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Q61072

- ADAM9_MOUSE

UniProt

Q61072 - ADAM9_MOUSE

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Protein

Disintegrin and metalloproteinase domain-containing protein 9

Gene

Adam9

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Probable zinc protease. May mediate cell-cell or cell-matrix interactions.

Cofactori

Binds 1 zinc ion per subunit.Curated

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi347 – 3471Zinc; catalyticBy similarity
Active sitei348 – 3481By similarityPROSITE-ProRule annotation
Metal bindingi351 – 3511Zinc; catalyticBy similarity
Metal bindingi357 – 3571Zinc; catalyticBy similarity

GO - Molecular functioni

  1. metalloendopeptidase activity Source: BHF-UCL
  2. protein kinase C binding Source: BHF-UCL
  3. SH3 domain binding Source: BHF-UCL
  4. zinc ion binding Source: InterPro

GO - Biological processi

  1. activation of MAPKK activity Source: Ensembl
  2. cell-cell adhesion mediated by integrin Source: Ensembl
  3. cell-matrix adhesion Source: Ensembl
  4. cellular response to lipopolysaccharide Source: Ensembl
  5. keratinocyte differentiation Source: Ensembl
  6. membrane protein ectodomain proteolysis Source: BHF-UCL
  7. monocyte activation Source: Ensembl
  8. PMA-inducible membrane protein ectodomain proteolysis Source: Ensembl
  9. positive regulation of cell adhesion mediated by integrin Source: Ensembl
  10. positive regulation of keratinocyte migration Source: Ensembl
  11. positive regulation of macrophage fusion Source: Ensembl
  12. positive regulation of membrane protein ectodomain proteolysis Source: BHF-UCL
  13. positive regulation of protein secretion Source: Ensembl
  14. response to calcium ion Source: Ensembl
  15. response to glucocorticoid Source: BHF-UCL
  16. response to hydrogen peroxide Source: Ensembl
  17. response to laminar fluid shear stress Source: Ensembl
  18. response to manganese ion Source: Ensembl
  19. response to tumor necrosis factor Source: Ensembl
  20. transforming growth factor beta receptor signaling pathway Source: BHF-UCL
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Metalloprotease, Protease

Keywords - Ligandi

Metal-binding, Zinc

Enzyme and pathway databases

ReactomeiREACT_199055. Collagen degradation.

Protein family/group databases

MEROPSiM12.209.

Names & Taxonomyi

Protein namesi
Recommended name:
Disintegrin and metalloproteinase domain-containing protein 9 (EC:3.4.24.-)
Short name:
ADAM 9
Alternative name(s):
Meltrin-gamma
Metalloprotease/disintegrin/cysteine-rich protein 9
Myeloma cell metalloproteinase
Gene namesi
Name:Adam9Imported
Synonyms:Kiaa0021Imported, Mdc9, Mltng
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 8

Organism-specific databases

MGIiMGI:105376. Adam9.

Subcellular locationi

GO - Cellular componenti

  1. basolateral plasma membrane Source: Ensembl
  2. cell surface Source: BHF-UCL
  3. cytoplasm Source: MGI
  4. extracellular space Source: BHF-UCL
  5. integral component of membrane Source: UniProtKB-KW
  6. intrinsic component of external side of plasma membrane Source: BHF-UCL
  7. plasma membrane Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2929Sequence AnalysisAdd
BLAST
Chaini30 – 845816Disintegrin and metalloproteinase domain-containing protein 9PRO_0000029063Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi144 – 1441N-linked (GlcNAc...)Sequence Analysis
Glycosylationi154 – 1541N-linked (GlcNAc...)Sequence Analysis
Glycosylationi231 – 2311N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi322 ↔ 401By similarity
Disulfide bondi363 ↔ 385By similarity
Disulfide bondi365 ↔ 370By similarity
Glycosylationi381 – 3811N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi473 ↔ 493By similarity
Glycosylationi487 – 4871N-linked (GlcNAc...)Sequence Analysis
Glycosylationi636 – 6361N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi644 ↔ 656By similarity
Disulfide bondi650 ↔ 662By similarity
Disulfide bondi664 ↔ 673By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

MaxQBiQ61072.
PaxDbiQ61072.
PRIDEiQ61072.

PTM databases

PhosphoSiteiQ61072.

Expressioni

Gene expression databases

BgeeiQ61072.
ExpressionAtlasiQ61072. baseline and differential.
GenevestigatoriQ61072.

Interactioni

Subunit structurei

Interacts with SH3GL2 and SNX9 through its cytoplasmic tail.1 Publication

Protein-protein interaction databases

IntActiQ61072. 2 interactions.
MINTiMINT-252904.

Structurei

3D structure databases

ProteinModelPortaliQ61072.
SMRiQ61072. Positions 212-638.
ModBaseiSearch...
MobiDBiSearch...

Topological domain

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini30 – 697668ExtracellularSequence AnalysisAdd
BLAST
Topological domaini719 – 845127CytoplasmicSequence AnalysisAdd
BLAST

Transmembrane

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei698 – 71821HelicalSequence AnalysisAdd
BLAST

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini212 – 406195Peptidase M12BPROSITE-ProRule annotationAdd
BLAST
Domaini414 – 50188DisintegrinPROSITE-ProRule annotationAdd
BLAST
Domaini644 – 69855EGF-likePROSITE-ProRule annotationAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi505 – 634130Cys-richAdd
BLAST

Sequence similaritiesi

Contains 1 disintegrin domain.PROSITE-ProRule annotation
Contains 1 EGF-like domain.PROSITE-ProRule annotation
Contains 1 peptidase M12B domain.PROSITE-ProRule annotation

Keywords - Domaini

EGF-like domain, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG294463.
GeneTreeiENSGT00760000118888.
HOGENOMiHOG000230883.
HOVERGENiHBG006978.
InParanoidiQ61072.
KOiK06834.
OMAiFCQPDVF.
OrthoDBiEOG7F7W89.
TreeFamiTF314733.

Family and domain databases

Gene3Di3.40.390.10. 1 hit.
4.10.70.10. 1 hit.
InterProiIPR006586. ADAM_Cys-rich.
IPR001762. Blood-coag_inhib_Disintegrin.
IPR018358. Disintegrin_CS.
IPR000742. EG-like_dom.
IPR013032. EGF-like_CS.
IPR024079. MetalloPept_cat_dom.
IPR001590. Peptidase_M12B.
IPR002870. Peptidase_M12B_N.
[Graphical view]
PfamiPF08516. ADAM_CR. 1 hit.
PF00200. Disintegrin. 1 hit.
PF01562. Pep_M12B_propep. 1 hit.
PF01421. Reprolysin. 1 hit.
[Graphical view]
PRINTSiPR00289. DISINTEGRIN.
SMARTiSM00608. ACR. 1 hit.
SM00050. DISIN. 1 hit.
SM00181. EGF. 1 hit.
[Graphical view]
SUPFAMiSSF57552. SSF57552. 1 hit.
PROSITEiPS50215. ADAM_MEPRO. 1 hit.
PS00427. DISINTEGRIN_1. 1 hit.
PS50214. DISINTEGRIN_2. 1 hit.
PS01186. EGF_2. 1 hit.
PS50026. EGF_3. 1 hit.
PS00142. ZINC_PROTEASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q61072-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MGPRALSPLA SLRLRWLLAC GLLGPVLEAG RPDLEQTVHL SSYEIITPWR
60 70 80 90 100
LTRERREALG PSSQQISYVI QAQGKQHIIH LERNTDLLPN DFVVYTYDKE
110 120 130 140 150
GSLLSDHPNV QSHCHYRGYV EGVQNSAVAV SACFGLRGLL HLENASFGIE
160 170 180 190 200
PLHNSSHFEH IFYPMDGIHQ EPLRCGVSNR DTEKEGTQGD EEEHPSVTQL
210 220 230 240 250
LRRRRAVLPQ TRYVELFIVV DKERYDMMGR NQTAVREEMI RLANYLDSMY
260 270 280 290 300
IMLNIRIVLV GLEIWTDRNP INIIGGAGDV LGNFVQWREK FLITRWRHDS
310 320 330 340 350
AQLVLKKGFG GTAGMAFVGT VCSRSHAGGI NVFGQITVET FASIVAHELG
360 370 380 390 400
HNLGMNHDDG RECFCGAKSC IMNSGASGSR NFSSCSAEDF EKLTLNKGGS
410 420 430 440 450
CLLNIPKPDE AYSAPSCGNK LVDPGEECDC GTAKECEVDP CCEGSTCKLK
460 470 480 490 500
SFAECAYGDC CKDCQFLPGG SMCRGKTSEC DVPEYCNGSS QFCPPDVFIQ
510 520 530 540 550
NGYPCQNSKA YCYNGMCQYY DAQCQVIFGS KAKAAPRDCF IEVNSKGDRF
560 570 580 590 600
GNCGFSGSEY KKCATGNALC GKLQCENVQD MPVFGIVPAI IQTPSRGTKC
610 620 630 640 650
WGVDFQLGSD VPDPGMVNEG TKCDAGKICR NFQCVNASVL NYDCDIQGKC
660 670 680 690 700
HGHGVCNSNK NCHCEDGWAP PHCDTKGYGG SVDSGPTYNA KSTALRDGLL
710 720 730 740 750
VFFFLIVPLV AAAIFLFIKR DELRKTFRKK RSQMSDGRNQ ANVSRQPGDP
760 770 780 790 800
SISRPPGGPN VSRPPGGPGV SRPPGGPGVS RPPGGPGVSR PPPGHGNRFP
810 820 830 840
VPTYAAKQPA QFPSRPPPPQ PKISSQGNLI PARPAPAPPL YSSLT
Length:845
Mass (Da):92,079
Last modified:July 27, 2011 - v2
Checksum:i38C40F89D4A77725
GO

Sequence cautioni

The sequence BAC65470.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti296 – 2961W → R in AAC52446. (PubMed:8647900)Curated
Sequence conflicti296 – 2961W → R in BAC65470. (PubMed:12693553)Curated
Sequence conflicti296 – 2961W → R in AAH47156. (PubMed:15489334)Curated

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U41765 mRNA. Translation: AAC52446.1.
AK122188 mRNA. Translation: BAC65470.1. Different initiation.
AC156553 Genomic DNA. No translation available.
BC047156 mRNA. Translation: AAH47156.1.
D50412 mRNA. Translation: BAA08913.1.
U06145 mRNA. Translation: AAA18424.1.
PIRiI48943.
S60259.
RefSeqiNP_031430.2. NM_007404.2.
UniGeneiMm.28908.

Genome annotation databases

EnsembliENSMUST00000084035; ENSMUSP00000081048; ENSMUSG00000031555.
GeneIDi11502.
KEGGimmu:11502.
UCSCiuc009lfk.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U41765 mRNA. Translation: AAC52446.1 .
AK122188 mRNA. Translation: BAC65470.1 . Different initiation.
AC156553 Genomic DNA. No translation available.
BC047156 mRNA. Translation: AAH47156.1 .
D50412 mRNA. Translation: BAA08913.1 .
U06145 mRNA. Translation: AAA18424.1 .
PIRi I48943.
S60259.
RefSeqi NP_031430.2. NM_007404.2.
UniGenei Mm.28908.

3D structure databases

ProteinModelPortali Q61072.
SMRi Q61072. Positions 212-638.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

IntActi Q61072. 2 interactions.
MINTi MINT-252904.

Protein family/group databases

MEROPSi M12.209.

PTM databases

PhosphoSitei Q61072.

Proteomic databases

MaxQBi Q61072.
PaxDbi Q61072.
PRIDEi Q61072.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000084035 ; ENSMUSP00000081048 ; ENSMUSG00000031555 .
GeneIDi 11502.
KEGGi mmu:11502.
UCSCi uc009lfk.2. mouse.

Organism-specific databases

CTDi 8754.
MGIi MGI:105376. Adam9.
Rougei Search...

Phylogenomic databases

eggNOGi NOG294463.
GeneTreei ENSGT00760000118888.
HOGENOMi HOG000230883.
HOVERGENi HBG006978.
InParanoidi Q61072.
KOi K06834.
OMAi FCQPDVF.
OrthoDBi EOG7F7W89.
TreeFami TF314733.

Enzyme and pathway databases

Reactomei REACT_199055. Collagen degradation.

Miscellaneous databases

NextBioi 278906.
PROi Q61072.
SOURCEi Search...

Gene expression databases

Bgeei Q61072.
ExpressionAtlasi Q61072. baseline and differential.
Genevestigatori Q61072.

Family and domain databases

Gene3Di 3.40.390.10. 1 hit.
4.10.70.10. 1 hit.
InterProi IPR006586. ADAM_Cys-rich.
IPR001762. Blood-coag_inhib_Disintegrin.
IPR018358. Disintegrin_CS.
IPR000742. EG-like_dom.
IPR013032. EGF-like_CS.
IPR024079. MetalloPept_cat_dom.
IPR001590. Peptidase_M12B.
IPR002870. Peptidase_M12B_N.
[Graphical view ]
Pfami PF08516. ADAM_CR. 1 hit.
PF00200. Disintegrin. 1 hit.
PF01562. Pep_M12B_propep. 1 hit.
PF01421. Reprolysin. 1 hit.
[Graphical view ]
PRINTSi PR00289. DISINTEGRIN.
SMARTi SM00608. ACR. 1 hit.
SM00050. DISIN. 1 hit.
SM00181. EGF. 1 hit.
[Graphical view ]
SUPFAMi SSF57552. SSF57552. 1 hit.
PROSITEi PS50215. ADAM_MEPRO. 1 hit.
PS00427. DISINTEGRIN_1. 1 hit.
PS50214. DISINTEGRIN_2. 1 hit.
PS01186. EGF_2. 1 hit.
PS50026. EGF_3. 1 hit.
PS00142. ZINC_PROTEASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "MDC9, a widely expressed cellular disintegrin containing cytoplasmic SH3 ligand domains."
    Weskamp G., Kraetzschmar J., Reid M.S., Blobel C.P.
    J. Cell Biol. 132:717-726(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Lung.
  2. "Prediction of the coding sequences of mouse homologues of KIAA gene: II. The complete nucleotide sequences of 400 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries."
    Okazaki N., Kikuno R., Ohara R., Inamoto S., Aizawa H., Yuasa S., Nakajima D., Nagase T., Ohara O., Koga H.
    DNA Res. 10:35-48(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: BrainImported.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: FVB/N-3.
    Tissue: Mammary gland.
  5. "A metalloprotease-disintegrin participating in myoblast fusion."
    Yagami-Hiromasa T., Sato T., Kurisaki T., Kamijo K., Nabeshima Y., Fujisawa-Sehara A.
    Nature 377:652-656(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 426-575.
  6. "A family of cellular proteins related to snake venom disintegrins."
    Weskamp G., Blobel C.P.
    Proc. Natl. Acad. Sci. U.S.A. 91:2748-2751(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 432-478.
    Strain: BALB/c.
  7. "Interaction of the metalloprotease disintegrins MDC9 and MDC15 with two SH3 domain-containing proteins, endophilin I and SH3PX1."
    Howard L., Nelson K.K., Maciewicz R.A., Blobel C.P.
    J. Biol. Chem. 274:31693-31699(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH SH3GL2 AND SNX9.

Entry informationi

Entry nameiADAM9_MOUSE
AccessioniPrimary (citable) accession number: Q61072
Secondary accession number(s): E9QPP2
, Q60618, Q61853, Q80U94
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 19, 2004
Last sequence update: July 27, 2011
Last modified: October 29, 2014
This is version 123 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. Peptidase families
    Classification of peptidase families and list of entries
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3