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Q61121

- GPR19_MOUSE

UniProt

Q61121 - GPR19_MOUSE

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Protein
Probable G-protein coupled receptor 19
Gene
Gpr19
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

Orphan receptor.

GO - Molecular functioni

  1. G-protein coupled receptor activity Source: UniProtKB-KW
Complete GO annotation...

GO - Biological processi

    Complete GO annotation...

    Keywords - Molecular functioni

    G-protein coupled receptor, Receptor, Transducer

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Probable G-protein coupled receptor 19
    Gene namesi
    Name:Gpr19
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 6

    Organism-specific databases

    MGIiMGI:892973. Gpr19.

    Subcellular locationi

    Topology

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 6969Extracellular Reviewed prediction
    Add
    BLAST
    Transmembranei70 – 9021Helical; Name=1
    Add
    BLAST
    Topological domaini91 – 10212Cytoplasmic Reviewed prediction
    Add
    BLAST
    Transmembranei103 – 12321Helical; Name=2
    Add
    BLAST
    Topological domaini124 – 15229Extracellular Reviewed prediction
    Add
    BLAST
    Transmembranei153 – 17321Helical; Name=3
    Add
    BLAST
    Topological domaini174 – 1829Cytoplasmic Reviewed prediction
    Transmembranei183 – 20321Helical; Name=4
    Add
    BLAST
    Topological domaini204 – 22118Extracellular Reviewed prediction
    Add
    BLAST
    Transmembranei222 – 24221Helical; Name=5
    Add
    BLAST
    Topological domaini243 – 27735Cytoplasmic Reviewed prediction
    Add
    BLAST
    Transmembranei278 – 29821Helical; Name=6
    Add
    BLAST
    Topological domaini299 – 30911Extracellular Reviewed prediction
    Add
    BLAST
    Transmembranei310 – 33223Helical; Name=7
    Add
    BLAST
    Topological domaini333 – 41583Cytoplasmic Reviewed prediction
    Add
    BLAST

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. plasma membrane Source: UniProtKB-SubCell
    Complete GO annotation...

    Keywords - Cellular componenti

    Cell membrane, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 415415Probable G-protein coupled receptor 19
    PRO_0000069539Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi25 – 251N-linked (GlcNAc...) Reviewed prediction
    Glycosylationi52 – 521N-linked (GlcNAc...) Reviewed prediction
    Disulfide bondi138 ↔ 210 By similarity

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    PRIDEiQ61121.

    PTM databases

    PhosphoSiteiQ61121.

    Expressioni

    Gene expression databases

    BgeeiQ61121.
    CleanExiMM_GPR19.
    GenevestigatoriQ61121.

    Structurei

    3D structure databases

    ProteinModelPortaliQ61121.
    SMRiQ61121. Positions 64-342.

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG318116.
    GeneTreeiENSGT00730000110635.
    HOGENOMiHOG000112786.
    HOVERGENiHBG051799.
    InParanoidiQ61121.
    KOiK04316.
    OMAiQLWHPHE.
    OrthoDBiEOG7SXW36.
    PhylomeDBiQ61121.
    TreeFamiTF331630.

    Family and domain databases

    Gene3Di1.20.1070.10. 1 hit.
    InterProiIPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    [Graphical view]
    PfamiPF00001. 7tm_1. 1 hit.
    [Graphical view]
    PRINTSiPR00237. GPCRRHODOPSN.
    PROSITEiPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q61121-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MVFAHRMDND QPPVVTATLL VPLQNSSCAE AAEALLPHGL MGLHEEHSWM    50
    SNRTELQYEL NPGEVATASI FFGALWLFSI FGNSLVCLVI HRSRRTQSTT 100
    NYFVVSMACA DLLISVASTP FVVLQFTTGR WTLGSAMCKV VRYFQYLTPG 150
    VQIYVLLSIC IDRFYTIVYP LSFKVSREKA KKMIAASWIL DAAFVTPVFF 200
    FYGSNWDSHC NYFLPPSWEG TAYTVIHFLV GFVIPSILII LFYQKVIKYI 250
    WRIGTDGRTL RRTMNIVPRT KVKTVKMFLL LNLVFLFSWL PFHVAQLWHP 300
    HEQDYKKSSL VFTAVTWVSF SSSASKPTLY SIYNANFRRG MKETFCMSSM 350
    KCYRSNAYTI TTSSRMAKRN YVGISEIPPV SRTITKDSIY DSFDREAREK 400
    KLAWPINSNP PNTFV 415
    Length:415
    Mass (Da):47,533
    Last modified:December 6, 2005 - v2
    Checksum:i1904B2043DBF72D1
    GO
    Isoform 2 (identifier: Q61121-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-6: Missing.

    Show »
    Length:409
    Mass (Da):46,791
    Checksum:iEE45E377AAEF7766
    GO

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 66Missing in isoform 2.
    VSP_016527

    Sequence conflict

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti26 – 261S → G in AAA93354. 1 Publication
    Sequence conflicti304 – 3041D → G in AAH50187. 1 Publication
    Sequence conflicti323 – 3231S → P in AAH50187. 1 Publication

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U46923 mRNA. Translation: AAA93354.1.
    AK132917 mRNA. Translation: BAE21421.1.
    AK140770 mRNA. Translation: BAE24474.1.
    BC021648 mRNA. Translation: AAH21648.1.
    BC050187 mRNA. Translation: AAH50187.1.
    CCDSiCCDS20641.1. [Q61121-2]
    CCDS51937.1. [Q61121-1]
    RefSeqiNP_001161166.1. NM_001167694.2. [Q61121-1]
    NP_001161167.1. NM_001167695.2. [Q61121-2]
    NP_001161168.1. NM_001167696.2. [Q61121-2]
    NP_001161169.1. NM_001167697.2. [Q61121-1]
    NP_001161171.1. NM_001167699.2. [Q61121-1]
    NP_001161172.1. NM_001167700.2. [Q61121-2]
    NP_032183.2. NM_008157.3. [Q61121-2]
    XP_006505617.1. XM_006505554.1. [Q61121-2]
    UniGeneiMm.4787.

    Genome annotation databases

    EnsembliENSMUST00000046255; ENSMUSP00000047630; ENSMUSG00000032641. [Q61121-1]
    ENSMUST00000066107; ENSMUSP00000066287; ENSMUSG00000032641. [Q61121-1]
    ENSMUST00000111932; ENSMUSP00000107563; ENSMUSG00000032641. [Q61121-2]
    ENSMUST00000116515; ENSMUSP00000112214; ENSMUSG00000032641. [Q61121-2]
    ENSMUST00000165392; ENSMUSP00000127876; ENSMUSG00000032641. [Q61121-2]
    GeneIDi14760.
    KEGGimmu:14760.
    UCSCiuc009ekv.2. mouse. [Q61121-1]

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U46923 mRNA. Translation: AAA93354.1 .
    AK132917 mRNA. Translation: BAE21421.1 .
    AK140770 mRNA. Translation: BAE24474.1 .
    BC021648 mRNA. Translation: AAH21648.1 .
    BC050187 mRNA. Translation: AAH50187.1 .
    CCDSi CCDS20641.1. [Q61121-2 ]
    CCDS51937.1. [Q61121-1 ]
    RefSeqi NP_001161166.1. NM_001167694.2. [Q61121-1 ]
    NP_001161167.1. NM_001167695.2. [Q61121-2 ]
    NP_001161168.1. NM_001167696.2. [Q61121-2 ]
    NP_001161169.1. NM_001167697.2. [Q61121-1 ]
    NP_001161171.1. NM_001167699.2. [Q61121-1 ]
    NP_001161172.1. NM_001167700.2. [Q61121-2 ]
    NP_032183.2. NM_008157.3. [Q61121-2 ]
    XP_006505617.1. XM_006505554.1. [Q61121-2 ]
    UniGenei Mm.4787.

    3D structure databases

    ProteinModelPortali Q61121.
    SMRi Q61121. Positions 64-342.
    ModBasei Search...

    Protein family/group databases

    GPCRDBi Search...

    PTM databases

    PhosphoSitei Q61121.

    Proteomic databases

    PRIDEi Q61121.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000046255 ; ENSMUSP00000047630 ; ENSMUSG00000032641 . [Q61121-1 ]
    ENSMUST00000066107 ; ENSMUSP00000066287 ; ENSMUSG00000032641 . [Q61121-1 ]
    ENSMUST00000111932 ; ENSMUSP00000107563 ; ENSMUSG00000032641 . [Q61121-2 ]
    ENSMUST00000116515 ; ENSMUSP00000112214 ; ENSMUSG00000032641 . [Q61121-2 ]
    ENSMUST00000165392 ; ENSMUSP00000127876 ; ENSMUSG00000032641 . [Q61121-2 ]
    GeneIDi 14760.
    KEGGi mmu:14760.
    UCSCi uc009ekv.2. mouse. [Q61121-1 ]

    Organism-specific databases

    CTDi 2842.
    MGIi MGI:892973. Gpr19.

    Phylogenomic databases

    eggNOGi NOG318116.
    GeneTreei ENSGT00730000110635.
    HOGENOMi HOG000112786.
    HOVERGENi HBG051799.
    InParanoidi Q61121.
    KOi K04316.
    OMAi QLWHPHE.
    OrthoDBi EOG7SXW36.
    PhylomeDBi Q61121.
    TreeFami TF331630.

    Miscellaneous databases

    NextBioi 286831.
    PROi Q61121.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q61121.
    CleanExi MM_GPR19.
    Genevestigatori Q61121.

    Family and domain databases

    Gene3Di 1.20.1070.10. 1 hit.
    InterProi IPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    [Graphical view ]
    Pfami PF00001. 7tm_1. 1 hit.
    [Graphical view ]
    PRINTSi PR00237. GPCRRHODOPSN.
    PROSITEi PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    « Hide 'large scale' publications
    1. Bonner T.I., Matsuda L.A.
      Submitted (APR-1996) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
    2. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
      Strain: C57BL/6J.
      Tissue: Head and Testis.
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
      Strain: C57BL/6J and Czech II.
      Tissue: Embryo and Mammary tumor.

    Entry informationi

    Entry nameiGPR19_MOUSE
    AccessioniPrimary (citable) accession number: Q61121
    Secondary accession number(s): Q810I4, Q8VDJ9
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1997
    Last sequence update: December 6, 2005
    Last modified: July 9, 2014
    This is version 111 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. 7-transmembrane G-linked receptors
      List of 7-transmembrane G-linked receptor entries
    2. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3

    Similar proteinsi