Q61041 (NPY4R_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Neuropeptide Y receptor type 4
Short name=NPY4-R

Alternative name(s):
NPYR-D
Pancreatic polypeptide receptor 1
Short name=PP1

Gene names

Name:	Ppyr1
Synonyms:	Npy4r

Organism

Mus musculus (Mouse) [Reference proteome]

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length	375 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Receptor for neuropeptide Y and peptide YY. The rank order of affinity of this receptor for pancreatic polypeptides is PP >> PYY >= NPY.
Subcellular location	Cell membrane; Multi-pass membrane protein.
Tissue specificity	Heart, detected in small intestine.
Sequence similarities	Belongs to the G-protein coupled receptor 1 family.

Ontologies

Keywords
Cellular component	Cell membrane Membrane
Domain	Transmembrane Transmembrane helix
Molecular function	G-protein coupled receptor Receptor Transducer
PTM	Disulfide bond Glycoprotein Lipoprotein Palmitate
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Cellular_component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW plasma membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	pancreatic polypeptide receptor activity Inferred from direct assay PubMed 10698177Ref.1. Source: MGI peptide YY receptor activity Inferred from direct assay PubMed 10698177. Source: MGI peptide binding Inferred from electronic annotation. Source: Compara
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 375	375	Neuropeptide Y receptor type 4		PRO_0000069936
Regions
	Topological domain	1 – 39	39	Extracellular Potential
	Transmembrane	40 – 60	21	Helical; Name=1; Potential
	Topological domain	61 – 78	18	Cytoplasmic Potential
	Transmembrane	79 – 99	21	Helical; Name=2; Potential
	Topological domain	100 – 116	17	Extracellular Potential
	Transmembrane	117 – 137	21	Helical; Name=3; Potential
	Topological domain	138 – 155	18	Cytoplasmic Potential
	Transmembrane	156 – 176	21	Helical; Name=4; Potential
	Topological domain	177 – 211	35	Extracellular Potential
	Transmembrane	212 – 232	21	Helical; Name=5; Potential
	Topological domain	233 – 266	34	Cytoplasmic Potential
	Transmembrane	267 – 287	21	Helical; Name=6; Potential
	Topological domain	288 – 301	14	Extracellular Potential
	Transmembrane	302 – 322	21	Helical; Name=7; Potential
	Topological domain	323 – 375	53	Cytoplasmic Potential
Amino acid modifications
	Lipidation	340	1	S-palmitoyl cysteine Potential
	Glycosylation	2	1	N-linked (GlcNAc...) Potential
	Glycosylation	19	1	N-linked (GlcNAc...) Potential
	Glycosylation	29	1	N-linked (GlcNAc...) Potential
	Glycosylation	187	1	N-linked (GlcNAc...) Potential
	Disulfide bond	114 ↔ 201		By similarity
Experimental info
	Sequence conflict	166	1	V → I in AAC52442. Ref.1
	Sequence conflict	346	1	R → Q in AAC52442. Ref.1

Sequences

	Sequence		Length	Mass (Da)
	Q61041 [UniParc]. Last modified July 27, 2011. Version 2. Checksum: 6E04552C0E7F656E	FASTA	375	42,648
	10 20 30 40 50 60 MNTSHFLAPL FPGSLQGKNG TNPLDSPYNF SDGCQDSAEL LAFIITTYSI ETILGVLGNL 70 80 90 100 110 120 CLIFVTTRQK EKSNVTNLLI ANLAFSDFLM CLICQPLTVT YTIMDYWIFG EVLCKMLTFI 130 140 150 160 170 180 QCMSVTVSIL SLVLVALERH QLIINPTGWK PSIFQAYLGI VVIWFVSCFL SLPFLANSTL 190 200 210 220 230 240 NDLFHYNHSK VVEFLEDKVV CFVSWSSDHH RLIYTTFLLL FQYCIPLAFI LVCYIRIYQR 250 260 270 280 290 300 LQRQKHVFHA HACSSRAGQM KRINSMLMTM VTAFAVLWLP LHVFNTLEDW YQEAIPACHG 310 320 330 340 350 360 NLIFLMCHLL AMASTCVNPF IYGFLNINFK KDIKALVLTC HCRSPRGESE HLPLSTVHTD 370 LSKGSMRMGS KSNFI

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Cloning and characterization of a novel receptor to pancreatic polypeptide, a member of the neuropeptide Y receptor family." Gregor P., Millham M.L., Feng Y., Decarr L.B., McCaleb M.L., Cornfield L.J. FEBS Lett. 381:58-62(1996) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: 129/Sv.
[2]	"The transcriptional landscape of the mammalian genome." Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y. Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: C57BL/6J. Tissue: Gall bladder.
[3]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Brain.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	U40189 Genomic DNA. Translation: AAC52442.1. AK144461 mRNA. Translation: BAE25901.1. BC132395 mRNA. Translation: AAI32396.1. BC145981 mRNA. Translation: AAI45982.1.
IPI	IPI00314108.
PIR	S63685.
RefSeq	NP_032945.3. NM_008919.4.
UniGene	Mm.57059.
3D structure databases
ProteinModelPortal	Q61041.
SMR	Q61041. Positions 44-330.
ModBase	Search...
Protein-protein interaction databases
STRING	10090.ENSMUSP00000056576.
Protein family/group databases
GPCRDB	Search...
PTM databases
PhosphoSite	Q61041.
Proteomic databases
PRIDE	Q61041.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSMUST00000052164; ENSMUSP00000056576; ENSMUSG00000048337.
GeneID	19065.
KEGG	mmu:19065.
Organism-specific databases
CTD	5540.
MGI	MGI:105374. Ppyr1.
Phylogenomic databases
eggNOG	NOG261951.
GeneTree	ENSGT00660000095375.
HOGENOM	HOG000050229.
HOVERGEN	HBG105676.
InParanoid	Q3UN46.
KO	K04204.
OMA	FARTANL.
OrthoDB	EOG4STS4V.
Gene expression databases
Bgee	Q61041.
CleanEx	MM_PPYR1.
Genevestigator	Q61041.
GermOnline	ENSMUSG00000048337. Mus musculus.
Family and domain databases
InterPro	IPR000276. GPCR_Rhodpsn. IPR017452. GPCR_Rhodpsn_7TM. IPR001933. NPY4_rcpt. IPR000611. NPY_rcpt. [Graphical view]
Pfam	PF00001. 7tm_1. 1 hit. [Graphical view]
PRINTS	PR00237. GPCRRHODOPSN. PR01015. NRPEPTIDEY4R. PR01012. NRPEPTIDEYR.
PROSITE	PS00237. G_PROTEIN_RECEP_F1_1. 1 hit. PS50262. G_PROTEIN_RECEP_F1_2. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	295578.
SOURCE	Search...

Entry information

Entry name

NPY4R_MOUSE

Accession

Primary (citable) accession number: Q61041
Secondary accession number(s): Q3UN46

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1997
Last sequence update:	July 27, 2011
Last modified:	May 1, 2013
This is version 95 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program