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Q61081 (CDC37_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 101. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Hsp90 co-chaperone Cdc37
Alternative name(s):
Hsp90 chaperone protein kinase-targeting subunit
p50Cdc37

Cleaved into the following chain:

  1. Hsp90 co-chaperone Cdc37, N-terminally processed
Gene names
Name:Cdc37
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length379 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Co-chaperone that binds to numerous kinases and promotes their interaction with the Hsp90 complex, resulting in stabilization and promotion of their activity. Ref.1

Subunit structure

Forms a complex with Hsp90/HSP90AB1 and CDK6. Interacts with AR, CDK4, CDK6, EIF2AK1 and RB1 By similarity.

Subcellular location

Cytoplasm.

Sequence similarities

Belongs to the CDC37 family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 379379Hsp90 co-chaperone Cdc37
PRO_0000195058
Initiator methionine11Removed; alternate By similarity
Chain2 – 379378Hsp90 co-chaperone Cdc37, N-terminally processed
PRO_0000423198

Amino acid modifications

Modified residue11N-acetylmethionine By similarity
Modified residue21N-acetylvaline; in Hsp90 co-chaperone Cdc37, N-terminally processed By similarity
Modified residue131Phosphoserine By similarity
Modified residue1551N6-acetyllysine By similarity
Modified residue3781Phosphoserine By similarity

Sequences

Sequence LengthMass (Da)Tools
Q61081 [UniParc].

Last modified November 1, 1996. Version 1.
Checksum: 847C146B4FE3AAF1

FASTA37944,593
        10         20         30         40         50         60 
MVDYSVWDHI EVSDDEDETH PNIDTASLFR WRHQARVERM EQFQKEKEEL DRGCRECKRK 

        70         80         90        100        110        120 
VAECQRKLKE LEVAESDGQV ELERLRAEAQ QLRKEERSWE QKLEDMRKKE KNMPWNVDTL 

       130        140        150        160        170        180 
SKDGFSKSMV NTKPEKAEED SEEAREQKHK TFVEKYEKQI KHFGMLHRWD DSQKYLSDNV 

       190        200        210        220        230        240 
HLVCEETANY LVIWCIDLEV EEKCALMEQV AHQTMVMQFI LELAKSLKVD PRACFRQFFT 

       250        260        270        280        290        300 
KIKTADHQYM EGFKYELEAF KERVRGRAKL RIEKAMKEYE EEERKKRLGP GGLDPVEVYE 

       310        320        330        340        350        360 
SLPEELQKCF DVKDVQMLQD AISKMDPTDA KYHMQRCIDS GLWVPNSKSG EAKEGEEAGP 

       370 
GDPLLEAVPK AGNEKDVSA 

« Hide

References

« Hide 'large scale' references
[1]"Mammalian p50Cdc37 is a protein kinase-targeting subunit of Hsp90 that binds and stabilizes Cdk4."
Stepanova L., Leng X., Parker S.B., Harper J.W.
Genes Dev. 10:1491-1502(1996) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION.
[2]"The transcriptional landscape of the mammalian genome."
Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. expand/collapse author list , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: C57BL/6J.
Tissue: Embryo, Embryonic stem cell and Kidney.
[3]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: C57BL/6.
Tissue: Brain.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
U43076 mRNA. Translation: AAB18761.1.
AK010494 mRNA. Translation: BAB26984.1.
AK013255 mRNA. Translation: BAB28749.1.
AK145671 mRNA. Translation: BAE26580.1.
AK168651 mRNA. Translation: BAE40508.1.
BC060079 mRNA. Translation: AAH60079.1.
CCDSCCDS22894.1.
RefSeqNP_058022.1. NM_016742.4.
UniGeneMm.32331.

3D structure databases

ProteinModelPortalQ61081.
SMRQ61081. Positions 149-348.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid198626. 6 interactions.
IntActQ61081. 5 interactions.
MINTMINT-1848189.

PTM databases

PhosphoSiteQ61081.

Proteomic databases

MaxQBQ61081.
PaxDbQ61081.
PRIDEQ61081.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000019615; ENSMUSP00000019615; ENSMUSG00000019471.
GeneID12539.
KEGGmmu:12539.
UCSCuc009okg.1. mouse.

Organism-specific databases

CTD11140.
MGIMGI:109531. Cdc37.

Phylogenomic databases

eggNOGNOG300020.
GeneTreeENSGT00390000013443.
HOGENOMHOG000018180.
HOVERGENHBG056343.
InParanoidQ61081.
KOK09554.
OMAYHMKRCV.
OrthoDBEOG73805G.
PhylomeDBQ61081.
TreeFamTF101059.

Gene expression databases

BgeeQ61081.
CleanExMM_CDC37.
GenevestigatorQ61081.

Family and domain databases

InterProIPR004918. Cdc37.
IPR013873. Cdc37_C.
IPR013874. Cdc37_Hsp90-bd.
IPR013855. Cdc37_N_dom.
[Graphical view]
PANTHERPTHR12800. PTHR12800. 1 hit.
PfamPF08564. CDC37_C. 1 hit.
PF08565. CDC37_M. 1 hit.
PF03234. CDC37_N. 2 hits.
[Graphical view]
SMARTSM01069. CDC37_C. 1 hit.
SM01070. CDC37_M. 1 hit.
SM01071. CDC37_N. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSCDC37. mouse.
NextBio281578.
PROQ61081.
SOURCESearch...

Entry information

Entry nameCDC37_MOUSE
AccessionPrimary (citable) accession number: Q61081
Secondary accession number(s): Q3TGP0
Entry history
Integrated into UniProtKB/Swiss-Prot: June 20, 2002
Last sequence update: November 1, 1996
Last modified: July 9, 2014
This is version 101 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot