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Protein

Interleukin-18 receptor 1

Gene

Il18r1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Receptor for interleukin 18 (IL-18). Binding to the agonist leads to the activation of NF-kappa-B.

GO - Molecular functioni

  • interleukin-18 receptor activity Source: MGI

GO - Biological processi

  • interleukin-18-mediated signaling pathway Source: MGI
  • natural killer cell activation Source: MGI
  • positive regulation of interferon-gamma production Source: MGI
  • positive regulation of NF-kappaB import into nucleus Source: MGI
  • T-helper 1 cell differentiation Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

Receptor

Names & Taxonomyi

Protein namesi
Recommended name:
Interleukin-18 receptor 1
Short name:
IL-18R-1
Short name:
IL-18R1
Alternative name(s):
CD218 antigen-like family member A
IL1 receptor-related protein
Short name:
IL-1Rrp
Short name:
IL1R-rp
CD_antigen: CD218a
Gene namesi
Name:Il18r1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589 Componenti: Chromosome 1

Organism-specific databases

MGIiMGI:105383. Il18r1.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini20 – 326307ExtracellularSequence AnalysisAdd
BLAST
Transmembranei327 – 34721HelicalSequence AnalysisAdd
BLAST
Topological domaini348 – 537190CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1919Sequence AnalysisAdd
BLAST
Chaini20 – 537518Interleukin-18 receptor 1PRO_0000015449Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi50 – 501N-linked (GlcNAc...)Sequence Analysis
Glycosylationi71 – 711N-linked (GlcNAc...)Sequence Analysis
Glycosylationi107 – 1071N-linked (GlcNAc...)Sequence Analysis
Glycosylationi111 – 1111N-linked (GlcNAc...)Sequence Analysis
Glycosylationi134 – 1341N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi141 ↔ 182PROSITE-ProRule annotation
Glycosylationi189 – 1891N-linked (GlcNAc...)Sequence Analysis
Glycosylationi194 – 1941N-linked (GlcNAc...)Sequence Analysis
Glycosylationi200 – 2001N-linked (GlcNAc...)Sequence Analysis
Glycosylationi233 – 2331N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi234 ↔ 296PROSITE-ProRule annotation
Glycosylationi295 – 2951N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ61098.
PRIDEiQ61098.

PTM databases

PhosphoSiteiQ61098.

Expressioni

Gene expression databases

BgeeiQ61098.
CleanExiMM_IL18R1.
ExpressionAtlasiQ61098. baseline and differential.
GenevisibleiQ61098. MM.

Interactioni

Subunit structurei

Does not bind IL1A/interleukin-1 alpha or IL1B/interleukin-1 beta.

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000085298.

Structurei

3D structure databases

ProteinModelPortaliQ61098.
SMRiQ61098. Positions 20-314, 370-517.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini33 – 10270Ig-like C2-type 1Add
BLAST
Domaini134 – 18956Ig-like C2-type 2Add
BLAST
Domaini212 – 312101Ig-like C2-type 3Add
BLAST
Domaini370 – 519150TIRPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the interleukin-1 receptor family.Curated
Contains 1 TIR domain.PROSITE-ProRule annotation

Keywords - Domaini

Immunoglobulin domain, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG121812.
GeneTreeiENSGT00760000119071.
HOGENOMiHOG000113032.
HOVERGENiHBG052098.
InParanoidiQ61098.
KOiK05173.
OMAiRGMIIAV.
OrthoDBiEOG7CVPXJ.
PhylomeDBiQ61098.
TreeFamiTF325519.

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
3.40.50.10140. 1 hit.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
IPR015621. IL-1_rcpt_fam.
IPR013151. Immunoglobulin.
IPR000157. TIR_dom.
[Graphical view]
PANTHERiPTHR11890. PTHR11890. 1 hit.
PfamiPF00047. ig. 1 hit.
PF01582. TIR. 1 hit.
[Graphical view]
SMARTiSM00409. IG. 2 hits.
SM00255. TIR. 1 hit.
[Graphical view]
SUPFAMiSSF52200. SSF52200. 1 hit.
PROSITEiPS50835. IG_LIKE. 1 hit.
PS50104. TIR. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q61098-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MHHEELILTL CILIVKSASK SCIHRSQIHV VEGEPFYLKP CGISAPVHRN
60 70 80 90 100
ETATMRWFKG SASHEYRELN NRSSPRVTFH DHTLEFWPVE MEDEGTYISQ
110 120 130 140 150
VGNDRRNWTL NVTKRNKHSC FSDKLVTSRD VEVNKSLHIT CKNPNYEELI
160 170 180 190 200
QDTWLYKNCK EISKTPRILK DAEFGDEGYY SCVFSVHHNG TRYNITKTVN
210 220 230 240 250
ITVIEGRSKV TPAILGPKCE KVGVELGKDV ELNCSASLNK DDLFYWSIRK
260 270 280 290 300
EDSSDPNVQE DRKETTTWIS EGKLHASKIL RFQKITENYL NVLYNCTVAN
310 320 330 340 350
EEAIDTKSFV LVRKEIPDIP GHVFTGGVTV LVLASVAAVC IVILCVIYKV
360 370 380 390 400
DLVLFYRRIA ERDETLTDGK TYDAFVSYLK ECHPENKEEY TFAVETLPRV
410 420 430 440 450
LEKQFGYKLC IFERDVVPGG AVVEEIHSLI EKSRRLIIVL SQSYLTNGAR
460 470 480 490 500
RELESGLHEA LVERKIKIIL IEFTPASNIT FLPPSLKLLK SYRVLKWRAD
510 520 530
SPSMNSRFWK NLVYLMPAKA VKPWREESEA RSVLSAP
Length:537
Mass (Da):61,601
Last modified:November 1, 1996 - v1
Checksum:iB119FEA403355458
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti317 – 3171Missing .

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U43673 mRNA. Translation: AAC52437.1.
CCDSiCCDS35549.1.
RefSeqiNP_032391.1. NM_008365.2.
XP_006495790.1. XM_006495727.2.
XP_006495791.1. XM_006495728.2.
XP_006495792.1. XM_006495729.2.
XP_006495793.1. XM_006495730.2.
XP_006495794.1. XM_006495731.2.
XP_006495795.1. XM_006495732.2.
XP_006495796.1. XM_006495733.2.
XP_006495797.1. XM_006495734.2.
UniGeneiMm.253664.

Genome annotation databases

EnsembliENSMUST00000087983; ENSMUSP00000085298; ENSMUSG00000026070.
ENSMUST00000108044; ENSMUSP00000103679; ENSMUSG00000026070.
ENSMUST00000195684; ENSMUSP00000142070; ENSMUSG00000026070.
GeneIDi16182.
KEGGimmu:16182.
UCSCiuc011wjz.1. mouse.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U43673 mRNA. Translation: AAC52437.1.
CCDSiCCDS35549.1.
RefSeqiNP_032391.1. NM_008365.2.
XP_006495790.1. XM_006495727.2.
XP_006495791.1. XM_006495728.2.
XP_006495792.1. XM_006495729.2.
XP_006495793.1. XM_006495730.2.
XP_006495794.1. XM_006495731.2.
XP_006495795.1. XM_006495732.2.
XP_006495796.1. XM_006495733.2.
XP_006495797.1. XM_006495734.2.
UniGeneiMm.253664.

3D structure databases

ProteinModelPortaliQ61098.
SMRiQ61098. Positions 20-314, 370-517.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000085298.

PTM databases

PhosphoSiteiQ61098.

Proteomic databases

PaxDbiQ61098.
PRIDEiQ61098.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000087983; ENSMUSP00000085298; ENSMUSG00000026070.
ENSMUST00000108044; ENSMUSP00000103679; ENSMUSG00000026070.
ENSMUST00000195684; ENSMUSP00000142070; ENSMUSG00000026070.
GeneIDi16182.
KEGGimmu:16182.
UCSCiuc011wjz.1. mouse.

Organism-specific databases

CTDi8809.
MGIiMGI:105383. Il18r1.

Phylogenomic databases

eggNOGiNOG121812.
GeneTreeiENSGT00760000119071.
HOGENOMiHOG000113032.
HOVERGENiHBG052098.
InParanoidiQ61098.
KOiK05173.
OMAiRGMIIAV.
OrthoDBiEOG7CVPXJ.
PhylomeDBiQ61098.
TreeFamiTF325519.

Miscellaneous databases

NextBioi289065.
PROiQ61098.
SOURCEiSearch...

Gene expression databases

BgeeiQ61098.
CleanExiMM_IL18R1.
ExpressionAtlasiQ61098. baseline and differential.
GenevisibleiQ61098. MM.

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
3.40.50.10140. 1 hit.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
IPR015621. IL-1_rcpt_fam.
IPR013151. Immunoglobulin.
IPR000157. TIR_dom.
[Graphical view]
PANTHERiPTHR11890. PTHR11890. 1 hit.
PfamiPF00047. ig. 1 hit.
PF01582. TIR. 1 hit.
[Graphical view]
SMARTiSM00409. IG. 2 hits.
SM00255. TIR. 1 hit.
[Graphical view]
SUPFAMiSSF52200. SSF52200. 1 hit.
PROSITEiPS50835. IG_LIKE. 1 hit.
PS50104. TIR. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "IL-1Rrp is a novel receptor-like molecule similar to the type I interleukin-1 receptor and its homologues T1/ST2 and IL-1R AcP."
    Parnet P., Garka K.E., Bonnert T.P., Dower S.K., Sims J.E.
    J. Biol. Chem. 271:3967-3970(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANT ALA-317 DEL.

Entry informationi

Entry nameiIL18R_MOUSE
AccessioniPrimary (citable) accession number: Q61098
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 6, 2002
Last sequence update: November 1, 1996
Last modified: June 24, 2015
This is version 128 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.