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Q61062 (DVL3_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 116. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Interactions·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Segment polarity protein dishevelled homolog DVL-3

Short name=Dishevelled-3
Alternative name(s):
DSH homolog 3
Gene names
Name:Dvl3
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length716 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

May play a role in the signal transduction pathway mediated by multiple Wnt genes.

Subunit structure

Interacts (via the PDZ domain) with the C-terminal regions of VANGL1 and VANGL2. Interacts (via the region containing both the PDZ and DEP domains) with LRRFIP2; the DIX domain may inhibit this interaction. Interacts with CYLD. Interacts with CEP164 and DAB2. Ref.4 Ref.5

Subcellular location

Cytoplasm By similarity.

Tissue specificity

Ubiquitous.

Post-translational modification

Ubiquitinated. Deubiquitinated by CYLD, which acts on 'Lys-63'-linked ubiquitin chains By similarity.

Phosphorylated by CSNK1D By similarity.

Arginine methylation may function as a switch in regulation of function in Wnt signaling By similarity.

Sequence similarities

Belongs to the DSH family.

Contains 1 DEP domain.

Contains 1 DIX domain.

Contains 1 PDZ (DHR) domain.

Ontologies

Keywords
   Biological processWnt signaling pathway
   Cellular componentCytoplasm
   Molecular functionDevelopmental protein
   PTMMethylation
Phosphoprotein
Ubl conjugation
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processWnt signaling pathway, planar cell polarity pathway

Traceable author statement PubMed 11274398. Source: BHF-UCL

canonical Wnt signaling pathway

Traceable author statement PubMed 11274398. Source: BHF-UCL

cochlea morphogenesis

Inferred from genetic interaction PubMed 19008950. Source: MGI

convergent extension

Inferred from Biological aspect of Ancestor. Source: RefGenome

heart morphogenesis

Inferred from genetic interaction PubMed 19008950. Source: MGI

intracellular signal transduction

Inferred from electronic annotation. Source: InterPro

non-canonical Wnt signaling pathway via JNK cascade

Inferred from direct assay PubMed 11274398. Source: BHF-UCL

outflow tract septum morphogenesis

Inferred from mutant phenotype PubMed 19008950. Source: MGI

planar cell polarity pathway involved in neural tube closure

Inferred from genetic interaction PubMed 19008950. Source: MGI

positive regulation of JUN kinase activity

Inferred from electronic annotation. Source: Ensembl

positive regulation of transcription, DNA-templated

Inferred from Biological aspect of Ancestor. Source: RefGenome

regulation of signaling

Inferred from Biological aspect of Ancestor. Source: RefGenome

response to drug

Inferred from electronic annotation. Source: Ensembl

   Cellular_componentcell cortex

Inferred from Biological aspect of Ancestor. Source: RefGenome

cytoplasm

Inferred from direct assay PubMed 17005174. Source: MGI

   Molecular_functionbeta-catenin binding

Inferred from Biological aspect of Ancestor. Source: RefGenome

frizzled binding

Inferred from Biological aspect of Ancestor. Source: RefGenome

protein binding

Inferred from physical interaction Ref.4Ref.5PubMed 21092292. Source: IntAct

signal transducer activity

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 716716Segment polarity protein dishevelled homolog DVL-3
PRO_0000145750

Regions

Domain1 – 8282DIX
Domain249 – 32173PDZ
Domain422 – 49675DEP

Amino acid modifications

Modified residue271Omega-N-methylarginine By similarity
Modified residue481Phosphoserine By similarity
Modified residue1921Phosphoserine By similarity
Modified residue2121Omega-N-methylarginine By similarity
Modified residue2711Asymmetric dimethylarginine; by PRMT1; alternate By similarity
Modified residue2711Symmetric dimethylarginine; by PRMT7; alternate By similarity
Modified residue3421Omega-N-methylarginine; alternate By similarity
Modified residue3421Symmetric dimethylarginine; by PRMT7; alternate By similarity
Modified residue3461Phosphothreonine By similarity
Modified residue6141Symmetric dimethylarginine; by PRMT7 By similarity
Modified residue6981Dimethylated arginine; alternate By similarity
Modified residue6981Omega-N-methylarginine; alternate By similarity
Modified residue7001Phosphoserine By similarity

Experimental info

Sequence conflict4601D → E in AAB01761. Ref.1
Sequence conflict6741A → G in AAB01761. Ref.1

Sequences

Sequence LengthMass (Da)Tools
Q61062 [UniParc].

Last modified October 3, 2012. Version 2.
Checksum: 552A5BE4BEA801F0

FASTA71678,123
        10         20         30         40         50         60 
MGETKIIYHL DGQETPYLVK LPLPAERVTL ADFKGVLQRP SYKFFFKSMD DDFGVVKEEI 

        70         80         90        100        110        120 
SDDNAKLPCF NGRVVSWLVS AEGSHPEPAP FCADNPSELP PSMERTGGIG DSRPPSFHPH 

       130        140        150        160        170        180 
ASGGSQENLD NDTETDSLVS AQRERPRRRD GPEHAARLNG TTKGERRREP GGYDSSSTLM 

       190        200        210        220        230        240 
SSELETTSFF DSDEDDSTSR FSSSTEQSSA SRLMRRHKRR RRKQKVSRIE RSSSFSSITD 

       250        260        270        280        290        300 
STMSLNIITV TLNMEKYNFL GISIVGQSNE RGDGGIYIGS IMKGGAVAAD GRIEPGDMLL 

       310        320        330        340        350        360 
QVNEINFENM SNDDAVRVLR EIVHKPGPIT LTVAKCWDPS PRGCFTLPRS EPIRPIDPAA 

       370        380        390        400        410        420 
WVSHTAAMTG TFPAYGMSPS LSTITSTSSS ITSSIPDTER LDDFHLSIHS DMAAIVKAMA 

       430        440        450        460        470        480 
SPESGLEVRD RMWLKITIPN AFIGSDVVDW LYHNVEGFTD RREARKYASN LLKAGFIRHT 

       490        500        510        520        530        540 
VNKITFSEQC YYIFGDLCGN MANLSLHDHD GSSGASDQDT LAPLPHPGAA PWPMAFPYQY 

       550        560        570        580        590        600 
PPPPHPYNPH PGFPELGYSY GGGSASSQHS EGSRSSGSNR SGSDRRKEKD PKAGDSKSGG 

       610        620        630        640        650        660 
SGSESDHTTR SSLRGPRERA PSERSGPAAS EHSHRSHHSL TSSLRSHHTH PSYGPPGVPP 

       670        680        690        700        710 
LYGPPMLMMT PPPAAMGPPG APPGRDLASV PPELTASRQS FRMAMGNPSE FFVDVM 

« Hide

References

« Hide 'large scale' references
[1]"Isolation and characterization of mouse dishevelled-3."
Tsang M., Lijam N., Yang Y., Beier D.R., Wynshaw-Boris A., Sussman D.J.
Dev. Dyn. 207:253-262(1996) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Strain: BALB/c.
Tissue: Brain.
[2]"Lineage-specific biology revealed by a finished genome assembly of the mouse."
Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X., Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y., Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S. expand/collapse author list , Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R., Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K., Eichler E.E., Ponting C.P.
PLoS Biol. 7:E1000112-E1000112(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: C57BL/6J.
[3]Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]"Regulation of the Wnt signaling pathway by disabled-2 (Dab2)."
Howe P.H.
EMBO J. 22:3084-3094(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: INTERACTION WITH DAB2.
[5]"Independent mutations in mouse Vangl2 that cause neural tube defects in looptail mice impair interaction with members of the Dishevelled family."
Torban E., Wang H.-J., Groulx N., Gros P.
J. Biol. Chem. 279:52703-52713(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: INTERACTION WITH VANGL1 AND VANGL2.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
U41285 mRNA. Translation: AAB01761.1.
AC087898 Genomic DNA. No translation available.
CH466521 Genomic DNA. Translation: EDK97570.1.
CCDSCCDS37287.1.
RefSeqNP_031915.2. NM_007889.2.
UniGeneMm.247259.
Mm.272443.

3D structure databases

ProteinModelPortalQ61062.
SMRQ61062. Positions 3-79, 247-335, 411-499.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

IntActQ61062. 15 interactions.
MINTMINT-8384231.
STRING10090.ENSMUSP00000003318.

PTM databases

PhosphoSiteQ61062.

Proteomic databases

PaxDbQ61062.
PRIDEQ61062.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000003318; ENSMUSP00000003318; ENSMUSG00000003233.
GeneID13544.
KEGGmmu:13544.
UCSCuc007ypw.1. mouse.

Organism-specific databases

CTD1857.
MGIMGI:108100. Dvl3.

Phylogenomic databases

eggNOGNOG322275.
GeneTreeENSGT00390000013552.
HOGENOMHOG000017084.
HOVERGENHBG005542.
InParanoidQ61062.
KOK02353.
OrthoDBEOG7BP82N.
TreeFamTF318198.

Gene expression databases

CleanExMM_DVL3.
GenevestigatorQ61062.

Family and domain databases

Gene3D1.10.10.10. 1 hit.
2.30.42.10. 1 hit.
InterProIPR000591. DEP_dom.
IPR008342. Dishevelled_3.
IPR024580. Dishevelled_C-dom.
IPR008339. Dishevelled_fam.
IPR003351. Dishevelled_protein_dom.
IPR001158. DIX.
IPR015506. Dsh/Dvl-rel.
IPR001478. PDZ.
IPR029071. Ubiquitin-rel_dom.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PANTHERPTHR10878. PTHR10878. 1 hit.
PTHR10878:SF6. PTHR10878:SF6. 1 hit.
PfamPF00610. DEP. 1 hit.
PF02377. Dishevelled. 1 hit.
PF00778. DIX. 1 hit.
PF12316. Dsh_C. 1 hit.
PF00595. PDZ. 1 hit.
[Graphical view]
PRINTSPR01760. DISHEVELLED.
PR01763. DISHEVELLED3.
SMARTSM00021. DAX. 1 hit.
SM00049. DEP. 1 hit.
SM00228. PDZ. 1 hit.
[Graphical view]
SUPFAMSSF50156. SSF50156. 1 hit.
SSF54236. SSF54236. 1 hit.
PROSITEPS50186. DEP. 1 hit.
PS50841. DIX. 1 hit.
PS50106. PDZ. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio284150.
PROQ61062.
SOURCESearch...

Entry information

Entry nameDVL3_MOUSE
AccessionPrimary (citable) accession number: Q61062
Secondary accession number(s): G5E820
Entry history
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: October 3, 2012
Last modified: July 9, 2014
This is version 116 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot