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Q61098

- IL18R_MOUSE

UniProt

Q61098 - IL18R_MOUSE

Protein

Interleukin-18 receptor 1

Gene

Il18r1

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 122 (01 Oct 2014)
      Sequence version 1 (01 Nov 1996)
      Previous versions | rss
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    Functioni

    Receptor for interleukin 18 (IL-18). Binding to the agonist leads to the activation of NF-kappa-B.

    GO - Molecular functioni

    1. interleukin-18 receptor activity Source: MGI

    GO - Biological processi

    1. interleukin-18-mediated signaling pathway Source: MGI
    2. natural killer cell activation Source: MGI
    3. positive regulation of interferon-gamma production Source: MGI
    4. positive regulation of NF-kappaB import into nucleus Source: MGI
    5. T-helper 1 cell differentiation Source: MGI

    Keywords - Molecular functioni

    Receptor

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Interleukin-18 receptor 1
    Short name:
    IL-18R-1
    Short name:
    IL-18R1
    Alternative name(s):
    CD218 antigen-like family member A
    IL1 receptor-related protein
    Short name:
    IL-1Rrp
    Short name:
    IL1R-rp
    CD_antigen: CD218a
    Gene namesi
    Name:Il18r1
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 1

    Organism-specific databases

    MGIiMGI:105383. Il18r1.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW

    Keywords - Cellular componenti

    Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 1919Sequence AnalysisAdd
    BLAST
    Chaini20 – 537518Interleukin-18 receptor 1PRO_0000015449Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi50 – 501N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi71 – 711N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi107 – 1071N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi111 – 1111N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi134 – 1341N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi141 ↔ 182PROSITE-ProRule annotation
    Glycosylationi189 – 1891N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi194 – 1941N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi200 – 2001N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi233 – 2331N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi234 ↔ 296PROSITE-ProRule annotation
    Glycosylationi295 – 2951N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    PaxDbiQ61098.
    PRIDEiQ61098.

    PTM databases

    PhosphoSiteiQ61098.

    Expressioni

    Gene expression databases

    ArrayExpressiQ61098.
    BgeeiQ61098.
    CleanExiMM_IL18R1.
    GenevestigatoriQ61098.

    Interactioni

    Subunit structurei

    Does not bind IL1A/interleukin-1 alpha or IL1B/interleukin-1 beta.

    Structurei

    3D structure databases

    ProteinModelPortaliQ61098.
    SMRiQ61098. Positions 24-305, 370-517.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini20 – 326307ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini348 – 537190CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei327 – 34721HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini33 – 10270Ig-like C2-type 1Add
    BLAST
    Domaini134 – 18956Ig-like C2-type 2Add
    BLAST
    Domaini212 – 312101Ig-like C2-type 3Add
    BLAST
    Domaini370 – 519150TIRPROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Belongs to the interleukin-1 receptor family.Curated
    Contains 1 TIR domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Immunoglobulin domain, Repeat, Signal, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG121812.
    GeneTreeiENSGT00680000099639.
    HOGENOMiHOG000113032.
    HOVERGENiHBG052098.
    InParanoidiQ61098.
    KOiK05173.
    OMAiRGMIIAV.
    OrthoDBiEOG7CVPXJ.
    PhylomeDBiQ61098.
    TreeFamiTF325519.

    Family and domain databases

    Gene3Di2.60.40.10. 1 hit.
    3.40.50.10140. 1 hit.
    InterProiIPR007110. Ig-like_dom.
    IPR013783. Ig-like_fold.
    IPR003599. Ig_sub.
    IPR015621. IL-1_rcpt_fam.
    IPR013151. Immunoglobulin.
    IPR000157. TIR_dom.
    [Graphical view]
    PANTHERiPTHR11890. PTHR11890. 1 hit.
    PfamiPF00047. ig. 1 hit.
    PF01582. TIR. 1 hit.
    [Graphical view]
    SMARTiSM00409. IG. 2 hits.
    SM00255. TIR. 1 hit.
    [Graphical view]
    SUPFAMiSSF52200. SSF52200. 1 hit.
    PROSITEiPS50835. IG_LIKE. 1 hit.
    PS50104. TIR. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q61098-1 [UniParc]FASTAAdd to Basket

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    MHHEELILTL CILIVKSASK SCIHRSQIHV VEGEPFYLKP CGISAPVHRN    50
    ETATMRWFKG SASHEYRELN NRSSPRVTFH DHTLEFWPVE MEDEGTYISQ 100
    VGNDRRNWTL NVTKRNKHSC FSDKLVTSRD VEVNKSLHIT CKNPNYEELI 150
    QDTWLYKNCK EISKTPRILK DAEFGDEGYY SCVFSVHHNG TRYNITKTVN 200
    ITVIEGRSKV TPAILGPKCE KVGVELGKDV ELNCSASLNK DDLFYWSIRK 250
    EDSSDPNVQE DRKETTTWIS EGKLHASKIL RFQKITENYL NVLYNCTVAN 300
    EEAIDTKSFV LVRKEIPDIP GHVFTGGVTV LVLASVAAVC IVILCVIYKV 350
    DLVLFYRRIA ERDETLTDGK TYDAFVSYLK ECHPENKEEY TFAVETLPRV 400
    LEKQFGYKLC IFERDVVPGG AVVEEIHSLI EKSRRLIIVL SQSYLTNGAR 450
    RELESGLHEA LVERKIKIIL IEFTPASNIT FLPPSLKLLK SYRVLKWRAD 500
    SPSMNSRFWK NLVYLMPAKA VKPWREESEA RSVLSAP 537
    Length:537
    Mass (Da):61,601
    Last modified:November 1, 1996 - v1
    Checksum:iB119FEA403355458
    GO

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti317 – 3171Missing.

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U43673 mRNA. Translation: AAC52437.1.
    CCDSiCCDS35549.1.
    RefSeqiNP_032391.1. NM_008365.2.
    XP_006495790.1. XM_006495727.1.
    XP_006495791.1. XM_006495728.1.
    XP_006495792.1. XM_006495729.1.
    XP_006495793.1. XM_006495730.1.
    XP_006495794.1. XM_006495731.1.
    XP_006495795.1. XM_006495732.1.
    XP_006495796.1. XM_006495733.1.
    XP_006495797.1. XM_006495734.1.
    UniGeneiMm.253664.

    Genome annotation databases

    EnsembliENSMUST00000087983; ENSMUSP00000085298; ENSMUSG00000026070.
    ENSMUST00000108044; ENSMUSP00000103679; ENSMUSG00000026070.
    GeneIDi16182.
    KEGGimmu:16182.
    UCSCiuc011wjz.1. mouse.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U43673 mRNA. Translation: AAC52437.1 .
    CCDSi CCDS35549.1.
    RefSeqi NP_032391.1. NM_008365.2.
    XP_006495790.1. XM_006495727.1.
    XP_006495791.1. XM_006495728.1.
    XP_006495792.1. XM_006495729.1.
    XP_006495793.1. XM_006495730.1.
    XP_006495794.1. XM_006495731.1.
    XP_006495795.1. XM_006495732.1.
    XP_006495796.1. XM_006495733.1.
    XP_006495797.1. XM_006495734.1.
    UniGenei Mm.253664.

    3D structure databases

    ProteinModelPortali Q61098.
    SMRi Q61098. Positions 24-305, 370-517.
    ModBasei Search...
    MobiDBi Search...

    PTM databases

    PhosphoSitei Q61098.

    Proteomic databases

    PaxDbi Q61098.
    PRIDEi Q61098.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000087983 ; ENSMUSP00000085298 ; ENSMUSG00000026070 .
    ENSMUST00000108044 ; ENSMUSP00000103679 ; ENSMUSG00000026070 .
    GeneIDi 16182.
    KEGGi mmu:16182.
    UCSCi uc011wjz.1. mouse.

    Organism-specific databases

    CTDi 8809.
    MGIi MGI:105383. Il18r1.

    Phylogenomic databases

    eggNOGi NOG121812.
    GeneTreei ENSGT00680000099639.
    HOGENOMi HOG000113032.
    HOVERGENi HBG052098.
    InParanoidi Q61098.
    KOi K05173.
    OMAi RGMIIAV.
    OrthoDBi EOG7CVPXJ.
    PhylomeDBi Q61098.
    TreeFami TF325519.

    Miscellaneous databases

    NextBioi 289065.
    PROi Q61098.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q61098.
    Bgeei Q61098.
    CleanExi MM_IL18R1.
    Genevestigatori Q61098.

    Family and domain databases

    Gene3Di 2.60.40.10. 1 hit.
    3.40.50.10140. 1 hit.
    InterProi IPR007110. Ig-like_dom.
    IPR013783. Ig-like_fold.
    IPR003599. Ig_sub.
    IPR015621. IL-1_rcpt_fam.
    IPR013151. Immunoglobulin.
    IPR000157. TIR_dom.
    [Graphical view ]
    PANTHERi PTHR11890. PTHR11890. 1 hit.
    Pfami PF00047. ig. 1 hit.
    PF01582. TIR. 1 hit.
    [Graphical view ]
    SMARTi SM00409. IG. 2 hits.
    SM00255. TIR. 1 hit.
    [Graphical view ]
    SUPFAMi SSF52200. SSF52200. 1 hit.
    PROSITEi PS50835. IG_LIKE. 1 hit.
    PS50104. TIR. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "IL-1Rrp is a novel receptor-like molecule similar to the type I interleukin-1 receptor and its homologues T1/ST2 and IL-1R AcP."
      Parnet P., Garka K.E., Bonnert T.P., Dower S.K., Sims J.E.
      J. Biol. Chem. 271:3967-3970(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANT ALA-317 DEL.

    Entry informationi

    Entry nameiIL18R_MOUSE
    AccessioniPrimary (citable) accession number: Q61098
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 6, 2002
    Last sequence update: November 1, 1996
    Last modified: October 1, 2014
    This is version 122 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3