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Q61098 (IL18R_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified May 1, 2013. Version 111. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Interleukin-18 receptor 1
Short name=IL-18R-1
Short name=IL-18R1
Alternative name(s):
CD218 antigen-like family member A
IL1 receptor-related protein
Short name=IL-1Rrp
Short name=IL1R-rp
CD_antigen=CD218a
Gene names
Name:Il18r1
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length537 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Receptor for interleukin 18 (IL-18). Binding to the agonist leads to the activation of NF-kappa-B.

Subunit structure

Does not bind IL1A/interleukin-1 alpha or IL1B/interleukin-1 beta.

Subcellular location

Membrane; Single-pass type I membrane protein.

Sequence similarities

Belongs to the interleukin-1 receptor family.

Contains 3 Ig-like C2-type (immunoglobulin-like) domains.

Contains 1 TIR domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 1919 Potential
Chain20 – 537518Interleukin-18 receptor 1
PRO_0000015449

Regions

Topological domain20 – 326307Extracellular Potential
Transmembrane327 – 34721Helical; Potential
Topological domain348 – 537190Cytoplasmic Potential
Domain33 – 10270Ig-like C2-type 1
Domain134 – 18956Ig-like C2-type 2
Domain212 – 312101Ig-like C2-type 3
Domain370 – 519150TIR

Amino acid modifications

Glycosylation501N-linked (GlcNAc...) Potential
Glycosylation711N-linked (GlcNAc...) Potential
Glycosylation1071N-linked (GlcNAc...) Potential
Glycosylation1111N-linked (GlcNAc...) Potential
Glycosylation1341N-linked (GlcNAc...) Potential
Glycosylation1891N-linked (GlcNAc...) Potential
Glycosylation1941N-linked (GlcNAc...) Potential
Glycosylation2001N-linked (GlcNAc...) Potential
Glycosylation2331N-linked (GlcNAc...) Potential
Glycosylation2951N-linked (GlcNAc...) Potential
Disulfide bond141 ↔ 182 By similarity
Disulfide bond234 ↔ 296 By similarity

Natural variations

Natural variant3171Missing.

Sequences

Sequence LengthMass (Da)Tools
Q61098 [UniParc].

Last modified November 1, 1996. Version 1.
Checksum: B119FEA403355458

FASTA53761,601
        10         20         30         40         50         60 
MHHEELILTL CILIVKSASK SCIHRSQIHV VEGEPFYLKP CGISAPVHRN ETATMRWFKG 

        70         80         90        100        110        120 
SASHEYRELN NRSSPRVTFH DHTLEFWPVE MEDEGTYISQ VGNDRRNWTL NVTKRNKHSC 

       130        140        150        160        170        180 
FSDKLVTSRD VEVNKSLHIT CKNPNYEELI QDTWLYKNCK EISKTPRILK DAEFGDEGYY 

       190        200        210        220        230        240 
SCVFSVHHNG TRYNITKTVN ITVIEGRSKV TPAILGPKCE KVGVELGKDV ELNCSASLNK 

       250        260        270        280        290        300 
DDLFYWSIRK EDSSDPNVQE DRKETTTWIS EGKLHASKIL RFQKITENYL NVLYNCTVAN 

       310        320        330        340        350        360 
EEAIDTKSFV LVRKEIPDIP GHVFTGGVTV LVLASVAAVC IVILCVIYKV DLVLFYRRIA 

       370        380        390        400        410        420 
ERDETLTDGK TYDAFVSYLK ECHPENKEEY TFAVETLPRV LEKQFGYKLC IFERDVVPGG 

       430        440        450        460        470        480 
AVVEEIHSLI EKSRRLIIVL SQSYLTNGAR RELESGLHEA LVERKIKIIL IEFTPASNIT 

       490        500        510        520        530 
FLPPSLKLLK SYRVLKWRAD SPSMNSRFWK NLVYLMPAKA VKPWREESEA RSVLSAP

« Hide

References

[1]"IL-1Rrp is a novel receptor-like molecule similar to the type I interleukin-1 receptor and its homologues T1/ST2 and IL-1R AcP."
Parnet P., Garka K.E., Bonnert T.P., Dower S.K., Sims J.E.
J. Biol. Chem. 271:3967-3970(1996) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANT ALA-317 DEL.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		U43673 mRNA. Translation: AAC52437.1.
IPIIPI00117123.
RefSeqNP_032391.1. NM_008365.2.
UniGeneMm.253664.

3D structure databases

ProteinModelPortalQ61098.
SMRQ61098. Positions 38-305, 370-517.
ModBaseSearch...

PTM databases

PhosphoSiteQ61098.

Proteomic databases

PaxDbQ61098.
PRIDEQ61098.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000087983; ENSMUSP00000085298; ENSMUSG00000026070.
ENSMUST00000108044; ENSMUSP00000103679; ENSMUSG00000026070.
GeneID16182.
KEGGmmu:16182.
UCSCuc011wjz.1. mouse.

Organism-specific databases

CTD8809.
MGIMGI:105383. Il18r1.

Phylogenomic databases

eggNOGNOG121812.
GeneTreeENSGT00680000099639.
HOGENOMHOG000113032.
HOVERGENHBG052098.
InParanoidQ61098.
KOK05173.
OMAGSASHEY.

Gene expression databases

ArrayExpressQ61098.
BgeeQ61098.
CleanExMM_IL18R1.
GenevestigatorQ61098.
GermOnlineENSMUSG00000026070. Mus musculus.

Family and domain databases

Gene3D2.60.40.10. 1 hit.
InterProIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
IPR015621. IL1-receptor_fam.
IPR013151. Immunoglobulin.
IPR000157. TIR_dom.
[Graphical view]
PANTHERPTHR11890. PTHR11890. 1 hit.
PfamPF00047. ig. 1 hit.
PF01582. TIR. 1 hit.
[Graphical view]
SMARTSM00409. IG. 2 hits.
SM00255. TIR. 1 hit.
[Graphical view]
SUPFAMSSF52200. TIR. 1 hit.
PROSITEPS50835. IG_LIKE. 1 hit.
PS50104. TIR. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio289065.
SOURCESearch...

Entry information

Entry nameIL18R_MOUSE
AccessionPrimary (citable) accession number: Q61098
Entry history
Integrated into UniProtKB/Swiss-Prot: December 6, 2002
Last sequence update: November 1, 1996
Last modified: May 1, 2013
This is version 111 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

SIMILARITY comments

Index of protein domains and families

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