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Q61074 (PPM1G_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 124. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Protein phosphatase 1G

EC=3.1.3.16
Alternative name(s):
Fibroblast growth factor-inducible protein 13
Short name=FIN13
Protein phosphatase 1C
Protein phosphatase 2C isoform gamma
Short name=PP2C-gamma
Protein phosphatase magnesium-dependent 1 gamma
Gene names
Name:Ppm1g
Synonyms:Fin13, Ppm1c
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length542 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

May be involved in regulation of cell cycle. Ref.1

Catalytic activity

[a protein]-serine/threonine phosphate + H2O = [a protein]-serine/threonine + phosphate.

Cofactor

Binds 2 magnesium or manganese ions per subunit By similarity.

Subcellular location

Nucleus Ref.1.

Tissue specificity

Highly expressed in testis. Low level of expression in kidney. Also expressed in a number of tissues undergoing proliferation including embryo, uterus at pregnancy, placenta, and ovaries.

Induction

By FGF-4 and serum.

Sequence similarities

Belongs to the PP2C family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 542542Protein phosphatase 1G
PRO_0000057751

Regions

Compositional bias258 – 31962Asp/Glu-rich (acidic)

Sites

Metal binding601Manganese 1 By similarity
Metal binding601Manganese 2 By similarity
Metal binding611Manganese 1; via carbonyl oxygen By similarity
Metal binding4381Manganese 2 By similarity
Metal binding4931Manganese 2 By similarity

Amino acid modifications

Modified residue3801N6-acetyllysine Ref.4
Modified residue5241Phosphoserine By similarity

Experimental info

Sequence conflict123 – 1264EDED → NSAR Ref.3

Sequences

Sequence LengthMass (Da)Tools
Q61074 [UniParc].

Last modified July 15, 1999. Version 3.
Checksum: 1DC72E7A66E71453

FASTA54258,728
        10         20         30         40         50         60 
MGAYLSQPNT VKCSGDGVGA PRLPLPYGFS AMQGWRVSME DAHNCIPELD NETAMFSVYD 

        70         80         90        100        110        120 
GHGGEEVALY CAKYLPDIIK DQKAYKEGKL QKALQDAFLA IDAKLTTEEV IKELAQIAGR 

       130        140        150        160        170        180 
PTEDEDDKDK VADEDDVDNE EAALLHEEAT MTIEELLTRY GQNCQKVPPH TKSGIGTGDE 

       190        200        210        220        230        240 
PGPQGLNGEA GPEDPSRETP SQENGPTAKG HTGFSSNSEH GTEAGQISEP GTATGEAGPS 

       250        260        270        280        290        300 
CSSASDKLPR VAKSKFFEDS EDESDEVEEE EDDSEECSED EDGYSSEEAE NEEDEDDTEE 

       310        320        330        340        350        360 
AEEDDDEEMM VPGMEGKEEP GSDSGTTAVV ALIRGKQLIV ANAGDSRCVV SEAGKALDMS 

       370        380        390        400        410        420 
YDHKPEDEVE LARIKNAGGK VTMDGRVNGG LNLSRAIGDH FYKRNKNLPP QEQMISALPD 

       430        440        450        460        470        480 
IKVLTLTDDH EFMVIACDGI WNVMSSQEVV DFIQSKISQR DENGELRLLS SIVEELLDQC 

       490        500        510        520        530        540 
LAPDTSGDGT GCDNMTCIII CFKPRNTVEL QAESGKRKLE EALSTEGAED TGNSDKKKAK 


RD 

« Hide

References

« Hide 'large scale' references
[1]"FIN13, a novel growth factor-inducible serine-threonine phosphatase which can inhibit cell cycle progression."
Guthridge M.A., Bellosta P., Tavoloni N., Basilico C.
Mol. Cell. Biol. 17:5485-5498(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, SUBCELLULAR LOCATION.
[2]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: FVB/N.
Tissue: Mammary gland.
[3]"Induction of expression of growth-related genes by FGF-4 in mouse fibroblasts."
Guthridge M.A., Seldin M., Basilico C.
Oncogene 12:1267-1278(1996) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 123-420.
[4]"SIRT5-mediated lysine desuccinylation impacts diverse metabolic pathways."
Park J., Chen Y., Tishkoff D.X., Peng C., Tan M., Dai L., Xie Z., Zhang Y., Zwaans B.M., Skinner M.E., Lombard D.B., Zhao Y.
Mol. Cell 50:919-930(2013) [PubMed] [Europe PMC] [Abstract]
Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-380, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
Tissue: Embryonic fibroblast.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
BC009004 mRNA. Translation: AAH09004.1.
U42383 mRNA. Translation: AAC26322.1.
CCDSCCDS19179.1.
RefSeqNP_032040.1. NM_008014.3.
UniGeneMm.14501.

3D structure databases

ProteinModelPortalQ61074.
SMRQ61074. Positions 1-126, 297-503.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

IntActQ61074. 2 interactions.
MINTMINT-1675839.
STRING10090.ENSMUSP00000031032.

PTM databases

PhosphoSiteQ61074.

Proteomic databases

MaxQBQ61074.
PaxDbQ61074.
PRIDEQ61074.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000031032; ENSMUSP00000031032; ENSMUSG00000029147.
GeneID14208.
KEGGmmu:14208.
UCSCuc008wxr.1. mouse.

Organism-specific databases

CTD5496.
MGIMGI:106065. Ppm1g.

Phylogenomic databases

eggNOGCOG0631.
GeneTreeENSGT00730000110861.
HOGENOMHOG000233896.
HOVERGENHBG053647.
InParanoidQ61074.
KOK17499.
OMAMISAMPD.
OrthoDBEOG7034GD.
PhylomeDBQ61074.
TreeFamTF354280.

Gene expression databases

BgeeQ61074.
GenevestigatorQ61074.

Family and domain databases

Gene3D3.60.40.10. 2 hits.
InterProIPR001932. PP2C-like_dom.
IPR000222. PP2C_Mn2_Asp60_BS.
IPR015655. Protein_Pase_2C.
[Graphical view]
PANTHERPTHR13832. PTHR13832. 1 hit.
PfamPF00481. PP2C. 2 hits.
[Graphical view]
SMARTSM00331. PP2C_SIG. 1 hit.
SM00332. PP2Cc. 1 hit.
[Graphical view]
SUPFAMSSF81606. SSF81606. 2 hits.
PROSITEPS01032. PP2C. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSPPM1G. mouse.
NextBio285454.
PROQ61074.
SOURCESearch...

Entry information

Entry namePPM1G_MOUSE
AccessionPrimary (citable) accession number: Q61074
Entry history
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: July 15, 1999
Last modified: July 9, 2014
This is version 124 of the entry and version 3 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot