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Q61074

- PPM1G_MOUSE

UniProt

Q61074 - PPM1G_MOUSE

Protein

Protein phosphatase 1G

Gene

Ppm1g

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 125 (01 Oct 2014)
      Sequence version 3 (15 Jul 1999)
      Previous versions | rss
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    Functioni

    May be involved in regulation of cell cycle.1 Publication

    Catalytic activityi

    [a protein]-serine/threonine phosphate + H2O = [a protein]-serine/threonine + phosphate.

    Cofactori

    Binds 2 magnesium or manganese ions per subunit.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi60 – 601Manganese 1By similarity
    Metal bindingi60 – 601Manganese 2By similarity
    Metal bindingi61 – 611Manganese 1; via carbonyl oxygenBy similarity
    Metal bindingi438 – 4381Manganese 2By similarity
    Metal bindingi493 – 4931Manganese 2By similarity

    GO - Molecular functioni

    1. metal ion binding Source: UniProtKB-KW
    2. phosphoprotein phosphatase activity Source: MGI
    3. protein binding Source: MGI
    4. protein serine/threonine phosphatase activity Source: Ensembl

    GO - Biological processi

    1. cell cycle arrest Source: MGI
    2. peptidyl-threonine dephosphorylation Source: Ensembl
    3. protein dephosphorylation Source: MGI

    Keywords - Molecular functioni

    Hydrolase, Protein phosphatase

    Keywords - Biological processi

    Cell cycle

    Keywords - Ligandi

    Magnesium, Manganese, Metal-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Protein phosphatase 1G (EC:3.1.3.16)
    Alternative name(s):
    Fibroblast growth factor-inducible protein 13
    Short name:
    FIN13
    Protein phosphatase 1C
    Protein phosphatase 2C isoform gamma
    Short name:
    PP2C-gamma
    Protein phosphatase magnesium-dependent 1 gamma
    Gene namesi
    Name:Ppm1g
    Synonyms:Fin13, Ppm1c
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 5

    Organism-specific databases

    MGIiMGI:106065. Ppm1g.

    Subcellular locationi

    Nucleus 1 Publication

    GO - Cellular componenti

    1. nucleus Source: MGI

    Keywords - Cellular componenti

    Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 542542Protein phosphatase 1GPRO_0000057751Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei380 – 3801N6-acetyllysine1 Publication
    Modified residuei524 – 5241PhosphoserineBy similarity

    Keywords - PTMi

    Acetylation, Phosphoprotein

    Proteomic databases

    MaxQBiQ61074.
    PaxDbiQ61074.
    PRIDEiQ61074.

    PTM databases

    PhosphoSiteiQ61074.

    Expressioni

    Tissue specificityi

    Highly expressed in testis. Low level of expression in kidney. Also expressed in a number of tissues undergoing proliferation including embryo, uterus at pregnancy, placenta, and ovaries.

    Inductioni

    By FGF-4 and serum.

    Gene expression databases

    BgeeiQ61074.
    GenevestigatoriQ61074.

    Interactioni

    Protein-protein interaction databases

    IntActiQ61074. 2 interactions.
    MINTiMINT-1675839.
    STRINGi10090.ENSMUSP00000031032.

    Structurei

    3D structure databases

    ProteinModelPortaliQ61074.
    SMRiQ61074. Positions 1-126, 297-503.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi258 – 31962Asp/Glu-rich (acidic)Add
    BLAST

    Sequence similaritiesi

    Belongs to the PP2C family.Curated

    Phylogenomic databases

    eggNOGiCOG0631.
    GeneTreeiENSGT00730000110861.
    HOGENOMiHOG000233896.
    HOVERGENiHBG053647.
    InParanoidiQ61074.
    KOiK17499.
    OMAiMISAMPD.
    OrthoDBiEOG7034GD.
    PhylomeDBiQ61074.
    TreeFamiTF354280.

    Family and domain databases

    Gene3Di3.60.40.10. 2 hits.
    InterProiIPR001932. PP2C-like_dom.
    IPR000222. PP2C_Mn2_Asp60_BS.
    IPR015655. Protein_Pase_2C.
    [Graphical view]
    PANTHERiPTHR13832. PTHR13832. 1 hit.
    PfamiPF00481. PP2C. 2 hits.
    [Graphical view]
    SMARTiSM00331. PP2C_SIG. 1 hit.
    SM00332. PP2Cc. 1 hit.
    [Graphical view]
    SUPFAMiSSF81606. SSF81606. 2 hits.
    PROSITEiPS01032. PP2C. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q61074-1 [UniParc]FASTAAdd to Basket

    « Hide

    MGAYLSQPNT VKCSGDGVGA PRLPLPYGFS AMQGWRVSME DAHNCIPELD    50
    NETAMFSVYD GHGGEEVALY CAKYLPDIIK DQKAYKEGKL QKALQDAFLA 100
    IDAKLTTEEV IKELAQIAGR PTEDEDDKDK VADEDDVDNE EAALLHEEAT 150
    MTIEELLTRY GQNCQKVPPH TKSGIGTGDE PGPQGLNGEA GPEDPSRETP 200
    SQENGPTAKG HTGFSSNSEH GTEAGQISEP GTATGEAGPS CSSASDKLPR 250
    VAKSKFFEDS EDESDEVEEE EDDSEECSED EDGYSSEEAE NEEDEDDTEE 300
    AEEDDDEEMM VPGMEGKEEP GSDSGTTAVV ALIRGKQLIV ANAGDSRCVV 350
    SEAGKALDMS YDHKPEDEVE LARIKNAGGK VTMDGRVNGG LNLSRAIGDH 400
    FYKRNKNLPP QEQMISALPD IKVLTLTDDH EFMVIACDGI WNVMSSQEVV 450
    DFIQSKISQR DENGELRLLS SIVEELLDQC LAPDTSGDGT GCDNMTCIII 500
    CFKPRNTVEL QAESGKRKLE EALSTEGAED TGNSDKKKAK RD 542
    Length:542
    Mass (Da):58,728
    Last modified:July 15, 1999 - v3
    Checksum:i1DC72E7A66E71453
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti123 – 1264EDED → NSAR(PubMed:8649829)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC009004 mRNA. Translation: AAH09004.1.
    U42383 mRNA. Translation: AAC26322.1.
    CCDSiCCDS19179.1.
    RefSeqiNP_032040.1. NM_008014.3.
    UniGeneiMm.14501.

    Genome annotation databases

    EnsembliENSMUST00000031032; ENSMUSP00000031032; ENSMUSG00000029147.
    GeneIDi14208.
    KEGGimmu:14208.
    UCSCiuc008wxr.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC009004 mRNA. Translation: AAH09004.1 .
    U42383 mRNA. Translation: AAC26322.1 .
    CCDSi CCDS19179.1.
    RefSeqi NP_032040.1. NM_008014.3.
    UniGenei Mm.14501.

    3D structure databases

    ProteinModelPortali Q61074.
    SMRi Q61074. Positions 1-126, 297-503.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    IntActi Q61074. 2 interactions.
    MINTi MINT-1675839.
    STRINGi 10090.ENSMUSP00000031032.

    PTM databases

    PhosphoSitei Q61074.

    Proteomic databases

    MaxQBi Q61074.
    PaxDbi Q61074.
    PRIDEi Q61074.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000031032 ; ENSMUSP00000031032 ; ENSMUSG00000029147 .
    GeneIDi 14208.
    KEGGi mmu:14208.
    UCSCi uc008wxr.1. mouse.

    Organism-specific databases

    CTDi 5496.
    MGIi MGI:106065. Ppm1g.

    Phylogenomic databases

    eggNOGi COG0631.
    GeneTreei ENSGT00730000110861.
    HOGENOMi HOG000233896.
    HOVERGENi HBG053647.
    InParanoidi Q61074.
    KOi K17499.
    OMAi MISAMPD.
    OrthoDBi EOG7034GD.
    PhylomeDBi Q61074.
    TreeFami TF354280.

    Miscellaneous databases

    ChiTaRSi PPM1G. mouse.
    NextBioi 285454.
    PROi Q61074.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q61074.
    Genevestigatori Q61074.

    Family and domain databases

    Gene3Di 3.60.40.10. 2 hits.
    InterProi IPR001932. PP2C-like_dom.
    IPR000222. PP2C_Mn2_Asp60_BS.
    IPR015655. Protein_Pase_2C.
    [Graphical view ]
    PANTHERi PTHR13832. PTHR13832. 1 hit.
    Pfami PF00481. PP2C. 2 hits.
    [Graphical view ]
    SMARTi SM00331. PP2C_SIG. 1 hit.
    SM00332. PP2Cc. 1 hit.
    [Graphical view ]
    SUPFAMi SSF81606. SSF81606. 2 hits.
    PROSITEi PS01032. PP2C. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "FIN13, a novel growth factor-inducible serine-threonine phosphatase which can inhibit cell cycle progression."
      Guthridge M.A., Bellosta P., Tavoloni N., Basilico C.
      Mol. Cell. Biol. 17:5485-5498(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, SUBCELLULAR LOCATION.
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: FVB/N.
      Tissue: Mammary gland.
    3. "Induction of expression of growth-related genes by FGF-4 in mouse fibroblasts."
      Guthridge M.A., Seldin M., Basilico C.
      Oncogene 12:1267-1278(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 123-420.
    4. "SIRT5-mediated lysine desuccinylation impacts diverse metabolic pathways."
      Park J., Chen Y., Tishkoff D.X., Peng C., Tan M., Dai L., Xie Z., Zhang Y., Zwaans B.M., Skinner M.E., Lombard D.B., Zhao Y.
      Mol. Cell 50:919-930(2013) [PubMed] [Europe PMC] [Abstract]
      Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-380, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Embryonic fibroblast.

    Entry informationi

    Entry nameiPPM1G_MOUSE
    AccessioniPrimary (citable) accession number: Q61074
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 15, 1998
    Last sequence update: July 15, 1999
    Last modified: October 1, 2014
    This is version 125 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3