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Protein

Protein phosphatase 1G

Gene

Ppm1g

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

May be involved in regulation of cell cycle.1 Publication

Catalytic activityi

[a protein]-serine/threonine phosphate + H2O = [a protein]-serine/threonine + phosphate.

Cofactori

Mg2+By similarity, Mn2+By similarityNote: Binds 2 magnesium or manganese ions per subunit.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi60 – 601Manganese 1By similarity
Metal bindingi60 – 601Manganese 2By similarity
Metal bindingi61 – 611Manganese 1; via carbonyl oxygenBy similarity
Metal bindingi438 – 4381Manganese 2By similarity
Metal bindingi493 – 4931Manganese 2By similarity

GO - Molecular functioni

  1. metal ion binding Source: UniProtKB-KW
  2. phosphoprotein phosphatase activity Source: MGI
  3. protein serine/threonine phosphatase activity Source: MGI

GO - Biological processi

  1. cell cycle arrest Source: MGI
  2. peptidyl-threonine dephosphorylation Source: MGI
  3. protein dephosphorylation Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protein phosphatase

Keywords - Biological processi

Cell cycle

Keywords - Ligandi

Magnesium, Manganese, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Protein phosphatase 1G (EC:3.1.3.16)
Alternative name(s):
Fibroblast growth factor-inducible protein 13
Short name:
FIN13
Protein phosphatase 1C
Protein phosphatase 2C isoform gamma
Short name:
PP2C-gamma
Protein phosphatase magnesium-dependent 1 gamma
Gene namesi
Name:Ppm1g
Synonyms:Fin13, Ppm1c
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 5

Organism-specific databases

MGIiMGI:106065. Ppm1g.

Subcellular locationi

Nucleus 1 Publication

GO - Cellular componenti

  1. nucleoplasm Source: MGI
  2. nucleus Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 542542Protein phosphatase 1GPRO_0000057751Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei380 – 3801N6-acetyllysine1 Publication
Modified residuei524 – 5241PhosphoserineBy similarity

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

MaxQBiQ61074.
PaxDbiQ61074.
PRIDEiQ61074.

PTM databases

PhosphoSiteiQ61074.

Expressioni

Tissue specificityi

Highly expressed in testis. Low level of expression in kidney. Also expressed in a number of tissues undergoing proliferation including embryo, uterus at pregnancy, placenta, and ovaries.

Inductioni

By FGF-4 and serum.

Gene expression databases

BgeeiQ61074.
GenevestigatoriQ61074.

Interactioni

Protein-protein interaction databases

IntActiQ61074. 2 interactions.
MINTiMINT-1675839.
STRINGi10090.ENSMUSP00000031032.

Structurei

3D structure databases

ProteinModelPortaliQ61074.
SMRiQ61074. Positions 1-126, 297-503.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi258 – 31962Asp/Glu-rich (acidic)Add
BLAST

Sequence similaritiesi

Belongs to the PP2C family.Curated

Phylogenomic databases

eggNOGiCOG0631.
GeneTreeiENSGT00770000120571.
HOGENOMiHOG000233896.
HOVERGENiHBG053647.
InParanoidiQ61074.
KOiK17499.
OMAiQEQMISA.
OrthoDBiEOG7034GD.
PhylomeDBiQ61074.
TreeFamiTF354280.

Family and domain databases

Gene3Di3.60.40.10. 2 hits.
InterProiIPR001932. PP2C-like_dom.
IPR000222. PP2C_Mn2_Asp60_BS.
IPR015655. Protein_Pase_2C.
[Graphical view]
PANTHERiPTHR13832. PTHR13832. 1 hit.
PfamiPF00481. PP2C. 2 hits.
[Graphical view]
SMARTiSM00331. PP2C_SIG. 1 hit.
SM00332. PP2Cc. 1 hit.
[Graphical view]
SUPFAMiSSF81606. SSF81606. 2 hits.
PROSITEiPS01032. PP2C. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q61074-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGAYLSQPNT VKCSGDGVGA PRLPLPYGFS AMQGWRVSME DAHNCIPELD
60 70 80 90 100
NETAMFSVYD GHGGEEVALY CAKYLPDIIK DQKAYKEGKL QKALQDAFLA
110 120 130 140 150
IDAKLTTEEV IKELAQIAGR PTEDEDDKDK VADEDDVDNE EAALLHEEAT
160 170 180 190 200
MTIEELLTRY GQNCQKVPPH TKSGIGTGDE PGPQGLNGEA GPEDPSRETP
210 220 230 240 250
SQENGPTAKG HTGFSSNSEH GTEAGQISEP GTATGEAGPS CSSASDKLPR
260 270 280 290 300
VAKSKFFEDS EDESDEVEEE EDDSEECSED EDGYSSEEAE NEEDEDDTEE
310 320 330 340 350
AEEDDDEEMM VPGMEGKEEP GSDSGTTAVV ALIRGKQLIV ANAGDSRCVV
360 370 380 390 400
SEAGKALDMS YDHKPEDEVE LARIKNAGGK VTMDGRVNGG LNLSRAIGDH
410 420 430 440 450
FYKRNKNLPP QEQMISALPD IKVLTLTDDH EFMVIACDGI WNVMSSQEVV
460 470 480 490 500
DFIQSKISQR DENGELRLLS SIVEELLDQC LAPDTSGDGT GCDNMTCIII
510 520 530 540
CFKPRNTVEL QAESGKRKLE EALSTEGAED TGNSDKKKAK RD
Length:542
Mass (Da):58,728
Last modified:July 15, 1999 - v3
Checksum:i1DC72E7A66E71453
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti123 – 1264EDED → NSAR (PubMed:8649829).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC009004 mRNA. Translation: AAH09004.1.
U42383 mRNA. Translation: AAC26322.1.
CCDSiCCDS19179.1.
RefSeqiNP_032040.1. NM_008014.3.
UniGeneiMm.14501.

Genome annotation databases

EnsembliENSMUST00000031032; ENSMUSP00000031032; ENSMUSG00000029147.
GeneIDi14208.
KEGGimmu:14208.
UCSCiuc008wxr.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC009004 mRNA. Translation: AAH09004.1.
U42383 mRNA. Translation: AAC26322.1.
CCDSiCCDS19179.1.
RefSeqiNP_032040.1. NM_008014.3.
UniGeneiMm.14501.

3D structure databases

ProteinModelPortaliQ61074.
SMRiQ61074. Positions 1-126, 297-503.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ61074. 2 interactions.
MINTiMINT-1675839.
STRINGi10090.ENSMUSP00000031032.

PTM databases

PhosphoSiteiQ61074.

Proteomic databases

MaxQBiQ61074.
PaxDbiQ61074.
PRIDEiQ61074.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000031032; ENSMUSP00000031032; ENSMUSG00000029147.
GeneIDi14208.
KEGGimmu:14208.
UCSCiuc008wxr.1. mouse.

Organism-specific databases

CTDi5496.
MGIiMGI:106065. Ppm1g.

Phylogenomic databases

eggNOGiCOG0631.
GeneTreeiENSGT00770000120571.
HOGENOMiHOG000233896.
HOVERGENiHBG053647.
InParanoidiQ61074.
KOiK17499.
OMAiQEQMISA.
OrthoDBiEOG7034GD.
PhylomeDBiQ61074.
TreeFamiTF354280.

Miscellaneous databases

ChiTaRSiPpm1g. mouse.
NextBioi285454.
PROiQ61074.
SOURCEiSearch...

Gene expression databases

BgeeiQ61074.
GenevestigatoriQ61074.

Family and domain databases

Gene3Di3.60.40.10. 2 hits.
InterProiIPR001932. PP2C-like_dom.
IPR000222. PP2C_Mn2_Asp60_BS.
IPR015655. Protein_Pase_2C.
[Graphical view]
PANTHERiPTHR13832. PTHR13832. 1 hit.
PfamiPF00481. PP2C. 2 hits.
[Graphical view]
SMARTiSM00331. PP2C_SIG. 1 hit.
SM00332. PP2Cc. 1 hit.
[Graphical view]
SUPFAMiSSF81606. SSF81606. 2 hits.
PROSITEiPS01032. PP2C. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "FIN13, a novel growth factor-inducible serine-threonine phosphatase which can inhibit cell cycle progression."
    Guthridge M.A., Bellosta P., Tavoloni N., Basilico C.
    Mol. Cell. Biol. 17:5485-5498(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, SUBCELLULAR LOCATION.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: FVB/N.
    Tissue: Mammary gland.
  3. "Induction of expression of growth-related genes by FGF-4 in mouse fibroblasts."
    Guthridge M.A., Seldin M., Basilico C.
    Oncogene 12:1267-1278(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 123-420.
  4. "SIRT5-mediated lysine desuccinylation impacts diverse metabolic pathways."
    Park J., Chen Y., Tishkoff D.X., Peng C., Tan M., Dai L., Xie Z., Zhang Y., Zwaans B.M., Skinner M.E., Lombard D.B., Zhao Y.
    Mol. Cell 50:919-930(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-380, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Embryonic fibroblast.

Entry informationi

Entry nameiPPM1G_MOUSE
AccessioniPrimary (citable) accession number: Q61074
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: July 15, 1999
Last modified: March 4, 2015
This is version 130 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.