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Protein

Myeloblastin

Gene

Prtn3

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Polymorphonuclear leukocyte serine protease that degrades elastin, fibronectin, laminin, vitronectin, and collagen types I, III, and IV (in vitro) and causes emphysema when administered by tracheal insufflation to hamsters.By similarity

Catalytic activityi

Hydrolysis of proteins, including elastin, by preferential cleavage: -Ala-|-Xaa- > -Val-|-Xaa-.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei73Charge relay systemBy similarity1
Active sitei120Charge relay systemBy similarity1
Active sitei205Charge relay systemBy similarity1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protease, Serine protease

Keywords - Biological processi

Collagen degradation

Enzyme and pathway databases

BRENDAi3.4.21.76. 3474.

Protein family/group databases

MEROPSiS01.134.

Names & Taxonomyi

Protein namesi
Recommended name:
Myeloblastin (EC:3.4.21.76)
Alternative name(s):
Proteinase 3
Short name:
PR-3
Gene namesi
Name:Prtn3
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Unplaced

Organism-specific databases

MGIiMGI:893580. Prtn3.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Pathology & Biotechi

Chemistry databases

ChEMBLiCHEMBL5384.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 27By similarityAdd BLAST27
PropeptideiPRO_000002771028 – 29By similarity2
ChainiPRO_000002771130 – 250MyeloblastinAdd BLAST221
PropeptideiPRO_0000027712251 – 254By similarity4

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi58 ↔ 74PROSITE-ProRule annotation
Glycosylationi127N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi154 ↔ 211PROSITE-ProRule annotation
Glycosylationi176N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi184 ↔ 190PROSITE-ProRule annotation
Disulfide bondi201 ↔ 226PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein, Zymogen

Proteomic databases

MaxQBiQ61096.
PaxDbiQ61096.
PeptideAtlasiQ61096.
PRIDEiQ61096.

Expressioni

Gene expression databases

BgeeiENSMUSG00000057729.
CleanExiMM_PRTN3.

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

IntActiQ61096. 1 interactor.
MINTiMINT-4108835.
STRINGi10090.ENSMUSP00000006679.

Chemistry databases

BindingDBiQ61096.

Structurei

3D structure databases

ProteinModelPortaliQ61096.
SMRiQ61096.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini30 – 250Peptidase S1PROSITE-ProRule annotationAdd BLAST221

Sequence similaritiesi

Belongs to the peptidase S1 family. Elastase subfamily.PROSITE-ProRule annotation
Contains 1 peptidase S1 domain.PROSITE-ProRule annotation

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG3627. Eukaryota.
COG5640. LUCA.
HOGENOMiHOG000251820.
HOVERGENiHBG013304.
InParanoidiQ61096.
KOiK01350.
PhylomeDBiQ61096.
TreeFamiTF335284.

Family and domain databases

CDDicd00190. Tryp_SPc. 1 hit.
InterProiIPR009003. Peptidase_S1_PA.
IPR001314. Peptidase_S1A.
IPR001254. Trypsin_dom.
IPR018114. TRYPSIN_HIS.
IPR033116. TRYPSIN_SER.
[Graphical view]
PfamiPF00089. Trypsin. 1 hit.
[Graphical view]
PRINTSiPR00722. CHYMOTRYPSIN.
SMARTiSM00020. Tryp_SPc. 1 hit.
[Graphical view]
SUPFAMiSSF50494. SSF50494. 1 hit.
PROSITEiPS50240. TRYPSIN_DOM. 1 hit.
PS00134. TRYPSIN_HIS. 1 hit.
PS00135. TRYPSIN_SER. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q61096-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSGSYPSPKG IHPFLLLALV VGGAVQASKI VGGHEARPHS RPYVASLQLS
60 70 80 90 100
RFPGSHFCGG TLIHPRFVLT AAHCLQDISW QLVTVVLGAH DLLSSEPEQQ
110 120 130 140 150
KFTISQVFQN NYNPEENLND VLLLQLNRTA SLGKEVAVAS LPQQDQTLSQ
160 170 180 190 200
GTQCLAMGWG RLGTQAPTPR VLQELNVTVV TFLCREHNVC TLVPRRAAGI
210 220 230 240 250
CFGDSGGPLI CNGILHGVDS FVIRECASLQ FPDFFARVSM YVDWIQNVLR

GAEP
Length:254
Mass (Da):27,626
Last modified:August 1, 1999 - v2
Checksum:i00CEB989A3CB79CA
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti2S → A in AAB58055 (PubMed:9187364).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF082186 Genomic DNA. Translation: AAC79701.1.
U97073 mRNA. Translation: AAB58055.1.
U43525 mRNA. Translation: AAB67271.1.
CCDSiCCDS23993.1.
RefSeqiNP_035308.2. NM_011178.2.
UniGeneiMm.2364.

Genome annotation databases

GeneIDi19152.
KEGGimmu:19152.
UCSCiuc007gah.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF082186 Genomic DNA. Translation: AAC79701.1.
U97073 mRNA. Translation: AAB58055.1.
U43525 mRNA. Translation: AAB67271.1.
CCDSiCCDS23993.1.
RefSeqiNP_035308.2. NM_011178.2.
UniGeneiMm.2364.

3D structure databases

ProteinModelPortaliQ61096.
SMRiQ61096.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ61096. 1 interactor.
MINTiMINT-4108835.
STRINGi10090.ENSMUSP00000006679.

Chemistry databases

BindingDBiQ61096.
ChEMBLiCHEMBL5384.

Protein family/group databases

MEROPSiS01.134.

Proteomic databases

MaxQBiQ61096.
PaxDbiQ61096.
PeptideAtlasiQ61096.
PRIDEiQ61096.

Protocols and materials databases

DNASUi19152.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi19152.
KEGGimmu:19152.
UCSCiuc007gah.1. mouse.

Organism-specific databases

CTDi5657.
MGIiMGI:893580. Prtn3.

Phylogenomic databases

eggNOGiKOG3627. Eukaryota.
COG5640. LUCA.
HOGENOMiHOG000251820.
HOVERGENiHBG013304.
InParanoidiQ61096.
KOiK01350.
PhylomeDBiQ61096.
TreeFamiTF335284.

Enzyme and pathway databases

BRENDAi3.4.21.76. 3474.

Miscellaneous databases

ChiTaRSiPrtn3. mouse.
PROiQ61096.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000057729.
CleanExiMM_PRTN3.

Family and domain databases

CDDicd00190. Tryp_SPc. 1 hit.
InterProiIPR009003. Peptidase_S1_PA.
IPR001314. Peptidase_S1A.
IPR001254. Trypsin_dom.
IPR018114. TRYPSIN_HIS.
IPR033116. TRYPSIN_SER.
[Graphical view]
PfamiPF00089. Trypsin. 1 hit.
[Graphical view]
PRINTSiPR00722. CHYMOTRYPSIN.
SMARTiSM00020. Tryp_SPc. 1 hit.
[Graphical view]
SUPFAMiSSF50494. SSF50494. 1 hit.
PROSITEiPS50240. TRYPSIN_DOM. 1 hit.
PS00134. TRYPSIN_HIS. 1 hit.
PS00135. TRYPSIN_SER. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiPRTN3_MOUSE
AccessioniPrimary (citable) accession number: Q61096
Secondary accession number(s): O08809
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 30, 2002
Last sequence update: August 1, 1999
Last modified: November 2, 2016
This is version 125 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. Peptidase families
    Classification of peptidase families and list of entries
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.