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Protein

Probable G-protein coupled receptor 19

Gene

Gpr19

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Orphan receptor.

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Names & Taxonomyi

Protein namesi
Recommended name:
Probable G-protein coupled receptor 19
Gene namesi
Name:Gpr19
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589 Componenti: Chromosome 6

Organism-specific databases

MGIiMGI:892973. Gpr19.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 6969ExtracellularSequence AnalysisAdd
BLAST
Transmembranei70 – 9021Helical; Name=1Add
BLAST
Topological domaini91 – 10212CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei103 – 12321Helical; Name=2Add
BLAST
Topological domaini124 – 15229ExtracellularSequence AnalysisAdd
BLAST
Transmembranei153 – 17321Helical; Name=3Add
BLAST
Topological domaini174 – 1829CytoplasmicSequence Analysis
Transmembranei183 – 20321Helical; Name=4Add
BLAST
Topological domaini204 – 22118ExtracellularSequence AnalysisAdd
BLAST
Transmembranei222 – 24221Helical; Name=5Add
BLAST
Topological domaini243 – 27735CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei278 – 29821Helical; Name=6Add
BLAST
Topological domaini299 – 30911ExtracellularSequence AnalysisAdd
BLAST
Transmembranei310 – 33223Helical; Name=7Add
BLAST
Topological domaini333 – 41583CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 415415Probable G-protein coupled receptor 19PRO_0000069539Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi25 – 251N-linked (GlcNAc...)Sequence Analysis
Glycosylationi52 – 521N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi138 ↔ 210PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PRIDEiQ61121.

PTM databases

PhosphoSiteiQ61121.

Expressioni

Gene expression databases

BgeeiQ61121.
CleanExiMM_GPR19.
GenevisibleiQ61121. MM.

Structurei

3D structure databases

ProteinModelPortaliQ61121.
SMRiQ61121. Positions 64-342.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG318116.
GeneTreeiENSGT00780000121924.
HOGENOMiHOG000112786.
HOVERGENiHBG051799.
InParanoidiQ61121.
KOiK04316.
OMAiQLWHPHE.
OrthoDBiEOG7SXW36.
PhylomeDBiQ61121.
TreeFamiTF331630.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PROSITEiPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q61121-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MVFAHRMDND QPPVVTATLL VPLQNSSCAE AAEALLPHGL MGLHEEHSWM
60 70 80 90 100
SNRTELQYEL NPGEVATASI FFGALWLFSI FGNSLVCLVI HRSRRTQSTT
110 120 130 140 150
NYFVVSMACA DLLISVASTP FVVLQFTTGR WTLGSAMCKV VRYFQYLTPG
160 170 180 190 200
VQIYVLLSIC IDRFYTIVYP LSFKVSREKA KKMIAASWIL DAAFVTPVFF
210 220 230 240 250
FYGSNWDSHC NYFLPPSWEG TAYTVIHFLV GFVIPSILII LFYQKVIKYI
260 270 280 290 300
WRIGTDGRTL RRTMNIVPRT KVKTVKMFLL LNLVFLFSWL PFHVAQLWHP
310 320 330 340 350
HEQDYKKSSL VFTAVTWVSF SSSASKPTLY SIYNANFRRG MKETFCMSSM
360 370 380 390 400
KCYRSNAYTI TTSSRMAKRN YVGISEIPPV SRTITKDSIY DSFDREAREK
410
KLAWPINSNP PNTFV
Length:415
Mass (Da):47,533
Last modified:December 6, 2005 - v2
Checksum:i1904B2043DBF72D1
GO
Isoform 2 (identifier: Q61121-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-6: Missing.

Show »
Length:409
Mass (Da):46,791
Checksum:iEE45E377AAEF7766
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti26 – 261S → G in AAA93354 (Ref. 1) Curated
Sequence conflicti304 – 3041D → G in AAH50187 (PubMed:15489334).Curated
Sequence conflicti323 – 3231S → P in AAH50187 (PubMed:15489334).Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 66Missing in isoform 2. 3 PublicationsVSP_016527

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U46923 mRNA. Translation: AAA93354.1.
AK132917 mRNA. Translation: BAE21421.1.
AK140770 mRNA. Translation: BAE24474.1.
BC021648 mRNA. Translation: AAH21648.1.
BC050187 mRNA. Translation: AAH50187.1.
CCDSiCCDS20641.1. [Q61121-2]
CCDS51937.1. [Q61121-1]
RefSeqiNP_001161166.1. NM_001167694.2. [Q61121-1]
NP_001161167.1. NM_001167695.2. [Q61121-2]
NP_001161168.1. NM_001167696.2. [Q61121-2]
NP_001161169.1. NM_001167697.2. [Q61121-1]
NP_001161171.1. NM_001167699.2. [Q61121-1]
NP_001161172.1. NM_001167700.2. [Q61121-2]
NP_032183.2. NM_008157.3. [Q61121-2]
XP_006505617.1. XM_006505554.1. [Q61121-2]
UniGeneiMm.4787.

Genome annotation databases

EnsembliENSMUST00000046255; ENSMUSP00000047630; ENSMUSG00000032641. [Q61121-1]
ENSMUST00000066107; ENSMUSP00000066287; ENSMUSG00000032641. [Q61121-1]
ENSMUST00000111932; ENSMUSP00000107563; ENSMUSG00000032641. [Q61121-2]
ENSMUST00000116515; ENSMUSP00000112214; ENSMUSG00000032641. [Q61121-2]
ENSMUST00000165392; ENSMUSP00000127876; ENSMUSG00000032641. [Q61121-2]
GeneIDi14760.
KEGGimmu:14760.
UCSCiuc009ekv.3. mouse. [Q61121-1]
uc009eky.3. mouse. [Q61121-2]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U46923 mRNA. Translation: AAA93354.1.
AK132917 mRNA. Translation: BAE21421.1.
AK140770 mRNA. Translation: BAE24474.1.
BC021648 mRNA. Translation: AAH21648.1.
BC050187 mRNA. Translation: AAH50187.1.
CCDSiCCDS20641.1. [Q61121-2]
CCDS51937.1. [Q61121-1]
RefSeqiNP_001161166.1. NM_001167694.2. [Q61121-1]
NP_001161167.1. NM_001167695.2. [Q61121-2]
NP_001161168.1. NM_001167696.2. [Q61121-2]
NP_001161169.1. NM_001167697.2. [Q61121-1]
NP_001161171.1. NM_001167699.2. [Q61121-1]
NP_001161172.1. NM_001167700.2. [Q61121-2]
NP_032183.2. NM_008157.3. [Q61121-2]
XP_006505617.1. XM_006505554.1. [Q61121-2]
UniGeneiMm.4787.

3D structure databases

ProteinModelPortaliQ61121.
SMRiQ61121. Positions 64-342.
ModBaseiSearch...
MobiDBiSearch...

Protein family/group databases

GPCRDBiSearch...

PTM databases

PhosphoSiteiQ61121.

Proteomic databases

PRIDEiQ61121.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000046255; ENSMUSP00000047630; ENSMUSG00000032641. [Q61121-1]
ENSMUST00000066107; ENSMUSP00000066287; ENSMUSG00000032641. [Q61121-1]
ENSMUST00000111932; ENSMUSP00000107563; ENSMUSG00000032641. [Q61121-2]
ENSMUST00000116515; ENSMUSP00000112214; ENSMUSG00000032641. [Q61121-2]
ENSMUST00000165392; ENSMUSP00000127876; ENSMUSG00000032641. [Q61121-2]
GeneIDi14760.
KEGGimmu:14760.
UCSCiuc009ekv.3. mouse. [Q61121-1]
uc009eky.3. mouse. [Q61121-2]

Organism-specific databases

CTDi2842.
MGIiMGI:892973. Gpr19.

Phylogenomic databases

eggNOGiNOG318116.
GeneTreeiENSGT00780000121924.
HOGENOMiHOG000112786.
HOVERGENiHBG051799.
InParanoidiQ61121.
KOiK04316.
OMAiQLWHPHE.
OrthoDBiEOG7SXW36.
PhylomeDBiQ61121.
TreeFamiTF331630.

Miscellaneous databases

NextBioi286831.
PROiQ61121.
SOURCEiSearch...

Gene expression databases

BgeeiQ61121.
CleanExiMM_GPR19.
GenevisibleiQ61121. MM.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PROSITEiPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Bonner T.I., Matsuda L.A.
    Submitted (APR-1996) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
  2. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Strain: C57BL/6J.
    Tissue: Head and Testis.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
    Strain: C57BL/6J and Czech II.
    Tissue: Embryo and Mammary tumor.

Entry informationi

Entry nameiGPR19_MOUSE
AccessioniPrimary (citable) accession number: Q61121
Secondary accession number(s): Q810I4, Q8VDJ9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: December 6, 2005
Last modified: July 22, 2015
This is version 120 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.