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Q61096

- PRTN3_MOUSE

UniProt

Q61096 - PRTN3_MOUSE

Protein

Myeloblastin

Gene

Prtn3

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 106 (01 Oct 2014)
      Sequence version 2 (01 Aug 1999)
      Previous versions | rss
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    Functioni

    Polymorphonuclear leukocyte serine protease that degrades elastin, fibronectin, laminin, vitronectin, and collagen types I, III, and IV (in vitro) and causes emphysema when administered by tracheal insufflation to hamsters.By similarity

    Catalytic activityi

    Hydrolysis of proteins, including elastin, by preferential cleavage: -Ala-|-Xaa- > -Val-|-Xaa-.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei73 – 731Charge relay systemBy similarity
    Active sitei120 – 1201Charge relay systemBy similarity
    Active sitei205 – 2051Charge relay systemBy similarity

    GO - Molecular functioni

    1. serine-type endopeptidase activity Source: InterPro

    GO - Biological processi

    1. collagen catabolic process Source: UniProtKB-KW
    2. mature dendritic cell differentiation Source: Ensembl
    3. negative regulation of phagocytosis Source: Ensembl

    Keywords - Molecular functioni

    Hydrolase, Protease, Serine protease

    Keywords - Biological processi

    Collagen degradation

    Enzyme and pathway databases

    BRENDAi3.4.21.76. 3474.

    Protein family/group databases

    MEROPSiS01.134.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Myeloblastin (EC:3.4.21.76)
    Alternative name(s):
    Proteinase 3
    Short name:
    PR-3
    Gene namesi
    Name:Prtn3
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 10

    Organism-specific databases

    MGIiMGI:893580. Prtn3.

    Subcellular locationi

    GO - Cellular componenti

    1. cytosol Source: Ensembl
    2. extracellular matrix Source: Ensembl
    3. plasma membrane Source: Ensembl

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2727By similarityAdd
    BLAST
    Propeptidei28 – 292By similarityPRO_0000027710
    Chaini30 – 250221MyeloblastinPRO_0000027711Add
    BLAST
    Propeptidei251 – 2544By similarityPRO_0000027712

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi58 ↔ 74PROSITE-ProRule annotation
    Glycosylationi127 – 1271N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi154 ↔ 211PROSITE-ProRule annotation
    Glycosylationi176 – 1761N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi184 ↔ 190PROSITE-ProRule annotation
    Disulfide bondi201 ↔ 226PROSITE-ProRule annotation

    Keywords - PTMi

    Disulfide bond, Glycoprotein, Zymogen

    Proteomic databases

    PaxDbiQ61096.
    PRIDEiQ61096.

    Expressioni

    Gene expression databases

    ArrayExpressiQ61096.
    BgeeiQ61096.
    CleanExiMM_PRTN3.
    GenevestigatoriQ61096.

    Interactioni

    Protein-protein interaction databases

    IntActiQ61096. 1 interaction.
    MINTiMINT-4108835.

    Structurei

    3D structure databases

    ProteinModelPortaliQ61096.
    SMRiQ61096. Positions 30-250.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini30 – 250221Peptidase S1PROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Belongs to the peptidase S1 family. Elastase subfamily.PROSITE-ProRule annotation
    Contains 1 peptidase S1 domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiCOG5640.
    GeneTreeiENSGT00700000104045.
    HOGENOMiHOG000251820.
    HOVERGENiHBG013304.
    InParanoidiQ61096.
    KOiK01350.
    OrthoDBiEOG7MKW6Q.
    PhylomeDBiQ61096.
    TreeFamiTF335284.

    Family and domain databases

    InterProiIPR001254. Peptidase_S1.
    IPR018114. Peptidase_S1_AS.
    IPR001314. Peptidase_S1A.
    IPR009003. Trypsin-like_Pept_dom.
    [Graphical view]
    PfamiPF00089. Trypsin. 1 hit.
    [Graphical view]
    PRINTSiPR00722. CHYMOTRYPSIN.
    SMARTiSM00020. Tryp_SPc. 1 hit.
    [Graphical view]
    SUPFAMiSSF50494. SSF50494. 1 hit.
    PROSITEiPS50240. TRYPSIN_DOM. 1 hit.
    PS00134. TRYPSIN_HIS. 1 hit.
    PS00135. TRYPSIN_SER. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q61096-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSGSYPSPKG IHPFLLLALV VGGAVQASKI VGGHEARPHS RPYVASLQLS    50
    RFPGSHFCGG TLIHPRFVLT AAHCLQDISW QLVTVVLGAH DLLSSEPEQQ 100
    KFTISQVFQN NYNPEENLND VLLLQLNRTA SLGKEVAVAS LPQQDQTLSQ 150
    GTQCLAMGWG RLGTQAPTPR VLQELNVTVV TFLCREHNVC TLVPRRAAGI 200
    CFGDSGGPLI CNGILHGVDS FVIRECASLQ FPDFFARVSM YVDWIQNVLR 250
    GAEP 254
    Length:254
    Mass (Da):27,626
    Last modified:August 1, 1999 - v2
    Checksum:i00CEB989A3CB79CA
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti2 – 21S → A in AAB58055. (PubMed:9187364)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF082186 Genomic DNA. Translation: AAC79701.1.
    U97073 mRNA. Translation: AAB58055.1.
    U43525 mRNA. Translation: AAB67271.1.
    CCDSiCCDS23993.1.
    RefSeqiNP_035308.2. NM_011178.2.
    UniGeneiMm.2364.

    Genome annotation databases

    EnsembliENSMUST00000006679; ENSMUSP00000006679; ENSMUSG00000057729.
    GeneIDi19152.
    KEGGimmu:19152.
    UCSCiuc007gah.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF082186 Genomic DNA. Translation: AAC79701.1 .
    U97073 mRNA. Translation: AAB58055.1 .
    U43525 mRNA. Translation: AAB67271.1 .
    CCDSi CCDS23993.1.
    RefSeqi NP_035308.2. NM_011178.2.
    UniGenei Mm.2364.

    3D structure databases

    ProteinModelPortali Q61096.
    SMRi Q61096. Positions 30-250.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    IntActi Q61096. 1 interaction.
    MINTi MINT-4108835.

    Chemistry

    BindingDBi Q61096.
    ChEMBLi CHEMBL5384.

    Protein family/group databases

    MEROPSi S01.134.

    Proteomic databases

    PaxDbi Q61096.
    PRIDEi Q61096.

    Protocols and materials databases

    DNASUi 19152.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000006679 ; ENSMUSP00000006679 ; ENSMUSG00000057729 .
    GeneIDi 19152.
    KEGGi mmu:19152.
    UCSCi uc007gah.1. mouse.

    Organism-specific databases

    CTDi 5657.
    MGIi MGI:893580. Prtn3.

    Phylogenomic databases

    eggNOGi COG5640.
    GeneTreei ENSGT00700000104045.
    HOGENOMi HOG000251820.
    HOVERGENi HBG013304.
    InParanoidi Q61096.
    KOi K01350.
    OrthoDBi EOG7MKW6Q.
    PhylomeDBi Q61096.
    TreeFami TF335284.

    Enzyme and pathway databases

    BRENDAi 3.4.21.76. 3474.

    Miscellaneous databases

    ChiTaRSi PRTN3. mouse.
    NextBioi 295792.
    PROi Q61096.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q61096.
    Bgeei Q61096.
    CleanExi MM_PRTN3.
    Genevestigatori Q61096.

    Family and domain databases

    InterProi IPR001254. Peptidase_S1.
    IPR018114. Peptidase_S1_AS.
    IPR001314. Peptidase_S1A.
    IPR009003. Trypsin-like_Pept_dom.
    [Graphical view ]
    Pfami PF00089. Trypsin. 1 hit.
    [Graphical view ]
    PRINTSi PR00722. CHYMOTRYPSIN.
    SMARTi SM00020. Tryp_SPc. 1 hit.
    [Graphical view ]
    SUPFAMi SSF50494. SSF50494. 1 hit.
    PROSITEi PS50240. TRYPSIN_DOM. 1 hit.
    PS00134. TRYPSIN_HIS. 1 hit.
    PS00135. TRYPSIN_SER. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Characterization and localization of the genes for mouse proteinase-3 (Prtn3) and neutrophil elastase (Ela2)."
      Sturrock A., Franklin K.F., Wu S.-Q., Hoidal J.R.
      Cytogenet. Cell Genet. 83:104-108(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: 129/SvJ.
    2. "Cloning and functional expression of the murine homologue of proteinase 3: implications for the design of murine models of vasculitis."
      Jenne D.E., Froehlich L., Hummel A.M., Specks U.
      FEBS Lett. 408:187-190(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: 129/Sv.
    3. "Characterization of cDNA clones encoding mouse proteinase 3 (myeloblastine) and cathepsin G."
      Aveskogh M., Lutzelschwab C., Huang M.R., Hellman L.
      Immunogenetics 46:181-191(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 2-254.
      Strain: BALB/c.

    Entry informationi

    Entry nameiPRTN3_MOUSE
    AccessioniPrimary (citable) accession number: Q61096
    Secondary accession number(s): O08809
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: August 30, 2002
    Last sequence update: August 1, 1999
    Last modified: October 1, 2014
    This is version 106 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. Peptidase families
      Classification of peptidase families and list of entries
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3