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Protein

Battenin

Gene

Cln3

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Involved in microtubule-dependent, anterograde transport of late endosomes and lysosomes.By similarity

GO - Molecular functioni

  • calcium-dependent protein binding Source: MGI

GO - Biological processi

  • actin cytoskeleton organization Source: MGI
  • action potential Source: MGI
  • amino acid transport Source: MGI
  • amyloid precursor protein catabolic process Source: UniProtKB
  • arginine transport Source: UniProtKB
  • associative learning Source: MGI
  • autophagosome maturation Source: MGI
  • cell migration Source: MGI
  • cellular amino acid metabolic process Source: MGI
  • ceramide metabolic process Source: UniProtKB
  • endocytosis Source: MGI
  • galactosylceramide metabolic process Source: UniProtKB
  • globoside metabolic process Source: UniProtKB
  • glucosylceramide metabolic process Source: UniProtKB
  • ionotropic glutamate receptor signaling pathway Source: MGI
  • lysosomal lumen acidification Source: UniProtKB
  • lysosomal lumen pH elevation Source: UniProtKB
  • lysosome organization Source: MGI
  • macroautophagy Source: MGI
  • membrane organization Source: MGI
  • negative regulation of apoptotic process Source: UniProtKB
  • negative regulation of catalytic activity Source: MGI
  • negative regulation of macroautophagy Source: MGI
  • negative regulation of neuron apoptotic process Source: MGI
  • negative regulation of proteolysis Source: MGI
  • neuromuscular process controlling balance Source: MGI
  • neurotransmitter metabolic process Source: MGI
  • positive regulation of protein phosphorylation Source: MGI
  • protein localization to membrane Source: MGI
  • protein localization to plasma membrane Source: MGI
  • protein processing Source: MGI
  • receptor-mediated endocytosis Source: UniProtKB
  • regulation of cytosolic calcium ion concentration Source: MGI
  • regulation of filopodium assembly Source: MGI
  • regulation of gene expression Source: MGI
  • sphingomyelin metabolic process Source: UniProtKB
  • vacuolar transport Source: GO_Central
  • vesicle transport along microtubule Source: UniProtKB
Complete GO annotation...

Keywords - Biological processi

Transport

Protein family/group databases

TCDBi2.A.57.5.1. the equilibrative nucleoside transporter (ent) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Battenin
Alternative name(s):
Protein CLN3
Gene namesi
Name:Cln3
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 7

Organism-specific databases

MGIiMGI:107537. Cln3.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 37CytoplasmicSequence analysisAdd BLAST37
Transmembranei38 – 58HelicalSequence analysisAdd BLAST21
Topological domaini59 – 127LumenalSequence analysisAdd BLAST69
Transmembranei128 – 148HelicalSequence analysisAdd BLAST21
Topological domaini149 – 151CytoplasmicSequence analysis3
Transmembranei152 – 172HelicalSequence analysisAdd BLAST21
Topological domaini173 – 182LumenalSequence analysis10
Transmembranei183 – 203HelicalSequence analysisAdd BLAST21
Topological domaini204 – 277CytoplasmicSequence analysisAdd BLAST74
Transmembranei278 – 298HelicalSequence analysisAdd BLAST21
Topological domaini299 – 346LumenalSequence analysisAdd BLAST48
Transmembranei347 – 367HelicalSequence analysisAdd BLAST21
Topological domaini368 – 438CytoplasmicSequence analysisAdd BLAST71

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Endosome, Lysosome, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000898591 – 435BatteninAdd BLAST435
PropeptideiPRO_0000422292436 – 438Removed in mature formBy similarity3

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei14PhosphoserineCombined sources1
Glycosylationi71N-linked (GlcNAc...)Sequence analysis1
Glycosylationi85N-linked (GlcNAc...)Sequence analysis1
Glycosylationi310N-linked (GlcNAc...)Sequence analysis1
Modified residuei435Cysteine methyl esterBy similarity1
Lipidationi435S-farnesyl cysteineBy similarity1

Post-translational modificationi

Highly glycosylated.By similarity
Farnesylation is important for trafficking to lysosomes.By similarity

Keywords - PTMi

Glycoprotein, Lipoprotein, Methylation, Phosphoprotein, Prenylation

Proteomic databases

MaxQBiQ61124.
PaxDbiQ61124.
PeptideAtlasiQ61124.
PRIDEiQ61124.

PTM databases

iPTMnetiQ61124.
PhosphoSitePlusiQ61124.

Expressioni

Gene expression databases

BgeeiENSMUSG00000030720.
ExpressionAtlasiQ61124. baseline and differential.
GenevisibleiQ61124. MM.

Interactioni

Subunit structurei

Interacts with DCTN1, KIF3A, RAB7A and RILP (By similarity). Interacts with CLN5 (PubMed:19941651).By similarity1 Publication

GO - Molecular functioni

  • calcium-dependent protein binding Source: MGI

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000032962.

Structurei

3D structure databases

ProteinModelPortaliQ61124.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the battenin family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3880. Eukaryota.
ENOG410XT4Z. LUCA.
GeneTreeiENSGT00390000003249.
HOGENOMiHOG000164765.
HOVERGENiHBG017297.
InParanoidiQ61124.
KOiK12389.
OMAiIMLIFPA.
OrthoDBiEOG091G07YG.
TreeFamiTF314055.

Family and domain databases

InterProiIPR003492. Battenin_disease_Cln3.
IPR018460. Battenin_disease_Cln3_subgr.
IPR020846. MFS_dom.
[Graphical view]
PANTHERiPTHR10981. PTHR10981. 2 hits.
PfamiPF02487. CLN3. 1 hit.
[Graphical view]
PIRSFiPIRSF015974. CLN3_BTN1. 1 hit.
PRINTSiPR01315. BATTENIN.
SUPFAMiSSF103473. SSF103473. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q61124-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGSSAGSWRR LEDSEREETD SEPQAPRLDS RSVLWKNAVG FWILGLCNNF
60 70 80 90 100
SYVVMLSAAH DILKQEQASG NQSHVEPGPT PTPHNSSSRF DCNSISTAAV
110 120 130 140 150
LLADILPTLV IKLLAPLGLH LLPYSPRVLV SGVCSAGSFV LVAFSQSVGL
160 170 180 190 200
SLCGVVLASI SSGLGEVTFL SLTAFYPSAV ISWWSSGTGG AGLLGSLSYL
210 220 230 240 250
GLTQAGLSPQ HTLLSMLGIP VLLLASYFLL LTSPEPLDPG GENEAETAAR
260 270 280 290 300
QPLIGTETPE SKPGASWDLS LQERWTVFKG LLWYIIPLVL VYFAEYFINQ
310 320 330 340 350
GLFELLFFRN TSLSHAQQYR WYQMLYQAGV FASRSSLQCC RIRFTWVLAL
360 370 380 390 400
LQCLNLALLL ADVCLNFLPS IYLIFIIILY EGLLGGAAYV NTFHNIALET
410 420 430
SDKHREFAME AACISDTLGI SLSGVLALPL HDFLCHLP
Length:438
Mass (Da):47,657
Last modified:July 27, 2011 - v2
Checksum:i2A06D2CE4728C1AC
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti79P → R in AAC52957 (PubMed:8812504).Curated1
Sequence conflicti120H → Y in AAB07595 (PubMed:9151313).Curated1
Sequence conflicti237L → W in AAC52957 (PubMed:8812504).Curated1
Sequence conflicti317 – 318QQ → HE in AAC52957 (PubMed:8812504).Curated2
Sequence conflicti380Y → H in AAC52957 (PubMed:8812504).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U47106 mRNA. Translation: AAC52957.1.
U68064 mRNA. Translation: AAB07595.1.
U92811 mRNA. Translation: AAB69983.1.
BC058753 mRNA. Translation: AAH58753.1.
BC080759 mRNA. Translation: AAH80759.1.
CCDSiCCDS21833.1.
RefSeqiNP_001139783.1. NM_001146311.2.
NP_034037.3. NM_009907.4.
XP_006507351.1. XM_006507288.3.
XP_006507352.1. XM_006507289.2.
XP_006507353.1. XM_006507290.1.
XP_006507355.1. XM_006507292.1.
XP_006507356.1. XM_006507293.3.
XP_017177452.1. XM_017321963.1.
UniGeneiMm.268930.

Genome annotation databases

EnsembliENSMUST00000032962; ENSMUSP00000032962; ENSMUSG00000030720.
ENSMUST00000084589; ENSMUSP00000081636; ENSMUSG00000030720.
ENSMUST00000116269; ENSMUSP00000111973; ENSMUSG00000030720.
GeneIDi12752.
KEGGimmu:12752.
UCSCiuc009jrx.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U47106 mRNA. Translation: AAC52957.1.
U68064 mRNA. Translation: AAB07595.1.
U92811 mRNA. Translation: AAB69983.1.
BC058753 mRNA. Translation: AAH58753.1.
BC080759 mRNA. Translation: AAH80759.1.
CCDSiCCDS21833.1.
RefSeqiNP_001139783.1. NM_001146311.2.
NP_034037.3. NM_009907.4.
XP_006507351.1. XM_006507288.3.
XP_006507352.1. XM_006507289.2.
XP_006507353.1. XM_006507290.1.
XP_006507355.1. XM_006507292.1.
XP_006507356.1. XM_006507293.3.
XP_017177452.1. XM_017321963.1.
UniGeneiMm.268930.

3D structure databases

ProteinModelPortaliQ61124.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000032962.

Protein family/group databases

TCDBi2.A.57.5.1. the equilibrative nucleoside transporter (ent) family.

PTM databases

iPTMnetiQ61124.
PhosphoSitePlusiQ61124.

Proteomic databases

MaxQBiQ61124.
PaxDbiQ61124.
PeptideAtlasiQ61124.
PRIDEiQ61124.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000032962; ENSMUSP00000032962; ENSMUSG00000030720.
ENSMUST00000084589; ENSMUSP00000081636; ENSMUSG00000030720.
ENSMUST00000116269; ENSMUSP00000111973; ENSMUSG00000030720.
GeneIDi12752.
KEGGimmu:12752.
UCSCiuc009jrx.2. mouse.

Organism-specific databases

CTDi1201.
MGIiMGI:107537. Cln3.

Phylogenomic databases

eggNOGiKOG3880. Eukaryota.
ENOG410XT4Z. LUCA.
GeneTreeiENSGT00390000003249.
HOGENOMiHOG000164765.
HOVERGENiHBG017297.
InParanoidiQ61124.
KOiK12389.
OMAiIMLIFPA.
OrthoDBiEOG091G07YG.
TreeFamiTF314055.

Miscellaneous databases

PROiQ61124.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000030720.
ExpressionAtlasiQ61124. baseline and differential.
GenevisibleiQ61124. MM.

Family and domain databases

InterProiIPR003492. Battenin_disease_Cln3.
IPR018460. Battenin_disease_Cln3_subgr.
IPR020846. MFS_dom.
[Graphical view]
PANTHERiPTHR10981. PTHR10981. 2 hits.
PfamiPF02487. CLN3. 1 hit.
[Graphical view]
PIRSFiPIRSF015974. CLN3_BTN1. 1 hit.
PRINTSiPR01315. BATTENIN.
SUPFAMiSSF103473. SSF103473. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiCLN3_MOUSE
AccessioniPrimary (citable) accession number: Q61124
Secondary accession number(s): O35934, P70400
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: July 27, 2011
Last modified: November 2, 2016
This is version 122 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.