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Q61045

- SIM1_MOUSE

UniProt

Q61045 - SIM1_MOUSE

Protein

Single-minded homolog 1

Gene

Sim1

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 130 (01 Oct 2014)
      Sequence version 3 (15 Jul 1999)
      Previous versions | rss
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    Functioni

    Transcriptional factor that may have pleiotropic effects during embryogenesis and in the adult.

    GO - Molecular functioni

    1. DNA binding Source: UniProtKB-KW
    2. protein binding Source: IntAct
    3. protein heterodimerization activity Source: UniProtKB
    4. sequence-specific DNA binding transcription factor activity Source: InterPro
    5. signal transducer activity Source: InterPro

    GO - Biological processi

    1. cell differentiation Source: UniProtKB-KW
    2. nervous system development Source: UniProtKB-KW
    3. regulation of transcription, DNA-templated Source: MGI
    4. transcription, DNA-templated Source: UniProtKB-KW
    5. ureteric bud development Source: UniProtKB

    Keywords - Molecular functioni

    Developmental protein

    Keywords - Biological processi

    Differentiation, Neurogenesis, Transcription, Transcription regulation

    Keywords - Ligandi

    DNA-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Single-minded homolog 1
    Short name:
    mSIM1
    Gene namesi
    Name:Sim1
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 10

    Organism-specific databases

    MGIiMGI:98306. Sim1.

    Subcellular locationi

    Nucleus PROSITE-ProRule annotation

    GO - Cellular componenti

    1. nucleus Source: MGI

    Keywords - Cellular componenti

    Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 765765Single-minded homolog 1PRO_0000127440Add
    BLAST

    Proteomic databases

    PRIDEiQ61045.

    PTM databases

    PhosphoSiteiQ61045.

    Expressioni

    Tissue specificityi

    Detected in lung, skeletal muscle and kidney. During fetal development it is found in the CNS, developing kidney, mesodermal and endodermal tissues, including developing somites, mesonephric duct, and foregut.

    Gene expression databases

    BgeeiQ61045.
    CleanExiMM_SIM1.
    GenevestigatoriQ61045.

    Interactioni

    Subunit structurei

    Efficient DNA binding requires dimerization with another bHLH protein. Heterodimer of SIM1 and ARNT.1 Publication

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    ArntP537622EBI-78890,EBI-78852

    Protein-protein interaction databases

    IntActiQ61045. 3 interactions.

    Structurei

    3D structure databases

    ProteinModelPortaliQ61045.
    SMRiQ61045. Positions 2-333.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini1 – 5353bHLHPROSITE-ProRule annotationAdd
    BLAST
    Domaini77 – 14771PAS 1PROSITE-ProRule annotationAdd
    BLAST
    Domaini218 – 28871PAS 2PROSITE-ProRule annotationAdd
    BLAST
    Domaini292 – 33544PACAdd
    BLAST
    Domaini336 – 765430Single-minded C-terminalPROSITE-ProRule annotationAdd
    BLAST

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi368 – 38720Nuclear localization signalBy similarityAdd
    BLAST

    Sequence similaritiesi

    Contains 1 bHLH (basic helix-loop-helix) domain.PROSITE-ProRule annotation
    Contains 2 PAS (PER-ARNT-SIM) domains.PROSITE-ProRule annotation
    Contains 1 Single-minded C-terminal domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Repeat

    Phylogenomic databases

    eggNOGiNOG310284.
    GeneTreeiENSGT00730000110507.
    HOGENOMiHOG000236298.
    HOVERGENiHBG003936.
    InParanoidiQ61045.
    KOiK09100.
    OMAiGEVCHSS.
    OrthoDBiEOG790G0R.
    PhylomeDBiQ61045.
    TreeFamiTF317772.

    Family and domain databases

    Gene3Di4.10.280.10. 1 hit.
    InterProiIPR011598. bHLH_dom.
    IPR001610. PAC.
    IPR000014. PAS.
    IPR013767. PAS_fold.
    IPR013655. PAS_fold_3.
    IPR010578. SIM_C.
    [Graphical view]
    PfamiPF00010. HLH. 1 hit.
    PF00989. PAS. 1 hit.
    PF08447. PAS_3. 1 hit.
    PF06621. SIM_C. 1 hit.
    [Graphical view]
    SMARTiSM00353. HLH. 1 hit.
    SM00086. PAC. 1 hit.
    SM00091. PAS. 2 hits.
    [Graphical view]
    SUPFAMiSSF47459. SSF47459. 1 hit.
    SSF55785. SSF55785. 2 hits.
    PROSITEiPS50888. BHLH. 1 hit.
    PS50112. PAS. 2 hits.
    PS51302. SIM_C. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q61045-1 [UniParc]FASTAAdd to Basket

    « Hide

    MKEKSKNAAR TRREKENSEF YELAKLLPLP SAITSQLDKA SIIRLTTSYL    50
    KMRVVFPEGL GEAWGHTSRT SPLDNVGREL GSHLLQTLDG FIFVVAPDGK 100
    IMYISETASV HLGLSQVELT GNSIYEYIHP ADHDEMTAVL TAHQPYHSHF 150
    VQEYEIERSF FLRMKCVLAK RNAGLTCGGY KVIHCSGYLK IRQYSLDMSP 200
    FDGCYQNVGL VAVGHSLPPS AVTEIKLHSN MFMFRASLDM KLIFLDSRVA 250
    ELTGYEPQDL IEKTLYHHVH GCDTFHLRCA HHLLLVKGQV TTKYYRFLAK 300
    QGGWVWVQSY ATIVHNSRSS RPHCIVSVNY VLTDTEYKGL QLSLDQISAS 350
    KPTFSYTSSS TPTISDNRKG AKSRLSSSKS KSRTSPYPQY SGFHTERSES 400
    DHDSQWGGSP LTDTASPQLL DPERPGSQHE LSCAYRQFPD RSSLCYGFAL 450
    DHSRLVEDRH FHTQACEGGR CEAGRYFLGA PPTGRDPWWG SRAALPLTKA 500
    SPESREAYEN SMPHITSIHR IHGRGHWDED SVVSSPDPGS ASESGDRYRT 550
    EQYQNSPHEP SKIETLIRAT QQMIKEEENR LQLRKAPPDQ LASINGAGKK 600
    HSLCFANYQQ PPPTGEVCHS SALASTSPCD HIQQREGKML SPHENDYDNS 650
    PTALSRISSP SSDRITKSSL ILAKDYLHSD MSPHQTAGDH PAISPNCFGS 700
    HRQYFDKHAY TLTGYALEHL YDSETIRNYS LGCNGSHFDV TSHLRMQPDP 750
    AQGHKGTSVI ITNGS 765
    Length:765
    Mass (Da):85,541
    Last modified:July 15, 1999 - v3
    Checksum:iB1A7F7DA8578CD17
    GO

    Sequence cautioni

    The sequence AAA91201.1 differs from that shown. Reason: Erroneous termination at position 697. Translated as Cys.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti133 – 1331H → L in AAA91201. (PubMed:8812055)Curated
    Sequence conflicti133 – 1331H → L in AAC05481. (PubMed:8812055)Curated
    Sequence conflicti176 – 1761Missing in AAA91201. (PubMed:8812055)Curated
    Sequence conflicti322 – 3221P → R in AAA91201. (PubMed:8812055)Curated
    Sequence conflicti322 – 3221P → R in AAC05481. (PubMed:8812055)Curated
    Sequence conflicti480 – 4801A → P in AAA91201. (PubMed:8812055)Curated
    Sequence conflicti537 – 5371D → S in AAA91201. (PubMed:8812055)Curated
    Sequence conflicti698 – 6981F → K in AAA91201. (PubMed:8812055)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U40575 mRNA. Translation: AAA91201.1. Sequence problems.
    AF038857
    , AF038853, AF038854, AF038856, AF044913, AF038855 Genomic DNA. Translation: AAC05481.1.
    D79209 mRNA. Translation: BAA11467.1.
    AB013491 Genomic DNA. Translation: BAA28270.1.
    CCDSiCCDS48556.1.
    RefSeqiNP_035506.2. NM_011376.3.
    XP_006512690.1. XM_006512627.1.
    UniGeneiMm.4774.

    Genome annotation databases

    EnsembliENSMUST00000020071; ENSMUSP00000020071; ENSMUSG00000019913.
    GeneIDi20464.
    KEGGimmu:20464.
    UCSCiuc007fal.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U40575 mRNA. Translation: AAA91201.1 . Sequence problems.
    AF038857
    , AF038853 , AF038854 , AF038856 , AF044913 , AF038855 Genomic DNA. Translation: AAC05481.1 .
    D79209 mRNA. Translation: BAA11467.1 .
    AB013491 Genomic DNA. Translation: BAA28270.1 .
    CCDSi CCDS48556.1.
    RefSeqi NP_035506.2. NM_011376.3.
    XP_006512690.1. XM_006512627.1.
    UniGenei Mm.4774.

    3D structure databases

    ProteinModelPortali Q61045.
    SMRi Q61045. Positions 2-333.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    IntActi Q61045. 3 interactions.

    PTM databases

    PhosphoSitei Q61045.

    Proteomic databases

    PRIDEi Q61045.

    Protocols and materials databases

    DNASUi 20464.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000020071 ; ENSMUSP00000020071 ; ENSMUSG00000019913 .
    GeneIDi 20464.
    KEGGi mmu:20464.
    UCSCi uc007fal.1. mouse.

    Organism-specific databases

    CTDi 6492.
    MGIi MGI:98306. Sim1.

    Phylogenomic databases

    eggNOGi NOG310284.
    GeneTreei ENSGT00730000110507.
    HOGENOMi HOG000236298.
    HOVERGENi HBG003936.
    InParanoidi Q61045.
    KOi K09100.
    OMAi GEVCHSS.
    OrthoDBi EOG790G0R.
    PhylomeDBi Q61045.
    TreeFami TF317772.

    Miscellaneous databases

    NextBioi 298559.
    PROi Q61045.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q61045.
    CleanExi MM_SIM1.
    Genevestigatori Q61045.

    Family and domain databases

    Gene3Di 4.10.280.10. 1 hit.
    InterProi IPR011598. bHLH_dom.
    IPR001610. PAC.
    IPR000014. PAS.
    IPR013767. PAS_fold.
    IPR013655. PAS_fold_3.
    IPR010578. SIM_C.
    [Graphical view ]
    Pfami PF00010. HLH. 1 hit.
    PF00989. PAS. 1 hit.
    PF08447. PAS_3. 1 hit.
    PF06621. SIM_C. 1 hit.
    [Graphical view ]
    SMARTi SM00353. HLH. 1 hit.
    SM00086. PAC. 1 hit.
    SM00091. PAS. 2 hits.
    [Graphical view ]
    SUPFAMi SSF47459. SSF47459. 1 hit.
    SSF55785. SSF55785. 2 hits.
    PROSITEi PS50888. BHLH. 1 hit.
    PS50112. PAS. 2 hits.
    PS51302. SIM_C. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Expression patterns of two murine homologs of Drosophila single-minded suggest possible roles in embryonic patterning and in the pathogenesis of Down syndrome."
      Fan C.-M., Kuwana E., Bulfone A., Fletcher C.F., Copeland N.G., Jenkins N.A., Crews S., Martinez S., Puelles L., Rubenstein J.L., Tessier-Lavigne M.
      Mol. Cell. Neurosci. 7:1-16(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA].
      Strain: 129/Sv and Swiss Webster.
      Tissue: Embryonic brain and Embryonic stem cell.
    2. "Cloning of two human homologs of the Drosophila single-minded gene SIM1 on chromosome 6q and SIM2 on 21q within the Down syndrome chromosomal region."
      Chrast R., Scott H.S., Chen H., Kudoh J., Rossier C., Minoshima S., Wang Y., Shimizu N., Antonarakis S.E.
      Genome Res. 7:615-624(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: SEQUENCE REVISION TO C-TERMINUS.
    3. "Two new members of the murine Sim gene family are transcriptional repressors and show different expression patterns during mouse embryogenesis."
      Ema M., Morita M., Ikawa S., Tanaka M., Matsuda Y., Gotoh O., Saijoh Y., Fujii H., Hamada H., Kikuchi Y., Fujii-Kuriyama Y.
      Mol. Cell. Biol. 16:5865-5875(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: C57BL/6J.
    4. "Mouse single-minded1 (mSim1) gene."
      Hosoya T.
      Submitted (APR-1998) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: 129/Sv.
    5. "Two murine homologs of the Drosophila single-minded protein that interact with the mouse aryl hydrocarbon receptor nuclear translocator protein."
      Probst M.R., Fan C.-M., Tessier-Lavigne M., Hankinson O.
      J. Biol. Chem. 272:4451-4457(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: SUBUNIT.

    Entry informationi

    Entry nameiSIM1_MOUSE
    AccessioniPrimary (citable) accession number: Q61045
    Secondary accession number(s): O70284, P70183
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1997
    Last sequence update: July 15, 1999
    Last modified: October 1, 2014
    This is version 130 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3