UniProtKB - Q61045 (SIM1_MOUSE)
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Protein
Single-minded homolog 1
Gene
Sim1
Organism
Mus musculus (Mouse)
Status
Functioni
Transcriptional factor that may have pleiotropic effects during embryogenesis and in the adult.
GO - Molecular functioni
- DNA binding Source: UniProtKB-KW
- protein heterodimerization activity Source: UniProtKB
- RNA polymerase II transcription factor activity, sequence-specific DNA binding Source: GO_Central
GO - Biological processi
- cell differentiation Source: UniProtKB-KW
- nervous system development Source: GO_Central
- regulation of transcription, DNA-templated Source: MGI
- regulation of transcription by RNA polymerase II Source: GO_Central
- transcription, DNA-templated Source: UniProtKB-KW
- ureteric bud development Source: UniProtKB
Keywordsi
Molecular function | Developmental protein, DNA-binding |
Biological process | Differentiation, Neurogenesis, Transcription, Transcription regulation |
Names & Taxonomyi
Protein namesi | Recommended name: Single-minded homolog 1Short name: mSIM1 |
Gene namesi | Name:Sim1 |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:98306 Sim1 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000127440 | 1 – 765 | Single-minded homolog 1Add BLAST | 765 |
Proteomic databases
PaxDbi | Q61045 |
PRIDEi | Q61045 |
PTM databases
iPTMneti | Q61045 |
PhosphoSitePlusi | Q61045 |
Expressioni
Tissue specificityi
Detected in lung, skeletal muscle and kidney. During fetal development it is found in the CNS, developing kidney, mesodermal and endodermal tissues, including developing somites, mesonephric duct, and foregut.
Gene expression databases
Bgeei | ENSMUSG00000019913 |
CleanExi | MM_SIM1 |
ExpressionAtlasi | Q61045 baseline and differential |
Genevisiblei | Q61045 MM |
Interactioni
Subunit structurei
Efficient DNA binding requires dimerization with another bHLH protein. Heterodimer of SIM1 and ARNT.1 Publication
Binary interactionsi
With | Entry | #Exp. | IntAct | Notes |
---|---|---|---|---|
Arnt | P53762 | 2 | EBI-78890,EBI-78852 |
GO - Molecular functioni
- protein heterodimerization activity Source: UniProtKB
Protein-protein interaction databases
CORUMi | Q61045 |
IntActi | Q61045 3 interactors. |
MINTi | Q61045 |
STRINGi | 10090.ENSMUSP00000020071 |
Structurei
3D structure databases
ProteinModelPortali | Q61045 |
SMRi | Q61045 |
ModBasei | Search... |
MobiDBi | Search... |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 1 – 53 | bHLHPROSITE-ProRule annotationAdd BLAST | 53 | |
Domaini | 77 – 147 | PAS 1PROSITE-ProRule annotationAdd BLAST | 71 | |
Domaini | 218 – 288 | PAS 2PROSITE-ProRule annotationAdd BLAST | 71 | |
Domaini | 292 – 335 | PACAdd BLAST | 44 | |
Domaini | 336 – 765 | Single-minded C-terminalPROSITE-ProRule annotationAdd BLAST | 430 |
Motif
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Motifi | 368 – 387 | Nuclear localization signalBy similarityAdd BLAST | 20 |
Keywords - Domaini
RepeatPhylogenomic databases
eggNOGi | KOG3559 Eukaryota ENOG410XY57 LUCA |
GeneTreei | ENSGT00760000118788 |
HOGENOMi | HOG000236298 |
HOVERGENi | HBG003936 |
InParanoidi | Q61045 |
KOi | K09100 |
OMAi | ISPNCFG |
OrthoDBi | EOG091G06FQ |
PhylomeDBi | Q61045 |
TreeFami | TF317772 |
Family and domain databases
CDDi | cd00083 HLH, 1 hit cd00130 PAS, 2 hits |
Gene3Di | 4.10.280.101 hit |
InterProi | View protein in InterPro IPR011598 bHLH_dom IPR036638 HLH_DNA-bd_sf IPR001610 PAC IPR000014 PAS IPR035965 PAS-like_dom_sf IPR013767 PAS_fold IPR013655 PAS_fold_3 IPR010578 SIM_C |
Pfami | View protein in Pfam PF00010 HLH, 1 hit PF00989 PAS, 1 hit PF08447 PAS_3, 1 hit PF06621 SIM_C, 1 hit |
SMARTi | View protein in SMART SM00353 HLH, 1 hit SM00086 PAC, 1 hit SM00091 PAS, 2 hits |
SUPFAMi | SSF47459 SSF47459, 1 hit SSF55785 SSF55785, 2 hits |
PROSITEi | View protein in PROSITE PS50888 BHLH, 1 hit PS50112 PAS, 2 hits PS51302 SIM_C, 1 hit |
i Sequence
Sequence statusi: Complete.
Q61045-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MKEKSKNAAR TRREKENSEF YELAKLLPLP SAITSQLDKA SIIRLTTSYL
60 70 80 90 100
KMRVVFPEGL GEAWGHTSRT SPLDNVGREL GSHLLQTLDG FIFVVAPDGK
110 120 130 140 150
IMYISETASV HLGLSQVELT GNSIYEYIHP ADHDEMTAVL TAHQPYHSHF
160 170 180 190 200
VQEYEIERSF FLRMKCVLAK RNAGLTCGGY KVIHCSGYLK IRQYSLDMSP
210 220 230 240 250
FDGCYQNVGL VAVGHSLPPS AVTEIKLHSN MFMFRASLDM KLIFLDSRVA
260 270 280 290 300
ELTGYEPQDL IEKTLYHHVH GCDTFHLRCA HHLLLVKGQV TTKYYRFLAK
310 320 330 340 350
QGGWVWVQSY ATIVHNSRSS RPHCIVSVNY VLTDTEYKGL QLSLDQISAS
360 370 380 390 400
KPTFSYTSSS TPTISDNRKG AKSRLSSSKS KSRTSPYPQY SGFHTERSES
410 420 430 440 450
DHDSQWGGSP LTDTASPQLL DPERPGSQHE LSCAYRQFPD RSSLCYGFAL
460 470 480 490 500
DHSRLVEDRH FHTQACEGGR CEAGRYFLGA PPTGRDPWWG SRAALPLTKA
510 520 530 540 550
SPESREAYEN SMPHITSIHR IHGRGHWDED SVVSSPDPGS ASESGDRYRT
560 570 580 590 600
EQYQNSPHEP SKIETLIRAT QQMIKEEENR LQLRKAPPDQ LASINGAGKK
610 620 630 640 650
HSLCFANYQQ PPPTGEVCHS SALASTSPCD HIQQREGKML SPHENDYDNS
660 670 680 690 700
PTALSRISSP SSDRITKSSL ILAKDYLHSD MSPHQTAGDH PAISPNCFGS
710 720 730 740 750
HRQYFDKHAY TLTGYALEHL YDSETIRNYS LGCNGSHFDV TSHLRMQPDP
760
AQGHKGTSVI ITNGS
Sequence cautioni
The sequence AAA91201 differs from that shown. Reason: Erroneous termination at position 697. Translated as Cys.Curated
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 133 | H → L in AAA91201 (PubMed:8812055).Curated | 1 | |
Sequence conflicti | 133 | H → L in AAC05481 (PubMed:8812055).Curated | 1 | |
Sequence conflicti | 176 | Missing in AAA91201 (PubMed:8812055).Curated | 1 | |
Sequence conflicti | 322 | P → R in AAA91201 (PubMed:8812055).Curated | 1 | |
Sequence conflicti | 322 | P → R in AAC05481 (PubMed:8812055).Curated | 1 | |
Sequence conflicti | 480 | A → P in AAA91201 (PubMed:8812055).Curated | 1 | |
Sequence conflicti | 537 | D → S in AAA91201 (PubMed:8812055).Curated | 1 | |
Sequence conflicti | 698 | F → K in AAA91201 (PubMed:8812055).Curated | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U40575 mRNA Translation: AAA91201.1 Sequence problems. AF038857 AF038855 Genomic DNA Translation: AAC05481.1 D79209 mRNA Translation: BAA11467.1 AB013491 Genomic DNA Translation: BAA28270.1 |
CCDSi | CCDS48556.1 |
RefSeqi | NP_035506.2, NM_011376.3 XP_006512690.1, XM_006512627.3 |
UniGenei | Mm.4774 |
Genome annotation databases
Ensembli | ENSMUST00000020071; ENSMUSP00000020071; ENSMUSG00000019913 |
GeneIDi | 20464 |
KEGGi | mmu:20464 |
UCSCi | uc007fal.1 mouse |
Similar proteinsi
Entry informationi
Entry namei | SIM1_MOUSE | |
Accessioni | Q61045Primary (citable) accession number: Q61045 Secondary accession number(s): O70284, P70183 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | November 1, 1997 |
Last sequence update: | July 15, 1999 | |
Last modified: | March 28, 2018 | |
This is version 155 of the entry and version 3 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |