Reviewed, UniProtKB/Swiss-Prot Q61120 (SHC3_MOUSE)

Names and origin

Protein names

Recommended name:
    SHC-transforming protein 3
Alternative name(s):
    Src homology 2 domain-containing-transforming protein C3
      Short name=SH2 domain protein C3
    Neuronal Shc
      Short name=N-Shc

Gene names

Name:	Shc3
Synonyms:	Nshc, ShcC

Organism

Mus musculus (Mouse)

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus

Protein attributes

Sequence length	474 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at protein level.

General annotation (Comments)

Function	Signaling adapter that couples activated growth factor receptors to signaling pathway in neurons. Involved in the signal transduction pathways of neurotrophin-activated Trk receptors in cortical neurons By similarity.
Subunit structure	Interacts with the Trk receptors in a phosphotyrosine-dependent manner. Once activated, binds to GRB2. Interacts with activated EGF receptors By similarity.
Tissue specificity	Predominantly expressed in the adult brain.
Post-translational modification	Tyrosine phosphorylated By similarity.
Sequence similarities	Contains 1 PID domain. Contains 1 SH2 domain.

Ontologies

Keywords
Domain	SH2 domain
PTM	Phosphoprotein
Gene Ontology (GO)
Biological process	intracellular signaling cascade Inferred from electronic annotation. Source: InterPro learning or memory Inferred from mutant phenotype. Source: MGI synaptic transmission, glutamatergic Inferred from mutant phenotype. Source: MGI
Molecular function	protein binding Inferred from physical interaction. Source: IntAct
Complete GO annotation...

Binary interactions

With	Entry	#Exp.	IntAct	Notes
App	P12023	1	EBI-79107,EBI-78814

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 474	474	SHC-transforming protein 3		PRO_0000097735
Regions
	Domain	29 – 214	186	PID
	Domain	379 – 470	92	SH2
	Region	215 – 378	164	CH1

Sequences

	Sequence		Length	Mass (Da)
	Q61120-1 [UniParc]. Last modified November 1, 1996. Version 1. Checksum: DEE6CBA83A54A6C4	FASTA	474	52,206
	10 20 30 40 50 60 MSATRKSRAG DEPLPRPPRG APHTSDQVLG PGVTYVVKYL GCIEVLRSMR SLDFSTRTQV 70 80 90 100 110 120 TREAISRVCE RVPGAKGALK KRKPPSKMLS SILGKSNLQF AGMSISLTIS TASLNLRTPD 130 140 150 160 170 180 SKQIIANHHM RSISFASGGD PDTTDYVAYV AKDPVNRRAC HILECCDGLA QDVIGSIGQA 190 200 210 220 230 240 FELRFKQYLQ CPSKVPALQD RMQSLDEPWT EEEGDGPDHP YYNSVPTKMP PPGGFLDARL 250 260 270 280 290 300 KGRPHAPEAA QFAGKEQTYY QGRHLGDTFG EDWQRAPTRQ GSLDIYSTAE GKTHMVPVGE 310 320 330 340 350 360 TPTYVNTQPV PPQVWPAATS STESSPRKDL FDMKPFEDAL RNQPLGPMLS KAASVECISP 370 380 390 400 410 420 VTPRAPDARM LEELNAEPWY QGEMSRKEAE ALLREDGDFL VRKSTTNPGS FVLTGMHNGQ 430 440 450 460 470 AKHLLLVDPE GTIRTKDRVF DSISHLINYH LESSLPIVSA GSELCLQQPV ERKP

References

[1]	"A mammalian adaptor protein with conserved Src homology 2 and phosphotyrosine-binding domains is related to Shc and is specifically expressed in the brain." O'Bryan J.P., Songyang Z., Cantley L., Der C.J., Pawson T. Proc. Natl. Acad. Sci. U.S.A. 93:2729-2734(1996) [PubMed: 8610109] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBLGenBankDDBJ	U46854 mRNA. Translation: AAC52508.1.
RefSeq	NP_033193.2.
UniGene	Mm.247622
3D structure databases
HSSP	HSSP built from PDB template 1SHC based on UniProtKB P29353.
SMR	Q61120. Positions 16-190.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q61120.
PTM databases
PhosphoSite	Q61120.
Genome annotation databases
Ensembl	ENSMUSG00000021448. Mus musculus. [Contig view]
GeneID	20418.
KEGG	mmu:20418.
Organism-specific databases
MGI	MGI:106179. Shc3.
Phylogenomic databases
HOGENOM	Q61120.
HOVERGEN	Q61120.
Gene expression databases
ArrayExpress	Q61120.
GermOnline	ENSMUSG00000021448. Mus musculus.
Family and domain databases
InterPro	IPR011993. PH_type. IPR006019. PID_domain. IPR006020. PTB_PID. IPR000980. SH2. [Graphical view]
Gene3D	G3DSA:2.30.29.30. PH_type. 1 hit. G3DSA:3.30.505.10. SH2. 1 hit.
Pfam	PF00640. PID. 1 hit. PF00017. SH2. 1 hit. [Graphical view]
PRINTS	PR00401. SH2DOMAIN. PR00629. SHCPIDOMAIN.
ProDom	PD000093. SH2. 1 hit. [Graphical view] [Entries sharing at least one domain]
SMART	SM00462. PTB. 1 hit. SM00252. SH2. 1 hit. [Graphical view]
PROSITE	PS01179. PID. 1 hit. PS50001. SH2. 1 hit. [Graphical view]
ProtoNet	Search...
Other Resources
NextBio	298416.
SOURCE	Search...

Entry information

Entry name

SHC3_MOUSE

Accession

Primary (citable) accession number: Q61120

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 29, 2004
Last sequence update:	November 1, 1996
Last modified:	November 25, 2008
This is version 59 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)