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Q61121 (GPR19_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 111. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Probable G-protein coupled receptor 19
Gene names
Name:Gpr19
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length415 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Orphan receptor.

Subcellular location

Cell membrane; Multi-pass membrane protein.

Sequence similarities

Belongs to the G-protein coupled receptor 1 family.

Ontologies

Keywords
   Cellular componentCell membrane
Membrane
   Coding sequence diversityAlternative splicing
   DomainTransmembrane
Transmembrane helix
   Molecular functionG-protein coupled receptor
Receptor
Transducer
   PTMDisulfide bond
Glycoprotein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Cellular_componentintegral component of membrane

Inferred from electronic annotation. Source: UniProtKB-KW

plasma membrane

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionG-protein coupled receptor activity

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: Q61121-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: Q61121-2)

The sequence of this isoform differs from the canonical sequence as follows:
     1-6: Missing.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 415415Probable G-protein coupled receptor 19
PRO_0000069539

Regions

Topological domain1 – 6969Extracellular Potential
Transmembrane70 – 9021Helical; Name=1
Topological domain91 – 10212Cytoplasmic Potential
Transmembrane103 – 12321Helical; Name=2
Topological domain124 – 15229Extracellular Potential
Transmembrane153 – 17321Helical; Name=3
Topological domain174 – 1829Cytoplasmic Potential
Transmembrane183 – 20321Helical; Name=4
Topological domain204 – 22118Extracellular Potential
Transmembrane222 – 24221Helical; Name=5
Topological domain243 – 27735Cytoplasmic Potential
Transmembrane278 – 29821Helical; Name=6
Topological domain299 – 30911Extracellular Potential
Transmembrane310 – 33223Helical; Name=7
Topological domain333 – 41583Cytoplasmic Potential

Amino acid modifications

Glycosylation251N-linked (GlcNAc...) Potential
Glycosylation521N-linked (GlcNAc...) Potential
Disulfide bond138 ↔ 210 By similarity

Natural variations

Alternative sequence1 – 66Missing in isoform 2.
VSP_016527

Experimental info

Sequence conflict261S → G in AAA93354. Ref.1
Sequence conflict3041D → G in AAH50187. Ref.3
Sequence conflict3231S → P in AAH50187. Ref.3

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified December 6, 2005. Version 2.
Checksum: 1904B2043DBF72D1

FASTA41547,533
        10         20         30         40         50         60 
MVFAHRMDND QPPVVTATLL VPLQNSSCAE AAEALLPHGL MGLHEEHSWM SNRTELQYEL 

        70         80         90        100        110        120 
NPGEVATASI FFGALWLFSI FGNSLVCLVI HRSRRTQSTT NYFVVSMACA DLLISVASTP 

       130        140        150        160        170        180 
FVVLQFTTGR WTLGSAMCKV VRYFQYLTPG VQIYVLLSIC IDRFYTIVYP LSFKVSREKA 

       190        200        210        220        230        240 
KKMIAASWIL DAAFVTPVFF FYGSNWDSHC NYFLPPSWEG TAYTVIHFLV GFVIPSILII 

       250        260        270        280        290        300 
LFYQKVIKYI WRIGTDGRTL RRTMNIVPRT KVKTVKMFLL LNLVFLFSWL PFHVAQLWHP 

       310        320        330        340        350        360 
HEQDYKKSSL VFTAVTWVSF SSSASKPTLY SIYNANFRRG MKETFCMSSM KCYRSNAYTI 

       370        380        390        400        410 
TTSSRMAKRN YVGISEIPPV SRTITKDSIY DSFDREAREK KLAWPINSNP PNTFV 

« Hide

Isoform 2 [UniParc].

Checksum: EE45E377AAEF7766
Show »

FASTA40946,791

References

« Hide 'large scale' references
[1]Bonner T.I., Matsuda L.A.
Submitted (APR-1996) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
[2]"The transcriptional landscape of the mammalian genome."
Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. expand/collapse author list , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
Strain: C57BL/6J.
Tissue: Head and Testis.
[3]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
Strain: C57BL/6J and Czech II.
Tissue: Embryo and Mammary tumor.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
U46923 mRNA. Translation: AAA93354.1.
AK132917 mRNA. Translation: BAE21421.1.
AK140770 mRNA. Translation: BAE24474.1.
BC021648 mRNA. Translation: AAH21648.1.
BC050187 mRNA. Translation: AAH50187.1.
CCDSCCDS20641.1. [Q61121-2]
CCDS51937.1. [Q61121-1]
RefSeqNP_001161166.1. NM_001167694.2. [Q61121-1]
NP_001161167.1. NM_001167695.2. [Q61121-2]
NP_001161168.1. NM_001167696.2. [Q61121-2]
NP_001161169.1. NM_001167697.2. [Q61121-1]
NP_001161171.1. NM_001167699.2. [Q61121-1]
NP_001161172.1. NM_001167700.2. [Q61121-2]
NP_032183.2. NM_008157.3. [Q61121-2]
XP_006505617.1. XM_006505554.1. [Q61121-2]
UniGeneMm.4787.

3D structure databases

ProteinModelPortalQ61121.
SMRQ61121. Positions 64-342.
ModBaseSearch...
MobiDBSearch...

Protein family/group databases

GPCRDBSearch...

PTM databases

PhosphoSiteQ61121.

Proteomic databases

PRIDEQ61121.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000046255; ENSMUSP00000047630; ENSMUSG00000032641. [Q61121-1]
ENSMUST00000066107; ENSMUSP00000066287; ENSMUSG00000032641. [Q61121-1]
ENSMUST00000111932; ENSMUSP00000107563; ENSMUSG00000032641. [Q61121-2]
ENSMUST00000116515; ENSMUSP00000112214; ENSMUSG00000032641. [Q61121-2]
ENSMUST00000165392; ENSMUSP00000127876; ENSMUSG00000032641. [Q61121-2]
GeneID14760.
KEGGmmu:14760.
UCSCuc009ekv.2. mouse. [Q61121-1]

Organism-specific databases

CTD2842.
MGIMGI:892973. Gpr19.

Phylogenomic databases

eggNOGNOG318116.
GeneTreeENSGT00730000110635.
HOGENOMHOG000112786.
HOVERGENHBG051799.
InParanoidQ61121.
KOK04316.
OMAQLWHPHE.
OrthoDBEOG7SXW36.
PhylomeDBQ61121.
TreeFamTF331630.

Gene expression databases

BgeeQ61121.
CleanExMM_GPR19.
GenevestigatorQ61121.

Family and domain databases

Gene3D1.20.1070.10. 1 hit.
InterProIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PfamPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSPR00237. GPCRRHODOPSN.
PROSITEPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio286831.
PROQ61121.
SOURCESearch...

Entry information

Entry nameGPR19_MOUSE
AccessionPrimary (citable) accession number: Q61121
Secondary accession number(s): Q810I4, Q8VDJ9
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: December 6, 2005
Last modified: July 9, 2014
This is version 111 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

7-transmembrane G-linked receptors

List of 7-transmembrane G-linked receptor entries