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Q61062

- DVL3_MOUSE

UniProt

Q61062 - DVL3_MOUSE

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Protein

Segment polarity protein dishevelled homolog DVL-3

Gene

Dvl3

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

May play a role in the signal transduction pathway mediated by multiple Wnt genes.

GO - Molecular functioni

  1. beta-catenin binding Source: RefGenome
  2. frizzled binding Source: RefGenome

GO - Biological processi

  1. canonical Wnt signaling pathway Source: BHF-UCL
  2. cochlea morphogenesis Source: MGI
  3. convergent extension Source: RefGenome
  4. heart morphogenesis Source: MGI
  5. intracellular signal transduction Source: InterPro
  6. non-canonical Wnt signaling pathway via JNK cascade Source: BHF-UCL
  7. outflow tract septum morphogenesis Source: MGI
  8. planar cell polarity pathway involved in neural tube closure Source: MGI
  9. positive regulation of JUN kinase activity Source: Ensembl
  10. positive regulation of transcription, DNA-templated Source: RefGenome
  11. regulation of signaling Source: RefGenome
  12. response to drug Source: Ensembl
  13. Wnt signaling pathway, planar cell polarity pathway Source: BHF-UCL
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Keywords - Biological processi

Wnt signaling pathway

Enzyme and pathway databases

ReactomeiREACT_207044. TCF dependent signaling in response to WNT.
REACT_216784. disassembly of the destruction complex and recruitment of AXIN to the membrane.
REACT_225118. WNT mediated activation of DVL.
REACT_227429. degradation of DVL.
REACT_256730. negative regulation of TCF-dependent signaling by DVL-interacting proteins.

Names & Taxonomyi

Protein namesi
Recommended name:
Segment polarity protein dishevelled homolog DVL-3
Short name:
Dishevelled-3
Alternative name(s):
DSH homolog 3
Gene namesi
Name:Dvl3
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 16

Organism-specific databases

MGIiMGI:108100. Dvl3.

Subcellular locationi

Cytoplasm By similarity

GO - Cellular componenti

  1. cell cortex Source: RefGenome
  2. cytoplasm Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 716716Segment polarity protein dishevelled homolog DVL-3PRO_0000145750Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei27 – 271Omega-N-methylarginineBy similarity
Modified residuei48 – 481PhosphoserineBy similarity
Modified residuei192 – 1921PhosphoserineBy similarity
Modified residuei212 – 2121Omega-N-methylarginineBy similarity
Modified residuei271 – 2711Asymmetric dimethylarginine; by PRMT1; alternateBy similarity
Modified residuei271 – 2711Symmetric dimethylarginine; by PRMT7; alternateBy similarity
Modified residuei342 – 3421Omega-N-methylarginine; alternateBy similarity
Modified residuei342 – 3421Symmetric dimethylarginine; by PRMT7; alternateBy similarity
Modified residuei346 – 3461PhosphothreonineBy similarity
Modified residuei614 – 6141Symmetric dimethylarginine; by PRMT7By similarity
Modified residuei698 – 6981Dimethylated arginine; alternateBy similarity
Modified residuei698 – 6981Omega-N-methylarginine; alternateBy similarity
Modified residuei700 – 7001PhosphoserineBy similarity

Post-translational modificationi

Ubiquitinated. Deubiquitinated by CYLD, which acts on 'Lys-63'-linked ubiquitin chains (By similarity).By similarity
Phosphorylated by CSNK1D.By similarity
Arginine methylation may function as a switch in regulation of function in Wnt signaling.By similarity

Keywords - PTMi

Methylation, Phosphoprotein, Ubl conjugation

Proteomic databases

PaxDbiQ61062.
PRIDEiQ61062.

PTM databases

PhosphoSiteiQ61062.

Expressioni

Tissue specificityi

Ubiquitous.

Gene expression databases

CleanExiMM_DVL3.
ExpressionAtlasiQ61062. baseline.
GenevestigatoriQ61062.

Interactioni

Subunit structurei

Interacts (via the PDZ domain) with the C-terminal regions of VANGL1 and VANGL2. Interacts (via the region containing both the PDZ and DEP domains) with LRRFIP2; the DIX domain may inhibit this interaction. Interacts with CYLD. Interacts with CEP164 and DAB2.2 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
Axin1O356252EBI-1538450,EBI-2365912
Dvl2Q608383EBI-1538450,EBI-641940
Vangl1Q80Z962EBI-1538450,EBI-1750708
Vangl2Q91ZD42EBI-1538450,EBI-1750744

Protein-protein interaction databases

IntActiQ61062. 15 interactions.
MINTiMINT-8384231.
STRINGi10090.ENSMUSP00000003318.

Structurei

3D structure databases

ProteinModelPortaliQ61062.
SMRiQ61062. Positions 3-79, 247-335, 411-499.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini1 – 8282DIXPROSITE-ProRule annotationAdd
BLAST
Domaini249 – 32173PDZPROSITE-ProRule annotationAdd
BLAST
Domaini422 – 49675DEPPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the DSH family.Curated
Contains 1 DEP domain.PROSITE-ProRule annotation
Contains 1 DIX domain.PROSITE-ProRule annotation
Contains 1 PDZ (DHR) domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiNOG322275.
GeneTreeiENSGT00390000013552.
HOGENOMiHOG000017084.
HOVERGENiHBG005542.
InParanoidiQ61062.
KOiK02353.
OrthoDBiEOG7BP82N.
TreeFamiTF318198.

Family and domain databases

Gene3Di1.10.10.10. 1 hit.
2.30.42.10. 1 hit.
InterProiIPR000591. DEP_dom.
IPR024580. Dishevelled_C-dom.
IPR008339. Dishevelled_fam.
IPR003351. Dishevelled_protein_dom.
IPR001158. DIX.
IPR015506. Dsh/Dvl-rel.
IPR008342. DVL3.
IPR001478. PDZ.
IPR029071. Ubiquitin-rel_dom.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PANTHERiPTHR10878. PTHR10878. 1 hit.
PTHR10878:SF6. PTHR10878:SF6. 1 hit.
PfamiPF00610. DEP. 1 hit.
PF02377. Dishevelled. 1 hit.
PF00778. DIX. 1 hit.
PF12316. Dsh_C. 1 hit.
PF00595. PDZ. 1 hit.
[Graphical view]
PRINTSiPR01760. DISHEVELLED.
PR01763. DISHEVELLED3.
SMARTiSM00021. DAX. 1 hit.
SM00049. DEP. 1 hit.
SM00228. PDZ. 1 hit.
[Graphical view]
SUPFAMiSSF50156. SSF50156. 1 hit.
SSF54236. SSF54236. 1 hit.
PROSITEiPS50186. DEP. 1 hit.
PS50841. DIX. 1 hit.
PS50106. PDZ. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q61062-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MGETKIIYHL DGQETPYLVK LPLPAERVTL ADFKGVLQRP SYKFFFKSMD
60 70 80 90 100
DDFGVVKEEI SDDNAKLPCF NGRVVSWLVS AEGSHPEPAP FCADNPSELP
110 120 130 140 150
PSMERTGGIG DSRPPSFHPH ASGGSQENLD NDTETDSLVS AQRERPRRRD
160 170 180 190 200
GPEHAARLNG TTKGERRREP GGYDSSSTLM SSELETTSFF DSDEDDSTSR
210 220 230 240 250
FSSSTEQSSA SRLMRRHKRR RRKQKVSRIE RSSSFSSITD STMSLNIITV
260 270 280 290 300
TLNMEKYNFL GISIVGQSNE RGDGGIYIGS IMKGGAVAAD GRIEPGDMLL
310 320 330 340 350
QVNEINFENM SNDDAVRVLR EIVHKPGPIT LTVAKCWDPS PRGCFTLPRS
360 370 380 390 400
EPIRPIDPAA WVSHTAAMTG TFPAYGMSPS LSTITSTSSS ITSSIPDTER
410 420 430 440 450
LDDFHLSIHS DMAAIVKAMA SPESGLEVRD RMWLKITIPN AFIGSDVVDW
460 470 480 490 500
LYHNVEGFTD RREARKYASN LLKAGFIRHT VNKITFSEQC YYIFGDLCGN
510 520 530 540 550
MANLSLHDHD GSSGASDQDT LAPLPHPGAA PWPMAFPYQY PPPPHPYNPH
560 570 580 590 600
PGFPELGYSY GGGSASSQHS EGSRSSGSNR SGSDRRKEKD PKAGDSKSGG
610 620 630 640 650
SGSESDHTTR SSLRGPRERA PSERSGPAAS EHSHRSHHSL TSSLRSHHTH
660 670 680 690 700
PSYGPPGVPP LYGPPMLMMT PPPAAMGPPG APPGRDLASV PPELTASRQS
710
FRMAMGNPSE FFVDVM
Length:716
Mass (Da):78,123
Last modified:October 3, 2012 - v2
Checksum:i552A5BE4BEA801F0
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti460 – 4601D → E in AAB01761. (PubMed:8922524)Curated
Sequence conflicti674 – 6741A → G in AAB01761. (PubMed:8922524)Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U41285 mRNA. Translation: AAB01761.1.
AC087898 Genomic DNA. No translation available.
CH466521 Genomic DNA. Translation: EDK97570.1.
CCDSiCCDS37287.1.
RefSeqiNP_031915.2. NM_007889.2.
UniGeneiMm.247259.
Mm.272443.

Genome annotation databases

EnsembliENSMUST00000003318; ENSMUSP00000003318; ENSMUSG00000003233.
GeneIDi13544.
KEGGimmu:13544.
UCSCiuc007ypw.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U41285 mRNA. Translation: AAB01761.1 .
AC087898 Genomic DNA. No translation available.
CH466521 Genomic DNA. Translation: EDK97570.1 .
CCDSi CCDS37287.1.
RefSeqi NP_031915.2. NM_007889.2.
UniGenei Mm.247259.
Mm.272443.

3D structure databases

ProteinModelPortali Q61062.
SMRi Q61062. Positions 3-79, 247-335, 411-499.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

IntActi Q61062. 15 interactions.
MINTi MINT-8384231.
STRINGi 10090.ENSMUSP00000003318.

PTM databases

PhosphoSitei Q61062.

Proteomic databases

PaxDbi Q61062.
PRIDEi Q61062.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000003318 ; ENSMUSP00000003318 ; ENSMUSG00000003233 .
GeneIDi 13544.
KEGGi mmu:13544.
UCSCi uc007ypw.1. mouse.

Organism-specific databases

CTDi 1857.
MGIi MGI:108100. Dvl3.

Phylogenomic databases

eggNOGi NOG322275.
GeneTreei ENSGT00390000013552.
HOGENOMi HOG000017084.
HOVERGENi HBG005542.
InParanoidi Q61062.
KOi K02353.
OrthoDBi EOG7BP82N.
TreeFami TF318198.

Enzyme and pathway databases

Reactomei REACT_207044. TCF dependent signaling in response to WNT.
REACT_216784. disassembly of the destruction complex and recruitment of AXIN to the membrane.
REACT_225118. WNT mediated activation of DVL.
REACT_227429. degradation of DVL.
REACT_256730. negative regulation of TCF-dependent signaling by DVL-interacting proteins.

Miscellaneous databases

NextBioi 284150.
PROi Q61062.
SOURCEi Search...

Gene expression databases

CleanExi MM_DVL3.
ExpressionAtlasi Q61062. baseline.
Genevestigatori Q61062.

Family and domain databases

Gene3Di 1.10.10.10. 1 hit.
2.30.42.10. 1 hit.
InterProi IPR000591. DEP_dom.
IPR024580. Dishevelled_C-dom.
IPR008339. Dishevelled_fam.
IPR003351. Dishevelled_protein_dom.
IPR001158. DIX.
IPR015506. Dsh/Dvl-rel.
IPR008342. DVL3.
IPR001478. PDZ.
IPR029071. Ubiquitin-rel_dom.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view ]
PANTHERi PTHR10878. PTHR10878. 1 hit.
PTHR10878:SF6. PTHR10878:SF6. 1 hit.
Pfami PF00610. DEP. 1 hit.
PF02377. Dishevelled. 1 hit.
PF00778. DIX. 1 hit.
PF12316. Dsh_C. 1 hit.
PF00595. PDZ. 1 hit.
[Graphical view ]
PRINTSi PR01760. DISHEVELLED.
PR01763. DISHEVELLED3.
SMARTi SM00021. DAX. 1 hit.
SM00049. DEP. 1 hit.
SM00228. PDZ. 1 hit.
[Graphical view ]
SUPFAMi SSF50156. SSF50156. 1 hit.
SSF54236. SSF54236. 1 hit.
PROSITEi PS50186. DEP. 1 hit.
PS50841. DIX. 1 hit.
PS50106. PDZ. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Isolation and characterization of mouse dishevelled-3."
    Tsang M., Lijam N., Yang Y., Beier D.R., Wynshaw-Boris A., Sussman D.J.
    Dev. Dyn. 207:253-262(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: BALB/c.
    Tissue: Brain.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  3. Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
    Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "Regulation of the Wnt signaling pathway by disabled-2 (Dab2)."
    Howe P.H.
    EMBO J. 22:3084-3094(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH DAB2.
  5. "Independent mutations in mouse Vangl2 that cause neural tube defects in looptail mice impair interaction with members of the Dishevelled family."
    Torban E., Wang H.-J., Groulx N., Gros P.
    J. Biol. Chem. 279:52703-52713(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH VANGL1 AND VANGL2.

Entry informationi

Entry nameiDVL3_MOUSE
AccessioniPrimary (citable) accession number: Q61062
Secondary accession number(s): G5E820
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: October 3, 2012
Last modified: November 26, 2014
This is version 120 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3