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Q61080 (FOXF1_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 115. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Forkhead box protein F1
Alternative name(s):
Forkhead-related protein FKHL5
Forkhead-related transcription factor 1
Short name=FREAC-1
Hepatocyte nuclear factor 3 forkhead homolog 8
Short name=HFH-8
Gene names
Name:Foxf1
Synonyms:Fkhl5, Foxf1a, Freac1, Hfh8
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length378 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Probable transcription activator for a number of lung-specific genes By similarity.

Subcellular location

Nucleus By similarity.

Tissue specificity

Expressed primarily in lung in alveolar type II pneumocyte cells, and to a lesser extent in placenta, stomach, intestine and colon. Ref.1 Ref.2

Domain

Activation domains C-terminal of (and distinct from) the forkhead domains are necessary for transcriptional activation By similarity.

Sequence similarities

Contains 1 fork-head DNA-binding domain.

Caution

It is uncertain whether Met-1 or Met-26 is the initiator.

Sequence caution

The sequence AAI38806.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.

The sequence AAI38807.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.

The sequence AAK35051.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.

Ontologies

Keywords
   Biological processTranscription
Transcription regulation
   Cellular componentNucleus
   LigandDNA-binding
   Molecular functionActivator
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processbranching involved in open tracheal system development

Inferred from electronic annotation. Source: Ensembl

cardiac left ventricle morphogenesis

Inferred from electronic annotation. Source: Ensembl

cell-cell adhesion

Inferred from mutant phenotype PubMed 11124112. Source: MGI

cellular response to cytokine stimulus

Inferred from direct assay PubMed 9486531. Source: MGI

cellular response to organic cyclic compound

Inferred from mutant phenotype PubMed 18421012. Source: MGI

detection of wounding

Inferred from mutant phenotype PubMed 12500195. Source: MGI

determination of left/right symmetry

Inferred from mutant phenotype PubMed 11493558. Source: MGI

ductus arteriosus closure

Inferred from electronic annotation. Source: Ensembl

embryonic digestive tract development

Inferred from genetic interaction PubMed 16439479. Source: MGI

embryonic ectodermal digestive tract morphogenesis

Inferred from electronic annotation. Source: Ensembl

embryonic foregut morphogenesis

Inferred from mutant phenotype PubMed 11493558. Source: MGI

endocardial cushion development

Inferred from electronic annotation. Source: Ensembl

epithelial cell differentiation involved in mammary gland alveolus development

Inferred from genetic interaction PubMed 16691571. Source: MGI

epithelial tube branching involved in lung morphogenesis

Inferred from mutant phenotype PubMed 11493558. Source: MGI

establishment of epithelial cell apical/basal polarity

Inferred from genetic interaction PubMed 16439479. Source: MGI

extracellular matrix organization

Inferred from genetic interaction PubMed 16439479. Source: MGI

in utero embryonic development

Inferred from mutant phenotype PubMed 11124112PubMed 11493558. Source: MGI

lateral mesodermal cell differentiation

Inferred from mutant phenotype PubMed 11124112. Source: MGI

lung alveolus development

Inferred from mutant phenotype PubMed 11493558. Source: MGI

lung development

Inferred from mutant phenotype PubMed 11437453PubMed 11493558. Source: MGI

lung lobe morphogenesis

Inferred from mutant phenotype PubMed 11493558. Source: MGI

lung morphogenesis

Inferred from mutant phenotype PubMed 11493558. Source: MGI

lung vasculature development

Inferred from electronic annotation. Source: Ensembl

mesenchyme migration

Inferred from mutant phenotype PubMed 17261592. Source: MGI

mesoderm development

Inferred from mutant phenotype PubMed 11493558. Source: MGI

midgut development

Inferred from electronic annotation. Source: Ensembl

negative regulation of inflammatory response

Inferred from mutant phenotype PubMed 18421012. Source: MGI

negative regulation of mast cell degranulation

Inferred from mutant phenotype PubMed 18421012. Source: MGI

negative regulation of transcription from RNA polymerase II promoter

Inferred from mutant phenotype PubMed 11124112PubMed 18421012. Source: MGI

organ morphogenesis

Inferred from mutant phenotype PubMed 11809759. Source: MGI

pancreas development

Inferred from electronic annotation. Source: Ensembl

positive regulation of cell migration

Inferred from mutant phenotype PubMed 17261592. Source: MGI

positive regulation of cell-substrate adhesion

Inferred from mutant phenotype PubMed 17261592. Source: MGI

positive regulation of mesenchymal cell proliferation

Inferred from mutant phenotype PubMed 11124112. Source: MGI

positive regulation of transcription from RNA polymerase II promoter

Inferred from direct assay PubMed 17261592Ref.1PubMed 9486531. Source: MGI

regulation of sequence-specific DNA binding transcription factor activity

Inferred from Biological aspect of Ancestor. Source: RefGenome

regulation of smooth muscle cell differentiation

Inferred from mutant phenotype PubMed 17881493. Source: MGI

right lung morphogenesis

Inferred from mutant phenotype PubMed 11493558. Source: MGI

smooth muscle cell differentiation

Inferred from mutant phenotype PubMed 11493558. Source: MGI

smoothened signaling pathway

Inferred from direct assay PubMed 11493558. Source: MGI

somitogenesis

Inferred from mutant phenotype PubMed 11124112. Source: MGI

trachea development

Inferred from mutant phenotype PubMed 11493558. Source: MGI

transcription from RNA polymerase II promoter

Inferred from Biological aspect of Ancestor. Source: GOC

ureter development

Inferred from electronic annotation. Source: Ensembl

vasculogenesis

Inferred from mutant phenotype PubMed 11124112PubMed 11437453PubMed 17881493. Source: MGI

venous blood vessel development

Inferred from electronic annotation. Source: Ensembl

   Cellular_componentnucleus

Inferred from direct assay PubMed 17261592. Source: MGI

transcription factor complex

Inferred from Biological aspect of Ancestor. Source: RefGenome

   Molecular_functionDNA binding

Inferred from direct assay PubMed 15987774. Source: MGI

DNA binding, bending

Inferred from Biological aspect of Ancestor. Source: RefGenome

RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity

Inferred from Biological aspect of Ancestor. Source: RefGenome

double-stranded DNA binding

Inferred from Biological aspect of Ancestor. Source: RefGenome

sequence-specific DNA binding

Inferred from electronic annotation. Source: InterPro

transcription factor binding

Inferred from Biological aspect of Ancestor. Source: RefGenome

transcription regulatory region DNA binding

Inferred from direct assay PubMed 17261592Ref.1. Source: MGI

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 378378Forkhead box protein F1
PRO_0000091833

Regions

DNA binding47 – 13892Fork-head

Experimental info

Sequence conflict32 – 4413GPTKA…NAGVR → PHQGQEDQRRRA in AAA64885. Ref.2
Sequence conflict232 – 27241AGEYP…AWPPA → GRGVPAPRQLGARFTAARPA PAESWSRTPFTPALQQPGRP in AAA64885. Ref.2

Sequences

Sequence LengthMass (Da)Tools
Q61080 [UniParc].

Last modified May 26, 2009. Version 2.
Checksum: 180B6CF40D5FC858

FASTA37839,958
        10         20         30         40         50         60 
MSAPDKQQPP HGGGTGGGGG AGGQAMDPAA AGPTKAKKTN AGVRRPEKPP YSYIALIVMA 

        70         80         90        100        110        120 
IQSSPSKRLT LSEIYQFLQA RFPFFRGAYQ GWKNSVRHNL SLNECFIKLP KGLGRPGKGH 

       130        140        150        160        170        180 
YWTIDPASEF MFEEGSFRRR PRGFRRKCQA LKPVYSMVNG LGFNHLPDTY GFQGSGGLSC 

       190        200        210        220        230        240 
APNSLALEGG LGMMNGHLAG NVDGMALPSH SVPHLPSNGG HSYMGGCGGS AAGEYPHHDS 

       250        260        270        280        290        300 
SVPASPLLPA GAGGVMEPHA VYSSSAAAWP PAASAALNSG ASYIKQQPLS PCNPAANPLS 

       310        320        330        340        350        360 
GSISTHSLEQ PYLHQNSHNG PAELQGIPRY HSQSPSMCDR KEFVFSFNAM ASSSMHTTGG 

       370 
GSYYHQQVTY QDIKPCVM 

« Hide

References

« Hide 'large scale' references
[1]"Members of the HNF-3/forkhead family of transcription factors exhibit distinct cellular expression patterns in lung and regulate the surfactant protein B promoter."
Clevidence D.E., Overdier D.G., Peterson R.S., Porcella A., Ye H., Paulson K.E., Costa R.H.
Dev. Biol. 166:195-209(1994) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], TISSUE SPECIFICITY.
Strain: BALB/c.
Tissue: Lung.
[2]"Structural characterization of the mouse Foxf1a gene."
Chang V.W.H., Ho Y.S.
Gene 267:201-211(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], TISSUE SPECIFICITY.
Strain: 129/Sv.
Tissue: Lung.
[3]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Lung.
[4]"Differential activation of lung-specific genes by two forkhead proteins, FREAC-1 and FREAC-2."
Hellqvist M., Mahlapuu M., Samuelsson L., Enerbaeck S., Carlsson P.
J. Biol. Chem. 271:4482-4490(1996) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 26-378.
Strain: 129.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
L35949 Genomic DNA. Translation: AAA64885.1.
AF346834 Genomic DNA. Translation: AAK35051.1. Different initiation.
BC138805 mRNA. Translation: AAI38806.1. Different initiation.
BC138806 mRNA. Translation: AAI38807.1. Different initiation.
U42556 Genomic DNA. Translation: AAC52445.1.
PIRI49735.
RefSeqNP_034556.2. NM_010426.2.
UniGeneMm.33897.

3D structure databases

ProteinModelPortalQ61080.
SMRQ61080. Positions 48-137.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING10090.ENSMUSP00000057481.

PTM databases

PhosphoSiteQ61080.

Proteomic databases

PRIDEQ61080.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000050684; ENSMUSP00000057481; ENSMUSG00000042812.
ENSMUST00000181504; ENSMUSP00000137662; ENSMUSG00000042812.
GeneID15227.
KEGGmmu:15227.
UCSCuc009nrn.1. mouse.

Organism-specific databases

CTD2294.
MGIMGI:1347470. Foxf1.

Phylogenomic databases

eggNOGCOG5025.
GeneTreeENSGT00750000117270.
HOGENOMHOG000060124.
HOVERGENHBG051644.
InParanoidB2RSC1.
KOK09399.
OMAMTAEVQQ.
OrthoDBEOG7D59PX.
PhylomeDBQ61080.
TreeFamTF351598.

Gene expression databases

BgeeQ61080.
CleanExMM_FOXF1A.
GenevestigatorQ61080.

Family and domain databases

Gene3D1.10.10.10. 1 hit.
InterProIPR001766. TF_fork_head.
IPR018122. TF_fork_head_CS.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PfamPF00250. Fork_head. 1 hit.
[Graphical view]
PRINTSPR00053. FORKHEAD.
SMARTSM00339. FH. 1 hit.
[Graphical view]
PROSITEPS00657. FORK_HEAD_1. 1 hit.
PS00658. FORK_HEAD_2. 1 hit.
PS50039. FORK_HEAD_3. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio287815.
PROQ61080.
SOURCESearch...

Entry information

Entry nameFOXF1_MOUSE
AccessionPrimary (citable) accession number: Q61080
Secondary accession number(s): B2RSC1, Q61661
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: May 26, 2009
Last modified: April 16, 2014
This is version 115 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot