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Reviewed, UniProtKB/Swiss-Prot Q61062 (DVL3_MOUSE)

Last modified February 9, 2010. Version 78. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Binary interactions · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

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Names and origin

Protein namesRecommended name:
    Segment polarity protein dishevelled homolog DVL-3
      Short name=Dishevelled-3
Alternative name(s):
    DSH homolog 3
Gene names
Name: Dvl3
OrganismMus musculus (Mouse)
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus

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Protein attributes

Sequence length716 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level.

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General annotation (Comments)

Function

May play a role in the signal transduction pathway mediated by multiple Wnt genes.

Subunit structure

Interacts through its PDZ domain with the C-terminal regions of VANGL1 and VANGL2. Ref.2

Subcellular location

Cytoplasm By similarity.

Tissue specificity

Ubiquitous.

Sequence similarities

Belongs to the DSH family.

Contains 1 DEP domain.

Contains 1 DIX domain.

Contains 1 PDZ (DHR) domain.

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Ontologies

Keywords
   Biological processWnt signaling pathway
   Cellular componentCytoplasm
   Molecular functionDevelopmental protein
   PTMPhosphoprotein
Gene Ontology (GO)
   Biological processWnt receptor signaling pathway

Inferred from electronic annotation. Source: UniProtKB-KW

intracellular signaling cascade

Inferred from electronic annotation. Source: InterPro

multicellular organismal development

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular functionsignal transducer activity

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

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Binary interactions

With

Entry

#Exp.

IntAct

Notes

Vangl1Q80Z961EBI-1538450,EBI-1750708
Vangl2Q91ZD41EBI-1538450,EBI-1750744

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Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 716716Segment polarity protein dishevelled homolog DVL-3
PRO_0000145750

Regions

Domain1 – 8282DIX
Domain249 – 32173PDZ
Domain422 – 49675DEP

Amino acid modifications

Modified residue3461Phosphothreonine By similarity

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Sequences

Sequence LengthMass (Da)Tools
Q61062-1 [UniParc].

Last modified November 1, 1996. Version 1.
Checksum: 55412C03202301F0

FASTA71678,123
        10         20         30         40         50         60 
MGETKIIYHL DGQETPYLVK LPLPAERVTL ADFKGVLQRP SYKFFFKSMD DDFGVVKEEI 

        70         80         90        100        110        120 
SDDNAKLPCF NGRVVSWLVS AEGSHPEPAP FCADNPSELP PSMERTGGIG DSRPPSFHPH 

       130        140        150        160        170        180 
ASGGSQENLD NDTETDSLVS AQRERPRRRD GPEHAARLNG TTKGERRREP GGYDSSSTLM 

       190        200        210        220        230        240 
SSELETTSFF DSDEDDSTSR FSSSTEQSSA SRLMRRHKRR RRKQKVSRIE RSSSFSSITD 

       250        260        270        280        290        300 
STMSLNIITV TLNMEKYNFL GISIVGQSNE RGDGGIYIGS IMKGGAVAAD GRIEPGDMLL 

       310        320        330        340        350        360 
QVNEINFENM SNDDAVRVLR EIVHKPGPIT LTVAKCWDPS PRGCFTLPRS EPIRPIDPAA 

       370        380        390        400        410        420 
WVSHTAAMTG TFPAYGMSPS LSTITSTSSS ITSSIPDTER LDDFHLSIHS DMAAIVKAMA 

       430        440        450        460        470        480 
SPESGLEVRD RMWLKITIPN AFIGSDVVDW LYHNVEGFTE RREARKYASN LLKAGFIRHT 

       490        500        510        520        530        540 
VNKITFSEQC YYIFGDLCGN MANLSLHDHD GSSGASDQDT LAPLPHPGAA PWPMAFPYQY 

       550        560        570        580        590        600 
PPPPHPYNPH PGFPELGYSY GGGSASSQHS EGSRSSGSNR SGSDRRKEKD PKAGDSKSGG 

       610        620        630        640        650        660 
SGSESDHTTR SSLRGPRERA PSERSGPAAS EHSHRSHHSL TSSLRSHHTH PSYGPPGVPP 

       670        680        690        700        710 
LYGPPMLMMT PPPGAMGPPG APPGRDLASV PPELTASRQS FRMAMGNPSE FFVDVM

« Hide

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References

[1]"Isolation and characterization of mouse dishevelled-3."
Tsang M., Lijam N., Yang Y., Beier D.R., Wynshaw-Boris A., Sussman D.J.
Dev. Dyn. 207:253-262(1996) [PubMed: 8922524] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Strain: BALB/c.
Tissue: Brain.
[2]"Independent mutations in mouse Vangl2 that cause neural tube defects in looptail mice impair interaction with members of the Dishevelled family."
Torban E., Wang H.-J., Groulx N., Gros P.
J. Biol. Chem. 279:52703-52713(2004) [PubMed: 15456783] [Abstract]
Cited for: INTERACTION WITH VANGL1 AND VANGL2.
+Additional computationally mapped references.

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Cross-references

Sequence databases

EMBL
GenBank
DDBJ		U41285 mRNA. Translation: AAB01761.1.
IPIIPI00117059.
UniGeneMm.247259
Mm.272443

3D structure databases

SMRQ61062. Positions 2-80, 247-335, 406-496.
ModBaseSearch...

Protein-protein interaction databases

IntActQ61062. 5 interactions.
STRINGQ61062.

PTM databases

PhosphoSiteQ61062.

Proteomic databases

PRIDEQ61062.

Genome annotation databases

EnsemblENSMUST00000003318; ENSMUSP00000003318; ENSMUSG00000003233; Mus musculus. [Genome view]
UCSCuc007ypw.1. mouse.

Organism-specific databases

MGIMGI:108100. Dvl3.

Phylogenomic databases

eggNOGroNOG10726.
HOGENOMHBG717800.
HOVERGENQ61062.
InParanoidQ61062.

Gene expression databases

ArrayExpressQ61062.
BgeeQ61062.
CleanExMM_DVL3.
GenevestigatorQ61062.
GermOnlineENSMUSG00000003233. Mus musculus.

Family and domain databases

InterProIPR000591. DEP_dom.
IPR008339. Dishevell.
IPR003351. Dishevelled.
IPR008342. Dishevelled_3_C.
IPR001158. DIX.
IPR015506. Dsh.
IPR001478. PDZ/DHR/GLGF.
IPR011991. WHTH_trsnscrt_rep_DNA-bd.
[Graphical view]
Gene3DG3DSA:1.10.10.10. Wing_hlx_DNA_bd. 1 hit.
PANTHERPTHR10878. Dsh. 1 hit.
PfamPF00610. DEP. 1 hit.
PF02377. Dishevelled. 1 hit.
PF00778. DIX. 1 hit.
PF00595. PDZ. 1 hit.
[Graphical view]
PRINTSPR01760. DISHEVELLED.
PR01763. DISHEVELLED3.
SMARTSM00021. DAX. 1 hit.
SM00049. DEP. 1 hit.
SM00228. PDZ. 1 hit.
[Graphical view]
PROSITEPS50186. DEP. 1 hit.
PS50841. DIX. 1 hit.
PS50106. PDZ. 1 hit.
[Graphical view]
ProtoNetSearch...

Other Resources

SOURCESearch...

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Entry information

Entry nameDVL3_MOUSE
AccessionPrimary (citable) accession number: Q61062
Entry history
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: November 1, 1996
Last modified: February 9, 2010
This is version 78 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHPI (Human Proteome Initiative)

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Relevant documents

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Binary interactions · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents