature formBy similarityPRO_0000422292

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei14 – 141Phosphoserine1 Publication
Glycosylationi71 – 711N-linked (GlcNAc...)Sequence Analysis
Glycosylationi85 – 851N-linked (GlcNAc...)Sequence Analysis
Glycosylationi310 – 3101N-linked (GlcNAc...)Sequence Analysis
Modified residuei435 – 4351Cysteine methyl esterBy similarity
Lipidationi435 – 4351S-farnesyl cysteineBy similarity

Keywords - PTMi

Glycoprotein, Lipoprotein, Methylation, Phosphoprotein, Prenylation

Proteomic databases

MaxQBiQ61124.
PRIDEiQ61124.

PTM databases

PhosphoSiteiQ61124.

Expressioni

Gene expression databases

BgeeiQ61124.
ExpressionAtlasiQ61124. baseline and differential.
GenevestigatoriQ61124.

Interactioni

Subunit structurei

Interacts with DCTN1 and KIF3A. Interacts with RAB7A and RILP.By similarity

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000081636.

Structurei

3D structure databases

ProteinModelPortaliQ61124.
ModBaseiSearch...
MobiDBiSearch...

Topological domain

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 3737CytoplasmicSequence AnalysisAdd
BLAST
Topological domaini59 – 12769LumenalSequence AnalysisAdd
BLAST
Topological domaini149 – 1513CytoplasmicSequence Analysis
Topological domaini173 – 18210LumenalSequence Analysis
Topological domaini204 – 27774CytoplasmicSequence AnalysisAdd
BLAST
Topological domaini299 – 34648LumenalSequence AnalysisAdd
BLAST
Topological domaini368 – 43871CytoplasmicSequence AnalysisAdd
BLAST

Transmembrane

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei38 – 5821HelicalSequence AnalysisAdd
BLAST
Transmembranei128 – 14821HelicalSequence AnalysisAdd
BLAST
Transmembranei152 – 17221HelicalSequence AnalysisAdd
BLAST
Transmembranei183 – 20321HelicalSequence AnalysisAdd
BLAST
Transmembranei278 – 29821HelicalSequence AnalysisAdd
BLAST
Transmembranei347 – 36721HelicalSequence AnalysisAdd
BLAST

Family & Domainsi

Sequence similaritiesi

Belongs to the battenin family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG325947.
GeneTreeiENSGT00390000003249.
HOGENOMiHOG000164765.
HOVERGENiHBG017297.
InParanoidiQ61124.
KOiK12389.
OMAiNYGYVVM.
OrthoDBiEOG7N8ZZQ.
TreeFamiTF314055.

Family and domain databases

InterProiIPR003492. Battenin_disease_Cln3.
IPR018460. Battenin_disease_Cln3_subgr.
IPR016196. MFS_dom_general_subst_transpt.
[Graphical view]
PANTHERiPTHR10981. PTHR10981. 1 hit.
PfamiPF02487. CLN3. 1 hit.
[Graphical view]
PIRSFiPIRSF015974. CLN3_BTN1. 1 hit.
PRINTSiPR01315. BATTENIN.
SUPFAMiSSF103473. SSF103473. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q61124-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MGSSAGSWRR LEDSEREETD SEPQAPRLDS RSVLWKNAVG FWILGLCNNF
60 70 80 90 100
SYVVMLSAAH DILKQEQASG NQSHVEPGPT PTPHNSSSRF DCNSISTAAV
110 120 130 140 150
LLADILPTLV IKLLAPLGLH LLPYSPRVLV SGVCSAGSFV LVAFSQSVGL
160 170 180 190 200
SLCGVVLASI SSGLGEVTFL SLTAFYPSAV ISWWSSGTGG AGLLGSLSYL
210 220 230 240 250
GLTQAGLSPQ HTLLSMLGIP VLLLASYFLL LTSPEPLDPG GENEAETAAR
260 270 280 290 300
QPLIGTETPE SKPGASWDLS LQERWTVFKG LLWYIIPLVL VYFAEYFINQ
310 320 330 340 350
GLFELLFFRN TSLSHAQQYR WYQMLYQAGV FASRSSLQCC RIRFTWVLAL
360 370 380 390 400
LQCLNLALLL ADVCLNFLPS IYLIFIIILY EGLLGGAAYV NTFHNIALET
410 420 430
SDKHREFAME AACISDTLGI SLSGVLALPL HDFLCHLP
Length:438
Mass (Da):47,657
Last modified:July 27, 2011 - v2
Checksum:i2A06D2CE4728C1AC
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti79 – 791P → R in AAC52957. (PubMed:8812504)Curated
Sequence conflicti120 – 1201H → Y in AAB07595. (PubMed:9151313)Curated
Sequence conflicti237 – 2371L → W in AAC52957. (PubMed:8812504)Curated
Sequence conflicti317 – 3182QQ → HE in AAC52957. (PubMed:8812504)Curated
Sequence conflicti380 – 3801Y → H in AAC52957. (PubMed:8812504)Curated

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U47106 mRNA. Translation: AAC52957.1.
U68064 mRNA. Translation: AAB07595.1.
U92811 mRNA. Translation: AAB69983.1.
BC058753 mRNA. Translation: AAH58753.1.
BC080759 mRNA. Translation: AAH80759.1.
CCDSiCCDS21833.1.
RefSeqiNP_001139783.1. NM_001146311.1.
NP_034037.3. NM_009907.3.
XP_006507351.1. XM_006507288.1.
XP_006507352.1. XM_006507289.1.
XP_006507353.1. XM_006507290.1.
XP_006507354.1. XM_006507291.1.
XP_006507355.1. XM_006507292.1.
XP_006507356.1. XM_006507293.1.
XP_006507357.1. XM_006507294.1.
XP_006507358.1. XM_006507295.1.
UniGeneiMm.268930.

Genome annotation databases

EnsembliENSMUST00000032962; ENSMUSP00000032962; ENSMUSG00000030720.
ENSMUST00000084589; ENSMUSP00000081636; ENSMUSG00000030720.
ENSMUST00000116269; ENSMUSP00000111973; ENSMUSG00000030720.
GeneIDi12752.
KEGGimmu:12752.
UCSCiuc009jrx.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U47106 mRNA. Translation: AAC52957.1 .
U68064 mRNA. Translation: AAB07595.1 .
U92811 mRNA. Translation: AAB69983.1 .
BC058753 mRNA. Translation: AAH58753.1 .
BC080759 mRNA. Translation: AAH80759.1 .
CCDSi CCDS21833.1.
RefSeqi NP_001139783.1. NM_001146311.1.
NP_034037.3. NM_009907.3.
XP_006507351.1. XM_006507288.1.
XP_006507352.1. XM_006507289.1.
XP_006507353.1. XM_006507290.1.
XP_006507354.1. XM_006507291.1.
XP_006507355.1. XM_006507292.1.
XP_006507356.1. XM_006507293.1.
XP_006507357.1. XM_006507294.1.
XP_006507358.1. XM_006507295.1.
UniGenei Mm.268930.

3D structure databases

ProteinModelPortali Q61124.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 10090.ENSMUSP00000081636.

Protein family/group databases

TCDBi 2.A.57.5.1. the equilibrative nucleoside transporter (ent) family.

PTM databases

PhosphoSitei Q61124.

Proteomic databases

MaxQBi Q61124.
PRIDEi Q61124.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000032962 ; ENSMUSP00000032962 ; ENSMUSG00000030720 .
ENSMUST00000084589 ; ENSMUSP00000081636 ; ENSMUSG00000030720 .
ENSMUST00000116269 ; ENSMUSP00000111973 ; ENSMUSG00000030720 .
GeneIDi 12752.
KEGGi mmu:12752.
UCSCi uc009jrx.2. mouse.

Organism-specific databases

CTDi 1201.
MGIi MGI:107537. Cln3.

Phylogenomic databases

eggNOGi NOG325947.
GeneTreei ENSGT00390000003249.
HOGENOMi HOG000164765.
HOVERGENi HBG017297.
InParanoidi Q61124.
KOi K12389.
OMAi NYGYVVM.
OrthoDBi EOG7N8ZZQ.
TreeFami TF314055.

Miscellaneous databases

NextBioi 282088.
PROi Q61124.
SOURCEi Search...

Gene expression databases

Bgeei Q61124.
ExpressionAtlasi Q61124. baseline and differential.
Genevestigatori Q61124.

Family and domain databases

InterProi IPR003492. Battenin_disease_Cln3.
IPR018460. Battenin_disease_Cln3_subgr.
IPR016196. MFS_dom_general_subst_transpt.
[Graphical view ]
PANTHERi PTHR10981. PTHR10981. 1 hit.
Pfami PF02487. CLN3. 1 hit.
[Graphical view ]
PIRSFi PIRSF015974. CLN3_BTN1. 1 hit.
PRINTSi PR01315. BATTENIN.
SUPFAMi SSF103473. SSF103473. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Isolation and chromosomal mapping of a mouse homolog of the Batten disease gene CLN3."
    Lee R.L., Johnson K.R., Lerner T.J.
    Genomics 35:617-619(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Teratocarcinoma.
  2. "Cross-species homology of the CLN3 gene."
    Taschner P.E.M., de Vos N., Breuning M.H.
    Neuropediatrics 28:18-20(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: BALB/c.
    Tissue: Liver.
  3. "Immunochemical localization of the Batten disease (CLN3) protein in retina."
    Katz M.L., Gao C.-L., Prabhakaram M., Shibuya H., Liu P.-C., Johnson G.S.
    Submitted (MAR-1997) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: C57BL/6.
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: FVB/N.
    Tissue: Colon and Mammary tumor.
  5. "The phagosomal proteome in interferon-gamma-activated macrophages."
    Trost M., English L., Lemieux S., Courcelles M., Desjardins M., Thibault P.
    Immunity 30:143-154(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-14, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiCLN3_MOUSE
AccessioniPrimary (citable) accession number: Q61124
Secondary accession number(s): O35934, P70400
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: July 27, 2011
Last modified: October 29, 2014
This is version 105 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3