Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Q61060

- FOXD3_MOUSE

UniProt

Q61060 - FOXD3_MOUSE

Protein

Forkhead box protein D3

Gene

Foxd3

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 111 (01 Oct 2014)
      Sequence version 3 (10 May 2005)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Binds to the consensus sequence 5'-A[AT]T[AG]TTTGTTT-3' and acts as a transcriptional repressor. Also acts as a transcriptional activator. Promotes development of neural crest cells from neural tube progenitors. Restricts neural progenitor cells to the neural crest lineage while suppressing interneuron differentiation. Required for maintenance of pluripotent cells in the pre-implantation and peri-implantation stages of embryogenesis.2 Publications

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    DNA bindingi130 – 22192Fork-headPROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. double-stranded DNA binding Source: Ensembl
    2. RNA polymerase II regulatory region sequence-specific DNA binding Source: Ensembl
    3. RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription Source: Ensembl
    4. sequence-specific DNA binding transcription factor activity Source: UniProtKB
    5. transcription regulatory region DNA binding Source: MGI

    GO - Biological processi

    1. embryonic placenta development Source: MGI
    2. in utero embryonic development Source: UniProtKB
    3. negative regulation of transcription from RNA polymerase II promoter Source: UniProtKB
    4. positive regulation of transcription from RNA polymerase II promoter Source: UniProtKB
    5. transcription, DNA-templated Source: MGI
    6. trophectodermal cell differentiation Source: MGI

    Keywords - Molecular functioni

    Activator, Developmental protein, Repressor

    Keywords - Biological processi

    Transcription, Transcription regulation

    Keywords - Ligandi

    DNA-binding

    Enzyme and pathway databases

    ReactomeiREACT_220962. POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Forkhead box protein D3
    Alternative name(s):
    HNF3/FH transcription factor genesis
    Hepatocyte nuclear factor 3 forkhead homolog 2
    Short name:
    HFH-2
    Gene namesi
    Name:Foxd3
    Synonyms:Hfh2
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Unplaced

    Organism-specific databases

    MGIiMGI:1347473. Foxd3.

    Subcellular locationi

    Nucleus Curated

    GO - Cellular componenti

    1. nuclear chromatin Source: Ensembl
    2. nucleus Source: UniProtKB
    3. transcription factor complex Source: MGI

    Keywords - Cellular componenti

    Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 465465Forkhead box protein D3PRO_0000091818Add
    BLAST

    Proteomic databases

    PRIDEiQ61060.

    PTM databases

    PhosphoSiteiQ61060.

    Expressioni

    Tissue specificityi

    Expressed in premigratory and migrating neural crest cells in the early embryo and in motorneuron and interneuron progenitors in the developing spinal cord.2 Publications

    Developmental stagei

    During early embryogenesis, not expressed in unfertilized oocytes or fertilized one-cell embryos but detected in blastocysts.1 Publication

    Gene expression databases

    BgeeiQ61060.
    CleanExiMM_FOXD3.
    GenevestigatoriQ61060.

    Structurei

    3D structure databases

    ProteinModelPortaliQ61060.
    SMRiQ61060. Positions 130-226.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi248 – 464217Ala-richAdd
    BLAST
    Compositional biasi369 – 39931Gly-richAdd
    BLAST

    Sequence similaritiesi

    Contains 1 fork-head DNA-binding domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiCOG5025.
    HOVERGENiHBG051641.
    InParanoidiQ61060.
    KOiK09397.

    Family and domain databases

    Gene3Di1.10.10.10. 1 hit.
    InterProiIPR001766. TF_fork_head.
    IPR018122. TF_fork_head_CS.
    IPR011991. WHTH_DNA-bd_dom.
    [Graphical view]
    PfamiPF00250. Fork_head. 1 hit.
    [Graphical view]
    PRINTSiPR00053. FORKHEAD.
    SMARTiSM00339. FH. 1 hit.
    [Graphical view]
    PROSITEiPS00657. FORK_HEAD_1. 1 hit.
    PS00658. FORK_HEAD_2. 1 hit.
    PS50039. FORK_HEAD_3. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q61060-1 [UniParc]FASTAAdd to Basket

    « Hide

    MTLSGSGSAS DMSGQTVLTA EDVDIDVVGE GDDGLEEKDS DAGCDSPAGP    50
    PDLRLDEADE GPPVSAHHGQ SQPQALALPT EATGPGNDTG APEADGCKGG 100
    EDAVTGGGGP GAGSGATGGL TPNKPKNSLV KPPYSYIALI TMAILQSPQK 150
    KLTLSGICEF ISNRFPYYRE KFPAWQNSIR HNLSLNDCFV KIPREPGNPG 200
    KGNYWTLDPQ SEDMFDNGSF LRRRKRFKRH QQEHLREQTA LMMQSFGAYS 250
    LAAAAGAGPY GLHPAAAAGA YSHPAAAAAA AAAAALQYPY ALPPVAPVLP 300
    PAVPLLPSGE LGRKAAAFGS QLGPSLQLQL NTLGAAAAAA GTAGAAGTTS 350
    LIKSEPSARP SFSIENIIGA GSAAPGGSAG GGGSGGGAGG GGGSGGGGGA 400
    QSFLRPPGTV QSAALMATHQ PLSLSRTTAT IAPILSVPLS GQFLQPAASA 450
    AAAAAAAVQA KWPAQ 465
    Length:465
    Mass (Da):46,345
    Last modified:May 10, 2005 - v3
    Checksum:i7277EB2EE2C8E0C2
    GO

    Sequence cautioni

    The sequence AAA87569.1 differs from that shown. Reason: Frameshift at positions 282 and 374.

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U41047 mRNA. Translation: AAA87569.1. Frameshift.
    AF067421 mRNA. Translation: AAC28352.2.
    BX005053 Genomic DNA. No translation available.
    RefSeqiNP_034555.3. NM_010425.3.
    UniGeneiMm.4758.

    Genome annotation databases

    GeneIDi15221.
    KEGGimmu:15221.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U41047 mRNA. Translation: AAA87569.1 . Frameshift.
    AF067421 mRNA. Translation: AAC28352.2 .
    BX005053 Genomic DNA. No translation available.
    RefSeqi NP_034555.3. NM_010425.3.
    UniGenei Mm.4758.

    3D structure databases

    ProteinModelPortali Q61060.
    SMRi Q61060. Positions 130-226.
    ModBasei Search...
    MobiDBi Search...

    PTM databases

    PhosphoSitei Q61060.

    Proteomic databases

    PRIDEi Q61060.

    Protocols and materials databases

    DNASUi 15221.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 15221.
    KEGGi mmu:15221.

    Organism-specific databases

    CTDi 27022.
    MGIi MGI:1347473. Foxd3.

    Phylogenomic databases

    eggNOGi COG5025.
    HOVERGENi HBG051641.
    InParanoidi Q61060.
    KOi K09397.

    Enzyme and pathway databases

    Reactomei REACT_220962. POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation.

    Miscellaneous databases

    NextBioi 287807.
    PROi Q61060.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q61060.
    CleanExi MM_FOXD3.
    Genevestigatori Q61060.

    Family and domain databases

    Gene3Di 1.10.10.10. 1 hit.
    InterProi IPR001766. TF_fork_head.
    IPR018122. TF_fork_head_CS.
    IPR011991. WHTH_DNA-bd_dom.
    [Graphical view ]
    Pfami PF00250. Fork_head. 1 hit.
    [Graphical view ]
    PRINTSi PR00053. FORKHEAD.
    SMARTi SM00339. FH. 1 hit.
    [Graphical view ]
    PROSITEi PS00657. FORK_HEAD_1. 1 hit.
    PS00658. FORK_HEAD_2. 1 hit.
    PS50039. FORK_HEAD_3. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Genesis, a winged helix transcriptional repressor with expression restricted to embryonic stem cells."
      Sutton J., Costa R., Klug M., Field L., Xu D., Largaespada D.A., Fletcher C.F., Jenkins N.A., Copeland N.G., Klemsz M., Hromas R.
      J. Biol. Chem. 271:23126-23133(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION.
      Tissue: Embryonic carcinoma.
    2. "The winged helix transcription factor Hfh2 is expressed in neural crest and spinal cord during mouse development."
      Labosky P.A., Kaestner K.H.
      Mech. Dev. 76:185-190(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
      Tissue: Embryo.
    3. Kessler D.S., Labosky P.A., Kaestner K.H.
      Submitted (JAN-2005) to the EMBL/GenBank/DDBJ databases
      Cited for: SEQUENCE REVISION.
    4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: C57BL/6J.
    5. "Requirement for Foxd3 in maintaining pluripotent cells of the early mouse embryo."
      Hanna L.A., Foreman R.K., Tarasenko I.A., Kessler D.S., Labosky P.A.
      Genes Dev. 16:2650-2661(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, DEVELOPMENTAL STAGE.
    6. "The winged-helix transcription factor Foxd3 suppresses interneuron differentiation and promotes neural crest cell fate."
      Dottori M., Gross M.K., Labosky P., Goulding M.
      Development 128:4127-4138(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: TISSUE SPECIFICITY.

    Entry informationi

    Entry nameiFOXD3_MOUSE
    AccessioniPrimary (citable) accession number: Q61060
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 15, 1998
    Last sequence update: May 10, 2005
    Last modified: October 1, 2014
    This is version 111 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3