Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

ATP-binding cassette sub-family B member 7, mitochondrial

Gene

Abcb7

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Could be involved in the transport of heme from the mitochondria to the cytosol. Plays a central role in the maturation of cytosolic iron-sulfur (Fe/S) cluster-containing proteins (By similarity).By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei481 – 4811ATPBy similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi505 – 51612ATPPROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

  1. ATPase activity, coupled to transmembrane movement of substances Source: GO_Central
  2. ATP binding Source: UniProtKB-KW

GO - Biological processi

  1. cellular iron ion homeostasis Source: MGI
  2. transmembrane transport Source: GO_Central
Complete GO annotation...

Keywords - Biological processi

Transport

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiREACT_299576. Cytosolic iron-sulfur cluster assembly.
REACT_307155. Mitochondrial ABC transporters.

Names & Taxonomyi

Protein namesi
Recommended name:
ATP-binding cassette sub-family B member 7, mitochondrial
Alternative name(s):
ATP-binding cassette transporter 7
Short name:
ABC transporter 7 protein
Gene namesi
Name:Abcb7
Synonyms:Abc7
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589 Componenti: Chromosome X

Organism-specific databases

MGIiMGI:109533. Abcb7.

Subcellular locationi

Mitochondrion inner membrane Curated; Multi-pass membrane protein PROSITE-ProRule annotation

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei141 – 16121HelicalPROSITE-ProRule annotationAdd
BLAST
Transmembranei186 – 20621HelicalPROSITE-ProRule annotationAdd
BLAST
Transmembranei260 – 28021HelicalPROSITE-ProRule annotationAdd
BLAST
Transmembranei291 – 31121HelicalPROSITE-ProRule annotationAdd
BLAST
Transmembranei383 – 40321HelicalPROSITE-ProRule annotationAdd
BLAST
Transmembranei410 – 43021HelicalPROSITE-ProRule annotationAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: GO_Central
  2. mitochondrial inner membrane Source: MGI
  3. mitochondrion Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 752752ATP-binding cassette sub-family B member 7, mitochondrialPRO_0000093295Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei216 – 2161N6-acetyllysine1 Publication
Modified residuei251 – 2511N6-acetyllysine1 Publication
Modified residuei336 – 3361PhosphoserineBy similarity
Modified residuei340 – 3401PhosphotyrosineBy similarity
Modified residuei342 – 3421PhosphothreonineBy similarity
Modified residuei350 – 3501N6-acetyllysine1 Publication

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

MaxQBiQ61102.
PaxDbiQ61102.
PRIDEiQ61102.

PTM databases

PhosphoSiteiQ61102.

Expressioni

Gene expression databases

BgeeiQ61102.
GenevestigatoriQ61102.

Interactioni

Subunit structurei

Homodimer or heterodimer.Curated

Protein-protein interaction databases

IntActiQ61102. 3 interactions.
MINTiMINT-1861698.
STRINGi10090.ENSMUSP00000033695.

Structurei

3D structure databases

ProteinModelPortaliQ61102.
SMRiQ61102. Positions 127-737.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini140 – 436297ABC transmembrane type-1PROSITE-ProRule annotationAdd
BLAST
Domaini472 – 706235ABC transporterPROSITE-ProRule annotationAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi12 – 176Poly-Ala

Sequence similaritiesi

Contains 1 ABC transmembrane type-1 domain.PROSITE-ProRule annotation
Contains 1 ABC transporter domain.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG5265.
GeneTreeiENSGT00440000033373.
HOVERGENiHBG080194.
InParanoidiQ61102.
KOiK05662.
OMAiMMYLAAN.
OrthoDBiEOG7Z69BT.
TreeFamiTF105195.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR003593. AAA+_ATPase.
IPR011527. ABC1_TM_dom.
IPR003439. ABC_transporter-like.
IPR017871. ABC_transporter_CS.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF00664. ABC_membrane. 1 hit.
PF00005. ABC_tran. 1 hit.
[Graphical view]
SMARTiSM00382. AAA. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
SSF90123. SSF90123. 1 hit.
PROSITEiPS50929. ABC_TM1F. 1 hit.
PS00211. ABC_TRANSPORTER_1. 1 hit.
PS50893. ABC_TRANSPORTER_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q61102-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MALLAIHSWR WAAAAVAFEK HKHSAVLTRA LVSMCGSGPR WSSSQRGASG
60 70 80 90 100
SARLSQTTES LRNTTQQRWG KDNSRQLLDA TKALQTWPLI EKRTCWHGHA
110 120 130 140 150
GGGLHTDPKE GLKDVDTRKI IKAMLSYVWP EDRPDLRARV AISLGFLGGA
160 170 180 190 200
KAMNIVVPFM FKYAVDSLNQ MSGNMLNLSD APNTVATMAT AVLIGYGVSR
210 220 230 240 250
AGAAFFNEVR NAVFGKVAQN SIRRIAKNVF LHLHNLDLGF HLSRQTGALS
260 270 280 290 300
KAIDRGTRGI SFVLSALVFN LLPIVFEMML VSSVLYYKCG AQFALVTLGT
310 320 330 340 350
LGAYTAFTVA VTRWRTRFRI EMNKADNDAG NAAIDSLLNY ETVKYFNNEK
360 370 380 390 400
YEAQRYDGFL KTYETASLKS TSTLAMLNFG QNAIFSVGLT AIMVLASQGI
410 420 430 440 450
VAGALTVGDL VMVNGLLFQL SLPLNFLGTV YRETRQALID MNTLFTLLKV
460 470 480 490 500
DTRIKDKVMA PPLQITPQTA TVAFDNVHFE YIEGQKVLNG VSFEVPAGKK
510 520 530 540 550
VAIVGGSGSG KSTIVRLLFR FYEPQKGSIY LAGQNLQDVS LESLRRAVGV
560 570 580 590 600
VPQDAVLFHN TIYYNLLYGN INASPEEVYA VAKLAGLHDA ILRMPHGYDT
610 620 630 640 650
QVGERGLKLS GGEKQRVAIA RAILKNPPVI LYDEATSSLD SITEETILGA
660 670 680 690 700
MRDVVKHRTS IFIAHRLSTV VDADEIIVLS QGKVAERGTH YGLLANSSSI
710 720 730 740 750
YSEMWHTQSN RVQNQDSLGW DAKKESLSKE EERKKLQEEI VNSVKGCGNC

SC
Length:752
Mass (Da):82,581
Last modified:June 27, 2011 - v3
Checksum:i79B2BC8A7A07555A
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti702 – 7021S → T in BAE30838 (PubMed:16141072).Curated
Sequence conflicti702 – 7021S → T in BAE31291 (PubMed:16141072).Curated
Sequence conflicti702 – 7021S → T in BAE31519 (PubMed:16141072).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK151967 mRNA. Translation: BAE30838.1.
AK152535 mRNA. Translation: BAE31291.1.
AK152816 mRNA. Translation: BAE31519.1.
AL663052 Genomic DNA. Translation: CAM17389.1.
BC151037 mRNA. Translation: AAI51038.1.
U43892 mRNA. Translation: AAC53152.1.
CCDSiCCDS53167.1.
RefSeqiNP_033722.1. NM_009592.1.
UniGeneiMm.426128.

Genome annotation databases

EnsembliENSMUST00000033695; ENSMUSP00000033695; ENSMUSG00000031333.
GeneIDi11306.
KEGGimmu:11306.
UCSCiuc009uaf.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK151967 mRNA. Translation: BAE30838.1.
AK152535 mRNA. Translation: BAE31291.1.
AK152816 mRNA. Translation: BAE31519.1.
AL663052 Genomic DNA. Translation: CAM17389.1.
BC151037 mRNA. Translation: AAI51038.1.
U43892 mRNA. Translation: AAC53152.1.
CCDSiCCDS53167.1.
RefSeqiNP_033722.1. NM_009592.1.
UniGeneiMm.426128.

3D structure databases

ProteinModelPortaliQ61102.
SMRiQ61102. Positions 127-737.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ61102. 3 interactions.
MINTiMINT-1861698.
STRINGi10090.ENSMUSP00000033695.

PTM databases

PhosphoSiteiQ61102.

Proteomic databases

MaxQBiQ61102.
PaxDbiQ61102.
PRIDEiQ61102.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000033695; ENSMUSP00000033695; ENSMUSG00000031333.
GeneIDi11306.
KEGGimmu:11306.
UCSCiuc009uaf.2. mouse.

Organism-specific databases

CTDi22.
MGIiMGI:109533. Abcb7.

Phylogenomic databases

eggNOGiCOG5265.
GeneTreeiENSGT00440000033373.
HOVERGENiHBG080194.
InParanoidiQ61102.
KOiK05662.
OMAiMMYLAAN.
OrthoDBiEOG7Z69BT.
TreeFamiTF105195.

Enzyme and pathway databases

ReactomeiREACT_299576. Cytosolic iron-sulfur cluster assembly.
REACT_307155. Mitochondrial ABC transporters.

Miscellaneous databases

ChiTaRSiAbcb7. mouse.
NextBioi278598.
PROiQ61102.
SOURCEiSearch...

Gene expression databases

BgeeiQ61102.
GenevestigatoriQ61102.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR003593. AAA+_ATPase.
IPR011527. ABC1_TM_dom.
IPR003439. ABC_transporter-like.
IPR017871. ABC_transporter_CS.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF00664. ABC_membrane. 1 hit.
PF00005. ABC_tran. 1 hit.
[Graphical view]
SMARTiSM00382. AAA. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
SSF90123. SSF90123. 1 hit.
PROSITEiPS50929. ABC_TM1F. 1 hit.
PS00211. ABC_TRANSPORTER_1. 1 hit.
PS50893. ABC_TRANSPORTER_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Bone marrow.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain.
  4. "Isolation and chromosomal mapping of a novel ATP-binding cassette transporter conserved in mouse and human."
    Savary S., Allikmets R., Denizot F., Luciani M.-F., Mattei M.-G., Dean M., Chimini G.
    Genomics 41:275-278(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 59-752.
    Strain: DBA/2.
  5. "Label-free quantitative proteomics of the lysine acetylome in mitochondria identifies substrates of SIRT3 in metabolic pathways."
    Rardin M.J., Newman J.C., Held J.M., Cusack M.P., Sorensen D.J., Li B., Schilling B., Mooney S.D., Kahn C.R., Verdin E., Gibson B.W.
    Proc. Natl. Acad. Sci. U.S.A. 110:6601-6606(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-216; LYS-251 AND LYS-350, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Liver.

Entry informationi

Entry nameiABCB7_MOUSE
AccessioniPrimary (citable) accession number: Q61102
Secondary accession number(s): A2AC46, Q3U7S8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 14, 1998
Last sequence update: June 27, 2011
Last modified: March 31, 2015
This is version 127 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.