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Q61102

- ABCB7_MOUSE

UniProt

Q61102 - ABCB7_MOUSE

Protein

ATP-binding cassette sub-family B member 7, mitochondrial

Gene

Abcb7

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 121 (01 Oct 2014)
      Sequence version 3 (28 Jun 2011)
      Previous versions | rss
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    Functioni

    Could be involved in the transport of heme from the mitochondria to the cytosol. Plays a central role in the maturation of cytosolic iron-sulfur (Fe/S) cluster-containing proteins By similarity.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei481 – 4811ATPBy similarity

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi505 – 51612ATPPROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. ATPase activity, coupled to transmembrane movement of substances Source: RefGenome
    2. ATP binding Source: UniProtKB-KW

    GO - Biological processi

    1. cellular iron ion homeostasis Source: MGI
    2. transmembrane transport Source: RefGenome

    Keywords - Biological processi

    Transport

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    ReactomeiREACT_196637. Cytosolic iron-sulfur cluster assembly.
    REACT_197885. Mitochondrial ABC transporters.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    ATP-binding cassette sub-family B member 7, mitochondrial
    Alternative name(s):
    ATP-binding cassette transporter 7
    Short name:
    ABC transporter 7 protein
    Gene namesi
    Name:Abcb7
    Synonyms:Abc7
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome X

    Organism-specific databases

    MGIiMGI:109533. Abcb7.

    Subcellular locationi

    Mitochondrion inner membrane Curated; Multi-pass membrane protein PROSITE-ProRule annotation

    GO - Cellular componenti

    1. integral component of membrane Source: RefGenome
    2. mitochondrial inner membrane Source: MGI
    3. mitochondrion Source: MGI

    Keywords - Cellular componenti

    Membrane, Mitochondrion, Mitochondrion inner membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 752752ATP-binding cassette sub-family B member 7, mitochondrialPRO_0000093295Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei216 – 2161N6-acetyllysine1 Publication
    Modified residuei251 – 2511N6-acetyllysine1 Publication
    Modified residuei336 – 3361PhosphoserineBy similarity
    Modified residuei340 – 3401PhosphotyrosineBy similarity
    Modified residuei342 – 3421PhosphothreonineBy similarity
    Modified residuei350 – 3501N6-acetyllysine1 Publication

    Keywords - PTMi

    Acetylation, Phosphoprotein

    Proteomic databases

    MaxQBiQ61102.
    PaxDbiQ61102.
    PRIDEiQ61102.

    PTM databases

    PhosphoSiteiQ61102.

    Expressioni

    Gene expression databases

    BgeeiQ61102.
    GenevestigatoriQ61102.

    Interactioni

    Subunit structurei

    Homodimer or heterodimer.Curated

    Protein-protein interaction databases

    IntActiQ61102. 3 interactions.
    MINTiMINT-1861698.
    STRINGi10090.ENSMUSP00000033695.

    Structurei

    3D structure databases

    ProteinModelPortaliQ61102.
    SMRiQ61102. Positions 127-737.
    ModBaseiSearch...
    MobiDBiSearch...

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei141 – 16121HelicalPROSITE-ProRule annotationAdd
    BLAST
    Transmembranei186 – 20621HelicalPROSITE-ProRule annotationAdd
    BLAST
    Transmembranei260 – 28021HelicalPROSITE-ProRule annotationAdd
    BLAST
    Transmembranei291 – 31121HelicalPROSITE-ProRule annotationAdd
    BLAST
    Transmembranei383 – 40321HelicalPROSITE-ProRule annotationAdd
    BLAST
    Transmembranei410 – 43021HelicalPROSITE-ProRule annotationAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini140 – 436297ABC transmembrane type-1PROSITE-ProRule annotationAdd
    BLAST
    Domaini472 – 706235ABC transporterPROSITE-ProRule annotationAdd
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi12 – 176Poly-Ala

    Sequence similaritiesi

    Contains 1 ABC transmembrane type-1 domain.PROSITE-ProRule annotation
    Contains 1 ABC transporter domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG5265.
    GeneTreeiENSGT00440000033373.
    HOVERGENiHBG080194.
    InParanoidiA2AC46.
    KOiK05662.
    OMAiMHQLSLR.
    OrthoDBiEOG7Z69BT.
    TreeFamiTF105195.

    Family and domain databases

    Gene3Di3.40.50.300. 1 hit.
    InterProiIPR003593. AAA+_ATPase.
    IPR011527. ABC1_TM_dom.
    IPR003439. ABC_transporter-like.
    IPR017871. ABC_transporter_CS.
    IPR001140. ABC_transptr_TM_dom.
    IPR027417. P-loop_NTPase.
    [Graphical view]
    PfamiPF00664. ABC_membrane. 1 hit.
    PF00005. ABC_tran. 1 hit.
    [Graphical view]
    SMARTiSM00382. AAA. 1 hit.
    [Graphical view]
    SUPFAMiSSF52540. SSF52540. 1 hit.
    SSF90123. SSF90123. 1 hit.
    PROSITEiPS50929. ABC_TM1F. 1 hit.
    PS00211. ABC_TRANSPORTER_1. 1 hit.
    PS50893. ABC_TRANSPORTER_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q61102-1 [UniParc]FASTAAdd to Basket

    « Hide

    MALLAIHSWR WAAAAVAFEK HKHSAVLTRA LVSMCGSGPR WSSSQRGASG    50
    SARLSQTTES LRNTTQQRWG KDNSRQLLDA TKALQTWPLI EKRTCWHGHA 100
    GGGLHTDPKE GLKDVDTRKI IKAMLSYVWP EDRPDLRARV AISLGFLGGA 150
    KAMNIVVPFM FKYAVDSLNQ MSGNMLNLSD APNTVATMAT AVLIGYGVSR 200
    AGAAFFNEVR NAVFGKVAQN SIRRIAKNVF LHLHNLDLGF HLSRQTGALS 250
    KAIDRGTRGI SFVLSALVFN LLPIVFEMML VSSVLYYKCG AQFALVTLGT 300
    LGAYTAFTVA VTRWRTRFRI EMNKADNDAG NAAIDSLLNY ETVKYFNNEK 350
    YEAQRYDGFL KTYETASLKS TSTLAMLNFG QNAIFSVGLT AIMVLASQGI 400
    VAGALTVGDL VMVNGLLFQL SLPLNFLGTV YRETRQALID MNTLFTLLKV 450
    DTRIKDKVMA PPLQITPQTA TVAFDNVHFE YIEGQKVLNG VSFEVPAGKK 500
    VAIVGGSGSG KSTIVRLLFR FYEPQKGSIY LAGQNLQDVS LESLRRAVGV 550
    VPQDAVLFHN TIYYNLLYGN INASPEEVYA VAKLAGLHDA ILRMPHGYDT 600
    QVGERGLKLS GGEKQRVAIA RAILKNPPVI LYDEATSSLD SITEETILGA 650
    MRDVVKHRTS IFIAHRLSTV VDADEIIVLS QGKVAERGTH YGLLANSSSI 700
    YSEMWHTQSN RVQNQDSLGW DAKKESLSKE EERKKLQEEI VNSVKGCGNC 750
    SC 752
    Length:752
    Mass (Da):82,581
    Last modified:June 28, 2011 - v3
    Checksum:i79B2BC8A7A07555A
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti702 – 7021S → T in BAE30838. (PubMed:16141072)Curated
    Sequence conflicti702 – 7021S → T in BAE31291. (PubMed:16141072)Curated
    Sequence conflicti702 – 7021S → T in BAE31519. (PubMed:16141072)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK151967 mRNA. Translation: BAE30838.1.
    AK152535 mRNA. Translation: BAE31291.1.
    AK152816 mRNA. Translation: BAE31519.1.
    AL663052 Genomic DNA. Translation: CAM17389.1.
    BC151037 mRNA. Translation: AAI51038.1.
    U43892 mRNA. Translation: AAC53152.1.
    CCDSiCCDS53167.1.
    RefSeqiNP_033722.1. NM_009592.1.
    UniGeneiMm.426128.

    Genome annotation databases

    EnsembliENSMUST00000033695; ENSMUSP00000033695; ENSMUSG00000031333.
    GeneIDi11306.
    KEGGimmu:11306.
    UCSCiuc009uaf.2. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK151967 mRNA. Translation: BAE30838.1 .
    AK152535 mRNA. Translation: BAE31291.1 .
    AK152816 mRNA. Translation: BAE31519.1 .
    AL663052 Genomic DNA. Translation: CAM17389.1 .
    BC151037 mRNA. Translation: AAI51038.1 .
    U43892 mRNA. Translation: AAC53152.1 .
    CCDSi CCDS53167.1.
    RefSeqi NP_033722.1. NM_009592.1.
    UniGenei Mm.426128.

    3D structure databases

    ProteinModelPortali Q61102.
    SMRi Q61102. Positions 127-737.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    IntActi Q61102. 3 interactions.
    MINTi MINT-1861698.
    STRINGi 10090.ENSMUSP00000033695.

    PTM databases

    PhosphoSitei Q61102.

    Proteomic databases

    MaxQBi Q61102.
    PaxDbi Q61102.
    PRIDEi Q61102.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000033695 ; ENSMUSP00000033695 ; ENSMUSG00000031333 .
    GeneIDi 11306.
    KEGGi mmu:11306.
    UCSCi uc009uaf.2. mouse.

    Organism-specific databases

    CTDi 22.
    MGIi MGI:109533. Abcb7.

    Phylogenomic databases

    eggNOGi COG5265.
    GeneTreei ENSGT00440000033373.
    HOVERGENi HBG080194.
    InParanoidi A2AC46.
    KOi K05662.
    OMAi MHQLSLR.
    OrthoDBi EOG7Z69BT.
    TreeFami TF105195.

    Enzyme and pathway databases

    Reactomei REACT_196637. Cytosolic iron-sulfur cluster assembly.
    REACT_197885. Mitochondrial ABC transporters.

    Miscellaneous databases

    ChiTaRSi ABCB7. mouse.
    NextBioi 278598.
    PROi Q61102.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q61102.
    Genevestigatori Q61102.

    Family and domain databases

    Gene3Di 3.40.50.300. 1 hit.
    InterProi IPR003593. AAA+_ATPase.
    IPR011527. ABC1_TM_dom.
    IPR003439. ABC_transporter-like.
    IPR017871. ABC_transporter_CS.
    IPR001140. ABC_transptr_TM_dom.
    IPR027417. P-loop_NTPase.
    [Graphical view ]
    Pfami PF00664. ABC_membrane. 1 hit.
    PF00005. ABC_tran. 1 hit.
    [Graphical view ]
    SMARTi SM00382. AAA. 1 hit.
    [Graphical view ]
    SUPFAMi SSF52540. SSF52540. 1 hit.
    SSF90123. SSF90123. 1 hit.
    PROSITEi PS50929. ABC_TM1F. 1 hit.
    PS00211. ABC_TRANSPORTER_1. 1 hit.
    PS50893. ABC_TRANSPORTER_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6J.
      Tissue: Bone marrow.
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: C57BL/6J.
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Brain.
    4. "Isolation and chromosomal mapping of a novel ATP-binding cassette transporter conserved in mouse and human."
      Savary S., Allikmets R., Denizot F., Luciani M.-F., Mattei M.-G., Dean M., Chimini G.
      Genomics 41:275-278(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 59-752.
      Strain: DBA/2.
    5. "Label-free quantitative proteomics of the lysine acetylome in mitochondria identifies substrates of SIRT3 in metabolic pathways."
      Rardin M.J., Newman J.C., Held J.M., Cusack M.P., Sorensen D.J., Li B., Schilling B., Mooney S.D., Kahn C.R., Verdin E., Gibson B.W.
      Proc. Natl. Acad. Sci. U.S.A. 110:6601-6606(2013) [PubMed] [Europe PMC] [Abstract]
      Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-216; LYS-251 AND LYS-350, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Liver.

    Entry informationi

    Entry nameiABCB7_MOUSE
    AccessioniPrimary (citable) accession number: Q61102
    Secondary accession number(s): A2AC46, Q3U7S8
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 15, 1998
    Last sequence update: June 28, 2011
    Last modified: October 1, 2014
    This is version 121 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3