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Q61096 (PRTN3_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 103. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Myeloblastin

EC=3.4.21.76
Alternative name(s):
Proteinase 3
Short name=PR-3
Gene names
Name:Prtn3
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length254 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Polymorphonuclear leukocyte serine protease that degrades elastin, fibronectin, laminin, vitronectin, and collagen types I, III, and IV (in vitro) and causes emphysema when administered by tracheal insufflation to hamsters By similarity.

Catalytic activity

Hydrolysis of proteins, including elastin, by preferential cleavage: -Ala-|-Xaa- > -Val-|-Xaa-.

Sequence similarities

Belongs to the peptidase S1 family. Elastase subfamily.

Contains 1 peptidase S1 domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2727 By similarity
Propeptide28 – 292 By similarity
PRO_0000027710
Chain30 – 250221Myeloblastin
PRO_0000027711
Propeptide251 – 2544 By similarity
PRO_0000027712

Regions

Domain30 – 250221Peptidase S1

Sites

Active site731Charge relay system By similarity
Active site1201Charge relay system By similarity
Active site2051Charge relay system By similarity

Amino acid modifications

Glycosylation1271N-linked (GlcNAc...) Potential
Glycosylation1761N-linked (GlcNAc...) Potential
Disulfide bond58 ↔ 74 By similarity
Disulfide bond154 ↔ 211 By similarity
Disulfide bond184 ↔ 190 By similarity
Disulfide bond201 ↔ 226 By similarity

Experimental info

Sequence conflict21S → A in AAB58055. Ref.2

Sequences

Sequence LengthMass (Da)Tools
Q61096 [UniParc].

Last modified August 1, 1999. Version 2.
Checksum: 00CEB989A3CB79CA

FASTA25427,626
        10         20         30         40         50         60 
MSGSYPSPKG IHPFLLLALV VGGAVQASKI VGGHEARPHS RPYVASLQLS RFPGSHFCGG 

        70         80         90        100        110        120 
TLIHPRFVLT AAHCLQDISW QLVTVVLGAH DLLSSEPEQQ KFTISQVFQN NYNPEENLND 

       130        140        150        160        170        180 
VLLLQLNRTA SLGKEVAVAS LPQQDQTLSQ GTQCLAMGWG RLGTQAPTPR VLQELNVTVV 

       190        200        210        220        230        240 
TFLCREHNVC TLVPRRAAGI CFGDSGGPLI CNGILHGVDS FVIRECASLQ FPDFFARVSM 

       250 
YVDWIQNVLR GAEP 

« Hide

References

[1]"Characterization and localization of the genes for mouse proteinase-3 (Prtn3) and neutrophil elastase (Ela2)."
Sturrock A., Franklin K.F., Wu S.-Q., Hoidal J.R.
Cytogenet. Cell Genet. 83:104-108(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: 129/SvJ.
[2]"Cloning and functional expression of the murine homologue of proteinase 3: implications for the design of murine models of vasculitis."
Jenne D.E., Froehlich L., Hummel A.M., Specks U.
FEBS Lett. 408:187-190(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Strain: 129/Sv.
[3]"Characterization of cDNA clones encoding mouse proteinase 3 (myeloblastine) and cathepsin G."
Aveskogh M., Lutzelschwab C., Huang M.R., Hellman L.
Immunogenetics 46:181-191(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 2-254.
Strain: BALB/c.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF082186 Genomic DNA. Translation: AAC79701.1.
U97073 mRNA. Translation: AAB58055.1.
U43525 mRNA. Translation: AAB67271.1.
RefSeqNP_035308.2. NM_011178.2.
UniGeneMm.2364.

3D structure databases

ProteinModelPortalQ61096.
SMRQ61096. Positions 30-250.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

IntActQ61096. 1 interaction.
MINTMINT-4108835.

Chemistry

BindingDBQ61096.
ChEMBLCHEMBL5384.

Protein family/group databases

MEROPSS01.134.

Proteomic databases

PaxDbQ61096.
PRIDEQ61096.

Protocols and materials databases

DNASU19152.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000006679; ENSMUSP00000006679; ENSMUSG00000057729.
GeneID19152.
KEGGmmu:19152.
UCSCuc007gah.1. mouse.

Organism-specific databases

CTD5657.
MGIMGI:893580. Prtn3.

Phylogenomic databases

eggNOGCOG5640.
GeneTreeENSGT00700000104045.
HOGENOMHOG000251820.
HOVERGENHBG013304.
InParanoidQ61096.
KOK01350.
OrthoDBEOG7MKW6Q.
PhylomeDBQ61096.
TreeFamTF335284.

Enzyme and pathway databases

BRENDA3.4.21.76. 3474.

Gene expression databases

ArrayExpressQ61096.
BgeeQ61096.
CleanExMM_PRTN3.
GenevestigatorQ61096.

Family and domain databases

InterProIPR001254. Peptidase_S1.
IPR018114. Peptidase_S1_AS.
IPR001314. Peptidase_S1A.
IPR009003. Trypsin-like_Pept_dom.
[Graphical view]
PfamPF00089. Trypsin. 1 hit.
[Graphical view]
PRINTSPR00722. CHYMOTRYPSIN.
SMARTSM00020. Tryp_SPc. 1 hit.
[Graphical view]
SUPFAMSSF50494. SSF50494. 1 hit.
PROSITEPS50240. TRYPSIN_DOM. 1 hit.
PS00134. TRYPSIN_HIS. 1 hit.
PS00135. TRYPSIN_SER. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSPRTN3. mouse.
NextBio295792.
PROQ61096.
SOURCESearch...

Entry information

Entry namePRTN3_MOUSE
AccessionPrimary (citable) accession number: Q61096
Secondary accession number(s): O08809
Entry history
Integrated into UniProtKB/Swiss-Prot: August 30, 2002
Last sequence update: August 1, 1999
Last modified: April 16, 2014
This is version 103 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Peptidase families

Classification of peptidase families and list of entries

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot