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Protein

Neuropeptide Y receptor type 4

Gene

Npy4r

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Receptor for neuropeptide Y and peptide YY. The rank order of affinity of this receptor for pancreatic polypeptides is PP >> PYY >= NPY.

GO - Molecular functioni

  • pancreatic polypeptide receptor activity Source: MGI
  • peptide binding Source: Ensembl
  • peptide YY receptor activity Source: MGI

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

ReactomeiR-MMU-375276. Peptide ligand-binding receptors.
R-MMU-418594. G alpha (i) signalling events.

Names & Taxonomyi

Protein namesi
Recommended name:
Neuropeptide Y receptor type 4
Short name:
NPY4-R
Alternative name(s):
NPYR-D
Pancreatic polypeptide receptor 1
Short name:
PP1
Gene namesi
Name:Npy4r
Synonyms:Ppyr1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 14

Organism-specific databases

MGIiMGI:105374. Npy4r.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 39ExtracellularSequence analysisAdd BLAST39
Transmembranei40 – 60Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini61 – 78CytoplasmicSequence analysisAdd BLAST18
Transmembranei79 – 99Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini100 – 116ExtracellularSequence analysisAdd BLAST17
Transmembranei117 – 137Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini138 – 155CytoplasmicSequence analysisAdd BLAST18
Transmembranei156 – 176Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini177 – 211ExtracellularSequence analysisAdd BLAST35
Transmembranei212 – 232Helical; Name=5Sequence analysisAdd BLAST21
Topological domaini233 – 266CytoplasmicSequence analysisAdd BLAST34
Transmembranei267 – 287Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini288 – 301ExtracellularSequence analysisAdd BLAST14
Transmembranei302 – 322Helical; Name=7Sequence analysisAdd BLAST21
Topological domaini323 – 375CytoplasmicSequence analysisAdd BLAST53

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Chemistry databases

GuidetoPHARMACOLOGYi307.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000699361 – 375Neuropeptide Y receptor type 4Add BLAST375

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi2N-linked (GlcNAc...)Sequence analysis1
Glycosylationi19N-linked (GlcNAc...)Sequence analysis1
Glycosylationi29N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi114 ↔ 201PROSITE-ProRule annotation
Glycosylationi187N-linked (GlcNAc...)Sequence analysis1
Lipidationi340S-palmitoyl cysteineSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein, Lipoprotein, Palmitate

Proteomic databases

PaxDbiQ61041.
PRIDEiQ61041.

PTM databases

PhosphoSitePlusiQ61041.

Expressioni

Tissue specificityi

Heart, detected in small intestine.

Gene expression databases

BgeeiENSMUSG00000048337.
CleanExiMM_PPYR1.
GenevisibleiQ61041. MM.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000056576.

Structurei

3D structure databases

ProteinModelPortaliQ61041.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3656. Eukaryota.
ENOG410XRW9. LUCA.
GeneTreeiENSGT00760000118781.
HOGENOMiHOG000050229.
HOVERGENiHBG105676.
InParanoidiQ61041.
KOiK04206.
OMAiTAVYTIM.
OrthoDBiEOG091G0HOS.
TreeFamiTF315303.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR001933. NPY4_rcpt.
IPR000611. NPY_rcpt.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR01015. NRPEPTIDEY4R.
PR01012. NRPEPTIDEYR.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q61041-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNTSHFLAPL FPGSLQGKNG TNPLDSPYNF SDGCQDSAEL LAFIITTYSI
60 70 80 90 100
ETILGVLGNL CLIFVTTRQK EKSNVTNLLI ANLAFSDFLM CLICQPLTVT
110 120 130 140 150
YTIMDYWIFG EVLCKMLTFI QCMSVTVSIL SLVLVALERH QLIINPTGWK
160 170 180 190 200
PSIFQAYLGI VVIWFVSCFL SLPFLANSTL NDLFHYNHSK VVEFLEDKVV
210 220 230 240 250
CFVSWSSDHH RLIYTTFLLL FQYCIPLAFI LVCYIRIYQR LQRQKHVFHA
260 270 280 290 300
HACSSRAGQM KRINSMLMTM VTAFAVLWLP LHVFNTLEDW YQEAIPACHG
310 320 330 340 350
NLIFLMCHLL AMASTCVNPF IYGFLNINFK KDIKALVLTC HCRSPRGESE
360 370
HLPLSTVHTD LSKGSMRMGS KSNFI
Length:375
Mass (Da):42,648
Last modified:July 27, 2011 - v2
Checksum:i6E04552C0E7F656E
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti166V → I in AAC52442 (PubMed:8641440).Curated1
Sequence conflicti346R → Q in AAC52442 (PubMed:8641440).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U40189 Genomic DNA. Translation: AAC52442.1.
AK144461 mRNA. Translation: BAE25901.1.
BC132395 mRNA. Translation: AAI32396.1.
BC145981 mRNA. Translation: AAI45982.1.
CCDSiCCDS26933.1.
PIRiS63685.
RefSeqiNP_032945.3. NM_008919.4.
UniGeneiMm.57059.

Genome annotation databases

EnsembliENSMUST00000052164; ENSMUSP00000056576; ENSMUSG00000048337.
GeneIDi19065.
KEGGimmu:19065.
UCSCiuc007tak.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U40189 Genomic DNA. Translation: AAC52442.1.
AK144461 mRNA. Translation: BAE25901.1.
BC132395 mRNA. Translation: AAI32396.1.
BC145981 mRNA. Translation: AAI45982.1.
CCDSiCCDS26933.1.
PIRiS63685.
RefSeqiNP_032945.3. NM_008919.4.
UniGeneiMm.57059.

3D structure databases

ProteinModelPortaliQ61041.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000056576.

Chemistry databases

GuidetoPHARMACOLOGYi307.

Protein family/group databases

GPCRDBiSearch...

PTM databases

PhosphoSitePlusiQ61041.

Proteomic databases

PaxDbiQ61041.
PRIDEiQ61041.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000052164; ENSMUSP00000056576; ENSMUSG00000048337.
GeneIDi19065.
KEGGimmu:19065.
UCSCiuc007tak.2. mouse.

Organism-specific databases

CTDi5540.
MGIiMGI:105374. Npy4r.

Phylogenomic databases

eggNOGiKOG3656. Eukaryota.
ENOG410XRW9. LUCA.
GeneTreeiENSGT00760000118781.
HOGENOMiHOG000050229.
HOVERGENiHBG105676.
InParanoidiQ61041.
KOiK04206.
OMAiTAVYTIM.
OrthoDBiEOG091G0HOS.
TreeFamiTF315303.

Enzyme and pathway databases

ReactomeiR-MMU-375276. Peptide ligand-binding receptors.
R-MMU-418594. G alpha (i) signalling events.

Miscellaneous databases

PROiQ61041.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000048337.
CleanExiMM_PPYR1.
GenevisibleiQ61041. MM.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR001933. NPY4_rcpt.
IPR000611. NPY_rcpt.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR01015. NRPEPTIDEY4R.
PR01012. NRPEPTIDEYR.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiNPY4R_MOUSE
AccessioniPrimary (citable) accession number: Q61041
Secondary accession number(s): Q3UN46
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: July 27, 2011
Last modified: November 2, 2016
This is version 122 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.