Reviewed,
UniProtKB/Swiss-Prot Q61041 (NPY4R_MOUSE)
Last modified
June 16, 2009.
Version 64.
History...
Clusters with 100%,
90%,
50% identity |
Documents (3) |
Third-party data |
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Names and origin
| Protein names | Recommended name: Neuropeptide Y receptor type 4 Short name=NPY4-R Alternative name(s): NPYR-D Pancreatic polypeptide receptor 1 Short name=PP1 | ||||
| Gene names |
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| Organism | Mus musculus (Mouse) | ||||
| Taxonomic identifier | 10090 [NCBI] | ||||
| Taxonomic lineage | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus |
Protein attributes
| Sequence length | 375 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is not processed. |
| Protein existence | Evidence at transcript level. |
General annotation (Comments)
| Function | Receptor for neuropeptide Y and peptide YY. The rank order of affinity of this receptor for pancreatic polypeptides is PP >> PYY >= NPY. |
| Subcellular location | |
| Tissue specificity | Heart, detected in small intestine. |
| Sequence similarities | Belongs to the G-protein coupled receptor 1 family. |
Ontologies
| Keywords | |
|---|---|
| Cellular component | Cell membrane Membrane |
| Domain | Transmembrane |
| Molecular function | G-protein coupled receptor Receptor Transducer |
| PTM | Disulfide bond Glycoprotein Lipoprotein Palmitate Phosphoprotein |
| Gene Ontology (GO) | |
| Biological process | G-protein coupled receptor protein signaling pathway Inferred from electronic annotation. Source: UniProtKB-KW |
| Cellular component | integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW plasma membraneInferred from electronic annotation. Source: UniProtKB-SubCell |
| Molecular function | pancreatic polypeptide receptor activity Ref.1 Inferred from direct assay. Source: MGI peptide YY receptor activityInferred from direct assay. Source: MGI |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||||
Molecule processing | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 375 | 375 | Neuropeptide Y receptor type 4 | PRO_0000069936 | |||||||
Regions | |||||||||||
| Topological domain | 1 – 39 | 39 | Extracellular Potential | ||||||||
| Transmembrane | 40 – 60 | 21 | 1 Potential | ||||||||
| Topological domain | 61 – 78 | 18 | Cytoplasmic Potential | ||||||||
| Transmembrane | 79 – 99 | 21 | 2 Potential | ||||||||
| Topological domain | 100 – 116 | 17 | Extracellular Potential | ||||||||
| Transmembrane | 117 – 137 | 21 | 3 Potential | ||||||||
| Topological domain | 138 – 155 | 18 | Cytoplasmic Potential | ||||||||
| Transmembrane | 156 – 176 | 21 | 4 Potential | ||||||||
| Topological domain | 177 – 211 | 35 | Extracellular Potential | ||||||||
| Transmembrane | 212 – 232 | 21 | 5 Potential | ||||||||
| Topological domain | 233 – 266 | 34 | Cytoplasmic Potential | ||||||||
| Transmembrane | 267 – 287 | 21 | 6 Potential | ||||||||
| Topological domain | 288 – 301 | 14 | Extracellular Potential | ||||||||
| Transmembrane | 302 – 322 | 21 | 7 Potential | ||||||||
| Topological domain | 323 – 375 | 53 | Cytoplasmic Potential | ||||||||
Amino acid modifications | |||||||||||
| Lipidation | 340 | 1 | S-palmitoyl cysteine Potential | ||||||||
| Glycosylation | 2 | 1 | N-linked (GlcNAc...) Potential | ||||||||
| Glycosylation | 19 | 1 | N-linked (GlcNAc...) Potential | ||||||||
| Glycosylation | 29 | 1 | N-linked (GlcNAc...) Potential | ||||||||
| Glycosylation | 187 | 1 | N-linked (GlcNAc...) Potential | ||||||||
| Disulfide bond | 114 ↔ 201 | By similarity | |||||||||
Sequences
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References
| [1] | "Cloning and characterization of a novel receptor to pancreatic polypeptide, a member of the neuropeptide Y receptor family." Gregor P., Millham M.L., Feng Y., Decarr L.B., McCaleb M.L., Cornfield L.J. FEBS Lett. 381:58-62(1996) [PubMed: 8641440] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: 129/Sv. |
| + | Additional computationally mapped references. |
Cross-references
Sequence databases | |
|---|---|
| U40189 Genomic DNA. Translation: AAC52442.1. | |
| IPI | IPI00314108. |
| PIR | S63685. |
| UniGene | Mm.57059 |
3D structure databases | |
| ModBase | Search... |
Protein family/group databases | |
| GPCRDB | Search... |
PTM databases | |
| PhosphoSite | Q61041. |
Genome annotation databases | |
| Ensembl | ENSMUSG00000048337. Mus musculus. [Contig view] |
Organism-specific databases | |
| MGI | MGI:105374. Ppyr1. |
Phylogenomic databases | |
| HOGENOM | Q61041. |
| HOVERGEN | Q61041. |
Gene expression databases | |
| ArrayExpress | Q61041. |
| Bgee | Q61041. |
| CleanEx | MM_PPYR1. |
| GermOnline | ENSMUSG00000048337. Mus musculus. |
Family and domain databases | |
| InterPro | IPR000276. 7TM_GPCR_Rhodpsn. IPR017452. GPCR_Rhodpsn_supfam. IPR001933. NPY4_rcpt. IPR000611. NPY_rcpt. [Graphical view] |
| Pfam | PF00001. 7tm_1. 1 hit. [Graphical view] |
| PRINTS | PR00237. GPCRRHODOPSN. PR01015. NRPEPTIDEY4R. PR01012. NRPEPTIDEYR. |
| PROSITE | PS00237. G_PROTEIN_RECEP_F1_1. 1 hit. PS50262. G_PROTEIN_RECEP_F1_2. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Other Resources | |
| SOURCE | Search... |
Entry information
| Entry name | NPY4R_MOUSE | ||||||||
| Accession | Primary (citable) accession number: Q61041 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | HPI (Human Proteome Initiative) | ||||||||
Relevant documents
| 7-transmembrane G-linked receptors List of 7-transmembrane G-linked receptor entries |
| MGD cross-references Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot |
| SIMILARITY comments Index of protein domains and families |

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