Sim1

Functionⁱ

Transcriptional factor that may have pleiotropic effects during embryogenesis and in the adult.

GO - Molecular functionⁱ

DNA binding Source: UniProtKB-KW
protein heterodimerization activity
Source: UniProtKB
Inferred from physical interactionⁱ
- 8927054
RNA polymerase II transcription factor activity, sequence-specific DNA binding Source: GO_Central

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

cell differentiation Source: UniProtKB-KW
nervous system development Source: GO_Central
regulation of transcription, DNA-templated
Source: MGI
Inferred from direct assayⁱ
- 11782478
regulation of transcription by RNA polymerase II Source: GO_Central
transcription, DNA-templated Source: UniProtKB-KW
ureteric bud development
Source: UniProtKB
Inferred from expression patternⁱ
- 16545622

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Developmental protein, DNA-binding
Biological process	Differentiation, Neurogenesis, Transcription, Transcription regulation

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Single-minded homolog 1 Short name: mSIM1
Gene namesⁱ	Name:Sim1
Organismⁱ	Mus musculus (Mouse)
Taxonomic identifierⁱ	10090 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus
Proteomesⁱ	UP000000589 Componentⁱ: Chromosome 10

Organism-specific databases

MGIⁱ	MGI:98306 Sim1

Keywords - Cellular componentⁱ

Nucleus

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000127440	1 – 765	Single-minded homolog 1Add BLAST		765

Proteomic databases

PaxDbⁱ	Q61045
PRIDEⁱ	Q61045

PTM databases

iPTMnetⁱ	Q61045
PhosphoSitePlusⁱ	Q61045

Expressionⁱ

Tissue specificityⁱ

Detected in lung, skeletal muscle and kidney. During fetal development it is found in the CNS, developing kidney, mesodermal and endodermal tissues, including developing somites, mesonephric duct, and foregut.

Gene expression databases

Bgeeⁱ	ENSMUSG00000019913
CleanExⁱ	MM_SIM1
ExpressionAtlasⁱ	Q61045 baseline and differential
Genevisibleⁱ	Q61045 MM

Interactionⁱ

Subunit structureⁱ

Efficient DNA binding requires dimerization with another bHLH protein. Heterodimer of SIM1 and ARNT.1 Publication

Binary interactionsⁱ

With	Entry	#Exp.	IntAct	Notes
Arnt	P53762	2	EBI-78890,EBI-78852

With

Entry

#Exp.

IntAct

Notes

Arnt

P53762

2

EBI-78890,EBI-78852

GO - Molecular functionⁱ

protein heterodimerization activity
Source: UniProtKB
Inferred from physical interactionⁱ
- 8927054

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

CORUMⁱ	Q61045
IntActⁱ	Q61045 3 interactors.
Molecular INTeraction database More...MINTⁱ	Q61045
STRINGⁱ	10090.ENSMUSP00000020071

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q61045
SMRⁱ	Q61045
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Length
Domainⁱ	1 – 53	bHLHPROSITE-ProRule annotationAdd BLAST	53
Domainⁱ	77 – 147	PAS 1PROSITE-ProRule annotationAdd BLAST	71
Domainⁱ	218 – 288	PAS 2PROSITE-ProRule annotationAdd BLAST	71
Domainⁱ	292 – 335	PACAdd BLAST	44
Domainⁱ	336 – 765	Single-minded C-terminalPROSITE-ProRule annotationAdd BLAST	430

Motif

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Motifⁱ	368 – 387	Nuclear localization signalBy similarityAdd BLAST		20

Keywords - Domainⁱ

Repeat

Phylogenomic databases

eggNOGⁱ	KOG3559 Eukaryota ENOG410XY57 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00760000118788
HOGENOMⁱ	HOG000236298
HOVERGENⁱ	HBG003936
InParanoidⁱ	Q61045
KEGG Orthology (KO) More...KOⁱ	K09100
OMAⁱ	ISPNCFG
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G06FQ
PhylomeDBⁱ	Q61045
TreeFamⁱ	TF317772

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd00083 HLH, 1 hit cd00130 PAS, 2 hits
Gene3Dⁱ	4.10.280.101 hit
InterProⁱ	View protein in InterPro IPR011598 bHLH_dom IPR036638 HLH_DNA-bd_sf IPR001610 PAC IPR000014 PAS IPR035965 PAS-like_dom_sf IPR013767 PAS_fold IPR013655 PAS_fold_3 IPR010578 SIM_C
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00010 HLH, 1 hit PF00989 PAS, 1 hit PF08447 PAS_3, 1 hit PF06621 SIM_C, 1 hit
SMARTⁱ	View protein in SMART SM00353 HLH, 1 hit SM00086 PAC, 1 hit SM00091 PAS, 2 hits
SUPFAMⁱ	SSF47459 SSF47459, 1 hit SSF55785 SSF55785, 2 hits
PROSITEⁱ	View protein in PROSITE PS50888 BHLH, 1 hit PS50112 PAS, 2 hits PS51302 SIM_C, 1 hit

Sequenceⁱ

Sequence statusⁱ: Complete.

Q61045-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MKEKSKNAAR TRREKENSEF YELAKLLPLP SAITSQLDKA SIIRLTTSYL 
        60         70         80         90        100
KMRVVFPEGL GEAWGHTSRT SPLDNVGREL GSHLLQTLDG FIFVVAPDGK 
       110        120        130        140        150
IMYISETASV HLGLSQVELT GNSIYEYIHP ADHDEMTAVL TAHQPYHSHF 
       160        170        180        190        200
VQEYEIERSF FLRMKCVLAK RNAGLTCGGY KVIHCSGYLK IRQYSLDMSP 
       210        220        230        240        250
FDGCYQNVGL VAVGHSLPPS AVTEIKLHSN MFMFRASLDM KLIFLDSRVA 
       260        270        280        290        300
ELTGYEPQDL IEKTLYHHVH GCDTFHLRCA HHLLLVKGQV TTKYYRFLAK 
       310        320        330        340        350
QGGWVWVQSY ATIVHNSRSS RPHCIVSVNY VLTDTEYKGL QLSLDQISAS 
       360        370        380        390        400
KPTFSYTSSS TPTISDNRKG AKSRLSSSKS KSRTSPYPQY SGFHTERSES 
       410        420        430        440        450
DHDSQWGGSP LTDTASPQLL DPERPGSQHE LSCAYRQFPD RSSLCYGFAL 
       460        470        480        490        500
DHSRLVEDRH FHTQACEGGR CEAGRYFLGA PPTGRDPWWG SRAALPLTKA 
       510        520        530        540        550
SPESREAYEN SMPHITSIHR IHGRGHWDED SVVSSPDPGS ASESGDRYRT 
       560        570        580        590        600
EQYQNSPHEP SKIETLIRAT QQMIKEEENR LQLRKAPPDQ LASINGAGKK 
       610        620        630        640        650
HSLCFANYQQ PPPTGEVCHS SALASTSPCD HIQQREGKML SPHENDYDNS 
       660        670        680        690        700
PTALSRISSP SSDRITKSSL ILAKDYLHSD MSPHQTAGDH PAISPNCFGS 
       710        720        730        740        750
HRQYFDKHAY TLTGYALEHL YDSETIRNYS LGCNGSHFDV TSHLRMQPDP 
       760 
AQGHKGTSVI ITNGS

Length:765

Mass (Da):85,541

Last modified:July 15, 1999 - v3

Checksum:ⁱB1A7F7DA8578CD17

GO

Sequence cautionⁱ

The sequence AAA91201 differs from that shown. Reason: Erroneous termination at position 697. Translated as Cys.Curated

Experimental Info

Feature key	Position(s)	DescriptionActions	Length
Sequence conflictⁱ	133	H → L in AAA91201 (PubMed:8812055).Curated	1
Sequence conflictⁱ	133	H → L in AAC05481 (PubMed:8812055).Curated	1
Sequence conflictⁱ	176	Missing in AAA91201 (PubMed:8812055).Curated	1
Sequence conflictⁱ	322	P → R in AAA91201 (PubMed:8812055).Curated	1
Sequence conflictⁱ	322	P → R in AAC05481 (PubMed:8812055).Curated	1
Sequence conflictⁱ	480	A → P in AAA91201 (PubMed:8812055).Curated	1
Sequence conflictⁱ	537	D → S in AAA91201 (PubMed:8812055).Curated	1
Sequence conflictⁱ	698	F → K in AAA91201 (PubMed:8812055).Curated	1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	U40575 mRNA Translation: AAA91201.1 Sequence problems. AF038857 AF038855 Genomic DNA Translation: AAC05481.1 D79209 mRNA Translation: BAA11467.1 AB013491 Genomic DNA Translation: BAA28270.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS48556.1
NCBI Reference Sequences More...RefSeqⁱ	NP_035506.2, NM_011376.3 XP_006512690.1, XM_006512627.3
UniGeneⁱ	Mm.4774

Genome annotation databases

Ensemblⁱ	ENSMUST00000020071; ENSMUSP00000020071; ENSMUSG00000019913
GeneIDⁱ	20464
KEGGⁱ	mmu:20464
UCSC genome browser More...UCSCⁱ	uc007fal.1 mouse

Similar proteinsⁱ

90% Identity
50% Identity

Protein	Similar proteins	Organisms	Length	Cluster ID	Cluster name	Size
Q61045	P81133 G3RLN9 UPI0003D75575 UPI0003D6FE2C UPI0003D779EE UPI0003D72FF0 UPI0009453371 A0A2K6Q4Z3 A0A2K6K3F8 UPI00083C8B6D +61	Homo sapiens (Human) Gorilla gorilla gorilla (Western lowland gorilla) Mus musculus (Mouse) Rhinolophus sinicus (Chinese rufous horseshoe bat) Rhinopithecus roxellana (Golden snub-nosed monkey) (Pygathrix roxellana) Rhinopithecus bieti (Black snub-nosed monkey) (Pygathrix bieti) Papio anubis (Olive baboon) Cercocebus atys (Sooty mangabey) (Cercocebus torquatus atys) Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) Canis lupus familiaris (Dog) (Canis familiaris) And more	766	UniRef90_P81133	Cluster: Single-minded homolog 1	72

Protein	Similar proteins	Organisms	Length	Cluster ID	Cluster name	Size
Q61045	P81133 G3RLN9 UPI0003D75575 UPI0003D6FE2C UPI0003D779EE UPI0003D72FF0 UPI0009453371 G1RUD0 A0A2J8SK85 H2PJW3 +230	Homo sapiens (Human) Gorilla gorilla gorilla (Western lowland gorilla) Mus musculus (Mouse) Rhinolophus sinicus (Chinese rufous horseshoe bat) Nomascus leucogenys (Northern white-cheeked gibbon) (Hylobates leucogenys) Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) Cebus capucinus imitator Pan paniscus (Pygmy chimpanzee) (Bonobo) Pteropus vampyrus (Large flying fox) Enhydra lutris kenyoni And more	766	UniRef50_P81133	Cluster: Single-minded homolog 1	241

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	U40575 mRNA Translation: AAA91201.1 Sequence problems. AF038857 AF038855 Genomic DNA Translation: AAC05481.1 D79209 mRNA Translation: BAA11467.1 AB013491 Genomic DNA Translation: BAA28270.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS48556.1
NCBI Reference Sequences More...RefSeqⁱ	NP_035506.2, NM_011376.3 XP_006512690.1, XM_006512627.3
UniGeneⁱ	Mm.4774

3D structure databases

ProteinModelPortalⁱ	Q61045
SMRⁱ	Q61045
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

CORUMⁱ	Q61045
IntActⁱ	Q61045 3 interactors.
Molecular INTeraction database More...MINTⁱ	Q61045
STRINGⁱ	10090.ENSMUSP00000020071

PTM databases

iPTMnetⁱ	Q61045
PhosphoSitePlusⁱ	Q61045

Proteomic databases

PaxDbⁱ	Q61045
PRIDEⁱ	Q61045

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	20464
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENSMUST00000020071; ENSMUSP00000020071; ENSMUSG00000019913
GeneIDⁱ	20464
KEGGⁱ	mmu:20464
UCSC genome browser More...UCSCⁱ	uc007fal.1 mouse

Organism-specific databases

CTDⁱ	6492
MGIⁱ	MGI:98306 Sim1

Phylogenomic databases

eggNOGⁱ	KOG3559 Eukaryota ENOG410XY57 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00760000118788
HOGENOMⁱ	HOG000236298
HOVERGENⁱ	HBG003936
InParanoidⁱ	Q61045
KEGG Orthology (KO) More...KOⁱ	K09100
OMAⁱ	ISPNCFG
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G06FQ
PhylomeDBⁱ	Q61045
TreeFamⁱ	TF317772

Miscellaneous databases

Protein Ontology More...PROⁱ	PR:Q61045
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSMUSG00000019913
CleanExⁱ	MM_SIM1
ExpressionAtlasⁱ	Q61045 baseline and differential
Genevisibleⁱ	Q61045 MM

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd00083 HLH, 1 hit cd00130 PAS, 2 hits
Gene3Dⁱ	4.10.280.101 hit
InterProⁱ	View protein in InterPro IPR011598 bHLH_dom IPR036638 HLH_DNA-bd_sf IPR001610 PAC IPR000014 PAS IPR035965 PAS-like_dom_sf IPR013767 PAS_fold IPR013655 PAS_fold_3 IPR010578 SIM_C
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00010 HLH, 1 hit PF00989 PAS, 1 hit PF08447 PAS_3, 1 hit PF06621 SIM_C, 1 hit
SMARTⁱ	View protein in SMART SM00353 HLH, 1 hit SM00086 PAC, 1 hit SM00091 PAS, 2 hits
SUPFAMⁱ	SSF47459 SSF47459, 1 hit SSF55785 SSF55785, 2 hits
PROSITEⁱ	View protein in PROSITE PS50888 BHLH, 1 hit PS50112 PAS, 2 hits PS51302 SIM_C, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	SIM1_MOUSE
Accessionⁱ	Q61045Primary (citable) accession number: Q61045 Secondary accession number(s): O70284, P70183
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	November 1, 1997
	Last sequence update:	July 15, 1999
	Last modified:	March 28, 2018
	This is version 155 of the entry and version 3 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - Q61045 (SIM1_MOUSE)

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Single-minded homolog 1

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Nucleus

Nucleus

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Motif

Phylogenomic databases

Family and domain databases

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

Experimental Info

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

PTM / Processingⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence cautionⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ