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Reviewed, UniProtKB/Swiss-Prot Q61115 (PTC1_MOUSE)

Last modified February 9, 2010. Version 81. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

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Names and origin

Protein namesRecommended name:
    Protein patched homolog 1
      Short name=PTC1
      Short name=PTC
Gene names
Name: Ptch1
Synonyms: Ptch
OrganismMus musculus (Mouse)
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus

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Protein attributes

Sequence length1434 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level.

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General annotation (Comments)

Function

Acts as a receptor for sonic hedgehog (SHH), indian hedgehog (IHH) and desert hedgehog (DHH). Associates with the smoothened protein (SMO) to transduce the hedgehog's proteins signal. Seems to have a tumor suppressor function, as inactivation of this protein is probably a necessary, if not sufficient step for tumorigenesis.

Subunit structure

Interacts with SNX17 By similarity.

Subcellular location

Membrane; Multi-pass membrane protein.

Developmental stage

Expressed at low level at 7 dpc, higher level at 11 and 15 dpc, and persists at moderate levels at 17 dpc. In the developing embryo, PTC is first detected within the ventral neural tube and later in the somites and limb buds. Expression in the limb buds is restricted to the posterior ectoderm surrounding the zone of polarizing activity. In the adult, expression is seen in brain, lung, liver, kidney and ocular tissues; lower levels in heart, skeletal muscle, and testis.

Induction

Activated by Sonic hedgehog.

Post-translational modification

Glycosylation is necessary for SHH binding By similarity.

Sequence similarities

Belongs to the patched family.

Contains 1 SSD (sterol-sensing) domain.

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Ontologies

Keywords
   Cellular componentMembrane
   DomainTransmembrane
   Molecular functionReceptor
   PTMGlycoprotein
Gene Ontology (GO)
   Biological processdorsal/ventral neural tube patterning

Inferred from mutant phenotype. Source: MGI

embryonic limb morphogenesis

Inferred from mutant phenotype. Source: MGI

epidermis development

Inferred from mutant phenotype. Source: MGI

glucose homeostasis

Inferred from mutant phenotype. Source: MGI

heart morphogenesis

Inferred from mutant phenotype. Source: MGI

hindlimb morphogenesis

Inferred from mutant phenotype. Source: MGI

keratinocyte proliferation

Inferred from mutant phenotype. Source: MGI

mammary gland duct morphogenesis

Inferred from mutant phenotype. Source: MGI

mammary gland epithelial cell differentiation

Inferred from mutant phenotype. Source: MGI

negative regulation of epithelial cell proliferation

Inferred from mutant phenotype. Source: MGI

negative regulation of multicellular organism growth

Inferred from mutant phenotype. Source: MGI

neural tube closure

Inferred from mutant phenotype. Source: MGI

protein processing

Inferred from mutant phenotype. Source: MGI

regulation of smoothened signaling pathway

Inferred from mutant phenotype. Source: MGI

response to chlorate

Inferred from direct assay. Source: MGI

smoothened signaling pathway

Inferred from direct assay. Source: MGI

   Cellular componentextracellular region

Traceable author statement. Source: Roslin

integral to plasma membrane

Traceable author statement. Source: MGI

   Molecular functioncholesterol binding

Traceable author statement. Source: Roslin

hedgehog receptor activity

Traceable author statement. Source: MGI

heparin binding

Inferred from direct assay. Source: Roslin

patched binding

Inferred from direct assay. Source: Roslin

zinc ion binding

Non-traceable author statement. Source: Roslin

Complete GO annotation...

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Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 14341434Protein patched homolog 1
PRO_0000205965

Regions

Topological domain1 – 8686Cytoplasmic Potential
Transmembrane87 – 10721 Potential
Topological domain108 – 422315Extracellular Potential
Transmembrane423 – 44321 Potential
Topological domain444 – 45815Cytoplasmic Potential
Transmembrane459 – 47921 Potential
Topological domain480 – 4878Extracellular Potential
Transmembrane488 – 50821 Potential
Topological domain509 – 53325Cytoplasmic Potential
Transmembrane534 – 55421 Potential
Topological domain555 – 5639Extracellular Potential
Transmembrane564 – 58421 Potential
Topological domain585 – 734150Cytoplasmic Potential
Transmembrane735 – 75521 Potential
Topological domain756 – 1013258Extracellular Potential
Transmembrane1014 – 103421 Potential
Topological domain1035 – 10395Cytoplasmic Potential
Transmembrane1040 – 106021 Potential
Topological domain1061 – 10699Extracellular Potential
Transmembrane1070 – 109021 Potential
Topological domain1091 – 110717Cytoplasmic Potential
Transmembrane1108 – 112821 Potential
Topological domain1129 – 114012Extracellular Potential
Transmembrane1141 – 116121 Potential
Topological domain1162 – 1434273Cytoplasmic Potential
Domain424 – 584161SSD

Amino acid modifications

Glycosylation1271N-linked (GlcNAc...) Potential
Glycosylation2981N-linked (GlcNAc...) Potential
Glycosylation3351N-linked (GlcNAc...) Potential
Glycosylation4001N-linked (GlcNAc...) Potential
Glycosylation8611N-linked (GlcNAc...) Potential
Glycosylation9861N-linked (GlcNAc...) Potential

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Sequences

Sequence LengthMass (Da)Tools
Q61115-1 [UniParc].

Last modified November 1, 1996. Version 1.
Checksum: A5E9189E633173D0

FASTA1,434159,273
        10         20         30         40         50         60 
MASAGNAAGA LGRQAGGGRR RRTGGPHRAA PDRDYLHRPS YCDAAFALEQ ISKGKATGRK 

        70         80         90        100        110        120 
APLWLRAKFQ RLLFKLGCYI QKNCGKFLVV GLLIFGAFAV GLKAANLETN VEELWVEVGG 

       130        140        150        160        170        180 
RVSRELNYTR QKIGEEAMFN PQLMIQTPKE EGANVLTTEA LLQHLDSALQ ASRVHVYMYN 

       190        200        210        220        230        240 
RQWKLEHLCY KSGELITETG YMDQIIEYLY PCLIITPLDC FWEGAKLQSG TAYLLGKPPL 

       250        260        270        280        290        300 
RWTNFDPLEF LEELKKINYQ VDSWEEMLNK AEVGHGYMDR PCLNPADPDC PATAPNKNST 

       310        320        330        340        350        360 
KPLDVALVLN GGCQGLSRKY MHWQEELIVG GTVKNATGKL VSAHALQTMF QLMTPKQMYE 

       370        380        390        400        410        420 
HFRGYDYVSH INWNEDRAAA ILEAWQRTYV EVVHQSVAPN STQKVLPFTT TTLDDILKSF 

       430        440        450        460        470        480 
SDVSVIRVAS GYLLMLAYAC LTMLRWDCSK SQGAVGLAGV LLVALSVAAG LGLCSLIGIS 

       490        500        510        520        530        540 
FNAATTQVLP FLALGVGVDD VFLLAHAFSE TGQNKRIPFE DRTGECLKRT GASVALTSIS 

       550        560        570        580        590        600 
NVTAFFMAAL IPIPALRAFS LQAAVVVVFN FAMVLLIFPA ILSMDLYRRE DRRLDIFCCF 

       610        620        630        640        650        660 
TSPCVSRVIQ VEPQAYTEPH SNTRYSPPPP YTSHSFAHET HITMQSTVQL RTEYDPHTHV 

       670        680        690        700        710        720 
YYTTAEPRSE ISVQPVTVTQ DNLSCQSPES TSSTRDLLSQ FSDSSLHCLE PPCTKWTLSS 

       730        740        750        760        770        780 
FAEKHYAPFL LKPKAKVVVI LLFLGLLGVS LYGTTRVRDG LDLTDIVPRE TREYDFIAAQ 

       790        800        810        820        830        840 
FKYFSFYNMY IVTQKADYPN IQHLLYDLHK SFSNVKYVML EENKQLPQMW LHYFRDWLQG 

       850        860        870        880        890        900 
LQDAFDSDWE TGRIMPNNYK NGSDDGVLAY KLLVQTGSRD KPIDISQLTK QRLVDADGII 

       910        920        930        940        950        960 
NPSAFYIYLT AWVSNDPVAY AASQANIRPH RPEWVHDKAD YMPETRLRIP AAEPIEYAQF 

       970        980        990       1000       1010       1020 
PFYLNGLRDT SDFVEAIEKV RVICNNYTSL GLSSYPNGYP FLFWEQYISL RHWLLLSISV 

      1030       1040       1050       1060       1070       1080 
VLACTFLVCA VFLLNPWTAG IIVMVLALMT VELFGMMGLI GIKLSAVPVV ILIASVGIGV 

      1090       1100       1110       1120       1130       1140 
EFTVHVALAF LTAIGDKNHR AMLALEHMFA PVLDGAVSTL LGVLMLAGSE FDFIVRYFFA 

      1150       1160       1170       1180       1190       1200 
VLAILTVLGV LNGLVLLPVL LSFFGPCPEV SPANGLNRLP TPSPEPPPSV VRFAVPPGHT 

      1210       1220       1230       1240       1250       1260 
NNGSDSSDSE YSSQTTVSGI SEELRQYEAQ QGAGGPAHQV IVEATENPVF ARSTVVHPDS 

      1270       1280       1290       1300       1310       1320 
RHQPPLTPRQ QPHLDSGSLS PGRQGQQPRR DPPREGLRPP PYRPRRDAFE ISTEGHSGPS 

      1330       1340       1350       1360       1370       1380 
NRDRSGPRGA RSHNPRNPTS TAMGSSVPSY CQPITTVTAS ASVTVAVHPP PGPGRNPRGG 

      1390       1400       1410       1420       1430 
PCPGYESYPE TDHGVFEDPH VPFHVRCERR DSKVEVIELQ DVECEERPWG SSSN

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References

[1]"Conservation of the hedgehog/patched signaling pathway from flies to mice: induction of a mouse patched gene by Hedgehog."
Goodrich L.V., Johnson R.L., Milenkovic L., McMahon J.A., Scott M.P.
Genes Dev. 10:301-312(1996) [PubMed: 8595881] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Embryo.
+Additional computationally mapped references.

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Cross-references

Sequence databases

EMBL
GenBank
DDBJ		U46155 mRNA. Translation: AAC98798.1.
IPIIPI00117758.
PIRT30172.
RefSeqNP_032983.1.
UniGeneMm.228798

3D structure databases

SMRQ61115. Positions 89-118.
ModBaseSearch...

Protein-protein interaction databases

STRINGQ61115.

PTM databases

PhosphoSiteQ61115.

Proteomic databases

PRIDEQ61115.

Genome annotation databases

EnsemblENSMUST00000021921; ENSMUSP00000021921; ENSMUSG00000021466; Mus musculus. [Genome view]
GeneID19206.
KEGGmmu:19206.
UCSCuc007qxv.1. mouse.

Organism-specific databases

CTD19206.
MGIMGI:105373. Ptch1.

Phylogenomic databases

HOGENOMHBG713504.
HOVERGENQ61115.
InParanoidQ61115.
OMARPSYCDA.
OrthoDBEOG9B5RQR.
PhylomeDBQ61115.

Gene expression databases

ArrayExpressQ61115.
BgeeQ61115.
CleanExMM_PTCH1.
GenevestigatorQ61115.
GermOnlineENSMUSG00000021466. Mus musculus.

Family and domain databases

InterProIPR003392. Patched.
IPR000731. SSD_5TM.
IPR004766. TM_rcpt_patched.
[Graphical view]
PfamPF02460. Patched. 1 hit.
[Graphical view]
TIGRFAMsTIGR00918. 2A060602. 1 hit.
PROSITEPS50156. SSD. 1 hit.
[Graphical view]
ProtoNetSearch...

Other Resources

NextBio295938.
SOURCESearch...

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Entry information

Entry namePTC1_MOUSE
AccessionPrimary (citable) accession number: Q61115
Entry history
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: November 1, 1996
Last modified: February 9, 2010
This is version 81 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHPI (Human Proteome Initiative)

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Relevant documents

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents