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Q61080

- FOXF1_MOUSE

UniProt

Q61080 - FOXF1_MOUSE

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Protein
Forkhead box protein F1
Gene
Foxf1, Fkhl5, Foxf1a, Freac1, Hfh8
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at transcript leveli

Functioni

Probable transcription activator for a number of lung-specific genes By similarity.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi47 – 13892Fork-head
Add
BLAST

GO - Molecular functioni

  1. DNA binding Source: MGI
  2. DNA binding, bending Source: RefGenome
  3. RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity Source: RefGenome
  4. double-stranded DNA binding Source: RefGenome
  5. sequence-specific DNA binding Source: InterPro
  6. transcription factor binding Source: RefGenome
  7. transcription regulatory region DNA binding Source: MGI

GO - Biological processi

  1. branching involved in open tracheal system development Source: Ensembl
  2. cardiac left ventricle morphogenesis Source: Ensembl
  3. cellular response to cytokine stimulus Source: MGI
  4. cellular response to organic cyclic compound Source: MGI
  5. detection of wounding Source: MGI
  6. determination of left/right symmetry Source: MGI
  7. ductus arteriosus closure Source: Ensembl
  8. embryonic digestive tract development Source: MGI
  9. embryonic ectodermal digestive tract morphogenesis Source: Ensembl
  10. embryonic foregut morphogenesis Source: MGI
  11. endocardial cushion development Source: Ensembl
  12. epithelial cell differentiation involved in mammary gland alveolus development Source: MGI
  13. epithelial tube branching involved in lung morphogenesis Source: MGI
  14. establishment of epithelial cell apical/basal polarity Source: MGI
  15. extracellular matrix organization Source: MGI
  16. in utero embryonic development Source: MGI
  17. lateral mesodermal cell differentiation Source: MGI
  18. lung alveolus development Source: MGI
  19. lung development Source: MGI
  20. lung lobe morphogenesis Source: MGI
  21. lung morphogenesis Source: MGI
  22. lung vasculature development Source: Ensembl
  23. mesenchyme migration Source: MGI
  24. mesoderm development Source: MGI
  25. midgut development Source: Ensembl
  26. negative regulation of inflammatory response Source: MGI
  27. negative regulation of mast cell degranulation Source: MGI
  28. negative regulation of transcription from RNA polymerase II promoter Source: MGI
  29. organ morphogenesis Source: MGI
  30. pancreas development Source: Ensembl
  31. positive regulation of cell migration Source: MGI
  32. positive regulation of cell-substrate adhesion Source: MGI
  33. positive regulation of mesenchymal cell proliferation Source: MGI
  34. positive regulation of transcription from RNA polymerase II promoter Source: MGI
  35. regulation of sequence-specific DNA binding transcription factor activity Source: RefGenome
  36. regulation of smooth muscle cell differentiation Source: MGI
  37. right lung morphogenesis Source: MGI
  38. single organismal cell-cell adhesion Source: MGI
  39. smooth muscle cell differentiation Source: MGI
  40. smoothened signaling pathway Source: MGI
  41. somitogenesis Source: MGI
  42. trachea development Source: MGI
  43. transcription from RNA polymerase II promoter Source: GOC
  44. ureter development Source: Ensembl
  45. vasculogenesis Source: MGI
  46. venous blood vessel development Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

Activator

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Forkhead box protein F1
Alternative name(s):
Forkhead-related protein FKHL5
Forkhead-related transcription factor 1
Short name:
FREAC-1
Hepatocyte nuclear factor 3 forkhead homolog 8
Short name:
HFH-8
Gene namesi
Name:Foxf1
Synonyms:Fkhl5, Foxf1a, Freac1, Hfh8
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 8

Organism-specific databases

MGIiMGI:1347470. Foxf1.

Subcellular locationi

Nucleus By similarity

GO - Cellular componenti

  1. nucleus Source: MGI
  2. transcription factor complex Source: RefGenome
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 378378Forkhead box protein F1
PRO_0000091833Add
BLAST

Proteomic databases

PRIDEiQ61080.

PTM databases

PhosphoSiteiQ61080.

Expressioni

Tissue specificityi

Expressed primarily in lung in alveolar type II pneumocyte cells, and to a lesser extent in placenta, stomach, intestine and colon.2 Publications

Gene expression databases

BgeeiQ61080.
CleanExiMM_FOXF1A.
GenevestigatoriQ61080.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000057481.

Structurei

3D structure databases

ProteinModelPortaliQ61080.
SMRiQ61080. Positions 48-137.

Family & Domainsi

Domaini

Activation domains C-terminal of (and distinct from) the forkhead domains are necessary for transcriptional activation By similarity.

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG5025.
GeneTreeiENSGT00750000117270.
HOGENOMiHOG000060124.
HOVERGENiHBG051644.
InParanoidiB2RSC1.
KOiK09399.
OMAiMTAEVQQ.
OrthoDBiEOG7D59PX.
PhylomeDBiQ61080.
TreeFamiTF351598.

Family and domain databases

Gene3Di1.10.10.10. 1 hit.
InterProiIPR001766. TF_fork_head.
IPR018122. TF_fork_head_CS.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PfamiPF00250. Fork_head. 1 hit.
[Graphical view]
PRINTSiPR00053. FORKHEAD.
SMARTiSM00339. FH. 1 hit.
[Graphical view]
PROSITEiPS00657. FORK_HEAD_1. 1 hit.
PS00658. FORK_HEAD_2. 1 hit.
PS50039. FORK_HEAD_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q61080-1 [UniParc]FASTAAdd to Basket

« Hide

MSAPDKQQPP HGGGTGGGGG AGGQAMDPAA AGPTKAKKTN AGVRRPEKPP    50
YSYIALIVMA IQSSPSKRLT LSEIYQFLQA RFPFFRGAYQ GWKNSVRHNL 100
SLNECFIKLP KGLGRPGKGH YWTIDPASEF MFEEGSFRRR PRGFRRKCQA 150
LKPVYSMVNG LGFNHLPDTY GFQGSGGLSC APNSLALEGG LGMMNGHLAG 200
NVDGMALPSH SVPHLPSNGG HSYMGGCGGS AAGEYPHHDS SVPASPLLPA 250
GAGGVMEPHA VYSSSAAAWP PAASAALNSG ASYIKQQPLS PCNPAANPLS 300
GSISTHSLEQ PYLHQNSHNG PAELQGIPRY HSQSPSMCDR KEFVFSFNAM 350
ASSSMHTTGG GSYYHQQVTY QDIKPCVM 378
Length:378
Mass (Da):39,958
Last modified:May 26, 2009 - v2
Checksum:i180B6CF40D5FC858
GO

Sequence cautioni

The sequence AAI38806.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.
The sequence AAI38807.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.
The sequence AAK35051.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti32 – 4413GPTKA…NAGVR → PHQGQEDQRRRA in AAA64885. 1 Publication
Add
BLAST
Sequence conflicti232 – 27241AGEYP…AWPPA → GRGVPAPRQLGARFTAARPA PAESWSRTPFTPALQQPGRP in AAA64885. 1 Publication
Add
BLAST

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L35949 Genomic DNA. Translation: AAA64885.1.
AF346834 Genomic DNA. Translation: AAK35051.1. Different initiation.
BC138805 mRNA. Translation: AAI38806.1. Different initiation.
BC138806 mRNA. Translation: AAI38807.1. Different initiation.
U42556 Genomic DNA. Translation: AAC52445.1.
CCDSiCCDS22722.2.
PIRiI49735.
RefSeqiNP_034556.2. NM_010426.2.
UniGeneiMm.33897.

Genome annotation databases

EnsembliENSMUST00000050684; ENSMUSP00000057481; ENSMUSG00000042812.
ENSMUST00000181504; ENSMUSP00000137662; ENSMUSG00000042812.
GeneIDi15227.
KEGGimmu:15227.
UCSCiuc009nrn.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L35949 Genomic DNA. Translation: AAA64885.1 .
AF346834 Genomic DNA. Translation: AAK35051.1 . Different initiation.
BC138805 mRNA. Translation: AAI38806.1 . Different initiation.
BC138806 mRNA. Translation: AAI38807.1 . Different initiation.
U42556 Genomic DNA. Translation: AAC52445.1 .
CCDSi CCDS22722.2.
PIRi I49735.
RefSeqi NP_034556.2. NM_010426.2.
UniGenei Mm.33897.

3D structure databases

ProteinModelPortali Q61080.
SMRi Q61080. Positions 48-137.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 10090.ENSMUSP00000057481.

PTM databases

PhosphoSitei Q61080.

Proteomic databases

PRIDEi Q61080.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000050684 ; ENSMUSP00000057481 ; ENSMUSG00000042812 .
ENSMUST00000181504 ; ENSMUSP00000137662 ; ENSMUSG00000042812 .
GeneIDi 15227.
KEGGi mmu:15227.
UCSCi uc009nrn.1. mouse.

Organism-specific databases

CTDi 2294.
MGIi MGI:1347470. Foxf1.

Phylogenomic databases

eggNOGi COG5025.
GeneTreei ENSGT00750000117270.
HOGENOMi HOG000060124.
HOVERGENi HBG051644.
InParanoidi B2RSC1.
KOi K09399.
OMAi MTAEVQQ.
OrthoDBi EOG7D59PX.
PhylomeDBi Q61080.
TreeFami TF351598.

Miscellaneous databases

NextBioi 287815.
PROi Q61080.
SOURCEi Search...

Gene expression databases

Bgeei Q61080.
CleanExi MM_FOXF1A.
Genevestigatori Q61080.

Family and domain databases

Gene3Di 1.10.10.10. 1 hit.
InterProi IPR001766. TF_fork_head.
IPR018122. TF_fork_head_CS.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view ]
Pfami PF00250. Fork_head. 1 hit.
[Graphical view ]
PRINTSi PR00053. FORKHEAD.
SMARTi SM00339. FH. 1 hit.
[Graphical view ]
PROSITEi PS00657. FORK_HEAD_1. 1 hit.
PS00658. FORK_HEAD_2. 1 hit.
PS50039. FORK_HEAD_3. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Members of the HNF-3/forkhead family of transcription factors exhibit distinct cellular expression patterns in lung and regulate the surfactant protein B promoter."
    Clevidence D.E., Overdier D.G., Peterson R.S., Porcella A., Ye H., Paulson K.E., Costa R.H.
    Dev. Biol. 166:195-209(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], TISSUE SPECIFICITY.
    Strain: BALB/c.
    Tissue: Lung.
  2. "Structural characterization of the mouse Foxf1a gene."
    Chang V.W.H., Ho Y.S.
    Gene 267:201-211(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], TISSUE SPECIFICITY.
    Strain: 129/Sv.
    Tissue: Lung.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Lung.
  4. "Differential activation of lung-specific genes by two forkhead proteins, FREAC-1 and FREAC-2."
    Hellqvist M., Mahlapuu M., Samuelsson L., Enerbaeck S., Carlsson P.
    J. Biol. Chem. 271:4482-4490(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 26-378.
    Strain: 129.

Entry informationi

Entry nameiFOXF1_MOUSE
AccessioniPrimary (citable) accession number: Q61080
Secondary accession number(s): B2RSC1, Q61661
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: May 26, 2009
Last modified: July 9, 2014
This is version 116 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Caution

It is uncertain whether Met-1 or Met-26 is the initiator.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi