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Protein

SHC-transforming protein 3

Gene

Shc3

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Signaling adapter that couples activated growth factor receptors to signaling pathway in neurons. Involved in the signal transduction pathways of neurotrophin-activated Trk receptors in cortical neurons (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

  • central nervous system development Source: InterPro
  • epidermal growth factor receptor signaling pathway Source: GO_Central
  • intracellular signal transduction Source: InterPro
  • learning or memory Source: MGI
  • synaptic transmission, glutamatergic Source: MGI
Complete GO annotation...

Enzyme and pathway databases

ReactomeiREACT_320246. Signalling to RAS.
REACT_333309. SHC-mediated signalling.
REACT_333431. Signal attenuation.

Names & Taxonomyi

Protein namesi
Recommended name:
SHC-transforming protein 3
Alternative name(s):
Neuronal Shc
Short name:
N-Shc
SHC-transforming protein C
Src homology 2 domain-containing-transforming protein C3
Short name:
SH2 domain protein C3
Gene namesi
Name:Shc3
Synonyms:Nshc, ShcC
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589 Componenti: Chromosome 13

Organism-specific databases

MGIiMGI:106179. Shc3.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 474474SHC-transforming protein 3PRO_0000097735Add
BLAST

Post-translational modificationi

Tyrosine phosphorylated.By similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ61120.
PaxDbiQ61120.
PRIDEiQ61120.

PTM databases

PhosphoSiteiQ61120.

Expressioni

Tissue specificityi

Predominantly expressed in the adult brain.

Gene expression databases

BgeeiQ61120.
GenevisibleiQ61120. MM.

Interactioni

Subunit structurei

Interacts with the Trk receptors in a phosphotyrosine-dependent manner. Once activated, binds to GRB2. Interacts with activated EGF receptors (By similarity).By similarity

Binary interactionsi

WithEntry#Exp.IntActNotes
AppP120232EBI-79107,EBI-78814

Protein-protein interaction databases

BioGridi203216. 3 interactions.
IntActiQ61120. 1 interaction.
MINTiMINT-258872.
STRINGi10090.ENSMUSP00000021898.

Structurei

3D structure databases

ProteinModelPortaliQ61120.
SMRiQ61120. Positions 16-190, 372-473.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini29 – 214186PIDPROSITE-ProRule annotationAdd
BLAST
Domaini379 – 47092SH2PROSITE-ProRule annotationAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni215 – 378164CH1Add
BLAST

Sequence similaritiesi

Contains 1 PID domain.PROSITE-ProRule annotation
Contains 1 SH2 domain.PROSITE-ProRule annotation

Keywords - Domaini

SH2 domain

Phylogenomic databases

eggNOGiNOG315087.
GeneTreeiENSGT00390000018860.
HOGENOMiHOG000231974.
HOVERGENiHBG050121.
InParanoidiQ61120.
KOiK17448.
OMAiGSDHPYY.
OrthoDBiEOG7MD4QK.
TreeFamiTF315807.

Family and domain databases

Gene3Di2.30.29.30. 1 hit.
3.30.505.10. 1 hit.
InterProiIPR011993. PH-like_dom.
IPR006019. PID_Shc-like.
IPR006020. PTB/PI_dom.
IPR000980. SH2.
IPR029593. Shc3/ShcC/N-Shc.
[Graphical view]
PANTHERiPTHR10337:SF4. PTHR10337:SF4. 1 hit.
PfamiPF00640. PID. 1 hit.
PF00017. SH2. 1 hit.
[Graphical view]
PRINTSiPR00401. SH2DOMAIN.
PR00629. SHCPIDOMAIN.
SMARTiSM00462. PTB. 1 hit.
SM00252. SH2. 1 hit.
[Graphical view]
SUPFAMiSSF55550. SSF55550. 1 hit.
PROSITEiPS01179. PID. 1 hit.
PS50001. SH2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q61120-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSATRKSRAG DEPLPRPPRG APHTSDQVLG PGVTYVVKYL GCIEVLRSMR
60 70 80 90 100
SLDFSTRTQV TREAISRVCE AVPGAKGALK KRKPPSKMLS SILGKSNLQF
110 120 130 140 150
AGMSISLTIS TASLNLRTPD SKQIIANHHM RSISFASGGD PDTTDYVAYV
160 170 180 190 200
AKDPVNRRAC HILECCDGLA QDVIGSIGQA FELRFKQYLQ CPSKVPALQD
210 220 230 240 250
RMQSLDEPWT EEEGDGPDHP YYNSVPTKMP PPGGFLDARL KGRPHAPEAA
260 270 280 290 300
QFAGKEQTYY QGRHLGDTFG EDWQRAPTRQ GSLDIYSTAE GKTHMVPVGE
310 320 330 340 350
TPTYVNTQPV PPQVWPAATS STESSPRKDL FDMKPFEDAL RNQPLGPMLS
360 370 380 390 400
KAASVECISP VTPRAPDARM LEELNAEPWY QGEMSRKEAE ALLREDGDFL
410 420 430 440 450
VRKSTTNPGS FVLTGMHNGQ AKHLLLVDPE GTIRTKDRVF DSISHLINYH
460 470
LESSLPIVSA GSELCLQQPV ERKP
Length:474
Mass (Da):52,121
Last modified:July 27, 2011 - v2
Checksum:i18550FB1C5F0F270
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti71 – 711A → R in AAC52508 (PubMed:8610109).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U46854 mRNA. Translation: AAC52508.1.
BC103612 mRNA. Translation: AAI03613.1.
BC105644 mRNA. Translation: AAI05645.1.
BC105645 mRNA. Translation: AAI05646.1.
CCDSiCCDS49265.1.
RefSeqiNP_033193.2. NM_009167.3.
UniGeneiMm.131870.

Genome annotation databases

EnsembliENSMUST00000021898; ENSMUSP00000021898; ENSMUSG00000021448.
GeneIDi20418.
KEGGimmu:20418.
UCSCiuc007qmg.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U46854 mRNA. Translation: AAC52508.1.
BC103612 mRNA. Translation: AAI03613.1.
BC105644 mRNA. Translation: AAI05645.1.
BC105645 mRNA. Translation: AAI05646.1.
CCDSiCCDS49265.1.
RefSeqiNP_033193.2. NM_009167.3.
UniGeneiMm.131870.

3D structure databases

ProteinModelPortaliQ61120.
SMRiQ61120. Positions 16-190, 372-473.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi203216. 3 interactions.
IntActiQ61120. 1 interaction.
MINTiMINT-258872.
STRINGi10090.ENSMUSP00000021898.

PTM databases

PhosphoSiteiQ61120.

Proteomic databases

MaxQBiQ61120.
PaxDbiQ61120.
PRIDEiQ61120.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000021898; ENSMUSP00000021898; ENSMUSG00000021448.
GeneIDi20418.
KEGGimmu:20418.
UCSCiuc007qmg.1. mouse.

Organism-specific databases

CTDi53358.
MGIiMGI:106179. Shc3.

Phylogenomic databases

eggNOGiNOG315087.
GeneTreeiENSGT00390000018860.
HOGENOMiHOG000231974.
HOVERGENiHBG050121.
InParanoidiQ61120.
KOiK17448.
OMAiGSDHPYY.
OrthoDBiEOG7MD4QK.
TreeFamiTF315807.

Enzyme and pathway databases

ReactomeiREACT_320246. Signalling to RAS.
REACT_333309. SHC-mediated signalling.
REACT_333431. Signal attenuation.

Miscellaneous databases

ChiTaRSiShc3. mouse.
NextBioi298416.
PROiQ61120.
SOURCEiSearch...

Gene expression databases

BgeeiQ61120.
GenevisibleiQ61120. MM.

Family and domain databases

Gene3Di2.30.29.30. 1 hit.
3.30.505.10. 1 hit.
InterProiIPR011993. PH-like_dom.
IPR006019. PID_Shc-like.
IPR006020. PTB/PI_dom.
IPR000980. SH2.
IPR029593. Shc3/ShcC/N-Shc.
[Graphical view]
PANTHERiPTHR10337:SF4. PTHR10337:SF4. 1 hit.
PfamiPF00640. PID. 1 hit.
PF00017. SH2. 1 hit.
[Graphical view]
PRINTSiPR00401. SH2DOMAIN.
PR00629. SHCPIDOMAIN.
SMARTiSM00462. PTB. 1 hit.
SM00252. SH2. 1 hit.
[Graphical view]
SUPFAMiSSF55550. SSF55550. 1 hit.
PROSITEiPS01179. PID. 1 hit.
PS50001. SH2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "A mammalian adaptor protein with conserved Src homology 2 and phosphotyrosine-binding domains is related to Shc and is specifically expressed in the brain."
    O'Bryan J.P., Songyang Z., Cantley L., Der C.J., Pawson T.
    Proc. Natl. Acad. Sci. U.S.A. 93:2729-2734(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].

Entry informationi

Entry nameiSHC3_MOUSE
AccessioniPrimary (citable) accession number: Q61120
Secondary accession number(s): Q3ZAX2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 29, 2004
Last sequence update: July 27, 2011
Last modified: July 22, 2015
This is version 110 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.