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Protein

BPI fold-containing family B member 1

Gene

Bpifb1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

May play a role in innate immunity in mouth, nose and lungs. Binds bacterial lipopolysaccharide (LPS) and modulates the cellular responses to LPS. May be involved in formation of the left-right axis in the node of the developing embryo.2 Publications

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Immunity, Innate immunity

Names & Taxonomyi

Protein namesi
Recommended name:
BPI fold-containing family B member 1
Alternative name(s):
Long palate, lung and nasal epithelium carcinoma-associated protein 1
Gene namesi
Name:Bpifb1
Synonyms:Lplunc1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 2

Organism-specific databases

MGIiMGI:2137431. Bpifb1.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2121Sequence analysisAdd
BLAST
Chaini22 – 474453BPI fold-containing family B member 1PRO_0000017181Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi153 – 1531N-linked (GlcNAc...)Sequence analysis
Disulfide bondi157 ↔ 200By similarity
Glycosylationi160 – 1601N-linked (GlcNAc...)Sequence analysis
Glycosylationi263 – 2631N-linked (GlcNAc...)Sequence analysis
Glycosylationi400 – 4001N-linked (GlcNAc...)Sequence analysis

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

MaxQBiQ61114.
PaxDbiQ61114.
PRIDEiQ61114.

PTM databases

PhosphoSiteiQ61114.

Expressioni

Tissue specificityi

Expressed in tongue, lung, thymus, and stomach. Expressed in epithelia of palate, anterior pharynx, trachea and upper bronchi. Expressed in distal tip of papillae in the anterior third of the tongue and in serous cells of von Ebner glands in the posterior third of the tongue. Expressed in columnar epithelium of the duodenum in embryonic gut at 16.5 dpc.2 Publications

Developmental stagei

Detectable in crown cells of the embryonic node from E7.5. Initial uniform expression develops asymmetrically with a higher level on the left side of the node until expression disappears around E13.5. Expressed in antrum pyloricum of the stomach from E11.5 to E16.5 and in dorsal tongue epithelium from E14.5 to E16.5.1 Publication

Gene expression databases

BgeeiQ61114.
CleanExiMM_U46068.
GenevisibleiQ61114. MM.

Interactioni

Protein-protein interaction databases

IntActiQ61114. 1 interaction.
MINTiMINT-4100531.
STRINGi10090.ENSMUSP00000028987.

Structurei

3D structure databases

ProteinModelPortaliQ61114.
SMRiQ61114. Positions 52-207.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the BPI/LBP/Plunc superfamily. Plunc family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG4160. Eukaryota.
ENOG410Z88E. LUCA.
GeneTreeiENSGT00840000130012.
HOGENOMiHOG000231564.
HOVERGENiHBG052339.
InParanoidiQ61114.
OMAiSDRIHLM.
OrthoDBiEOG7VB2FG.
PhylomeDBiQ61114.
TreeFamiTF338541.

Family and domain databases

InterProiIPR017943. Bactericidal_perm-incr_a/b_dom.
IPR032942. BPI/LBP/Plunc.
IPR021193. Bpifb1.
IPR001124. Lipid-bd_serum_glycop_C.
IPR017942. Lipid-bd_serum_glycop_N.
[Graphical view]
PANTHERiPTHR10504. PTHR10504. 1 hit.
PTHR10504:SF21. PTHR10504:SF21. 1 hit.
PfamiPF01273. LBP_BPI_CETP. 1 hit.
PF02886. LBP_BPI_CETP_C. 1 hit.
[Graphical view]
PIRSFiPIRSF037186. PLUNC_long_form. 1 hit.
SMARTiSM00328. BPI1. 1 hit.
[Graphical view]
SUPFAMiSSF55394. SSF55394. 2 hits.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q61114-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAGPWIITLL CGLLGATLVQ ANVYPPAVLN LGPEVIQKHL TQALKDHDAT
60 70 80 90 100
AILQELPLLR AMQDKSGSIP ILDSFVHTVL RYIIWMKVTS ANILQLDVQP
110 120 130 140 150
STYDQELVVR IPLDMVAGLN TPLIKTIVEF QMSTEVQALI RVERSKSGPA
160 170 180 190 200
HLNLSDCSSN ESTLRLSLLH KLSFVVNSLA KNVMNLLVPA LPQIVKNHLC
210 220 230 240 250
PVIQQAFDDM YEDFLRLTTA PIALSPGALE FGLLSPAIQD SNILLNLKAK
260 270 280 290 300
LLDSQARVTN WFNNSATSLM ETTPDRAPFS LTVRQDLVNA IVTTLVPKEE
310 320 330 340 350
LVILLRFVIP DVARQLQMDI KEINAEAANK LGPTQMLKIF THSTPHIVLN
360 370 380 390 400
EGSARAAQSV VLEVFPTNTD VRPFFSLGIE ASYEAQFFTE DNRLMLNFNN
410 420 430 440 450
VSIERIKLMI SDIKLFDPEV LKDTLTKILE YTLLPNENGK LRTGVPMSMS
460 470
KALGYEKAMW SVSKGALKLT PASS
Length:474
Mass (Da):52,455
Last modified:May 2, 2006 - v4
Checksum:i4CDF2CB13BA4F57A
GO

Sequence cautioni

The sequence AAA87581.3 differs from that shown. Reason: Frameshift at position 69. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti137 – 1371Q → R in AAH60982 (PubMed:15489334).Curated
Sequence conflicti361 – 3611V → M in AAH60982 (PubMed:15489334).Curated
Sequence conflicti395 – 3951M → T in AAI00437 (PubMed:15489334).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U46068 mRNA. Translation: AAA87581.3. Frameshift.
AL732601 Genomic DNA. Translation: CAM15619.1.
BC060982 mRNA. Translation: AAH60982.1.
BC100436 mRNA. Translation: AAI00437.1.
CCDSiCCDS16927.1.
RefSeqiNP_001012392.1. NM_001012392.1.
NP_700467.2. NM_153418.2.
UniGeneiMm.3783.

Genome annotation databases

EnsembliENSMUST00000028987; ENSMUSP00000028987; ENSMUSG00000027485.
ENSMUST00000081816; ENSMUSP00000080501; ENSMUSG00000027485.
GeneIDi228801.
KEGGimmu:228801.
UCSCiuc008niw.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U46068 mRNA. Translation: AAA87581.3. Frameshift.
AL732601 Genomic DNA. Translation: CAM15619.1.
BC060982 mRNA. Translation: AAH60982.1.
BC100436 mRNA. Translation: AAI00437.1.
CCDSiCCDS16927.1.
RefSeqiNP_001012392.1. NM_001012392.1.
NP_700467.2. NM_153418.2.
UniGeneiMm.3783.

3D structure databases

ProteinModelPortaliQ61114.
SMRiQ61114. Positions 52-207.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ61114. 1 interaction.
MINTiMINT-4100531.
STRINGi10090.ENSMUSP00000028987.

PTM databases

PhosphoSiteiQ61114.

Proteomic databases

MaxQBiQ61114.
PaxDbiQ61114.
PRIDEiQ61114.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000028987; ENSMUSP00000028987; ENSMUSG00000027485.
ENSMUST00000081816; ENSMUSP00000080501; ENSMUSG00000027485.
GeneIDi228801.
KEGGimmu:228801.
UCSCiuc008niw.1. mouse.

Organism-specific databases

CTDi92747.
MGIiMGI:2137431. Bpifb1.

Phylogenomic databases

eggNOGiKOG4160. Eukaryota.
ENOG410Z88E. LUCA.
GeneTreeiENSGT00840000130012.
HOGENOMiHOG000231564.
HOVERGENiHBG052339.
InParanoidiQ61114.
OMAiSDRIHLM.
OrthoDBiEOG7VB2FG.
PhylomeDBiQ61114.
TreeFamiTF338541.

Miscellaneous databases

NextBioi379164.
PROiQ61114.
SOURCEiSearch...

Gene expression databases

BgeeiQ61114.
CleanExiMM_U46068.
GenevisibleiQ61114. MM.

Family and domain databases

InterProiIPR017943. Bactericidal_perm-incr_a/b_dom.
IPR032942. BPI/LBP/Plunc.
IPR021193. Bpifb1.
IPR001124. Lipid-bd_serum_glycop_C.
IPR017942. Lipid-bd_serum_glycop_N.
[Graphical view]
PANTHERiPTHR10504. PTHR10504. 1 hit.
PTHR10504:SF21. PTHR10504:SF21. 1 hit.
PfamiPF01273. LBP_BPI_CETP. 1 hit.
PF02886. LBP_BPI_CETP_C. 1 hit.
[Graphical view]
PIRSFiPIRSF037186. PLUNC_long_form. 1 hit.
SMARTiSM00328. BPI1. 1 hit.
[Graphical view]
SUPFAMiSSF55394. SSF55394. 2 hits.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Snead M.L., Villanueva J., Paine M.L., Lei Y.P., Zhu D.H., Lusis J., Xia Y.-R., Yang J.-N.
    Submitted (SEP-2002) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: Swiss Webster.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Heart and Lung.
  4. "Identification of a novel left-right asymmetrically expressed gene in the mouse belonging to the BPI/PLUNC superfamily."
    Hou J., Yashiro K., Okazaki Y., Saijoh Y., Hayashizaki Y., Hamada H.
    Dev. Dyn. 229:373-379(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, DEVELOPMENTAL STAGE.
  5. "Cloning and expression of a mouse member of the PLUNC protein family exclusively expressed in tongue epithelium."
    LeClair E.E., Nomellini V., Bahena M., Singleton V., Bingle L., Craven C.J., Bingle C.D.
    Genomics 83:658-666(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, TISSUE SPECIFICITY.

Entry informationi

Entry nameiBPIB1_MOUSE
AccessioniPrimary (citable) accession number: Q61114
Secondary accession number(s): A2AJD5, Q497Q1, Q4VC32
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 29, 2003
Last sequence update: May 2, 2006
Last modified: May 11, 2016
This is version 106 of the entry and version 4 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Miscellaneous

Asymmetric expression in the embryonic node is dependent on Invs and Dnahc11.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.