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Q61056

- TRPC1_MOUSE

UniProt

Q61056 - TRPC1_MOUSE

Protein

Short transient receptor potential channel 1

Gene

Trpc1

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 133 (01 Oct 2014)
      Sequence version 5 (03 May 2011)
      Previous versions | rss
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    Functioni

    Thought to form a receptor-activated non-selective calcium permeant cation channel. Probably is operated by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases or G-protein coupled receptors. Seems to be also activated by intracellular calcium store depletion.

    GO - Molecular functioni

    1. inositol 1,4,5 trisphosphate binding Source: Ensembl
    2. protein binding Source: MGI
    3. store-operated calcium channel activity Source: MGI

    GO - Biological processi

    1. cytosolic calcium ion homeostasis Source: Ensembl
    2. positive regulation of release of sequestered calcium ion into cytosol Source: Ensembl
    3. response to calcium ion Source: Ensembl
    4. saliva secretion Source: MGI

    Keywords - Molecular functioni

    Calcium channel, Ion channel

    Keywords - Biological processi

    Calcium transport, Ion transport, Transport

    Keywords - Ligandi

    Calcium

    Enzyme and pathway databases

    ReactomeiREACT_188194. Antigen activates B Cell Receptor (BCR) leading to generation of second messengers.
    REACT_227861. TRP channels.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Short transient receptor potential channel 1
    Short name:
    TrpC1
    Alternative name(s):
    Transient receptor protein 1
    Short name:
    TRP-1
    Short name:
    mTrp1
    Trp-related protein 1
    Gene namesi
    Name:Trpc1
    Synonyms:Trp1, Trrp1
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Unplaced

    Organism-specific databases

    MGIiMGI:109528. Trpc1.

    Subcellular locationi

    GO - Cellular componenti

    1. basolateral plasma membrane Source: MGI
    2. costamere Source: MGI
    3. cytoplasm Source: MGI
    4. integral component of membrane Source: UniProtKB-KW
    5. membrane raft Source: MGI
    6. protein complex Source: MGI
    7. receptor complex Source: MGI
    8. sarcomere Source: MGI

    Keywords - Cellular componenti

    Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 793793Short transient receptor potential channel 1PRO_0000215304Add
    BLAST

    Post-translational modificationi

    Activation of PRKCA induces phosphorylation of TRPC1 and subsequent Ca2+ entry into cells.By similarity

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    PRIDEiQ61056.

    PTM databases

    PhosphoSiteiQ61056.

    Expressioni

    Gene expression databases

    ArrayExpressiQ61056.
    BgeeiQ61056.
    GenevestigatoriQ61056.

    Interactioni

    Subunit structurei

    Homotetramer and heterotetramer with TRPC4 and/or TRPC5 By similarity. Interacts with TRPC3, TRPC4 and TRPC5 By similarity. Interacts with ITPR3 By similarity. Interacts with MX1 and RNF24 By similarity. Interacts with FKBP4 By similarity. Interacts with TRPC4AP.By similarity1 Publication

    Protein-protein interaction databases

    BioGridi204327. 2 interactions.
    IntActiQ61056. 1 interaction.
    MINTiMINT-4997241.

    Structurei

    3D structure databases

    ProteinModelPortaliQ61056.
    SMRiQ61056. Positions 51-186, 619-659.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 386386CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini408 – 4158ExtracellularSequence Analysis
    Topological domaini437 – 49559CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini517 – 53923ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini561 – 58626CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini608 – 6169ExtracellularSequence Analysis
    Topological domaini638 – 793156CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei387 – 40721HelicalSequence AnalysisAdd
    BLAST
    Transmembranei416 – 43621HelicalSequence AnalysisAdd
    BLAST
    Transmembranei496 – 51621HelicalSequence AnalysisAdd
    BLAST
    Transmembranei540 – 56021HelicalSequence AnalysisAdd
    BLAST
    Transmembranei587 – 60721HelicalSequence AnalysisAdd
    BLAST
    Transmembranei617 – 63721HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Repeati46 – 7530ANK 1Add
    BLAST
    Repeati83 – 11129ANK 2Add
    BLAST
    Repeati112 – 13827ANK 3Add
    BLAST
    Repeati158 – 18730ANK 4Add
    BLAST

    Sequence similaritiesi

    Contains 4 ANK repeats.Curated

    Keywords - Domaini

    ANK repeat, Repeat, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG245138.
    HOGENOMiHOG000020589.
    HOVERGENiHBG068337.
    InParanoidiQ61056.
    KOiK04964.

    Family and domain databases

    Gene3Di1.25.40.20. 1 hit.
    InterProiIPR002110. Ankyrin_rpt.
    IPR020683. Ankyrin_rpt-contain_dom.
    IPR005821. Ion_trans_dom.
    IPR004729. TRP_channel.
    IPR013555. TRP_dom.
    IPR005457. TRPC1_channel.
    IPR002153. TRPC_channel.
    [Graphical view]
    PANTHERiPTHR10117. PTHR10117. 1 hit.
    PTHR10117:SF3. PTHR10117:SF3. 1 hit.
    PfamiPF12796. Ank_2. 1 hit.
    PF00520. Ion_trans. 1 hit.
    PF08344. TRP_2. 1 hit.
    [Graphical view]
    PRINTSiPR01097. TRNSRECEPTRP.
    PR01642. TRPCHANNEL1.
    SMARTiSM00248. ANK. 3 hits.
    [Graphical view]
    SUPFAMiSSF48403. SSF48403. 1 hit.
    TIGRFAMsiTIGR00870. trp. 1 hit.

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform Alpha (identifier: Q61056-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MMAALYPSTD LSGVSSSSLP SSPSSSSPNE VMALKDVREV KEENTLNEKL    50
    FLLACDKGDY YMVKKILEEN SSGDLNINCV DVLGRNAVTI TIENESLDIL 100
    QLLLDYGCQS ADALLVAIDS EVVGAVDILL NHRPKRSSRP TIVKLMERIQ 150
    NPEYSTTMDV APVILAAHRN NYEILTMLLK QDVSLPKPHA VGCECTLCSA 200
    KNKKDSLRHS RFRLDIYRCL ASPALIMLTE EDPILRAFEL SADLKELSLV 250
    EVEFRNDYEE LARQCKMFAK DLLAQARNSR ELEVILNHTS SDEPLDKRGL 300
    LEERMNLSRL KLAIKYNQKE FVSQSNCQQF LNTVWFGQMS GYRRKPTCKK 350
    IMTVLTVGIF WPVLSLCYLI APKSQFGRII HTPFMKFIIH GASYFTFLLL 400
    LNLYSLVYNE DKKNTMGPAL ERIDYLLILW IIGMIWSDIK RLWYEGLEDF 450
    LEESRNQLSF VMNSLYLATF ALKVVAHNKF HDFADRKDWD AFHPTLVAEG 500
    LFAFANVLSY LRLFFMYTTS SILGPLQISM GQMLQDFGKF LGMFLLVLFS 550
    FTIGLTQLYD KGYTSKEQKD CVGIFCEQQS NDTFHSFIGT CFALFWYIFS 600
    LAHVAIFVTR FSYGEELQSF VGAVIVGTYN VVVVIVLTKL LVAMLHKSFQ 650
    LIANHEDKEW KFARAKLWLS YFDDKCTLPP PFNIIPSPKT ICYMISSLSK 700
    WICSHTSKGK VKRQNSLKEW RNLKQKRDEN YQKVMCCLVH RYLTSMRQKM 750
    QSTDQATVEN LNELRQDLSK FRNEIRDLLG FRTSKYAMFY PRN 793
    Length:793
    Mass (Da):91,213
    Last modified:May 3, 2011 - v5
    Checksum:iCBECB08C0D72E5DF
    GO
    Isoform Beta (identifier: Q61056-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         110-143: Missing.

    Show »
    Length:759
    Mass (Da):87,618
    Checksum:i92FFA669703237BE
    GO

    Sequence cautioni

    The sequence AAB50622.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.
    The sequence AAC53162.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.
    The sequence AAF05725.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei110 – 14334Missing in isoform Beta. 1 PublicationVSP_006561Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U73625 mRNA. Translation: AAB50622.1. Different initiation.
    U95167 mRNA. Translation: AAC53162.1. Different initiation.
    AF191551 mRNA. Translation: AAF05725.1. Different initiation.
    U40980 mRNA. Translation: AAC52699.1.
    RefSeqiNP_035773.1. NM_011643.2.
    XP_006511117.1. XM_006511054.1.
    UniGeneiMm.149633.

    Genome annotation databases

    GeneIDi22063.
    KEGGimmu:22063.
    UCSCiuc009rbj.1. mouse. [Q61056-1]

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U73625 mRNA. Translation: AAB50622.1 . Different initiation.
    U95167 mRNA. Translation: AAC53162.1 . Different initiation.
    AF191551 mRNA. Translation: AAF05725.1 . Different initiation.
    U40980 mRNA. Translation: AAC52699.1 .
    RefSeqi NP_035773.1. NM_011643.2.
    XP_006511117.1. XM_006511054.1.
    UniGenei Mm.149633.

    3D structure databases

    ProteinModelPortali Q61056.
    SMRi Q61056. Positions 51-186, 619-659.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 204327. 2 interactions.
    IntActi Q61056. 1 interaction.
    MINTi MINT-4997241.

    PTM databases

    PhosphoSitei Q61056.

    Proteomic databases

    PRIDEi Q61056.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 22063.
    KEGGi mmu:22063.
    UCSCi uc009rbj.1. mouse. [Q61056-1 ]

    Organism-specific databases

    CTDi 7220.
    MGIi MGI:109528. Trpc1.

    Phylogenomic databases

    eggNOGi NOG245138.
    HOGENOMi HOG000020589.
    HOVERGENi HBG068337.
    InParanoidi Q61056.
    KOi K04964.

    Enzyme and pathway databases

    Reactomei REACT_188194. Antigen activates B Cell Receptor (BCR) leading to generation of second messengers.
    REACT_227861. TRP channels.

    Miscellaneous databases

    NextBioi 301872.
    PROi Q61056.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q61056.
    Bgeei Q61056.
    Genevestigatori Q61056.

    Family and domain databases

    Gene3Di 1.25.40.20. 1 hit.
    InterProi IPR002110. Ankyrin_rpt.
    IPR020683. Ankyrin_rpt-contain_dom.
    IPR005821. Ion_trans_dom.
    IPR004729. TRP_channel.
    IPR013555. TRP_dom.
    IPR005457. TRPC1_channel.
    IPR002153. TRPC_channel.
    [Graphical view ]
    PANTHERi PTHR10117. PTHR10117. 1 hit.
    PTHR10117:SF3. PTHR10117:SF3. 1 hit.
    Pfami PF12796. Ank_2. 1 hit.
    PF00520. Ion_trans. 1 hit.
    PF08344. TRP_2. 1 hit.
    [Graphical view ]
    PRINTSi PR01097. TRNSRECEPTRP.
    PR01642. TRPCHANNEL1.
    SMARTi SM00248. ANK. 3 hits.
    [Graphical view ]
    SUPFAMi SSF48403. SSF48403. 1 hit.
    TIGRFAMsi TIGR00870. trp. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Identification of four trp1 gene variants murine pancreatic beta-cells."
      Sakura H., Ashcroft F.M.
      Diabetologia 40:528-532(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], ALTERNATIVE SPLICING.
      Tissue: Insulinoma.
    2. "Ion channels in lens epithelia."
      Rae J.L.
      Submitted (OCT-1999) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM BETA).
      Tissue: Lens epithelium.
    3. "trp, a novel mammalian gene family essential for agonist-activated capacitative Ca2+ entry."
      Zhu X., Jiang M., Peyton M., Boulay G., Hurst R., Stefani E., Birnbaumer L.
      Cell 85:661-671(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 535-658.
    4. "TRUSS, TNF-R1, and TRPC ion channels synergistically reverse endoplasmic reticulum Ca2+ storage reduction in response to m1 muscarinic acetylcholine receptor signaling."
      Mace K.E., Lussier M.P., Boulay G., Terry-Powers J.L., Parfrey H., Perraud A.L., Riches D.W.H.
      J. Cell. Physiol. 225:444-453(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH TRPC4AP.

    Entry informationi

    Entry nameiTRPC1_MOUSE
    AccessioniPrimary (citable) accession number: Q61056
    Secondary accession number(s): O35722
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 1, 2000
    Last sequence update: May 3, 2011
    Last modified: October 1, 2014
    This is version 133 of the entry and version 5 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3