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Protein

Interleukin-18 receptor 1

Gene

Il18r1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Within the IL18 receptor complex, responsible for the binding of the proinflammatory cytokine IL18, but not IL1A nor IL1B (Probable). Contributes to IL18-induced cytokine production, either independently of SLC12A3, or as a complex with SLC12A3 (PubMed:26099046).1 Publication1 Publication

GO - Molecular functioni

  • interleukin-18 receptor activity Source: MGI

GO - Biological processi

  • interleukin-18-mediated signaling pathway Source: MGI
  • natural killer cell activation Source: MGI
  • positive regulation of interferon-gamma production Source: MGI
  • positive regulation of NIK/NF-kappaB signaling Source: MGI
  • T-helper 1 cell differentiation Source: MGI

Keywordsi

Molecular functionReceptor

Enzyme and pathway databases

ReactomeiR-MMU-9012546 Interleukin-18 signaling

Names & Taxonomyi

Protein namesi
Recommended name:
Interleukin-18 receptor 1
Short name:
IL-18R-1
Short name:
IL-18R1
Alternative name(s):
CD218 antigen-like family member A
IL1 receptor-related protein
Short name:
IL-1Rrp
Short name:
IL1R-rp
CD_antigen: CD218a
Gene namesi
Name:Il18r1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 1

Organism-specific databases

MGIiMGI:105383 Il18r1

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini20 – 326ExtracellularSequence analysisAdd BLAST307
Transmembranei327 – 347HelicalSequence analysisAdd BLAST21
Topological domaini348 – 537CytoplasmicSequence analysisAdd BLAST190

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 19Sequence analysisAdd BLAST19
ChainiPRO_000001544920 – 537Interleukin-18 receptor 1Add BLAST518

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi50N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi71N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi107N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi111N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi134N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi141 ↔ 182PROSITE-ProRule annotation
Glycosylationi189N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi194N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi200N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi233N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi234 ↔ 296PROSITE-ProRule annotation
Glycosylationi295N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

EPDiQ61098
MaxQBiQ61098
PaxDbiQ61098
PRIDEiQ61098

PTM databases

PhosphoSitePlusiQ61098

Expressioni

Gene expression databases

BgeeiENSMUSG00000026070
CleanExiMM_IL18R1
ExpressionAtlasiQ61098 baseline and differential
GenevisibleiQ61098 MM

Interactioni

Subunit structurei

Heterodimer with IL18RAP; within this complex, IL18R1 is involved in ligand-binding and IL18RAP in signaling leading to NF-kappa-B and JNK activation (Probable). Interacts with SLC12A3 in peritoneal macrophages; this interaction is increased by IL18 treatment (PubMed:26099046).1 Publication1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
Slc12a3P591585EBI-13612516,EBI-8366645

Protein-protein interaction databases

IntActiQ61098, 1 interactor
STRINGi10090.ENSMUSP00000085298

Structurei

3D structure databases

ProteinModelPortaliQ61098
SMRiQ61098
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini33 – 102Ig-like C2-type 1Add BLAST70
Domaini134 – 189Ig-like C2-type 2Add BLAST56
Domaini212 – 312Ig-like C2-type 3Add BLAST101
Domaini370 – 519TIRPROSITE-ProRule annotationAdd BLAST150

Sequence similaritiesi

Belongs to the interleukin-1 receptor family.Curated

Keywords - Domaini

Immunoglobulin domain, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IH1W Eukaryota
ENOG410ZKHN LUCA
GeneTreeiENSGT00760000119071
HOGENOMiHOG000113032
HOVERGENiHBG052098
InParanoidiQ61098
KOiK05173
OMAiVLEFWPV
OrthoDBiEOG091G0GXW
PhylomeDBiQ61098
TreeFamiTF325519

Family and domain databases

Gene3Di2.60.40.10, 3 hits
3.40.50.10140, 1 hit
InterProiView protein in InterPro
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR003599 Ig_sub
IPR015621 IL-1_rcpt_fam
IPR000157 TIR_dom
IPR035897 Toll_tir_struct_dom_sf
PANTHERiPTHR11890 PTHR11890, 1 hit
PfamiView protein in Pfam
PF13895 Ig_2, 1 hit
PF01582 TIR, 1 hit
SMARTiView protein in SMART
SM00409 IG, 3 hits
SM00255 TIR, 1 hit
SUPFAMiSSF48726 SSF48726, 2 hits
SSF52200 SSF52200, 1 hit
PROSITEiView protein in PROSITE
PS50835 IG_LIKE, 1 hit
PS50104 TIR, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q61098-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MHHEELILTL CILIVKSASK SCIHRSQIHV VEGEPFYLKP CGISAPVHRN
60 70 80 90 100
ETATMRWFKG SASHEYRELN NRSSPRVTFH DHTLEFWPVE MEDEGTYISQ
110 120 130 140 150
VGNDRRNWTL NVTKRNKHSC FSDKLVTSRD VEVNKSLHIT CKNPNYEELI
160 170 180 190 200
QDTWLYKNCK EISKTPRILK DAEFGDEGYY SCVFSVHHNG TRYNITKTVN
210 220 230 240 250
ITVIEGRSKV TPAILGPKCE KVGVELGKDV ELNCSASLNK DDLFYWSIRK
260 270 280 290 300
EDSSDPNVQE DRKETTTWIS EGKLHASKIL RFQKITENYL NVLYNCTVAN
310 320 330 340 350
EEAIDTKSFV LVRKEIPDIP GHVFTGGVTV LVLASVAAVC IVILCVIYKV
360 370 380 390 400
DLVLFYRRIA ERDETLTDGK TYDAFVSYLK ECHPENKEEY TFAVETLPRV
410 420 430 440 450
LEKQFGYKLC IFERDVVPGG AVVEEIHSLI EKSRRLIIVL SQSYLTNGAR
460 470 480 490 500
RELESGLHEA LVERKIKIIL IEFTPASNIT FLPPSLKLLK SYRVLKWRAD
510 520 530
SPSMNSRFWK NLVYLMPAKA VKPWREESEA RSVLSAP
Length:537
Mass (Da):61,601
Last modified:November 1, 1996 - v1
Checksum:iB119FEA403355458
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural varianti317Missing . 1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U43673 mRNA Translation: AAC52437.1
CCDSiCCDS35549.1
RefSeqiNP_032391.1, NM_008365.2
XP_006495790.1, XM_006495727.3
XP_006495791.1, XM_006495728.3
XP_006495792.1, XM_006495729.3
XP_006495793.1, XM_006495730.3
XP_006495795.1, XM_006495732.3
XP_006495797.1, XM_006495734.3
UniGeneiMm.253664

Genome annotation databases

EnsembliENSMUST00000087983; ENSMUSP00000085298; ENSMUSG00000026070
ENSMUST00000108044; ENSMUSP00000103679; ENSMUSG00000026070
ENSMUST00000195684; ENSMUSP00000142070; ENSMUSG00000026070
GeneIDi16182
KEGGimmu:16182
UCSCiuc011wjz.1 mouse

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiIL18R_MOUSE
AccessioniPrimary (citable) accession number: Q61098
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 6, 2002
Last sequence update: November 1, 1996
Last modified: May 23, 2018
This is version 148 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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