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Q61098

- IL18R_MOUSE

UniProt

Q61098 - IL18R_MOUSE

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Protein
Interleukin-18 receptor 1
Gene
Il18r1
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at transcript leveli

Functioni

Receptor for interleukin 18 (IL-18). Binding to the agonist leads to the activation of NF-kappa-B.

GO - Molecular functioni

  1. interleukin-18 receptor activity Source: MGI

GO - Biological processi

  1. T-helper 1 cell differentiation Source: MGI
  2. interleukin-18-mediated signaling pathway Source: MGI
  3. natural killer cell activation Source: MGI
  4. positive regulation of NF-kappaB import into nucleus Source: MGI
  5. positive regulation of interferon-gamma production Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

Receptor

Names & Taxonomyi

Protein namesi
Recommended name:
Interleukin-18 receptor 1
Short name:
IL-18R-1
Short name:
IL-18R1
Alternative name(s):
CD218 antigen-like family member A
IL1 receptor-related protein
Short name:
IL-1Rrp
Short name:
IL1R-rp
CD_antigen: CD218a
Gene namesi
Name:Il18r1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 1

Organism-specific databases

MGIiMGI:105383. Il18r1.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini20 – 326307Extracellular Reviewed prediction
Add
BLAST
Transmembranei327 – 34721Helical; Reviewed prediction
Add
BLAST
Topological domaini348 – 537190Cytoplasmic Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1919 Reviewed prediction
Add
BLAST
Chaini20 – 537518Interleukin-18 receptor 1
PRO_0000015449Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi50 – 501N-linked (GlcNAc...) Reviewed prediction
Glycosylationi71 – 711N-linked (GlcNAc...) Reviewed prediction
Glycosylationi107 – 1071N-linked (GlcNAc...) Reviewed prediction
Glycosylationi111 – 1111N-linked (GlcNAc...) Reviewed prediction
Glycosylationi134 – 1341N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi141 ↔ 182 By similarity
Glycosylationi189 – 1891N-linked (GlcNAc...) Reviewed prediction
Glycosylationi194 – 1941N-linked (GlcNAc...) Reviewed prediction
Glycosylationi200 – 2001N-linked (GlcNAc...) Reviewed prediction
Glycosylationi233 – 2331N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi234 ↔ 296 By similarity
Glycosylationi295 – 2951N-linked (GlcNAc...) Reviewed prediction

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ61098.
PRIDEiQ61098.

PTM databases

PhosphoSiteiQ61098.

Expressioni

Gene expression databases

ArrayExpressiQ61098.
BgeeiQ61098.
CleanExiMM_IL18R1.
GenevestigatoriQ61098.

Interactioni

Subunit structurei

Does not bind IL1A/interleukin-1 alpha or IL1B/interleukin-1 beta.

Structurei

3D structure databases

ProteinModelPortaliQ61098.
SMRiQ61098. Positions 24-305, 370-517.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini33 – 10270Ig-like C2-type 1
Add
BLAST
Domaini134 – 18956Ig-like C2-type 2
Add
BLAST
Domaini212 – 312101Ig-like C2-type 3
Add
BLAST
Domaini370 – 519150TIR
Add
BLAST

Sequence similaritiesi

Contains 1 TIR domain.

Keywords - Domaini

Immunoglobulin domain, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG121812.
GeneTreeiENSGT00680000099639.
HOGENOMiHOG000113032.
HOVERGENiHBG052098.
InParanoidiQ61098.
KOiK05173.
OMAiRGMIIAV.
OrthoDBiEOG7CVPXJ.
PhylomeDBiQ61098.
TreeFamiTF325519.

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
3.40.50.10140. 1 hit.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
IPR015621. IL-1_rcpt_fam.
IPR013151. Immunoglobulin.
IPR000157. TIR_dom.
[Graphical view]
PANTHERiPTHR11890. PTHR11890. 1 hit.
PfamiPF00047. ig. 1 hit.
PF01582. TIR. 1 hit.
[Graphical view]
SMARTiSM00409. IG. 2 hits.
SM00255. TIR. 1 hit.
[Graphical view]
SUPFAMiSSF52200. SSF52200. 1 hit.
PROSITEiPS50835. IG_LIKE. 1 hit.
PS50104. TIR. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q61098-1 [UniParc]FASTAAdd to Basket

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MHHEELILTL CILIVKSASK SCIHRSQIHV VEGEPFYLKP CGISAPVHRN    50
ETATMRWFKG SASHEYRELN NRSSPRVTFH DHTLEFWPVE MEDEGTYISQ 100
VGNDRRNWTL NVTKRNKHSC FSDKLVTSRD VEVNKSLHIT CKNPNYEELI 150
QDTWLYKNCK EISKTPRILK DAEFGDEGYY SCVFSVHHNG TRYNITKTVN 200
ITVIEGRSKV TPAILGPKCE KVGVELGKDV ELNCSASLNK DDLFYWSIRK 250
EDSSDPNVQE DRKETTTWIS EGKLHASKIL RFQKITENYL NVLYNCTVAN 300
EEAIDTKSFV LVRKEIPDIP GHVFTGGVTV LVLASVAAVC IVILCVIYKV 350
DLVLFYRRIA ERDETLTDGK TYDAFVSYLK ECHPENKEEY TFAVETLPRV 400
LEKQFGYKLC IFERDVVPGG AVVEEIHSLI EKSRRLIIVL SQSYLTNGAR 450
RELESGLHEA LVERKIKIIL IEFTPASNIT FLPPSLKLLK SYRVLKWRAD 500
SPSMNSRFWK NLVYLMPAKA VKPWREESEA RSVLSAP 537
Length:537
Mass (Da):61,601
Last modified:November 1, 1996 - v1
Checksum:iB119FEA403355458
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti317 – 3171Missing.

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U43673 mRNA. Translation: AAC52437.1.
CCDSiCCDS35549.1.
RefSeqiNP_032391.1. NM_008365.2.
XP_006495790.1. XM_006495727.1.
XP_006495791.1. XM_006495728.1.
XP_006495792.1. XM_006495729.1.
XP_006495793.1. XM_006495730.1.
XP_006495794.1. XM_006495731.1.
XP_006495795.1. XM_006495732.1.
XP_006495796.1. XM_006495733.1.
XP_006495797.1. XM_006495734.1.
UniGeneiMm.253664.

Genome annotation databases

EnsembliENSMUST00000087983; ENSMUSP00000085298; ENSMUSG00000026070.
ENSMUST00000108044; ENSMUSP00000103679; ENSMUSG00000026070.
GeneIDi16182.
KEGGimmu:16182.
UCSCiuc011wjz.1. mouse.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U43673 mRNA. Translation: AAC52437.1 .
CCDSi CCDS35549.1.
RefSeqi NP_032391.1. NM_008365.2.
XP_006495790.1. XM_006495727.1.
XP_006495791.1. XM_006495728.1.
XP_006495792.1. XM_006495729.1.
XP_006495793.1. XM_006495730.1.
XP_006495794.1. XM_006495731.1.
XP_006495795.1. XM_006495732.1.
XP_006495796.1. XM_006495733.1.
XP_006495797.1. XM_006495734.1.
UniGenei Mm.253664.

3D structure databases

ProteinModelPortali Q61098.
SMRi Q61098. Positions 24-305, 370-517.
ModBasei Search...
MobiDBi Search...

PTM databases

PhosphoSitei Q61098.

Proteomic databases

PaxDbi Q61098.
PRIDEi Q61098.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000087983 ; ENSMUSP00000085298 ; ENSMUSG00000026070 .
ENSMUST00000108044 ; ENSMUSP00000103679 ; ENSMUSG00000026070 .
GeneIDi 16182.
KEGGi mmu:16182.
UCSCi uc011wjz.1. mouse.

Organism-specific databases

CTDi 8809.
MGIi MGI:105383. Il18r1.

Phylogenomic databases

eggNOGi NOG121812.
GeneTreei ENSGT00680000099639.
HOGENOMi HOG000113032.
HOVERGENi HBG052098.
InParanoidi Q61098.
KOi K05173.
OMAi RGMIIAV.
OrthoDBi EOG7CVPXJ.
PhylomeDBi Q61098.
TreeFami TF325519.

Miscellaneous databases

NextBioi 289065.
PROi Q61098.
SOURCEi Search...

Gene expression databases

ArrayExpressi Q61098.
Bgeei Q61098.
CleanExi MM_IL18R1.
Genevestigatori Q61098.

Family and domain databases

Gene3Di 2.60.40.10. 1 hit.
3.40.50.10140. 1 hit.
InterProi IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
IPR015621. IL-1_rcpt_fam.
IPR013151. Immunoglobulin.
IPR000157. TIR_dom.
[Graphical view ]
PANTHERi PTHR11890. PTHR11890. 1 hit.
Pfami PF00047. ig. 1 hit.
PF01582. TIR. 1 hit.
[Graphical view ]
SMARTi SM00409. IG. 2 hits.
SM00255. TIR. 1 hit.
[Graphical view ]
SUPFAMi SSF52200. SSF52200. 1 hit.
PROSITEi PS50835. IG_LIKE. 1 hit.
PS50104. TIR. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "IL-1Rrp is a novel receptor-like molecule similar to the type I interleukin-1 receptor and its homologues T1/ST2 and IL-1R AcP."
    Parnet P., Garka K.E., Bonnert T.P., Dower S.K., Sims J.E.
    J. Biol. Chem. 271:3967-3970(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANT ALA-317 DEL.

Entry informationi

Entry nameiIL18R_MOUSE
AccessioniPrimary (citable) accession number: Q61098
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 6, 2002
Last sequence update: November 1, 1996
Last modified: July 9, 2014
This is version 121 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi