Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Forkhead box protein F1

Gene

Foxf1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Probable transcription activator for a number of lung-specific genes.By similarity

Caution

It is uncertain whether Met-1 or Met-26 is the initiator.Curated

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi47 – 138Fork-headPROSITE-ProRule annotationAdd BLAST92

GO - Molecular functioni

GO - Biological processi

  • animal organ morphogenesis Source: MGI
  • blood vessel development Source: MGI
  • cardiac left ventricle morphogenesis Source: MGI
  • cell-cell adhesion Source: MGI
  • cellular response to cytokine stimulus Source: MGI
  • cellular response to organic cyclic compound Source: MGI
  • detection of wounding Source: MGI
  • determination of left/right symmetry Source: MGI
  • digestive tract development Source: MGI
  • ductus arteriosus closure Source: MGI
  • embryonic digestive tract development Source: MGI
  • embryonic digestive tract morphogenesis Source: MGI
  • embryonic ectodermal digestive tract morphogenesis Source: MGI
  • embryonic foregut morphogenesis Source: MGI
  • endocardial cushion development Source: MGI
  • epithelial cell differentiation involved in mammary gland alveolus development Source: MGI
  • epithelial tube branching involved in lung morphogenesis Source: MGI
  • establishment of epithelial cell apical/basal polarity Source: MGI
  • extracellular matrix organization Source: MGI
  • heart development Source: MGI
  • in utero embryonic development Source: MGI
  • lateral mesodermal cell differentiation Source: MGI
  • lung alveolus development Source: MGI
  • lung development Source: MGI
  • lung lobe morphogenesis Source: MGI
  • lung morphogenesis Source: MGI
  • lung vasculature development Source: MGI
  • mesenchyme migration Source: MGI
  • mesoderm development Source: MGI
  • midgut development Source: MGI
  • morphogenesis of a branching structure Source: MGI
  • negative regulation of inflammatory response Source: MGI
  • negative regulation of mast cell degranulation Source: MGI
  • negative regulation of transcription by RNA polymerase II Source: MGI
  • pancreas development Source: MGI
  • positive regulation of cell migration Source: MGI
  • positive regulation of cell-substrate adhesion Source: MGI
  • positive regulation of mesenchymal cell proliferation Source: MGI
  • positive regulation of transcription, DNA-templated Source: MGI
  • positive regulation of transcription by RNA polymerase II Source: MGI
  • regulation of smooth muscle cell differentiation Source: MGI
  • renal system development Source: MGI
  • respiratory tube development Source: MGI
  • right lung morphogenesis Source: MGI
  • smoothened signaling pathway Source: MGI
  • smooth muscle cell differentiation Source: MGI
  • somitogenesis Source: MGI
  • trachea development Source: MGI
  • ureter development Source: MGI
  • vasculogenesis Source: MGI
  • venous blood vessel development Source: MGI

Keywordsi

Molecular functionActivator, DNA-binding
Biological processTranscription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Forkhead box protein F1
Alternative name(s):
Forkhead-related protein FKHL5
Forkhead-related transcription factor 1
Short name:
FREAC-1
Hepatocyte nuclear factor 3 forkhead homolog 8
Short name:
HFH-8
Gene namesi
Name:Foxf1
Synonyms:Fkhl5, Foxf1a, Freac1, Hfh8
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 8

Organism-specific databases

MGIiMGI:1347470 Foxf1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000918331 – 378Forkhead box protein F1Add BLAST378

Proteomic databases

MaxQBiQ61080
PaxDbiQ61080
PRIDEiQ61080

PTM databases

iPTMnetiQ61080
PhosphoSitePlusiQ61080

Expressioni

Tissue specificityi

Expressed primarily in lung in alveolar type II pneumocyte cells, and to a lesser extent in placenta, stomach, intestine and colon.2 Publications

Gene expression databases

BgeeiENSMUSG00000042812
CleanExiMM_FOXF1A
GenevisibleiQ61080 MM

Interactioni

Protein-protein interaction databases

BioGridi200290, 16 interactors
STRINGi10090.ENSMUSP00000057481

Structurei

3D structure databases

ProteinModelPortaliQ61080
SMRiQ61080
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domaini

Activation domains C-terminal of (and distinct from) the forkhead domains are necessary for transcriptional activation.By similarity

Phylogenomic databases

eggNOGiKOG2294 Eukaryota
COG5025 LUCA
GeneTreeiENSGT00920000148947
HOGENOMiHOG000060124
HOVERGENiHBG051644
InParanoidiQ61080
KOiK09399
OMAiDQSYLHQ
OrthoDBiEOG091G11UK
PhylomeDBiQ61080
TreeFamiTF351598

Family and domain databases

CDDicd00059 FH, 1 hit
Gene3Di1.10.10.10, 1 hit
InterProiView protein in InterPro
IPR001766 Fork_head_dom
IPR018122 TF_fork_head_CS_1
IPR030456 TF_fork_head_CS_2
IPR036388 WH-like_DNA-bd_sf
IPR036390 WH_DNA-bd_sf
PfamiView protein in Pfam
PF00250 Forkhead, 1 hit
PRINTSiPR00053 FORKHEAD
SMARTiView protein in SMART
SM00339 FH, 1 hit
SUPFAMiSSF46785 SSF46785, 1 hit
PROSITEiView protein in PROSITE
PS00657 FORK_HEAD_1, 1 hit
PS00658 FORK_HEAD_2, 1 hit
PS50039 FORK_HEAD_3, 1 hit

Sequencei

Sequence statusi: Complete.

Q61080-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSAPDKQQPP HGGGTGGGGG AGGQAMDPAA AGPTKAKKTN AGVRRPEKPP
60 70 80 90 100
YSYIALIVMA IQSSPSKRLT LSEIYQFLQA RFPFFRGAYQ GWKNSVRHNL
110 120 130 140 150
SLNECFIKLP KGLGRPGKGH YWTIDPASEF MFEEGSFRRR PRGFRRKCQA
160 170 180 190 200
LKPVYSMVNG LGFNHLPDTY GFQGSGGLSC APNSLALEGG LGMMNGHLAG
210 220 230 240 250
NVDGMALPSH SVPHLPSNGG HSYMGGCGGS AAGEYPHHDS SVPASPLLPA
260 270 280 290 300
GAGGVMEPHA VYSSSAAAWP PAASAALNSG ASYIKQQPLS PCNPAANPLS
310 320 330 340 350
GSISTHSLEQ PYLHQNSHNG PAELQGIPRY HSQSPSMCDR KEFVFSFNAM
360 370
ASSSMHTTGG GSYYHQQVTY QDIKPCVM
Length:378
Mass (Da):39,958
Last modified:May 26, 2009 - v2
Checksum:i180B6CF40D5FC858
GO

Sequence cautioni

The sequence AAI38806 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence AAI38807 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence AAK35051 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti32 – 44GPTKA…NAGVR → PHQGQEDQRRRA in AAA64885 (PubMed:11313147).CuratedAdd BLAST13
Sequence conflicti232 – 272AGEYP…AWPPA → GRGVPAPRQLGARFTAARPA PAESWSRTPFTPALQQPGRP in AAA64885 (PubMed:11313147).CuratedAdd BLAST41

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L35949 Genomic DNA Translation: AAA64885.1
AF346834 Genomic DNA Translation: AAK35051.1 Different initiation.
BC138805 mRNA Translation: AAI38806.1 Different initiation.
BC138806 mRNA Translation: AAI38807.1 Different initiation.
U42556 Genomic DNA Translation: AAC52445.1
CCDSiCCDS22722.2
PIRiI49735
RefSeqiNP_034556.2, NM_010426.2
UniGeneiMm.33897

Genome annotation databases

EnsembliENSMUST00000181504; ENSMUSP00000137662; ENSMUSG00000042812
GeneIDi15227
KEGGimmu:15227
UCSCiuc009nrn.2 mouse

Similar proteinsi

Entry informationi

Entry nameiFOXF1_MOUSE
AccessioniPrimary (citable) accession number: Q61080
Secondary accession number(s): B2RSC1, Q61661
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: May 26, 2009
Last modified: June 20, 2018
This is version 145 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health