Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Q61120

- SHC3_MOUSE

UniProt

Q61120 - SHC3_MOUSE

Protein

SHC-transforming protein 3

Gene

Shc3

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 103 (01 Oct 2014)
      Sequence version 2 (27 Jul 2011)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Signaling adapter that couples activated growth factor receptors to signaling pathway in neurons. Involved in the signal transduction pathways of neurotrophin-activated Trk receptors in cortical neurons By similarity.By similarity

    GO - Molecular functioni

    1. protein binding Source: IntAct

    GO - Biological processi

    1. intracellular signal transduction Source: InterPro
    2. learning or memory Source: MGI
    3. synaptic transmission, glutamatergic Source: MGI

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    SHC-transforming protein 3
    Alternative name(s):
    Neuronal Shc
    Short name:
    N-Shc
    SHC-transforming protein C
    Src homology 2 domain-containing-transforming protein C3
    Short name:
    SH2 domain protein C3
    Gene namesi
    Name:Shc3
    Synonyms:Nshc, ShcC
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 13

    Organism-specific databases

    MGIiMGI:106179. Shc3.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 474474SHC-transforming protein 3PRO_0000097735Add
    BLAST

    Post-translational modificationi

    Tyrosine phosphorylated.By similarity

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    MaxQBiQ61120.
    PaxDbiQ61120.
    PRIDEiQ61120.

    PTM databases

    PhosphoSiteiQ61120.

    Expressioni

    Tissue specificityi

    Predominantly expressed in the adult brain.

    Gene expression databases

    BgeeiQ61120.
    GenevestigatoriQ61120.

    Interactioni

    Subunit structurei

    Interacts with the Trk receptors in a phosphotyrosine-dependent manner. Once activated, binds to GRB2. Interacts with activated EGF receptors By similarity.By similarity

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    AppP120232EBI-79107,EBI-78814

    Protein-protein interaction databases

    BioGridi203216. 3 interactions.
    IntActiQ61120. 1 interaction.
    MINTiMINT-258872.
    STRINGi10090.ENSMUSP00000021898.

    Structurei

    3D structure databases

    ProteinModelPortaliQ61120.
    SMRiQ61120. Positions 16-190, 372-473.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini29 – 214186PIDPROSITE-ProRule annotationAdd
    BLAST
    Domaini379 – 47092SH2PROSITE-ProRule annotationAdd
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni215 – 378164CH1Add
    BLAST

    Sequence similaritiesi

    Contains 1 PID domain.PROSITE-ProRule annotation
    Contains 1 SH2 domain.PROSITE-ProRule annotation

    Keywords - Domaini

    SH2 domain

    Phylogenomic databases

    eggNOGiNOG315087.
    GeneTreeiENSGT00390000018860.
    HOGENOMiHOG000231974.
    HOVERGENiHBG050121.
    InParanoidiQ3ZAX2.
    KOiK17448.
    OMAiGSDHPYY.
    OrthoDBiEOG7MD4QK.
    TreeFamiTF315807.

    Family and domain databases

    Gene3Di2.30.29.30. 1 hit.
    3.30.505.10. 1 hit.
    InterProiIPR011993. PH_like_dom.
    IPR006019. PID_Shc-like.
    IPR006020. PTB/PI_dom.
    IPR000980. SH2.
    [Graphical view]
    PfamiPF00640. PID. 1 hit.
    PF00017. SH2. 1 hit.
    [Graphical view]
    PRINTSiPR00401. SH2DOMAIN.
    PR00629. SHCPIDOMAIN.
    SMARTiSM00462. PTB. 1 hit.
    SM00252. SH2. 1 hit.
    [Graphical view]
    SUPFAMiSSF55550. SSF55550. 1 hit.
    PROSITEiPS01179. PID. 1 hit.
    PS50001. SH2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q61120-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSATRKSRAG DEPLPRPPRG APHTSDQVLG PGVTYVVKYL GCIEVLRSMR    50
    SLDFSTRTQV TREAISRVCE AVPGAKGALK KRKPPSKMLS SILGKSNLQF 100
    AGMSISLTIS TASLNLRTPD SKQIIANHHM RSISFASGGD PDTTDYVAYV 150
    AKDPVNRRAC HILECCDGLA QDVIGSIGQA FELRFKQYLQ CPSKVPALQD 200
    RMQSLDEPWT EEEGDGPDHP YYNSVPTKMP PPGGFLDARL KGRPHAPEAA 250
    QFAGKEQTYY QGRHLGDTFG EDWQRAPTRQ GSLDIYSTAE GKTHMVPVGE 300
    TPTYVNTQPV PPQVWPAATS STESSPRKDL FDMKPFEDAL RNQPLGPMLS 350
    KAASVECISP VTPRAPDARM LEELNAEPWY QGEMSRKEAE ALLREDGDFL 400
    VRKSTTNPGS FVLTGMHNGQ AKHLLLVDPE GTIRTKDRVF DSISHLINYH 450
    LESSLPIVSA GSELCLQQPV ERKP 474
    Length:474
    Mass (Da):52,121
    Last modified:July 27, 2011 - v2
    Checksum:i18550FB1C5F0F270
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti71 – 711A → R in AAC52508. (PubMed:8610109)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U46854 mRNA. Translation: AAC52508.1.
    BC103612 mRNA. Translation: AAI03613.1.
    BC105644 mRNA. Translation: AAI05645.1.
    BC105645 mRNA. Translation: AAI05646.1.
    CCDSiCCDS49265.1.
    RefSeqiNP_033193.2. NM_009167.3.
    UniGeneiMm.131870.

    Genome annotation databases

    EnsembliENSMUST00000021898; ENSMUSP00000021898; ENSMUSG00000021448.
    GeneIDi20418.
    KEGGimmu:20418.
    UCSCiuc007qmg.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U46854 mRNA. Translation: AAC52508.1 .
    BC103612 mRNA. Translation: AAI03613.1 .
    BC105644 mRNA. Translation: AAI05645.1 .
    BC105645 mRNA. Translation: AAI05646.1 .
    CCDSi CCDS49265.1.
    RefSeqi NP_033193.2. NM_009167.3.
    UniGenei Mm.131870.

    3D structure databases

    ProteinModelPortali Q61120.
    SMRi Q61120. Positions 16-190, 372-473.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 203216. 3 interactions.
    IntActi Q61120. 1 interaction.
    MINTi MINT-258872.
    STRINGi 10090.ENSMUSP00000021898.

    PTM databases

    PhosphoSitei Q61120.

    Proteomic databases

    MaxQBi Q61120.
    PaxDbi Q61120.
    PRIDEi Q61120.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000021898 ; ENSMUSP00000021898 ; ENSMUSG00000021448 .
    GeneIDi 20418.
    KEGGi mmu:20418.
    UCSCi uc007qmg.1. mouse.

    Organism-specific databases

    CTDi 53358.
    MGIi MGI:106179. Shc3.

    Phylogenomic databases

    eggNOGi NOG315087.
    GeneTreei ENSGT00390000018860.
    HOGENOMi HOG000231974.
    HOVERGENi HBG050121.
    InParanoidi Q3ZAX2.
    KOi K17448.
    OMAi GSDHPYY.
    OrthoDBi EOG7MD4QK.
    TreeFami TF315807.

    Miscellaneous databases

    ChiTaRSi SHC3. mouse.
    NextBioi 298416.
    PROi Q61120.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q61120.
    Genevestigatori Q61120.

    Family and domain databases

    Gene3Di 2.30.29.30. 1 hit.
    3.30.505.10. 1 hit.
    InterProi IPR011993. PH_like_dom.
    IPR006019. PID_Shc-like.
    IPR006020. PTB/PI_dom.
    IPR000980. SH2.
    [Graphical view ]
    Pfami PF00640. PID. 1 hit.
    PF00017. SH2. 1 hit.
    [Graphical view ]
    PRINTSi PR00401. SH2DOMAIN.
    PR00629. SHCPIDOMAIN.
    SMARTi SM00462. PTB. 1 hit.
    SM00252. SH2. 1 hit.
    [Graphical view ]
    SUPFAMi SSF55550. SSF55550. 1 hit.
    PROSITEi PS01179. PID. 1 hit.
    PS50001. SH2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "A mammalian adaptor protein with conserved Src homology 2 and phosphotyrosine-binding domains is related to Shc and is specifically expressed in the brain."
      O'Bryan J.P., Songyang Z., Cantley L., Der C.J., Pawson T.
      Proc. Natl. Acad. Sci. U.S.A. 93:2729-2734(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].

    Entry informationi

    Entry nameiSHC3_MOUSE
    AccessioniPrimary (citable) accession number: Q61120
    Secondary accession number(s): Q3ZAX2
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: March 29, 2004
    Last sequence update: July 27, 2011
    Last modified: October 1, 2014
    This is version 103 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3