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Q61069 (USF1_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified May 1, 2013. Version 90. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Upstream stimulatory factor 1
Alternative name(s):
Major late transcription factor 1
Gene names
Name:Usf1
Synonyms:Usf
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length310 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Transcription factor that binds to a symmetrical DNA sequence (E-boxes) (5'-CACGTG-3') that is found in a variety of viral and cellular promoters.

Subunit structure

Efficient DNA binding requires dimerization with another bHLH protein. Binds DNA as a homodimer or a heterodimer (USF1/USF2).

Subcellular location

Nucleus.

Sequence similarities

Contains 1 bHLH (basic helix-loop-helix) domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 310310Upstream stimulatory factor 1
PRO_0000127497

Regions

Domain199 – 25456bHLH
Region271 – 29222Leucine-zipper

Sequences

Sequence LengthMass (Da)Tools
Q61069 [UniParc].

Last modified November 1, 1996. Version 1.
Checksum: 7D0AF808A2FDFA1C

FASTA31033,570
        10         20         30         40         50         60 
MKGQQKTAET EEGTVQIQEG AVATGEDPTS VAIASIQSAA TFPDPNVKYV FRTENGGQVM 

        70         80         90        100        110        120 
YRVIQVSEGQ LDGQTEGSGA ISGYPATQSM TQAVIQGAFT SDDAVDTEGA AAETHYTYFP 

       130        140        150        160        170        180 
STAVGDGSGG TTSGSTTAVV TTQGSEALLG QATPPSTGQF FVMMSPQEVL QGGSQRSIAP 

       190        200        210        220        230        240 
RTHPYSPKSE APRTTRDEKR RAQHNEVERR RRDKINNWIV QLSKIIPDCS MESTKSGQSK 

       250        260        270        280        290        300 
GGILSKACDY IQELRQSNHR LSEELQGLDQ LQLDNDVLRQ QVEDLKNKNL LLRAQLRHHG 

       310 
LEVVIKNDSN

« Hide

References

[1]"Complete sequencing of the murine USF gene and comparison of its genomic organization to that of mFIP/USF2."
Aperlo C., Boulukos K.E., Sage J., Cuzin F., Pognonec P.
Genomics 37:337-344(1996) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: C57BL/6.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		U41741 Genomic DNA. Translation: AAC52921.1.
IPIIPI00117062.
RefSeqNP_033506.1. NM_009480.2.
UniGeneMm.8.

3D structure databases

ProteinModelPortalQ61069.
SMRQ61069. Positions 197-287.
ModBaseSearch...

Protein-protein interaction databases

STRING10090.ENSMUSP00000001284.

PTM databases

PhosphoSiteQ61069.

Proteomic databases

PaxDbQ61069.
PRIDEQ61069.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000161241; ENSMUSP00000125729; ENSMUSG00000026641.
ENSMUST00000167546; ENSMUSP00000128913; ENSMUSG00000026641.
GeneID22278.
KEGGmmu:22278.

Organism-specific databases

CTD7391.
MGIMGI:99542. Usf1.

Phylogenomic databases

eggNOGNOG272240.
GeneTreeENSGT00390000004498.
HOVERGENHBG004346.
InParanoidQ61069.
KOK09106.
OMATETHYTY.
OrthoDBEOG41C6WV.

Gene expression databases

ArrayExpressQ61069.
BgeeQ61069.
CleanExMM_USF1.
GenevestigatorQ61069.
GermOnlineENSMUSG00000026641. Mus musculus.

Family and domain databases

Gene3D4.10.280.10. 1 hit.
InterProIPR011598. bHLH_dom.
[Graphical view]
PfamPF00010. HLH. 1 hit.
[Graphical view]
SMARTSM00353. HLH. 1 hit.
[Graphical view]
SUPFAMSSF47459. HLH_basic. 1 hit.
PROSITEPS50888. BHLH. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio302403.
SOURCESearch...

Entry information

Entry nameUSF1_MOUSE
AccessionPrimary (citable) accession number: Q61069
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1996
Last modified: May 1, 2013
This is version 90 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

SIMILARITY comments

Index of protein domains and families

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