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Q61056

- TRPC1_MOUSE

UniProt

Q61056 - TRPC1_MOUSE

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Protein
Short transient receptor potential channel 1
Gene
Trpc1, Trp1, Trrp1
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Thought to form a receptor-activated non-selective calcium permeant cation channel. Probably is operated by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases or G-protein coupled receptors. Seems to be also activated by intracellular calcium store depletion.

GO - Molecular functioni

  1. inositol 1,4,5 trisphosphate binding Source: Ensembl
  2. protein binding Source: MGI
  3. store-operated calcium channel activity Source: MGI
Complete GO annotation...

GO - Biological processi

  1. cytosolic calcium ion homeostasis Source: Ensembl
  2. positive regulation of release of sequestered calcium ion into cytosol Source: Ensembl
  3. response to calcium ion Source: Ensembl
  4. saliva secretion Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

Calcium channel, Ion channel

Keywords - Biological processi

Calcium transport, Ion transport, Transport

Keywords - Ligandi

Calcium

Enzyme and pathway databases

ReactomeiREACT_188194. Antigen activates B Cell Receptor (BCR) leading to generation of second messengers.
REACT_227861. TRP channels.

Names & Taxonomyi

Protein namesi
Recommended name:
Short transient receptor potential channel 1
Short name:
TrpC1
Alternative name(s):
Transient receptor protein 1
Short name:
TRP-1
Short name:
mTrp1
Trp-related protein 1
Gene namesi
Name:Trpc1
Synonyms:Trp1, Trrp1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Unplaced

Organism-specific databases

MGIiMGI:109528. Trpc1.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 386386Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei387 – 40721Helical; Reviewed prediction
Add
BLAST
Topological domaini408 – 4158Extracellular Reviewed prediction
Transmembranei416 – 43621Helical; Reviewed prediction
Add
BLAST
Topological domaini437 – 49559Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei496 – 51621Helical; Reviewed prediction
Add
BLAST
Topological domaini517 – 53923Extracellular Reviewed prediction
Add
BLAST
Transmembranei540 – 56021Helical; Reviewed prediction
Add
BLAST
Topological domaini561 – 58626Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei587 – 60721Helical; Reviewed prediction
Add
BLAST
Topological domaini608 – 6169Extracellular Reviewed prediction
Transmembranei617 – 63721Helical; Reviewed prediction
Add
BLAST
Topological domaini638 – 793156Cytoplasmic Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. basolateral plasma membrane Source: MGI
  2. costamere Source: MGI
  3. cytoplasm Source: MGI
  4. integral component of membrane Source: UniProtKB-KW
  5. membrane raft Source: MGI
  6. protein complex Source: MGI
  7. receptor complex Source: MGI
  8. sarcomere Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 793793Short transient receptor potential channel 1
PRO_0000215304Add
BLAST

Post-translational modificationi

Activation of PRKCA induces phosphorylation of TRPC1 and subsequent Ca2+ entry into cells By similarity.

Keywords - PTMi

Phosphoprotein

Proteomic databases

PRIDEiQ61056.

PTM databases

PhosphoSiteiQ61056.

Expressioni

Gene expression databases

ArrayExpressiQ61056.
BgeeiQ61056.
GenevestigatoriQ61056.

Interactioni

Subunit structurei

Homotetramer and heterotetramer with TRPC4 and/or TRPC5 By similarity. Interacts with TRPC3, TRPC4 and TRPC5 By similarity. Interacts with ITPR3 By similarity. Interacts with MX1 and RNF24 By similarity. Interacts with FKBP4 By similarity. Interacts with TRPC4AP.1 Publication

Protein-protein interaction databases

BioGridi204327. 2 interactions.
IntActiQ61056. 1 interaction.
MINTiMINT-4997241.

Structurei

3D structure databases

ProteinModelPortaliQ61056.
SMRiQ61056. Positions 51-186, 619-659.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati46 – 7530ANK 1
Add
BLAST
Repeati83 – 11129ANK 2
Add
BLAST
Repeati112 – 13827ANK 3
Add
BLAST
Repeati158 – 18730ANK 4
Add
BLAST

Sequence similaritiesi

Contains 4 ANK repeats.

Keywords - Domaini

ANK repeat, Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG245138.
HOGENOMiHOG000020589.
HOVERGENiHBG068337.
InParanoidiQ61056.
KOiK04964.

Family and domain databases

Gene3Di1.25.40.20. 1 hit.
InterProiIPR002110. Ankyrin_rpt.
IPR020683. Ankyrin_rpt-contain_dom.
IPR005821. Ion_trans_dom.
IPR004729. TRP_channel.
IPR013555. TRP_dom.
IPR005457. TRPC1_channel.
IPR002153. TRPC_channel.
[Graphical view]
PANTHERiPTHR10117. PTHR10117. 1 hit.
PTHR10117:SF3. PTHR10117:SF3. 1 hit.
PfamiPF12796. Ank_2. 1 hit.
PF00520. Ion_trans. 1 hit.
PF08344. TRP_2. 1 hit.
[Graphical view]
PRINTSiPR01097. TRNSRECEPTRP.
PR01642. TRPCHANNEL1.
SMARTiSM00248. ANK. 3 hits.
[Graphical view]
SUPFAMiSSF48403. SSF48403. 1 hit.
TIGRFAMsiTIGR00870. trp. 1 hit.

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform Alpha (identifier: Q61056-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MMAALYPSTD LSGVSSSSLP SSPSSSSPNE VMALKDVREV KEENTLNEKL    50
FLLACDKGDY YMVKKILEEN SSGDLNINCV DVLGRNAVTI TIENESLDIL 100
QLLLDYGCQS ADALLVAIDS EVVGAVDILL NHRPKRSSRP TIVKLMERIQ 150
NPEYSTTMDV APVILAAHRN NYEILTMLLK QDVSLPKPHA VGCECTLCSA 200
KNKKDSLRHS RFRLDIYRCL ASPALIMLTE EDPILRAFEL SADLKELSLV 250
EVEFRNDYEE LARQCKMFAK DLLAQARNSR ELEVILNHTS SDEPLDKRGL 300
LEERMNLSRL KLAIKYNQKE FVSQSNCQQF LNTVWFGQMS GYRRKPTCKK 350
IMTVLTVGIF WPVLSLCYLI APKSQFGRII HTPFMKFIIH GASYFTFLLL 400
LNLYSLVYNE DKKNTMGPAL ERIDYLLILW IIGMIWSDIK RLWYEGLEDF 450
LEESRNQLSF VMNSLYLATF ALKVVAHNKF HDFADRKDWD AFHPTLVAEG 500
LFAFANVLSY LRLFFMYTTS SILGPLQISM GQMLQDFGKF LGMFLLVLFS 550
FTIGLTQLYD KGYTSKEQKD CVGIFCEQQS NDTFHSFIGT CFALFWYIFS 600
LAHVAIFVTR FSYGEELQSF VGAVIVGTYN VVVVIVLTKL LVAMLHKSFQ 650
LIANHEDKEW KFARAKLWLS YFDDKCTLPP PFNIIPSPKT ICYMISSLSK 700
WICSHTSKGK VKRQNSLKEW RNLKQKRDEN YQKVMCCLVH RYLTSMRQKM 750
QSTDQATVEN LNELRQDLSK FRNEIRDLLG FRTSKYAMFY PRN 793
Length:793
Mass (Da):91,213
Last modified:May 3, 2011 - v5
Checksum:iCBECB08C0D72E5DF
GO
Isoform Beta (identifier: Q61056-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     110-143: Missing.

Show »
Length:759
Mass (Da):87,618
Checksum:i92FFA669703237BE
GO

Sequence cautioni

The sequence AAB50622.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.
The sequence AAC53162.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.
The sequence AAF05725.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei110 – 14334Missing in isoform Beta.
VSP_006561Add
BLAST

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U73625 mRNA. Translation: AAB50622.1. Different initiation.
U95167 mRNA. Translation: AAC53162.1. Different initiation.
AF191551 mRNA. Translation: AAF05725.1. Different initiation.
U40980 mRNA. Translation: AAC52699.1.
RefSeqiNP_035773.1. NM_011643.2.
XP_006511117.1. XM_006511054.1.
UniGeneiMm.149633.

Genome annotation databases

GeneIDi22063.
KEGGimmu:22063.
UCSCiuc009rbj.1. mouse. [Q61056-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U73625 mRNA. Translation: AAB50622.1 . Different initiation.
U95167 mRNA. Translation: AAC53162.1 . Different initiation.
AF191551 mRNA. Translation: AAF05725.1 . Different initiation.
U40980 mRNA. Translation: AAC52699.1 .
RefSeqi NP_035773.1. NM_011643.2.
XP_006511117.1. XM_006511054.1.
UniGenei Mm.149633.

3D structure databases

ProteinModelPortali Q61056.
SMRi Q61056. Positions 51-186, 619-659.
ModBasei Search...

Protein-protein interaction databases

BioGridi 204327. 2 interactions.
IntActi Q61056. 1 interaction.
MINTi MINT-4997241.

PTM databases

PhosphoSitei Q61056.

Proteomic databases

PRIDEi Q61056.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 22063.
KEGGi mmu:22063.
UCSCi uc009rbj.1. mouse. [Q61056-1 ]

Organism-specific databases

CTDi 7220.
MGIi MGI:109528. Trpc1.

Phylogenomic databases

eggNOGi NOG245138.
HOGENOMi HOG000020589.
HOVERGENi HBG068337.
InParanoidi Q61056.
KOi K04964.

Enzyme and pathway databases

Reactomei REACT_188194. Antigen activates B Cell Receptor (BCR) leading to generation of second messengers.
REACT_227861. TRP channels.

Miscellaneous databases

NextBioi 301872.
PROi Q61056.
SOURCEi Search...

Gene expression databases

ArrayExpressi Q61056.
Bgeei Q61056.
Genevestigatori Q61056.

Family and domain databases

Gene3Di 1.25.40.20. 1 hit.
InterProi IPR002110. Ankyrin_rpt.
IPR020683. Ankyrin_rpt-contain_dom.
IPR005821. Ion_trans_dom.
IPR004729. TRP_channel.
IPR013555. TRP_dom.
IPR005457. TRPC1_channel.
IPR002153. TRPC_channel.
[Graphical view ]
PANTHERi PTHR10117. PTHR10117. 1 hit.
PTHR10117:SF3. PTHR10117:SF3. 1 hit.
Pfami PF12796. Ank_2. 1 hit.
PF00520. Ion_trans. 1 hit.
PF08344. TRP_2. 1 hit.
[Graphical view ]
PRINTSi PR01097. TRNSRECEPTRP.
PR01642. TRPCHANNEL1.
SMARTi SM00248. ANK. 3 hits.
[Graphical view ]
SUPFAMi SSF48403. SSF48403. 1 hit.
TIGRFAMsi TIGR00870. trp. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Identification of four trp1 gene variants murine pancreatic beta-cells."
    Sakura H., Ashcroft F.M.
    Diabetologia 40:528-532(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], ALTERNATIVE SPLICING.
    Tissue: Insulinoma.
  2. "Ion channels in lens epithelia."
    Rae J.L.
    Submitted (OCT-1999) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM BETA).
    Tissue: Lens epithelium.
  3. "trp, a novel mammalian gene family essential for agonist-activated capacitative Ca2+ entry."
    Zhu X., Jiang M., Peyton M., Boulay G., Hurst R., Stefani E., Birnbaumer L.
    Cell 85:661-671(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 535-658.
  4. "TRUSS, TNF-R1, and TRPC ion channels synergistically reverse endoplasmic reticulum Ca2+ storage reduction in response to m1 muscarinic acetylcholine receptor signaling."
    Mace K.E., Lussier M.P., Boulay G., Terry-Powers J.L., Parfrey H., Perraud A.L., Riches D.W.H.
    J. Cell. Physiol. 225:444-453(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH TRPC4AP.

Entry informationi

Entry nameiTRPC1_MOUSE
AccessioniPrimary (citable) accession number: Q61056
Secondary accession number(s): O35722
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: May 3, 2011
Last modified: September 3, 2014
This is version 132 of the entry and version 5 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi