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Q61045 (SIM1_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 129. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Interactions·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Single-minded homolog 1

Short name=mSIM1
Gene names
Name:Sim1
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length765 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Transcriptional factor that may have pleiotropic effects during embryogenesis and in the adult.

Subunit structure

Efficient DNA binding requires dimerization with another bHLH protein. Heterodimer of SIM1 and ARNT. Ref.6

Subcellular location

Nucleus By similarity.

Tissue specificity

Detected in lung, skeletal muscle and kidney. During fetal development it is found in the CNS, developing kidney, mesodermal and endodermal tissues, including developing somites, mesonephric duct, and foregut.

Sequence similarities

Contains 1 bHLH (basic helix-loop-helix) domain.

Contains 1 PAC (PAS-associated C-terminal) domain.

Contains 2 PAS (PER-ARNT-SIM) domains.

Contains 1 Single-minded C-terminal domain.

Sequence caution

The sequence AAA91201.1 differs from that shown. Reason: Erroneous termination at position 697. Translated as Cys.

Binary interactions

With

Entry

#Exp.

IntAct

Notes

ArntP537622EBI-78890,EBI-78852

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 765765Single-minded homolog 1
PRO_0000127440

Regions

Domain1 – 5353bHLH
Domain77 – 14771PAS 1
Domain218 – 28871PAS 2
Domain292 – 33544PAC
Domain336 – 765430Single-minded C-terminal
Motif368 – 38720Nuclear localization signal By similarity

Experimental info

Sequence conflict1331H → L in AAA91201. Ref.1
Sequence conflict1331H → L in AAC05481. Ref.1
Sequence conflict1761Missing in AAA91201. Ref.1
Sequence conflict3221P → R in AAA91201. Ref.1
Sequence conflict3221P → R in AAC05481. Ref.1
Sequence conflict4801A → P in AAA91201. Ref.1
Sequence conflict5371D → S in AAA91201. Ref.1
Sequence conflict6981F → K in AAA91201. Ref.1

Sequences

Sequence LengthMass (Da)Tools
Q61045 [UniParc].

Last modified July 15, 1999. Version 3.
Checksum: B1A7F7DA8578CD17

FASTA76585,541
        10         20         30         40         50         60 
MKEKSKNAAR TRREKENSEF YELAKLLPLP SAITSQLDKA SIIRLTTSYL KMRVVFPEGL 

        70         80         90        100        110        120 
GEAWGHTSRT SPLDNVGREL GSHLLQTLDG FIFVVAPDGK IMYISETASV HLGLSQVELT 

       130        140        150        160        170        180 
GNSIYEYIHP ADHDEMTAVL TAHQPYHSHF VQEYEIERSF FLRMKCVLAK RNAGLTCGGY 

       190        200        210        220        230        240 
KVIHCSGYLK IRQYSLDMSP FDGCYQNVGL VAVGHSLPPS AVTEIKLHSN MFMFRASLDM 

       250        260        270        280        290        300 
KLIFLDSRVA ELTGYEPQDL IEKTLYHHVH GCDTFHLRCA HHLLLVKGQV TTKYYRFLAK 

       310        320        330        340        350        360 
QGGWVWVQSY ATIVHNSRSS RPHCIVSVNY VLTDTEYKGL QLSLDQISAS KPTFSYTSSS 

       370        380        390        400        410        420 
TPTISDNRKG AKSRLSSSKS KSRTSPYPQY SGFHTERSES DHDSQWGGSP LTDTASPQLL 

       430        440        450        460        470        480 
DPERPGSQHE LSCAYRQFPD RSSLCYGFAL DHSRLVEDRH FHTQACEGGR CEAGRYFLGA 

       490        500        510        520        530        540 
PPTGRDPWWG SRAALPLTKA SPESREAYEN SMPHITSIHR IHGRGHWDED SVVSSPDPGS 

       550        560        570        580        590        600 
ASESGDRYRT EQYQNSPHEP SKIETLIRAT QQMIKEEENR LQLRKAPPDQ LASINGAGKK 

       610        620        630        640        650        660 
HSLCFANYQQ PPPTGEVCHS SALASTSPCD HIQQREGKML SPHENDYDNS PTALSRISSP 

       670        680        690        700        710        720 
SSDRITKSSL ILAKDYLHSD MSPHQTAGDH PAISPNCFGS HRQYFDKHAY TLTGYALEHL 

       730        740        750        760 
YDSETIRNYS LGCNGSHFDV TSHLRMQPDP AQGHKGTSVI ITNGS 

« Hide

References

[1]"Expression patterns of two murine homologs of Drosophila single-minded suggest possible roles in embryonic patterning and in the pathogenesis of Down syndrome."
Fan C.-M., Kuwana E., Bulfone A., Fletcher C.F., Copeland N.G., Jenkins N.A., Crews S., Martinez S., Puelles L., Rubenstein J.L., Tessier-Lavigne M.
Mol. Cell. Neurosci. 7:1-16(1996) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA].
Strain: 129/Sv and Swiss Webster.
Tissue: Embryonic brain and Embryonic stem cell.
[2]Erratum
Fan C.-M., Kuwana E., Bulfone A., Fletcher C.F., Copeland N.G., Jenkins N.A., Crews S., Martinez S., Puelles L., Rubenstein J.L., Tessier-Lavigne M.
Mol. Cell. Neurosci. 7:519-519(1996) [PubMed] [Europe PMC] [Abstract]
[3]"Cloning of two human homologs of the Drosophila single-minded gene SIM1 on chromosome 6q and SIM2 on 21q within the Down syndrome chromosomal region."
Chrast R., Scott H.S., Chen H., Kudoh J., Rossier C., Minoshima S., Wang Y., Shimizu N., Antonarakis S.E.
Genome Res. 7:615-624(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: SEQUENCE REVISION TO C-TERMINUS.
[4]"Two new members of the murine Sim gene family are transcriptional repressors and show different expression patterns during mouse embryogenesis."
Ema M., Morita M., Ikawa S., Tanaka M., Matsuda Y., Gotoh O., Saijoh Y., Fujii H., Hamada H., Kikuchi Y., Fujii-Kuriyama Y.
Mol. Cell. Biol. 16:5865-5875(1996) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Strain: C57BL/6J.
[5]"Mouse single-minded1 (mSim1) gene."
Hosoya T.
Submitted (APR-1998) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: 129/Sv.
[6]"Two murine homologs of the Drosophila single-minded protein that interact with the mouse aryl hydrocarbon receptor nuclear translocator protein."
Probst M.R., Fan C.-M., Tessier-Lavigne M., Hankinson O.
J. Biol. Chem. 272:4451-4457(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: SUBUNIT.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
U40575 mRNA. Translation: AAA91201.1. Sequence problems.
AF038857 expand/collapse EMBL AC list , AF038853, AF038854, AF038856, AF044913, AF038855 Genomic DNA. Translation: AAC05481.1.
D79209 mRNA. Translation: BAA11467.1.
AB013491 Genomic DNA. Translation: BAA28270.1.
CCDSCCDS48556.1.
RefSeqNP_035506.2. NM_011376.3.
XP_006512690.1. XM_006512627.1.
UniGeneMm.4774.

3D structure databases

ProteinModelPortalQ61045.
SMRQ61045. Positions 2-333.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

IntActQ61045. 3 interactions.

PTM databases

PhosphoSiteQ61045.

Proteomic databases

PRIDEQ61045.

Protocols and materials databases

DNASU20464.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000020071; ENSMUSP00000020071; ENSMUSG00000019913.
GeneID20464.
KEGGmmu:20464.
UCSCuc007fal.1. mouse.

Organism-specific databases

CTD6492.
MGIMGI:98306. Sim1.

Phylogenomic databases

eggNOGNOG310284.
GeneTreeENSGT00730000110507.
HOGENOMHOG000236298.
HOVERGENHBG003936.
InParanoidQ61045.
KOK09100.
OMAGEVCHSS.
OrthoDBEOG790G0R.
PhylomeDBQ61045.
TreeFamTF317772.

Gene expression databases

BgeeQ61045.
CleanExMM_SIM1.
GenevestigatorQ61045.

Family and domain databases

Gene3D4.10.280.10. 1 hit.
InterProIPR011598. bHLH_dom.
IPR001610. PAC.
IPR000014. PAS.
IPR013767. PAS_fold.
IPR013655. PAS_fold_3.
IPR010578. SIM_C.
[Graphical view]
PfamPF00010. HLH. 1 hit.
PF00989. PAS. 1 hit.
PF08447. PAS_3. 1 hit.
PF06621. SIM_C. 1 hit.
[Graphical view]
SMARTSM00353. HLH. 1 hit.
SM00086. PAC. 1 hit.
SM00091. PAS. 2 hits.
[Graphical view]
SUPFAMSSF47459. SSF47459. 1 hit.
SSF55785. SSF55785. 2 hits.
PROSITEPS50888. BHLH. 1 hit.
PS50112. PAS. 2 hits.
PS51302. SIM_C. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio298559.
PROQ61045.
SOURCESearch...

Entry information

Entry nameSIM1_MOUSE
AccessionPrimary (citable) accession number: Q61045
Secondary accession number(s): O70284, P70183
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: July 15, 1999
Last modified: July 9, 2014
This is version 129 of the entry and version 3 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot