Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Upstream stimulatory factor 1

Gene

Usf1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Transcription factor that binds to a symmetrical DNA sequence (E-boxes) (5'-CACGTG-3') that is found in a variety of viral and cellular promoters.

GO - Molecular functioni

GO - Biological processi

  • cellular response to insulin stimulus Source: MGI
  • glucose metabolic process Source: Ensembl
  • late viral transcription Source: MGI
  • lipid homeostasis Source: BHF-UCL
  • positive regulation of transcription, DNA-templated Source: MGI
  • positive regulation of transcription from RNA polymerase II promoter Source: MGI
  • positive regulation of transcription from RNA polymerase II promoter by glucose Source: BHF-UCL
  • response to hypoxia Source: MGI
  • response to UV Source: BHF-UCL
  • transcription from RNA polymerase II promoter Source: MGI
Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Upstream stimulatory factor 1
Alternative name(s):
Major late transcription factor 1
Gene namesi
Name:Usf1
Synonyms:Usf
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589 Componenti: Chromosome 1

Organism-specific databases

MGIiMGI:99542. Usf1.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 310310Upstream stimulatory factor 1PRO_0000127497Add
BLAST

Proteomic databases

MaxQBiQ61069.
PaxDbiQ61069.
PRIDEiQ61069.

PTM databases

PhosphoSiteiQ61069.

Expressioni

Gene expression databases

BgeeiQ61069.
CleanExiMM_USF1.
ExpressionAtlasiQ61069. baseline and differential.
GenevisibleiQ61069. MM.

Interactioni

Subunit structurei

Efficient DNA binding requires dimerization with another bHLH protein. Binds DNA as a homodimer or a heterodimer (USF1/USF2).

Binary interactionsi

WithEntry#Exp.IntActNotes
Stat1P422252EBI-2325635,EBI-647118

Protein-protein interaction databases

BioGridi204464. 5 interactions.
IntActiQ61069. 1 interaction.
STRINGi10090.ENSMUSP00000125729.

Structurei

3D structure databases

ProteinModelPortaliQ61069.
SMRiQ61069. Positions 197-260.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini199 – 25456bHLHPROSITE-ProRule annotationAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni271 – 29222Leucine-zipperAdd
BLAST

Sequence similaritiesi

Contains 1 bHLH (basic helix-loop-helix) domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiNOG272240.
GeneTreeiENSGT00390000004498.
HOVERGENiHBG004346.
InParanoidiQ61069.
KOiK09106.
OMAiYTYYPAT.
OrthoDBiEOG7GXPBW.
PhylomeDBiQ61069.
TreeFamiTF323338.

Family and domain databases

Gene3Di4.10.280.10. 1 hit.
InterProiIPR011598. bHLH_dom.
[Graphical view]
PfamiPF00010. HLH. 1 hit.
[Graphical view]
SMARTiSM00353. HLH. 1 hit.
[Graphical view]
SUPFAMiSSF47459. SSF47459. 1 hit.
PROSITEiPS50888. BHLH. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q61069-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKGQQKTAET EEGTVQIQEG AVATGEDPTS VAIASIQSAA TFPDPNVKYV
60 70 80 90 100
FRTENGGQVM YRVIQVSEGQ LDGQTEGSGA ISGYPATQSM TQAVIQGAFT
110 120 130 140 150
SDDAVDTEGA AAETHYTYFP STAVGDGSGG TTSGSTTAVV TTQGSEALLG
160 170 180 190 200
QATPPSTGQF FVMMSPQEVL QGGSQRSIAP RTHPYSPKSE APRTTRDEKR
210 220 230 240 250
RAQHNEVERR RRDKINNWIV QLSKIIPDCS MESTKSGQSK GGILSKACDY
260 270 280 290 300
IQELRQSNHR LSEELQGLDQ LQLDNDVLRQ QVEDLKNKNL LLRAQLRHHG
310
LEVVIKNDSN
Length:310
Mass (Da):33,570
Last modified:November 1, 1996 - v1
Checksum:i7D0AF808A2FDFA1C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U41741 Genomic DNA. Translation: AAC52921.1.
CCDSiCCDS15495.1.
RefSeqiNP_033506.1. NM_009480.3.
UniGeneiMm.8.

Genome annotation databases

EnsembliENSMUST00000161241; ENSMUSP00000125729; ENSMUSG00000026641.
ENSMUST00000167546; ENSMUSP00000128913; ENSMUSG00000026641.
GeneIDi22278.
KEGGimmu:22278.
UCSCiuc007doj.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U41741 Genomic DNA. Translation: AAC52921.1.
CCDSiCCDS15495.1.
RefSeqiNP_033506.1. NM_009480.3.
UniGeneiMm.8.

3D structure databases

ProteinModelPortaliQ61069.
SMRiQ61069. Positions 197-260.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi204464. 5 interactions.
IntActiQ61069. 1 interaction.
STRINGi10090.ENSMUSP00000125729.

PTM databases

PhosphoSiteiQ61069.

Proteomic databases

MaxQBiQ61069.
PaxDbiQ61069.
PRIDEiQ61069.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000161241; ENSMUSP00000125729; ENSMUSG00000026641.
ENSMUST00000167546; ENSMUSP00000128913; ENSMUSG00000026641.
GeneIDi22278.
KEGGimmu:22278.
UCSCiuc007doj.1. mouse.

Organism-specific databases

CTDi7391.
MGIiMGI:99542. Usf1.

Phylogenomic databases

eggNOGiNOG272240.
GeneTreeiENSGT00390000004498.
HOVERGENiHBG004346.
InParanoidiQ61069.
KOiK09106.
OMAiYTYYPAT.
OrthoDBiEOG7GXPBW.
PhylomeDBiQ61069.
TreeFamiTF323338.

Miscellaneous databases

NextBioi302403.
PROiQ61069.
SOURCEiSearch...

Gene expression databases

BgeeiQ61069.
CleanExiMM_USF1.
ExpressionAtlasiQ61069. baseline and differential.
GenevisibleiQ61069. MM.

Family and domain databases

Gene3Di4.10.280.10. 1 hit.
InterProiIPR011598. bHLH_dom.
[Graphical view]
PfamiPF00010. HLH. 1 hit.
[Graphical view]
SMARTiSM00353. HLH. 1 hit.
[Graphical view]
SUPFAMiSSF47459. SSF47459. 1 hit.
PROSITEiPS50888. BHLH. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Complete sequencing of the murine USF gene and comparison of its genomic organization to that of mFIP/USF2."
    Aperlo C., Boulukos K.E., Sage J., Cuzin F., Pognonec P.
    Genomics 37:337-344(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: C57BL/6.

Entry informationi

Entry nameiUSF1_MOUSE
AccessioniPrimary (citable) accession number: Q61069
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1996
Last modified: June 24, 2015
This is version 110 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.