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Q61120 (SHC3_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 102. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Interactions·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
SHC-transforming protein 3
Alternative name(s):
Neuronal Shc
Short name=N-Shc
SHC-transforming protein C
Src homology 2 domain-containing-transforming protein C3
Short name=SH2 domain protein C3
Gene names
Name:Shc3
Synonyms:Nshc, ShcC
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length474 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Signaling adapter that couples activated growth factor receptors to signaling pathway in neurons. Involved in the signal transduction pathways of neurotrophin-activated Trk receptors in cortical neurons By similarity.

Subunit structure

Interacts with the Trk receptors in a phosphotyrosine-dependent manner. Once activated, binds to GRB2. Interacts with activated EGF receptors By similarity.

Tissue specificity

Predominantly expressed in the adult brain.

Post-translational modification

Tyrosine phosphorylated By similarity.

Sequence similarities

Contains 1 PID domain.

Contains 1 SH2 domain.

Binary interactions

With

Entry

#Exp.

IntAct

Notes

AppP120232EBI-79107,EBI-78814

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 474474SHC-transforming protein 3
PRO_0000097735

Regions

Domain29 – 214186PID
Domain379 – 47092SH2
Region215 – 378164CH1

Experimental info

Sequence conflict711A → R in AAC52508. Ref.1

Sequences

Sequence LengthMass (Da)Tools
Q61120 [UniParc].

Last modified July 27, 2011. Version 2.
Checksum: 18550FB1C5F0F270

FASTA47452,121
        10         20         30         40         50         60 
MSATRKSRAG DEPLPRPPRG APHTSDQVLG PGVTYVVKYL GCIEVLRSMR SLDFSTRTQV 

        70         80         90        100        110        120 
TREAISRVCE AVPGAKGALK KRKPPSKMLS SILGKSNLQF AGMSISLTIS TASLNLRTPD 

       130        140        150        160        170        180 
SKQIIANHHM RSISFASGGD PDTTDYVAYV AKDPVNRRAC HILECCDGLA QDVIGSIGQA 

       190        200        210        220        230        240 
FELRFKQYLQ CPSKVPALQD RMQSLDEPWT EEEGDGPDHP YYNSVPTKMP PPGGFLDARL 

       250        260        270        280        290        300 
KGRPHAPEAA QFAGKEQTYY QGRHLGDTFG EDWQRAPTRQ GSLDIYSTAE GKTHMVPVGE 

       310        320        330        340        350        360 
TPTYVNTQPV PPQVWPAATS STESSPRKDL FDMKPFEDAL RNQPLGPMLS KAASVECISP 

       370        380        390        400        410        420 
VTPRAPDARM LEELNAEPWY QGEMSRKEAE ALLREDGDFL VRKSTTNPGS FVLTGMHNGQ 

       430        440        450        460        470 
AKHLLLVDPE GTIRTKDRVF DSISHLINYH LESSLPIVSA GSELCLQQPV ERKP 

« Hide

References

« Hide 'large scale' references
[1]"A mammalian adaptor protein with conserved Src homology 2 and phosphotyrosine-binding domains is related to Shc and is specifically expressed in the brain."
O'Bryan J.P., Songyang Z., Cantley L., Der C.J., Pawson T.
Proc. Natl. Acad. Sci. U.S.A. 93:2729-2734(1996) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
U46854 mRNA. Translation: AAC52508.1.
BC103612 mRNA. Translation: AAI03613.1.
BC105644 mRNA. Translation: AAI05645.1.
BC105645 mRNA. Translation: AAI05646.1.
CCDSCCDS49265.1.
RefSeqNP_033193.2. NM_009167.3.
UniGeneMm.131870.

3D structure databases

ProteinModelPortalQ61120.
SMRQ61120. Positions 16-190, 372-473.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid203216. 3 interactions.
IntActQ61120. 1 interaction.
MINTMINT-258872.
STRING10090.ENSMUSP00000021898.

PTM databases

PhosphoSiteQ61120.

Proteomic databases

MaxQBQ61120.
PaxDbQ61120.
PRIDEQ61120.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000021898; ENSMUSP00000021898; ENSMUSG00000021448.
GeneID20418.
KEGGmmu:20418.
UCSCuc007qmg.1. mouse.

Organism-specific databases

CTD53358.
MGIMGI:106179. Shc3.

Phylogenomic databases

eggNOGNOG315087.
GeneTreeENSGT00390000018860.
HOGENOMHOG000231974.
HOVERGENHBG050121.
InParanoidQ3ZAX2.
KOK17448.
OMAGSDHPYY.
OrthoDBEOG7MD4QK.
TreeFamTF315807.

Gene expression databases

BgeeQ61120.
GenevestigatorQ61120.

Family and domain databases

Gene3D2.30.29.30. 1 hit.
3.30.505.10. 1 hit.
InterProIPR011993. PH_like_dom.
IPR006019. PID_Shc-like.
IPR006020. PTB/PI_dom.
IPR000980. SH2.
[Graphical view]
PfamPF00640. PID. 1 hit.
PF00017. SH2. 1 hit.
[Graphical view]
PRINTSPR00401. SH2DOMAIN.
PR00629. SHCPIDOMAIN.
SMARTSM00462. PTB. 1 hit.
SM00252. SH2. 1 hit.
[Graphical view]
SUPFAMSSF55550. SSF55550. 1 hit.
PROSITEPS01179. PID. 1 hit.
PS50001. SH2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSSHC3. mouse.
NextBio298416.
PROQ61120.
SOURCESearch...

Entry information

Entry nameSHC3_MOUSE
AccessionPrimary (citable) accession number: Q61120
Secondary accession number(s): Q3ZAX2
Entry history
Integrated into UniProtKB/Swiss-Prot: March 29, 2004
Last sequence update: July 27, 2011
Last modified: July 9, 2014
This is version 102 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot