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Q61041

- NPY4R_MOUSE

UniProt

Q61041 - NPY4R_MOUSE

Protein

Neuropeptide Y receptor type 4

Gene

Npy4r

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 108 (01 Oct 2014)
      Sequence version 2 (27 Jul 2011)
      Previous versions | rss
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    Functioni

    Receptor for neuropeptide Y and peptide YY. The rank order of affinity of this receptor for pancreatic polypeptides is PP >> PYY >= NPY.

    GO - Molecular functioni

    1. pancreatic polypeptide receptor activity Source: MGI
    2. peptide binding Source: Ensembl
    3. peptide YY receptor activity Source: MGI

    GO - Biological processi

    1. neuropeptide signaling pathway Source: GOC

    Keywords - Molecular functioni

    G-protein coupled receptor, Receptor, Transducer

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Neuropeptide Y receptor type 4
    Short name:
    NPY4-R
    Alternative name(s):
    NPYR-D
    Pancreatic polypeptide receptor 1
    Short name:
    PP1
    Gene namesi
    Name:Npy4r
    Synonyms:Ppyr1
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 14

    Organism-specific databases

    MGIiMGI:105374. Npy4r.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. plasma membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cell membrane, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 375375Neuropeptide Y receptor type 4PRO_0000069936Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi2 – 21N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi19 – 191N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi29 – 291N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi114 ↔ 201PROSITE-ProRule annotation
    Glycosylationi187 – 1871N-linked (GlcNAc...)Sequence Analysis
    Lipidationi340 – 3401S-palmitoyl cysteineSequence Analysis

    Keywords - PTMi

    Disulfide bond, Glycoprotein, Lipoprotein, Palmitate

    Proteomic databases

    PRIDEiQ61041.

    PTM databases

    PhosphoSiteiQ61041.

    Expressioni

    Tissue specificityi

    Heart, detected in small intestine.

    Gene expression databases

    BgeeiQ61041.
    CleanExiMM_PPYR1.
    GenevestigatoriQ61041.

    Interactioni

    Protein-protein interaction databases

    STRINGi10090.ENSMUSP00000056576.

    Structurei

    3D structure databases

    ProteinModelPortaliQ61041.
    SMRiQ61041. Positions 16-347.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 3939ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini61 – 7818CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini100 – 11617ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini138 – 15518CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini177 – 21135ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini233 – 26634CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini288 – 30114ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini323 – 37553CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei40 – 6021Helical; Name=1Sequence AnalysisAdd
    BLAST
    Transmembranei79 – 9921Helical; Name=2Sequence AnalysisAdd
    BLAST
    Transmembranei117 – 13721Helical; Name=3Sequence AnalysisAdd
    BLAST
    Transmembranei156 – 17621Helical; Name=4Sequence AnalysisAdd
    BLAST
    Transmembranei212 – 23221Helical; Name=5Sequence AnalysisAdd
    BLAST
    Transmembranei267 – 28721Helical; Name=6Sequence AnalysisAdd
    BLAST
    Transmembranei302 – 32221Helical; Name=7Sequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG261951.
    GeneTreeiENSGT00660000095375.
    HOGENOMiHOG000050229.
    HOVERGENiHBG105676.
    InParanoidiQ3UN46.
    KOiK04204.
    OMAiFARTANL.
    OrthoDBiEOG773XGC.
    TreeFamiTF315303.

    Family and domain databases

    Gene3Di1.20.1070.10. 1 hit.
    InterProiIPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    IPR001933. NPY4_rcpt.
    IPR000611. NPY_rcpt.
    [Graphical view]
    PfamiPF00001. 7tm_1. 1 hit.
    [Graphical view]
    PRINTSiPR00237. GPCRRHODOPSN.
    PR01015. NRPEPTIDEY4R.
    PR01012. NRPEPTIDEYR.
    PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
    PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q61041-1 [UniParc]FASTAAdd to Basket

    « Hide

    MNTSHFLAPL FPGSLQGKNG TNPLDSPYNF SDGCQDSAEL LAFIITTYSI    50
    ETILGVLGNL CLIFVTTRQK EKSNVTNLLI ANLAFSDFLM CLICQPLTVT 100
    YTIMDYWIFG EVLCKMLTFI QCMSVTVSIL SLVLVALERH QLIINPTGWK 150
    PSIFQAYLGI VVIWFVSCFL SLPFLANSTL NDLFHYNHSK VVEFLEDKVV 200
    CFVSWSSDHH RLIYTTFLLL FQYCIPLAFI LVCYIRIYQR LQRQKHVFHA 250
    HACSSRAGQM KRINSMLMTM VTAFAVLWLP LHVFNTLEDW YQEAIPACHG 300
    NLIFLMCHLL AMASTCVNPF IYGFLNINFK KDIKALVLTC HCRSPRGESE 350
    HLPLSTVHTD LSKGSMRMGS KSNFI 375
    Length:375
    Mass (Da):42,648
    Last modified:July 27, 2011 - v2
    Checksum:i6E04552C0E7F656E
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti166 – 1661V → I in AAC52442. (PubMed:8641440)Curated
    Sequence conflicti346 – 3461R → Q in AAC52442. (PubMed:8641440)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U40189 Genomic DNA. Translation: AAC52442.1.
    AK144461 mRNA. Translation: BAE25901.1.
    BC132395 mRNA. Translation: AAI32396.1.
    BC145981 mRNA. Translation: AAI45982.1.
    CCDSiCCDS26933.1.
    PIRiS63685.
    RefSeqiNP_032945.3. NM_008919.4.
    UniGeneiMm.57059.

    Genome annotation databases

    EnsembliENSMUST00000052164; ENSMUSP00000056576; ENSMUSG00000048337.
    GeneIDi19065.
    KEGGimmu:19065.
    UCSCiuc007tak.2. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U40189 Genomic DNA. Translation: AAC52442.1 .
    AK144461 mRNA. Translation: BAE25901.1 .
    BC132395 mRNA. Translation: AAI32396.1 .
    BC145981 mRNA. Translation: AAI45982.1 .
    CCDSi CCDS26933.1.
    PIRi S63685.
    RefSeqi NP_032945.3. NM_008919.4.
    UniGenei Mm.57059.

    3D structure databases

    ProteinModelPortali Q61041.
    SMRi Q61041. Positions 16-347.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 10090.ENSMUSP00000056576.

    Chemistry

    GuidetoPHARMACOLOGYi 307.

    Protein family/group databases

    GPCRDBi Search...

    PTM databases

    PhosphoSitei Q61041.

    Proteomic databases

    PRIDEi Q61041.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000052164 ; ENSMUSP00000056576 ; ENSMUSG00000048337 .
    GeneIDi 19065.
    KEGGi mmu:19065.
    UCSCi uc007tak.2. mouse.

    Organism-specific databases

    CTDi 5540.
    MGIi MGI:105374. Npy4r.

    Phylogenomic databases

    eggNOGi NOG261951.
    GeneTreei ENSGT00660000095375.
    HOGENOMi HOG000050229.
    HOVERGENi HBG105676.
    InParanoidi Q3UN46.
    KOi K04204.
    OMAi FARTANL.
    OrthoDBi EOG773XGC.
    TreeFami TF315303.

    Miscellaneous databases

    NextBioi 295578.
    PROi Q61041.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q61041.
    CleanExi MM_PPYR1.
    Genevestigatori Q61041.

    Family and domain databases

    Gene3Di 1.20.1070.10. 1 hit.
    InterProi IPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    IPR001933. NPY4_rcpt.
    IPR000611. NPY_rcpt.
    [Graphical view ]
    Pfami PF00001. 7tm_1. 1 hit.
    [Graphical view ]
    PRINTSi PR00237. GPCRRHODOPSN.
    PR01015. NRPEPTIDEY4R.
    PR01012. NRPEPTIDEYR.
    PROSITEi PS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
    PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Cloning and characterization of a novel receptor to pancreatic polypeptide, a member of the neuropeptide Y receptor family."
      Gregor P., Millham M.L., Feng Y., Decarr L.B., McCaleb M.L., Cornfield L.J.
      FEBS Lett. 381:58-62(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: 129/Sv.
    2. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6J.
      Tissue: Gall bladder.
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Brain.

    Entry informationi

    Entry nameiNPY4R_MOUSE
    AccessioniPrimary (citable) accession number: Q61041
    Secondary accession number(s): Q3UN46
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1997
    Last sequence update: July 27, 2011
    Last modified: October 1, 2014
    This is version 108 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. 7-transmembrane G-linked receptors
      List of 7-transmembrane G-linked receptor entries
    2. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3