Q61062 (DVL3_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Segment polarity protein dishevelled homolog DVL-3
Short name=Dishevelled-3

Alternative name(s):
DSH homolog 3

Gene names

Name:

Dvl3

Organism

Mus musculus (Mouse) [Reference proteome]

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length	716 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	May play a role in the signal transduction pathway mediated by multiple Wnt genes.
Subunit structure	Interacts (via the PDZ domain) with the C-terminal regions of VANGL1 and VANGL2. Interacts (via the region containing both the PDZ and DEP domains) with LRRFIP2; the DIX domain may inhibit this interaction. Interacts with CYLD. Interacts with CEP164 and DAB2. Ref.4 Ref.5
Subcellular location	Cytoplasm By similarity.
Tissue specificity	Ubiquitous.
Post-translational modification	Ubiquitinated. Deubiquitinated by CYLD, which acts on 'Lys-63'-linked ubiquitin chains By similarity. Phosphorylated by CSNK1D By similarity.
Sequence similarities	Belongs to the DSH family. Contains 1 DEP domain. Contains 1 DIX domain. Contains 1 PDZ (DHR) domain.

Ontologies

Keywords
Biological process	Wnt signaling pathway
Cellular component	Cytoplasm
Molecular function	Developmental protein
PTM	Methylation Phosphoprotein Ubl conjugation
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	canonical Wnt receptor signaling pathway Traceable author statement PubMed 11274398. Source: BHF-UCL cochlea morphogenesis Inferred from genetic interaction PubMed 19008950. Source: MGI convergent extension Inferred from Biological aspect of Ancestor. Source: RefGenome intracellular signal transduction Inferred from electronic annotation. Source: InterPro non-canonical Wnt receptor signaling pathway via JNK cascade Inferred from direct assay PubMed 11274398. Source: BHF-UCL outflow tract septum morphogenesis Inferred from mutant phenotype PubMed 19008950. Source: MGI planar cell polarity pathway involved in neural tube closure Inferred from genetic interaction PubMed 19008950. Source: MGI positive regulation of JUN kinase activity Inferred from electronic annotation. Source: Compara positive regulation of transcription, DNA-dependent Inferred from Biological aspect of Ancestor. Source: RefGenome regulation of signaling Inferred from Biological aspect of Ancestor. Source: RefGenome response to drug Inferred from electronic annotation. Source: Compara
Cellular_component	cell cortex Inferred from Biological aspect of Ancestor. Source: RefGenome
Molecular_function	beta-catenin binding Inferred from Biological aspect of Ancestor. Source: RefGenome frizzled binding Inferred from Biological aspect of Ancestor. Source: RefGenome signal transducer activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Binary interactions

With	Entry	#Exp.	IntAct	Notes
Axin1	O35625	2	EBI-1538450,EBI-2365912
Dvl2	Q60838	3	EBI-1538450,EBI-641940
Vangl1	Q80Z96	2	EBI-1538450,EBI-1750708
Vangl2	Q91ZD4	2	EBI-1538450,EBI-1750744

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 716	716	Segment polarity protein dishevelled homolog DVL-3		PRO_0000145750
Regions
	Domain	1 – 82	82	DIX
	Domain	249 – 321	73	PDZ
	Domain	422 – 496	75	DEP
Amino acid modifications
	Modified residue	27	1	Omega-N-methylarginine By similarity
	Modified residue	48	1	Phosphoserine By similarity
	Modified residue	192	1	Phosphoserine By similarity
	Modified residue	212	1	Omega-N-methylarginine By similarity
	Modified residue	342	1	Omega-N-methylarginine By similarity
	Modified residue	346	1	Phosphothreonine By similarity
	Modified residue	698	1	Dimethylated arginine; alternate By similarity
	Modified residue	698	1	Omega-N-methylarginine; alternate By similarity
	Modified residue	700	1	Phosphoserine By similarity
Experimental info
	Sequence conflict	460	1	D → E in AAB01761. Ref.1
	Sequence conflict	674	1	A → G in AAB01761. Ref.1

Sequences

	Sequence		Length	Mass (Da)
	Q61062 [UniParc]. Last modified October 3, 2012. Version 2. Checksum: 552A5BE4BEA801F0	FASTA	716	78,123
	10 20 30 40 50 60 MGETKIIYHL DGQETPYLVK LPLPAERVTL ADFKGVLQRP SYKFFFKSMD DDFGVVKEEI 70 80 90 100 110 120 SDDNAKLPCF NGRVVSWLVS AEGSHPEPAP FCADNPSELP PSMERTGGIG DSRPPSFHPH 130 140 150 160 170 180 ASGGSQENLD NDTETDSLVS AQRERPRRRD GPEHAARLNG TTKGERRREP GGYDSSSTLM 190 200 210 220 230 240 SSELETTSFF DSDEDDSTSR FSSSTEQSSA SRLMRRHKRR RRKQKVSRIE RSSSFSSITD 250 260 270 280 290 300 STMSLNIITV TLNMEKYNFL GISIVGQSNE RGDGGIYIGS IMKGGAVAAD GRIEPGDMLL 310 320 330 340 350 360 QVNEINFENM SNDDAVRVLR EIVHKPGPIT LTVAKCWDPS PRGCFTLPRS EPIRPIDPAA 370 380 390 400 410 420 WVSHTAAMTG TFPAYGMSPS LSTITSTSSS ITSSIPDTER LDDFHLSIHS DMAAIVKAMA 430 440 450 460 470 480 SPESGLEVRD RMWLKITIPN AFIGSDVVDW LYHNVEGFTD RREARKYASN LLKAGFIRHT 490 500 510 520 530 540 VNKITFSEQC YYIFGDLCGN MANLSLHDHD GSSGASDQDT LAPLPHPGAA PWPMAFPYQY 550 560 570 580 590 600 PPPPHPYNPH PGFPELGYSY GGGSASSQHS EGSRSSGSNR SGSDRRKEKD PKAGDSKSGG 610 620 630 640 650 660 SGSESDHTTR SSLRGPRERA PSERSGPAAS EHSHRSHHSL TSSLRSHHTH PSYGPPGVPP 670 680 690 700 710 LYGPPMLMMT PPPAAMGPPG APPGRDLASV PPELTASRQS FRMAMGNPSE FFVDVM

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Isolation and characterization of mouse dishevelled-3." Tsang M., Lijam N., Yang Y., Beier D.R., Wynshaw-Boris A., Sussman D.J. Dev. Dyn. 207:253-262(1996) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Strain: BALB/c. Tissue: Brain.
[2]	"Lineage-specific biology revealed by a finished genome assembly of the mouse." Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X., Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y., Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S. , Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R., Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K., Eichler E.E., Ponting C.P. PLoS Biol. 7:E1000112-E1000112(2009) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: C57BL/6J.
[3]	Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C. Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]	"Regulation of the Wnt signaling pathway by disabled-2 (Dab2)." Howe P.H. EMBO J. 22:3084-3094(2003) [PubMed] [Europe PMC] [Abstract] Cited for: INTERACTION WITH DAB2.
[5]	"Independent mutations in mouse Vangl2 that cause neural tube defects in looptail mice impair interaction with members of the Dishevelled family." Torban E., Wang H.-J., Groulx N., Gros P. J. Biol. Chem. 279:52703-52713(2004) [PubMed] [Europe PMC] [Abstract] Cited for: INTERACTION WITH VANGL1 AND VANGL2.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	U41285 mRNA. Translation: AAB01761.1. AC087898 Genomic DNA. No translation available. CH466521 Genomic DNA. Translation: EDK97570.1.
IPI	IPI00117059.
RefSeq	NP_031915.2. NM_007889.2.
UniGene	Mm.247259. Mm.272443.
3D structure databases
ProteinModelPortal	Q61062.
SMR	Q61062. Positions 3-79, 247-335, 411-499.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q61062. 13 interactions.
STRING	10090.ENSMUSP00000003318.
PTM databases
PhosphoSite	Q61062.
Proteomic databases
PaxDb	Q61062.
PRIDE	Q61062.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSMUST00000003318; ENSMUSP00000003318; ENSMUSG00000003233.
GeneID	13544.
KEGG	mmu:13544.
UCSC	uc007ypw.1. mouse.
Organism-specific databases
CTD	1857.
MGI	MGI:108100. Dvl3.
Phylogenomic databases
eggNOG	NOG322275.
GeneTree	ENSGT00390000013552.
HOGENOM	HOG000017084.
HOVERGEN	HBG005542.
InParanoid	Q61062.
KO	K02353.
OrthoDB	EOG4TQM8S.
Gene expression databases
CleanEx	MM_DVL3.
Genevestigator	Q61062.
GermOnline	ENSMUSG00000003233. Mus musculus.
Family and domain databases
Gene3D	1.10.10.10. 1 hit.
InterPro	IPR000591. DEP_dom. IPR008342. Dishevelled_3. IPR024580. Dishevelled_C-dom. IPR008339. Dishevelled_fam. IPR003351. Dishevelled_protein_dom. IPR001158. DIX. IPR015506. Dsh/Dvl-rel. IPR001478. PDZ. IPR011991. WHTH_DNA-bd_dom. [Graphical view]
PANTHER	PTHR10878. PTHR10878. 1 hit. PTHR10878:SF6. PTHR10878:SF6. 1 hit.
Pfam	PF00610. DEP. 1 hit. PF02377. Dishevelled. 1 hit. PF00778. DIX. 1 hit. PF12316. Dsh_C. 1 hit. PF00595. PDZ. 1 hit. [Graphical view]
PRINTS	PR01760. DISHEVELLED. PR01763. DISHEVELLED3.
SMART	SM00021. DAX. 1 hit. SM00049. DEP. 1 hit. SM00228. PDZ. 1 hit. [Graphical view]
SUPFAM	SSF50156. PDZ. 1 hit.
PROSITE	PS50186. DEP. 1 hit. PS50841. DIX. 1 hit. PS50106. PDZ. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	284150.
SOURCE	Search...

Entry information

Entry name

DVL3_MOUSE

Accession

Primary (citable) accession number: Q61062
Secondary accession number(s): G5E820

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 30, 2000
Last sequence update:	October 3, 2012
Last modified:	May 1, 2013
This is version 106 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program