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Q61060

- FOXD3_MOUSE

UniProt

Q61060 - FOXD3_MOUSE

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Protein
Forkhead box protein D3
Gene
Foxd3, Hfh2
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at transcript leveli

Functioni

Binds to the consensus sequence 5'-A[AT]T[AG]TTTGTTT-3' and acts as a transcriptional repressor. Also acts as a transcriptional activator. Promotes development of neural crest cells from neural tube progenitors. Restricts neural progenitor cells to the neural crest lineage while suppressing interneuron differentiation. Required for maintenance of pluripotent cells in the pre-implantation and peri-implantation stages of embryogenesis.2 Publications

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi130 – 22192Fork-head
Add
BLAST

GO - Molecular functioni

  1. DNA binding, bending Source: RefGenome
  2. RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity Source: RefGenome
  3. RNA polymerase II regulatory region sequence-specific DNA binding Source: Ensembl
  4. RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription Source: Ensembl
  5. double-stranded DNA binding Source: RefGenome
  6. sequence-specific DNA binding transcription factor activity Source: UniProtKB
  7. transcription factor binding Source: RefGenome
  8. transcription regulatory region DNA binding Source: MGI

GO - Biological processi

  1. axon extension involved in axon guidance Source: RefGenome
  2. branching involved in ureteric bud morphogenesis Source: RefGenome
  3. cartilage development Source: RefGenome
  4. embryonic placenta development Source: MGI
  5. enteric nervous system development Source: RefGenome
  6. in utero embryonic development Source: UniProtKB
  7. iridophore differentiation Source: RefGenome
  8. kidney development Source: RefGenome
  9. lateral line nerve glial cell development Source: RefGenome
  10. melanocyte differentiation Source: RefGenome
  11. negative regulation of transcription from RNA polymerase II promoter Source: UniProtKB
  12. neural crest cell migration Source: RefGenome
  13. pattern specification process Source: RefGenome
  14. peripheral nervous system development Source: RefGenome
  15. positive regulation of transcription from RNA polymerase II promoter Source: UniProtKB
  16. regulation of sequence-specific DNA binding transcription factor activity Source: RefGenome
  17. sympathetic nervous system development Source: RefGenome
  18. transcription from RNA polymerase II promoter Source: GOC
  19. transcription, DNA-templated Source: MGI
  20. trophectodermal cell differentiation Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

Activator, Developmental protein, Repressor

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Enzyme and pathway databases

ReactomeiREACT_220962. POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation.

Names & Taxonomyi

Protein namesi
Recommended name:
Forkhead box protein D3
Alternative name(s):
HNF3/FH transcription factor genesis
Hepatocyte nuclear factor 3 forkhead homolog 2
Short name:
HFH-2
Gene namesi
Name:Foxd3
Synonyms:Hfh2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Unplaced

Organism-specific databases

MGIiMGI:1347473. Foxd3.

Subcellular locationi

Nucleus Inferred

GO - Cellular componenti

  1. nuclear chromatin Source: Ensembl
  2. nucleus Source: UniProtKB
  3. transcription factor complex Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 465465Forkhead box protein D3
PRO_0000091818Add
BLAST

Proteomic databases

PRIDEiQ61060.

PTM databases

PhosphoSiteiQ61060.

Expressioni

Tissue specificityi

Expressed in premigratory and migrating neural crest cells in the early embryo and in motorneuron and interneuron progenitors in the developing spinal cord.2 Publications

Developmental stagei

During early embryogenesis, not expressed in unfertilized oocytes or fertilized one-cell embryos but detected in blastocysts.1 Publication

Gene expression databases

BgeeiQ61060.
CleanExiMM_FOXD3.
GenevestigatoriQ61060.

Structurei

3D structure databases

ProteinModelPortaliQ61060.
SMRiQ61060. Positions 130-226.

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi248 – 464217Ala-rich
Add
BLAST
Compositional biasi369 – 39931Gly-rich
Add
BLAST

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG5025.
HOVERGENiHBG051641.
InParanoidiQ61060.
KOiK09397.

Family and domain databases

Gene3Di1.10.10.10. 1 hit.
InterProiIPR001766. TF_fork_head.
IPR018122. TF_fork_head_CS.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PfamiPF00250. Fork_head. 1 hit.
[Graphical view]
PRINTSiPR00053. FORKHEAD.
SMARTiSM00339. FH. 1 hit.
[Graphical view]
PROSITEiPS00657. FORK_HEAD_1. 1 hit.
PS00658. FORK_HEAD_2. 1 hit.
PS50039. FORK_HEAD_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q61060-1 [UniParc]FASTAAdd to Basket

« Hide

MTLSGSGSAS DMSGQTVLTA EDVDIDVVGE GDDGLEEKDS DAGCDSPAGP    50
PDLRLDEADE GPPVSAHHGQ SQPQALALPT EATGPGNDTG APEADGCKGG 100
EDAVTGGGGP GAGSGATGGL TPNKPKNSLV KPPYSYIALI TMAILQSPQK 150
KLTLSGICEF ISNRFPYYRE KFPAWQNSIR HNLSLNDCFV KIPREPGNPG 200
KGNYWTLDPQ SEDMFDNGSF LRRRKRFKRH QQEHLREQTA LMMQSFGAYS 250
LAAAAGAGPY GLHPAAAAGA YSHPAAAAAA AAAAALQYPY ALPPVAPVLP 300
PAVPLLPSGE LGRKAAAFGS QLGPSLQLQL NTLGAAAAAA GTAGAAGTTS 350
LIKSEPSARP SFSIENIIGA GSAAPGGSAG GGGSGGGAGG GGGSGGGGGA 400
QSFLRPPGTV QSAALMATHQ PLSLSRTTAT IAPILSVPLS GQFLQPAASA 450
AAAAAAAVQA KWPAQ 465
Length:465
Mass (Da):46,345
Last modified:May 10, 2005 - v3
Checksum:i7277EB2EE2C8E0C2
GO

Sequence cautioni

The sequence AAA87569.1 differs from that shown. Reason: Frameshift at positions 282 and 374.

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U41047 mRNA. Translation: AAA87569.1. Frameshift.
AF067421 mRNA. Translation: AAC28352.2.
BX005053 Genomic DNA. No translation available.
RefSeqiNP_034555.3. NM_010425.3.
UniGeneiMm.4758.

Genome annotation databases

GeneIDi15221.
KEGGimmu:15221.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U41047 mRNA. Translation: AAA87569.1 . Frameshift.
AF067421 mRNA. Translation: AAC28352.2 .
BX005053 Genomic DNA. No translation available.
RefSeqi NP_034555.3. NM_010425.3.
UniGenei Mm.4758.

3D structure databases

ProteinModelPortali Q61060.
SMRi Q61060. Positions 130-226.
ModBasei Search...
MobiDBi Search...

PTM databases

PhosphoSitei Q61060.

Proteomic databases

PRIDEi Q61060.

Protocols and materials databases

DNASUi 15221.
Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 15221.
KEGGi mmu:15221.

Organism-specific databases

CTDi 27022.
MGIi MGI:1347473. Foxd3.

Phylogenomic databases

eggNOGi COG5025.
HOVERGENi HBG051641.
InParanoidi Q61060.
KOi K09397.

Enzyme and pathway databases

Reactomei REACT_220962. POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation.

Miscellaneous databases

NextBioi 287807.
PROi Q61060.
SOURCEi Search...

Gene expression databases

Bgeei Q61060.
CleanExi MM_FOXD3.
Genevestigatori Q61060.

Family and domain databases

Gene3Di 1.10.10.10. 1 hit.
InterProi IPR001766. TF_fork_head.
IPR018122. TF_fork_head_CS.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view ]
Pfami PF00250. Fork_head. 1 hit.
[Graphical view ]
PRINTSi PR00053. FORKHEAD.
SMARTi SM00339. FH. 1 hit.
[Graphical view ]
PROSITEi PS00657. FORK_HEAD_1. 1 hit.
PS00658. FORK_HEAD_2. 1 hit.
PS50039. FORK_HEAD_3. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Genesis, a winged helix transcriptional repressor with expression restricted to embryonic stem cells."
    Sutton J., Costa R., Klug M., Field L., Xu D., Largaespada D.A., Fletcher C.F., Jenkins N.A., Copeland N.G., Klemsz M., Hromas R.
    J. Biol. Chem. 271:23126-23133(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION.
    Tissue: Embryonic carcinoma.
  2. "The winged helix transcription factor Hfh2 is expressed in neural crest and spinal cord during mouse development."
    Labosky P.A., Kaestner K.H.
    Mech. Dev. 76:185-190(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
    Tissue: Embryo.
  3. Kessler D.S., Labosky P.A., Kaestner K.H.
    Submitted (JAN-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: SEQUENCE REVISION.
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  5. "Requirement for Foxd3 in maintaining pluripotent cells of the early mouse embryo."
    Hanna L.A., Foreman R.K., Tarasenko I.A., Kessler D.S., Labosky P.A.
    Genes Dev. 16:2650-2661(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, DEVELOPMENTAL STAGE.
  6. "The winged-helix transcription factor Foxd3 suppresses interneuron differentiation and promotes neural crest cell fate."
    Dottori M., Gross M.K., Labosky P., Goulding M.
    Development 128:4127-4138(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: TISSUE SPECIFICITY.

Entry informationi

Entry nameiFOXD3_MOUSE
AccessioniPrimary (citable) accession number: Q61060
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 15, 1998
Last sequence update: May 10, 2005
Last modified: September 3, 2014
This is version 110 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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