Q61120 (SHC3_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
SHC-transforming protein 3

Alternative name(s):
Neuronal Shc
Short name=N-Shc
SHC-transforming protein C
Src homology 2 domain-containing-transforming protein C3
Short name=SH2 domain protein C3

Gene names

Name:	Shc3
Synonyms:	Nshc, ShcC

Organism

Mus musculus (Mouse) [Reference proteome]

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length	474 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Signaling adapter that couples activated growth factor receptors to signaling pathway in neurons. Involved in the signal transduction pathways of neurotrophin-activated Trk receptors in cortical neurons By similarity.
Subunit structure	Interacts with the Trk receptors in a phosphotyrosine-dependent manner. Once activated, binds to GRB2. Interacts with activated EGF receptors By similarity.
Tissue specificity	Predominantly expressed in the adult brain.
Post-translational modification	Tyrosine phosphorylated By similarity.
Sequence similarities	Contains 1 PID domain. Contains 1 SH2 domain.

Ontologies

Keywords
Domain	SH2 domain
PTM	Phosphoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	intracellular signal transduction Inferred from electronic annotation. Source: InterPro learning or memory Inferred from mutant phenotype PubMed 15716419. Source: MGI synaptic transmission, glutamatergic Inferred from mutant phenotype PubMed 15716419. Source: MGI
Complete GO annotation...

Binary interactions

With	Entry	#Exp.	IntAct	Notes
App	P12023	2	EBI-79107,EBI-78814

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 474	474	SHC-transforming protein 3		PRO_0000097735
Regions
	Domain	29 – 214	186	PID
	Domain	379 – 470	92	SH2
	Region	215 – 378	164	CH1
Experimental info
	Sequence conflict	71	1	A → R in AAC52508. Ref.1

Sequences

	Sequence		Length	Mass (Da)
	Q61120 [UniParc]. Last modified July 27, 2011. Version 2. Checksum: 18550FB1C5F0F270	FASTA	474	52,121
	10 20 30 40 50 60 MSATRKSRAG DEPLPRPPRG APHTSDQVLG PGVTYVVKYL GCIEVLRSMR SLDFSTRTQV 70 80 90 100 110 120 TREAISRVCE AVPGAKGALK KRKPPSKMLS SILGKSNLQF AGMSISLTIS TASLNLRTPD 130 140 150 160 170 180 SKQIIANHHM RSISFASGGD PDTTDYVAYV AKDPVNRRAC HILECCDGLA QDVIGSIGQA 190 200 210 220 230 240 FELRFKQYLQ CPSKVPALQD RMQSLDEPWT EEEGDGPDHP YYNSVPTKMP PPGGFLDARL 250 260 270 280 290 300 KGRPHAPEAA QFAGKEQTYY QGRHLGDTFG EDWQRAPTRQ GSLDIYSTAE GKTHMVPVGE 310 320 330 340 350 360 TPTYVNTQPV PPQVWPAATS STESSPRKDL FDMKPFEDAL RNQPLGPMLS KAASVECISP 370 380 390 400 410 420 VTPRAPDARM LEELNAEPWY QGEMSRKEAE ALLREDGDFL VRKSTTNPGS FVLTGMHNGQ 430 440 450 460 470 AKHLLLVDPE GTIRTKDRVF DSISHLINYH LESSLPIVSA GSELCLQQPV ERKP

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"A mammalian adaptor protein with conserved Src homology 2 and phosphotyrosine-binding domains is related to Shc and is specifically expressed in the brain." O'Bryan J.P., Songyang Z., Cantley L., Der C.J., Pawson T. Proc. Natl. Acad. Sci. U.S.A. 93:2729-2734(1996) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	U46854 mRNA. Translation: AAC52508.1. BC103612 mRNA. Translation: AAI03613.1. BC105644 mRNA. Translation: AAI05645.1. BC105645 mRNA. Translation: AAI05646.1.
IPI	IPI00117773.
RefSeq	NP_033193.2. NM_009167.3.
UniGene	Mm.131870.
3D structure databases
ProteinModelPortal	Q61120.
SMR	Q61120. Positions 16-190, 372-473.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q61120. 1 interaction.
MINT	MINT-258872.
STRING	10090.ENSMUSP00000021898.
PTM databases
PhosphoSite	Q61120.
Proteomic databases
PaxDb	Q61120.
PRIDE	Q61120.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSMUST00000021898; ENSMUSP00000021898; ENSMUSG00000021448.
GeneID	20418.
KEGG	mmu:20418.
Organism-specific databases
CTD	53358.
MGI	MGI:106179. Shc3.
Phylogenomic databases
eggNOG	NOG315087.
GeneTree	ENSGT00390000018860.
HOGENOM	HOG000231974.
HOVERGEN	HBG050121.
InParanoid	Q3ZAX2.
KO	K06279.
OMA	GSDHPYY.
OrthoDB	EOG4SF960.
Gene expression databases
Bgee	Q61120.
Genevestigator	Q61120.
GermOnline	ENSMUSG00000021448. Mus musculus.
Family and domain databases
Gene3D	2.30.29.30. 1 hit. 3.30.505.10. 1 hit.
InterPro	IPR011993. PH_like_dom. IPR006019. PID_domain. IPR006020. PTyr_interaction_dom. IPR000980. SH2. [Graphical view]
Pfam	PF00640. PID. 1 hit. PF00017. SH2. 1 hit. [Graphical view]
PRINTS	PR00401. SH2DOMAIN. PR00629. SHCPIDOMAIN.
SMART	SM00462. PTB. 1 hit. SM00252. SH2. 1 hit. [Graphical view]
PROSITE	PS01179. PID. 1 hit. PS50001. SH2. 1 hit. [Graphical view]
ProtoNet	Search...
Other
ChiTaRS	SHC3. mouse.
NextBio	298416.
SOURCE	Search...

Entry information

Entry name

SHC3_MOUSE

Accession

Primary (citable) accession number: Q61120
Secondary accession number(s): Q3ZAX2

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 29, 2004
Last sequence update:	July 27, 2011
Last modified:	April 3, 2013
This is version 91 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program