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Protein

Forkhead box protein F1

Gene

Foxf1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Probable transcription activator for a number of lung-specific genes.By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi47 – 13892Fork-headPROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

  1. DNA binding Source: MGI
  2. RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity Source: GO_Central
  3. RNA polymerase II regulatory region sequence-specific DNA binding Source: MGI
  4. RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription Source: MGI
  5. transcription regulatory region DNA binding Source: MGI

GO - Biological processi

  1. blood vessel development Source: MGI
  2. branching involved in open tracheal system development Source: MGI
  3. cardiac left ventricle morphogenesis Source: MGI
  4. cellular response to cytokine stimulus Source: MGI
  5. cellular response to organic cyclic compound Source: MGI
  6. detection of wounding Source: MGI
  7. determination of left/right symmetry Source: MGI
  8. digestive tract development Source: MGI
  9. ductus arteriosus closure Source: MGI
  10. embryonic digestive tract development Source: MGI
  11. embryonic digestive tract morphogenesis Source: MGI
  12. embryonic ectodermal digestive tract morphogenesis Source: MGI
  13. embryonic foregut morphogenesis Source: MGI
  14. endocardial cushion development Source: MGI
  15. epithelial cell differentiation involved in mammary gland alveolus development Source: MGI
  16. epithelial tube branching involved in lung morphogenesis Source: MGI
  17. establishment of epithelial cell apical/basal polarity Source: MGI
  18. extracellular matrix organization Source: MGI
  19. heart development Source: MGI
  20. in utero embryonic development Source: MGI
  21. lateral mesodermal cell differentiation Source: MGI
  22. lung alveolus development Source: MGI
  23. lung development Source: MGI
  24. lung lobe morphogenesis Source: MGI
  25. lung morphogenesis Source: MGI
  26. lung vasculature development Source: MGI
  27. mesenchyme migration Source: MGI
  28. mesoderm development Source: MGI
  29. midgut development Source: MGI
  30. morphogenesis of a branching structure Source: MGI
  31. negative regulation of inflammatory response Source: MGI
  32. negative regulation of mast cell degranulation Source: MGI
  33. negative regulation of transcription from RNA polymerase II promoter Source: MGI
  34. organ morphogenesis Source: MGI
  35. pancreas development Source: MGI
  36. positive regulation of cell migration Source: MGI
  37. positive regulation of cell-substrate adhesion Source: MGI
  38. positive regulation of mesenchymal cell proliferation Source: MGI
  39. positive regulation of transcription, DNA-templated Source: MGI
  40. positive regulation of transcription from RNA polymerase II promoter Source: MGI
  41. regulation of smooth muscle cell differentiation Source: MGI
  42. renal system development Source: MGI
  43. respiratory tube development Source: MGI
  44. right lung morphogenesis Source: MGI
  45. single organismal cell-cell adhesion Source: MGI
  46. smoothened signaling pathway Source: MGI
  47. smooth muscle cell differentiation Source: MGI
  48. somitogenesis Source: MGI
  49. trachea development Source: MGI
  50. transcription from RNA polymerase II promoter Source: GOC
  51. ureter development Source: MGI
  52. vasculogenesis Source: MGI
  53. venous blood vessel development Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

Activator

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Forkhead box protein F1
Alternative name(s):
Forkhead-related protein FKHL5
Forkhead-related transcription factor 1
Short name:
FREAC-1
Hepatocyte nuclear factor 3 forkhead homolog 8
Short name:
HFH-8
Gene namesi
Name:Foxf1
Synonyms:Fkhl5, Foxf1a, Freac1, Hfh8
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 8

Organism-specific databases

MGIiMGI:1347470. Foxf1.

Subcellular locationi

Nucleus PROSITE-ProRule annotation

GO - Cellular componenti

  1. nucleus Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 378378Forkhead box protein F1PRO_0000091833Add
BLAST

Proteomic databases

PRIDEiQ61080.

PTM databases

PhosphoSiteiQ61080.

Expressioni

Tissue specificityi

Expressed primarily in lung in alveolar type II pneumocyte cells, and to a lesser extent in placenta, stomach, intestine and colon.2 Publications

Gene expression databases

BgeeiQ61080.
CleanExiMM_FOXF1A.
GenevestigatoriQ61080.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000057481.

Structurei

3D structure databases

ProteinModelPortaliQ61080.
SMRiQ61080. Positions 48-137.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domaini

Activation domains C-terminal of (and distinct from) the forkhead domains are necessary for transcriptional activation.By similarity

Sequence similaritiesi

Contains 1 fork-head DNA-binding domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiCOG5025.
GeneTreeiENSGT00780000121868.
HOGENOMiHOG000060124.
HOVERGENiHBG051644.
InParanoidiQ61080.
KOiK09399.
OMAiMTAEVQQ.
OrthoDBiEOG7D59PX.
PhylomeDBiQ61080.
TreeFamiTF351598.

Family and domain databases

Gene3Di1.10.10.10. 1 hit.
InterProiIPR001766. TF_fork_head.
IPR018122. TF_fork_head_CS.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PfamiPF00250. Fork_head. 1 hit.
[Graphical view]
PRINTSiPR00053. FORKHEAD.
SMARTiSM00339. FH. 1 hit.
[Graphical view]
PROSITEiPS00657. FORK_HEAD_1. 1 hit.
PS00658. FORK_HEAD_2. 1 hit.
PS50039. FORK_HEAD_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q61080-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSAPDKQQPP HGGGTGGGGG AGGQAMDPAA AGPTKAKKTN AGVRRPEKPP
60 70 80 90 100
YSYIALIVMA IQSSPSKRLT LSEIYQFLQA RFPFFRGAYQ GWKNSVRHNL
110 120 130 140 150
SLNECFIKLP KGLGRPGKGH YWTIDPASEF MFEEGSFRRR PRGFRRKCQA
160 170 180 190 200
LKPVYSMVNG LGFNHLPDTY GFQGSGGLSC APNSLALEGG LGMMNGHLAG
210 220 230 240 250
NVDGMALPSH SVPHLPSNGG HSYMGGCGGS AAGEYPHHDS SVPASPLLPA
260 270 280 290 300
GAGGVMEPHA VYSSSAAAWP PAASAALNSG ASYIKQQPLS PCNPAANPLS
310 320 330 340 350
GSISTHSLEQ PYLHQNSHNG PAELQGIPRY HSQSPSMCDR KEFVFSFNAM
360 370
ASSSMHTTGG GSYYHQQVTY QDIKPCVM
Length:378
Mass (Da):39,958
Last modified:May 26, 2009 - v2
Checksum:i180B6CF40D5FC858
GO

Sequence cautioni

The sequence AAI38806.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence AAI38807.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence AAK35051.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti32 – 4413GPTKA…NAGVR → PHQGQEDQRRRA in AAA64885. (PubMed:11313147)CuratedAdd
BLAST
Sequence conflicti232 – 27241AGEYP…AWPPA → GRGVPAPRQLGARFTAARPA PAESWSRTPFTPALQQPGRP in AAA64885. (PubMed:11313147)CuratedAdd
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L35949 Genomic DNA. Translation: AAA64885.1.
AF346834 Genomic DNA. Translation: AAK35051.1. Different initiation.
BC138805 mRNA. Translation: AAI38806.1. Different initiation.
BC138806 mRNA. Translation: AAI38807.1. Different initiation.
U42556 Genomic DNA. Translation: AAC52445.1.
CCDSiCCDS22722.2.
PIRiI49735.
RefSeqiNP_034556.2. NM_010426.2.
UniGeneiMm.33897.

Genome annotation databases

EnsembliENSMUST00000181504; ENSMUSP00000137662; ENSMUSG00000042812.
GeneIDi15227.
KEGGimmu:15227.
UCSCiuc009nrn.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L35949 Genomic DNA. Translation: AAA64885.1.
AF346834 Genomic DNA. Translation: AAK35051.1. Different initiation.
BC138805 mRNA. Translation: AAI38806.1. Different initiation.
BC138806 mRNA. Translation: AAI38807.1. Different initiation.
U42556 Genomic DNA. Translation: AAC52445.1.
CCDSiCCDS22722.2.
PIRiI49735.
RefSeqiNP_034556.2. NM_010426.2.
UniGeneiMm.33897.

3D structure databases

ProteinModelPortaliQ61080.
SMRiQ61080. Positions 48-137.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000057481.

PTM databases

PhosphoSiteiQ61080.

Proteomic databases

PRIDEiQ61080.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000181504; ENSMUSP00000137662; ENSMUSG00000042812.
GeneIDi15227.
KEGGimmu:15227.
UCSCiuc009nrn.1. mouse.

Organism-specific databases

CTDi2294.
MGIiMGI:1347470. Foxf1.

Phylogenomic databases

eggNOGiCOG5025.
GeneTreeiENSGT00780000121868.
HOGENOMiHOG000060124.
HOVERGENiHBG051644.
InParanoidiQ61080.
KOiK09399.
OMAiMTAEVQQ.
OrthoDBiEOG7D59PX.
PhylomeDBiQ61080.
TreeFamiTF351598.

Miscellaneous databases

NextBioi287815.
PROiQ61080.
SOURCEiSearch...

Gene expression databases

BgeeiQ61080.
CleanExiMM_FOXF1A.
GenevestigatoriQ61080.

Family and domain databases

Gene3Di1.10.10.10. 1 hit.
InterProiIPR001766. TF_fork_head.
IPR018122. TF_fork_head_CS.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PfamiPF00250. Fork_head. 1 hit.
[Graphical view]
PRINTSiPR00053. FORKHEAD.
SMARTiSM00339. FH. 1 hit.
[Graphical view]
PROSITEiPS00657. FORK_HEAD_1. 1 hit.
PS00658. FORK_HEAD_2. 1 hit.
PS50039. FORK_HEAD_3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Members of the HNF-3/forkhead family of transcription factors exhibit distinct cellular expression patterns in lung and regulate the surfactant protein B promoter."
    Clevidence D.E., Overdier D.G., Peterson R.S., Porcella A., Ye H., Paulson K.E., Costa R.H.
    Dev. Biol. 166:195-209(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], TISSUE SPECIFICITY.
    Strain: BALB/c.
    Tissue: Lung.
  2. "Structural characterization of the mouse Foxf1a gene."
    Chang V.W.H., Ho Y.S.
    Gene 267:201-211(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], TISSUE SPECIFICITY.
    Strain: 129/Sv.
    Tissue: Lung.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Lung.
  4. "Differential activation of lung-specific genes by two forkhead proteins, FREAC-1 and FREAC-2."
    Hellqvist M., Mahlapuu M., Samuelsson L., Enerbaeck S., Carlsson P.
    J. Biol. Chem. 271:4482-4490(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 26-378.
    Strain: 129.

Entry informationi

Entry nameiFOXF1_MOUSE
AccessioniPrimary (citable) accession number: Q61080
Secondary accession number(s): B2RSC1, Q61661
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: May 26, 2009
Last modified: February 4, 2015
This is version 120 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Caution

It is uncertain whether Met-1 or Met-26 is the initiator.Curated

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.