ID   NPY4R_MOUSE             Reviewed;         375 AA.
AC   Q61041; Q3UN46;
DT   01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT   27-JUL-2011, sequence version 2.
DT   24-JAN-2024, entry version 160.
DE   RecName: Full=Neuropeptide Y receptor type 4;
DE            Short=NPY4-R;
DE   AltName: Full=NPYR-D;
DE   AltName: Full=Pancreatic polypeptide receptor 1;
DE            Short=PP1;
GN   Name=Npy4r; Synonyms=Ppyr1;
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Mus; Mus.
OX   NCBI_TaxID=10090;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA], FUNCTION, SUBCELLULAR LOCATION, AND
RP   TISSUE SPECIFICITY.
RC   STRAIN=129/Sv;
RX   PubMed=8641440; DOI=10.1016/0014-5793(96)00067-1;
RA   Gregor P., Millham M.L., Feng Y., Decarr L.B., McCaleb M.L.,
RA   Cornfield L.J.;
RT   "Cloning and characterization of a novel receptor to pancreatic
RT   polypeptide, a member of the neuropeptide Y receptor family.";
RL   FEBS Lett. 381:58-62(1996).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=C57BL/6J; TISSUE=Gall bladder;
RX   PubMed=16141072; DOI=10.1126/science.1112014;
RA   Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA   Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA   Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA   Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA   Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA   Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA   Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA   Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA   Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA   Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA   Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA   Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA   Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA   Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA   Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA   Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA   Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA   Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA   Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA   Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA   Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA   Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA   Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA   Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA   Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA   van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA   Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA   Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA   Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA   Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA   Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA   Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA   Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA   Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT   "The transcriptional landscape of the mammalian genome.";
RL   Science 309:1559-1563(2005).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Brain;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
CC   -!- FUNCTION: G protein-coupled receptor for PPY/pancreatic polypeptide/PP
CC       that is negatively coupled to cAMP (PubMed:8641440). Has much lower
CC       affinity for the NPY/neuropeptide Y and PYY/peptide YY
CC       (PubMed:8641440). {ECO:0000269|PubMed:8641440}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:8641440};
CC       Multi-pass membrane protein {ECO:0000255}.
CC   -!- TISSUE SPECIFICITY: Heart, detected in small intestine.
CC       {ECO:0000269|PubMed:8641440}.
CC   -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC       {ECO:0000255|PROSITE-ProRule:PRU00521}.
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DR   EMBL; U40189; AAC52442.1; -; Genomic_DNA.
DR   EMBL; AK144461; BAE25901.1; -; mRNA.
DR   EMBL; BC132395; AAI32396.1; -; mRNA.
DR   EMBL; BC145981; AAI45982.1; -; mRNA.
DR   CCDS; CCDS26933.1; -.
DR   PIR; S63685; S63685.
DR   RefSeq; NP_032945.3; NM_008919.4.
DR   AlphaFoldDB; Q61041; -.
DR   SMR; Q61041; -.
DR   STRING; 10090.ENSMUSP00000056576; -.
DR   BindingDB; Q61041; -.
DR   ChEMBL; CHEMBL4105736; -.
DR   GuidetoPHARMACOLOGY; 307; -.
DR   GlyCosmos; Q61041; 4 sites, No reported glycans.
DR   GlyGen; Q61041; 4 sites.
DR   PhosphoSitePlus; Q61041; -.
DR   PaxDb; 10090-ENSMUSP00000056576; -.
DR   ProteomicsDB; 293885; -.
DR   DNASU; 19065; -.
DR   Ensembl; ENSMUST00000052164.4; ENSMUSP00000056576.4; ENSMUSG00000048337.4.
DR   GeneID; 19065; -.
DR   KEGG; mmu:19065; -.
DR   UCSC; uc007tak.2; mouse.
DR   AGR; MGI:105374; -.
DR   CTD; 5540; -.
DR   MGI; MGI:105374; Npy4r.
DR   VEuPathDB; HostDB:ENSMUSG00000048337; -.
DR   eggNOG; KOG3656; Eukaryota.
DR   GeneTree; ENSGT00940000161927; -.
DR   HOGENOM; CLU_009579_6_1_1; -.
DR   InParanoid; Q61041; -.
DR   OMA; FTVVYTM; -.
DR   OrthoDB; 2995026at2759; -.
DR   PhylomeDB; Q61041; -.
DR   TreeFam; TF315303; -.
DR   Reactome; R-MMU-375276; Peptide ligand-binding receptors.
DR   Reactome; R-MMU-418594; G alpha (i) signalling events.
DR   BioGRID-ORCS; 19065; 3 hits in 76 CRISPR screens.
DR   PRO; PR:Q61041; -.
DR   Proteomes; UP000000589; Chromosome 14.
DR   RNAct; Q61041; Protein.
DR   Bgee; ENSMUSG00000048337; Expressed in mesodermal cell in embryo and 12 other cell types or tissues.
DR   GO; GO:0043005; C:neuron projection; IBA:GO_Central.
DR   GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR   GO; GO:0042923; F:neuropeptide binding; IBA:GO_Central.
DR   GO; GO:0001602; F:pancreatic polypeptide receptor activity; IDA:MGI.
DR   GO; GO:0042277; F:peptide binding; ISO:MGI.
DR   GO; GO:0001601; F:peptide YY receptor activity; IDA:MGI.
DR   GO; GO:0007186; P:G protein-coupled receptor signaling pathway; IBA:GO_Central.
DR   CDD; cd15397; 7tmA_NPY4R; 1.
DR   Gene3D; 1.20.1070.10; Rhodopsin 7-helix transmembrane proteins; 1.
DR   InterPro; IPR000276; GPCR_Rhodpsn.
DR   InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR   InterPro; IPR001933; NPY4_rcpt.
DR   InterPro; IPR000611; NPY_rcpt.
DR   PANTHER; PTHR24235; NEUROPEPTIDE Y RECEPTOR; 1.
DR   PANTHER; PTHR24235:SF25; NEUROPEPTIDE Y RECEPTOR TYPE 4-RELATED; 1.
DR   Pfam; PF00001; 7tm_1; 1.
DR   PRINTS; PR00237; GPCRRHODOPSN.
DR   PRINTS; PR01015; NRPEPTIDEY4R.
DR   PRINTS; PR01012; NRPEPTIDEYR.
DR   SUPFAM; SSF81321; Family A G protein-coupled receptor-like; 1.
DR   PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
DR   PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
DR   Genevisible; Q61041; MM.
PE   2: Evidence at transcript level;
KW   Cell membrane; Disulfide bond; G-protein coupled receptor; Glycoprotein;
KW   Lipoprotein; Membrane; Palmitate; Receptor; Reference proteome; Transducer;
KW   Transmembrane; Transmembrane helix.
FT   CHAIN           1..375
FT                   /note="Neuropeptide Y receptor type 4"
FT                   /id="PRO_0000069936"
FT   TOPO_DOM        1..39
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        40..60
FT                   /note="Helical; Name=1"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        61..78
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        79..99
FT                   /note="Helical; Name=2"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        100..116
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        117..137
FT                   /note="Helical; Name=3"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        138..155
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        156..176
FT                   /note="Helical; Name=4"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        177..211
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        212..232
FT                   /note="Helical; Name=5"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        233..266
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        267..287
FT                   /note="Helical; Name=6"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        288..301
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        302..322
FT                   /note="Helical; Name=7"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        323..375
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   LIPID           340
FT                   /note="S-palmitoyl cysteine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        2
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        19
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        29
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        187
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   DISULFID        114..201
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00521"
FT   CONFLICT        166
FT                   /note="V -> I (in Ref. 1; AAC52442)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        346
FT                   /note="R -> Q (in Ref. 1; AAC52442)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   375 AA;  42648 MW;  6E04552C0E7F656E CRC64;
     MNTSHFLAPL FPGSLQGKNG TNPLDSPYNF SDGCQDSAEL LAFIITTYSI ETILGVLGNL
     CLIFVTTRQK EKSNVTNLLI ANLAFSDFLM CLICQPLTVT YTIMDYWIFG EVLCKMLTFI
     QCMSVTVSIL SLVLVALERH QLIINPTGWK PSIFQAYLGI VVIWFVSCFL SLPFLANSTL
     NDLFHYNHSK VVEFLEDKVV CFVSWSSDHH RLIYTTFLLL FQYCIPLAFI LVCYIRIYQR
     LQRQKHVFHA HACSSRAGQM KRINSMLMTM VTAFAVLWLP LHVFNTLEDW YQEAIPACHG
     NLIFLMCHLL AMASTCVNPF IYGFLNINFK KDIKALVLTC HCRSPRGESE HLPLSTVHTD
     LSKGSMRMGS KSNFI
//