Single-minded homolog 1 - Mus musculus (Mouse)

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Q61045 (SIM1_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified May 1, 2013. Version 117. History...

Clusters with 100%, 90%, 50% identity |

Documents (2) |

Third-party data

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Names·Attributes·General annotation·Ontologies·Interactions·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents Customize order

Names and origin

Protein names

Recommended name:
Single-minded homolog 1
Short name=mSIM1

Gene names

Name:

Sim1

Organism

Mus musculus (Mouse) [Reference proteome]

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length	765 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Transcriptional factor that may have pleiotropic effects during embryogenesis and in the adult.
Subunit structure	Efficient DNA binding requires dimerization with another bHLH protein. Heterodimer of SIM1 and ARNT. Ref.6
Subcellular location	Nucleus By similarity.
Tissue specificity	Detected in lung, skeletal muscle and kidney. During fetal development it is found in the CNS, developing kidney, mesodermal and endodermal tissues, including developing somites, mesonephric duct, and foregut.
Sequence similarities	Contains 1 bHLH (basic helix-loop-helix) domain. Contains 1 PAC (PAS-associated C-terminal) domain. Contains 2 PAS (PER-ARNT-SIM) domains. Contains 1 Single-minded C-terminal domain.
Sequence caution	The sequence AAA91201.1 differs from that shown. Reason: Erroneous termination at position 697. Translated as Cys.

Ontologies

Keywords
Biological process	Differentiation Neurogenesis Transcription Transcription regulation
Cellular component	Nucleus
Domain	Repeat
Ligand	DNA-binding
Molecular function	Developmental protein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	cell differentiation Inferred from electronic annotation. Source: UniProtKB-KW nervous system development Inferred from electronic annotation. Source: UniProtKB-KW regulation of transcription, DNA-dependent Inferred from direct assay PubMed 11782478. Source: MGI transcription, DNA-dependent Inferred from electronic annotation. Source: UniProtKB-KW ureteric bud development Inferred from expression pattern PubMed 16545622. Source: UniProtKB
Cellular_component	nucleus Inferred from direct assay PubMed 11782478. Source: MGI
Molecular_function	DNA binding Inferred from electronic annotation. Source: UniProtKB-KW sequence-specific DNA binding transcription factor activity Inferred from electronic annotation. Source: InterPro signal transducer activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Binary interactions

With	Entry	#Exp.	IntAct	Notes
Arnt	P53762	2	EBI-78890,EBI-78852

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – 765

765

Single-minded homolog 1

PRO_0000127440

Regions

Domain

1 – 53

bHLH

Domain

77 – 147

PAS 1

Domain

218 – 288

PAS 2

Domain

292 – 335

PAC

Domain

336 – 765

430

Single-minded C-terminal

Motif

368 – 387

Nuclear localization signal By similarity

Experimental info

Sequence conflict

133

H → L in AAA91201. Ref.1

Sequence conflict

133

H → L in AAC05481. Ref.1

Sequence conflict

176

Missing in AAA91201. Ref.1

Sequence conflict

322

P → R in AAA91201. Ref.1

Sequence conflict

322

P → R in AAC05481. Ref.1

Sequence conflict

480

A → P in AAA91201. Ref.1

Sequence conflict

537

D → S in AAA91201. Ref.1

Sequence conflict

698

F → K in AAA91201. Ref.1

Sequences

Sequence

Length

Mass (Da)

Tools

Q61045 [UniParc].

Last modified July 15, 1999. Version 3.
Checksum: B1A7F7DA8578CD17
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FASTA

765

85,541

        10         20         30         40         50         60 
MKEKSKNAAR TRREKENSEF YELAKLLPLP SAITSQLDKA SIIRLTTSYL KMRVVFPEGL 

        70         80         90        100        110        120 
GEAWGHTSRT SPLDNVGREL GSHLLQTLDG FIFVVAPDGK IMYISETASV HLGLSQVELT 

       130        140        150        160        170        180 
GNSIYEYIHP ADHDEMTAVL TAHQPYHSHF VQEYEIERSF FLRMKCVLAK RNAGLTCGGY 

       190        200        210        220        230        240 
KVIHCSGYLK IRQYSLDMSP FDGCYQNVGL VAVGHSLPPS AVTEIKLHSN MFMFRASLDM 

       250        260        270        280        290        300 
KLIFLDSRVA ELTGYEPQDL IEKTLYHHVH GCDTFHLRCA HHLLLVKGQV TTKYYRFLAK 

       310        320        330        340        350        360 
QGGWVWVQSY ATIVHNSRSS RPHCIVSVNY VLTDTEYKGL QLSLDQISAS KPTFSYTSSS 

       370        380        390        400        410        420 
TPTISDNRKG AKSRLSSSKS KSRTSPYPQY SGFHTERSES DHDSQWGGSP LTDTASPQLL 

       430        440        450        460        470        480 
DPERPGSQHE LSCAYRQFPD RSSLCYGFAL DHSRLVEDRH FHTQACEGGR CEAGRYFLGA 

       490        500        510        520        530        540 
PPTGRDPWWG SRAALPLTKA SPESREAYEN SMPHITSIHR IHGRGHWDED SVVSSPDPGS 

       550        560        570        580        590        600 
ASESGDRYRT EQYQNSPHEP SKIETLIRAT QQMIKEEENR LQLRKAPPDQ LASINGAGKK 

       610        620        630        640        650        660 
HSLCFANYQQ PPPTGEVCHS SALASTSPCD HIQQREGKML SPHENDYDNS PTALSRISSP 

       670        680        690        700        710        720 
SSDRITKSSL ILAKDYLHSD MSPHQTAGDH PAISPNCFGS HRQYFDKHAY TLTGYALEHL 

       730        740        750        760 
YDSETIRNYS LGCNGSHFDV TSHLRMQPDP AQGHKGTSVI ITNGS

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References

[1]	"Expression patterns of two murine homologs of Drosophila single-minded suggest possible roles in embryonic patterning and in the pathogenesis of Down syndrome." Fan C.-M., Kuwana E., Bulfone A., Fletcher C.F., Copeland N.G., Jenkins N.A., Crews S., Martinez S., Puelles L., Rubenstein J.L., Tessier-Lavigne M. Mol. Cell. Neurosci. 7:1-16(1996) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA]. Strain: 129/Sv and Swiss Webster. Tissue: Embryonic brain and Embryonic stem cell.
[2]	Erratum Fan C.-M., Kuwana E., Bulfone A., Fletcher C.F., Copeland N.G., Jenkins N.A., Crews S., Martinez S., Puelles L., Rubenstein J.L., Tessier-Lavigne M. Mol. Cell. Neurosci. 7:519-519(1996) [PubMed] [Europe PMC] [Abstract]
[3]	"Cloning of two human homologs of the Drosophila single-minded gene SIM1 on chromosome 6q and SIM2 on 21q within the Down syndrome chromosomal region." Chrast R., Scott H.S., Chen H., Kudoh J., Rossier C., Minoshima S., Wang Y., Shimizu N., Antonarakis S.E. Genome Res. 7:615-624(1997) [PubMed] [Europe PMC] [Abstract] Cited for: SEQUENCE REVISION TO C-TERMINUS.
[4]	"Two new members of the murine Sim gene family are transcriptional repressors and show different expression patterns during mouse embryogenesis." Ema M., Morita M., Ikawa S., Tanaka M., Matsuda Y., Gotoh O., Saijoh Y., Fujii H., Hamada H., Kikuchi Y., Fujii-Kuriyama Y. Mol. Cell. Biol. 16:5865-5875(1996) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Strain: C57BL/6J.
[5]	"Mouse single-minded1 (mSim1) gene." Hosoya T. Submitted (APR-1998) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: 129/Sv.
[6]	"Two murine homologs of the Drosophila single-minded protein that interact with the mouse aryl hydrocarbon receptor nuclear translocator protein." Probst M.R., Fan C.-M., Tessier-Lavigne M., Hankinson O. J. Biol. Chem. 272:4451-4457(1997) [PubMed] [Europe PMC] [Abstract] Cited for: SUBUNIT.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	U40575 mRNA. Translation: AAA91201.1. Sequence problems. AF038857 AF038855 Genomic DNA. Translation: AAC05481.1. D79209 mRNA. Translation: BAA11467.1. AB013491 Genomic DNA. Translation: BAA28270.1.
IPI	IPI00117015.
RefSeq	NP_035506.2. NM_011376.3.
UniGene	Mm.4774.
3D structure databases
ProteinModelPortal	Q61045.
SMR	Q61045. Positions 2-333.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q61045. 2 interactions.
PTM databases
PhosphoSite	Q61045.
Proteomic databases
PRIDE	Q61045.
Protocols and materials databases
DNASU	20464.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSMUST00000020071; ENSMUSP00000020071; ENSMUSG00000019913.
GeneID	20464.
KEGG	mmu:20464.
UCSC	uc007fal.1. mouse.
Organism-specific databases
CTD	6492.
MGI	MGI:98306. Sim1.
Phylogenomic databases
eggNOG	NOG310284.
GeneTree	ENSGT00700000104038.
HOGENOM	HOG000236298.
HOVERGEN	HBG003936.
InParanoid	Q61045.
KO	K09100.
OMA	NSMPHIT.
OrthoDB	EOG4QC14V.
Gene expression databases
Bgee	Q61045.
CleanEx	MM_SIM1.
Genevestigator	Q61045.
GermOnline	ENSMUSG00000019913. Mus musculus.
Family and domain databases
Gene3D	4.10.280.10. 1 hit.
InterPro	IPR011598. bHLH_dom. IPR001610. PAC. IPR000014. PAS. IPR013767. PAS_fold. IPR013655. PAS_fold_3. IPR010578. SIM_C. [Graphical view]
Pfam	PF00010. HLH. 1 hit. PF00989. PAS. 1 hit. PF08447. PAS_3. 1 hit. PF06621. SIM_C. 1 hit. [Graphical view]
SMART	SM00353. HLH. 1 hit. SM00086. PAC. 1 hit. SM00091. PAS. 2 hits. [Graphical view]
SUPFAM	SSF47459. HLH_basic. 1 hit.
PROSITE	PS50888. BHLH. 1 hit. PS50113. PAC. False negative. PS50112. PAS. 2 hits. PS51302. SIM_C. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	298559.
SOURCE	Search...

Entry information

Entry name

SIM1_MOUSE

Accession

Primary (citable) accession number: Q61045
Secondary accession number(s): O70284, P70183

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1997
Last sequence update:	July 15, 1999
Last modified:	May 1, 2013
This is version 117 of the entry and version 3 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Relevant documents

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

SIMILARITY comments

Index of protein domains and families

Names·Attributes·General annotation·Ontologies·Interactions·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents

Preferred order of sections

Names and origin

Protein attributes

General annotation (Comments)

Ontologies

Binary interactions

With

Entry

#Exp.

IntAct

Notes

Sequence annotation (Features)

Molecule processing

Regions

Experimental info

Sequences

References

Cross-references

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Gene expression databases

Family and domain databases

Other

Entry information

Relevant documents