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Q61115

- PTC1_MOUSE

UniProt

Q61115 - PTC1_MOUSE

Protein

Protein patched homolog 1

Gene

Ptch1

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 119 (01 Oct 2014)
      Sequence version 1 (01 Nov 1996)
      Previous versions | rss
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    Functioni

    Acts as a receptor for sonic hedgehog (SHH), indian hedgehog (IHH) and desert hedgehog (DHH). Associates with the smoothened protein (SMO) to transduce the hedgehog's proteins signal. Seems to have a tumor suppressor function, as inactivation of this protein is probably a necessary, if not sufficient step for tumorigenesis.1 Publication

    GO - Molecular functioni

    1. cholesterol binding Source: Roslin
    2. cyclin binding Source: BHF-UCL
    3. hedgehog receptor activity Source: MGI
    4. heparin binding Source: Roslin
    5. patched binding Source: Roslin
    6. protein binding Source: UniProtKB
    7. protein complex binding Source: BHF-UCL
    8. zinc ion binding Source: Roslin

    GO - Biological processi

    1. brain development Source: BHF-UCL
    2. branching involved in ureteric bud morphogenesis Source: MGI
    3. cell differentiation involved in kidney development Source: MGI
    4. cell proliferation involved in metanephros development Source: MGI
    5. cellular response to cholesterol Source: BHF-UCL
    6. dorsal/ventral neural tube patterning Source: MGI
    7. dorsal/ventral pattern formation Source: MGI
    8. embryonic limb morphogenesis Source: MGI
    9. embryonic organ development Source: MGI
    10. epidermis development Source: MGI
    11. glucose homeostasis Source: MGI
    12. heart morphogenesis Source: MGI
    13. hindlimb morphogenesis Source: MGI
    14. in utero embryonic development Source: MGI
    15. keratinocyte proliferation Source: MGI
    16. mammary gland development Source: MGI
    17. mammary gland duct morphogenesis Source: MGI
    18. mammary gland epithelial cell differentiation Source: MGI
    19. negative regulation of cell division Source: BHF-UCL
    20. negative regulation of cell proliferation Source: BHF-UCL
    21. negative regulation of epithelial cell proliferation Source: MGI
    22. negative regulation of multicellular organism growth Source: MGI
    23. negative regulation of osteoblast differentiation Source: Ensembl
    24. negative regulation of sequence-specific DNA binding transcription factor activity Source: Ensembl
    25. negative regulation of smoothened signaling pathway Source: BHF-UCL
    26. negative regulation of transcription from RNA polymerase II promoter Source: Ensembl
    27. neural plate axis specification Source: BHF-UCL
    28. neural tube closure Source: MGI
    29. neural tube formation Source: Roslin
    30. organ morphogenesis Source: MGI
    31. pattern specification process Source: MGI
    32. pharyngeal system development Source: Ensembl
    33. positive regulation of cholesterol efflux Source: Ensembl
    34. protein processing Source: MGI
    35. protein targeting to plasma membrane Source: Ensembl
    36. regulation of cell proliferation Source: MGI
    37. regulation of growth Source: MGI
    38. regulation of mitotic cell cycle Source: MGI
    39. regulation of protein localization Source: BHF-UCL
    40. regulation of smoothened signaling pathway Source: MGI
    41. response to chlorate Source: MGI
    42. response to drug Source: Ensembl
    43. response to estradiol Source: Ensembl
    44. response to mechanical stimulus Source: Ensembl
    45. response to retinoic acid Source: Ensembl
    46. signal transduction Source: Roslin
    47. smoothened signaling pathway Source: MGI
    48. smoothened signaling pathway involved in dorsal/ventral neural tube patterning Source: MGI
    49. somite development Source: BHF-UCL
    50. spinal cord motor neuron differentiation Source: MGI

    Keywords - Molecular functioni

    Receptor

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Protein patched homolog 1
    Short name:
    PTC
    Short name:
    PTC1
    Gene namesi
    Name:Ptch1
    Synonyms:Ptch
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 13

    Organism-specific databases

    MGIiMGI:105373. Ptch1.

    Subcellular locationi

    GO - Cellular componenti

    1. axonal growth cone Source: Ensembl
    2. caveola Source: Ensembl
    3. dendritic growth cone Source: Ensembl
    4. extracellular region Source: Roslin
    5. Golgi apparatus Source: Ensembl
    6. integral component of plasma membrane Source: MGI
    7. midbody Source: UniProtKB
    8. perinuclear region of cytoplasm Source: Ensembl
    9. plasma membrane Source: BHF-UCL
    10. postsynaptic density Source: Ensembl
    11. primary cilium Source: MGI

    Keywords - Cellular componenti

    Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 14341434Protein patched homolog 1PRO_0000205965Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi127 – 1271N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi298 – 2981N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi335 – 3351N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi400 – 4001N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi861 – 8611N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi986 – 9861N-linked (GlcNAc...)Sequence Analysis

    Post-translational modificationi

    Glycosylation is necessary for SHH binding.By similarity

    Keywords - PTMi

    Glycoprotein

    Proteomic databases

    PRIDEiQ61115.

    PTM databases

    PhosphoSiteiQ61115.

    Expressioni

    Developmental stagei

    Expressed at low level at 7 dpc, higher level at 11 and 15 dpc, and persists at moderate levels at 17 dpc. In the developing embryo, PTC is first detected within the ventral neural tube and later in the somites and limb buds. Expression in the limb buds is restricted to the posterior ectoderm surrounding the zone of polarizing activity. In the adult, expression is seen in brain, lung, liver, kidney and ocular tissues; lower levels in heart, skeletal muscle, and testis.

    Inductioni

    Activated by Sonic hedgehog.

    Gene expression databases

    ArrayExpressiQ61115.
    BgeeiQ61115.
    CleanExiMM_PTCH1.
    GenevestigatoriQ61115.

    Interactioni

    Subunit structurei

    Interacts with SNX17 By similarity. Interacts with IHH.By similarity1 Publication

    Protein-protein interaction databases

    DIPiDIP-60268N.

    Structurei

    3D structure databases

    ProteinModelPortaliQ61115.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 8686CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini108 – 422315ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini444 – 45815CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini480 – 4878ExtracellularSequence Analysis
    Topological domaini509 – 53325CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini555 – 5639ExtracellularSequence Analysis
    Topological domaini585 – 734150CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini756 – 1013258ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini1035 – 10395CytoplasmicSequence Analysis
    Topological domaini1061 – 10699ExtracellularSequence Analysis
    Topological domaini1091 – 110717CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini1129 – 114012ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini1162 – 1434273CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei87 – 10721HelicalSequence AnalysisAdd
    BLAST
    Transmembranei423 – 44321HelicalSequence AnalysisAdd
    BLAST
    Transmembranei459 – 47921HelicalSequence AnalysisAdd
    BLAST
    Transmembranei488 – 50821HelicalSequence AnalysisAdd
    BLAST
    Transmembranei534 – 55421HelicalSequence AnalysisAdd
    BLAST
    Transmembranei564 – 58421HelicalSequence AnalysisAdd
    BLAST
    Transmembranei735 – 75521HelicalSequence AnalysisAdd
    BLAST
    Transmembranei1014 – 103421HelicalSequence AnalysisAdd
    BLAST
    Transmembranei1040 – 106021HelicalSequence AnalysisAdd
    BLAST
    Transmembranei1070 – 109021HelicalSequence AnalysisAdd
    BLAST
    Transmembranei1108 – 112821HelicalSequence AnalysisAdd
    BLAST
    Transmembranei1141 – 116121HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini424 – 584161SSDPROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Belongs to the patched family.Curated
    Contains 1 SSD (sterol-sensing) domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG313603.
    GeneTreeiENSGT00680000099777.
    HOGENOMiHOG000231331.
    HOVERGENiHBG003801.
    InParanoidiQ61115.
    KOiK06225.
    OMAiPDRDYLH.
    OrthoDBiEOG7HMS06.
    PhylomeDBiQ61115.
    TreeFamiTF106489.

    Family and domain databases

    InterProiIPR003392. Patched.
    IPR000731. SSD.
    IPR004766. TM_rcpt_patched.
    [Graphical view]
    PfamiPF02460. Patched. 1 hit.
    [Graphical view]
    TIGRFAMsiTIGR00918. 2A060602. 1 hit.
    PROSITEiPS50156. SSD. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q61115-1 [UniParc]FASTAAdd to Basket

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    MASAGNAAGA LGRQAGGGRR RRTGGPHRAA PDRDYLHRPS YCDAAFALEQ     50
    ISKGKATGRK APLWLRAKFQ RLLFKLGCYI QKNCGKFLVV GLLIFGAFAV 100
    GLKAANLETN VEELWVEVGG RVSRELNYTR QKIGEEAMFN PQLMIQTPKE 150
    EGANVLTTEA LLQHLDSALQ ASRVHVYMYN RQWKLEHLCY KSGELITETG 200
    YMDQIIEYLY PCLIITPLDC FWEGAKLQSG TAYLLGKPPL RWTNFDPLEF 250
    LEELKKINYQ VDSWEEMLNK AEVGHGYMDR PCLNPADPDC PATAPNKNST 300
    KPLDVALVLN GGCQGLSRKY MHWQEELIVG GTVKNATGKL VSAHALQTMF 350
    QLMTPKQMYE HFRGYDYVSH INWNEDRAAA ILEAWQRTYV EVVHQSVAPN 400
    STQKVLPFTT TTLDDILKSF SDVSVIRVAS GYLLMLAYAC LTMLRWDCSK 450
    SQGAVGLAGV LLVALSVAAG LGLCSLIGIS FNAATTQVLP FLALGVGVDD 500
    VFLLAHAFSE TGQNKRIPFE DRTGECLKRT GASVALTSIS NVTAFFMAAL 550
    IPIPALRAFS LQAAVVVVFN FAMVLLIFPA ILSMDLYRRE DRRLDIFCCF 600
    TSPCVSRVIQ VEPQAYTEPH SNTRYSPPPP YTSHSFAHET HITMQSTVQL 650
    RTEYDPHTHV YYTTAEPRSE ISVQPVTVTQ DNLSCQSPES TSSTRDLLSQ 700
    FSDSSLHCLE PPCTKWTLSS FAEKHYAPFL LKPKAKVVVI LLFLGLLGVS 750
    LYGTTRVRDG LDLTDIVPRE TREYDFIAAQ FKYFSFYNMY IVTQKADYPN 800
    IQHLLYDLHK SFSNVKYVML EENKQLPQMW LHYFRDWLQG LQDAFDSDWE 850
    TGRIMPNNYK NGSDDGVLAY KLLVQTGSRD KPIDISQLTK QRLVDADGII 900
    NPSAFYIYLT AWVSNDPVAY AASQANIRPH RPEWVHDKAD YMPETRLRIP 950
    AAEPIEYAQF PFYLNGLRDT SDFVEAIEKV RVICNNYTSL GLSSYPNGYP 1000
    FLFWEQYISL RHWLLLSISV VLACTFLVCA VFLLNPWTAG IIVMVLALMT 1050
    VELFGMMGLI GIKLSAVPVV ILIASVGIGV EFTVHVALAF LTAIGDKNHR 1100
    AMLALEHMFA PVLDGAVSTL LGVLMLAGSE FDFIVRYFFA VLAILTVLGV 1150
    LNGLVLLPVL LSFFGPCPEV SPANGLNRLP TPSPEPPPSV VRFAVPPGHT 1200
    NNGSDSSDSE YSSQTTVSGI SEELRQYEAQ QGAGGPAHQV IVEATENPVF 1250
    ARSTVVHPDS RHQPPLTPRQ QPHLDSGSLS PGRQGQQPRR DPPREGLRPP 1300
    PYRPRRDAFE ISTEGHSGPS NRDRSGPRGA RSHNPRNPTS TAMGSSVPSY 1350
    CQPITTVTAS ASVTVAVHPP PGPGRNPRGG PCPGYESYPE TDHGVFEDPH 1400
    VPFHVRCERR DSKVEVIELQ DVECEERPWG SSSN 1434
    Length:1,434
    Mass (Da):159,273
    Last modified:November 1, 1996 - v1
    Checksum:iA5E9189E633173D0
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U46155 mRNA. Translation: AAC98798.1.
    CCDSiCCDS26592.1.
    PIRiT30172.
    RefSeqiNP_032983.1. NM_008957.2.
    XP_006517222.1. XM_006517159.1.
    UniGeneiMm.228798.
    Mm.488634.

    Genome annotation databases

    EnsembliENSMUST00000021921; ENSMUSP00000021921; ENSMUSG00000021466.
    GeneIDi19206.
    KEGGimmu:19206.
    UCSCiuc007qxv.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U46155 mRNA. Translation: AAC98798.1 .
    CCDSi CCDS26592.1.
    PIRi T30172.
    RefSeqi NP_032983.1. NM_008957.2.
    XP_006517222.1. XM_006517159.1.
    UniGenei Mm.228798.
    Mm.488634.

    3D structure databases

    ProteinModelPortali Q61115.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    DIPi DIP-60268N.

    PTM databases

    PhosphoSitei Q61115.

    Proteomic databases

    PRIDEi Q61115.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000021921 ; ENSMUSP00000021921 ; ENSMUSG00000021466 .
    GeneIDi 19206.
    KEGGi mmu:19206.
    UCSCi uc007qxv.1. mouse.

    Organism-specific databases

    CTDi 5727.
    MGIi MGI:105373. Ptch1.

    Phylogenomic databases

    eggNOGi NOG313603.
    GeneTreei ENSGT00680000099777.
    HOGENOMi HOG000231331.
    HOVERGENi HBG003801.
    InParanoidi Q61115.
    KOi K06225.
    OMAi PDRDYLH.
    OrthoDBi EOG7HMS06.
    PhylomeDBi Q61115.
    TreeFami TF106489.

    Miscellaneous databases

    NextBioi 295938.
    PROi Q61115.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q61115.
    Bgeei Q61115.
    CleanExi MM_PTCH1.
    Genevestigatori Q61115.

    Family and domain databases

    InterProi IPR003392. Patched.
    IPR000731. SSD.
    IPR004766. TM_rcpt_patched.
    [Graphical view ]
    Pfami PF02460. Patched. 1 hit.
    [Graphical view ]
    TIGRFAMsi TIGR00918. 2A060602. 1 hit.
    PROSITEi PS50156. SSD. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Conservation of the hedgehog/patched signaling pathway from flies to mice: induction of a mouse patched gene by Hedgehog."
      Goodrich L.V., Johnson R.L., Milenkovic L., McMahon J.A., Scott M.P.
      Genes Dev. 10:301-312(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Embryo.
    2. "Indian hedgehog mutations causing brachydactyly type A1 impair Hedgehog signal transduction at multiple levels."
      Ma G., Yu J., Xiao Y., Chan D., Gao B., Hu J., He Y., Guo S., Zhou J., Zhang L., Gao L., Zhang W., Kang Y., Cheah K.S., Feng G., Guo X., Wang Y., Zhou C.Z., He L.
      Cell Res. 21:1343-1357(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, INTERACTION WITH IHH.

    Entry informationi

    Entry nameiPTC1_MOUSE
    AccessioniPrimary (citable) accession number: Q61115
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 30, 2000
    Last sequence update: November 1, 1996
    Last modified: October 1, 2014
    This is version 119 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3