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Protein

Short transient receptor potential channel 1

Gene

Trpc1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Thought to form a receptor-activated non-selective calcium permeant cation channel. Probably is operated by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases or G-protein coupled receptors. Seems to be also activated by intracellular calcium store depletion.

GO - Molecular functioni

  • cation channel activity Source: MGI
  • inositol 1,4,5 trisphosphate binding Source: MGI
  • store-operated calcium channel activity Source: MGI

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Calcium channel, Ion channel

Keywords - Biological processi

Calcium transport, Ion transport, Transport

Keywords - Ligandi

Calcium

Names & Taxonomyi

Protein namesi
Recommended name:
Short transient receptor potential channel 1
Short name:
TrpC1
Alternative name(s):
Transient receptor protein 1
Short name:
TRP-1
Short name:
mTrp1
Trp-related protein 1
Gene namesi
Name:Trpc1
Synonyms:Trp1, Trrp1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Unplaced

Organism-specific databases

MGIiMGI:109528. Trpc1.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 386CytoplasmicSequence analysisAdd BLAST386
Transmembranei387 – 407HelicalSequence analysisAdd BLAST21
Topological domaini408 – 415ExtracellularSequence analysis8
Transmembranei416 – 436HelicalSequence analysisAdd BLAST21
Topological domaini437 – 495CytoplasmicSequence analysisAdd BLAST59
Transmembranei496 – 516HelicalSequence analysisAdd BLAST21
Topological domaini517 – 539ExtracellularSequence analysisAdd BLAST23
Transmembranei540 – 560HelicalSequence analysisAdd BLAST21
Topological domaini561 – 586CytoplasmicSequence analysisAdd BLAST26
Transmembranei587 – 607HelicalSequence analysisAdd BLAST21
Topological domaini608 – 616ExtracellularSequence analysis9
Transmembranei617 – 637HelicalSequence analysisAdd BLAST21
Topological domaini638 – 793CytoplasmicSequence analysisAdd BLAST156

GO - Cellular componenti

  • basolateral plasma membrane Source: MGI
  • costamere Source: MGI
  • cytoplasm Source: MGI
  • integral component of plasma membrane Source: GO_Central
  • membrane raft Source: MGI
  • plasma membrane Source: MGI
  • protein complex Source: MGI
  • receptor complex Source: MGI
  • sarcomere Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002153041 – 793Short transient receptor potential channel 1Add BLAST793

Post-translational modificationi

Activation of PRKCA induces phosphorylation of TRPC1 and subsequent Ca2+ entry into cells.By similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ61056.
PRIDEiQ61056.

PTM databases

iPTMnetiQ61056.
PhosphoSitePlusiQ61056.

Expressioni

Gene expression databases

BgeeiENSMUSG00000032839.

Interactioni

Subunit structurei

Homotetramer and heterotetramer with TRPC4 and/or TRPC5 (By similarity). Interacts with TRPC3, TRPC4 and TRPC5 (By similarity). Interacts with ITPR3 (By similarity). Interacts with MX1 and RNF24 (By similarity). Interacts with FKBP4 (By similarity). Interacts with TRPC4AP.By similarity1 Publication

Protein-protein interaction databases

BioGridi204327. 2 interactors.
DIPiDIP-33928N.
IntActiQ61056. 1 interactor.
MINTiMINT-4997241.
STRINGi10090.ENSMUSP00000057640.

Structurei

3D structure databases

ProteinModelPortaliQ61056.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati46 – 75ANK 1Add BLAST30
Repeati83 – 111ANK 2Add BLAST29
Repeati112 – 138ANK 3Add BLAST27
Repeati158 – 187ANK 4Add BLAST30

Sequence similaritiesi

Contains 4 ANK repeats.Curated

Keywords - Domaini

ANK repeat, Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3609. Eukaryota.
ENOG410XQ0Y. LUCA.
HOGENOMiHOG000020589.
HOVERGENiHBG068337.
InParanoidiQ61056.
KOiK04964.

Family and domain databases

Gene3Di1.25.40.20. 1 hit.
InterProiIPR002110. Ankyrin_rpt.
IPR020683. Ankyrin_rpt-contain_dom.
IPR005821. Ion_trans_dom.
IPR004729. TRP_channel.
IPR013555. TRP_dom.
IPR005457. TRPC1_channel.
IPR002153. TRPC_channel.
[Graphical view]
PANTHERiPTHR10117. PTHR10117. 1 hit.
PfamiPF00520. Ion_trans. 1 hit.
PF08344. TRP_2. 1 hit.
[Graphical view]
PRINTSiPR01097. TRNSRECEPTRP.
PR01642. TRPCHANNEL1.
SMARTiSM00248. ANK. 3 hits.
[Graphical view]
SUPFAMiSSF48403. SSF48403. 1 hit.
TIGRFAMsiTIGR00870. trp. 1 hit.

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform Alpha (identifier: Q61056-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MMAALYPSTD LSGVSSSSLP SSPSSSSPNE VMALKDVREV KEENTLNEKL
60 70 80 90 100
FLLACDKGDY YMVKKILEEN SSGDLNINCV DVLGRNAVTI TIENESLDIL
110 120 130 140 150
QLLLDYGCQS ADALLVAIDS EVVGAVDILL NHRPKRSSRP TIVKLMERIQ
160 170 180 190 200
NPEYSTTMDV APVILAAHRN NYEILTMLLK QDVSLPKPHA VGCECTLCSA
210 220 230 240 250
KNKKDSLRHS RFRLDIYRCL ASPALIMLTE EDPILRAFEL SADLKELSLV
260 270 280 290 300
EVEFRNDYEE LARQCKMFAK DLLAQARNSR ELEVILNHTS SDEPLDKRGL
310 320 330 340 350
LEERMNLSRL KLAIKYNQKE FVSQSNCQQF LNTVWFGQMS GYRRKPTCKK
360 370 380 390 400
IMTVLTVGIF WPVLSLCYLI APKSQFGRII HTPFMKFIIH GASYFTFLLL
410 420 430 440 450
LNLYSLVYNE DKKNTMGPAL ERIDYLLILW IIGMIWSDIK RLWYEGLEDF
460 470 480 490 500
LEESRNQLSF VMNSLYLATF ALKVVAHNKF HDFADRKDWD AFHPTLVAEG
510 520 530 540 550
LFAFANVLSY LRLFFMYTTS SILGPLQISM GQMLQDFGKF LGMFLLVLFS
560 570 580 590 600
FTIGLTQLYD KGYTSKEQKD CVGIFCEQQS NDTFHSFIGT CFALFWYIFS
610 620 630 640 650
LAHVAIFVTR FSYGEELQSF VGAVIVGTYN VVVVIVLTKL LVAMLHKSFQ
660 670 680 690 700
LIANHEDKEW KFARAKLWLS YFDDKCTLPP PFNIIPSPKT ICYMISSLSK
710 720 730 740 750
WICSHTSKGK VKRQNSLKEW RNLKQKRDEN YQKVMCCLVH RYLTSMRQKM
760 770 780 790
QSTDQATVEN LNELRQDLSK FRNEIRDLLG FRTSKYAMFY PRN
Length:793
Mass (Da):91,213
Last modified:May 3, 2011 - v5
Checksum:iCBECB08C0D72E5DF
GO
Isoform Beta (identifier: Q61056-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     110-143: Missing.

Show »
Length:759
Mass (Da):87,618
Checksum:i92FFA669703237BE
GO

Sequence cautioni

The sequence AAB50622 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated
The sequence AAC53162 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated
The sequence AAF05725 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_006561110 – 143Missing in isoform Beta. 1 PublicationAdd BLAST34

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U73625 mRNA. Translation: AAB50622.1. Different initiation.
U95167 mRNA. Translation: AAC53162.1. Different initiation.
AF191551 mRNA. Translation: AAF05725.1. Different initiation.
U40980 mRNA. Translation: AAC52699.1.
RefSeqiNP_001298052.1. NM_001311123.1.
NP_035773.1. NM_011643.3.
UniGeneiMm.149633.
Mm.398522.

Genome annotation databases

GeneIDi22063.
KEGGimmu:22063.
UCSCiuc009rbj.1. mouse. [Q61056-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U73625 mRNA. Translation: AAB50622.1. Different initiation.
U95167 mRNA. Translation: AAC53162.1. Different initiation.
AF191551 mRNA. Translation: AAF05725.1. Different initiation.
U40980 mRNA. Translation: AAC52699.1.
RefSeqiNP_001298052.1. NM_001311123.1.
NP_035773.1. NM_011643.3.
UniGeneiMm.149633.
Mm.398522.

3D structure databases

ProteinModelPortaliQ61056.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi204327. 2 interactors.
DIPiDIP-33928N.
IntActiQ61056. 1 interactor.
MINTiMINT-4997241.
STRINGi10090.ENSMUSP00000057640.

PTM databases

iPTMnetiQ61056.
PhosphoSitePlusiQ61056.

Proteomic databases

PaxDbiQ61056.
PRIDEiQ61056.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi22063.
KEGGimmu:22063.
UCSCiuc009rbj.1. mouse. [Q61056-1]

Organism-specific databases

CTDi7220.
MGIiMGI:109528. Trpc1.

Phylogenomic databases

eggNOGiKOG3609. Eukaryota.
ENOG410XQ0Y. LUCA.
HOGENOMiHOG000020589.
HOVERGENiHBG068337.
InParanoidiQ61056.
KOiK04964.

Miscellaneous databases

PROiQ61056.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000032839.

Family and domain databases

Gene3Di1.25.40.20. 1 hit.
InterProiIPR002110. Ankyrin_rpt.
IPR020683. Ankyrin_rpt-contain_dom.
IPR005821. Ion_trans_dom.
IPR004729. TRP_channel.
IPR013555. TRP_dom.
IPR005457. TRPC1_channel.
IPR002153. TRPC_channel.
[Graphical view]
PANTHERiPTHR10117. PTHR10117. 1 hit.
PfamiPF00520. Ion_trans. 1 hit.
PF08344. TRP_2. 1 hit.
[Graphical view]
PRINTSiPR01097. TRNSRECEPTRP.
PR01642. TRPCHANNEL1.
SMARTiSM00248. ANK. 3 hits.
[Graphical view]
SUPFAMiSSF48403. SSF48403. 1 hit.
TIGRFAMsiTIGR00870. trp. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiTRPC1_MOUSE
AccessioniPrimary (citable) accession number: Q61056
Secondary accession number(s): O35722
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: May 3, 2011
Last modified: November 2, 2016
This is version 155 of the entry and version 5 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.