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Q61069

- USF1_MOUSE

UniProt

Q61069 - USF1_MOUSE

Protein

Upstream stimulatory factor 1

Gene

Usf1

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 103 (01 Oct 2014)
      Sequence version 1 (01 Nov 1996)
      Previous versions | rss
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    Functioni

    Transcription factor that binds to a symmetrical DNA sequence (E-boxes) (5'-CACGTG-3') that is found in a variety of viral and cellular promoters.

    GO - Molecular functioni

    1. DNA binding Source: MGI
    2. double-stranded DNA binding Source: Ensembl
    3. protein binding Source: IntAct
    4. RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity Source: Ensembl
    5. sequence-specific DNA binding Source: Ensembl
    6. sequence-specific DNA binding transcription factor activity Source: MGI

    GO - Biological processi

    1. cellular response to insulin stimulus Source: Ensembl
    2. glucose metabolic process Source: Ensembl
    3. late viral transcription Source: Ensembl
    4. lipid homeostasis Source: BHF-UCL
    5. positive regulation of transcription, DNA-templated Source: MGI
    6. positive regulation of transcription from RNA polymerase II promoter by glucose Source: BHF-UCL
    7. response to hypoxia Source: Ensembl
    8. response to UV Source: BHF-UCL

    Keywords - Biological processi

    Transcription, Transcription regulation

    Keywords - Ligandi

    DNA-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Upstream stimulatory factor 1
    Alternative name(s):
    Major late transcription factor 1
    Gene namesi
    Name:Usf1
    Synonyms:Usf
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 1

    Organism-specific databases

    MGIiMGI:99542. Usf1.

    Subcellular locationi

    GO - Cellular componenti

    1. nucleus Source: UniProtKB-SubCell
    2. transcription factor complex Source: MGI

    Keywords - Cellular componenti

    Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 310310Upstream stimulatory factor 1PRO_0000127497Add
    BLAST

    Proteomic databases

    MaxQBiQ61069.
    PaxDbiQ61069.
    PRIDEiQ61069.

    PTM databases

    PhosphoSiteiQ61069.

    Expressioni

    Gene expression databases

    BgeeiQ61069.
    CleanExiMM_USF1.
    GenevestigatoriQ61069.

    Interactioni

    Subunit structurei

    Efficient DNA binding requires dimerization with another bHLH protein. Binds DNA as a homodimer or a heterodimer (USF1/USF2).

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    Stat1P422252EBI-2325635,EBI-647118

    Protein-protein interaction databases

    BioGridi204464. 5 interactions.
    IntActiQ61069. 1 interaction.
    STRINGi10090.ENSMUSP00000001284.

    Structurei

    3D structure databases

    ProteinModelPortaliQ61069.
    SMRiQ61069. Positions 197-300.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini199 – 25456bHLHPROSITE-ProRule annotationAdd
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni271 – 29222Leucine-zipperAdd
    BLAST

    Sequence similaritiesi

    Contains 1 bHLH (basic helix-loop-helix) domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiNOG272240.
    GeneTreeiENSGT00390000004498.
    HOVERGENiHBG004346.
    InParanoidiQ61069.
    KOiK09106.
    OMAiATETHYT.
    OrthoDBiEOG7GXPBW.
    PhylomeDBiQ61069.
    TreeFamiTF323338.

    Family and domain databases

    Gene3Di4.10.280.10. 1 hit.
    InterProiIPR011598. bHLH_dom.
    [Graphical view]
    PfamiPF00010. HLH. 1 hit.
    [Graphical view]
    SMARTiSM00353. HLH. 1 hit.
    [Graphical view]
    SUPFAMiSSF47459. SSF47459. 1 hit.
    PROSITEiPS50888. BHLH. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q61069-1 [UniParc]FASTAAdd to Basket

    « Hide

    MKGQQKTAET EEGTVQIQEG AVATGEDPTS VAIASIQSAA TFPDPNVKYV    50
    FRTENGGQVM YRVIQVSEGQ LDGQTEGSGA ISGYPATQSM TQAVIQGAFT 100
    SDDAVDTEGA AAETHYTYFP STAVGDGSGG TTSGSTTAVV TTQGSEALLG 150
    QATPPSTGQF FVMMSPQEVL QGGSQRSIAP RTHPYSPKSE APRTTRDEKR 200
    RAQHNEVERR RRDKINNWIV QLSKIIPDCS MESTKSGQSK GGILSKACDY 250
    IQELRQSNHR LSEELQGLDQ LQLDNDVLRQ QVEDLKNKNL LLRAQLRHHG 300
    LEVVIKNDSN 310
    Length:310
    Mass (Da):33,570
    Last modified:November 1, 1996 - v1
    Checksum:i7D0AF808A2FDFA1C
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U41741 Genomic DNA. Translation: AAC52921.1.
    CCDSiCCDS15495.1.
    RefSeqiNP_033506.1. NM_009480.2.
    XP_006496810.1. XM_006496747.1.
    XP_006496811.1. XM_006496748.1.
    UniGeneiMm.8.

    Genome annotation databases

    EnsembliENSMUST00000161241; ENSMUSP00000125729; ENSMUSG00000026641.
    ENSMUST00000167546; ENSMUSP00000128913; ENSMUSG00000026641.
    GeneIDi22278.
    KEGGimmu:22278.
    UCSCiuc007doj.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U41741 Genomic DNA. Translation: AAC52921.1 .
    CCDSi CCDS15495.1.
    RefSeqi NP_033506.1. NM_009480.2.
    XP_006496810.1. XM_006496747.1.
    XP_006496811.1. XM_006496748.1.
    UniGenei Mm.8.

    3D structure databases

    ProteinModelPortali Q61069.
    SMRi Q61069. Positions 197-300.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 204464. 5 interactions.
    IntActi Q61069. 1 interaction.
    STRINGi 10090.ENSMUSP00000001284.

    PTM databases

    PhosphoSitei Q61069.

    Proteomic databases

    MaxQBi Q61069.
    PaxDbi Q61069.
    PRIDEi Q61069.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000161241 ; ENSMUSP00000125729 ; ENSMUSG00000026641 .
    ENSMUST00000167546 ; ENSMUSP00000128913 ; ENSMUSG00000026641 .
    GeneIDi 22278.
    KEGGi mmu:22278.
    UCSCi uc007doj.1. mouse.

    Organism-specific databases

    CTDi 7391.
    MGIi MGI:99542. Usf1.

    Phylogenomic databases

    eggNOGi NOG272240.
    GeneTreei ENSGT00390000004498.
    HOVERGENi HBG004346.
    InParanoidi Q61069.
    KOi K09106.
    OMAi ATETHYT.
    OrthoDBi EOG7GXPBW.
    PhylomeDBi Q61069.
    TreeFami TF323338.

    Miscellaneous databases

    NextBioi 302403.
    PROi Q61069.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q61069.
    CleanExi MM_USF1.
    Genevestigatori Q61069.

    Family and domain databases

    Gene3Di 4.10.280.10. 1 hit.
    InterProi IPR011598. bHLH_dom.
    [Graphical view ]
    Pfami PF00010. HLH. 1 hit.
    [Graphical view ]
    SMARTi SM00353. HLH. 1 hit.
    [Graphical view ]
    SUPFAMi SSF47459. SSF47459. 1 hit.
    PROSITEi PS50888. BHLH. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Complete sequencing of the murine USF gene and comparison of its genomic organization to that of mFIP/USF2."
      Aperlo C., Boulukos K.E., Sage J., Cuzin F., Pognonec P.
      Genomics 37:337-344(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: C57BL/6.

    Entry informationi

    Entry nameiUSF1_MOUSE
    AccessioniPrimary (citable) accession number: Q61069
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1997
    Last sequence update: November 1, 1996
    Last modified: October 1, 2014
    This is version 103 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3