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Protein

Zinc finger protein 235

Gene

Znf235

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

May be involved in transcriptional regulation.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri285 – 307C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri313 – 335C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri341 – 363C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri369 – 391C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri397 – 419C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri425 – 447C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri453 – 475C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri481 – 503C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri509 – 531C2H2-type 9PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri537 – 559C2H2-type 10PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri565 – 587C2H2-type 11PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri593 – 615C2H2-type 12PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri621 – 643C2H2-type 13PROSITE-ProRule annotationAdd BLAST23

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 235
Alternative name(s):
Zinc finger protein 93
Short name:
Zfp-93
Gene namesi
Name:Znf235
Synonyms:Zfp93
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 7

Organism-specific databases

MGIiMGI:107611. Zfp93.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000474751 – 645Zinc finger protein 235Add BLAST645

Proteomic databases

PaxDbiQ61116.
PRIDEiQ61116.

PTM databases

iPTMnetiQ61116.
PhosphoSitePlusiQ61116.

Expressioni

Gene expression databases

BgeeiENSMUSG00000055305.
CleanExiMM_ZFP93.
GenevisibleiQ61116. MM.

Interactioni

Protein-protein interaction databases

BioGridi204682. 1 interactor.
STRINGi10090.ENSMUSP00000032696.

Structurei

3D structure databases

ProteinModelPortaliQ61116.
SMRiQ61116.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini8 – 86KRABPROSITE-ProRule annotationAdd BLAST79

Sequence similaritiesi

Contains 13 C2H2-type zinc fingers.PROSITE-ProRule annotation
Contains 1 KRAB domain.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri285 – 307C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri313 – 335C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri341 – 363C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri369 – 391C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri397 – 419C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri425 – 447C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri453 – 475C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri481 – 503C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri509 – 531C2H2-type 9PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri537 – 559C2H2-type 10PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri565 – 587C2H2-type 11PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri593 – 615C2H2-type 12PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri621 – 643C2H2-type 13PROSITE-ProRule annotationAdd BLAST23

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00840000129740.
HOGENOMiHOG000234617.
HOVERGENiHBG018163.
InParanoidiQ61116.
KOiK09228.
OMAiWSSHLYV.
OrthoDBiEOG091G02KC.
PhylomeDBiQ61116.
TreeFamiTF350845.

Family and domain databases

CDDicd07765. KRAB_A-box. 1 hit.
Gene3Di3.30.160.60. 13 hits.
InterProiIPR001909. KRAB.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF01352. KRAB. 1 hit.
PF00096. zf-C2H2. 5 hits.
[Graphical view]
SMARTiSM00349. KRAB. 1 hit.
SM00355. ZnF_C2H2. 13 hits.
[Graphical view]
SUPFAMiSSF109640. SSF109640. 1 hit.
PROSITEiPS50805. KRAB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 13 hits.
PS50157. ZINC_FINGER_C2H2_2. 13 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q61116-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTKLQEMVTF RDVAVVFSEE ELGLLDAAQR KLYHDVMLEN FRNLLAVGCQ
60 70 80 90 100
SPNKMAPLDT TGIRCLPLGQ LPCWQMTSHD VNKLARAPED GINTPGKGPH
110 120 130 140 150
LLEQCHSSCH WGAEQPSQAP EDDGCLENLP SNHSSSSDNQ EFLSGRAQSS
160 170 180 190 200
WSKAHFSERW NHEKHCPQTL VKTKSQLLAP GVNILGCISH HDHNILHKRD
210 220 230 240 250
KVPSSGDCDQ VIFPMTLLTQ HCVYREQKAY QCSRGQEVFS DSPSLELHQQ
260 270 280 290 300
TLLGKKSPVH STHKDTRHSP SVPIQPSVHP GRKRYWCHEC GKGFRQSSAL
310 320 330 340 350
QTHQRVHTGE KPYRCDSCGK GFSRSSDLNI HRRVHTGEKP YKCEVCGKGF
360 370 380 390 400
TQWAHLQAHE RIHTGEKPYK CGDCGKRFSC SSNLHTHQRV HTEEKPYECN
410 420 430 440 450
ECGKRFSLSG NLDIHQRVHT GEKPYKCEEC GKGFSSASSF QSHQRVHTGE
460 470 480 490 500
KPFHCSVCGK NFSRSSHFLD HQRIHTGEKP YRCEVCGKRF PWSLSLHSHQ
510 520 530 540 550
SVHTGKKPYK CGECGKGFSH ASSLQAHHSV HTGEKPFKCN VCQKQFSKTS
560 570 580 590 600
NLQAHQRVHT GEKPYKCDTC GKAFSQKSSL QVHQRIHTGE KPFKCEECGK
610 620 630 640
EFRWSVGLSS HQRVHTGEKP YTCQQCGKGF SQASYFHMHQ RVHTI
Length:645
Mass (Da):73,012
Last modified:November 1, 1996 - v1
Checksum:i7459CD140F5AF469
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti85A → P in BAC26187 (PubMed:16141072).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U46186 mRNA. Translation: AAB03529.1.
AK028905 mRNA. Translation: BAC26187.1.
AK040325 mRNA. Translation: BAC30565.1.
AK132229 mRNA. Translation: BAE21045.1.
AK146095 mRNA. Translation: BAE26898.1.
BC003776 mRNA. Translation: AAH03776.1.
CCDSiCCDS39828.1.
RefSeqiNP_033593.1. NM_009567.4.
XP_017177632.1. XM_017322143.1.
UniGeneiMm.383535.
Mm.459431.

Genome annotation databases

EnsembliENSMUST00000032696; ENSMUSP00000032696; ENSMUSG00000055305.
ENSMUST00000108438; ENSMUSP00000104077; ENSMUSG00000055305.
GeneIDi22755.
KEGGimmu:22755.
UCSCiuc009fpe.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U46186 mRNA. Translation: AAB03529.1.
AK028905 mRNA. Translation: BAC26187.1.
AK040325 mRNA. Translation: BAC30565.1.
AK132229 mRNA. Translation: BAE21045.1.
AK146095 mRNA. Translation: BAE26898.1.
BC003776 mRNA. Translation: AAH03776.1.
CCDSiCCDS39828.1.
RefSeqiNP_033593.1. NM_009567.4.
XP_017177632.1. XM_017322143.1.
UniGeneiMm.383535.
Mm.459431.

3D structure databases

ProteinModelPortaliQ61116.
SMRiQ61116.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi204682. 1 interactor.
STRINGi10090.ENSMUSP00000032696.

PTM databases

iPTMnetiQ61116.
PhosphoSitePlusiQ61116.

Proteomic databases

PaxDbiQ61116.
PRIDEiQ61116.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000032696; ENSMUSP00000032696; ENSMUSG00000055305.
ENSMUST00000108438; ENSMUSP00000104077; ENSMUSG00000055305.
GeneIDi22755.
KEGGimmu:22755.
UCSCiuc009fpe.1. mouse.

Organism-specific databases

CTDi22755.
MGIiMGI:107611. Zfp93.

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00840000129740.
HOGENOMiHOG000234617.
HOVERGENiHBG018163.
InParanoidiQ61116.
KOiK09228.
OMAiWSSHLYV.
OrthoDBiEOG091G02KC.
PhylomeDBiQ61116.
TreeFamiTF350845.

Miscellaneous databases

PROiQ61116.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000055305.
CleanExiMM_ZFP93.
GenevisibleiQ61116. MM.

Family and domain databases

CDDicd07765. KRAB_A-box. 1 hit.
Gene3Di3.30.160.60. 13 hits.
InterProiIPR001909. KRAB.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF01352. KRAB. 1 hit.
PF00096. zf-C2H2. 5 hits.
[Graphical view]
SMARTiSM00349. KRAB. 1 hit.
SM00355. ZnF_C2H2. 13 hits.
[Graphical view]
SUPFAMiSSF109640. SSF109640. 1 hit.
PROSITEiPS50805. KRAB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 13 hits.
PS50157. ZINC_FINGER_C2H2_2. 13 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiZN235_MOUSE
AccessioniPrimary (citable) accession number: Q61116
Secondary accession number(s): Q3UKA3, Q8CE70
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: November 1, 1996
Last modified: November 2, 2016
This is version 134 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.