Reviewed,
UniProtKB/Swiss-Prot Q61120 (SHC3_MOUSE)
Last modified
November 25, 2008.
Version 59.
History...
Clusters with 100%,
90%,
50% identity |
Documents (2) |
Third-party data |
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Names and origin
| Protein names | Recommended name: SHC-transforming protein 3 Alternative name(s): Src homology 2 domain-containing-transforming protein C3 Short name=SH2 domain protein C3 Neuronal Shc Short name=N-Shc | ||||
| Gene names |
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| Organism | Mus musculus (Mouse) | ||||
| Taxonomic identifier | 10090 [NCBI] | ||||
| Taxonomic lineage | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus |
Protein attributes
| Sequence length | 474 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is not processed. |
| Protein existence | Evidence at protein level. |
General annotation (Comments)
| Function | Signaling adapter that couples activated growth factor receptors to signaling pathway in neurons. Involved in the signal transduction pathways of neurotrophin-activated Trk receptors in cortical neurons By similarity. |
| Subunit structure | Interacts with the Trk receptors in a phosphotyrosine-dependent manner. Once activated, binds to GRB2. Interacts with activated EGF receptors By similarity. |
| Tissue specificity | Predominantly expressed in the adult brain. |
| Post-translational modification | Tyrosine phosphorylated By similarity. |
| Sequence similarities | Contains 1 PID domain. Contains 1 SH2 domain. |
Ontologies
Keywords | |
|---|---|
| Domain | SH2 domain |
| PTM | Phosphoprotein |
Gene Ontology (GO) | |
| Biological process | intracellular signaling cascade Inferred from electronic annotation. Source: InterPro learning or memoryInferred from mutant phenotype. Source: MGI synaptic transmission, glutamatergicInferred from mutant phenotype. Source: MGI |
| Molecular function | protein binding Inferred from physical interaction. Source: IntAct |
| Complete GO annotation... | |
Sequence annotation (Features)
Sequences
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References
| [1] | "A mammalian adaptor protein with conserved Src homology 2 and phosphotyrosine-binding domains is related to Shc and is specifically expressed in the brain." O'Bryan J.P., Songyang Z., Cantley L., Der C.J., Pawson T. Proc. Natl. Acad. Sci. U.S.A. 93:2729-2734(1996) [PubMed: 8610109] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. |
| + | Additional computationally mapped references. |
Cross-references
Sequence databases | |
|---|---|
| U46854 mRNA. Translation: AAC52508.1. | |
| RefSeq | NP_033193.2. |
| UniGene | Mm.247622 |
3D structure databases | |
| HSSP | HSSP built from PDB template 1SHC based on UniProtKB P29353. |
| SMR | Q61120. Positions 16-190. |
| ModBase | Search... |
Protein-protein interaction databases | |
| IntAct | Q61120. |
PTM databases | |
| PhosphoSite | Q61120. |
Genome annotation databases | |
| Ensembl | ENSMUSG00000021448. Mus musculus. [Contig view] |
| GeneID | 20418. |
| KEGG | mmu:20418. |
Organism-specific databases | |
| MGI | MGI:106179. Shc3. |
Phylogenomic databases | |
| HOGENOM | Q61120. |
| HOVERGEN | Q61120. |
Gene expression databases | |
| ArrayExpress | Q61120. |
| GermOnline | ENSMUSG00000021448. Mus musculus. |
Family and domain databases | |
| InterPro | IPR011993. PH_type. IPR006019. PID_domain. IPR006020. PTB_PID. IPR000980. SH2. [Graphical view] |
| Gene3D | G3DSA:2.30.29.30. PH_type. 1 hit. G3DSA:3.30.505.10. SH2. 1 hit. |
| Pfam | PF00640. PID. 1 hit. PF00017. SH2. 1 hit. [Graphical view] |
| PRINTS | PR00401. SH2DOMAIN. PR00629. SHCPIDOMAIN. |
| ProDom | PD000093. SH2. 1 hit. [Graphical view] [Entries sharing at least one domain] |
| SMART | SM00462. PTB. 1 hit. SM00252. SH2. 1 hit. [Graphical view] |
| PROSITE | PS01179. PID. 1 hit. PS50001. SH2. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Other Resources | |
| NextBio | 298416. |
| SOURCE | Search... |
Entry information
| Entry name | SHC3_MOUSE | ||||||||
| Accession | Primary (citable) accession number: Q61120 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | HPI (Human Proteome Initiative) | ||||||||
Relevant documents
| MGD cross-references Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot |
| SIMILARITY comments Index of protein domains and families |

Clusters with


