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Q61041 (NPY4R_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 105. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Neuropeptide Y receptor type 4

Short name=NPY4-R
Alternative name(s):
NPYR-D
Pancreatic polypeptide receptor 1
Short name=PP1
Gene names
Name:Npy4r
Synonyms:Ppyr1
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length375 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Receptor for neuropeptide Y and peptide YY. The rank order of affinity of this receptor for pancreatic polypeptides is PP >> PYY >= NPY.

Subcellular location

Cell membrane; Multi-pass membrane protein.

Tissue specificity

Heart, detected in small intestine.

Sequence similarities

Belongs to the G-protein coupled receptor 1 family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 375375Neuropeptide Y receptor type 4
PRO_0000069936

Regions

Topological domain1 – 3939Extracellular Potential
Transmembrane40 – 6021Helical; Name=1; Potential
Topological domain61 – 7818Cytoplasmic Potential
Transmembrane79 – 9921Helical; Name=2; Potential
Topological domain100 – 11617Extracellular Potential
Transmembrane117 – 13721Helical; Name=3; Potential
Topological domain138 – 15518Cytoplasmic Potential
Transmembrane156 – 17621Helical; Name=4; Potential
Topological domain177 – 21135Extracellular Potential
Transmembrane212 – 23221Helical; Name=5; Potential
Topological domain233 – 26634Cytoplasmic Potential
Transmembrane267 – 28721Helical; Name=6; Potential
Topological domain288 – 30114Extracellular Potential
Transmembrane302 – 32221Helical; Name=7; Potential
Topological domain323 – 37553Cytoplasmic Potential

Amino acid modifications

Lipidation3401S-palmitoyl cysteine Potential
Glycosylation21N-linked (GlcNAc...) Potential
Glycosylation191N-linked (GlcNAc...) Potential
Glycosylation291N-linked (GlcNAc...) Potential
Glycosylation1871N-linked (GlcNAc...) Potential
Disulfide bond114 ↔ 201 By similarity

Experimental info

Sequence conflict1661V → I in AAC52442. Ref.1
Sequence conflict3461R → Q in AAC52442. Ref.1

Sequences

Sequence LengthMass (Da)Tools
Q61041 [UniParc].

Last modified July 27, 2011. Version 2.
Checksum: 6E04552C0E7F656E

FASTA37542,648
        10         20         30         40         50         60 
MNTSHFLAPL FPGSLQGKNG TNPLDSPYNF SDGCQDSAEL LAFIITTYSI ETILGVLGNL 

        70         80         90        100        110        120 
CLIFVTTRQK EKSNVTNLLI ANLAFSDFLM CLICQPLTVT YTIMDYWIFG EVLCKMLTFI 

       130        140        150        160        170        180 
QCMSVTVSIL SLVLVALERH QLIINPTGWK PSIFQAYLGI VVIWFVSCFL SLPFLANSTL 

       190        200        210        220        230        240 
NDLFHYNHSK VVEFLEDKVV CFVSWSSDHH RLIYTTFLLL FQYCIPLAFI LVCYIRIYQR 

       250        260        270        280        290        300 
LQRQKHVFHA HACSSRAGQM KRINSMLMTM VTAFAVLWLP LHVFNTLEDW YQEAIPACHG 

       310        320        330        340        350        360 
NLIFLMCHLL AMASTCVNPF IYGFLNINFK KDIKALVLTC HCRSPRGESE HLPLSTVHTD 

       370 
LSKGSMRMGS KSNFI 

« Hide

References

« Hide 'large scale' references
[1]"Cloning and characterization of a novel receptor to pancreatic polypeptide, a member of the neuropeptide Y receptor family."
Gregor P., Millham M.L., Feng Y., Decarr L.B., McCaleb M.L., Cornfield L.J.
FEBS Lett. 381:58-62(1996) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: 129/Sv.
[2]"The transcriptional landscape of the mammalian genome."
Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. expand/collapse author list , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: C57BL/6J.
Tissue: Gall bladder.
[3]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Brain.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
U40189 Genomic DNA. Translation: AAC52442.1.
AK144461 mRNA. Translation: BAE25901.1.
BC132395 mRNA. Translation: AAI32396.1.
BC145981 mRNA. Translation: AAI45982.1.
PIRS63685.
RefSeqNP_032945.3. NM_008919.4.
UniGeneMm.57059.

3D structure databases

ProteinModelPortalQ61041.
SMRQ61041. Positions 44-330.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING10090.ENSMUSP00000056576.

Chemistry

GuidetoPHARMACOLOGY307.

Protein family/group databases

GPCRDBSearch...

PTM databases

PhosphoSiteQ61041.

Proteomic databases

PRIDEQ61041.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000052164; ENSMUSP00000056576; ENSMUSG00000048337.
GeneID19065.
KEGGmmu:19065.
UCSCuc007tak.2. mouse.

Organism-specific databases

CTD5540.
MGIMGI:105374. Npy4r.

Phylogenomic databases

eggNOGNOG261951.
GeneTreeENSGT00660000095375.
HOGENOMHOG000050229.
HOVERGENHBG105676.
InParanoidQ3UN46.
KOK04204.
OMAFARTANL.
OrthoDBEOG773XGC.
TreeFamTF315303.

Gene expression databases

BgeeQ61041.
CleanExMM_PPYR1.
GenevestigatorQ61041.

Family and domain databases

Gene3D1.20.1070.10. 1 hit.
InterProIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR001933. NPY4_rcpt.
IPR000611. NPY_rcpt.
[Graphical view]
PfamPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSPR00237. GPCRRHODOPSN.
PR01015. NRPEPTIDEY4R.
PR01012. NRPEPTIDEYR.
PROSITEPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio295578.
PROQ61041.
SOURCESearch...

Entry information

Entry nameNPY4R_MOUSE
AccessionPrimary (citable) accession number: Q61041
Secondary accession number(s): Q3UN46
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: July 27, 2011
Last modified: April 16, 2014
This is version 105 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

7-transmembrane G-linked receptors

List of 7-transmembrane G-linked receptor entries