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Reviewed, UniProtKB/Swiss-Prot Q61072 (ADAM9_MOUSE)

Last modified June 16, 2009. Version 73. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Binary interactions · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

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Names and origin

Protein namesRecommended name:
    Disintegrin and metalloproteinase domain-containing protein 9
      Short name=ADAM 9
    EC=3.4.24.-
Alternative name(s):
    Metalloprotease/disintegrin/cysteine-rich protein 9
    Myeloma cell metalloproteinase
    Meltrin-gamma
Gene names
Name: Adam9
Synonyms: Kiaa0021, Mdc9, Mltng
OrganismMus musculus (Mouse)
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus

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Protein attributes

Sequence length845 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level.

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General annotation (Comments)

Function

Probable zinc protease. May mediate cell-cell or cell-matrix interactions.

Cofactor

Binds 1 zinc ion per subunit Probable.

Subcellular location

Membrane; Single-pass type I membrane protein Probable.

Sequence similarities

Contains 1 disintegrin domain.

Contains 1 EGF-like domain.

Contains 1 peptidase M12B domain.

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Binary interactions

With

Entry

#Exp.

IntAct

Notes

Pacsin3Q99JB81EBI-77983,EBI-77834
Sh3gl2Q624201EBI-77983,EBI-77971

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Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2929 Potential
Chain30 – 845816Disintegrin and metalloproteinase domain-containing protein 9
PRO_0000029063

Regions

Topological domain30 – 697668Extracellular Potential
Transmembrane698 – 71821 Potential
Topological domain719 – 845127Cytoplasmic Potential
Domain212 – 406195Peptidase M12B
Domain414 – 50188Disintegrin
Domain644 – 69855EGF-like
Compositional bias505 – 634130Cys-rich

Sites

Active site3481 By similarity UniProtKB P78536
Metal binding3471Zinc; catalytic By similarity UniProtKB P78536
Metal binding3511Zinc; catalytic By similarity UniProtKB P78536
Metal binding3571Zinc; catalytic By similarity UniProtKB P78536

Amino acid modifications

Modified residue8411Phosphotyrosine By similarity
Glycosylation1441N-linked (GlcNAc...) Potential
Glycosylation1541N-linked (GlcNAc...) Potential
Glycosylation2311N-linked (GlcNAc...) Potential
Glycosylation3811N-linked (GlcNAc...) Potential
Glycosylation4871N-linked (GlcNAc...) Potential
Glycosylation6361N-linked (GlcNAc...) Potential
Disulfide bond322 ↔ 401 By similarity
Disulfide bond363 ↔ 385 By similarity UniProtKB P78536
Disulfide bond365 ↔ 370 By similarity
Disulfide bond473 ↔ 493 By similarity
Disulfide bond644 ↔ 656 By similarity
Disulfide bond650 ↔ 662 By similarity
Disulfide bond664 ↔ 673 By similarity

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Sequences

Sequence LengthMass (Da)Tools
Q61072-1 [UniParc].

Last modified November 1, 1996. Version 1.
Checksum: 17562E89D4A61674

FASTA84592,049
        10         20         30         40         50         60 
MGPRALSPLA SLRLRWLLAC GLLGPVLEAG RPDLEQTVHL SSYEIITPWR LTRERREALG 

        70         80         90        100        110        120 
PSSQQISYVI QAQGKQHIIH LERNTDLLPN DFVVYTYDKE GSLLSDHPNV QSHCHYRGYV 

       130        140        150        160        170        180 
EGVQNSAVAV SACFGLRGLL HLENASFGIE PLHNSSHFEH IFYPMDGIHQ EPLRCGVSNR 

       190        200        210        220        230        240 
DTEKEGTQGD EEEHPSVTQL LRRRRAVLPQ TRYVELFIVV DKERYDMMGR NQTAVREEMI 

       250        260        270        280        290        300 
RLANYLDSMY IMLNIRIVLV GLEIWTDRNP INIIGGAGDV LGNFVQWREK FLITRRRHDS 

       310        320        330        340        350        360 
AQLVLKKGFG GTAGMAFVGT VCSRSHAGGI NVFGQITVET FASIVAHELG HNLGMNHDDG 

       370        380        390        400        410        420 
RECFCGAKSC IMNSGASGSR NFSSCSAEDF EKLTLNKGGS CLLNIPKPDE AYSAPSCGNK 

       430        440        450        460        470        480 
LVDPGEECDC GTAKECEVDP CCEGSTCKLK SFAECAYGDC CKDCQFLPGG SMCRGKTSEC 

       490        500        510        520        530        540 
DVPEYCNGSS QFCPPDVFIQ NGYPCQNSKA YCYNGMCQYY DAQCQVIFGS KAKAAPRDCF 

       550        560        570        580        590        600 
IEVNSKGDRF GNCGFSGSEY KKCATGNALC GKLQCENVQD MPVFGIVPAI IQTPSRGTKC 

       610        620        630        640        650        660 
WGVDFQLGSD VPDPGMVNEG TKCDAGKICR NFQCVNASVL NYDCDIQGKC HGHGVCNSNK 

       670        680        690        700        710        720 
NCHCEDGWAP PHCDTKGYGG SVDSGPTYNA KSTALRDGLL VFFFLIVPLV AAAIFLFIKR 

       730        740        750        760        770        780 
DELRKTFRKK RSQMSDGRNQ ANVSRQPGDP SISRPPGGPN VSRPPGGPGV SRPPGGPGVS 

       790        800        810        820        830        840 
RPPGGPGVSR PPPGHGNRFP VPTYAAKQPA QFPSRPPPPQ PKISSQGNLI PARPAPAPPL 


YSSLT

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References

« Hide 'large scale' references
[1]"MDC9, a widely expressed cellular disintegrin containing cytoplasmic SH3 ligand domains."
Weskamp G., Kraetzschmar J., Reid M.S., Blobel C.P.
J. Cell Biol. 132:717-726(1996) [PubMed: 8647900] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Lung.
[2]"Prediction of the coding sequences of mouse homologues of KIAA gene: II. The complete nucleotide sequences of 400 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries."
Okazaki N., Kikuno R., Ohara R., Inamoto S., Aizawa H., Yuasa S., Nakajima D., Nagase T., Ohara O., Koga H.
DNA Res. 10:35-48(2003) [PubMed: 12693553] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Brain.
[3]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: FVB/N-3.
Tissue: Mammary gland.
[4]"A metalloprotease-disintegrin participating in myoblast fusion."
Yagami-Hiromasa T., Sato T., Kurisaki T., Kamijo K., Nabeshima Y., Fujisawa-Sehara A.
Nature 377:652-656(1995) [PubMed: 7566181] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 426-575.
[5]"A family of cellular proteins related to snake venom disintegrins."
Weskamp G., Blobel C.P.
Proc. Natl. Acad. Sci. U.S.A. 91:2748-2751(1994) [PubMed: 8146185] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 432-478.
Strain: BALB/c.
+Additional computationally mapped references.

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Cross-references

Sequence databases

U06145 mRNA. Translation: AAA18424.1.
AK122188 mRNA. Translation: BAC65470.1. Different initiation.
BC047156 mRNA. Translation: AAH47156.1.
U41765 mRNA. Translation: AAC52446.1.
D50412 mRNA. Translation: BAA08913.1.
IPIIPI00626485.
PIRI48943.
S60259.
UniGeneMm.28908

3D structure databases

HSSPHSSP built from PDB template 1FVL based on UniProtKB P18619.
ModBaseSearch...

Protein-protein interaction databases

IntActQ61072. 2 interactions.

Protein family/group databases

MEROPSM12.209.

PTM databases

PhosphoSiteQ61072.

Proteomic databases

PRIDEQ61072.

Genome annotation databases

EnsemblENSMUSG00000031555. Mus musculus. [Contig view]

Organism-specific databases

MGIMGI:105376. Adam9.
RougeSearch...

Phylogenomic databases

HOGENOMQ61072.
HOVERGENQ61072.

Gene expression databases

ArrayExpressQ61072.
BgeeQ61072.
GermOnlineENSMUSG00000031555. Mus musculus.

Family and domain databases

InterProIPR006586. ADAM_Cys-rich.
IPR001762. Blood-coag_inhib_Disintegrin.
IPR018358. Disintegrin_CS.
IPR006210. EGF-like.
IPR013032. EGF-like_reg_CS.
IPR000742. EGF_3.
IPR013111. EGF_extracell.
IPR006025. Pept_M_Zn_BS.
IPR001590. Peptidase_M12B.
IPR002870. Peptidase_M12B_N.
[Graphical view]
Gene3DG3DSA:4.10.70.10. Blood-coag_inhib_Disintegrin. 1 hit.
PfamPF08516. ADAM_CR. 1 hit.
PF00200. Disintegrin. 1 hit.
PF07974. EGF_2. 1 hit.
PF01562. Pep_M12B_propep. 1 hit.
PF01421. Reprolysin. 1 hit.
[Graphical view]
PRINTSPR00289. DISINTEGRIN.
ProDomPD000664. Disintegrin. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SMARTSM00608. ACR. 1 hit.
SM00050. DISIN. 1 hit.
SM00181. EGF. 1 hit.
[Graphical view]
PROSITEPS50215. ADAM_MEPRO. 1 hit.
PS00427. DISINTEGRIN_1. 1 hit.
PS50214. DISINTEGRIN_2. 1 hit.
PS00022. EGF_1. False negative.
PS01186. EGF_2. 1 hit.
PS50026. EGF_3. 1 hit.
PS00142. ZINC_PROTEASE. 1 hit.
[Graphical view]
ProtoNetSearch...

Other Resources

SOURCESearch...

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Entry information

Entry nameADAM9_MOUSE
AccessionPrimary (citable) accession number: Q61072
Secondary accession number(s): Q60618, Q61853, Q80U94
Entry history
Integrated into UniProtKB/Swiss-Prot: July 19, 2004
Last sequence update: November 1, 1996
Last modified: June 16, 2009
This is version 73 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHPI (Human Proteome Initiative)

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Relevant documents

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

Peptidase families

Classification of peptidase families and list of entries

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Binary interactions · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents