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Q61102

- ABCB7_MOUSE

UniProt

Q61102 - ABCB7_MOUSE

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Protein
ATP-binding cassette sub-family B member 7, mitochondrial
Gene
Abcb7, Abc7
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at protein leveli

Functioni

Could be involved in the transport of heme from the mitochondria to the cytosol. Plays a central role in the maturation of cytosolic iron-sulfur (Fe/S) cluster-containing proteins By similarity.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei481 – 4811ATP By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi505 – 51612ATP By similarity
Add
BLAST

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. ATPase activity, coupled to transmembrane movement of substances Source: RefGenome

GO - Biological processi

  1. cellular iron ion homeostasis Source: MGI
  2. transmembrane transport Source: RefGenome
Complete GO annotation...

Keywords - Biological processi

Transport

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiREACT_196637. Cytosolic iron-sulfur cluster assembly.
REACT_197885. Mitochondrial ABC transporters.

Names & Taxonomyi

Protein namesi
Recommended name:
ATP-binding cassette sub-family B member 7, mitochondrial
Alternative name(s):
ATP-binding cassette transporter 7
Short name:
ABC transporter 7 protein
Gene namesi
Name:Abcb7
Synonyms:Abc7
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome X

Organism-specific databases

MGIiMGI:109533. Abcb7.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei141 – 16121Helical; Reviewed prediction
Add
BLAST
Transmembranei186 – 20621Helical; Reviewed prediction
Add
BLAST
Transmembranei260 – 28021Helical; Reviewed prediction
Add
BLAST
Transmembranei291 – 31121Helical; Reviewed prediction
Add
BLAST
Transmembranei383 – 40321Helical; Reviewed prediction
Add
BLAST
Transmembranei410 – 43021Helical; Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: RefGenome
  2. mitochondrial inner membrane Source: MGI
  3. mitochondrion Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 752752ATP-binding cassette sub-family B member 7, mitochondrial
PRO_0000093295Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei216 – 2161N6-acetyllysine1 Publication
Modified residuei251 – 2511N6-acetyllysine1 Publication
Modified residuei336 – 3361Phosphoserine By similarity
Modified residuei340 – 3401Phosphotyrosine By similarity
Modified residuei342 – 3421Phosphothreonine By similarity
Modified residuei350 – 3501N6-acetyllysine1 Publication

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

MaxQBiQ61102.
PaxDbiQ61102.
PRIDEiQ61102.

PTM databases

PhosphoSiteiQ61102.

Expressioni

Gene expression databases

BgeeiQ61102.
GenevestigatoriQ61102.

Interactioni

Subunit structurei

Homodimer or heterodimer Reviewed prediction.

Protein-protein interaction databases

IntActiQ61102. 3 interactions.
MINTiMINT-1861698.
STRINGi10090.ENSMUSP00000033695.

Structurei

3D structure databases

ProteinModelPortaliQ61102.
SMRiQ61102. Positions 127-737.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini140 – 436297ABC transmembrane type-1
Add
BLAST
Domaini472 – 706235ABC transporter
Add
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi12 – 176Poly-Ala

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG5265.
GeneTreeiENSGT00440000033373.
HOVERGENiHBG080194.
InParanoidiA2AC46.
KOiK05662.
OMAiMHQLSLR.
OrthoDBiEOG7Z69BT.
TreeFamiTF105195.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR003593. AAA+_ATPase.
IPR011527. ABC1_TM_dom.
IPR003439. ABC_transporter-like.
IPR017871. ABC_transporter_CS.
IPR001140. ABC_transptr_TM_dom.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF00664. ABC_membrane. 1 hit.
PF00005. ABC_tran. 1 hit.
[Graphical view]
SMARTiSM00382. AAA. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
SSF90123. SSF90123. 1 hit.
PROSITEiPS50929. ABC_TM1F. 1 hit.
PS00211. ABC_TRANSPORTER_1. 1 hit.
PS50893. ABC_TRANSPORTER_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q61102-1 [UniParc]FASTAAdd to Basket

« Hide

MALLAIHSWR WAAAAVAFEK HKHSAVLTRA LVSMCGSGPR WSSSQRGASG    50
SARLSQTTES LRNTTQQRWG KDNSRQLLDA TKALQTWPLI EKRTCWHGHA 100
GGGLHTDPKE GLKDVDTRKI IKAMLSYVWP EDRPDLRARV AISLGFLGGA 150
KAMNIVVPFM FKYAVDSLNQ MSGNMLNLSD APNTVATMAT AVLIGYGVSR 200
AGAAFFNEVR NAVFGKVAQN SIRRIAKNVF LHLHNLDLGF HLSRQTGALS 250
KAIDRGTRGI SFVLSALVFN LLPIVFEMML VSSVLYYKCG AQFALVTLGT 300
LGAYTAFTVA VTRWRTRFRI EMNKADNDAG NAAIDSLLNY ETVKYFNNEK 350
YEAQRYDGFL KTYETASLKS TSTLAMLNFG QNAIFSVGLT AIMVLASQGI 400
VAGALTVGDL VMVNGLLFQL SLPLNFLGTV YRETRQALID MNTLFTLLKV 450
DTRIKDKVMA PPLQITPQTA TVAFDNVHFE YIEGQKVLNG VSFEVPAGKK 500
VAIVGGSGSG KSTIVRLLFR FYEPQKGSIY LAGQNLQDVS LESLRRAVGV 550
VPQDAVLFHN TIYYNLLYGN INASPEEVYA VAKLAGLHDA ILRMPHGYDT 600
QVGERGLKLS GGEKQRVAIA RAILKNPPVI LYDEATSSLD SITEETILGA 650
MRDVVKHRTS IFIAHRLSTV VDADEIIVLS QGKVAERGTH YGLLANSSSI 700
YSEMWHTQSN RVQNQDSLGW DAKKESLSKE EERKKLQEEI VNSVKGCGNC 750
SC 752
Length:752
Mass (Da):82,581
Last modified:June 28, 2011 - v3
Checksum:i79B2BC8A7A07555A
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti702 – 7021S → T in BAE30838. 1 Publication
Sequence conflicti702 – 7021S → T in BAE31291. 1 Publication
Sequence conflicti702 – 7021S → T in BAE31519. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK151967 mRNA. Translation: BAE30838.1.
AK152535 mRNA. Translation: BAE31291.1.
AK152816 mRNA. Translation: BAE31519.1.
AL663052 Genomic DNA. Translation: CAM17389.1.
BC151037 mRNA. Translation: AAI51038.1.
U43892 mRNA. Translation: AAC53152.1.
CCDSiCCDS53167.1.
RefSeqiNP_033722.1. NM_009592.1.
UniGeneiMm.426128.

Genome annotation databases

EnsembliENSMUST00000033695; ENSMUSP00000033695; ENSMUSG00000031333.
GeneIDi11306.
KEGGimmu:11306.
UCSCiuc009uaf.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK151967 mRNA. Translation: BAE30838.1 .
AK152535 mRNA. Translation: BAE31291.1 .
AK152816 mRNA. Translation: BAE31519.1 .
AL663052 Genomic DNA. Translation: CAM17389.1 .
BC151037 mRNA. Translation: AAI51038.1 .
U43892 mRNA. Translation: AAC53152.1 .
CCDSi CCDS53167.1.
RefSeqi NP_033722.1. NM_009592.1.
UniGenei Mm.426128.

3D structure databases

ProteinModelPortali Q61102.
SMRi Q61102. Positions 127-737.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

IntActi Q61102. 3 interactions.
MINTi MINT-1861698.
STRINGi 10090.ENSMUSP00000033695.

PTM databases

PhosphoSitei Q61102.

Proteomic databases

MaxQBi Q61102.
PaxDbi Q61102.
PRIDEi Q61102.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000033695 ; ENSMUSP00000033695 ; ENSMUSG00000031333 .
GeneIDi 11306.
KEGGi mmu:11306.
UCSCi uc009uaf.2. mouse.

Organism-specific databases

CTDi 22.
MGIi MGI:109533. Abcb7.

Phylogenomic databases

eggNOGi COG5265.
GeneTreei ENSGT00440000033373.
HOVERGENi HBG080194.
InParanoidi A2AC46.
KOi K05662.
OMAi MHQLSLR.
OrthoDBi EOG7Z69BT.
TreeFami TF105195.

Enzyme and pathway databases

Reactomei REACT_196637. Cytosolic iron-sulfur cluster assembly.
REACT_197885. Mitochondrial ABC transporters.

Miscellaneous databases

ChiTaRSi ABCB7. mouse.
NextBioi 278598.
PROi Q61102.
SOURCEi Search...

Gene expression databases

Bgeei Q61102.
Genevestigatori Q61102.

Family and domain databases

Gene3Di 3.40.50.300. 1 hit.
InterProi IPR003593. AAA+_ATPase.
IPR011527. ABC1_TM_dom.
IPR003439. ABC_transporter-like.
IPR017871. ABC_transporter_CS.
IPR001140. ABC_transptr_TM_dom.
IPR027417. P-loop_NTPase.
[Graphical view ]
Pfami PF00664. ABC_membrane. 1 hit.
PF00005. ABC_tran. 1 hit.
[Graphical view ]
SMARTi SM00382. AAA. 1 hit.
[Graphical view ]
SUPFAMi SSF52540. SSF52540. 1 hit.
SSF90123. SSF90123. 1 hit.
PROSITEi PS50929. ABC_TM1F. 1 hit.
PS00211. ABC_TRANSPORTER_1. 1 hit.
PS50893. ABC_TRANSPORTER_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Bone marrow.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain.
  4. "Isolation and chromosomal mapping of a novel ATP-binding cassette transporter conserved in mouse and human."
    Savary S., Allikmets R., Denizot F., Luciani M.-F., Mattei M.-G., Dean M., Chimini G.
    Genomics 41:275-278(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 59-752.
    Strain: DBA/2.
  5. "Label-free quantitative proteomics of the lysine acetylome in mitochondria identifies substrates of SIRT3 in metabolic pathways."
    Rardin M.J., Newman J.C., Held J.M., Cusack M.P., Sorensen D.J., Li B., Schilling B., Mooney S.D., Kahn C.R., Verdin E., Gibson B.W.
    Proc. Natl. Acad. Sci. U.S.A. 110:6601-6606(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-216; LYS-251 AND LYS-350, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Liver.

Entry informationi

Entry nameiABCB7_MOUSE
AccessioniPrimary (citable) accession number: Q61102
Secondary accession number(s): A2AC46, Q3U7S8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 15, 1998
Last sequence update: June 28, 2011
Last modified: September 3, 2014
This is version 120 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi