Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

Q61102 (ABCB7_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 119. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
ATP-binding cassette sub-family B member 7, mitochondrial
Alternative name(s):
ATP-binding cassette transporter 7
Short name=ABC transporter 7 protein
Gene names
Name:Abcb7
Synonyms:Abc7
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length752 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Could be involved in the transport of heme from the mitochondria to the cytosol. Plays a central role in the maturation of cytosolic iron-sulfur (Fe/S) cluster-containing proteins By similarity.

Subunit structure

Homodimer or heterodimer Potential.

Subcellular location

Mitochondrion inner membrane; Multi-pass membrane protein Potential.

Sequence similarities

Belongs to the ABC transporter superfamily. ABCB family. Heavy Metal importer (TC 3.A.1.210) subfamily. [View classification]

Contains 1 ABC transmembrane type-1 domain.

Contains 1 ABC transporter domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 752752ATP-binding cassette sub-family B member 7, mitochondrial
PRO_0000093295

Regions

Transmembrane141 – 16121Helical; Potential
Transmembrane186 – 20621Helical; Potential
Transmembrane260 – 28021Helical; Potential
Transmembrane291 – 31121Helical; Potential
Transmembrane383 – 40321Helical; Potential
Transmembrane410 – 43021Helical; Potential
Domain140 – 436297ABC transmembrane type-1
Domain472 – 706235ABC transporter
Nucleotide binding505 – 51612ATP By similarity
Compositional bias12 – 176Poly-Ala

Sites

Binding site4811ATP By similarity

Amino acid modifications

Modified residue2161N6-acetyllysine Ref.5
Modified residue2511N6-acetyllysine Ref.5
Modified residue3361Phosphoserine By similarity
Modified residue3401Phosphotyrosine By similarity
Modified residue3421Phosphothreonine By similarity
Modified residue3501N6-acetyllysine Ref.5

Experimental info

Sequence conflict7021S → T in BAE30838. Ref.1
Sequence conflict7021S → T in BAE31291. Ref.1
Sequence conflict7021S → T in BAE31519. Ref.1

Sequences

Sequence LengthMass (Da)Tools
Q61102 [UniParc].

Last modified June 28, 2011. Version 3.
Checksum: 79B2BC8A7A07555A

FASTA75282,581
        10         20         30         40         50         60 
MALLAIHSWR WAAAAVAFEK HKHSAVLTRA LVSMCGSGPR WSSSQRGASG SARLSQTTES 

        70         80         90        100        110        120 
LRNTTQQRWG KDNSRQLLDA TKALQTWPLI EKRTCWHGHA GGGLHTDPKE GLKDVDTRKI 

       130        140        150        160        170        180 
IKAMLSYVWP EDRPDLRARV AISLGFLGGA KAMNIVVPFM FKYAVDSLNQ MSGNMLNLSD 

       190        200        210        220        230        240 
APNTVATMAT AVLIGYGVSR AGAAFFNEVR NAVFGKVAQN SIRRIAKNVF LHLHNLDLGF 

       250        260        270        280        290        300 
HLSRQTGALS KAIDRGTRGI SFVLSALVFN LLPIVFEMML VSSVLYYKCG AQFALVTLGT 

       310        320        330        340        350        360 
LGAYTAFTVA VTRWRTRFRI EMNKADNDAG NAAIDSLLNY ETVKYFNNEK YEAQRYDGFL 

       370        380        390        400        410        420 
KTYETASLKS TSTLAMLNFG QNAIFSVGLT AIMVLASQGI VAGALTVGDL VMVNGLLFQL 

       430        440        450        460        470        480 
SLPLNFLGTV YRETRQALID MNTLFTLLKV DTRIKDKVMA PPLQITPQTA TVAFDNVHFE 

       490        500        510        520        530        540 
YIEGQKVLNG VSFEVPAGKK VAIVGGSGSG KSTIVRLLFR FYEPQKGSIY LAGQNLQDVS 

       550        560        570        580        590        600 
LESLRRAVGV VPQDAVLFHN TIYYNLLYGN INASPEEVYA VAKLAGLHDA ILRMPHGYDT 

       610        620        630        640        650        660 
QVGERGLKLS GGEKQRVAIA RAILKNPPVI LYDEATSSLD SITEETILGA MRDVVKHRTS 

       670        680        690        700        710        720 
IFIAHRLSTV VDADEIIVLS QGKVAERGTH YGLLANSSSI YSEMWHTQSN RVQNQDSLGW 

       730        740        750 
DAKKESLSKE EERKKLQEEI VNSVKGCGNC SC 

« Hide

References

« Hide 'large scale' references
[1]"The transcriptional landscape of the mammalian genome."
Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. expand/collapse author list , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: C57BL/6J.
Tissue: Bone marrow.
[2]"Lineage-specific biology revealed by a finished genome assembly of the mouse."
Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X., Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y., Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S. expand/collapse author list , Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R., Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K., Eichler E.E., Ponting C.P.
PLoS Biol. 7:E1000112-E1000112(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: C57BL/6J.
[3]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Brain.
[4]"Isolation and chromosomal mapping of a novel ATP-binding cassette transporter conserved in mouse and human."
Savary S., Allikmets R., Denizot F., Luciani M.-F., Mattei M.-G., Dean M., Chimini G.
Genomics 41:275-278(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 59-752.
Strain: DBA/2.
[5]"Label-free quantitative proteomics of the lysine acetylome in mitochondria identifies substrates of SIRT3 in metabolic pathways."
Rardin M.J., Newman J.C., Held J.M., Cusack M.P., Sorensen D.J., Li B., Schilling B., Mooney S.D., Kahn C.R., Verdin E., Gibson B.W.
Proc. Natl. Acad. Sci. U.S.A. 110:6601-6606(2013) [PubMed] [Europe PMC] [Abstract]
Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-216; LYS-251 AND LYS-350, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
Tissue: Liver.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AK151967 mRNA. Translation: BAE30838.1.
AK152535 mRNA. Translation: BAE31291.1.
AK152816 mRNA. Translation: BAE31519.1.
AL663052 Genomic DNA. Translation: CAM17389.1.
BC151037 mRNA. Translation: AAI51038.1.
U43892 mRNA. Translation: AAC53152.1.
CCDSCCDS53167.1.
RefSeqNP_033722.1. NM_009592.1.
UniGeneMm.426128.

3D structure databases

ProteinModelPortalQ61102.
SMRQ61102. Positions 127-737.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

IntActQ61102. 3 interactions.
MINTMINT-1861698.
STRING10090.ENSMUSP00000033695.

PTM databases

PhosphoSiteQ61102.

Proteomic databases

MaxQBQ61102.
PaxDbQ61102.
PRIDEQ61102.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000033695; ENSMUSP00000033695; ENSMUSG00000031333.
GeneID11306.
KEGGmmu:11306.
UCSCuc009uaf.2. mouse.

Organism-specific databases

CTD22.
MGIMGI:109533. Abcb7.

Phylogenomic databases

eggNOGCOG5265.
GeneTreeENSGT00440000033373.
HOVERGENHBG080194.
InParanoidA2AC46.
KOK05662.
OMAMHQLSLR.
OrthoDBEOG7Z69BT.
TreeFamTF105195.

Gene expression databases

BgeeQ61102.
GenevestigatorQ61102.

Family and domain databases

Gene3D3.40.50.300. 1 hit.
InterProIPR003593. AAA+_ATPase.
IPR011527. ABC1_TM_dom.
IPR003439. ABC_transporter-like.
IPR017871. ABC_transporter_CS.
IPR001140. ABC_transptr_TM_dom.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamPF00664. ABC_membrane. 1 hit.
PF00005. ABC_tran. 1 hit.
[Graphical view]
SMARTSM00382. AAA. 1 hit.
[Graphical view]
SUPFAMSSF52540. SSF52540. 1 hit.
SSF90123. SSF90123. 1 hit.
PROSITEPS50929. ABC_TM1F. 1 hit.
PS00211. ABC_TRANSPORTER_1. 1 hit.
PS50893. ABC_TRANSPORTER_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSABCB7. mouse.
NextBio278598.
PROQ61102.
SOURCESearch...

Entry information

Entry nameABCB7_MOUSE
AccessionPrimary (citable) accession number: Q61102
Secondary accession number(s): A2AC46, Q3U7S8
Entry history
Integrated into UniProtKB/Swiss-Prot: December 15, 1998
Last sequence update: June 28, 2011
Last modified: July 9, 2014
This is version 119 of the entry and version 3 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot