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Q61115

- PTC1_MOUSE

UniProt

Q61115 - PTC1_MOUSE

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Protein
Protein patched homolog 1
Gene
Ptch1, Ptch
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Acts as a receptor for sonic hedgehog (SHH), indian hedgehog (IHH) and desert hedgehog (DHH). Associates with the smoothened protein (SMO) to transduce the hedgehog's proteins signal. Seems to have a tumor suppressor function, as inactivation of this protein is probably a necessary, if not sufficient step for tumorigenesis.1 Publication

GO - Molecular functioni

  1. cholesterol binding Source: Roslin
  2. cyclin binding Source: BHF-UCL
  3. hedgehog receptor activity Source: MGI
  4. heparin binding Source: Roslin
  5. patched binding Source: Roslin
  6. protein binding Source: UniProtKB
  7. protein complex binding Source: BHF-UCL
  8. zinc ion binding Source: Roslin

GO - Biological processi

  1. brain development Source: BHF-UCL
  2. branching involved in ureteric bud morphogenesis Source: MGI
  3. cell differentiation involved in kidney development Source: MGI
  4. cell proliferation involved in metanephros development Source: MGI
  5. cellular response to cholesterol Source: BHF-UCL
  6. dorsal/ventral neural tube patterning Source: MGI
  7. dorsal/ventral pattern formation Source: MGI
  8. embryonic limb morphogenesis Source: MGI
  9. embryonic organ development Source: MGI
  10. epidermis development Source: MGI
  11. glucose homeostasis Source: MGI
  12. heart morphogenesis Source: MGI
  13. hindlimb morphogenesis Source: MGI
  14. in utero embryonic development Source: MGI
  15. keratinocyte proliferation Source: MGI
  16. mammary gland development Source: MGI
  17. mammary gland duct morphogenesis Source: MGI
  18. mammary gland epithelial cell differentiation Source: MGI
  19. negative regulation of cell division Source: BHF-UCL
  20. negative regulation of cell proliferation Source: BHF-UCL
  21. negative regulation of epithelial cell proliferation Source: MGI
  22. negative regulation of multicellular organism growth Source: MGI
  23. negative regulation of osteoblast differentiation Source: Ensembl
  24. negative regulation of sequence-specific DNA binding transcription factor activity Source: Ensembl
  25. negative regulation of smoothened signaling pathway Source: BHF-UCL
  26. negative regulation of transcription from RNA polymerase II promoter Source: Ensembl
  27. neural plate axis specification Source: BHF-UCL
  28. neural tube closure Source: MGI
  29. neural tube formation Source: Roslin
  30. organ morphogenesis Source: MGI
  31. pattern specification process Source: MGI
  32. pharyngeal system development Source: Ensembl
  33. positive regulation of cholesterol efflux Source: Ensembl
  34. protein processing Source: MGI
  35. protein targeting to plasma membrane Source: Ensembl
  36. regulation of cell proliferation Source: MGI
  37. regulation of growth Source: MGI
  38. regulation of mitotic cell cycle Source: MGI
  39. regulation of protein localization Source: BHF-UCL
  40. regulation of smoothened signaling pathway Source: MGI
  41. response to chlorate Source: MGI
  42. response to drug Source: Ensembl
  43. response to estradiol Source: Ensembl
  44. response to mechanical stimulus Source: Ensembl
  45. response to retinoic acid Source: Ensembl
  46. signal transduction Source: Roslin
  47. smoothened signaling pathway Source: MGI
  48. smoothened signaling pathway involved in dorsal/ventral neural tube patterning Source: MGI
  49. somite development Source: BHF-UCL
  50. spinal cord motor neuron differentiation Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

Receptor

Names & Taxonomyi

Protein namesi
Recommended name:
Protein patched homolog 1
Short name:
PTC
Short name:
PTC1
Gene namesi
Name:Ptch1
Synonyms:Ptch
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 13

Organism-specific databases

MGIiMGI:105373. Ptch1.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 8686Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei87 – 10721Helical; Reviewed prediction
Add
BLAST
Topological domaini108 – 422315Extracellular Reviewed prediction
Add
BLAST
Transmembranei423 – 44321Helical; Reviewed prediction
Add
BLAST
Topological domaini444 – 45815Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei459 – 47921Helical; Reviewed prediction
Add
BLAST
Topological domaini480 – 4878Extracellular Reviewed prediction
Transmembranei488 – 50821Helical; Reviewed prediction
Add
BLAST
Topological domaini509 – 53325Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei534 – 55421Helical; Reviewed prediction
Add
BLAST
Topological domaini555 – 5639Extracellular Reviewed prediction
Transmembranei564 – 58421Helical; Reviewed prediction
Add
BLAST
Topological domaini585 – 734150Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei735 – 75521Helical; Reviewed prediction
Add
BLAST
Topological domaini756 – 1013258Extracellular Reviewed prediction
Add
BLAST
Transmembranei1014 – 103421Helical; Reviewed prediction
Add
BLAST
Topological domaini1035 – 10395Cytoplasmic Reviewed prediction
Transmembranei1040 – 106021Helical; Reviewed prediction
Add
BLAST
Topological domaini1061 – 10699Extracellular Reviewed prediction
Transmembranei1070 – 109021Helical; Reviewed prediction
Add
BLAST
Topological domaini1091 – 110717Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei1108 – 112821Helical; Reviewed prediction
Add
BLAST
Topological domaini1129 – 114012Extracellular Reviewed prediction
Add
BLAST
Transmembranei1141 – 116121Helical; Reviewed prediction
Add
BLAST
Topological domaini1162 – 1434273Cytoplasmic Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. Golgi apparatus Source: Ensembl
  2. axonal growth cone Source: Ensembl
  3. caveola Source: Ensembl
  4. dendritic growth cone Source: Ensembl
  5. extracellular region Source: Roslin
  6. integral component of plasma membrane Source: MGI
  7. midbody Source: UniProtKB
  8. perinuclear region of cytoplasm Source: Ensembl
  9. plasma membrane Source: BHF-UCL
  10. postsynaptic density Source: Ensembl
  11. primary cilium Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 14341434Protein patched homolog 1
PRO_0000205965Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi127 – 1271N-linked (GlcNAc...) Reviewed prediction
Glycosylationi298 – 2981N-linked (GlcNAc...) Reviewed prediction
Glycosylationi335 – 3351N-linked (GlcNAc...) Reviewed prediction
Glycosylationi400 – 4001N-linked (GlcNAc...) Reviewed prediction
Glycosylationi861 – 8611N-linked (GlcNAc...) Reviewed prediction
Glycosylationi986 – 9861N-linked (GlcNAc...) Reviewed prediction

Post-translational modificationi

Glycosylation is necessary for SHH binding By similarity.

Keywords - PTMi

Glycoprotein

Proteomic databases

PRIDEiQ61115.

PTM databases

PhosphoSiteiQ61115.

Expressioni

Developmental stagei

Expressed at low level at 7 dpc, higher level at 11 and 15 dpc, and persists at moderate levels at 17 dpc. In the developing embryo, PTC is first detected within the ventral neural tube and later in the somites and limb buds. Expression in the limb buds is restricted to the posterior ectoderm surrounding the zone of polarizing activity. In the adult, expression is seen in brain, lung, liver, kidney and ocular tissues; lower levels in heart, skeletal muscle, and testis.

Inductioni

Activated by Sonic hedgehog.

Gene expression databases

ArrayExpressiQ61115.
BgeeiQ61115.
CleanExiMM_PTCH1.
GenevestigatoriQ61115.

Interactioni

Subunit structurei

Interacts with SNX17 By similarity. Interacts with IHH.1 Publication

Protein-protein interaction databases

DIPiDIP-60268N.

Structurei

3D structure databases

ProteinModelPortaliQ61115.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini424 – 584161SSD
Add
BLAST

Sequence similaritiesi

Belongs to the patched family.

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG313603.
GeneTreeiENSGT00680000099777.
HOGENOMiHOG000231331.
HOVERGENiHBG003801.
InParanoidiQ61115.
KOiK06225.
OMAiPDRDYLH.
OrthoDBiEOG7HMS06.
PhylomeDBiQ61115.
TreeFamiTF106489.

Family and domain databases

InterProiIPR003392. Patched.
IPR000731. SSD.
IPR004766. TM_rcpt_patched.
[Graphical view]
PfamiPF02460. Patched. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00918. 2A060602. 1 hit.
PROSITEiPS50156. SSD. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q61115-1 [UniParc]FASTAAdd to Basket

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MASAGNAAGA LGRQAGGGRR RRTGGPHRAA PDRDYLHRPS YCDAAFALEQ     50
ISKGKATGRK APLWLRAKFQ RLLFKLGCYI QKNCGKFLVV GLLIFGAFAV 100
GLKAANLETN VEELWVEVGG RVSRELNYTR QKIGEEAMFN PQLMIQTPKE 150
EGANVLTTEA LLQHLDSALQ ASRVHVYMYN RQWKLEHLCY KSGELITETG 200
YMDQIIEYLY PCLIITPLDC FWEGAKLQSG TAYLLGKPPL RWTNFDPLEF 250
LEELKKINYQ VDSWEEMLNK AEVGHGYMDR PCLNPADPDC PATAPNKNST 300
KPLDVALVLN GGCQGLSRKY MHWQEELIVG GTVKNATGKL VSAHALQTMF 350
QLMTPKQMYE HFRGYDYVSH INWNEDRAAA ILEAWQRTYV EVVHQSVAPN 400
STQKVLPFTT TTLDDILKSF SDVSVIRVAS GYLLMLAYAC LTMLRWDCSK 450
SQGAVGLAGV LLVALSVAAG LGLCSLIGIS FNAATTQVLP FLALGVGVDD 500
VFLLAHAFSE TGQNKRIPFE DRTGECLKRT GASVALTSIS NVTAFFMAAL 550
IPIPALRAFS LQAAVVVVFN FAMVLLIFPA ILSMDLYRRE DRRLDIFCCF 600
TSPCVSRVIQ VEPQAYTEPH SNTRYSPPPP YTSHSFAHET HITMQSTVQL 650
RTEYDPHTHV YYTTAEPRSE ISVQPVTVTQ DNLSCQSPES TSSTRDLLSQ 700
FSDSSLHCLE PPCTKWTLSS FAEKHYAPFL LKPKAKVVVI LLFLGLLGVS 750
LYGTTRVRDG LDLTDIVPRE TREYDFIAAQ FKYFSFYNMY IVTQKADYPN 800
IQHLLYDLHK SFSNVKYVML EENKQLPQMW LHYFRDWLQG LQDAFDSDWE 850
TGRIMPNNYK NGSDDGVLAY KLLVQTGSRD KPIDISQLTK QRLVDADGII 900
NPSAFYIYLT AWVSNDPVAY AASQANIRPH RPEWVHDKAD YMPETRLRIP 950
AAEPIEYAQF PFYLNGLRDT SDFVEAIEKV RVICNNYTSL GLSSYPNGYP 1000
FLFWEQYISL RHWLLLSISV VLACTFLVCA VFLLNPWTAG IIVMVLALMT 1050
VELFGMMGLI GIKLSAVPVV ILIASVGIGV EFTVHVALAF LTAIGDKNHR 1100
AMLALEHMFA PVLDGAVSTL LGVLMLAGSE FDFIVRYFFA VLAILTVLGV 1150
LNGLVLLPVL LSFFGPCPEV SPANGLNRLP TPSPEPPPSV VRFAVPPGHT 1200
NNGSDSSDSE YSSQTTVSGI SEELRQYEAQ QGAGGPAHQV IVEATENPVF 1250
ARSTVVHPDS RHQPPLTPRQ QPHLDSGSLS PGRQGQQPRR DPPREGLRPP 1300
PYRPRRDAFE ISTEGHSGPS NRDRSGPRGA RSHNPRNPTS TAMGSSVPSY 1350
CQPITTVTAS ASVTVAVHPP PGPGRNPRGG PCPGYESYPE TDHGVFEDPH 1400
VPFHVRCERR DSKVEVIELQ DVECEERPWG SSSN 1434
Length:1,434
Mass (Da):159,273
Last modified:November 1, 1996 - v1
Checksum:iA5E9189E633173D0
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U46155 mRNA. Translation: AAC98798.1.
CCDSiCCDS26592.1.
PIRiT30172.
RefSeqiNP_032983.1. NM_008957.2.
XP_006517222.1. XM_006517159.1.
UniGeneiMm.228798.
Mm.488634.

Genome annotation databases

EnsembliENSMUST00000021921; ENSMUSP00000021921; ENSMUSG00000021466.
GeneIDi19206.
KEGGimmu:19206.
UCSCiuc007qxv.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U46155 mRNA. Translation: AAC98798.1 .
CCDSi CCDS26592.1.
PIRi T30172.
RefSeqi NP_032983.1. NM_008957.2.
XP_006517222.1. XM_006517159.1.
UniGenei Mm.228798.
Mm.488634.

3D structure databases

ProteinModelPortali Q61115.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

DIPi DIP-60268N.

PTM databases

PhosphoSitei Q61115.

Proteomic databases

PRIDEi Q61115.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000021921 ; ENSMUSP00000021921 ; ENSMUSG00000021466 .
GeneIDi 19206.
KEGGi mmu:19206.
UCSCi uc007qxv.1. mouse.

Organism-specific databases

CTDi 5727.
MGIi MGI:105373. Ptch1.

Phylogenomic databases

eggNOGi NOG313603.
GeneTreei ENSGT00680000099777.
HOGENOMi HOG000231331.
HOVERGENi HBG003801.
InParanoidi Q61115.
KOi K06225.
OMAi PDRDYLH.
OrthoDBi EOG7HMS06.
PhylomeDBi Q61115.
TreeFami TF106489.

Miscellaneous databases

NextBioi 295938.
PROi Q61115.
SOURCEi Search...

Gene expression databases

ArrayExpressi Q61115.
Bgeei Q61115.
CleanExi MM_PTCH1.
Genevestigatori Q61115.

Family and domain databases

InterProi IPR003392. Patched.
IPR000731. SSD.
IPR004766. TM_rcpt_patched.
[Graphical view ]
Pfami PF02460. Patched. 1 hit.
[Graphical view ]
TIGRFAMsi TIGR00918. 2A060602. 1 hit.
PROSITEi PS50156. SSD. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Conservation of the hedgehog/patched signaling pathway from flies to mice: induction of a mouse patched gene by Hedgehog."
    Goodrich L.V., Johnson R.L., Milenkovic L., McMahon J.A., Scott M.P.
    Genes Dev. 10:301-312(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Embryo.
  2. "Indian hedgehog mutations causing brachydactyly type A1 impair Hedgehog signal transduction at multiple levels."
    Ma G., Yu J., Xiao Y., Chan D., Gao B., Hu J., He Y., Guo S., Zhou J., Zhang L., Gao L., Zhang W., Kang Y., Cheah K.S., Feng G., Guo X., Wang Y., Zhou C.Z., He L.
    Cell Res. 21:1343-1357(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, INTERACTION WITH IHH.

Entry informationi

Entry nameiPTC1_MOUSE
AccessioniPrimary (citable) accession number: Q61115
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: November 1, 1996
Last modified: September 3, 2014
This is version 118 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi