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Protein
Submitted name:

Trp-related protein 2

Gene

Trpc2

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

  • calmodulin binding Source: MGI
  • diacylglycerol binding Source: MGI
  • store-operated calcium channel activity Source: MGI

GO - Biological processi

  • acrosome reaction Source: MGI
  • calcium ion transport Source: MGI
  • female courtship behavior Source: MGI
  • inter-male aggressive behavior Source: MGI
  • manganese ion transport Source: GO_Central
  • mating behavior, sex discrimination Source: MGI
  • negative regulation of male mating behavior Source: MGI
  • positive regulation of cytosolic calcium ion concentration Source: MGI
  • regulation of gene expression Source: MGI
  • response to pheromone Source: MGI
  • territorial aggressive behavior Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

Ion channelUniRule annotation

Keywords - Biological processi

Ion transport, Transport

Names & Taxonomyi

Protein namesi
Submitted name:
Trp-related protein 2Imported
Gene namesi
Name:Trpc2Imported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Organism-specific databases

MGIiMGI:109527. Trpc2.

Subcellular locationi

GO - Cellular componenti

  • cytosol Source: GOC
  • dendrite membrane Source: MGI
  • endomembrane system Source: MGI
  • endoplasmic reticulum membrane Source: MGI
  • Golgi membrane Source: MGI
  • integral component of plasma membrane Source: GO_Central
  • nuclear envelope Source: MGI
  • plasma membrane Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Expressioni

Gene expression databases

BgeeiQ61057.
ExpressionAtlasiQ61057. baseline.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000081903.

Family & Domainsi

Keywords - Domaini

TransmembraneUniRule annotation

Family and domain databases

InterProiIPR005821. Ion_trans_dom.
IPR005458. TRPC2_channel.
IPR002153. TRPC_channel.
[Graphical view]
PANTHERiPTHR10117. PTHR10117. 1 hit.
PTHR10117:SF6. PTHR10117:SF6. 1 hit.
PfamiPF00520. Ion_trans. 1 hit.
[Graphical view]
PRINTSiPR01097. TRNSRECEPTRP.

Sequencei

Sequence statusi: Fragment.

Q61057-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
DDMIRFMFIL MIILTAFLCG LNNIYVPYQE SEKLGNFNET FQFLFWTMFG
60 70 80 90 100
MEEHTVVDMP QFLVPEFVGR AMYGIFTIVM VIVLLNMLIA MITNSFQKIE

DDADV
Length:105
Mass (Da):12,283
Last modified:November 1, 1996 - v1
Checksum:iB6176F90E086A253
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Non-terminal residuei1 – 11Imported
Non-terminal residuei105 – 1051Imported

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U40981 mRNA. Translation: AAC52700.1.
UniGeneiMm.292904.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U40981 mRNA. Translation: AAC52700.1.
UniGeneiMm.292904.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000081903.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Organism-specific databases

MGIiMGI:109527. Trpc2.

Miscellaneous databases

SOURCEiSearch...

Gene expression databases

BgeeiQ61057.
ExpressionAtlasiQ61057. baseline.

Family and domain databases

InterProiIPR005821. Ion_trans_dom.
IPR005458. TRPC2_channel.
IPR002153. TRPC_channel.
[Graphical view]
PANTHERiPTHR10117. PTHR10117. 1 hit.
PTHR10117:SF6. PTHR10117:SF6. 1 hit.
PfamiPF00520. Ion_trans. 1 hit.
[Graphical view]
PRINTSiPR01097. TRNSRECEPTRP.
ProtoNetiSearch...

Publicationsi

  1. "trp, a novel mammalian gene family essential for agonist-activated capacitative Ca2+ entry."
    Zhu X., Jiang M., Peyton M., Boulay G., Hurst R., Stefani E., Birnbaumer L.
    Cell 85:661-671(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.

Entry informationi

Entry nameiQ61057_MOUSE
AccessioniPrimary (citable) accession number: Q61057
Entry historyi
Integrated into UniProtKB/TrEMBL: November 1, 1996
Last sequence update: November 1, 1996
Last modified: June 24, 2015
This is version 70 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.