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Q61080

- FOXF1_MOUSE

UniProt

Q61080 - FOXF1_MOUSE

Protein

Forkhead box protein F1

Gene

Foxf1

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 117 (01 Oct 2014)
      Sequence version 2 (26 May 2009)
      Previous versions | rss
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    Functioni

    Probable transcription activator for a number of lung-specific genes.By similarity

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    DNA bindingi47 – 13892Fork-headPROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. DNA binding Source: MGI
    2. sequence-specific DNA binding Source: InterPro
    3. sequence-specific DNA binding transcription factor activity Source: InterPro
    4. transcription regulatory region DNA binding Source: MGI

    GO - Biological processi

    1. branching involved in open tracheal system development Source: Ensembl
    2. cardiac left ventricle morphogenesis Source: Ensembl
    3. cellular response to cytokine stimulus Source: MGI
    4. cellular response to organic cyclic compound Source: MGI
    5. detection of wounding Source: MGI
    6. determination of left/right symmetry Source: MGI
    7. ductus arteriosus closure Source: Ensembl
    8. embryonic digestive tract development Source: MGI
    9. embryonic ectodermal digestive tract morphogenesis Source: Ensembl
    10. embryonic foregut morphogenesis Source: MGI
    11. endocardial cushion development Source: Ensembl
    12. epithelial cell differentiation involved in mammary gland alveolus development Source: MGI
    13. epithelial tube branching involved in lung morphogenesis Source: MGI
    14. establishment of epithelial cell apical/basal polarity Source: MGI
    15. extracellular matrix organization Source: MGI
    16. in utero embryonic development Source: MGI
    17. lateral mesodermal cell differentiation Source: MGI
    18. lung alveolus development Source: MGI
    19. lung development Source: MGI
    20. lung lobe morphogenesis Source: MGI
    21. lung morphogenesis Source: MGI
    22. lung vasculature development Source: Ensembl
    23. mesenchyme migration Source: MGI
    24. mesoderm development Source: MGI
    25. midgut development Source: Ensembl
    26. negative regulation of inflammatory response Source: MGI
    27. negative regulation of mast cell degranulation Source: MGI
    28. negative regulation of transcription from RNA polymerase II promoter Source: MGI
    29. organ morphogenesis Source: MGI
    30. pancreas development Source: Ensembl
    31. positive regulation of cell migration Source: MGI
    32. positive regulation of cell-substrate adhesion Source: MGI
    33. positive regulation of mesenchymal cell proliferation Source: MGI
    34. positive regulation of transcription from RNA polymerase II promoter Source: MGI
    35. regulation of smooth muscle cell differentiation Source: MGI
    36. right lung morphogenesis Source: MGI
    37. single organismal cell-cell adhesion Source: MGI
    38. smoothened signaling pathway Source: MGI
    39. smooth muscle cell differentiation Source: MGI
    40. somitogenesis Source: MGI
    41. trachea development Source: MGI
    42. transcription, DNA-templated Source: UniProtKB-KW
    43. ureter development Source: Ensembl
    44. vasculogenesis Source: MGI
    45. venous blood vessel development Source: Ensembl

    Keywords - Molecular functioni

    Activator

    Keywords - Biological processi

    Transcription, Transcription regulation

    Keywords - Ligandi

    DNA-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Forkhead box protein F1
    Alternative name(s):
    Forkhead-related protein FKHL5
    Forkhead-related transcription factor 1
    Short name:
    FREAC-1
    Hepatocyte nuclear factor 3 forkhead homolog 8
    Short name:
    HFH-8
    Gene namesi
    Name:Foxf1
    Synonyms:Fkhl5, Foxf1a, Freac1, Hfh8
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 8

    Organism-specific databases

    MGIiMGI:1347470. Foxf1.

    Subcellular locationi

    Nucleus PROSITE-ProRule annotation

    GO - Cellular componenti

    1. nucleus Source: MGI

    Keywords - Cellular componenti

    Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 378378Forkhead box protein F1PRO_0000091833Add
    BLAST

    Proteomic databases

    PRIDEiQ61080.

    PTM databases

    PhosphoSiteiQ61080.

    Expressioni

    Tissue specificityi

    Expressed primarily in lung in alveolar type II pneumocyte cells, and to a lesser extent in placenta, stomach, intestine and colon.2 Publications

    Gene expression databases

    BgeeiQ61080.
    CleanExiMM_FOXF1A.
    GenevestigatoriQ61080.

    Interactioni

    Protein-protein interaction databases

    STRINGi10090.ENSMUSP00000057481.

    Structurei

    3D structure databases

    ProteinModelPortaliQ61080.
    SMRiQ61080. Positions 48-137.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domaini

    Activation domains C-terminal of (and distinct from) the forkhead domains are necessary for transcriptional activation.By similarity

    Sequence similaritiesi

    Contains 1 fork-head DNA-binding domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiCOG5025.
    GeneTreeiENSGT00750000117270.
    HOGENOMiHOG000060124.
    HOVERGENiHBG051644.
    InParanoidiB2RSC1.
    KOiK09399.
    OMAiMTAEVQQ.
    OrthoDBiEOG7D59PX.
    PhylomeDBiQ61080.
    TreeFamiTF351598.

    Family and domain databases

    Gene3Di1.10.10.10. 1 hit.
    InterProiIPR001766. TF_fork_head.
    IPR018122. TF_fork_head_CS.
    IPR011991. WHTH_DNA-bd_dom.
    [Graphical view]
    PfamiPF00250. Fork_head. 1 hit.
    [Graphical view]
    PRINTSiPR00053. FORKHEAD.
    SMARTiSM00339. FH. 1 hit.
    [Graphical view]
    PROSITEiPS00657. FORK_HEAD_1. 1 hit.
    PS00658. FORK_HEAD_2. 1 hit.
    PS50039. FORK_HEAD_3. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q61080-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSAPDKQQPP HGGGTGGGGG AGGQAMDPAA AGPTKAKKTN AGVRRPEKPP    50
    YSYIALIVMA IQSSPSKRLT LSEIYQFLQA RFPFFRGAYQ GWKNSVRHNL 100
    SLNECFIKLP KGLGRPGKGH YWTIDPASEF MFEEGSFRRR PRGFRRKCQA 150
    LKPVYSMVNG LGFNHLPDTY GFQGSGGLSC APNSLALEGG LGMMNGHLAG 200
    NVDGMALPSH SVPHLPSNGG HSYMGGCGGS AAGEYPHHDS SVPASPLLPA 250
    GAGGVMEPHA VYSSSAAAWP PAASAALNSG ASYIKQQPLS PCNPAANPLS 300
    GSISTHSLEQ PYLHQNSHNG PAELQGIPRY HSQSPSMCDR KEFVFSFNAM 350
    ASSSMHTTGG GSYYHQQVTY QDIKPCVM 378
    Length:378
    Mass (Da):39,958
    Last modified:May 26, 2009 - v2
    Checksum:i180B6CF40D5FC858
    GO

    Sequence cautioni

    The sequence AAI38806.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.
    The sequence AAI38807.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.
    The sequence AAK35051.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti32 – 4413GPTKA…NAGVR → PHQGQEDQRRRA in AAA64885. (PubMed:11313147)CuratedAdd
    BLAST
    Sequence conflicti232 – 27241AGEYP…AWPPA → GRGVPAPRQLGARFTAARPA PAESWSRTPFTPALQQPGRP in AAA64885. (PubMed:11313147)CuratedAdd
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L35949 Genomic DNA. Translation: AAA64885.1.
    AF346834 Genomic DNA. Translation: AAK35051.1. Different initiation.
    BC138805 mRNA. Translation: AAI38806.1. Different initiation.
    BC138806 mRNA. Translation: AAI38807.1. Different initiation.
    U42556 Genomic DNA. Translation: AAC52445.1.
    CCDSiCCDS22722.2.
    PIRiI49735.
    RefSeqiNP_034556.2. NM_010426.2.
    UniGeneiMm.33897.

    Genome annotation databases

    EnsembliENSMUST00000050684; ENSMUSP00000057481; ENSMUSG00000042812.
    ENSMUST00000181504; ENSMUSP00000137662; ENSMUSG00000042812.
    GeneIDi15227.
    KEGGimmu:15227.
    UCSCiuc009nrn.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L35949 Genomic DNA. Translation: AAA64885.1 .
    AF346834 Genomic DNA. Translation: AAK35051.1 . Different initiation.
    BC138805 mRNA. Translation: AAI38806.1 . Different initiation.
    BC138806 mRNA. Translation: AAI38807.1 . Different initiation.
    U42556 Genomic DNA. Translation: AAC52445.1 .
    CCDSi CCDS22722.2.
    PIRi I49735.
    RefSeqi NP_034556.2. NM_010426.2.
    UniGenei Mm.33897.

    3D structure databases

    ProteinModelPortali Q61080.
    SMRi Q61080. Positions 48-137.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 10090.ENSMUSP00000057481.

    PTM databases

    PhosphoSitei Q61080.

    Proteomic databases

    PRIDEi Q61080.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000050684 ; ENSMUSP00000057481 ; ENSMUSG00000042812 .
    ENSMUST00000181504 ; ENSMUSP00000137662 ; ENSMUSG00000042812 .
    GeneIDi 15227.
    KEGGi mmu:15227.
    UCSCi uc009nrn.1. mouse.

    Organism-specific databases

    CTDi 2294.
    MGIi MGI:1347470. Foxf1.

    Phylogenomic databases

    eggNOGi COG5025.
    GeneTreei ENSGT00750000117270.
    HOGENOMi HOG000060124.
    HOVERGENi HBG051644.
    InParanoidi B2RSC1.
    KOi K09399.
    OMAi MTAEVQQ.
    OrthoDBi EOG7D59PX.
    PhylomeDBi Q61080.
    TreeFami TF351598.

    Miscellaneous databases

    NextBioi 287815.
    PROi Q61080.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q61080.
    CleanExi MM_FOXF1A.
    Genevestigatori Q61080.

    Family and domain databases

    Gene3Di 1.10.10.10. 1 hit.
    InterProi IPR001766. TF_fork_head.
    IPR018122. TF_fork_head_CS.
    IPR011991. WHTH_DNA-bd_dom.
    [Graphical view ]
    Pfami PF00250. Fork_head. 1 hit.
    [Graphical view ]
    PRINTSi PR00053. FORKHEAD.
    SMARTi SM00339. FH. 1 hit.
    [Graphical view ]
    PROSITEi PS00657. FORK_HEAD_1. 1 hit.
    PS00658. FORK_HEAD_2. 1 hit.
    PS50039. FORK_HEAD_3. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Members of the HNF-3/forkhead family of transcription factors exhibit distinct cellular expression patterns in lung and regulate the surfactant protein B promoter."
      Clevidence D.E., Overdier D.G., Peterson R.S., Porcella A., Ye H., Paulson K.E., Costa R.H.
      Dev. Biol. 166:195-209(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], TISSUE SPECIFICITY.
      Strain: BALB/c.
      Tissue: Lung.
    2. "Structural characterization of the mouse Foxf1a gene."
      Chang V.W.H., Ho Y.S.
      Gene 267:201-211(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], TISSUE SPECIFICITY.
      Strain: 129/Sv.
      Tissue: Lung.
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Lung.
    4. "Differential activation of lung-specific genes by two forkhead proteins, FREAC-1 and FREAC-2."
      Hellqvist M., Mahlapuu M., Samuelsson L., Enerbaeck S., Carlsson P.
      J. Biol. Chem. 271:4482-4490(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 26-378.
      Strain: 129.

    Entry informationi

    Entry nameiFOXF1_MOUSE
    AccessioniPrimary (citable) accession number: Q61080
    Secondary accession number(s): B2RSC1, Q61661
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1997
    Last sequence update: May 26, 2009
    Last modified: October 1, 2014
    This is version 117 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Caution

    It is uncertain whether Met-1 or Met-26 is the initiator.Curated

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3