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Q61090

- FZD7_MOUSE

UniProt

Q61090 - FZD7_MOUSE

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Protein
Frizzled-7
Gene
Fzd7
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Receptor for Wnt proteins. Most of frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to involve interactions with G-proteins. May be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues. Activation by Wnt8 induces expression of beta-catenin target genes.2 Publications

GO - Molecular functioni

  1. G-protein coupled receptor activity Source: UniProtKB-KW
  2. PDZ domain binding Source: RefGenome
  3. Wnt-activated receptor activity Source: MGI
  4. Wnt-protein binding Source: MGI
  5. protein binding Source: IntAct

GO - Biological processi

  1. G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger Source: RefGenome
  2. T cell differentiation in thymus Source: MGI
  3. Wnt signaling pathway, calcium modulating pathway Source: RefGenome
  4. axonogenesis Source: RefGenome
  5. brain development Source: RefGenome
  6. canonical Wnt signaling pathway Source: MGI
  7. epithelial cell differentiation Source: RefGenome
  8. gonad development Source: RefGenome
  9. mesenchymal to epithelial transition Source: Ensembl
  10. negative regulation of cell-substrate adhesion Source: BHF-UCL
  11. negative regulation of ectodermal cell fate specification Source: Ensembl
  12. non-canonical Wnt signaling pathway Source: MGI
  13. non-canonical Wnt signaling pathway via JNK cascade Source: Ensembl
  14. positive regulation of epithelial cell proliferation involved in wound healing Source: Ensembl
  15. positive regulation of phosphorylation Source: Ensembl
  16. positive regulation of transcription, DNA-templated Source: Ensembl
  17. regulation of catenin import into nucleus Source: Ensembl
  18. regulation of transcription from RNA polymerase II promoter Source: RefGenome
  19. satellite cell maintenance involved in skeletal muscle regeneration Source: MGI
  20. somatic stem cell division Source: MGI
  21. substrate adhesion-dependent cell spreading Source: MGI
  22. vasculature development Source: RefGenome
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein, G-protein coupled receptor, Receptor, Transducer

Keywords - Biological processi

Wnt signaling pathway

Enzyme and pathway databases

ReactomeiREACT_214043. PCP/CE pathway.

Protein family/group databases

MEROPSiI93.001.

Names & Taxonomyi

Protein namesi
Recommended name:
Frizzled-7
Short name:
Fz-7
Short name:
mFz7
Gene namesi
Name:Fzd7
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 1

Organism-specific databases

MGIiMGI:108570. Fzd7.

Subcellular locationi

Membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein 2 Publications

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini33 – 254222Extracellular Reviewed prediction
Add
BLAST
Transmembranei255 – 27521Helical; Name=1; Reviewed prediction
Add
BLAST
Topological domaini276 – 28611Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei287 – 30721Helical; Name=2; Reviewed prediction
Add
BLAST
Topological domaini308 – 33427Extracellular Reviewed prediction
Add
BLAST
Transmembranei335 – 35521Helical; Name=3; Reviewed prediction
Add
BLAST
Topological domaini356 – 37722Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei378 – 39821Helical; Name=4; Reviewed prediction
Add
BLAST
Topological domaini399 – 42123Extracellular Reviewed prediction
Add
BLAST
Transmembranei422 – 44221Helical; Name=5; Reviewed prediction
Add
BLAST
Topological domaini443 – 46826Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei469 – 48921Helical; Name=6; Reviewed prediction
Add
BLAST
Topological domaini490 – 52637Extracellular Reviewed prediction
Add
BLAST
Transmembranei527 – 54721Helical; Name=7; Reviewed prediction
Add
BLAST
Topological domaini548 – 57225Cytoplasmic Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. apical part of cell Source: RefGenome
  2. cytoplasm Source: RefGenome
  3. integral component of membrane Source: UniProtKB-KW
  4. neuron projection membrane Source: RefGenome
  5. plasma membrane Source: BHF-UCL
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 3232 Reviewed prediction
Add
BLAST
Chaini33 – 572540Frizzled-7
PRO_0000012997Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi49 ↔ 110 By similarity
Disulfide bondi57 ↔ 103 By similarity
Glycosylationi63 – 631N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi94 ↔ 131 By similarity
Disulfide bondi120 ↔ 160 By similarity
Disulfide bondi124 ↔ 148 By similarity
Glycosylationi164 – 1641N-linked (GlcNAc...) Reviewed prediction

Post-translational modificationi

Ubiquitinated by ZNRF3, leading to its degradation by the proteasome By similarity.

Keywords - PTMi

Disulfide bond, Glycoprotein, Ubl conjugation

Proteomic databases

PRIDEiQ61090.

PTM databases

PhosphoSiteiQ61090.

Expressioni

Gene expression databases

CleanExiMM_FZD7.
GenevestigatoriQ61090.

Interactioni

Subunit structurei

Interacts with MAGI3 and DVL1. Interacts with MYOC By similarity.2 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
Dlg4Q621084EBI-8473104,EBI-300895

Protein-protein interaction databases

IntActiQ61090. 4 interactions.
MINTiMINT-1780171.

Structurei

3D structure databases

ProteinModelPortaliQ61090.
SMRiQ61090. Positions 49-155, 228-563.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini44 – 163120FZ
Add
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi550 – 5556Lys-Thr-X-X-X-Trp motif, mediates interaction with the PDZ domain of Dvl family members By similarity
Motifi570 – 5723PDZ-binding

Domaini

Lys-Thr-X-X-X-Trp motif interacts with the PDZ doman of Dvl (Disheveled) family members and is involved in the activation of the Wnt/beta-catenin signaling pathway By similarity.
The FZ domain is involved in binding with Wnt ligands By similarity.

Sequence similaritiesi

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG257258.
GeneTreeiENSGT00740000114899.
HOVERGENiHBG006977.
InParanoidiQ61090.
KOiK02432.
OMAiCVERFSE.
OrthoDBiEOG7M3J01.
TreeFamiTF317907.

Family and domain databases

Gene3Di1.10.2000.10. 1 hit.
InterProiIPR000539. Frizzled.
IPR015526. Frizzled/SFRP.
IPR020067. Frizzled_dom.
IPR026552. FZD7.
IPR017981. GPCR_2-like.
[Graphical view]
PANTHERiPTHR11309. PTHR11309. 1 hit.
PTHR11309:SF31. PTHR11309:SF31. 1 hit.
PfamiPF01534. Frizzled. 1 hit.
PF01392. Fz. 1 hit.
[Graphical view]
PRINTSiPR00489. FRIZZLED.
SMARTiSM00063. FRI. 1 hit.
[Graphical view]
SUPFAMiSSF63501. SSF63501. 1 hit.
PROSITEiPS50038. FZ. 1 hit.
PS50261. G_PROTEIN_RECEP_F2_4. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q61090-1 [UniParc]FASTAAdd to Basket

« Hide

MRGPGTAASH SPLGLCALVL ALLGALPTDT RAQPYHGEKG ISVPDHGFCQ    50
PISIPLCTDI AYNQTILPNL LGHTNQEDAG LEVHQFYPLV KVQCSPELRF 100
FLCSMYAPVC TVLDQAIPPC RSLCERARQG CEALMNKFGF QWPERLRCEN 150
FPVHGAGEIC VGQNTSDGSG GAGGSPTAYP TAPYLPDPPF TAMSPSDGRG 200
RLSFPFSCPR QLKVPPYLGY RFLGERDCGA PCEPGRANGL MYFKEEERRF 250
ARLWVGVWSV LCCASTLFTV LTYLVDMRRF SYPERPIIFL SGCYFMVAVA 300
HVAGFLLEDR AVCVERFSDD GYRTVAQGTK KEGCTILFMV LYFFGMASSI 350
WWVILSLTWF LAAGMKWGHE AIEANSQYFH LAAWAVPAVK TITILAMGQV 400
DGDLLSGVCY VGLSSVDALR GFVLAPLFVY LFIGTSFLLA GFVSLFRIRT 450
IMKHDGTKTE KLEKLMVRIG VFSVLYTVPA TIVLACYFYE QAFREHWERT 500
WLLQTCKSYA VPCPPGHFSP MSPDFTVFMI KYLMTMIVGI TTGFWIWSGK 550
TLQSWRRFYH RLSHSSKGET AV 572
Length:572
Mass (Da):63,733
Last modified:October 3, 2012 - v2
Checksum:iD0B7DF37B9736183
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti262 – 2621C → S in AAC52432. 1 Publication
Sequence conflicti516 – 5161G → R in AAC52432. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U43320 mRNA. Translation: AAC52432.1.
AC132574 Genomic DNA. No translation available.
CH466548 Genomic DNA. Translation: EDL00127.1.
CCDSiCCDS14985.1.
RefSeqiNP_032083.3. NM_008057.3.
UniGeneiMm.297906.

Genome annotation databases

EnsembliENSMUST00000037105; ENSMUSP00000041825; ENSMUSG00000041075.
ENSMUST00000114246; ENSMUSP00000109884; ENSMUSG00000041075.
GeneIDi14369.
KEGGimmu:14369.
UCSCiuc011wlq.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U43320 mRNA. Translation: AAC52432.1 .
AC132574 Genomic DNA. No translation available.
CH466548 Genomic DNA. Translation: EDL00127.1 .
CCDSi CCDS14985.1.
RefSeqi NP_032083.3. NM_008057.3.
UniGenei Mm.297906.

3D structure databases

ProteinModelPortali Q61090.
SMRi Q61090. Positions 49-155, 228-563.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

IntActi Q61090. 4 interactions.
MINTi MINT-1780171.

Protein family/group databases

MEROPSi I93.001.
GPCRDBi Search...

PTM databases

PhosphoSitei Q61090.

Proteomic databases

PRIDEi Q61090.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000037105 ; ENSMUSP00000041825 ; ENSMUSG00000041075 .
ENSMUST00000114246 ; ENSMUSP00000109884 ; ENSMUSG00000041075 .
GeneIDi 14369.
KEGGi mmu:14369.
UCSCi uc011wlq.1. mouse.

Organism-specific databases

CTDi 8324.
MGIi MGI:108570. Fzd7.

Phylogenomic databases

eggNOGi NOG257258.
GeneTreei ENSGT00740000114899.
HOVERGENi HBG006977.
InParanoidi Q61090.
KOi K02432.
OMAi CVERFSE.
OrthoDBi EOG7M3J01.
TreeFami TF317907.

Enzyme and pathway databases

Reactomei REACT_214043. PCP/CE pathway.

Miscellaneous databases

NextBioi 285849.
PROi Q61090.
SOURCEi Search...

Gene expression databases

CleanExi MM_FZD7.
Genevestigatori Q61090.

Family and domain databases

Gene3Di 1.10.2000.10. 1 hit.
InterProi IPR000539. Frizzled.
IPR015526. Frizzled/SFRP.
IPR020067. Frizzled_dom.
IPR026552. FZD7.
IPR017981. GPCR_2-like.
[Graphical view ]
PANTHERi PTHR11309. PTHR11309. 1 hit.
PTHR11309:SF31. PTHR11309:SF31. 1 hit.
Pfami PF01534. Frizzled. 1 hit.
PF01392. Fz. 1 hit.
[Graphical view ]
PRINTSi PR00489. FRIZZLED.
SMARTi SM00063. FRI. 1 hit.
[Graphical view ]
SUPFAMi SSF63501. SSF63501. 1 hit.
PROSITEi PS50038. FZ. 1 hit.
PS50261. G_PROTEIN_RECEP_F2_4. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "A large family of putative transmembrane receptors homologous to the product of the Drosophila tissue polarity gene frizzled."
    Wang Y., Macke J.P., Abella B.S., Andreasson K., Worley P., Gilbert D.J., Copeland N.G., Jenkins N.A., Nathans J.
    J. Biol. Chem. 271:4468-4476(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  3. Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
    Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "Protein kinase C is differentially stimulated by Wnt and Frizzled homologs in a G-protein-dependent manner."
    Sheldahl L.C., Park M., Malbon C.C., Moon R.T.
    Curr. Biol. 9:695-698(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: COUPLING TO BETA-CATENIN PATHWAY.
  5. "Biochemical characterization of Wnt-frizzled interactions using a soluble, biologically active vertebrate Wnt protein."
    Hsieh J.C., Rattner A., Smallwood P.M., Nathans J.
    Proc. Natl. Acad. Sci. U.S.A. 96:3546-3551(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, SUBCELLULAR LOCATION.
  6. "Characterization of function of three domains in dishevelled-1: DEP domain is responsible for membrane translocation of dishevelled-1."
    Pan W.J., Pang S.Z., Huang T., Guo H.Y., Wu D., Li L.
    Cell Res. 14:324-330(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, SUBCELLULAR LOCATION, INTERACTION WITH DVL1.
  7. "MAGI-3 is involved in the regulation of the JNK signaling pathway as a scaffold protein for frizzled and Ltap."
    Yao R., Natsume Y., Noda T.
    Oncogene 23:6023-6030(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH MAGI3.

Entry informationi

Entry nameiFZD7_MOUSE
AccessioniPrimary (citable) accession number: Q61090
Secondary accession number(s): G3X953
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 5, 2001
Last sequence update: October 3, 2012
Last modified: September 3, 2014
This is version 115 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi