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Q61062

- DVL3_MOUSE

UniProt

Q61062 - DVL3_MOUSE

Protein

Segment polarity protein dishevelled homolog DVL-3

Gene

Dvl3

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 118 (01 Oct 2014)
      Sequence version 2 (03 Oct 2012)
      Previous versions | rss
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    Functioni

    May play a role in the signal transduction pathway mediated by multiple Wnt genes.

    GO - Molecular functioni

    1. beta-catenin binding Source: RefGenome
    2. frizzled binding Source: RefGenome
    3. protein binding Source: IntAct
    4. signal transducer activity Source: InterPro

    GO - Biological processi

    1. canonical Wnt signaling pathway Source: BHF-UCL
    2. cochlea morphogenesis Source: MGI
    3. convergent extension Source: RefGenome
    4. heart morphogenesis Source: MGI
    5. intracellular signal transduction Source: InterPro
    6. non-canonical Wnt signaling pathway via JNK cascade Source: BHF-UCL
    7. outflow tract septum morphogenesis Source: MGI
    8. planar cell polarity pathway involved in neural tube closure Source: MGI
    9. positive regulation of JUN kinase activity Source: Ensembl
    10. positive regulation of transcription, DNA-templated Source: RefGenome
    11. regulation of signaling Source: RefGenome
    12. response to drug Source: Ensembl
    13. Wnt signaling pathway, planar cell polarity pathway Source: BHF-UCL

    Keywords - Molecular functioni

    Developmental protein

    Keywords - Biological processi

    Wnt signaling pathway

    Enzyme and pathway databases

    ReactomeiREACT_216784. disassembly of the destruction complex and recruitment of AXIN to the membrane.
    REACT_225118. WNT mediated activation of DVL.
    REACT_227429. degradation of DVL.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Segment polarity protein dishevelled homolog DVL-3
    Short name:
    Dishevelled-3
    Alternative name(s):
    DSH homolog 3
    Gene namesi
    Name:Dvl3
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 16

    Organism-specific databases

    MGIiMGI:108100. Dvl3.

    Subcellular locationi

    Cytoplasm By similarity

    GO - Cellular componenti

    1. cell cortex Source: RefGenome
    2. cytoplasm Source: MGI

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 716716Segment polarity protein dishevelled homolog DVL-3PRO_0000145750Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei27 – 271Omega-N-methylarginineBy similarity
    Modified residuei48 – 481PhosphoserineBy similarity
    Modified residuei192 – 1921PhosphoserineBy similarity
    Modified residuei212 – 2121Omega-N-methylarginineBy similarity
    Modified residuei271 – 2711Asymmetric dimethylarginine; by PRMT1; alternateBy similarity
    Modified residuei271 – 2711Symmetric dimethylarginine; by PRMT7; alternateBy similarity
    Modified residuei342 – 3421Omega-N-methylarginine; alternateBy similarity
    Modified residuei342 – 3421Symmetric dimethylarginine; by PRMT7; alternateBy similarity
    Modified residuei346 – 3461PhosphothreonineBy similarity
    Modified residuei614 – 6141Symmetric dimethylarginine; by PRMT7By similarity
    Modified residuei698 – 6981Dimethylated arginine; alternateBy similarity
    Modified residuei698 – 6981Omega-N-methylarginine; alternateBy similarity
    Modified residuei700 – 7001PhosphoserineBy similarity

    Post-translational modificationi

    Ubiquitinated. Deubiquitinated by CYLD, which acts on 'Lys-63'-linked ubiquitin chains By similarity.By similarity
    Phosphorylated by CSNK1D.By similarity
    Arginine methylation may function as a switch in regulation of function in Wnt signaling.By similarity

    Keywords - PTMi

    Methylation, Phosphoprotein, Ubl conjugation

    Proteomic databases

    PaxDbiQ61062.
    PRIDEiQ61062.

    PTM databases

    PhosphoSiteiQ61062.

    Expressioni

    Tissue specificityi

    Ubiquitous.

    Gene expression databases

    CleanExiMM_DVL3.
    GenevestigatoriQ61062.

    Interactioni

    Subunit structurei

    Interacts (via the PDZ domain) with the C-terminal regions of VANGL1 and VANGL2. Interacts (via the region containing both the PDZ and DEP domains) with LRRFIP2; the DIX domain may inhibit this interaction. Interacts with CYLD. Interacts with CEP164 and DAB2.2 Publications

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    Axin1O356252EBI-1538450,EBI-2365912
    Dvl2Q608383EBI-1538450,EBI-641940
    Vangl1Q80Z962EBI-1538450,EBI-1750708
    Vangl2Q91ZD42EBI-1538450,EBI-1750744

    Protein-protein interaction databases

    IntActiQ61062. 15 interactions.
    MINTiMINT-8384231.
    STRINGi10090.ENSMUSP00000003318.

    Structurei

    3D structure databases

    ProteinModelPortaliQ61062.
    SMRiQ61062. Positions 3-79, 247-335, 411-499.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini1 – 8282DIXPROSITE-ProRule annotationAdd
    BLAST
    Domaini249 – 32173PDZPROSITE-ProRule annotationAdd
    BLAST
    Domaini422 – 49675DEPPROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Belongs to the DSH family.Curated
    Contains 1 DEP domain.PROSITE-ProRule annotation
    Contains 1 DIX domain.PROSITE-ProRule annotation
    Contains 1 PDZ (DHR) domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiNOG322275.
    GeneTreeiENSGT00390000013552.
    HOGENOMiHOG000017084.
    HOVERGENiHBG005542.
    InParanoidiQ61062.
    KOiK02353.
    OrthoDBiEOG7BP82N.
    TreeFamiTF318198.

    Family and domain databases

    Gene3Di1.10.10.10. 1 hit.
    2.30.42.10. 1 hit.
    InterProiIPR000591. DEP_dom.
    IPR008342. Dishevelled_3.
    IPR024580. Dishevelled_C-dom.
    IPR008339. Dishevelled_fam.
    IPR003351. Dishevelled_protein_dom.
    IPR001158. DIX.
    IPR015506. Dsh/Dvl-rel.
    IPR001478. PDZ.
    IPR029071. Ubiquitin-rel_dom.
    IPR011991. WHTH_DNA-bd_dom.
    [Graphical view]
    PANTHERiPTHR10878. PTHR10878. 1 hit.
    PTHR10878:SF6. PTHR10878:SF6. 1 hit.
    PfamiPF00610. DEP. 1 hit.
    PF02377. Dishevelled. 1 hit.
    PF00778. DIX. 1 hit.
    PF12316. Dsh_C. 1 hit.
    PF00595. PDZ. 1 hit.
    [Graphical view]
    PRINTSiPR01760. DISHEVELLED.
    PR01763. DISHEVELLED3.
    SMARTiSM00021. DAX. 1 hit.
    SM00049. DEP. 1 hit.
    SM00228. PDZ. 1 hit.
    [Graphical view]
    SUPFAMiSSF50156. SSF50156. 1 hit.
    SSF54236. SSF54236. 1 hit.
    PROSITEiPS50186. DEP. 1 hit.
    PS50841. DIX. 1 hit.
    PS50106. PDZ. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q61062-1 [UniParc]FASTAAdd to Basket

    « Hide

    MGETKIIYHL DGQETPYLVK LPLPAERVTL ADFKGVLQRP SYKFFFKSMD    50
    DDFGVVKEEI SDDNAKLPCF NGRVVSWLVS AEGSHPEPAP FCADNPSELP 100
    PSMERTGGIG DSRPPSFHPH ASGGSQENLD NDTETDSLVS AQRERPRRRD 150
    GPEHAARLNG TTKGERRREP GGYDSSSTLM SSELETTSFF DSDEDDSTSR 200
    FSSSTEQSSA SRLMRRHKRR RRKQKVSRIE RSSSFSSITD STMSLNIITV 250
    TLNMEKYNFL GISIVGQSNE RGDGGIYIGS IMKGGAVAAD GRIEPGDMLL 300
    QVNEINFENM SNDDAVRVLR EIVHKPGPIT LTVAKCWDPS PRGCFTLPRS 350
    EPIRPIDPAA WVSHTAAMTG TFPAYGMSPS LSTITSTSSS ITSSIPDTER 400
    LDDFHLSIHS DMAAIVKAMA SPESGLEVRD RMWLKITIPN AFIGSDVVDW 450
    LYHNVEGFTD RREARKYASN LLKAGFIRHT VNKITFSEQC YYIFGDLCGN 500
    MANLSLHDHD GSSGASDQDT LAPLPHPGAA PWPMAFPYQY PPPPHPYNPH 550
    PGFPELGYSY GGGSASSQHS EGSRSSGSNR SGSDRRKEKD PKAGDSKSGG 600
    SGSESDHTTR SSLRGPRERA PSERSGPAAS EHSHRSHHSL TSSLRSHHTH 650
    PSYGPPGVPP LYGPPMLMMT PPPAAMGPPG APPGRDLASV PPELTASRQS 700
    FRMAMGNPSE FFVDVM 716
    Length:716
    Mass (Da):78,123
    Last modified:October 3, 2012 - v2
    Checksum:i552A5BE4BEA801F0
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti460 – 4601D → E in AAB01761. (PubMed:8922524)Curated
    Sequence conflicti674 – 6741A → G in AAB01761. (PubMed:8922524)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U41285 mRNA. Translation: AAB01761.1.
    AC087898 Genomic DNA. No translation available.
    CH466521 Genomic DNA. Translation: EDK97570.1.
    CCDSiCCDS37287.1.
    RefSeqiNP_031915.2. NM_007889.2.
    UniGeneiMm.247259.
    Mm.272443.

    Genome annotation databases

    EnsembliENSMUST00000003318; ENSMUSP00000003318; ENSMUSG00000003233.
    GeneIDi13544.
    KEGGimmu:13544.
    UCSCiuc007ypw.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U41285 mRNA. Translation: AAB01761.1 .
    AC087898 Genomic DNA. No translation available.
    CH466521 Genomic DNA. Translation: EDK97570.1 .
    CCDSi CCDS37287.1.
    RefSeqi NP_031915.2. NM_007889.2.
    UniGenei Mm.247259.
    Mm.272443.

    3D structure databases

    ProteinModelPortali Q61062.
    SMRi Q61062. Positions 3-79, 247-335, 411-499.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    IntActi Q61062. 15 interactions.
    MINTi MINT-8384231.
    STRINGi 10090.ENSMUSP00000003318.

    PTM databases

    PhosphoSitei Q61062.

    Proteomic databases

    PaxDbi Q61062.
    PRIDEi Q61062.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000003318 ; ENSMUSP00000003318 ; ENSMUSG00000003233 .
    GeneIDi 13544.
    KEGGi mmu:13544.
    UCSCi uc007ypw.1. mouse.

    Organism-specific databases

    CTDi 1857.
    MGIi MGI:108100. Dvl3.

    Phylogenomic databases

    eggNOGi NOG322275.
    GeneTreei ENSGT00390000013552.
    HOGENOMi HOG000017084.
    HOVERGENi HBG005542.
    InParanoidi Q61062.
    KOi K02353.
    OrthoDBi EOG7BP82N.
    TreeFami TF318198.

    Enzyme and pathway databases

    Reactomei REACT_216784. disassembly of the destruction complex and recruitment of AXIN to the membrane.
    REACT_225118. WNT mediated activation of DVL.
    REACT_227429. degradation of DVL.

    Miscellaneous databases

    NextBioi 284150.
    PROi Q61062.
    SOURCEi Search...

    Gene expression databases

    CleanExi MM_DVL3.
    Genevestigatori Q61062.

    Family and domain databases

    Gene3Di 1.10.10.10. 1 hit.
    2.30.42.10. 1 hit.
    InterProi IPR000591. DEP_dom.
    IPR008342. Dishevelled_3.
    IPR024580. Dishevelled_C-dom.
    IPR008339. Dishevelled_fam.
    IPR003351. Dishevelled_protein_dom.
    IPR001158. DIX.
    IPR015506. Dsh/Dvl-rel.
    IPR001478. PDZ.
    IPR029071. Ubiquitin-rel_dom.
    IPR011991. WHTH_DNA-bd_dom.
    [Graphical view ]
    PANTHERi PTHR10878. PTHR10878. 1 hit.
    PTHR10878:SF6. PTHR10878:SF6. 1 hit.
    Pfami PF00610. DEP. 1 hit.
    PF02377. Dishevelled. 1 hit.
    PF00778. DIX. 1 hit.
    PF12316. Dsh_C. 1 hit.
    PF00595. PDZ. 1 hit.
    [Graphical view ]
    PRINTSi PR01760. DISHEVELLED.
    PR01763. DISHEVELLED3.
    SMARTi SM00021. DAX. 1 hit.
    SM00049. DEP. 1 hit.
    SM00228. PDZ. 1 hit.
    [Graphical view ]
    SUPFAMi SSF50156. SSF50156. 1 hit.
    SSF54236. SSF54236. 1 hit.
    PROSITEi PS50186. DEP. 1 hit.
    PS50841. DIX. 1 hit.
    PS50106. PDZ. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Isolation and characterization of mouse dishevelled-3."
      Tsang M., Lijam N., Yang Y., Beier D.R., Wynshaw-Boris A., Sussman D.J.
      Dev. Dyn. 207:253-262(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: BALB/c.
      Tissue: Brain.
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: C57BL/6J.
    3. Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
      Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. "Regulation of the Wnt signaling pathway by disabled-2 (Dab2)."
      Howe P.H.
      EMBO J. 22:3084-3094(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH DAB2.
    5. "Independent mutations in mouse Vangl2 that cause neural tube defects in looptail mice impair interaction with members of the Dishevelled family."
      Torban E., Wang H.-J., Groulx N., Gros P.
      J. Biol. Chem. 279:52703-52713(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH VANGL1 AND VANGL2.

    Entry informationi

    Entry nameiDVL3_MOUSE
    AccessioniPrimary (citable) accession number: Q61062
    Secondary accession number(s): G5E820
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 30, 2000
    Last sequence update: October 3, 2012
    Last modified: October 1, 2014
    This is version 118 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3