Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Q61081

- CDC37_MOUSE

UniProt

Q61081 - CDC37_MOUSE

Protein

Hsp90 co-chaperone Cdc37

Gene

Cdc37

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 103 (01 Oct 2014)
      Sequence version 1 (01 Nov 1996)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Co-chaperone that binds to numerous kinases and promotes their interaction with the Hsp90 complex, resulting in stabilization and promotion of their activity.1 Publication

    GO - Molecular functioni

    1. Hsp90 protein binding Source: MGI

    GO - Biological processi

    1. regulation of cell cycle Source: Ensembl
    2. regulation of interferon-gamma-mediated signaling pathway Source: MGI
    3. regulation of type I interferon-mediated signaling pathway Source: MGI

    Keywords - Molecular functioni

    Chaperone

    Enzyme and pathway databases

    ReactomeiREACT_188191. Signaling by ERBB2.
    REACT_199123. Signaling by constitutively active EGFR.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Hsp90 co-chaperone Cdc37
    Alternative name(s):
    Hsp90 chaperone protein kinase-targeting subunit
    p50Cdc37
    Cleaved into the following chain:
    Gene namesi
    Name:Cdc37
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 9

    Organism-specific databases

    MGIiMGI:109531. Cdc37.

    Subcellular locationi

    GO - Cellular componenti

    1. cytosol Source: MGI
    2. protein complex Source: Ensembl
    3. ruffle membrane Source: Ensembl

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 379379Hsp90 co-chaperone Cdc37PRO_0000195058Add
    BLAST
    Initiator methioninei1 – 11Removed; alternateBy similarity
    Chaini2 – 379378Hsp90 co-chaperone Cdc37, N-terminally processedPRO_0000423198Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei1 – 11N-acetylmethionineBy similarity
    Modified residuei2 – 21N-acetylvaline; in Hsp90 co-chaperone Cdc37, N-terminally processedBy similarity
    Modified residuei13 – 131PhosphoserineBy similarity
    Modified residuei155 – 1551N6-acetyllysineBy similarity
    Modified residuei378 – 3781PhosphoserineBy similarity

    Keywords - PTMi

    Acetylation, Phosphoprotein

    Proteomic databases

    MaxQBiQ61081.
    PaxDbiQ61081.
    PRIDEiQ61081.

    PTM databases

    PhosphoSiteiQ61081.

    Expressioni

    Gene expression databases

    BgeeiQ61081.
    CleanExiMM_CDC37.
    GenevestigatoriQ61081.

    Interactioni

    Subunit structurei

    Forms a complex with Hsp90/HSP90AB1 and CDK6. Interacts with AR, CDK4, CDK6, EIF2AK1 and RB1 By similarity.By similarity

    Protein-protein interaction databases

    BioGridi198626. 6 interactions.
    IntActiQ61081. 5 interactions.
    MINTiMINT-1848189.

    Structurei

    3D structure databases

    ProteinModelPortaliQ61081.
    SMRiQ61081. Positions 149-348.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the CDC37 family.Curated

    Phylogenomic databases

    eggNOGiNOG300020.
    GeneTreeiENSGT00390000013443.
    HOGENOMiHOG000018180.
    HOVERGENiHBG056343.
    InParanoidiQ61081.
    KOiK09554.
    OMAiYHMKRCV.
    OrthoDBiEOG73805G.
    PhylomeDBiQ61081.
    TreeFamiTF101059.

    Family and domain databases

    InterProiIPR004918. Cdc37.
    IPR013873. Cdc37_C.
    IPR013874. Cdc37_Hsp90-bd.
    IPR013855. Cdc37_N_dom.
    [Graphical view]
    PANTHERiPTHR12800. PTHR12800. 1 hit.
    PfamiPF08564. CDC37_C. 1 hit.
    PF08565. CDC37_M. 1 hit.
    PF03234. CDC37_N. 2 hits.
    [Graphical view]
    SMARTiSM01069. CDC37_C. 1 hit.
    SM01070. CDC37_M. 1 hit.
    SM01071. CDC37_N. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q61081-1 [UniParc]FASTAAdd to Basket

    « Hide

    MVDYSVWDHI EVSDDEDETH PNIDTASLFR WRHQARVERM EQFQKEKEEL    50
    DRGCRECKRK VAECQRKLKE LEVAESDGQV ELERLRAEAQ QLRKEERSWE 100
    QKLEDMRKKE KNMPWNVDTL SKDGFSKSMV NTKPEKAEED SEEAREQKHK 150
    TFVEKYEKQI KHFGMLHRWD DSQKYLSDNV HLVCEETANY LVIWCIDLEV 200
    EEKCALMEQV AHQTMVMQFI LELAKSLKVD PRACFRQFFT KIKTADHQYM 250
    EGFKYELEAF KERVRGRAKL RIEKAMKEYE EEERKKRLGP GGLDPVEVYE 300
    SLPEELQKCF DVKDVQMLQD AISKMDPTDA KYHMQRCIDS GLWVPNSKSG 350
    EAKEGEEAGP GDPLLEAVPK AGNEKDVSA 379
    Length:379
    Mass (Da):44,593
    Last modified:November 1, 1996 - v1
    Checksum:i847C146B4FE3AAF1
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U43076 mRNA. Translation: AAB18761.1.
    AK010494 mRNA. Translation: BAB26984.1.
    AK013255 mRNA. Translation: BAB28749.1.
    AK145671 mRNA. Translation: BAE26580.1.
    AK168651 mRNA. Translation: BAE40508.1.
    BC060079 mRNA. Translation: AAH60079.1.
    CCDSiCCDS22894.1.
    RefSeqiNP_058022.1. NM_016742.4.
    UniGeneiMm.32331.

    Genome annotation databases

    EnsembliENSMUST00000019615; ENSMUSP00000019615; ENSMUSG00000019471.
    GeneIDi12539.
    KEGGimmu:12539.
    UCSCiuc009okg.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U43076 mRNA. Translation: AAB18761.1 .
    AK010494 mRNA. Translation: BAB26984.1 .
    AK013255 mRNA. Translation: BAB28749.1 .
    AK145671 mRNA. Translation: BAE26580.1 .
    AK168651 mRNA. Translation: BAE40508.1 .
    BC060079 mRNA. Translation: AAH60079.1 .
    CCDSi CCDS22894.1.
    RefSeqi NP_058022.1. NM_016742.4.
    UniGenei Mm.32331.

    3D structure databases

    ProteinModelPortali Q61081.
    SMRi Q61081. Positions 149-348.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 198626. 6 interactions.
    IntActi Q61081. 5 interactions.
    MINTi MINT-1848189.

    PTM databases

    PhosphoSitei Q61081.

    Proteomic databases

    MaxQBi Q61081.
    PaxDbi Q61081.
    PRIDEi Q61081.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000019615 ; ENSMUSP00000019615 ; ENSMUSG00000019471 .
    GeneIDi 12539.
    KEGGi mmu:12539.
    UCSCi uc009okg.1. mouse.

    Organism-specific databases

    CTDi 11140.
    MGIi MGI:109531. Cdc37.

    Phylogenomic databases

    eggNOGi NOG300020.
    GeneTreei ENSGT00390000013443.
    HOGENOMi HOG000018180.
    HOVERGENi HBG056343.
    InParanoidi Q61081.
    KOi K09554.
    OMAi YHMKRCV.
    OrthoDBi EOG73805G.
    PhylomeDBi Q61081.
    TreeFami TF101059.

    Enzyme and pathway databases

    Reactomei REACT_188191. Signaling by ERBB2.
    REACT_199123. Signaling by constitutively active EGFR.

    Miscellaneous databases

    ChiTaRSi CDC37. mouse.
    NextBioi 281578.
    PROi Q61081.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q61081.
    CleanExi MM_CDC37.
    Genevestigatori Q61081.

    Family and domain databases

    InterProi IPR004918. Cdc37.
    IPR013873. Cdc37_C.
    IPR013874. Cdc37_Hsp90-bd.
    IPR013855. Cdc37_N_dom.
    [Graphical view ]
    PANTHERi PTHR12800. PTHR12800. 1 hit.
    Pfami PF08564. CDC37_C. 1 hit.
    PF08565. CDC37_M. 1 hit.
    PF03234. CDC37_N. 2 hits.
    [Graphical view ]
    SMARTi SM01069. CDC37_C. 1 hit.
    SM01070. CDC37_M. 1 hit.
    SM01071. CDC37_N. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Mammalian p50Cdc37 is a protein kinase-targeting subunit of Hsp90 that binds and stabilizes Cdk4."
      Stepanova L., Leng X., Parker S.B., Harper J.W.
      Genes Dev. 10:1491-1502(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION.
    2. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6J.
      Tissue: Embryo, Embryonic stem cell and Kidney.
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6.
      Tissue: Brain.

    Entry informationi

    Entry nameiCDC37_MOUSE
    AccessioniPrimary (citable) accession number: Q61081
    Secondary accession number(s): Q3TGP0
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: June 20, 2002
    Last sequence update: November 1, 1996
    Last modified: October 1, 2014
    This is version 103 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3