Reviewed, UniProtKB/Swiss-Prot Q61041 (NPY4R_MOUSE)

Names and origin

Protein names

Recommended name:
    Neuropeptide Y receptor type 4
      Short name=NPY4-R
Alternative name(s):
    NPYR-D
    Pancreatic polypeptide receptor 1
      Short name=PP1

Gene names

Name:	Ppyr1
Synonyms:	Npy4r

Organism

Mus musculus (Mouse)

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus

Protein attributes

Sequence length	375 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Function	Receptor for neuropeptide Y and peptide YY. The rank order of affinity of this receptor for pancreatic polypeptides is PP >> PYY >= NPY.
Subcellular location	Cell membrane; Multi-pass membrane protein.
Tissue specificity	Heart, detected in small intestine.
Sequence similarities	Belongs to the G-protein coupled receptor 1 family.

Ontologies

Keywords
Cellular component	Cell membrane Membrane
Domain	Transmembrane
Molecular function	G-protein coupled receptor Receptor Transducer
PTM	Disulfide bond Glycoprotein Lipoprotein Palmitate Phosphoprotein
Gene Ontology (GO)
Biological process	G-protein coupled receptor protein signaling pathway Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW plasma membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	pancreatic polypeptide receptor activity Ref.1 Inferred from direct assay. Source: MGI peptide YY receptor activity Inferred from direct assay. Source: MGI
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 375	375	Neuropeptide Y receptor type 4		PRO_0000069936
Regions
	Topological domain	1 – 39	39	Extracellular Potential
	Transmembrane	40 – 60	21	1 Potential
	Topological domain	61 – 78	18	Cytoplasmic Potential
	Transmembrane	79 – 99	21	2 Potential
	Topological domain	100 – 116	17	Extracellular Potential
	Transmembrane	117 – 137	21	3 Potential
	Topological domain	138 – 155	18	Cytoplasmic Potential
	Transmembrane	156 – 176	21	4 Potential
	Topological domain	177 – 211	35	Extracellular Potential
	Transmembrane	212 – 232	21	5 Potential
	Topological domain	233 – 266	34	Cytoplasmic Potential
	Transmembrane	267 – 287	21	6 Potential
	Topological domain	288 – 301	14	Extracellular Potential
	Transmembrane	302 – 322	21	7 Potential
	Topological domain	323 – 375	53	Cytoplasmic Potential
Amino acid modifications
	Lipidation	340	1	S-palmitoyl cysteine Potential
	Glycosylation	2	1	N-linked (GlcNAc...) Potential
	Glycosylation	19	1	N-linked (GlcNAc...) Potential
	Glycosylation	29	1	N-linked (GlcNAc...) Potential
	Glycosylation	187	1	N-linked (GlcNAc...) Potential
	Disulfide bond	114 ↔ 201		By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q61041-1 [UniParc]. Last modified November 1, 1997. Version 1. Checksum: DFFD31775DBA310E	FASTA	375	42,634
	10 20 30 40 50 60 MNTSHFLAPL FPGSLQGKNG TNPLDSPYNF SDGCQDSAEL LAFIITTYSI ETILGVLGNL 70 80 90 100 110 120 CLIFVTTRQK EKSNVTNLLI ANLAFSDFLM CLICQPLTVT YTIMDYWIFG EVLCKMLTFI 130 140 150 160 170 180 QCMSVTVSIL SLVLVALERH QLIINPTGWK PSIFQAYLGI VVIWFISCFL SLPFLANSTL 190 200 210 220 230 240 NDLFHYNHSK VVEFLEDKVV CFVSWSSDHH RLIYTTFLLL FQYCIPLAFI LVCYIRIYQR 250 260 270 280 290 300 LQRQKHVFHA HACSSRAGQM KRINSMLMTM VTAFAVLWLP LHVFNTLEDW YQEAIPACHG 310 320 330 340 350 360 NLIFLMCHLL AMASTCVNPF IYGFLNINFK KDIKALVLTC HCRSPQGESE HLPLSTVHTD 370 LSKGSMRMGS KSNFI

References

[1]	"Cloning and characterization of a novel receptor to pancreatic polypeptide, a member of the neuropeptide Y receptor family." Gregor P., Millham M.L., Feng Y., Decarr L.B., McCaleb M.L., Cornfield L.J. FEBS Lett. 381:58-62(1996) [PubMed: 8641440] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: 129/Sv.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBLGenBankDDBJ	U40189 Genomic DNA. Translation: AAC52442.1.
IPI	IPI00314108.
PIR	S63685.
UniGene	Mm.57059
3D structure databases
ModBase	Search...
Protein family/group databases
GPCRDB	Search...
PTM databases
PhosphoSite	Q61041.
Genome annotation databases
Ensembl	ENSMUSG00000048337. Mus musculus. [Contig view]
Organism-specific databases
MGI	MGI:105374. Ppyr1.
Phylogenomic databases
HOGENOM	Q61041.
HOVERGEN	Q61041.
Gene expression databases
ArrayExpress	Q61041.
Bgee	Q61041.
CleanEx	MM_PPYR1.
GermOnline	ENSMUSG00000048337. Mus musculus.
Family and domain databases
InterPro	IPR000276. 7TM_GPCR_Rhodpsn. IPR017452. GPCR_Rhodpsn_supfam. IPR001933. NPY4_rcpt. IPR000611. NPY_rcpt. [Graphical view]
Pfam	PF00001. 7tm_1. 1 hit. [Graphical view]
PRINTS	PR00237. GPCRRHODOPSN. PR01015. NRPEPTIDEY4R. PR01012. NRPEPTIDEYR.
PROSITE	PS00237. G_PROTEIN_RECEP_F1_1. 1 hit. PS50262. G_PROTEIN_RECEP_F1_2. 1 hit. [Graphical view]
ProtoNet	Search...
Other Resources
SOURCE	Search...

Entry information

Entry name

NPY4R_MOUSE

Accession

Primary (citable) accession number: Q61041

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1997
Last sequence update:	November 1, 1997
Last modified:	June 16, 2009
This is version 64 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)