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Q61060

- FOXD3_MOUSE

UniProt

Q61060 - FOXD3_MOUSE

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Protein

Forkhead box protein D3

Gene

Foxd3

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli

Functioni

Binds to the consensus sequence 5'-A[AT]T[AG]TTTGTTT-3' and acts as a transcriptional repressor. Also acts as a transcriptional activator. Promotes development of neural crest cells from neural tube progenitors. Restricts neural progenitor cells to the neural crest lineage while suppressing interneuron differentiation. Required for maintenance of pluripotent cells in the pre-implantation and peri-implantation stages of embryogenesis.2 Publications

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi130 – 22192Fork-headPROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

  1. double-stranded DNA binding Source: Ensembl
  2. RNA polymerase II regulatory region sequence-specific DNA binding Source: Ensembl
  3. RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription Source: Ensembl
  4. sequence-specific DNA binding transcription factor activity Source: UniProtKB
  5. transcription regulatory region DNA binding Source: MGI

GO - Biological processi

  1. embryonic placenta development Source: MGI
  2. in utero embryonic development Source: UniProtKB
  3. negative regulation of transcription from RNA polymerase II promoter Source: UniProtKB
  4. positive regulation of transcription from RNA polymerase II promoter Source: UniProtKB
  5. transcription, DNA-templated Source: MGI
  6. trophectodermal cell differentiation Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

Activator, Developmental protein, Repressor

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Enzyme and pathway databases

ReactomeiREACT_220962. POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation.

Names & Taxonomyi

Protein namesi
Recommended name:
Forkhead box protein D3
Alternative name(s):
HNF3/FH transcription factor genesis
Hepatocyte nuclear factor 3 forkhead homolog 2
Short name:
HFH-2
Gene namesi
Name:Foxd3
Synonyms:Hfh2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Unplaced

Organism-specific databases

MGIiMGI:1347473. Foxd3.

Subcellular locationi

Nucleus Curated

GO - Cellular componenti

  1. nuclear chromatin Source: Ensembl
  2. nucleus Source: UniProtKB
  3. transcription factor complex Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 465465Forkhead box protein D3PRO_0000091818Add
BLAST

Proteomic databases

PRIDEiQ61060.

PTM databases

PhosphoSiteiQ61060.

Expressioni

Tissue specificityi

Expressed in premigratory and migrating neural crest cells in the early embryo and in motorneuron and interneuron progenitors in the developing spinal cord.2 Publications

Developmental stagei

During early embryogenesis, not expressed in unfertilized oocytes or fertilized one-cell embryos but detected in blastocysts.1 Publication

Gene expression databases

BgeeiQ61060.
CleanExiMM_FOXD3.
ExpressionAtlasiQ61060. baseline.
GenevestigatoriQ61060.

Structurei

3D structure databases

ProteinModelPortaliQ61060.
SMRiQ61060. Positions 130-226.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi248 – 464217Ala-richAdd
BLAST
Compositional biasi369 – 39931Gly-richAdd
BLAST

Sequence similaritiesi

Contains 1 fork-head DNA-binding domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiCOG5025.
HOVERGENiHBG051641.
InParanoidiQ61060.
KOiK09397.

Family and domain databases

Gene3Di1.10.10.10. 1 hit.
InterProiIPR001766. TF_fork_head.
IPR018122. TF_fork_head_CS.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PfamiPF00250. Fork_head. 1 hit.
[Graphical view]
PRINTSiPR00053. FORKHEAD.
SMARTiSM00339. FH. 1 hit.
[Graphical view]
PROSITEiPS00657. FORK_HEAD_1. 1 hit.
PS00658. FORK_HEAD_2. 1 hit.
PS50039. FORK_HEAD_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q61060 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MTLSGSGSAS DMSGQTVLTA EDVDIDVVGE GDDGLEEKDS DAGCDSPAGP
60 70 80 90 100
PDLRLDEADE GPPVSAHHGQ SQPQALALPT EATGPGNDTG APEADGCKGG
110 120 130 140 150
EDAVTGGGGP GAGSGATGGL TPNKPKNSLV KPPYSYIALI TMAILQSPQK
160 170 180 190 200
KLTLSGICEF ISNRFPYYRE KFPAWQNSIR HNLSLNDCFV KIPREPGNPG
210 220 230 240 250
KGNYWTLDPQ SEDMFDNGSF LRRRKRFKRH QQEHLREQTA LMMQSFGAYS
260 270 280 290 300
LAAAAGAGPY GLHPAAAAGA YSHPAAAAAA AAAAALQYPY ALPPVAPVLP
310 320 330 340 350
PAVPLLPSGE LGRKAAAFGS QLGPSLQLQL NTLGAAAAAA GTAGAAGTTS
360 370 380 390 400
LIKSEPSARP SFSIENIIGA GSAAPGGSAG GGGSGGGAGG GGGSGGGGGA
410 420 430 440 450
QSFLRPPGTV QSAALMATHQ PLSLSRTTAT IAPILSVPLS GQFLQPAASA
460
AAAAAAAVQA KWPAQ
Length:465
Mass (Da):46,345
Last modified:May 10, 2005 - v3
Checksum:i7277EB2EE2C8E0C2
GO

Sequence cautioni

The sequence AAA87569.1 differs from that shown. Reason: Frameshift at positions 282 and 374.

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U41047 mRNA. Translation: AAA87569.1. Frameshift.
AF067421 mRNA. Translation: AAC28352.2.
BX005053 Genomic DNA. No translation available.
RefSeqiNP_034555.3. NM_010425.3.
UniGeneiMm.4758.

Genome annotation databases

GeneIDi15221.
KEGGimmu:15221.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U41047 mRNA. Translation: AAA87569.1 . Frameshift.
AF067421 mRNA. Translation: AAC28352.2 .
BX005053 Genomic DNA. No translation available.
RefSeqi NP_034555.3. NM_010425.3.
UniGenei Mm.4758.

3D structure databases

ProteinModelPortali Q61060.
SMRi Q61060. Positions 130-226.
ModBasei Search...
MobiDBi Search...

PTM databases

PhosphoSitei Q61060.

Proteomic databases

PRIDEi Q61060.

Protocols and materials databases

DNASUi 15221.
Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 15221.
KEGGi mmu:15221.

Organism-specific databases

CTDi 27022.
MGIi MGI:1347473. Foxd3.

Phylogenomic databases

eggNOGi COG5025.
HOVERGENi HBG051641.
InParanoidi Q61060.
KOi K09397.

Enzyme and pathway databases

Reactomei REACT_220962. POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation.

Miscellaneous databases

NextBioi 287807.
PROi Q61060.
SOURCEi Search...

Gene expression databases

Bgeei Q61060.
CleanExi MM_FOXD3.
ExpressionAtlasi Q61060. baseline.
Genevestigatori Q61060.

Family and domain databases

Gene3Di 1.10.10.10. 1 hit.
InterProi IPR001766. TF_fork_head.
IPR018122. TF_fork_head_CS.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view ]
Pfami PF00250. Fork_head. 1 hit.
[Graphical view ]
PRINTSi PR00053. FORKHEAD.
SMARTi SM00339. FH. 1 hit.
[Graphical view ]
PROSITEi PS00657. FORK_HEAD_1. 1 hit.
PS00658. FORK_HEAD_2. 1 hit.
PS50039. FORK_HEAD_3. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Genesis, a winged helix transcriptional repressor with expression restricted to embryonic stem cells."
    Sutton J., Costa R., Klug M., Field L., Xu D., Largaespada D.A., Fletcher C.F., Jenkins N.A., Copeland N.G., Klemsz M., Hromas R.
    J. Biol. Chem. 271:23126-23133(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION.
    Tissue: Embryonic carcinoma.
  2. "The winged helix transcription factor Hfh2 is expressed in neural crest and spinal cord during mouse development."
    Labosky P.A., Kaestner K.H.
    Mech. Dev. 76:185-190(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
    Tissue: Embryo.
  3. Kessler D.S., Labosky P.A., Kaestner K.H.
    Submitted (JAN-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: SEQUENCE REVISION.
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  5. "Requirement for Foxd3 in maintaining pluripotent cells of the early mouse embryo."
    Hanna L.A., Foreman R.K., Tarasenko I.A., Kessler D.S., Labosky P.A.
    Genes Dev. 16:2650-2661(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, DEVELOPMENTAL STAGE.
  6. "The winged-helix transcription factor Foxd3 suppresses interneuron differentiation and promotes neural crest cell fate."
    Dottori M., Gross M.K., Labosky P., Goulding M.
    Development 128:4127-4138(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: TISSUE SPECIFICITY.

Entry informationi

Entry nameiFOXD3_MOUSE
AccessioniPrimary (citable) accession number: Q61060
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 15, 1998
Last sequence update: May 10, 2005
Last modified: October 29, 2014
This is version 112 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3