Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Q61090

- FZD7_MOUSE

UniProt

Q61090 - FZD7_MOUSE

Protein

Frizzled-7

Gene

Fzd7

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 116 (01 Oct 2014)
      Sequence version 2 (03 Oct 2012)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Receptor for Wnt proteins. Most of frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to involve interactions with G-proteins. May be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues. Activation by Wnt8 induces expression of beta-catenin target genes.2 Publications

    GO - Molecular functioni

    1. G-protein coupled receptor activity Source: UniProtKB-KW
    2. PDZ domain binding Source: RefGenome
    3. protein binding Source: IntAct
    4. Wnt-activated receptor activity Source: MGI
    5. Wnt-protein binding Source: MGI

    GO - Biological processi

    1. axonogenesis Source: RefGenome
    2. brain development Source: RefGenome
    3. canonical Wnt signaling pathway Source: MGI
    4. epithelial cell differentiation Source: RefGenome
    5. gonad development Source: RefGenome
    6. G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger Source: RefGenome
    7. mesenchymal to epithelial transition Source: Ensembl
    8. negative regulation of cell-substrate adhesion Source: BHF-UCL
    9. negative regulation of ectodermal cell fate specification Source: Ensembl
    10. non-canonical Wnt signaling pathway Source: MGI
    11. non-canonical Wnt signaling pathway via JNK cascade Source: Ensembl
    12. positive regulation of epithelial cell proliferation involved in wound healing Source: Ensembl
    13. positive regulation of phosphorylation Source: Ensembl
    14. positive regulation of transcription, DNA-templated Source: Ensembl
    15. regulation of catenin import into nucleus Source: Ensembl
    16. regulation of transcription from RNA polymerase II promoter Source: RefGenome
    17. skeletal muscle satellite cell maintenance involved in skeletal muscle regeneration Source: MGI
    18. somatic stem cell division Source: MGI
    19. substrate adhesion-dependent cell spreading Source: MGI
    20. T cell differentiation in thymus Source: MGI
    21. vasculature development Source: RefGenome
    22. Wnt signaling pathway, calcium modulating pathway Source: RefGenome

    Keywords - Molecular functioni

    Developmental protein, G-protein coupled receptor, Receptor, Transducer

    Keywords - Biological processi

    Wnt signaling pathway

    Enzyme and pathway databases

    ReactomeiREACT_214043. PCP/CE pathway.

    Protein family/group databases

    MEROPSiI93.001.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Frizzled-7
    Short name:
    Fz-7
    Short name:
    mFz7
    Gene namesi
    Name:Fzd7
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 1

    Organism-specific databases

    MGIiMGI:108570. Fzd7.

    Subcellular locationi

    GO - Cellular componenti

    1. apical part of cell Source: RefGenome
    2. cytoplasm Source: RefGenome
    3. integral component of membrane Source: UniProtKB-KW
    4. neuron projection membrane Source: RefGenome
    5. plasma membrane Source: BHF-UCL

    Keywords - Cellular componenti

    Cell membrane, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 3232Sequence AnalysisAdd
    BLAST
    Chaini33 – 572540Frizzled-7PRO_0000012997Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi49 ↔ 110PROSITE-ProRule annotation
    Disulfide bondi57 ↔ 103PROSITE-ProRule annotation
    Glycosylationi63 – 631N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi94 ↔ 131PROSITE-ProRule annotation
    Disulfide bondi120 ↔ 160PROSITE-ProRule annotation
    Disulfide bondi124 ↔ 148PROSITE-ProRule annotation
    Glycosylationi164 – 1641N-linked (GlcNAc...)Sequence Analysis

    Post-translational modificationi

    Ubiquitinated by ZNRF3, leading to its degradation by the proteasome.By similarity

    Keywords - PTMi

    Disulfide bond, Glycoprotein, Ubl conjugation

    Proteomic databases

    PRIDEiQ61090.

    PTM databases

    PhosphoSiteiQ61090.

    Expressioni

    Gene expression databases

    CleanExiMM_FZD7.
    GenevestigatoriQ61090.

    Interactioni

    Subunit structurei

    Interacts with MAGI3 and DVL1. Interacts with MYOC By similarity.By similarity

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    Dlg4Q621084EBI-8473104,EBI-300895

    Protein-protein interaction databases

    IntActiQ61090. 4 interactions.
    MINTiMINT-1780171.

    Structurei

    3D structure databases

    ProteinModelPortaliQ61090.
    SMRiQ61090. Positions 49-155, 228-563.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini33 – 254222ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini276 – 28611CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini308 – 33427ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini356 – 37722CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini399 – 42123ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini443 – 46826CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini490 – 52637ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini548 – 57225CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei255 – 27521Helical; Name=1Sequence AnalysisAdd
    BLAST
    Transmembranei287 – 30721Helical; Name=2Sequence AnalysisAdd
    BLAST
    Transmembranei335 – 35521Helical; Name=3Sequence AnalysisAdd
    BLAST
    Transmembranei378 – 39821Helical; Name=4Sequence AnalysisAdd
    BLAST
    Transmembranei422 – 44221Helical; Name=5Sequence AnalysisAdd
    BLAST
    Transmembranei469 – 48921Helical; Name=6Sequence AnalysisAdd
    BLAST
    Transmembranei527 – 54721Helical; Name=7Sequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini44 – 163120FZPROSITE-ProRule annotationAdd
    BLAST

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi550 – 5556Lys-Thr-X-X-X-Trp motif, mediates interaction with the PDZ domain of Dvl family membersBy similarity
    Motifi570 – 5723PDZ-binding

    Domaini

    Lys-Thr-X-X-X-Trp motif interacts with the PDZ doman of Dvl (Disheveled) family members and is involved in the activation of the Wnt/beta-catenin signaling pathway.By similarity
    The FZ domain is involved in binding with Wnt ligands.By similarity

    Sequence similaritiesi

    Contains 1 FZ (frizzled) domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Signal, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG257258.
    GeneTreeiENSGT00740000114899.
    HOVERGENiHBG006977.
    InParanoidiQ61090.
    KOiK02432.
    OMAiCVERFSE.
    OrthoDBiEOG7M3J01.
    TreeFamiTF317907.

    Family and domain databases

    Gene3Di1.10.2000.10. 1 hit.
    InterProiIPR000539. Frizzled.
    IPR015526. Frizzled/SFRP.
    IPR020067. Frizzled_dom.
    IPR026552. FZD7.
    IPR017981. GPCR_2-like.
    [Graphical view]
    PANTHERiPTHR11309. PTHR11309. 1 hit.
    PTHR11309:SF31. PTHR11309:SF31. 1 hit.
    PfamiPF01534. Frizzled. 1 hit.
    PF01392. Fz. 1 hit.
    [Graphical view]
    PRINTSiPR00489. FRIZZLED.
    SMARTiSM00063. FRI. 1 hit.
    [Graphical view]
    SUPFAMiSSF63501. SSF63501. 1 hit.
    PROSITEiPS50038. FZ. 1 hit.
    PS50261. G_PROTEIN_RECEP_F2_4. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q61090-1 [UniParc]FASTAAdd to Basket

    « Hide

    MRGPGTAASH SPLGLCALVL ALLGALPTDT RAQPYHGEKG ISVPDHGFCQ    50
    PISIPLCTDI AYNQTILPNL LGHTNQEDAG LEVHQFYPLV KVQCSPELRF 100
    FLCSMYAPVC TVLDQAIPPC RSLCERARQG CEALMNKFGF QWPERLRCEN 150
    FPVHGAGEIC VGQNTSDGSG GAGGSPTAYP TAPYLPDPPF TAMSPSDGRG 200
    RLSFPFSCPR QLKVPPYLGY RFLGERDCGA PCEPGRANGL MYFKEEERRF 250
    ARLWVGVWSV LCCASTLFTV LTYLVDMRRF SYPERPIIFL SGCYFMVAVA 300
    HVAGFLLEDR AVCVERFSDD GYRTVAQGTK KEGCTILFMV LYFFGMASSI 350
    WWVILSLTWF LAAGMKWGHE AIEANSQYFH LAAWAVPAVK TITILAMGQV 400
    DGDLLSGVCY VGLSSVDALR GFVLAPLFVY LFIGTSFLLA GFVSLFRIRT 450
    IMKHDGTKTE KLEKLMVRIG VFSVLYTVPA TIVLACYFYE QAFREHWERT 500
    WLLQTCKSYA VPCPPGHFSP MSPDFTVFMI KYLMTMIVGI TTGFWIWSGK 550
    TLQSWRRFYH RLSHSSKGET AV 572
    Length:572
    Mass (Da):63,733
    Last modified:October 3, 2012 - v2
    Checksum:iD0B7DF37B9736183
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti262 – 2621C → S in AAC52432. (PubMed:8626800)Curated
    Sequence conflicti516 – 5161G → R in AAC52432. (PubMed:8626800)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U43320 mRNA. Translation: AAC52432.1.
    AC132574 Genomic DNA. No translation available.
    CH466548 Genomic DNA. Translation: EDL00127.1.
    CCDSiCCDS14985.1.
    RefSeqiNP_032083.3. NM_008057.3.
    UniGeneiMm.297906.

    Genome annotation databases

    EnsembliENSMUST00000037105; ENSMUSP00000041825; ENSMUSG00000041075.
    ENSMUST00000114246; ENSMUSP00000109884; ENSMUSG00000041075.
    GeneIDi14369.
    KEGGimmu:14369.
    UCSCiuc011wlq.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U43320 mRNA. Translation: AAC52432.1 .
    AC132574 Genomic DNA. No translation available.
    CH466548 Genomic DNA. Translation: EDL00127.1 .
    CCDSi CCDS14985.1.
    RefSeqi NP_032083.3. NM_008057.3.
    UniGenei Mm.297906.

    3D structure databases

    ProteinModelPortali Q61090.
    SMRi Q61090. Positions 49-155, 228-563.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    IntActi Q61090. 4 interactions.
    MINTi MINT-1780171.

    Protein family/group databases

    MEROPSi I93.001.
    GPCRDBi Search...

    PTM databases

    PhosphoSitei Q61090.

    Proteomic databases

    PRIDEi Q61090.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000037105 ; ENSMUSP00000041825 ; ENSMUSG00000041075 .
    ENSMUST00000114246 ; ENSMUSP00000109884 ; ENSMUSG00000041075 .
    GeneIDi 14369.
    KEGGi mmu:14369.
    UCSCi uc011wlq.1. mouse.

    Organism-specific databases

    CTDi 8324.
    MGIi MGI:108570. Fzd7.

    Phylogenomic databases

    eggNOGi NOG257258.
    GeneTreei ENSGT00740000114899.
    HOVERGENi HBG006977.
    InParanoidi Q61090.
    KOi K02432.
    OMAi CVERFSE.
    OrthoDBi EOG7M3J01.
    TreeFami TF317907.

    Enzyme and pathway databases

    Reactomei REACT_214043. PCP/CE pathway.

    Miscellaneous databases

    NextBioi 285849.
    PROi Q61090.
    SOURCEi Search...

    Gene expression databases

    CleanExi MM_FZD7.
    Genevestigatori Q61090.

    Family and domain databases

    Gene3Di 1.10.2000.10. 1 hit.
    InterProi IPR000539. Frizzled.
    IPR015526. Frizzled/SFRP.
    IPR020067. Frizzled_dom.
    IPR026552. FZD7.
    IPR017981. GPCR_2-like.
    [Graphical view ]
    PANTHERi PTHR11309. PTHR11309. 1 hit.
    PTHR11309:SF31. PTHR11309:SF31. 1 hit.
    Pfami PF01534. Frizzled. 1 hit.
    PF01392. Fz. 1 hit.
    [Graphical view ]
    PRINTSi PR00489. FRIZZLED.
    SMARTi SM00063. FRI. 1 hit.
    [Graphical view ]
    SUPFAMi SSF63501. SSF63501. 1 hit.
    PROSITEi PS50038. FZ. 1 hit.
    PS50261. G_PROTEIN_RECEP_F2_4. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "A large family of putative transmembrane receptors homologous to the product of the Drosophila tissue polarity gene frizzled."
      Wang Y., Macke J.P., Abella B.S., Andreasson K., Worley P., Gilbert D.J., Copeland N.G., Jenkins N.A., Nathans J.
      J. Biol. Chem. 271:4468-4476(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: C57BL/6J.
    3. Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
      Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. "Protein kinase C is differentially stimulated by Wnt and Frizzled homologs in a G-protein-dependent manner."
      Sheldahl L.C., Park M., Malbon C.C., Moon R.T.
      Curr. Biol. 9:695-698(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: COUPLING TO BETA-CATENIN PATHWAY.
    5. "Biochemical characterization of Wnt-frizzled interactions using a soluble, biologically active vertebrate Wnt protein."
      Hsieh J.C., Rattner A., Smallwood P.M., Nathans J.
      Proc. Natl. Acad. Sci. U.S.A. 96:3546-3551(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, SUBCELLULAR LOCATION.
    6. "Characterization of function of three domains in dishevelled-1: DEP domain is responsible for membrane translocation of dishevelled-1."
      Pan W.J., Pang S.Z., Huang T., Guo H.Y., Wu D., Li L.
      Cell Res. 14:324-330(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, SUBCELLULAR LOCATION, INTERACTION WITH DVL1.
    7. "MAGI-3 is involved in the regulation of the JNK signaling pathway as a scaffold protein for frizzled and Ltap."
      Yao R., Natsume Y., Noda T.
      Oncogene 23:6023-6030(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH MAGI3.

    Entry informationi

    Entry nameiFZD7_MOUSE
    AccessioniPrimary (citable) accession number: Q61090
    Secondary accession number(s): G3X953
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 5, 2001
    Last sequence update: October 3, 2012
    Last modified: October 1, 2014
    This is version 116 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. 7-transmembrane G-linked receptors
      List of 7-transmembrane G-linked receptor entries
    2. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3