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Protein

Hsp90 co-chaperone Cdc37

Gene

Cdc37

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Co-chaperone that binds to numerous kinases and promotes their interaction with the Hsp90 complex, resulting in stabilization and promotion of their activity. Inhibits HSP90AA1 ATPase activity (By similarity).By similarity1 Publication

GO - Molecular functioni

  • chaperone binding Source: GO_Central
  • heat shock protein binding Source: MGI
  • Hsp90 protein binding Source: MGI
  • kinase binding Source: ParkinsonsUK-UCL
  • protein kinase binding Source: InterPro
  • protein tyrosine kinase activity Source: MGI
  • unfolded protein binding Source: GO_Central

GO - Biological processi

Keywordsi

Molecular functionChaperone

Enzyme and pathway databases

ReactomeiR-MMU-1227986. Signaling by ERBB2.
R-MMU-8863795. Downregulation of ERBB2 signaling.

Names & Taxonomyi

Protein namesi
Recommended name:
Hsp90 co-chaperone Cdc37
Alternative name(s):
Hsp90 chaperone protein kinase-targeting subunit
p50Cdc37
Cleaved into the following chain:
Gene namesi
Name:Cdc37
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 9

Organism-specific databases

MGIiMGI:109531. Cdc37.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00004231981 – 379Hsp90 co-chaperone Cdc37Add BLAST379
Initiator methionineiRemoved; alternateBy similarity
ChainiPRO_00001950582 – 379Hsp90 co-chaperone Cdc37, N-terminally processedAdd BLAST378

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1N-acetylmethionineBy similarity1
Modified residuei2N-acetylvaline; in Hsp90 co-chaperone Cdc37, N-terminally processedBy similarity1
Modified residuei13PhosphoserineBy similarity1
Modified residuei119PhosphothreonineBy similarity1
Modified residuei121PhosphoserineBy similarity1
Modified residuei155N6-acetyllysineBy similarity1
Modified residuei378PhosphoserineBy similarity1

Post-translational modificationi

Constitutively sumoylated by UBE2I.By similarity

Keywords - PTMi

Acetylation, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiQ61081.
MaxQBiQ61081.
PaxDbiQ61081.
PeptideAtlasiQ61081.
PRIDEiQ61081.

PTM databases

iPTMnetiQ61081.
PhosphoSitePlusiQ61081.
SwissPalmiQ61081.

Expressioni

Gene expression databases

BgeeiENSMUSG00000019471.
CleanExiMM_CDC37.
GenevisibleiQ61081. MM.

Interactioni

Subunit structurei

Interacts with HSP90AA1. Forms a complex with Hsp90/HSP90AB1 and CDK6. Interacts with AR, CDK4, CDK6, EIF2AK1 and RB1. Interacts with FLCN, FNIP1 and FNIP2 (By similarity). Interacts with KSR1 (PubMed:10409742).By similarity1 Publication

GO - Molecular functioni

  • chaperone binding Source: GO_Central
  • heat shock protein binding Source: MGI
  • Hsp90 protein binding Source: MGI
  • kinase binding Source: ParkinsonsUK-UCL
  • protein kinase binding Source: InterPro
  • unfolded protein binding Source: GO_Central

Protein-protein interaction databases

BioGridi198626. 24 interactors.
IntActiQ61081. 25 interactors.
MINTiMINT-1848189.
STRINGi10090.ENSMUSP00000019615.

Structurei

3D structure databases

ProteinModelPortaliQ61081.
SMRiQ61081.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the CDC37 family.Curated

Phylogenomic databases

eggNOGiKOG2260. Eukaryota.
ENOG410XTCZ. LUCA.
GeneTreeiENSGT00390000013443.
HOGENOMiHOG000018180.
HOVERGENiHBG056343.
InParanoidiQ61081.
KOiK09554.
OMAiMEEKHDL.
OrthoDBiEOG091G0HL8.
PhylomeDBiQ61081.
TreeFamiTF101059.

Family and domain databases

InterProiView protein in InterPro
IPR004918. Cdc37.
IPR013873. Cdc37_C.
IPR013874. Cdc37_Hsp90-bd.
IPR013855. Cdc37_N_dom.
PANTHERiPTHR12800. PTHR12800. 1 hit.
PfamiView protein in Pfam
PF08564. CDC37_C. 1 hit.
PF08565. CDC37_M. 1 hit.
PF03234. CDC37_N. 1 hit.
SMARTiView protein in SMART
SM01069. CDC37_C. 1 hit.
SM01070. CDC37_M. 1 hit.
SM01071. CDC37_N. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q61081-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVDYSVWDHI EVSDDEDETH PNIDTASLFR WRHQARVERM EQFQKEKEEL
60 70 80 90 100
DRGCRECKRK VAECQRKLKE LEVAESDGQV ELERLRAEAQ QLRKEERSWE
110 120 130 140 150
QKLEDMRKKE KNMPWNVDTL SKDGFSKSMV NTKPEKAEED SEEAREQKHK
160 170 180 190 200
TFVEKYEKQI KHFGMLHRWD DSQKYLSDNV HLVCEETANY LVIWCIDLEV
210 220 230 240 250
EEKCALMEQV AHQTMVMQFI LELAKSLKVD PRACFRQFFT KIKTADHQYM
260 270 280 290 300
EGFKYELEAF KERVRGRAKL RIEKAMKEYE EEERKKRLGP GGLDPVEVYE
310 320 330 340 350
SLPEELQKCF DVKDVQMLQD AISKMDPTDA KYHMQRCIDS GLWVPNSKSG
360 370
EAKEGEEAGP GDPLLEAVPK AGNEKDVSA
Length:379
Mass (Da):44,593
Last modified:November 1, 1996 - v1
Checksum:i847C146B4FE3AAF1
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U43076 mRNA. Translation: AAB18761.1.
AK010494 mRNA. Translation: BAB26984.1.
AK013255 mRNA. Translation: BAB28749.1.
AK145671 mRNA. Translation: BAE26580.1.
AK168651 mRNA. Translation: BAE40508.1.
BC060079 mRNA. Translation: AAH60079.1.
CCDSiCCDS22894.1.
RefSeqiNP_058022.1. NM_016742.4.
UniGeneiMm.32331.

Genome annotation databases

EnsembliENSMUST00000019615; ENSMUSP00000019615; ENSMUSG00000019471.
GeneIDi12539.
KEGGimmu:12539.
UCSCiuc009okg.1. mouse.

Similar proteinsi

Entry informationi

Entry nameiCDC37_MOUSE
AccessioniPrimary (citable) accession number: Q61081
Secondary accession number(s): Q3TGP0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 20, 2002
Last sequence update: November 1, 1996
Last modified: September 27, 2017
This is version 133 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families