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Q61079

- SIM2_MOUSE

UniProt

Q61079 - SIM2_MOUSE

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Protein

Single-minded homolog 2

Gene
Sim2
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Transcription factor that may be a master gene of CNS development in cooperation with Arnt. It may have pleiotropic effects in the tissues expressed during development.

GO - Molecular functioni

  1. DNA binding Source: MGI
  2. protein binding Source: MGI
  3. protein heterodimerization activity Source: UniProtKB
  4. sequence-specific DNA binding transcription factor activity Source: InterPro
  5. signal transducer activity Source: InterPro

GO - Biological processi

  1. cell differentiation Source: UniProtKB-KW
  2. embryonic pattern specification Source: MGI
  3. lung development Source: MGI
  4. negative regulation of transcription, DNA-templated Source: MGI
  5. negative regulation of transcription from RNA polymerase II promoter Source: MGI
  6. nervous system development Source: UniProtKB-KW
  7. transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Keywords - Biological processi

Differentiation, Neurogenesis, Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Single-minded homolog 2
Alternative name(s):
SIM transcription factor
Short name:
mSIM
Gene namesi
Name:Sim2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 16

Organism-specific databases

MGIiMGI:98307. Sim2.

Subcellular locationi

Nucleus By similarity

GO - Cellular componenti

  1. nucleus Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 657657Single-minded homolog 2PRO_0000127442Add
BLAST

Proteomic databases

PRIDEiQ61079.

PTM databases

PhosphoSiteiQ61079.

Expressioni

Tissue specificityi

Transcripts were detected in high levels in kidney followed by skeletal muscle and lung. Low levels were found in testis, brain and heart. In early fetal development it is found in CNS, developing kidney, tongue epithelium and cartilage primordia.

Gene expression databases

BgeeiQ61079.
CleanExiMM_SIM2.
GenevestigatoriQ61079.

Interactioni

Subunit structurei

Efficient DNA binding requires dimerization with another bHLH protein. Heterodimer of SIM2 and ARNT.1 Publication

Protein-protein interaction databases

IntActiQ61079. 2 interactions.

Structurei

3D structure databases

ProteinModelPortaliQ61079.
SMRiQ61079. Positions 2-333.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini1 – 5353bHLHAdd
BLAST
Domaini77 – 14771PAS 1Add
BLAST
Domaini218 – 28871PACAdd
BLAST
Domaini218 – 28871PAS 2Add
BLAST
Domaini336 – 657322Single-minded C-terminalAdd
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi367 – 38620Nuclear localization signal By similarityAdd
BLAST

Sequence similaritiesi

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiNOG310284.
GeneTreeiENSGT00730000110507.
HOGENOMiHOG000236298.
HOVERGENiHBG003936.
InParanoidiQ61079.
KOiK09100.
OMAiSDLLYAP.
OrthoDBiEOG790G0R.
PhylomeDBiQ61079.
TreeFamiTF317772.

Family and domain databases

InterProiIPR011598. bHLH_dom.
IPR001610. PAC.
IPR000014. PAS.
IPR013767. PAS_fold.
IPR013655. PAS_fold_3.
IPR010578. SIM_C.
[Graphical view]
PfamiPF00989. PAS. 1 hit.
PF08447. PAS_3. 1 hit.
PF06621. SIM_C. 1 hit.
[Graphical view]
SMARTiSM00353. HLH. 1 hit.
SM00086. PAC. 1 hit.
SM00091. PAS. 2 hits.
[Graphical view]
SUPFAMiSSF47459. SSF47459. 1 hit.
SSF55785. SSF55785. 2 hits.
PROSITEiPS50888. BHLH. 1 hit.
PS50112. PAS. 2 hits.
PS51302. SIM_C. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q61079-1 [UniParc]FASTAAdd to Basket

« Hide

MKEKSKNAAK TRREKENGEF YELAKLLPLP SAITSQLDKA SIIRLTTSYL    50
KMRAVFPEGL GDAWGQPSRT GPLDSVAKEL GSHLLQTLDG FVFVVASDGK 100
IMYISETASV HLGLSQVELT GNSIYEYIHP SDHDEMTAVL TAHPPLHHHL 150
LQEYEIERSF FLRMKCVLAK RNAGLTCSGY KVIHCSGYLK IRQYMLDMSL 200
YDSCYQIVGL VAVGQSLPPS AITEIKLHSN MFMFRASLDL KLIFLDSRVT 250
ELTGYEPQDL IEKTLYHHVH GCDTFHLRYA HHLLLVKGQV TTKYYRLLSK 300
LGGWVWVQSY ATVVHNSRSS RPHCIVSVNY VLTDVEYKEL QLSLDQVSTS 350
KSQESWRTTL STSQETRKSA KPKNTKMKTK LRTNPYPPQQ YSSFQMDKLE 400
CSQVGNWRTS PPTNAVAPPE QQLHSEASDL LYGPPYSLPF SYHYGHFPLD 450
SHVFSSKKPG LPAKFGQPQG SPCEVARFFL STLPASSECQ WHCANSLVPS 500
SSSPAKNLSE PSPVNAARHG LVPNYEAPSA AARRFCEDPA PPSFPSCGHY 550
REEPALGPAK APRQASRDAA RLALARAPPE CCAPPAPEPQ APAQLPFVLL 600
NYHRVLARRG PLGSAAPGAP EAAGSLRPRH PGPVAASAPG APRPHYLGAS 650
VIITNGR 657
Length:657
Mass (Da):72,513
Last modified:November 1, 1997 - v1
Checksum:iC7904CD24C0ABBAF
GO

Sequence cautioni

The sequence AAA91202.1 differs from that shown. Reason: Frameshift at positions 382, 390, 430 and 641.

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti263 – 2631K → R in BAA09700. 1 Publication
Sequence conflicti263 – 2631K → R in AAB84099. 1 Publication
Sequence conflicti336 – 3361E → G in AAA91202. 1 Publication
Sequence conflicti501 – 5011S → T in AAA91202. 1 Publication
Sequence conflicti512 – 5121S → P in AAB84099. 1 Publication
Sequence conflicti541 – 5411P → R in AAA91202. 1 Publication
Sequence conflicti561 – 58525APRQA…CCAPP → VLARRPGRARCMWES in AAA91202. 1 PublicationAdd
BLAST
Sequence conflicti590 – 5912QA → HG in AAA91202. 1 Publication
Sequence conflicti638 – 6381A → R in BAA09700. 1 Publication
Sequence conflicti638 – 6381A → R in AAB84099. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U42554 mRNA. Translation: AAB19098.1.
D63383 mRNA. Translation: BAA09700.1.
U40576 mRNA. Translation: AAA91202.1. Frameshift.
AF023873
, AF023864, AF023865, AF023869, AF023871, AF023870, AF023868, AF023867, AF023866, AF023872 Genomic DNA. Translation: AAB84099.1.
D64135 mRNA. Translation: BAA11013.1.
CCDSiCCDS37406.1.
RefSeqiNP_035507.2. NM_011377.2.
UniGeneiMm.4775.

Genome annotation databases

EnsembliENSMUST00000072182; ENSMUSP00000072043; ENSMUSG00000062713.
GeneIDi20465.
KEGGimmu:20465.
UCSCiuc008aae.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U42554 mRNA. Translation: AAB19098.1 .
D63383 mRNA. Translation: BAA09700.1 .
U40576 mRNA. Translation: AAA91202.1 . Frameshift.
AF023873
, AF023864 , AF023865 , AF023869 , AF023871 , AF023870 , AF023868 , AF023867 , AF023866 , AF023872 Genomic DNA. Translation: AAB84099.1 .
D64135 mRNA. Translation: BAA11013.1 .
CCDSi CCDS37406.1.
RefSeqi NP_035507.2. NM_011377.2.
UniGenei Mm.4775.

3D structure databases

ProteinModelPortali Q61079.
SMRi Q61079. Positions 2-333.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

IntActi Q61079. 2 interactions.

PTM databases

PhosphoSitei Q61079.

Proteomic databases

PRIDEi Q61079.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000072182 ; ENSMUSP00000072043 ; ENSMUSG00000062713 .
GeneIDi 20465.
KEGGi mmu:20465.
UCSCi uc008aae.1. mouse.

Organism-specific databases

CTDi 6493.
MGIi MGI:98307. Sim2.

Phylogenomic databases

eggNOGi NOG310284.
GeneTreei ENSGT00730000110507.
HOGENOMi HOG000236298.
HOVERGENi HBG003936.
InParanoidi Q61079.
KOi K09100.
OMAi SDLLYAP.
OrthoDBi EOG790G0R.
PhylomeDBi Q61079.
TreeFami TF317772.

Miscellaneous databases

NextBioi 298563.
PROi Q61079.
SOURCEi Search...

Gene expression databases

Bgeei Q61079.
CleanExi MM_SIM2.
Genevestigatori Q61079.

Family and domain databases

InterProi IPR011598. bHLH_dom.
IPR001610. PAC.
IPR000014. PAS.
IPR013767. PAS_fold.
IPR013655. PAS_fold_3.
IPR010578. SIM_C.
[Graphical view ]
Pfami PF00989. PAS. 1 hit.
PF08447. PAS_3. 1 hit.
PF06621. SIM_C. 1 hit.
[Graphical view ]
SMARTi SM00353. HLH. 1 hit.
SM00086. PAC. 1 hit.
SM00091. PAS. 2 hits.
[Graphical view ]
SUPFAMi SSF47459. SSF47459. 1 hit.
SSF55785. SSF55785. 2 hits.
PROSITEi PS50888. BHLH. 1 hit.
PS50112. PAS. 2 hits.
PS51302. SIM_C. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Characterization of msim, a murine homologue of the Drosophila sim transcription factor."
    Moffett P., Dayo M., Reece M., McCormack M.K., Pelletier J.
    Genomics 35:144-155(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Fetal kidney.
  2. "cDNA cloning of a murine homologue of Drosophila single-minded, its mRNA expression in mouse development, and chromosome localization."
    Ema M., Suzuki M., Morita M., Hirose K., Sogawa K., Matsuda Y., Gotoh O., Saijoh Y., Fujii H., Hamada H., Fujii-Kuriyama Y.
    Biochem. Biophys. Res. Commun. 218:588-594(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: C57BL/6J.
  3. "Expression patterns of two murine homologs of Drosophila single-minded suggest possible roles in embryonic patterning and in the pathogenesis of Down syndrome."
    Fan C.-M., Kuwana E., Bulfone A., Fletcher C.F., Copeland N.G., Jenkins N.A., Crews S., Martinez S., Puelles L., Rubenstein J.L., Tessier-Lavigne M.
    Mol. Cell. Neurosci. 7:1-16(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA].
    Strain: 129/Sv and Swiss Webster.
    Tissue: Embryonic brain.
  4. "The mammalian single-minded (SIM) gene: mouse cDNA structure and diencephalic expression indicate a candidate gene for Down syndrome."
    Yamaki A., Noda S., Kudoh J., Shindoh N., Maeda H., Minoshima S., Kawasaki K., Shimizu Y., Shimizu N.
    Genomics 35:136-143(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: ICR X Swiss Webster.
    Tissue: Embryo.
  5. "Two murine homologs of the Drosophila single-minded protein that interact with the mouse aryl hydrocarbon receptor nuclear translocator protein."
    Probst M.R., Fan C.-M., Tessier-Lavigne M., Hankinson O.
    J. Biol. Chem. 272:4451-4457(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBUNIT.

Entry informationi

Entry nameiSIM2_MOUSE
AccessioniPrimary (citable) accession number: Q61079
Secondary accession number(s): O35391, Q61046, Q61904
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1997
Last modified: July 9, 2014
This is version 133 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi