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Protein

Hsp90 co-chaperone Cdc37

Gene

Cdc37

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Co-chaperone that binds to numerous kinases and promotes their interaction with the Hsp90 complex, resulting in stabilization and promotion of their activity. Inhibits HSP90AA1 ATPase activity (By similarity).By similarity1 Publication

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionChaperone

Enzyme and pathway databases

ReactomeiR-MMU-1227986 Signaling by ERBB2
R-MMU-8863795 Downregulation of ERBB2 signaling

Names & Taxonomyi

Protein namesi
Recommended name:
Hsp90 co-chaperone Cdc37
Alternative name(s):
Hsp90 chaperone protein kinase-targeting subunit
p50Cdc37
Cleaved into the following chain:
Gene namesi
Name:Cdc37
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 9

Organism-specific databases

MGIiMGI:109531 Cdc37

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001950581 – 379Hsp90 co-chaperone Cdc37Add BLAST379
Initiator methionineiRemoved; alternateBy similarity
ChainiPRO_00004231982 – 379Hsp90 co-chaperone Cdc37, N-terminally processedAdd BLAST378

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1N-acetylmethionineBy similarity1
Modified residuei2N-acetylvaline; in Hsp90 co-chaperone Cdc37, N-terminally processedBy similarity1
Modified residuei13PhosphoserineBy similarity1
Modified residuei119PhosphothreonineBy similarity1
Modified residuei121PhosphoserineBy similarity1
Modified residuei155N6-acetyllysineBy similarity1
Modified residuei378PhosphoserineBy similarity1

Post-translational modificationi

Constitutively sumoylated by UBE2I.By similarity

Keywords - PTMi

Acetylation, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiQ61081
MaxQBiQ61081
PaxDbiQ61081
PeptideAtlasiQ61081
PRIDEiQ61081

PTM databases

iPTMnetiQ61081
PhosphoSitePlusiQ61081
SwissPalmiQ61081

Expressioni

Gene expression databases

BgeeiENSMUSG00000019471
CleanExiMM_CDC37
ExpressionAtlasiQ61081 baseline and differential
GenevisibleiQ61081 MM

Interactioni

Subunit structurei

Probably forms a complex composed of chaperones HSP90 and HSP70, co-chaperones STIP1/HOP, CDC37, PPP5C, PTGES3/p23, TSC1 and client protein TSC2 (By similarity). Probably forms a complex composed of chaperones HSP90 and HSP70, co-chaperones CDC37, PPP5C, TSC1 and client protein TSC2, CDK4, AKT, RAF1 and NR3C1; this complex does not contain co-chaperones STIP1/HOP and PTGES3/p23 (By similarity). Forms a complex with Hsp90/HSP90AB1 and CDK6 (By similarity). Interacts with HSP90AA1 (By similarity). Interacts with AR, CDK4, CDK6 and EIF2AK1 (By similarity). Interacts with RB1 (By similarity). Interacts with KSR1 (PubMed:10409742). Interacts with FLCN, FNIP1 and FNIP2 (By similarity).By similarity1 Publication

GO - Molecular functioni

  • chaperone binding Source: GO_Central
  • heat shock protein binding Source: MGI
  • Hsp90 protein binding Source: MGI
  • kinase binding Source: ParkinsonsUK-UCL
  • protein kinase binding Source: InterPro
  • scaffold protein binding Source: MGI
  • unfolded protein binding Source: GO_Central

Protein-protein interaction databases

BioGridi198626, 25 interactors
IntActiQ61081, 25 interactors
MINTiQ61081
STRINGi10090.ENSMUSP00000019615

Structurei

3D structure databases

ProteinModelPortaliQ61081
SMRiQ61081
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the CDC37 family.Curated

Phylogenomic databases

eggNOGiKOG2260 Eukaryota
ENOG410XTCZ LUCA
GeneTreeiENSGT00390000013443
HOGENOMiHOG000018180
HOVERGENiHBG056343
InParanoidiQ61081
KOiK09554
OMAiMEEKHDL
OrthoDBiEOG091G0HL8
PhylomeDBiQ61081
TreeFamiTF101059

Family and domain databases

Gene3Di1.20.58.610, 1 hit
InterProiView protein in InterPro
IPR004918 Cdc37
IPR013873 Cdc37_C
IPR013874 Cdc37_Hsp90-bd
IPR038189 Cdc37_Hsp90-bd_sf
IPR013855 Cdc37_N_dom
PANTHERiPTHR12800 PTHR12800, 1 hit
PfamiView protein in Pfam
PF08564 CDC37_C, 1 hit
PF08565 CDC37_M, 1 hit
PF03234 CDC37_N, 1 hit
SMARTiView protein in SMART
SM01069 CDC37_C, 1 hit
SM01070 CDC37_M, 1 hit
SM01071 CDC37_N, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q61081-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVDYSVWDHI EVSDDEDETH PNIDTASLFR WRHQARVERM EQFQKEKEEL
60 70 80 90 100
DRGCRECKRK VAECQRKLKE LEVAESDGQV ELERLRAEAQ QLRKEERSWE
110 120 130 140 150
QKLEDMRKKE KNMPWNVDTL SKDGFSKSMV NTKPEKAEED SEEAREQKHK
160 170 180 190 200
TFVEKYEKQI KHFGMLHRWD DSQKYLSDNV HLVCEETANY LVIWCIDLEV
210 220 230 240 250
EEKCALMEQV AHQTMVMQFI LELAKSLKVD PRACFRQFFT KIKTADHQYM
260 270 280 290 300
EGFKYELEAF KERVRGRAKL RIEKAMKEYE EEERKKRLGP GGLDPVEVYE
310 320 330 340 350
SLPEELQKCF DVKDVQMLQD AISKMDPTDA KYHMQRCIDS GLWVPNSKSG
360 370
EAKEGEEAGP GDPLLEAVPK AGNEKDVSA
Length:379
Mass (Da):44,593
Last modified:November 1, 1996 - v1
Checksum:i847C146B4FE3AAF1
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U43076 mRNA Translation: AAB18761.1
AK010494 mRNA Translation: BAB26984.1
AK013255 mRNA Translation: BAB28749.1
AK145671 mRNA Translation: BAE26580.1
AK168651 mRNA Translation: BAE40508.1
BC060079 mRNA Translation: AAH60079.1
CCDSiCCDS22894.1
RefSeqiNP_058022.1, NM_016742.4
UniGeneiMm.32331

Genome annotation databases

EnsembliENSMUST00000019615; ENSMUSP00000019615; ENSMUSG00000019471
GeneIDi12539
KEGGimmu:12539
UCSCiuc009okg.1 mouse

Similar proteinsi

Entry informationi

Entry nameiCDC37_MOUSE
AccessioniPrimary (citable) accession number: Q61081
Secondary accession number(s): Q3TGP0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 20, 2002
Last sequence update: November 1, 1996
Last modified: April 25, 2018
This is version 138 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health