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Q61120

- SHC3_MOUSE

UniProt

Q61120 - SHC3_MOUSE

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Protein
SHC-transforming protein 3
Gene
Shc3, Nshc, ShcC
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at protein leveli

Functioni

Signaling adapter that couples activated growth factor receptors to signaling pathway in neurons. Involved in the signal transduction pathways of neurotrophin-activated Trk receptors in cortical neurons By similarity.

GO - Molecular functioni

  1. protein binding Source: IntAct
Complete GO annotation...

GO - Biological processi

  1. intracellular signal transduction Source: InterPro
  2. learning or memory Source: MGI
  3. synaptic transmission, glutamatergic Source: MGI
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
SHC-transforming protein 3
Alternative name(s):
Neuronal Shc
Short name:
N-Shc
SHC-transforming protein C
Src homology 2 domain-containing-transforming protein C3
Short name:
SH2 domain protein C3
Gene namesi
Name:Shc3
Synonyms:Nshc, ShcC
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 13

Organism-specific databases

MGIiMGI:106179. Shc3.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 474474SHC-transforming protein 3
PRO_0000097735Add
BLAST

Post-translational modificationi

Tyrosine phosphorylated By similarity.

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ61120.
PaxDbiQ61120.
PRIDEiQ61120.

PTM databases

PhosphoSiteiQ61120.

Expressioni

Tissue specificityi

Predominantly expressed in the adult brain.

Gene expression databases

BgeeiQ61120.
GenevestigatoriQ61120.

Interactioni

Subunit structurei

Interacts with the Trk receptors in a phosphotyrosine-dependent manner. Once activated, binds to GRB2. Interacts with activated EGF receptors By similarity.

Binary interactionsi

WithEntry#Exp.IntActNotes
AppP120232EBI-79107,EBI-78814

Protein-protein interaction databases

BioGridi203216. 3 interactions.
IntActiQ61120. 1 interaction.
MINTiMINT-258872.
STRINGi10090.ENSMUSP00000021898.

Structurei

3D structure databases

ProteinModelPortaliQ61120.
SMRiQ61120. Positions 16-190, 372-473.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini29 – 214186PID
Add
BLAST
Domaini379 – 47092SH2
Add
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni215 – 378164CH1
Add
BLAST

Sequence similaritiesi

Contains 1 PID domain.
Contains 1 SH2 domain.

Keywords - Domaini

SH2 domain

Phylogenomic databases

eggNOGiNOG315087.
GeneTreeiENSGT00390000018860.
HOGENOMiHOG000231974.
HOVERGENiHBG050121.
InParanoidiQ3ZAX2.
KOiK17448.
OMAiGSDHPYY.
OrthoDBiEOG7MD4QK.
TreeFamiTF315807.

Family and domain databases

Gene3Di2.30.29.30. 1 hit.
3.30.505.10. 1 hit.
InterProiIPR011993. PH_like_dom.
IPR006019. PID_Shc-like.
IPR006020. PTB/PI_dom.
IPR000980. SH2.
[Graphical view]
PfamiPF00640. PID. 1 hit.
PF00017. SH2. 1 hit.
[Graphical view]
PRINTSiPR00401. SH2DOMAIN.
PR00629. SHCPIDOMAIN.
SMARTiSM00462. PTB. 1 hit.
SM00252. SH2. 1 hit.
[Graphical view]
SUPFAMiSSF55550. SSF55550. 1 hit.
PROSITEiPS01179. PID. 1 hit.
PS50001. SH2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q61120-1 [UniParc]FASTAAdd to Basket

« Hide

MSATRKSRAG DEPLPRPPRG APHTSDQVLG PGVTYVVKYL GCIEVLRSMR    50
SLDFSTRTQV TREAISRVCE AVPGAKGALK KRKPPSKMLS SILGKSNLQF 100
AGMSISLTIS TASLNLRTPD SKQIIANHHM RSISFASGGD PDTTDYVAYV 150
AKDPVNRRAC HILECCDGLA QDVIGSIGQA FELRFKQYLQ CPSKVPALQD 200
RMQSLDEPWT EEEGDGPDHP YYNSVPTKMP PPGGFLDARL KGRPHAPEAA 250
QFAGKEQTYY QGRHLGDTFG EDWQRAPTRQ GSLDIYSTAE GKTHMVPVGE 300
TPTYVNTQPV PPQVWPAATS STESSPRKDL FDMKPFEDAL RNQPLGPMLS 350
KAASVECISP VTPRAPDARM LEELNAEPWY QGEMSRKEAE ALLREDGDFL 400
VRKSTTNPGS FVLTGMHNGQ AKHLLLVDPE GTIRTKDRVF DSISHLINYH 450
LESSLPIVSA GSELCLQQPV ERKP 474
Length:474
Mass (Da):52,121
Last modified:July 27, 2011 - v2
Checksum:i18550FB1C5F0F270
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti71 – 711A → R in AAC52508. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U46854 mRNA. Translation: AAC52508.1.
BC103612 mRNA. Translation: AAI03613.1.
BC105644 mRNA. Translation: AAI05645.1.
BC105645 mRNA. Translation: AAI05646.1.
CCDSiCCDS49265.1.
RefSeqiNP_033193.2. NM_009167.3.
UniGeneiMm.131870.

Genome annotation databases

EnsembliENSMUST00000021898; ENSMUSP00000021898; ENSMUSG00000021448.
GeneIDi20418.
KEGGimmu:20418.
UCSCiuc007qmg.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U46854 mRNA. Translation: AAC52508.1 .
BC103612 mRNA. Translation: AAI03613.1 .
BC105644 mRNA. Translation: AAI05645.1 .
BC105645 mRNA. Translation: AAI05646.1 .
CCDSi CCDS49265.1.
RefSeqi NP_033193.2. NM_009167.3.
UniGenei Mm.131870.

3D structure databases

ProteinModelPortali Q61120.
SMRi Q61120. Positions 16-190, 372-473.
ModBasei Search...

Protein-protein interaction databases

BioGridi 203216. 3 interactions.
IntActi Q61120. 1 interaction.
MINTi MINT-258872.
STRINGi 10090.ENSMUSP00000021898.

PTM databases

PhosphoSitei Q61120.

Proteomic databases

MaxQBi Q61120.
PaxDbi Q61120.
PRIDEi Q61120.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000021898 ; ENSMUSP00000021898 ; ENSMUSG00000021448 .
GeneIDi 20418.
KEGGi mmu:20418.
UCSCi uc007qmg.1. mouse.

Organism-specific databases

CTDi 53358.
MGIi MGI:106179. Shc3.

Phylogenomic databases

eggNOGi NOG315087.
GeneTreei ENSGT00390000018860.
HOGENOMi HOG000231974.
HOVERGENi HBG050121.
InParanoidi Q3ZAX2.
KOi K17448.
OMAi GSDHPYY.
OrthoDBi EOG7MD4QK.
TreeFami TF315807.

Miscellaneous databases

ChiTaRSi SHC3. mouse.
NextBioi 298416.
PROi Q61120.
SOURCEi Search...

Gene expression databases

Bgeei Q61120.
Genevestigatori Q61120.

Family and domain databases

Gene3Di 2.30.29.30. 1 hit.
3.30.505.10. 1 hit.
InterProi IPR011993. PH_like_dom.
IPR006019. PID_Shc-like.
IPR006020. PTB/PI_dom.
IPR000980. SH2.
[Graphical view ]
Pfami PF00640. PID. 1 hit.
PF00017. SH2. 1 hit.
[Graphical view ]
PRINTSi PR00401. SH2DOMAIN.
PR00629. SHCPIDOMAIN.
SMARTi SM00462. PTB. 1 hit.
SM00252. SH2. 1 hit.
[Graphical view ]
SUPFAMi SSF55550. SSF55550. 1 hit.
PROSITEi PS01179. PID. 1 hit.
PS50001. SH2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "A mammalian adaptor protein with conserved Src homology 2 and phosphotyrosine-binding domains is related to Shc and is specifically expressed in the brain."
    O'Bryan J.P., Songyang Z., Cantley L., Der C.J., Pawson T.
    Proc. Natl. Acad. Sci. U.S.A. 93:2729-2734(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].

Entry informationi

Entry nameiSHC3_MOUSE
AccessioniPrimary (citable) accession number: Q61120
Secondary accession number(s): Q3ZAX2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 29, 2004
Last sequence update: July 27, 2011
Last modified: July 9, 2014
This is version 102 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi