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Q61081

- CDC37_MOUSE

UniProt

Q61081 - CDC37_MOUSE

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Protein

Hsp90 co-chaperone Cdc37

Gene

Cdc37

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli

Functioni

Co-chaperone that binds to numerous kinases and promotes their interaction with the Hsp90 complex, resulting in stabilization and promotion of their activity.1 Publication

GO - Molecular functioni

  1. Hsp90 protein binding Source: MGI

GO - Biological processi

  1. regulation of cell cycle Source: Ensembl
  2. regulation of interferon-gamma-mediated signaling pathway Source: MGI
  3. regulation of type I interferon-mediated signaling pathway Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

Chaperone

Enzyme and pathway databases

ReactomeiREACT_188191. Signaling by ERBB2.
REACT_199123. Signaling by constitutively active EGFR.

Names & Taxonomyi

Protein namesi
Recommended name:
Hsp90 co-chaperone Cdc37
Alternative name(s):
Hsp90 chaperone protein kinase-targeting subunit
p50Cdc37
Cleaved into the following chain:
Gene namesi
Name:Cdc37
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 9

Organism-specific databases

MGIiMGI:109531. Cdc37.

Subcellular locationi

GO - Cellular componenti

  1. cytosol Source: MGI
  2. extracellular vesicular exosome Source: Ensembl
  3. protein complex Source: Ensembl
  4. ruffle membrane Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 379379Hsp90 co-chaperone Cdc37PRO_0000195058Add
BLAST
Initiator methioninei1 – 11Removed; alternateBy similarity
Chaini2 – 379378Hsp90 co-chaperone Cdc37, N-terminally processedPRO_0000423198Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei1 – 11N-acetylmethionineBy similarity
Modified residuei2 – 21N-acetylvaline; in Hsp90 co-chaperone Cdc37, N-terminally processedBy similarity
Modified residuei13 – 131PhosphoserineBy similarity
Modified residuei155 – 1551N6-acetyllysineBy similarity
Modified residuei378 – 3781PhosphoserineBy similarity

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

MaxQBiQ61081.
PaxDbiQ61081.
PRIDEiQ61081.

PTM databases

PhosphoSiteiQ61081.

Expressioni

Gene expression databases

BgeeiQ61081.
CleanExiMM_CDC37.
GenevestigatoriQ61081.

Interactioni

Subunit structurei

Forms a complex with Hsp90/HSP90AB1 and CDK6. Interacts with AR, CDK4, CDK6, EIF2AK1 and RB1 (By similarity).By similarity

Protein-protein interaction databases

BioGridi198626. 6 interactions.
IntActiQ61081. 5 interactions.
MINTiMINT-1848189.

Structurei

3D structure databases

ProteinModelPortaliQ61081.
SMRiQ61081. Positions 149-348.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the CDC37 family.Curated

Phylogenomic databases

eggNOGiNOG300020.
GeneTreeiENSGT00390000013443.
HOGENOMiHOG000018180.
HOVERGENiHBG056343.
InParanoidiQ61081.
KOiK09554.
OMAiYHMKRCV.
OrthoDBiEOG73805G.
PhylomeDBiQ61081.
TreeFamiTF101059.

Family and domain databases

InterProiIPR004918. Cdc37.
IPR013873. Cdc37_C.
IPR013874. Cdc37_Hsp90-bd.
IPR013855. Cdc37_N_dom.
[Graphical view]
PANTHERiPTHR12800. PTHR12800. 1 hit.
PfamiPF08564. CDC37_C. 1 hit.
PF08565. CDC37_M. 1 hit.
PF03234. CDC37_N. 2 hits.
[Graphical view]
SMARTiSM01069. CDC37_C. 1 hit.
SM01070. CDC37_M. 1 hit.
SM01071. CDC37_N. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q61081-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MVDYSVWDHI EVSDDEDETH PNIDTASLFR WRHQARVERM EQFQKEKEEL
60 70 80 90 100
DRGCRECKRK VAECQRKLKE LEVAESDGQV ELERLRAEAQ QLRKEERSWE
110 120 130 140 150
QKLEDMRKKE KNMPWNVDTL SKDGFSKSMV NTKPEKAEED SEEAREQKHK
160 170 180 190 200
TFVEKYEKQI KHFGMLHRWD DSQKYLSDNV HLVCEETANY LVIWCIDLEV
210 220 230 240 250
EEKCALMEQV AHQTMVMQFI LELAKSLKVD PRACFRQFFT KIKTADHQYM
260 270 280 290 300
EGFKYELEAF KERVRGRAKL RIEKAMKEYE EEERKKRLGP GGLDPVEVYE
310 320 330 340 350
SLPEELQKCF DVKDVQMLQD AISKMDPTDA KYHMQRCIDS GLWVPNSKSG
360 370
EAKEGEEAGP GDPLLEAVPK AGNEKDVSA
Length:379
Mass (Da):44,593
Last modified:November 1, 1996 - v1
Checksum:i847C146B4FE3AAF1
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U43076 mRNA. Translation: AAB18761.1.
AK010494 mRNA. Translation: BAB26984.1.
AK013255 mRNA. Translation: BAB28749.1.
AK145671 mRNA. Translation: BAE26580.1.
AK168651 mRNA. Translation: BAE40508.1.
BC060079 mRNA. Translation: AAH60079.1.
CCDSiCCDS22894.1.
RefSeqiNP_058022.1. NM_016742.4.
UniGeneiMm.32331.

Genome annotation databases

EnsembliENSMUST00000019615; ENSMUSP00000019615; ENSMUSG00000019471.
GeneIDi12539.
KEGGimmu:12539.
UCSCiuc009okg.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U43076 mRNA. Translation: AAB18761.1 .
AK010494 mRNA. Translation: BAB26984.1 .
AK013255 mRNA. Translation: BAB28749.1 .
AK145671 mRNA. Translation: BAE26580.1 .
AK168651 mRNA. Translation: BAE40508.1 .
BC060079 mRNA. Translation: AAH60079.1 .
CCDSi CCDS22894.1.
RefSeqi NP_058022.1. NM_016742.4.
UniGenei Mm.32331.

3D structure databases

ProteinModelPortali Q61081.
SMRi Q61081. Positions 149-348.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 198626. 6 interactions.
IntActi Q61081. 5 interactions.
MINTi MINT-1848189.

PTM databases

PhosphoSitei Q61081.

Proteomic databases

MaxQBi Q61081.
PaxDbi Q61081.
PRIDEi Q61081.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000019615 ; ENSMUSP00000019615 ; ENSMUSG00000019471 .
GeneIDi 12539.
KEGGi mmu:12539.
UCSCi uc009okg.1. mouse.

Organism-specific databases

CTDi 11140.
MGIi MGI:109531. Cdc37.

Phylogenomic databases

eggNOGi NOG300020.
GeneTreei ENSGT00390000013443.
HOGENOMi HOG000018180.
HOVERGENi HBG056343.
InParanoidi Q61081.
KOi K09554.
OMAi YHMKRCV.
OrthoDBi EOG73805G.
PhylomeDBi Q61081.
TreeFami TF101059.

Enzyme and pathway databases

Reactomei REACT_188191. Signaling by ERBB2.
REACT_199123. Signaling by constitutively active EGFR.

Miscellaneous databases

ChiTaRSi Cdc37. mouse.
NextBioi 281578.
PROi Q61081.
SOURCEi Search...

Gene expression databases

Bgeei Q61081.
CleanExi MM_CDC37.
Genevestigatori Q61081.

Family and domain databases

InterProi IPR004918. Cdc37.
IPR013873. Cdc37_C.
IPR013874. Cdc37_Hsp90-bd.
IPR013855. Cdc37_N_dom.
[Graphical view ]
PANTHERi PTHR12800. PTHR12800. 1 hit.
Pfami PF08564. CDC37_C. 1 hit.
PF08565. CDC37_M. 1 hit.
PF03234. CDC37_N. 2 hits.
[Graphical view ]
SMARTi SM01069. CDC37_C. 1 hit.
SM01070. CDC37_M. 1 hit.
SM01071. CDC37_N. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Mammalian p50Cdc37 is a protein kinase-targeting subunit of Hsp90 that binds and stabilizes Cdk4."
    Stepanova L., Leng X., Parker S.B., Harper J.W.
    Genes Dev. 10:1491-1502(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION.
  2. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Embryo, Embryonic stem cell and Kidney.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6.
    Tissue: Brain.

Entry informationi

Entry nameiCDC37_MOUSE
AccessioniPrimary (citable) accession number: Q61081
Secondary accession number(s): Q3TGP0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 20, 2002
Last sequence update: November 1, 1996
Last modified: November 26, 2014
This is version 105 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3