Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

Q61069 (USF1_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 102. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Interactions·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Upstream stimulatory factor 1
Alternative name(s):
Major late transcription factor 1
Gene names
Name:Usf1
Synonyms:Usf
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length310 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Transcription factor that binds to a symmetrical DNA sequence (E-boxes) (5'-CACGTG-3') that is found in a variety of viral and cellular promoters.

Subunit structure

Efficient DNA binding requires dimerization with another bHLH protein. Binds DNA as a homodimer or a heterodimer (USF1/USF2).

Subcellular location

Nucleus.

Sequence similarities

Contains 1 bHLH (basic helix-loop-helix) domain.

Ontologies

Keywords
   Biological processTranscription
Transcription regulation
   Cellular componentNucleus
   LigandDNA-binding
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processcellular response to insulin stimulus

Inferred from electronic annotation. Source: Ensembl

glucose metabolic process

Inferred from electronic annotation. Source: Ensembl

late viral transcription

Inferred from electronic annotation. Source: Ensembl

lipid homeostasis

Inferred from mutant phenotype PubMed 9890958. Source: BHF-UCL

positive regulation of transcription from RNA polymerase II promoter by glucose

Inferred from mutant phenotype PubMed 9890958. Source: BHF-UCL

positive regulation of transcription, DNA-templated

Inferred from direct assay PubMed 15466854. Source: MGI

response to UV

Inferred from mutant phenotype PubMed 15358786. Source: BHF-UCL

response to hypoxia

Inferred from electronic annotation. Source: Ensembl

   Cellular_componentnucleus

Inferred from electronic annotation. Source: UniProtKB-SubCell

transcription factor complex

Inferred by curator PubMed 15466854. Source: MGI

   Molecular_functionDNA binding

Inferred from direct assay PubMed 15466854. Source: MGI

RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity

Inferred from electronic annotation. Source: Ensembl

double-stranded DNA binding

Inferred from electronic annotation. Source: Ensembl

protein binding

Inferred from physical interaction PubMed 23749757. Source: IntAct

sequence-specific DNA binding

Inferred from electronic annotation. Source: Ensembl

sequence-specific DNA binding transcription factor activity

Inferred from direct assay PubMed 15466854. Source: MGI

Complete GO annotation...

Binary interactions

With

Entry

#Exp.

IntAct

Notes

Stat1P422252EBI-2325635,EBI-647118

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 310310Upstream stimulatory factor 1
PRO_0000127497

Regions

Domain199 – 25456bHLH
Region271 – 29222Leucine-zipper

Sequences

Sequence LengthMass (Da)Tools
Q61069 [UniParc].

Last modified November 1, 1996. Version 1.
Checksum: 7D0AF808A2FDFA1C

FASTA31033,570
        10         20         30         40         50         60 
MKGQQKTAET EEGTVQIQEG AVATGEDPTS VAIASIQSAA TFPDPNVKYV FRTENGGQVM 

        70         80         90        100        110        120 
YRVIQVSEGQ LDGQTEGSGA ISGYPATQSM TQAVIQGAFT SDDAVDTEGA AAETHYTYFP 

       130        140        150        160        170        180 
STAVGDGSGG TTSGSTTAVV TTQGSEALLG QATPPSTGQF FVMMSPQEVL QGGSQRSIAP 

       190        200        210        220        230        240 
RTHPYSPKSE APRTTRDEKR RAQHNEVERR RRDKINNWIV QLSKIIPDCS MESTKSGQSK 

       250        260        270        280        290        300 
GGILSKACDY IQELRQSNHR LSEELQGLDQ LQLDNDVLRQ QVEDLKNKNL LLRAQLRHHG 

       310 
LEVVIKNDSN 

« Hide

References

[1]"Complete sequencing of the murine USF gene and comparison of its genomic organization to that of mFIP/USF2."
Aperlo C., Boulukos K.E., Sage J., Cuzin F., Pognonec P.
Genomics 37:337-344(1996) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: C57BL/6.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
U41741 Genomic DNA. Translation: AAC52921.1.
CCDSCCDS15495.1.
RefSeqNP_033506.1. NM_009480.2.
XP_006496810.1. XM_006496747.1.
XP_006496811.1. XM_006496748.1.
UniGeneMm.8.

3D structure databases

ProteinModelPortalQ61069.
SMRQ61069. Positions 197-300.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid204464. 5 interactions.
IntActQ61069. 1 interaction.
STRING10090.ENSMUSP00000001284.

PTM databases

PhosphoSiteQ61069.

Proteomic databases

MaxQBQ61069.
PaxDbQ61069.
PRIDEQ61069.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000161241; ENSMUSP00000125729; ENSMUSG00000026641.
ENSMUST00000167546; ENSMUSP00000128913; ENSMUSG00000026641.
GeneID22278.
KEGGmmu:22278.
UCSCuc007doj.1. mouse.

Organism-specific databases

CTD7391.
MGIMGI:99542. Usf1.

Phylogenomic databases

eggNOGNOG272240.
GeneTreeENSGT00390000004498.
HOVERGENHBG004346.
InParanoidQ61069.
KOK09106.
OMAATETHYT.
OrthoDBEOG7GXPBW.
PhylomeDBQ61069.
TreeFamTF323338.

Gene expression databases

BgeeQ61069.
CleanExMM_USF1.
GenevestigatorQ61069.

Family and domain databases

Gene3D4.10.280.10. 1 hit.
InterProIPR011598. bHLH_dom.
[Graphical view]
PfamPF00010. HLH. 1 hit.
[Graphical view]
SMARTSM00353. HLH. 1 hit.
[Graphical view]
SUPFAMSSF47459. SSF47459. 1 hit.
PROSITEPS50888. BHLH. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio302403.
PROQ61069.
SOURCESearch...

Entry information

Entry nameUSF1_MOUSE
AccessionPrimary (citable) accession number: Q61069
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1996
Last modified: July 9, 2014
This is version 102 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot