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Q61056 (TRPC1_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified June 11, 2014. Version 131. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Short transient receptor potential channel 1

Short name=TrpC1
Alternative name(s):
Transient receptor protein 1
Short name=TRP-1
Short name=mTrp1
Trp-related protein 1
Gene names
Name:Trpc1
Synonyms:Trp1, Trrp1
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length793 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Thought to form a receptor-activated non-selective calcium permeant cation channel. Probably is operated by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases or G-protein coupled receptors. Seems to be also activated by intracellular calcium store depletion.

Subunit structure

Homotetramer and heterotetramer with TRPC4 and/or TRPC5 By similarity. Interacts with TRPC3, TRPC4 and TRPC5 By similarity. Interacts with ITPR3 By similarity. Interacts with MX1 and RNF24 By similarity. Interacts with FKBP4 By similarity. Interacts with TRPC4AP. Ref.4

Subcellular location

Membrane; Multi-pass membrane protein Probable.

Post-translational modification

Activation of PRKCA induces phosphorylation of TRPC1 and subsequent Ca2+ entry into cells By similarity.

Sequence similarities

Belongs to the transient receptor (TC 1.A.4) family. STrpC subfamily. TRPC1 sub-subfamily. [View classification]

Contains 4 ANK repeats.

Sequence caution

The sequence AAB50622.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.

The sequence AAC53162.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.

The sequence AAF05725.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.

Ontologies

Keywords
   Biological processCalcium transport
Ion transport
Transport
   Cellular componentMembrane
   Coding sequence diversityAlternative splicing
   DomainANK repeat
Repeat
Transmembrane
Transmembrane helix
   LigandCalcium
   Molecular functionCalcium channel
Ion channel
   PTMPhosphoprotein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processcytosolic calcium ion homeostasis

Inferred from electronic annotation. Source: Ensembl

positive regulation of release of sequestered calcium ion into cytosol

Inferred from electronic annotation. Source: Ensembl

response to calcium ion

Inferred from electronic annotation. Source: Ensembl

saliva secretion

Inferred from mutant phenotype PubMed 17956991. Source: MGI

   Cellular_componentbasolateral plasma membrane

Inferred from mutant phenotype PubMed 17956991. Source: MGI

costamere

Inferred from direct assay PubMed 18268005. Source: MGI

cytoplasm

Inferred from direct assay PubMed 15044151. Source: MGI

integral component of membrane

Inferred from electronic annotation. Source: UniProtKB-KW

membrane raft

Inferred from direct assay PubMed 17416589. Source: MGI

protein complex

Inferred from physical interaction PubMed 17416589. Source: MGI

receptor complex

Inferred from sequence orthology PubMed 23382219. Source: MGI

sarcomere

Inferred from direct assay PubMed 18268005. Source: MGI

   Molecular_functioninositol 1,4,5 trisphosphate binding

Inferred from electronic annotation. Source: Ensembl

protein binding

Inferred from physical interaction PubMed 17416589PubMed 18268005. Source: MGI

store-operated calcium channel activity

Inferred from mutant phenotype PubMed 17956991. Source: MGI

Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]
Isoform Alpha (identifier: Q61056-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform Beta (identifier: Q61056-2)

The sequence of this isoform differs from the canonical sequence as follows:
     110-143: Missing.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 793793Short transient receptor potential channel 1
PRO_0000215304

Regions

Topological domain1 – 386386Cytoplasmic Potential
Transmembrane387 – 40721Helical; Potential
Topological domain408 – 4158Extracellular Potential
Transmembrane416 – 43621Helical; Potential
Topological domain437 – 49559Cytoplasmic Potential
Transmembrane496 – 51621Helical; Potential
Topological domain517 – 53923Extracellular Potential
Transmembrane540 – 56021Helical; Potential
Topological domain561 – 58626Cytoplasmic Potential
Transmembrane587 – 60721Helical; Potential
Topological domain608 – 6169Extracellular Potential
Transmembrane617 – 63721Helical; Potential
Topological domain638 – 793156Cytoplasmic Potential
Repeat46 – 7530ANK 1
Repeat83 – 11129ANK 2
Repeat112 – 13827ANK 3
Repeat158 – 18730ANK 4

Natural variations

Alternative sequence110 – 14334Missing in isoform Beta.
VSP_006561

Sequences

Sequence LengthMass (Da)Tools
Isoform Alpha [UniParc].

Last modified May 3, 2011. Version 5.
Checksum: CBECB08C0D72E5DF

FASTA79391,213
        10         20         30         40         50         60 
MMAALYPSTD LSGVSSSSLP SSPSSSSPNE VMALKDVREV KEENTLNEKL FLLACDKGDY 

        70         80         90        100        110        120 
YMVKKILEEN SSGDLNINCV DVLGRNAVTI TIENESLDIL QLLLDYGCQS ADALLVAIDS 

       130        140        150        160        170        180 
EVVGAVDILL NHRPKRSSRP TIVKLMERIQ NPEYSTTMDV APVILAAHRN NYEILTMLLK 

       190        200        210        220        230        240 
QDVSLPKPHA VGCECTLCSA KNKKDSLRHS RFRLDIYRCL ASPALIMLTE EDPILRAFEL 

       250        260        270        280        290        300 
SADLKELSLV EVEFRNDYEE LARQCKMFAK DLLAQARNSR ELEVILNHTS SDEPLDKRGL 

       310        320        330        340        350        360 
LEERMNLSRL KLAIKYNQKE FVSQSNCQQF LNTVWFGQMS GYRRKPTCKK IMTVLTVGIF 

       370        380        390        400        410        420 
WPVLSLCYLI APKSQFGRII HTPFMKFIIH GASYFTFLLL LNLYSLVYNE DKKNTMGPAL 

       430        440        450        460        470        480 
ERIDYLLILW IIGMIWSDIK RLWYEGLEDF LEESRNQLSF VMNSLYLATF ALKVVAHNKF 

       490        500        510        520        530        540 
HDFADRKDWD AFHPTLVAEG LFAFANVLSY LRLFFMYTTS SILGPLQISM GQMLQDFGKF 

       550        560        570        580        590        600 
LGMFLLVLFS FTIGLTQLYD KGYTSKEQKD CVGIFCEQQS NDTFHSFIGT CFALFWYIFS 

       610        620        630        640        650        660 
LAHVAIFVTR FSYGEELQSF VGAVIVGTYN VVVVIVLTKL LVAMLHKSFQ LIANHEDKEW 

       670        680        690        700        710        720 
KFARAKLWLS YFDDKCTLPP PFNIIPSPKT ICYMISSLSK WICSHTSKGK VKRQNSLKEW 

       730        740        750        760        770        780 
RNLKQKRDEN YQKVMCCLVH RYLTSMRQKM QSTDQATVEN LNELRQDLSK FRNEIRDLLG 

       790 
FRTSKYAMFY PRN 

« Hide

Isoform Beta [UniParc].

Checksum: 92FFA669703237BE
Show »

FASTA75987,618

References

[1]"Identification of four trp1 gene variants murine pancreatic beta-cells."
Sakura H., Ashcroft F.M.
Diabetologia 40:528-532(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], ALTERNATIVE SPLICING.
Tissue: Insulinoma.
[2]"Ion channels in lens epithelia."
Rae J.L.
Submitted (OCT-1999) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM BETA).
Tissue: Lens epithelium.
[3]"trp, a novel mammalian gene family essential for agonist-activated capacitative Ca2+ entry."
Zhu X., Jiang M., Peyton M., Boulay G., Hurst R., Stefani E., Birnbaumer L.
Cell 85:661-671(1996) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 535-658.
[4]"TRUSS, TNF-R1, and TRPC ion channels synergistically reverse endoplasmic reticulum Ca2+ storage reduction in response to m1 muscarinic acetylcholine receptor signaling."
Mace K.E., Lussier M.P., Boulay G., Terry-Powers J.L., Parfrey H., Perraud A.L., Riches D.W.H.
J. Cell. Physiol. 225:444-453(2010) [PubMed] [Europe PMC] [Abstract]
Cited for: INTERACTION WITH TRPC4AP.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
U73625 mRNA. Translation: AAB50622.1. Different initiation.
U95167 mRNA. Translation: AAC53162.1. Different initiation.
AF191551 mRNA. Translation: AAF05725.1. Different initiation.
U40980 mRNA. Translation: AAC52699.1.
RefSeqNP_035773.1. NM_011643.2.
XP_006511117.1. XM_006511054.1.
UniGeneMm.149633.

3D structure databases

ProteinModelPortalQ61056.
SMRQ61056. Positions 51-186, 619-659.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid204327. 2 interactions.
IntActQ61056. 1 interaction.
MINTMINT-4997241.

PTM databases

PhosphoSiteQ61056.

Proteomic databases

PRIDEQ61056.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID22063.
KEGGmmu:22063.
UCSCuc009rbj.1. mouse. [Q61056-1]

Organism-specific databases

CTD7220.
MGIMGI:109528. Trpc1.

Phylogenomic databases

eggNOGNOG245138.
HOGENOMHOG000020589.
HOVERGENHBG068337.
InParanoidQ61056.
KOK04964.

Gene expression databases

ArrayExpressQ61056.
BgeeQ61056.
GenevestigatorQ61056.

Family and domain databases

Gene3D1.25.40.20. 1 hit.
InterProIPR002110. Ankyrin_rpt.
IPR020683. Ankyrin_rpt-contain_dom.
IPR005821. Ion_trans_dom.
IPR004729. TRP_channel.
IPR013555. TRP_dom.
IPR005457. TRPC1_channel.
IPR002153. TRPC_channel.
[Graphical view]
PANTHERPTHR10117. PTHR10117. 1 hit.
PTHR10117:SF3. PTHR10117:SF3. 1 hit.
PfamPF12796. Ank_2. 1 hit.
PF00520. Ion_trans. 1 hit.
PF08344. TRP_2. 1 hit.
[Graphical view]
PRINTSPR01097. TRNSRECEPTRP.
PR01642. TRPCHANNEL1.
SMARTSM00248. ANK. 3 hits.
[Graphical view]
SUPFAMSSF48403. SSF48403. 1 hit.
TIGRFAMsTIGR00870. trp. 1 hit.
ProtoNetSearch...

Other

NextBio301872.
PROQ61056.
SOURCESearch...

Entry information

Entry nameTRPC1_MOUSE
AccessionPrimary (citable) accession number: Q61056
Secondary accession number(s): O35722
Entry history
Integrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: May 3, 2011
Last modified: June 11, 2014
This is version 131 of the entry and version 5 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot